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311 results on '"Nephew, Lauren"'

1. Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis

Author

Chalasani, Naga, Patidar, Kavish R., Vuppalanchi, Raj, Samala, Niha, Yoder, Lindsey, Nephew, Lauren, Shah, Vijay H., Simonetto, Douglas A., Kamath, Patrick, Vargas, Hugo E., Yang, Liu, Dasarathy, Srinivasan, Welch, Nicole, Bellar, Annette, Attaway, Amy, Dasarathy, Jaividhya, Growley, Ashley, Streem, David, Nagy, Laura E., Mitchell, Mack C., Herlong, H. Franklin, Kerr, Thomas, Cotter, Thomas, Sanyal, Arun, O'Connor, Sara, Luketic, Velimir, Asgharpour, Amon, Taylor, Stephanie, McClain, Craig J., Vatsalya, Vatsalya, Jophlin, Loretta, Cave, Matt, Jha, Suman Kumar, Marsano, Luis, Barve, Ashutosh, Frimodig, Jane, Bataller, Ramon, Ravi, Samhita, Behari, Jaideep, Shivanekar, Sharvari, Novelli, Paula, Duarte-Rojo, Andres, Jonassaint, Naudia, Szabo, Gyongyi, Curry, Jiang, Zhenghui G., Agarwal, Ushma, Hazel, Mia, Schnabl, Bernd, Gawrieh, Samer, Tu, Wanzhu, Kamath, Patrick S., Chalasani, Naga P., Tang, Qing, Radaeva, Svetlana, Barton, Bruce, and Sanyal, Arun J.

Published
2024
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14. Low socioeconomic status exacerbates unmet health‐related needs in patients with autoimmune hepatitis.

Author

Singleton, Carolyn, Carter, Allie, Baker, Brittany, Jones, Emma, Green, Kelsey, Lammert, Craig, and Nephew, Lauren D.

Subjects
AUTOIMMUNE hepatitis, SYSTEMIC lupus erythematosus, INCOME, MEDICAL personnel, LOGISTIC regression analysis
Abstract

Summary: Background and Aims: Diminished quality of life has been well characterized in patients with autoimmune hepatitis (AIH); however, the full spectrum of unmet needs is unclear. We hypothesized that there is a high burden of health‐related unmet needs in patients with AIH, and this burden differs by socioeconomic status (SES). Methods: Members of the Autoimmune Hepatitis Association were invited online and by email to complete a modified version of the Systemic Lupus Erythematosus Patient Needs Questionnaire. Demographic and clinical data were also captured. Low SES was defined as annual household income <30 k, education level below high school, or moderate–high concern for transportation, food or housing. Multivariable logistic regression assessed the association between unmet health‐related needs and SES. Results: There were 433 participants; 89.8% identified as women, 16.2% lived outside the US, and 25.6% were classified as low SES. Over 70% of respondents reported at least one moderate–high need in the health‐related unmet need domains. In multivariable logistic regression, patients in the low‐SES group reported significantly higher odds of unmet needs compared to the moderate–high‐SES group: for adequate information about side effects (OR 1.64, 95% CI 1.06–2.53, p = 0.026), opportunity to speak with others with AIH (OR 2.34, 95% CI 1.50–3.66, p < 0.001), healthcare professionals acknowledging patient emotions (OR 2.41, 95% CI 1.56–3.74, p < 0.001) and being taken seriously by medical providers (OR 2.09, 95% CI 1.34–3.28, p = 0.001). Conclusion: There is a high burden of health‐related unmet needs in all patients with AIH that is exacerbated by low SES. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Incidence, clinical characteristics, and risk factors associated with recurrent alcohol-associated hepatitis

Author

Patidar, Kavish R., primary, Guarnizo Ortiz, Maria, additional, Slaven, James E., additional, Nephew, Lauren D., additional, Vilar Gomez, Eduardo, additional, Kettler, Carla D., additional, Ghabril, Marwan S., additional, Desai, Archita P., additional, Orman, Eric S., additional, Chalasani, Naga, additional, and Gawrieh, Samer, additional

Published
2023
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26. Clinical characteristics and prognosis of hospitalized patients with moderate alcohol‐associated hepatitis

Author

Gaurnizo‐Ortiz, Maria, primary, Nephew, Lauren D., additional, Vilar‐Gomez, Eduardo, additional, Kettler, Carla D., additional, Slaven, James E., additional, Ghabril, Marwan S., additional, Desai, Archita P., additional, Orman, Eric S., additional, Chalasani, Naga, additional, Gawrieh, Samer, additional, and Patidar, Kavish R., additional

Published
2023
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29. S1424 Early vs Delayed Diagnostic Paracentesis in Hospitalized Patients With Cirrhosis and Ascites: A Systematic Review and Meta-Analysis

Author

Beran, Azizullah, primary, Mohamed, Mouhand FH., additional, Vargas, Alejandra, additional, Aboursheid, Tarek, additional, Nawras, Mohamad, additional, Jaber, Fouad, additional, Hernaez, Ruben, additional, Patidar, Kavish, additional, Nephew, Lauren, additional, Desai, Archita, additional, Orman, Eric, additional, and Ghabril, Marwan, additional

Published
2023
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31. Thirty-Day Readmissions Are Largely Not Preventable in Patients With Cirrhosis

Author

Orman, Eric S., primary, Desai, Archita P., additional, Ghabril, Marwan S., additional, Nephew, Lauren D., additional, Patidar, Kavish R., additional, Holden, John, additional, Samala, Niharika R., additional, Gawrieh, Samer, additional, Vuppalanchi, Raj, additional, Sozio, Margaret, additional, Lacerda, Marco, additional, Vilar-Gomez, Eduardo, additional, Lammert, Craig, additional, Liangpunsakul, Suthat, additional, Crabb, David, additional, Masuoka, Howard, additional, Dakhoul, Lara, additional, Pan, Minmin, additional, Gao, Sujuan, additional, and Chalasani, Naga, additional

Published
2023
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32. Parental leave, childcare policies, and workplace bias for hepatology professionals: A national survey

Author

Feld, Lauren D., primary, Sarkar, Monika, additional, Au, Jennifer S., additional, Flemming, Jennifer A., additional, Gripshover, Janet, additional, Kardashian, Ani, additional, Muir, Andrew J., additional, Nephew, Lauren, additional, Orloff, Susan L., additional, Terrault, Norah, additional, Rabinowitz, Loren, additional, Volerman, Anna, additional, Arora, Vineet, additional, Farnan, Jeanne, additional, and Villa, Erica, additional

Published
2023
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35. Thirty-Day Readmissions Are Largely Not Preventable in Patients With Cirrhosis.

Author

Orman, Eric S., Desai, Archita P., Ghabril, Marwan S., Nephew, Lauren D., Patidar, Kavish R., Holden, John, Samala, Niharika R., Gawrieh, Samer, Vuppalanchi, Raj, Sozio, Margaret, Lacerda, Marco, Vilar-Gomez, Eduardo, Lammert, Craig, Liangpunsakul, Suthat, Crabb, David, Masuoka, Howard, Dakhoul, Lara, Pan, Minmin, Gao, Sujuan, and Chalasani, Naga

Published
2024
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39. PROMIS Profile-29 is a valid instrument with distinct advantages over legacy instruments for measuring the quality of life in chronic liver disease

Author

Desai, Archita P., primary, Madathanapalli, Abhishek, additional, Tang, Qing, additional, Orman, Eric S., additional, Lammert, Craig, additional, Patidar, Kavish R., additional, Nephew, Lauren D., additional, Ghabril, Marwan, additional, Monahan, Patrick O., additional, and Chalasani, Naga, additional

Published
2023
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42. Clinical characteristics and prognosis of hospitalized patients with moderate alcohol‐associated hepatitis.

Author

Gaurnizo‐Ortiz, Maria, Nephew, Lauren D., Vilar‐Gomez, Eduardo, Kettler, Carla D., Slaven, James E., Ghabril, Marwan S., Desai, Archita P., Orman, Eric S., Chalasani, Naga, Gawrieh, Samer, and Patidar, Kavish R.

Subjects
*HOSPITAL patients, *HEPATITIS, *ACUTE kidney failure, *PROGNOSIS, MORTALITY risk factors
Abstract

Background and Aims: Little is known about the clinical characteristics and prognosis of hospitalized patients with moderate alcohol‐associated hepatitis (mAH) as compared to severe alcohol‐associated hepatitis (sAH). Therefore, we aimed to describe the clinical characteristics and risk factors associated with mortality in hospitalized mAH patients. Methods: Patients hospitalized with alcohol‐associated hepatitis (AH) from 1 January 2010 to 31 December 2020 at a large US healthcare system [11 hospitals, one liver transplant centre] were retrospectively analysed for outcomes. Primary outcome was 90‐day mortality. AH and mAH were defined according to NIAAA Alcoholic Hepatitis Consortia and Model for End‐stage Liver Disease Score ≤ 20 respectively. Multivariable Cox regression analysis was performed to identify independent risk factors associated with 90‐day mortality. Results: 1504 AH patients were hospitalized during the study period, of whom 39% (n = 590) had mAH. Compared to sAH patients, mAH patients were older (50 vs. 48 years, p < 0.001) and less likely to have underlying cirrhosis (74% vs. 83%, p < 0.001). There were no differences between the two groups for median alcohol intake g/day (mAH 140.0 vs. sAH 112.0, p = 0.071). The cumulative proportion surviving at 90 days was 88% in mAH versus 62% in sAH (p < 0.001). On multivariable analysis, older age [HR 1.03 (95% CI 1.00–1.06), p = 0.020], corticosteroid use [HR 1.80 (95% CI 1.06–3.06), p = 0.030] and acute kidney injury (AKI) [HR 2.43 (95% CI 1.33–4.47), p = 0.004] were independently associated with 90‐day mortality. Conclusions: mAH carries a 12% mortality rate at 90 days. Age, AKI and corticosteroid use were associated with an increased risk for 90‐day mortality. Avoidance of corticosteroids and strategies to reduce the risk of AKI could improve outcomes in mAH patients. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Severe hepatic encephalopathy with mechanical ventilation may inform waitlist priority in acute liver failure: A UNOS database analysis.

Author

Ma, Jiayi, Slaven, James E., Nephew, Lauren, Patidar, Kavish R., Desai, Archita P., Orman, Eric, Kubal, Chandrashekhar, Chalasani, Naga, and Ghabril, Marwan

Subjects
HEPATIC encephalopathy, LIVER failure, ARTIFICIAL respiration, DATABASES, BRAIN diseases, MULTIPLE organ failure, HEPATIC veno-occlusive disease
Abstract

Background & Aims: Patients with acute liver failure (ALF) awaiting liver transplantation (LT) may develop multiorgan failure, but organ failure does not impact waitlist prioritization. The aim of this study was to examine the impact of organ failure on waitlist mortality risk and post LT outcomes in patients with ALF. Methods: We studied adults waitlisted for ALF in the United Network for Organ Sharing (UNOS) database (2002–2019). Organ failures were defined using a previously described Chronic Liver Failure modified sequential organ failure score assessment adapted to UNOS data. Regression analyses of the primary endpoints, 30‐day waitlist mortality (Competing risk), and post‐LT mortality (Cox‐proportional hazards), were performed. Latent class analysis (LCA) was used to determine the organ failures most closely associated with 30‐day waitlist mortality. Results: About 3212 adults with ALF were waitlisted, for hepatotoxicity (41%), viral (12%) and unspecified (36%) etiologies. The median number of organ failures was three (interquartile range 1–3). Having ≥3 organ failures (vs. ≤2) was associated with a sub hazard ratio (HR) of 2.7 (95%CI 2.2–3.4)) and a HR of 1.5 (95%CI 1.1–2.5)) for waitlist and post‐LT mortality, respectively. LCA identified neurologic and respiratory failure as most impactful on 30‐day waitlist mortality. The odds ratios for both organ failures (vs. neither) were higher for mortality 4.5 (95% CI 3.4–5.9) and lower for delisting for spontaneous survival.5 (95%CI.4–.7) and LT.6 (95%CI.5–.7). Conclusion: Cumulative organ failure, especially neurologic and respiratory failure, significantly impacts waitlist and post‐LT mortality in patients with ALF and may inform risk‐prioritized allocation of organs. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Longer time to recovery from acute kidney injury is associated with major adverse kidney events in patients with cirrhosis

Author

Patidar, Kavish R., primary, Naved, Mobasshir A., additional, Kabir, Shaowli, additional, Grama, Ananth, additional, Allegretti, Andrew S., additional, Cullaro, Giuseppe, additional, Asrani, Sumeet K., additional, Worden, Astin, additional, Desai, Archita P., additional, Ghabril, Marwan S., additional, Nephew, Lauren D., additional, and Orman, Eric S., additional

Published
2023
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