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21 results on '"Nermes, Merja"'

3. The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic

Author

Gómez-Gallego, Carlos, Forsgren, Mira, Selma Royo, Marta, Nermes, Merja, Collado, María Carmen, Salminen, Seppo, Beasley, Shea, Isolauri, Erika, Gómez-Gallego, Carlos, Forsgren, Mira, Selma Royo, Marta, Nermes, Merja, Collado, María Carmen, Salminen, Seppo, Beasley, Shea, and Isolauri, Erika

Abstract

The development of the infant gut microbiota is initiated during pregnancy and continued through early life and childhood, guided by the immediate environment of the child. Our aim was to characterize the shared microbiota between dogs and children as well as to determine whether introduction to dogs of a dog-specific probiotic combination modifies the transfer process. We studied 31 children from allergic families with pet dog(s) and 18 control families without a dog. Altogether 37 dogs were randomized for a 4-week period in a double-blind design to receive canine-derived probiotic product containing a mixture of L. fermentum, L. plantarum, and L. rhamnosus, or placebo. Fecal samples from children and dogs were taken before and after the treatment. Distinctive gut microbiota composition was observed in children with dogs compared to those without a dog, characterized by higher abundance of Bacteroides and short-chain fatty acid producing bacteria such as Ruminococcus and Lachnospiraceae. Probiotic intervention in dogs had an impact on the composition of the gut microbiota in both dogs and children, characterized by a reduction in Bacteroides. We provide evidence for a direct effect of home environment and household pets on children microbiota and document that modification of dog microbiota by specific probiotics is reflected in children’s microbiota.

Published
2021

7. An Infant Formula with Partially Hydrolyzed Whey Protein Supports Adequate Growth and Is Safe and Well-Tolerated in Healthy, Term Infants: A Randomized, Double-Blind, Equivalence Trial

Author

Universitat Rovira i Virgili, Picaud, Jean-Charles; Pajek, Barbara; Arciszewska, Malgorzata; Tarczon, Izabela; Escribano, Joaquin; Porcel, Rocio; Adelt, Thomas; Hassink, Elly; Rijnierse, Anneke; Abrahamse-Berkeveld, Marieke; Korczowski, Bartosz; Mazela, Jan; Schlembach, Dietmar; Oudshoorn, Annemarie; Kalach, Nicolas; Pastor Rosado, Jose; Closa, Ricardo; Nermes, Merja; Laitinen, Kirsi;TENUTO Study Grp, Universitat Rovira i Virgili, and Picaud, Jean-Charles; Pajek, Barbara; Arciszewska, Malgorzata; Tarczon, Izabela; Escribano, Joaquin; Porcel, Rocio; Adelt, Thomas; Hassink, Elly; Rijnierse, Anneke; Abrahamse-Berkeveld, Marieke; Korczowski, Bartosz; Mazela, Jan; Schlembach, Dietmar; Oudshoorn, Annemarie; Kalach, Nicolas; Pastor Rosado, Jose; Closa, Ricardo; Nermes, Merja; Laitinen, Kirsi;TENUTO Study Grp

Abstract

The current study evaluates the safety and tolerance of a partially hydrolyzed whey protein-based infant formula (PHF) versus an in intact cow's milk protein formula (IPF). Breastfed infants were included as a reference group. In a multi-country, multicenter, randomized, double-blinded, controlled clinical trial, infants whose mothers intended to fully formula feed were randomized to PHF (n= 134) or IPF (n= 134) from <= 14 days to 17 weeks of age. The equivalence analysis of weight gain per day within margins of +/-3 g/d (primary outcome), the recorded adverse events, growth and gastro-intestinal tolerance parameters were considered for the safety evaluation. Equivalence of weight gain per day from enrolment until 17 weeks of age was demonstrated in the PHF group compared to the IPF group (difference in means -1.2 g/d; 90% CI (-2.42; 0.02)), with estimated means (SE) of 30.2 (0.5) g/d and 31.4 (0.5) g/d, respectively. No significant differences in growth outcomes, the number, severity or type of (serious) adverse events and tolerance outcomes, were observed between the two formula groups. A partially hydrolyzed whey protein-based infant formula supports adequate infant growth, with a daily weight gain equivalent to a standard intact protein-based formula; it is also safe for use and well-tolerated in healthy term infants.

Published
2020

9. Proceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects: Rome, Italy/Vatican City. 27-29 April 2017

Author

Traina, Giovanni, Valluzzi, Rocco Luigi, Fierro, Vincenzo, Riccardi, Carla, Artesani, Maria Cristina, De Vuono, Andrea, Fiocchi, Alessandro, Martelli, Alberto G, Ríos, Luis Alberto, Alcocer, Christian R, Navarrete, Elsy, Del Rio Navarro, Blanca Estela, Gonzalez, Victor, Velasco, Berenice, Perez Aviles, Herberth J, Fernandez, Roberto Jose, Pozo, F Cesar, Farhan, Abdal Jabbar, Arshad, Hasan, Hussain, Ahmed, Sharikadze, Olena, Okhotnikova, Olena, Alcover, Javier, Rodriguez, Diego, Pineda, Fernando, Dalal, Ilan, Weinbrand-Goichberg, Jenny, Benor, Shira, Rottem, Menachem, Kivity, Shmuel, Sato, Sakura, Yanagida, Noriyuki, Ebisawa, Motohiro, Umanets, Tetiana, Antipkin, Youriy, Barzylovich, Vladyslava, Lapshyn, Volodymyr, Umanets, Mykola, Yuriev, Sergey, Bekir, Suzan, Pincock, Tobias, Vieira Hernandez, Alberto, Capriles Hulett, Arnaldo, Sánchez Borges, Mario, Fabiano, Fabiola, Albarran, Carlos, Goyal, Rohit, Gupta, Shilpa, Gaurav, Garg, Luskin, Allan T, Griffin, Noelle M, Wagelie-Steffen, Amy, Trzaskoma, Benjamin L, Limb, Susan L, Busse, William W, Zeiger, Robert S, Gonzalez-Reyes, Erika, Casale, Thomas B, Chipps, Bradley E, Sugizaki, Chizuko, Goto, Fumiko, Yamaide, Akiko, Mitsunaga, Kanako, Tomiita, Minako, Hoshioka, Akira, Shimojo, Naoki, Pop, Liviu L, Ciucǎ, Ioana-Mihaela, Tǎmaş, Liviu, Lazarescu, Marilena, Pienar, Corina, Yamaide, Fumiya, Fikri, Bahrul, Sato, Hironori, Okishima, Naoko, Kobayashi, Miyabi, Takai, Mizuki, Nishigata, Kotarou, Yoda, Ryou, Oana, Yu-Ta, Kajiwara, Chifu, Shimodaira, Moe, Suzuki, Tomoka, Iizawa, Hiromi, Kamijo, Koji, Karmakar, Bijoya, Bhattacharya, Swati Gupta, Blohlávková, Simona, Kopelentová, Eliška, Víšek, Petr, Štádler, Jakub, Šetinová, Ivana, Novobílská, Jana, Lundelin, Krisa, Salminen, Seppo, Isolauri, Erika, Pitt, Tracy, Flanders, Tamar, Peñalver, Marcos, Martínez, Patricia, Lluch, Magdalena, Malet, Alfonso, Nam, Young-Hee, Jin, Hyun Jung, Lee, Soo-Keol, Kulalert, Prapasri, Sritipsukho, Paskorn, Pathumanond, Jayanton, Baynova, Krasimira, Labella, Marina, De Aramburu, Teresa, Prados, Manuel, Haanpää, Leena, Aarnio, Jasmin, Nermes, Merja, Af Ursin, Piia, Kaljonen, Anne, Bala, Nandana, Bhagwat, Ketaki, Hindley, James, Chapman, Martin, Baalasubramanian, Sivasankar, Besednjak-Kocijančič, Lilijana, SenGupta, Koyel, Antonova, Evgeniya, Kong, Amanda M, Iqbal, Ahmar, Teague, W Gerald, Trzaskoma, Benjamin, Ortiz, Benjamin, Paknis, Brandee, Iqbal, Amar, Rosen, Karin, Szefler, Stanley, Alblooshi, Afaf, Al-Hammadi, Suleiman, Vega, Arantza, Gutiérrez-Rivas, Raquel, Alonso, Ana Maria, Beitia, Juan Maria, Belén Mateo, Maria, Cárdenas, Remedios, García-Domínguez, Juan Jesús, Pitchon Dos Reis, Raquel, Gonçalves Alvim, Cristina, Andrade, Claudia, Reis, Adriana, Ribeiro, Henrique, Panaitescu Bunu, Carmen, Marusciac, Laura, Paralescu, Sorin, Tamas, Paul, Panitescu Bunu, Carmen, Martí Guadaño, Enrique, Escobar Bolaños, Carolina, Martí José, Natalia, Pau Casanovas, Pol, Biarnés Rib, Gemma, Castells, Mariana, de Vicente Jiménez, Talía, Mennini, Maurizio, De Angelis, Papola, Rea, Francesca, Malamisura, Monica, Tambucci, Renato, Dall'Oglio, Luigi, Del Chierico, Federica, Napolitano, Tania, Reddel, Silvia, Vernocchi, Pamela, D'Ambrosio, Angelo, Putignani, Lorenza, Dahdah, Lamia, Banzato, Claudia, Echeverría Zudaire, Luís Angel, Plaza, Ana María, Bosque García, Montserrat, Íbero, Marcel, Mazzina, Oscar, Marzano, Valeria, Pecora, Valeria, Koch, Pierluigi, Pecora, Valentina, Valentini, Diletta, Santamaria, Francesca, Valluzzi, Rocco, Mukherjee, Anwesha, Kandhare, Amit, and Bodhankar, Subhash

Published
2017

11. Proceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects

Author

Traina, Giovanni, Valluzzi, Rocco Luigi, Fierro, Vincenzo, Riccardi, Carla, Artesani, Maria Cristina, De Vuono, Andrea, Fiocchi, Alessandro, Martelli, Alberto G., Ríos, Luis Alberto, Alcocer, Christian R., Navarrete, Elsy, Del Rio Navarro, Blanca Estela, Gonzalez, Victor, Velasco, Berenice, Perez Aviles, Herberth J., Fernandez, Roberto Jose, Pozo, F. Cesar, Farhan, Abdal Jabbar, Arshad, Hasan, Hussain, Ahmed, Sharikadze, Olena, Okhotnikova, Olena, Alcover, Javier, Rodriguez, Diego, Pineda, Fernando, Dalal, Ilan, Weinbrand-Goichberg, Jenny, Benor, Shira, Rottem, Menachem, Kivity, Shmuel, Sato, Sakura, Yanagida, Noriyuki, Ebisawa, Motohiro, Umanets, Tetiana, Antipkin, Youriy, Barzylovich, Vladyslava, Lapshyn, Volodymyr, Umanets, Mykola, Yuriev, Sergey, Bekir, Suzan, Pincock, Tobias, Vieira Hernandez, Alberto, Capriles Hulett, Arnaldo, Sánchez Borges, Mario, Fabiano, Fabiola, Albarran, Carlos, Goyal, Rohit, Gupta, Shilpa, Gaurav, Garg, Luskin, Allan T., Griffin, Noelle M., Wagelie-Steffen, Amy, Trzaskoma, Benjamin L., Limb, Susan L., Busse, William W., Zeiger, Robert S., Gonzalez-Reyes, Erika, Casale, Thomas, Chipps, Bradley E., Sugizaki, Chizuko, Goto, Fumiko, Yamaide, Akiko, Mitsunaga, Kanako, Tomiita, Minako, Hoshioka, Akira, Shimojo, Naoki, Pop, Liviu L., Ciucǎ, Ioana-Mihaela, Tǎmaş, Liviu, Lazarescu, Marilena, Pienar, Corina, Yamaide, Fumiya, Fikri, Bahrul, Sato, Hironori, Okishima, Naoko, Kobayashi, Miyabi, Takai, Mizuki, Nishigata, Kotarou, Yoda, Ryou, Oana, Yu-ta, Kajiwara, Chifu, Shimodaira, Moe, Suzuki, Tomoka, Iizawa, Hiromi, Kamijo, Koji, Karmakar, Bijoya, Bhattacharya, Swati Gupta, Blohlávková, Simona, Kopelentová, Eliška, Víšek, Petr, Štádler, Jakub, Šetinová, Ivana, Novobílská, Jana, Lundelin, Krisa, Salminen, Seppo, Isolauri, Erika, Pitt, Tracy, Flanders, Tamar, Peñalver, Marcos, Martínez, Patricia, Lluch, Magdalena, Malet, Alfonso, Nam, Young-Hee, Jin, Hyun Jung, Lee, Soo-Keol, Kulalert, Prapasri, Sritipsukho, Paskorn, Pathumanond, Jayanton, Baynova, Krasimira, Labella, Marina, De Aramburu, Teresa, Prados, Manuel, Haanpää, Leena, Aarnio, Jasmin, Nermes, Merja, af Ursin, Piia, Kaljonen, Anne, Bala, Nandana, Bhagwat, Ketaki, Hindley, James, Chapman, Martin, Baalasubramanian, Sivasankar, Besednjak-Kocijančič, Lilijana, SenGupta, Koyel, Antonova, Evgeniya, Kong, Amanda M., Iqbal, Ahmar, Teague, W. Gerald, Trzaskoma, Benjamin, Ortiz, Benjamin, Paknis, Brandee, Iqbal, Amar, Rosen, Karin, Szefler, Stanley, Alblooshi, Afaf, Al-Hammadi, Suleiman, Vega, Arantza, Gutiérrez-Rivas, Raquel, Alonso, Ana Maria, Beitia, Juan Maria, Belén Mateo, Maria, Cárdenas, Remedios, García-Domínguez, Juan Jesús, Pitchon dos Reis, Raquel, Gonçalves Alvim, Cristina, Andrade, Claudia, Reis, Adriana, Ribeiro, Henrique, Panaitescu Bunu, Carmen, Marusciac, Laura, Paralescu, Sorin, Tamas, Paul, Panitescu Bunu, Carmen, Martí Guadaño, Enrique, Escobar Bolaños, Carolina, Martí José, Natalia, Pau Casanovas, Pol, Biarnés Rib, Gemma, Castells, Mariana, de Vicente Jiménez, Talía, Mennini, Maurizio, De Angelis, Papola, Rea, Francesca, Malamisura, Monica, Tambucci, Renato, Dall'Oglio, Luigi, Del Chierico, Federica, Napolitano, Tania, Reddel, Silvia, Vernocchi, Pamela, D'Ambrosio, Angelo, Putignani, Lorenza, Dahdah, Lamia, Banzato, Claudia, Echeverría Zudaire, Luís Angel, Plaza, Ana María, Bosque, Montserrat, Íbero, Marcel, Mazzina, Oscar, Marzano, Valeria, Pecora, Valeria, Koch, Pierluigi, Pecora, Valentina, Valentini, Diletta, Santamaria, Francesca, Mukherjee, Anwesha, Kandhare, Amit, Bodhankar, Subhash, and Universitat Autònoma de Barcelona

Subjects
lcsh:Immunologic diseases. Allergy, Pulmonary and Respiratory Medicine, business.industry, Immunology, MEDLINE, Library science, Meeting Abstracts, Vatican City, Hot topics, Immunology and Allergy, Medicine, lcsh:RC581-607, business
Published
2017

21. Safety of barley starch syrup in patients with allergy to cereals.

Author

Nermes, Merja, Karvonen, Henna, Sarkkinen, Essi, and Isolauri, Erika

Abstract

It is not known whether trace amounts of proteins that may remain in cereal-starch-derived food ingredients even after food processing can trigger allergic symptoms in cereal-allergic individuals. The aim of this study was to find out if barley starch syrup causes allergic reactions in patients with allergy to wheat, barley, rye or oats. Fifteen children with allergy to these cereals, confirmed by double-blind placebo-controlled food challenge (DBPCFC), were selected for the study. When exposed to cereals, seven of the children (47 %) showed immediate type reactions, such as urticaria, rash or anaphylaxis. Eight of the children (53 %) showed delayed type reactions, such as deterioration of atopic dermatitis or diarrhoea. The fifteen children with allergy to cereals were exposed to barley starch syrup in DBPCFC and none of them showed any objective signs of allergy. On skin-prick tests (SPT), five of the children (33·3 %) showed a positive ( ≥ 3 mm) reaction to at least one of the cereals but none of them to barley starch syrup. This study confirmed with 98 % confidence that at least 90 % of the patients with verified allergy to cereals will not react with allergic symptoms to barley starch syrup. [ABSTRACT FROM PUBLISHER]

Published
2009
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