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The reported advantage of new dual-cured adhesive agents is that they do not require light curing, resulting in a reduced film thickness and improved seating of bonded all-ceramic restorations. The purpose of this study was to determine the effect of dual-cured adhesives on the bond strength of dual-cured resin cement to dentin under different polymerization conditions: with or without light curing of the dual-cured adhesive as well as with or without light curing of the dual-cured resin cement through a lithium disilicate ceramic material. Human molars were sectioned to remove the coronal tooth structure and randomly divided into 3 adhesive groups: Clearfil SE Bond 2, ExciTE F DSC, and Universal Primer. The adhesive agents were applied to the dentin surface with or without light activation. A dual-cured resin cement was applied, and discs of lithium disilicate were cemented to the dentin surface. Half of the discs were light cured from the top surface, and the other half were allowed to self-cure. Shear bond strength was tested after storage in distilled water for 24 hours. The effect of light curing of the adhesive or cement on the shear bond strength of the lithium disilicate discs to dentin was product dependent. Clearfil SE Bond 2 performed significantly better with light curing of both the adhesive and cement. Less significant effects of the various light-curing and self-curing combinations were observed with ExciTE F DSC or Universal Primer. When neither the adhesive nor the cement was light cured, all 3 adhesives performed poorly and had a significant loss in bond strength., Competing Interests: The authors report no conflicts of interest pertaining to any of the products or companies discussed in this article. The views expressed in this article are those of the authors and do not reflect the official policy of the US Air Force, the Department of Defense, Uniformed Services University of the Health Sciences, or the US government.