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1. Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Author

Steering Committee, Landi, Francesco, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field investigators, Gastroenterology team, Porcari, Serena, Settanni, Carlo Romano, Geriatric team, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Ciciarello, Francesca, Fabrizi, Sofia, Galluzzo, Vincenzo, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco Cosimo, Pais, Cristina, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tosato, Matteo, Tritto, Marcello, Zazzara, Maria Beatrice, Calvani, Riccardo, Catalano, Lucio, Picca, Anna, Savera, Giulia, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, Giovanni, Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, Federica, Cacciatore, Stefano, Infectious disease team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, A., Di Gianbenedetto, Simona, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine team, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Zocco, M.A., Microbiology team, Sanguinetti, Maurizio, Cattani, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, M., Neurology team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, G., Cozzupoli, G.M., Culiersi, C., Otolaryngology team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Y., Tricarico, L., Santantonio, M., Pediatric team, Buonsenso, Danilo, Valentini, P., Pata, D., Sinatti, D., De Rose, C., Pneumology team, Richeldi, Luca, Lombardi, Francesco, Calabrese, A., Leone, Paolo Maria, Calvello, Maria Rosaria, Intini, Enrica, Montemurro, Giuliano, Psychiatric team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., odica, M., Radiology team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology team, Paglionico, Annamaria, Petricca, Luca, Gigante, Luca, Natalello, G., Fedele, A.L., Lizzio, M.M., Tolusso, B., Di Mario, Clara, Alivernini, S., Vascular team, Santoliquido, Angelo, Santoro, Luca, Di Giorgio, Angela, Nesci, Antonio, and Popolla, V.

Published
2022
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4. Role of Endothelium in Cardiovascular Sequelae of Long COVID

Author

Santoro, Luca, primary, Zaccone, Vincenzo, additional, Falsetti, Lorenzo, additional, Ruggieri, Vittorio, additional, Danese, Martina, additional, Miro, Chiara, additional, Di Giorgio, Angela, additional, Nesci, Antonio, additional, D’Alessandro, Alessia, additional, Moroncini, Gianluca, additional, and Santoliquido, Angelo, additional

Published
2023
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6. Malnutrition in COVID-19 survivors: prevalence and risk factors

Author

Tosato, Matteo, Calvani, Riccardo, Ciciarello, Francesca, Galluzzo, Vincenzo, Martone, Anna Maria, Zazzara, Maria Beatrice, Pais, Cristina, Savera, Giulia, Camprubi Robles, Maria, Ramirez, Maria, Landi, Francesco, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Romano Settanni, Carlo, Porcari, Serena, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Rita Lo Monaco, Maria, Maria Martone, Anna, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tritto, Marcello, Beatrice Zazzara, Maria, Catalano, Lucio, Picca, Anna, D’Elia, Mariaelena, Biscotti, Damiano, Cauda, Roberto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, Davide, Ciccullo, Arturo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Assunta Zocco, Maria, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Bizzarro, Alessandra, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Maria Cozzupoli, Grazia, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, Giovanni, Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Di Cesare, Tiziana, Guarino, Mariateresa, Corbò, Marco, Settimi, Stefano, Mele, Dario, Brigato, Francesca, Buonsenso, Danilo, Valentini, Piero, Sinatti, Dario, De Rose, Gabriella, Richeldi, Luca, Lombardi, Francesco, Calabrese, Angelo, Varone, Francesco, Maria Leone, Paolo, Siciliano, Matteo, Corbo, Giuseppe Maria, Montemurro, Giuliano, Calvello, Mariarosaria, Intini, Enrica, Simonetti, Jacopo, Pasciuto, Giuliana, Adiletta, Veronica, Sofia, Carmelo, Angela Licata, Maria, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Modica, Marco, Silvia, Montanari, Catinari, Antonello, Terenzi, Beatrice, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Pirronti, Tommaso, Infante, Amato, Paglionico, Annamaria, Petricca, Luca, Tolusso, Barbara, Alivernini, Stefano, Di Mario, Clara, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Di Giorgio, Angela, D’Alessandro, Alessia, Matteo Tosato, Riccardo Calvani (ORCID:0000-0001-5472-2365), Francesca Ciciarello, Vincenzo Galluzzo, Anna Maria Martone, Maria Beatrice Zazzara, Giulia Savera, Francesco Landi (ORCID:0000-0002-3472-1389), Elisa Gremese (ORCID:0000-0002-2248-1058), Roberto Bernabei (ORCID:0000-0002-9197-004X), Massimo Fantoni (ORCID:0000-0001-6913-8460), Emanuele Marzetti (ORCID:0000-0001-9567-6983), Roberto Cauda (ORCID:0000-0002-1498-4229), Giulio Ventura (ORCID:0000-0002-0304-7264), Giovanni Addolorato (ORCID:0000-0002-1522-9946), Francesco Franceschi (ORCID:0000-0001-6266-445X), Maurizio Sanguinetti (ORCID:0000-0002-9780-7059), Paola Cattani (ORCID:0000-0003-4678-4763), Brunella Posteraro (ORCID:0000-0002-1663-7546), Stanislao Rizzo (ORCID:0000-0001-6302-063X), Maria Cristina Savastano (ORCID:0000-0003-1397-4333), Giulio Cesare Passali (ORCID:0000-0002-8176-0962), Jacopo Galli (ORCID:0000-0001-6353-6249), Piero Valentini (ORCID:0000-0001-6095-9510), Luca Richeldi (ORCID:0000-0001-8594-1448), Giuseppe Maria Corbo (ORCID:0000-0002-8104-4659), Gabriele Sani (ORCID:0000-0002-9767-8752), Luigi Natale (ORCID:0000-0002-7949-5119), Anna Rita Larici (ORCID:0000-0002-1882-6244), Riccardo Marano (ORCID:0000-0003-2710-2093), Stefano Alivernini (ORCID:0000-0002-7383-4212), Angelo Santoliquido (ORCID:0000-0003-1539-4017), Tosato, Matteo, Calvani, Riccardo, Ciciarello, Francesca, Galluzzo, Vincenzo, Martone, Anna Maria, Zazzara, Maria Beatrice, Pais, Cristina, Savera, Giulia, Camprubi Robles, Maria, Ramirez, Maria, Landi, Francesco, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Romano Settanni, Carlo, Porcari, Serena, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Rita Lo Monaco, Maria, Maria Martone, Anna, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tritto, Marcello, Beatrice Zazzara, Maria, Catalano, Lucio, Picca, Anna, D’Elia, Mariaelena, Biscotti, Damiano, Cauda, Roberto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, Davide, Ciccullo, Arturo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Assunta Zocco, Maria, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Bizzarro, Alessandra, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Maria Cozzupoli, Grazia, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, Giovanni, Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Di Cesare, Tiziana, Guarino, Mariateresa, Corbò, Marco, Settimi, Stefano, Mele, Dario, Brigato, Francesca, Buonsenso, Danilo, Valentini, Piero, Sinatti, Dario, De Rose, Gabriella, Richeldi, Luca, Lombardi, Francesco, Calabrese, Angelo, Varone, Francesco, Maria Leone, Paolo, Siciliano, Matteo, Corbo, Giuseppe Maria, Montemurro, Giuliano, Calvello, Mariarosaria, Intini, Enrica, Simonetti, Jacopo, Pasciuto, Giuliana, Adiletta, Veronica, Sofia, Carmelo, Angela Licata, Maria, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Modica, Marco, Silvia, Montanari, Catinari, Antonello, Terenzi, Beatrice, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Pirronti, Tommaso, Infante, Amato, Paglionico, Annamaria, Petricca, Luca, Tolusso, Barbara, Alivernini, Stefano, Di Mario, Clara, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Di Giorgio, Angela, D’Alessandro, Alessia, Matteo Tosato, Riccardo Calvani (ORCID:0000-0001-5472-2365), Francesca Ciciarello, Vincenzo Galluzzo, Anna Maria Martone, Maria Beatrice Zazzara, Giulia Savera, Francesco Landi (ORCID:0000-0002-3472-1389), Elisa Gremese (ORCID:0000-0002-2248-1058), Roberto Bernabei (ORCID:0000-0002-9197-004X), Massimo Fantoni (ORCID:0000-0001-6913-8460), Emanuele Marzetti (ORCID:0000-0001-9567-6983), Roberto Cauda (ORCID:0000-0002-1498-4229), Giulio Ventura (ORCID:0000-0002-0304-7264), Giovanni Addolorato (ORCID:0000-0002-1522-9946), Francesco Franceschi (ORCID:0000-0001-6266-445X), Maurizio Sanguinetti (ORCID:0000-0002-9780-7059), Paola Cattani (ORCID:0000-0003-4678-4763), Brunella Posteraro (ORCID:0000-0002-1663-7546), Stanislao Rizzo (ORCID:0000-0001-6302-063X), Maria Cristina Savastano (ORCID:0000-0003-1397-4333), Giulio Cesare Passali (ORCID:0000-0002-8176-0962), Jacopo Galli (ORCID:0000-0001-6353-6249), Piero Valentini (ORCID:0000-0001-6095-9510), Luca Richeldi (ORCID:0000-0001-8594-1448), Giuseppe Maria Corbo (ORCID:0000-0002-8104-4659), Gabriele Sani (ORCID:0000-0002-9767-8752), Luigi Natale (ORCID:0000-0002-7949-5119), Anna Rita Larici (ORCID:0000-0002-1882-6244), Riccardo Marano (ORCID:0000-0003-2710-2093), Stefano Alivernini (ORCID:0000-0002-7383-4212), and Angelo Santoliquido (ORCID:0000-0003-1539-4017)

Abstract

Background: Nutritional status is a critical factor throughout COVID-19 disease course. Malnutrition is associated with poor outcomes in hospitalized COVID-19 patients. Aim: To assess the prevalence of malnutrition and identify its associated factors in COVID-19 survivors. Methods: Study cohort included 1230 COVID-19 survivors aged 18-86 attending a post-COVID-19 outpatient service. Data on clinical parameters, anthropometry, acute COVID-19 symptoms, lifestyle habits were collected through a comprehensive medical assessment. Malnutrition was assessed according to Global Leadership Initiative on Malnutrition (GLIM) criteria. Results: Prevalence of malnutrition was 22% at 4-5 months after acute disease. Participants who were not hospitalized during acute COVID-19 showed a higher frequency of malnutrition compared to those who needed hospitalization (26% versus 19%, p < 0.01). Malnutrition was found in 25% COVID-19 survivors over 65 years of age compared to 21% younger participants (p < 0.01). After multivariable adjustment, the likelihood of being malnourished increased progressively and independently with advancing age (Odds ratio [OR] 1.02; 95% CI 1.01-1.03) and in male participants (OR 5.56; 95% CI 3.53-8.74). Malnutrition was associated with loss of appetite (OR 2.50; 95% CI 1.73-3.62), and dysgeusia (OR 4.05; 95% CI 2.30-7.21) during acute COVID-19. Discussion: In the present investigation we showed that malnutrition was highly prevalent in a large cohort of COVID-19 survivors at 4-5 months from acute illness. Conclusions: Our findings highlight the need to implement comprehensive nutritional assessment and therapy as an integral part of care for COVID-19 patients.

Published
2023

7. Gut Microbiota and Cardiovascular Disease: Evidence on the Metabolic and Inflammatory Background of a Complex Relationship

Author

Nesci, Antonio, Carnuccio, Claudia, Ruggieri, Vittorio, D'Alessandro, Alessia, Di Giorgio, Angela, Santoro, Luca, Gasbarrini, Antonio, Santoliquido, Angelo, Ponziani, Francesca Romana, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), Ponziani, Francesca Romana (ORCID:0000-0002-5924-6238), Nesci, Antonio, Carnuccio, Claudia, Ruggieri, Vittorio, D'Alessandro, Alessia, Di Giorgio, Angela, Santoro, Luca, Gasbarrini, Antonio, Santoliquido, Angelo, Ponziani, Francesca Romana, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), and Ponziani, Francesca Romana (ORCID:0000-0002-5924-6238)

Abstract

Several studies in recent years have demonstrated that gut microbiota-host interactions play an important role in human health and disease, including inflammatory and cardiovascular diseases. Dysbiosis has been linked to not only well-known inflammatory diseases, such as inflammatory bowel diseases, rheumatoid arthritis, and systemic lupus erythematous, but also to cardiovascular risk factors, such as atherosclerosis, hypertension, heart failure, chronic kidney disease, obesity, and type 2 diabetes mellitus. The ways the microbiota is involved in modulating cardiovascular risk are multiple and not only related to inflammatory mechanisms. Indeed, human and the gut microbiome cooperate as a metabolically active superorganism, and this affects host physiology through metabolic pathways. In turn, congestion of the splanchnic circulation associated with heart failure, edema of the intestinal wall, and altered function and permeability of the intestinal barrier result in the translocation of bacteria and their products into the systemic circulation, further enhancing the pro-inflammatory conditions underlying cardiovascular disorders. The aim of the present review is to describe the complex interplay between gut microbiota, its metabolites, and the development and evolution of cardiovascular diseases. We also discuss the possible interventions intended to modulate the gut microbiota to reduce cardiovascular risk.

Published
2023

9. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial

Author

Tosato, Matteo, primary, Calvani, Riccardo, additional, Picca, Anna, additional, Ciciarello, Francesca, additional, Galluzzo, Vincenzo, additional, Coelho-Júnior, Hélio José, additional, Di Giorgio, Angela, additional, Di Mario, Clara, additional, Gervasoni, Jacopo, additional, Gremese, Elisa, additional, Leone, Paolo Maria, additional, Nesci, Antonio, additional, Paglionico, Anna Maria, additional, Santoliquido, Angelo, additional, Santoro, Luca, additional, Santucci, Lavinia, additional, Tolusso, Barbara, additional, Urbani, Andrea, additional, Marini, Federico, additional, Marzetti, Emanuele, additional, and Landi, Francesco, additional

Published
2022
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10. High prevalence of lower limb atherosclerosis is linked with the gut–liver axis in patients with primary biliary cholangitis

Author

Ponziani, Francesca Romana, primary, Nesci, Antonio, additional, Caputo, Camilla, additional, Salvatore, Lucia, additional, Picca, Anna, additional, Del Chierico, Federica, additional, Paroni Sterbini, Francesco, additional, Marzetti, Emanuele, additional, Di Giorgio, Angela, additional, Santoro, Luca, additional, Putignani, Lorenza, additional, Gasbarrini, Antonio, additional, Santoliquido, Angelo, additional, and Pompili, Maurizio, additional

Published
2022
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11. Radial Peripapillary Capillary Plexus Perfusion and Endothelial Dysfunction in Early Post-SARS-CoV-2 Infection

Author

Savastano, Maria Cristina, Santoro, Luca, Crincoli, Emanuele, Fossataro, Claudia, Gambini, Gloria, Savastano, Alfonso, De Vico, Umberto, Santoliquido, Angelo, Nesci, Antonio, Landi, Francesco, Rizzo, Stanislao, Savastano M. C. (ORCID:0000-0003-1397-4333), Santoro L., Crincoli E., Fossataro C., Gambini G., Savastano A., De Vico U., Santoliquido A. (ORCID:0000-0003-1539-4017), Nesci A., Landi F. (ORCID:0000-0002-3472-1389), Rizzo S. (ORCID:0000-0001-6302-063X), Savastano, Maria Cristina, Santoro, Luca, Crincoli, Emanuele, Fossataro, Claudia, Gambini, Gloria, Savastano, Alfonso, De Vico, Umberto, Santoliquido, Angelo, Nesci, Antonio, Landi, Francesco, Rizzo, Stanislao, Savastano M. C. (ORCID:0000-0003-1397-4333), Santoro L., Crincoli E., Fossataro C., Gambini G., Savastano A., De Vico U., Santoliquido A. (ORCID:0000-0003-1539-4017), Nesci A., Landi F. (ORCID:0000-0002-3472-1389), and Rizzo S. (ORCID:0000-0001-6302-063X)

Abstract

Background: Endothelial cells damage and thromboinflammation are considered key elements in the generation of organ impairment in patients with COVID-19 disease. The endothelial function is evaluated by measuring flow-mediated dilation (FMD). We aimed to analyze the association between FMD impairment and retinal vascular parameters in early post-COVID-19 patients. 00118-00199Tomography (OCT), OCT Angiography (OCTA) and slit lamp examination were performed. FMD ≤ 7% was considered as pathological. Our primary outcome was to assess potential differences in the radial peripapillary capillary plexus flow index (RPCP-FI) and RPCP density (RPCP-D) values between post-COVID-19 patients with and without FMD impairment. The associations of other retinal vascular parameters with FMD impairment were assessed as secondary endpoints. Results: FMD impairment was detected in 31 patients (37.8%). RPCP-FI (p = 0.047), age (p = 0.048) and prevalence of diabetes (p = 0.046) significantly differed in patients with FMD ≤ 7% in regression analysis. RPCP-FI was linearly correlated with FMD values (R = 0.244, p =0.027). SCT was found to be lower in patients with impaired FMD (p = 0.004), although this difference was only a trend in binary logistic regression output (p = 0.07). Conclusions: Early post-COVID-19 patients showed a higher prevalence of FMD impairment compared to the general population. Age, diabetes and RPCP-FI were independently correlated with the presence of endothelial impairment in the early post-infective period.

Published
2022

12. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial

Author

Tosato, Matteo, Calvani, Riccardo, Picca, A., Ciciarello, Francesca, Galluzzo, Vincenzo, Coelho-Junior, H. J., Di Giorgio, Angela, Di Mario, Clara, Gervasoni, Jacopo, Gremese, Elisa, Leone, Paolo Maria, Nesci, Antonio, Paglionico, A. M., Santoliquido, Angelo, Santoro, Luca, Santucci, Lavinia, Tolusso, Barbara, Urbani, Andrea, Marini, F., Marzetti, Emanuele, Landi, Francesco, Tosato M., Calvani R. (ORCID:0000-0001-5472-2365), Ciciarello F., Galluzzo V., Di Giorgio A., Di Mario C., Gervasoni J., Gremese E. (ORCID:0000-0002-2248-1058), Leone P. M., Nesci A., Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro L., Santucci L., Tolusso B. (ORCID:0000-0002-9108-6609), Urbani A. (ORCID:0000-0001-9168-3174), Marzetti E. (ORCID:0000-0001-9567-6983), Landi F. (ORCID:0000-0002-3472-1389), Tosato, Matteo, Calvani, Riccardo, Picca, A., Ciciarello, Francesca, Galluzzo, Vincenzo, Coelho-Junior, H. J., Di Giorgio, Angela, Di Mario, Clara, Gervasoni, Jacopo, Gremese, Elisa, Leone, Paolo Maria, Nesci, Antonio, Paglionico, A. M., Santoliquido, Angelo, Santoro, Luca, Santucci, Lavinia, Tolusso, Barbara, Urbani, Andrea, Marini, F., Marzetti, Emanuele, Landi, Francesco, Tosato M., Calvani R. (ORCID:0000-0001-5472-2365), Ciciarello F., Galluzzo V., Di Giorgio A., Di Mario C., Gervasoni J., Gremese E. (ORCID:0000-0002-2248-1058), Leone P. M., Nesci A., Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro L., Santucci L., Tolusso B. (ORCID:0000-0002-9108-6609), Urbani A. (ORCID:0000-0001-9168-3174), Marzetti E. (ORCID:0000-0001-9567-6983), and Landi F. (ORCID:0000-0002-3472-1389)

Abstract

Long COVID, a condition characterized by symptom and/or sign persistence following an acute COVID-19 episode, is associated with reduced physical performance and endothelial dysfunction. Supplementation of l-arginine may improve endothelial and muscle function by stimulating nitric oxide synthesis. A single-blind randomized, placebo-controlled trial was conducted in adults aged between 20 and 60 years with persistent fatigue attending a post-acute COVID-19 outpatient clinic. Participants were randomized 1:1 to receive twice-daily orally either a combination of 1.66 g l-arginine plus 500 mg liposomal vitamin C or a placebo for 28 days. The primary outcome was the distance walked on the 6 min walk test. Secondary outcomes were handgrip strength, flow-mediated dilation, and fatigue persistence. Fifty participants were randomized to receive either l-arginine plus vitamin C or a placebo. Forty-six participants (median (interquartile range) age 51 (14), 30 [65%] women), 23 per group, received the intervention to which they were allocated and completed the study. At 28 days, l-arginine plus vitamin C increased the 6 min walk distance (+30 (40.5) m; placebo: +0 (75) m, p = 0.001) and induced a greater improvement in handgrip strength (+3.4 (7.5) kg) compared with the placebo (+1 (6.6) kg, p = 0.03). The flow-mediated dilation was greater in the active group than in the placebo (14.3% (7.3) vs. 9.4% (5.8), p = 0.03). At 28 days, fatigue was reported by two participants in the active group (8.7%) and 21 in the placebo group (80.1%; p < 0.0001). l-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population.

Published
2022

13. Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Author

Galluzzo, Vincenzo, Zazzara, M. B., Ciciarello, Francesca, Savera, Giulia, Pais, C., Calvani, Riccardo, Picca, A., Marzetti, Emanuele, Landi, Francesco, Tosato, Matteo, Steering, Committee, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field, Investigator, Gastroenterology, Team, Porcari, Serena, Settanni, Carlo Romano, Geriatric, Team, Benvenuto, F., Bramato, Giulia, Brandi, Vincenzo, Carfi, A., Fabrizi, Sofia, Lo Monaco, Maria Rita, Martone, Anna Maria, Napolitano, C., Pagano, Francesco Cosimo, Rocchi, Sara, Rota, E., Salerno, Andrea Maria, Tritto, M., Catalano, Lucio, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, Giovanni, Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, Federica, Cacciatore, Stefano, Infectious disease, Team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, Alberto, Di Gianbenedetto, S., Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine, Team, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Microbiology, Team, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Neurology, Team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology, Team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, G. M., Culiersi, Carola, Otolaryngology, Team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Ylenia, Tricarico, Laura, Santantonio, M., Pediatric, Team, Buonsenso, Danilo, Valentini, Piero, Pata, D., Sinatti, Dario, De Rose, Cristina, Pneumology, Team, Richeldi, Luca, Lombardi, Francesco, Calabrese, Anna Chiara, Leone, Paolo Maria, Calvello, M. R., Intini, Enrica, Montemurro, G., Psychiatric, Team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., Odica, M., Radiology, Team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology, Team, Paglionico, A., Petricca, Luca, Gigante, Lavinia, Natalello, G., Fedele, Anna Laura, Lizzio, Marco Maria, Tolusso, Barbara, Di Mario, Clara, Alivernini, Stefano, Vascular, Team, Santoliquido, Angelo, Santoro, Luca, Di Giorgio, Angela, Nesci, Antonio, Popolla, Valentina, Galluzzo V., Ciciarello F., Savera G., Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Landi F. (ORCID:0000-0002-3472-1389), Tosato M., Gremese E. (ORCID:0000-0002-2248-1058), Bernabei R. (ORCID:0000-0002-9197-004X), Fantoni M. (ORCID:0000-0001-6913-8460), Gasbarrini A. (ORCID:0000-0002-7278-4823), Porcari S., Settanni C. R., Bramato G., Brandi V., Fabrizi S., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Martone A. M., Pagano F. C., Rocchi S., Salerno A., Catalano L., Damiano F. P., Rocconi A., Galliani A., Spaziani G., Tupputi S., Cocchi C., Pirone F., D'Ignazio F., Cacciatore S., Cauda R. (ORCID:0000-0002-1498-4229), Tamburrini E. (ORCID:0000-0003-4930-426X), Borghetti A., Murri R. (ORCID:0000-0003-4263-7854), Cingolani A. (ORCID:0000-0002-3793-2755), Ventura G. (ORCID:0000-0002-0304-7264), Stella L., Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Mingrone G. (ORCID:0000-0003-2021-528X), Zocco M. A. (ORCID:0000-0002-0814-9542), Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Marchetti S., Posteraro B. (ORCID:0000-0002-1663-7546), Sali M. (ORCID:0000-0003-3609-2990), Bizzarro A., Lauria A., Rizzo S. (ORCID:0000-0001-6302-063X), Savastano M. C. (ORCID:0000-0003-1397-4333), Gambini G., Culiersi C., Passali G. C. (ORCID:0000-0002-8176-0962), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Longobardi Y., Tricarico L., Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), Sinatti D., De Rose C., Richeldi L. (ORCID:0000-0001-8594-1448), Lombardi F., Calabrese A., Leone P. M., Intini E., Sani G. (ORCID:0000-0002-9767-8752), Janiri D., Simonetti A., Natale L. (ORCID:0000-0002-7949-5119), Larici A. R. (ORCID:0000-0002-1882-6244), Marano R. (ORCID:0000-0003-2710-2093), Petricca L., Gigante L., Fedele A. L., Lizzio M. M., Tolusso B. (ORCID:0000-0002-9108-6609), Di Mario C., Alivernini S. (ORCID:0000-0002-7383-4212), Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro L., Di Giorgio A., Nesci A., Popolla V., Galluzzo, Vincenzo, Zazzara, M. B., Ciciarello, Francesca, Savera, Giulia, Pais, C., Calvani, Riccardo, Picca, A., Marzetti, Emanuele, Landi, Francesco, Tosato, Matteo, Steering, Committee, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field, Investigator, Gastroenterology, Team, Porcari, Serena, Settanni, Carlo Romano, Geriatric, Team, Benvenuto, F., Bramato, Giulia, Brandi, Vincenzo, Carfi, A., Fabrizi, Sofia, Lo Monaco, Maria Rita, Martone, Anna Maria, Napolitano, C., Pagano, Francesco Cosimo, Rocchi, Sara, Rota, E., Salerno, Andrea Maria, Tritto, M., Catalano, Lucio, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, Giovanni, Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, Federica, Cacciatore, Stefano, Infectious disease, Team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, Alberto, Di Gianbenedetto, S., Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine, Team, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Microbiology, Team, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Neurology, Team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology, Team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, G. M., Culiersi, Carola, Otolaryngology, Team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Ylenia, Tricarico, Laura, Santantonio, M., Pediatric, Team, Buonsenso, Danilo, Valentini, Piero, Pata, D., Sinatti, Dario, De Rose, Cristina, Pneumology, Team, Richeldi, Luca, Lombardi, Francesco, Calabrese, Anna Chiara, Leone, Paolo Maria, Calvello, M. R., Intini, Enrica, Montemurro, G., Psychiatric, Team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., Odica, M., Radiology, Team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology, Team, Paglionico, A., Petricca, Luca, Gigante, Lavinia, Natalello, G., Fedele, Anna Laura, Lizzio, Marco Maria, Tolusso, Barbara, Di Mario, Clara, Alivernini, Stefano, Vascular, Team, Santoliquido, Angelo, Santoro, Luca, Di Giorgio, Angela, Nesci, Antonio, Popolla, Valentina, Galluzzo V., Ciciarello F., Savera G., Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Landi F. (ORCID:0000-0002-3472-1389), Tosato M., Gremese E. (ORCID:0000-0002-2248-1058), Bernabei R. (ORCID:0000-0002-9197-004X), Fantoni M. (ORCID:0000-0001-6913-8460), Gasbarrini A. (ORCID:0000-0002-7278-4823), Porcari S., Settanni C. R., Bramato G., Brandi V., Fabrizi S., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Martone A. M., Pagano F. C., Rocchi S., Salerno A., Catalano L., Damiano F. P., Rocconi A., Galliani A., Spaziani G., Tupputi S., Cocchi C., Pirone F., D'Ignazio F., Cacciatore S., Cauda R. (ORCID:0000-0002-1498-4229), Tamburrini E. (ORCID:0000-0003-4930-426X), Borghetti A., Murri R. (ORCID:0000-0003-4263-7854), Cingolani A. (ORCID:0000-0002-3793-2755), Ventura G. (ORCID:0000-0002-0304-7264), Stella L., Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Mingrone G. (ORCID:0000-0003-2021-528X), Zocco M. A. (ORCID:0000-0002-0814-9542), Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Marchetti S., Posteraro B. (ORCID:0000-0002-1663-7546), Sali M. (ORCID:0000-0003-3609-2990), Bizzarro A., Lauria A., Rizzo S. (ORCID:0000-0001-6302-063X), Savastano M. C. (ORCID:0000-0003-1397-4333), Gambini G., Culiersi C., Passali G. C. (ORCID:0000-0002-8176-0962), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Longobardi Y., Tricarico L., Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), Sinatti D., De Rose C., Richeldi L. (ORCID:0000-0001-8594-1448), Lombardi F., Calabrese A., Leone P. M., Intini E., Sani G. (ORCID:0000-0002-9767-8752), Janiri D., Simonetti A., Natale L. (ORCID:0000-0002-7949-5119), Larici A. R. (ORCID:0000-0002-1882-6244), Marano R. (ORCID:0000-0003-2710-2093), Petricca L., Gigante L., Fedele A. L., Lizzio M. M., Tolusso B. (ORCID:0000-0002-9108-6609), Di Mario C., Alivernini S. (ORCID:0000-0002-7383-4212), Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro L., Di Giorgio A., Nesci A., and Popolla V.

Abstract

Background: Fatigue with reduced tolerance to exercise is a common persistent long-lasting feature amongst COVID-19 survivors. The assessment of muscle function in this category of patients is often neglected. Aim.: To evaluate the potential impact of a daily supplementation based on amino acids, minerals, vi- tamins, and plant extracts (Apportal®) on muscle function, body composition, laboratory parameters and self-rated health in a small group of COVID-19 survivors affected by fatigue. Methods: Thirty participants were enrolled among patients affected by physical fatigue during or after acute COVID-19 and admitted to the post-COVID-19 outpatient service at Fondazione Policlinico Gemelli in Rome between 1st March 2021 and 30th April 2021. All participants were evaluated at first visit (t0) and at control visit (t1), after taking a daily sachet of Apportal® for 28 days. Muscle function was analyzed using hand grip strength test, exhaustion strength time and the number of repetitions at one- minute chair stand test. Body composition was assessed with bioelectrical impedance analysis (BIA). Laboratory parameters, including standard blood biochemistry and ferritin levels, were evaluated at the first visit and during the control visit. A quick evaluation of self-rated health, before COVID-19, at t0 and t1, was obtained through a visual analogue scale (VAS). Results: Participants aged 60 years and older were 13 (43%). Females represented the 70% of the study sample. Participants hospitalized for COVID-19 with low-flow oxygen supplementation represented the 43.3% of the study sample while 3.3% received noninvasive ventilation (NIV) or invasive ventilation. Hand grip strength improved from 26.3 Kg to 28.9 Kg (p < 0.05) at t1 as compared to t0. The mean time of strength exhaustion increased from 31.7 s (sec) at t0 to 47.5 s at t1 (p < 0.05). Participants performed a higher number of repetitions (28.3 vs. 22.0; p < 0.05) during the one-minute chair stand test at t1

Published
2022

14. High prevalence of lower limb atherosclerosis is linked with the gut–liver axis in patients with primary biliary cholangitis

Author

Ponziani, Francesca Romana, Nesci, Antonio, Caputo, C., Salvatore, L., Picca, A., Del Chierico, F., Paroni Sterbini, F., Marzetti, Emanuele, Di Giorgio, Angela, Santoro, Luca, Putignani, Lorenza, Gasbarrini, Antonio, Santoliquido, Angelo, Pompili, Maurizio, Ponziani F. R. (ORCID:0000-0002-5924-6238), Nesci A., Marzetti E. (ORCID:0000-0001-9567-6983), Di Giorgio A., Santoro L., Putignani L., Gasbarrini A. (ORCID:0000-0002-7278-4823), Santoliquido A. (ORCID:0000-0003-1539-4017), Pompili M. (ORCID:0000-0001-6699-7980), Ponziani, Francesca Romana, Nesci, Antonio, Caputo, C., Salvatore, L., Picca, A., Del Chierico, F., Paroni Sterbini, F., Marzetti, Emanuele, Di Giorgio, Angela, Santoro, Luca, Putignani, Lorenza, Gasbarrini, Antonio, Santoliquido, Angelo, Pompili, Maurizio, Ponziani F. R. (ORCID:0000-0002-5924-6238), Nesci A., Marzetti E. (ORCID:0000-0001-9567-6983), Di Giorgio A., Santoro L., Putignani L., Gasbarrini A. (ORCID:0000-0002-7278-4823), Santoliquido A. (ORCID:0000-0003-1539-4017), and Pompili M. (ORCID:0000-0001-6699-7980)

Abstract

Background and Aims Hypercholesterolemia is frequent in people with primary biliary cholangitis (PBC); however, it does not seem to confer an increased risk of cardiovascular disease. We aimed to evaluate the prevalence of peripheral arterial disease in PBC women and its association with the gut-liver axis and systemic inflammation. Methods Thirty patients affected by PBC and hypercholesterolemia were enrolled, with equal-sized groups of women with non-alcoholic fatty liver disease (NAFLD) and healthy controls (CTRL). All patients underwent Doppler ultrasound examination of peripheral arteries, assessment of flow-mediated dilation, quantification of circulating cytokines and vasoactive mediators and characterization of the gut microbiota. Results PBC patients had a higher prevalence of lower extremity arterial disease (LEAD) defined as atherosclerotic plaques in any of femoral, popliteal and/or tibial arteries compared with both NAFLD and CTRL women (83.3% vs. 53.3% and 50%, respectively; p = .01). Factors associated with LEAD at univariate analysis were VCAM-1 (p = .002), ICAM-1 (p = .003), and TNF-alpha (p = .04) serum levels, but only VCAM-1 (OR 1.1, 95% CI 1.0-1.1; p = .04) and TNF-alpha (OR 1.12, 95% CI 0.99-1.26; p = .04) were confirmed as independent predictors in the multivariate model. Gut microbiota analysis revealed that Acidaminococcus (FDR = 0.0008), Bifidobacterium (FDR = 0.001) and Oscillospira (FDR = 0.03) were differentially expressed among groups. Acidaminococcus, which was increased in PBC, was positively correlated with TNF-alpha serum levels. Down-regulation of metabolic pathways linked to fatty acid and butyrate metabolism, glyoxylate metabolism and branched-chain amino acids degradation was found in the functional gut metagenome of PBC women. Conclusions LEAD is common in patients affected by PBC and is associated with inflammatory markers and alterations in the gut-liver axis.

Published
2022

15. Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study

Author

Santoro, Luca, Falsetti, L., Zaccone, V., Nesci, Antonio, Tosato, Matteo, Giupponi, B., Savastano, Maria Cristina, Moroncini, G., Gasbarrini, Antonio, Landi, Francesco, Santoliquido, Angelo, Santoro L., Nesci A., Tosato M., Savastano M. C. (ORCID:0000-0003-1397-4333), Gasbarrini A. (ORCID:0000-0002-7278-4823), Landi F. (ORCID:0000-0002-3472-1389), Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro, Luca, Falsetti, L., Zaccone, V., Nesci, Antonio, Tosato, Matteo, Giupponi, B., Savastano, Maria Cristina, Moroncini, G., Gasbarrini, Antonio, Landi, Francesco, Santoliquido, Angelo, Santoro L., Nesci A., Tosato M., Savastano M. C. (ORCID:0000-0003-1397-4333), Gasbarrini A. (ORCID:0000-0002-7278-4823), Landi F. (ORCID:0000-0002-3472-1389), and Santoliquido A. (ORCID:0000-0003-1539-4017)

Abstract

Background: Endothelial dysfunction has a role in acute COVID-19, contributing to systemic inflammatory syndrome, acute respiratory distress syndrome, and vascular events. Evidence regarding COVID-19 middle-and long-term consequences on endothelium are still lacking. Our study aimed to evaluate if COVID-19 severity could significantly affect the endothelial function after three months from the acute phase. Methods: We assessed endothelial function in outpatients with previous COVID-19 three months after negative SARS-CoV-2 molecular test by measuring flow-mediated dilation (FMD) in patients categorized according to a four-variable COVID-19 severity scale (“home care”; “hospital, no oxygen”; “hospital, oxygen”; “hospital requiring high-flow nasal canula, non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation”). FMD difference among COVID-19 severity categories was assessed with analysis of variance; we further clarified the relationship between FMD and previous COVID-19 severity with multivariate logistic models. Results: Among 658 consecutive COVID-19 subjects, we observed a significant linear trend of FMD reduction with the increase of the COVID-19 category (p < 0.0001). The presence of endothelial dysfunction was more frequent among hospitalized patients (78.3%) with respect to home-care patients (21.7%; p < 0.0001). COVID-19 severity was associated with increased endothelial dysfunction risk (OR: 1.354; 95% CI: 1.06–1.71; p = 0.011) at multivariate binary logistic analysis. FMD showed a significant direct correlation with PaO2 (p = 0.004), P/F ratio (p = 0.004), FEV1 (p = 0.008), and 6MWT (p = 0.0001). Conclusions: Hospitalized COVID-19 subjects showed an impaired endothelial function three months after the acute phase that correlated with pulmonary function impairment. Further studies are needed to evaluate if these subjects are at higher risk of developing pulmonary disease or future cardiovascular events.

Published
2022

16. COVID-19 atypical Parsonage-Turner syndrome: a case report

Author

Zazzara, Maria Beatrice, Modoni, Anna, Bizzarro, Alessandra, Lauria, Alessandra, Ciciarello, Francesca, Pais, Cristina, Galluzzo, Vincenzo, Landi, Francesco, Tostato, Matteo, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Porcari, Serena, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea Maria, Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Picca, Anna, Savera, Giulia, Cauda, Roberto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, Davide, Ciccullo, Arturo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Zocco, Maria Assunta, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, Maria Grazia, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, Giovanni, Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Di Cesare, Tiziana, Guarino, Mariateresa, Corbò, Marco, Settimi, Stefano, Mele, Dario Antonio, Brigato, Francesca, Buonsenso, Danilo, Valentini, Piero, Sinatti, Dario, De Rose, Gabriella, Richeldi, Luca, Lombardi, Francesco, Calabrese, Angelo, Varone, Francesco, Leone, Paolo Maria, Siciliano, Matteo, Corbo, Giuseppe Maria, Montemurro, Giuliano, Calvello, Mariarosaria, Intini, Enrica, Simonetti, Jacopo, Pasciuto, Giuliana, Adiletta, Veronica, Sofia, Carmelo, Licata, Maria Angela Vittoria Anna Chiara, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Modica, Marco, Montanari, Silvia, Catinari, Antonello, Terenzi, Beatrice, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Pirronti, Tommaso, Infante, Amato, Paglionico, Annamaria, Petricca, Luca, Tolusso, Barbara, Alivernini, Stefano, Di Mario, Clara, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Di Giorgio, Angela, Null, Null, Landi, Francesco (ORCID:0000-0002-3472-1389), Gremese, Elisa (ORCID:0000-0002-2248-1058), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Pagano, Francesco, Salerno, Andrea, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Cauda, Roberto (ORCID:0000-0002-1498-4229), Murri, Rita (ORCID:0000-0003-4263-7854), Cingolani, Antonella (ORCID:0000-0002-3793-2755), Ventura, Giulio (ORCID:0000-0002-0304-7264), Addolorato, Giovanni (ORCID:0000-0002-1522-9946), Zocco, Maria Assunta (ORCID:0000-0002-0814-9542), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Cattani, Paola (ORCID:0000-0003-4678-4763), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Sali, Michela (ORCID:0000-0003-3609-2990), Rizzo, Stanislao (ORCID:0000-0001-6302-063X), Savastano, Maria Cristina (ORCID:0000-0003-1397-4333), Passali, Giulio Cesare (ORCID:0000-0002-8176-0962), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Galli, Jacopo (ORCID:0000-0001-6353-6249), Settimi, Stefano (ORCID:0000-0003-0104-1501), Mele, Dario, Valentini, Piero (ORCID:0000-0001-6095-9510), Richeldi, Luca (ORCID:0000-0001-8594-1448), Corbo, Giuseppe Maria (ORCID:0000-0002-8104-4659), Licata, Maria Angela, Sani, Gabriele (ORCID:0000-0002-9767-8752), Natale, Luigi (ORCID:0000-0002-7949-5119), Larici, Anna Rita (ORCID:0000-0002-1882-6244), Marano, Riccardo (ORCID:0000-0003-2710-2093), Pirronti, Tommaso (ORCID:0000-0003-3138-4097), Tolusso, Barbara (ORCID:0000-0002-9108-6609), Alivernini, Stefano (ORCID:0000-0002-7383-4212), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), Zazzara, Maria Beatrice, Modoni, Anna, Bizzarro, Alessandra, Lauria, Alessandra, Ciciarello, Francesca, Pais, Cristina, Galluzzo, Vincenzo, Landi, Francesco, Tostato, Matteo, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Porcari, Serena, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea Maria, Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Picca, Anna, Savera, Giulia, Cauda, Roberto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, Davide, Ciccullo, Arturo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Zocco, Maria Assunta, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, Maria Grazia, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, Giovanni, Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Di Cesare, Tiziana, Guarino, Mariateresa, Corbò, Marco, Settimi, Stefano, Mele, Dario Antonio, Brigato, Francesca, Buonsenso, Danilo, Valentini, Piero, Sinatti, Dario, De Rose, Gabriella, Richeldi, Luca, Lombardi, Francesco, Calabrese, Angelo, Varone, Francesco, Leone, Paolo Maria, Siciliano, Matteo, Corbo, Giuseppe Maria, Montemurro, Giuliano, Calvello, Mariarosaria, Intini, Enrica, Simonetti, Jacopo, Pasciuto, Giuliana, Adiletta, Veronica, Sofia, Carmelo, Licata, Maria Angela Vittoria Anna Chiara, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Modica, Marco, Montanari, Silvia, Catinari, Antonello, Terenzi, Beatrice, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Pirronti, Tommaso, Infante, Amato, Paglionico, Annamaria, Petricca, Luca, Tolusso, Barbara, Alivernini, Stefano, Di Mario, Clara, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Di Giorgio, Angela, Null, Null, Landi, Francesco (ORCID:0000-0002-3472-1389), Gremese, Elisa (ORCID:0000-0002-2248-1058), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Pagano, Francesco, Salerno, Andrea, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Cauda, Roberto (ORCID:0000-0002-1498-4229), Murri, Rita (ORCID:0000-0003-4263-7854), Cingolani, Antonella (ORCID:0000-0002-3793-2755), Ventura, Giulio (ORCID:0000-0002-0304-7264), Addolorato, Giovanni (ORCID:0000-0002-1522-9946), Zocco, Maria Assunta (ORCID:0000-0002-0814-9542), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Cattani, Paola (ORCID:0000-0003-4678-4763), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Sali, Michela (ORCID:0000-0003-3609-2990), Rizzo, Stanislao (ORCID:0000-0001-6302-063X), Savastano, Maria Cristina (ORCID:0000-0003-1397-4333), Passali, Giulio Cesare (ORCID:0000-0002-8176-0962), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Galli, Jacopo (ORCID:0000-0001-6353-6249), Settimi, Stefano (ORCID:0000-0003-0104-1501), Mele, Dario, Valentini, Piero (ORCID:0000-0001-6095-9510), Richeldi, Luca (ORCID:0000-0001-8594-1448), Corbo, Giuseppe Maria (ORCID:0000-0002-8104-4659), Licata, Maria Angela, Sani, Gabriele (ORCID:0000-0002-9767-8752), Natale, Luigi (ORCID:0000-0002-7949-5119), Larici, Anna Rita (ORCID:0000-0002-1882-6244), Marano, Riccardo (ORCID:0000-0003-2710-2093), Pirronti, Tommaso (ORCID:0000-0003-3138-4097), Tolusso, Barbara (ORCID:0000-0002-9108-6609), Alivernini, Stefano (ORCID:0000-0002-7383-4212), and Santoliquido, Angelo (ORCID:0000-0003-1539-4017)

Abstract

Background Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central and peripheral nervous system manifestations. Neurological symptoms, such as headache or persistent loss of smell and taste, have also been documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment and sleep disorders appear to be frequent long term neurological manifestations after hospitalization due to COVID-19. Less is known in relation to peripheral nerve injury related to Sars-CoV-2 infection. Case presentation We report the case of a 47-year-old female presenting with a unilateral chest pain radiating to the left arm lasting for more than two months after recovery from Sars-CoV-2 infection. After referral to our post-acute outpatient service for COVID-19 long haulers, she was diagnosed with a unilateral, atypical, pure sensory brachial plexus neuritis potentially related to COVID-19, which occurred during the acute phase of a mild Sars-CoV-2 infection and persisted for months after resolution of the infection. Conclusions We presented a case of atypical Parsonage-Turner syndrome potentially triggered by Sars-CoV-2 infection, with symptoms and repercussion lasting after viral clearance. A direct involvement of the virus remains uncertain, and the physiopathology is unclear. The treatment of COVID-19 and its long-term consequences represents a relatively new challenge for clinicians and health care providers. A multidisciplinary approach to following-up COVID-19 survivors is strongly advised.

Published
2022

17. High prevalence of lower limb atherosclerosis is linked with the gut–liver axis in patients with primary biliary cholangitis.

Author

Ponziani, Francesca Romana, Nesci, Antonio, Caputo, Camilla, Salvatore, Lucia, Picca, Anna, Del Chierico, Federica, Paroni Sterbini, Francesco, Marzetti, Emanuele, Di Giorgio, Angela, Santoro, Luca, Putignani, Lorenza, Gasbarrini, Antonio, Santoliquido, Angelo, and Pompili, Maurizio

Subjects
*CHOLANGITIS, *NON-alcoholic fatty liver disease, *PERIPHERAL vascular diseases, *AMINO acid metabolism, *TIBIAL arteries, *ARTERIAL diseases
Abstract

Background and Aims: Hypercholesterolemia is frequent in people with primary biliary cholangitis (PBC); however, it does not seem to confer an increased risk of cardiovascular disease. We aimed to evaluate the prevalence of peripheral arterial disease in PBC women and its association with the gut–liver axis and systemic inflammation. Methods: Thirty patients affected by PBC and hypercholesterolemia were enrolled, with equal‐sized groups of women with non‐alcoholic fatty liver disease (NAFLD) and healthy controls (CTRL). All patients underwent Doppler ultrasound examination of peripheral arteries, assessment of flow‐mediated dilation, quantification of circulating cytokines and vasoactive mediators and characterization of the gut microbiota. Results: PBC patients had a higher prevalence of lower extremity arterial disease (LEAD) defined as atherosclerotic plaques in any of femoral, popliteal and/or tibial arteries compared with both NAFLD and CTRL women (83.3% vs. 53.3% and 50%, respectively; p =.01). Factors associated with LEAD at univariate analysis were VCAM‐1 (p =.002), ICAM‐1 (p =.003), and TNF‐alpha (p =.04) serum levels, but only VCAM‐1 (OR 1.1, 95% CI 1.0–1.1; p =.04) and TNF‐alpha (OR 1.12, 95% CI 0.99–1.26; p =.04) were confirmed as independent predictors in the multivariate model. Gut microbiota analysis revealed that Acidaminococcus (FDR = 0.0008), Bifidobacterium (FDR = 0.001) and Oscillospira (FDR = 0.03) were differentially expressed among groups. Acidaminococcus, which was increased in PBC, was positively correlated with TNF‐alpha serum levels. Down‐regulation of metabolic pathways linked to fatty acid and butyrate metabolism, glyoxylate metabolism and branched‐chain amino acids degradation was found in the functional gut metagenome of PBC women. Conclusions: LEAD is common in patients affected by PBC and is associated with inflammatory markers and alterations in the gut–liver axis. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Distinctive Role of the Systemic Inflammatory Profile in Non-Small-Cell Lung Cancer Younger and Elderly Patients Treated with a PD-1 Immune Checkpoint Blockade: A Real-World Retrospective Multi-Institutional Analysis

Author

Nardone, Valerio, primary, Giannicola, Rocco, additional, Giannarelli, Diana, additional, Saladino, Rita Emilena, additional, Azzarello, Domenico, additional, Romeo, Caterina, additional, Bianco, Giovanna, additional, Rizzo, Maria Rosaria, additional, Di Meo, Irene, additional, Nesci, Antonio, additional, Pastina, Pierpaolo, additional, Falzea, Antonia Consuelo, additional, Caracciolo, Daniele, additional, Reginelli, Alfonso, additional, Caraglia, Michele, additional, Luce, Amalia, additional, Mutti, Luciano, additional, Giordano, Antonio, additional, Cappabianca, Salvatore, additional, Pirtoli, Luigi, additional, Barbieri, Vito, additional, Tassone, Pierfrancesco, additional, Tagliaferri, Pierosandro, additional, and Correale, Pierpaolo, additional

Published
2021
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20. Depression and Endothelial Dysfunction in Psoriatic Arthritis: Is There Any Possible Relationship?

Author

De Lorenzis, Enrico, primary, Di Giorgio, Angela, additional, Natalello, Gerlando, additional, Nesci, Antonio, additional, Tanti, Giacomo, additional, Rubortone, Pietro, additional, Lucchetti, Donatella, additional, Magurano, Maria Rosaria, additional, Di Mario, Clara, additional, Tolusso, Barbara, additional, Peluso, Giusy, additional, Santoliquido, Angelo, additional, and Gremese, Elisa, additional

Published
2021
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21. Residual respiratory impairment after COVID-19 pneumonia

Author

Lombardi, Francesco, Calabrese, Angelo, Iovene, Bruno, Pierandrei, Chiara, Lerede, Marialessia, Varone, Francesco, Richeldi, Luca, Sgalla, Giacomo, Landi, Francesco, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Benvenuto, Francesca, Bramato, Giulia, Carfi', Angelo, Ciciarello, Francesca, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Carmen, Napolitano, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Anna, Picca, Giulia, Savera, Tamburrini, Enrica, Borghetti, Alberto, Simona Di Gianbenedetto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Davide, Moschese, Arturo, Ciccullo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Gertrude, Mingrone, Zocco, Maria Assunta, Mauirizio, Sanguinetti, Cattani Franchi, Paola, Marchetti, Simona, Alessandro, Bizzarro, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Maria Grazia Cozzupoli, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Giovanni Di Cintio, Ylenia, Longobardi, Laura, Tricarico, Santantonio, Mariaconsiglia, Buonsenso, Danilo, Valentini, Piero, Davide, Pata, Davide, Sinatti, De Rose, Cristina, Aangelo, Calabrese, Sani, Gabriele, Delfina, Janiri, Giulia, Giuseppin, Marzia, Molinaro, Modica, Marco, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Annamaria, Paglionico, Petricca, Luca, Laura, Gigante, Gerlando, Natalello, Fedele, Anna Laura, Lizzio, Marco Maria, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, and Valentina, Popolla

Subjects
Male, Pulmonary and Respiratory Medicine, Percent Predicted Total Lung Capacity, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, Partial Pressure, Pneumonia, Viral, Walk Test, 030204 cardiovascular system & hematology, dyspnoea, Severity of Illness Index, Pulmonary function testing, Diseases of the respiratory system, 03 medical and health sciences, PFT, 0302 clinical medicine, Percent Predicted Residual Volume, DLCO, cough, Diffusing capacity, 6MWT, Humans, Medicine, Respiratory function, Lung volumes, Aged, COVID, Carbon Monoxide, Exercise Tolerance, RC705-779, SARS-CoV-2, business.industry, Research, Settore MED/09 - MEDICINA INTERNA, COVID-19, Middle Aged, Oxygen, Residual Volume, Dyspnea, 030228 respiratory system, Respiratory failure, Anesthesia, Pulmonary Diffusing Capacity, Female, ABG, Blood Gas Analysis, business
Abstract

Introduction The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing the potential for long-term respiratory sequelae in these patients. We assessed the respiratory function in a cohort of patients after recovering from SARS-Cov-2 infection, stratified according to PaO2/FiO2 (p/F) values. Method Approximately one month after hospital discharge, 86 COVID-19 patients underwent physical examination, arterial blood gas (ABG) analysis, pulmonary function tests (PFTs), and six-minute walk test (6MWT). Patients were also asked to quantify the severity of dyspnoea and cough before, during, and after hospitalization using a visual analogic scale (VAS). Seventy-six subjects with ABG during hospitalization were stratified in three groups according to their worst p/F values: above 300 (n = 38), between 200 and 300 (n = 30) and below 200 (n = 20). Results On PFTs, lung volumes were overall preserved yet, mean percent predicted residual volume was slightly reduced (74.8 ± 18.1%). Percent predicted diffusing capacity for carbon monoxide (DLCO) was also mildly reduced (77.2 ± 16.5%). Patients reported residual breathlessness at the time of the visit (VAS 19.8, p Conclusion Approximately one month after hospital discharge, patients with COVID-19 can have residual respiratory impairment, including lower exercise tolerance. The extent of this impairment seems to correlate with the severity of respiratory failure during hospitalization.

Published
2021

22. Additional file 4 of Improved gut microbiota features after the resolution of SARS‑CoV‑2 infection

Author

De Maio, Flavio, Ianiro, Gianluca, Coppola, Gaetano, Santopaolo, Francesco, Abbate, Valeria, Bianco, Delia Mercedes, Del Zompo, Fabio, De Matteis, Giuseppe, Leo, Massimo, Nesci, Antonio, Nicoletti, Alberto, Pompili, Maurizio, Cammarota, Giovanni, Posteraro, Brunella, Sanguinetti, Maurizio, Gasbarrini, Antonio, and Ponziani, Francesca Romana

Abstract

Additional file 4. Supplementary methods.

Published
2021
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23. Additional file 1 of Improved gut microbiota features after the resolution of SARS‑CoV‑2 infection

Author

De Maio, Flavio, Ianiro, Gianluca, Coppola, Gaetano, Santopaolo, Francesco, Abbate, Valeria, Bianco, Delia Mercedes, Del Zompo, Fabio, De Matteis, Giuseppe, Leo, Massimo, Nesci, Antonio, Nicoletti, Alberto, Pompili, Maurizio, Cammarota, Giovanni, Posteraro, Brunella, Sanguinetti, Maurizio, Gasbarrini, Antonio, and Ponziani, Francesca Romana

Subjects
viruses, fungi, virus diseases, skin and connective tissue diseases, respiratory tract diseases
Abstract

Additional file 1. Principal coordinate analysis (PCoA) on weighted UniFrac distance of the gut microbiome of patient with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2)-related pneumonia, who were tested before and after resolution of the infection, and patients with SARS-CoV-2 unrelated pneumonia.

Published
2021
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24. Neutrophil-to-lymphocyte ratio but not monocyte-to-HDL cholesterol ratio nor platelet-to-lymphocyte ratio correlates with early stages of lower extremity arterial disease: An ultrasonographic study

Author

Santoro, L., Ferraro, Pietro Manuel, Nesci, Antonio, D'Alessandro, A., Macerola, Noemi, Forni, Franca, Tartaglione, R., De Vitis, Rocco, Gasbarrini, Antonio, Santoliquido, Angelo, Ferraro P. M. (ORCID:0000-0002-1379-022X), Nesci A., Macerola N., Forni F. (ORCID:0000-0002-7208-2047), De Vitis R., Gasbarrini A. (ORCID:0000-0002-7278-4823), Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro, L., Ferraro, Pietro Manuel, Nesci, Antonio, D'Alessandro, A., Macerola, Noemi, Forni, Franca, Tartaglione, R., De Vitis, Rocco, Gasbarrini, Antonio, Santoliquido, Angelo, Ferraro P. M. (ORCID:0000-0002-1379-022X), Nesci A., Macerola N., Forni F. (ORCID:0000-0002-7208-2047), De Vitis R., Gasbarrini A. (ORCID:0000-0002-7278-4823), and Santoliquido A. (ORCID:0000-0003-1539-4017)

Abstract

Objective: The role of inflammatory markers as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-high-density lipoprotein-cholesterol ratio (MHR), and platelet-to-lymphocyte ratio (PLR) in cardiovascular diseases has been widely investigated in recent years. In the context of lower extremity arterial disease (LEAD), this association has been mainly studied in the advanced stages. The aim of our study was to investigate the role of these inflammatory markers in all stages of LEAD, including early ones, using ultrasonography as diagnostic tool, together with ankle- brachial index (ABI) determination. Patients and Methods: In this cross-sectional observational study, we enrolled 240 patients undergoing ultrasonographic evaluation of the lower limb arteries and ABI determination because of symptoms suggestive of LEAD or presence of known cardiovascular risk factors. Results: In our study population, we found that ultrasonographic categories of LEAD were associated with NLR, but not with MHR and PLR. Conclusions: These results confirm that a specific pattern of inflammation can be found in all stages of LEAD, including early ones.

Published
2021

25. COVID-19 and intestinal inflammation: Role of fecal calprotectin

Author

Abbate, Valeria, Acampora, Nicola, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Antonelli, Mariangela, Antonucci, Gabriele, Anzellotti, Gian Marco, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Barone, Fabiana, Bellantone, Rocco Domenico Alfonso, Bellieni, Andrea, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Bibbò, Stefano, Bini, Alessandra, Bisanti, Alessandra, Biscetti, Federico, Bocci, Maria Grazia, Bonadia, Nicola, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Bruni, Teresa, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Burzo, Livia, Calabrese, Angelo, Calvello, Maria Rosaria, Cambieri, Andrea, Cambise, Chiara, Cammà, Giulia, Candelli, Marcello, Canistro, Gennaro, Cantanale, Antonello, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Cardone, Silvia, Carelli, Simone, Carfì, Angelo, Carnicelli, Annamaria, Caruso, Cristiano, Casciaro, Francesco Antonio, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Cesarano, Melania, Chiarito, Annalisa, Cianci, Rossella, Cicchinelli, Sara, Ciccullo, Arturo, Cicetti, Marta, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Maria Ludovica, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Costanzi, Matteo, Covino, Marcello, Crupi, Davide, Cutuli, Salvatore Lucio, D'Addio, Stefano, D'Alessandro, Alessia, D'AlfonsoD'Angelo, Maria ElenaEmanuela, D'Aversa, Francesca, Damiano, Fernando, De Berardinis, Gian Maria, De Cunzo, Tommaso, De Gaetano, Donati Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Santis, Paolo, De Siena, Martina, De Vito, Francesco, Del Gatto, Valeria, Del Giacomo, Paola, Del Zompo, Fabio, Dell'Anna, Antonio Maria, Polla, Davide Della, Di Gialleonardo, Luca, Di Giambenedetto, Simona, Di Luca, Roberta, Di Maurizio, Luca, Di Muro, Mariangela, Dusina, Alex, Eleuteri, Davide, Esperide, Alessandra, Fachechi, Daniele, Faliero, Domenico, Falsiroli, Cinzia, Fantoni, Massimo, Fedele, Annalaura, Feliciani, Daniela, Ferrante, Cristina, Ferrone, Giuliano, Festa, Rossano, Fiore, Maria Chiara, Flex, Andrea, Forte, Evelina, Franceschi, Francesco, Francesconi, Alessandra, Franza, Laura, Funaro, Barbara, Fuorlo, Mariella, Fusco, Domenico, Gabrielli, Maurizio, Gaetani, Eleonora, Galletta, Claudia, Gallo, Antonella, Gambassi, Giovanni, Garcovich, Matteo, Gasbarrini, Antonio, Gasparrini, Irene, Gelli, Silvia, Giampietro, Antonella, Gigante, Laura, Giuliano, Gabriele, Giuliano, Giorgia, Giupponi, Bianca, Gremese, Elisa, Grieco, Domenico Luca, Guerrera, Manuel, Guglielmi, Valeria, Guidone, Caterina, Gullì, Antonio, Iaconelli, Amerigo, Iafrati, Aurora, Ianiro, Gianluca, Iaquinta, Angela, Impagnatiello, Michele, Inchingolo, Riccardo, Intini, Enrica, Iorio, Raffaele, Izzi, Immacolata Maria, Jovanovic, Tamara, Kadhim, Cristina, La Macchia, Rosa, La Milia, Daniele Ignazio, Landi, Francesco, Landi, Giovanni, Landi, Rosario, Landolfi, Raffaele, Leo, Massimo, Leone, Paolo Maria, Levantesi, Laura, Liguori, Antonio, Liperoti, Rosa, Lizzio, Marco Maria, Monaco, Maria Rita Lo, Locantore, Pietro, Lombardi, Francesco, Lombardi, Gianmarco, Lopetuso, Loris, Loria, Valentina, Losito, Angela Raffaella, Lucia, Mothanje Barbara Patricia, Macagno, Francesco, Macerola, Noemi, Maggi, Giampaolo, Maiuro, Giuseppe, Mancarella, Francesco, Mangiola, Francesca, Manno, Alberto, Marchesini, Debora, Maresca, Gian Marco, Marrone, Giuseppe, Martis, Ilaria, Martone, Anna Maria, Marzetti, Emanuele, Mattana, Chiara, Matteo, Maria Valeria, Maviglia, Riccardo, Mazzarella, Ada, Memoli, Carmen, Miele, Luca, Migneco, Alessio, Mignini, Irene, Milani, Alessandro, Milardi, Domenico, Montalto, Massimo, Montemurro, Giuliano, Monti, Flavia, Montini, Luca, Morena, Tony Christian, Morra, Vincenzina, Morretta, Chiara, Moschese, Davide, Murace, Celeste Ambra, Murdolo, Martina, Murri, Rita, Napoli, Marco, Nardella, Elisabetta, Natalello, Gerlando, Natalini, Daniele, Navarra, Simone Maria, Nesci, Antonio, Nicoletti, Alberto, Nicoletti, Rocco, Nicoletti, Tommaso Filippo, Nicolò, Rebecca, Nicolotti, Nicola, Nista, Enrico Celestino, Nuzzo, Eugenia, Oggiano, Marco, Ojetti, Veronica, Pagano, Francesco Cosimo, Paiano, Gianfranco, Pais, Cristina, Pallavicini, Federico, Palombo, Andrea, Paolillo, Federico, Papa, Alfredo, Papanice, Domenico, Papparella, Luigi Giovanni, Paratore, Mattia, Parrinello, Giuseppe, Pasciuto, Giuliana, Pasculli, Pierpaolo, Pecorini, Giovanni, Perniola, Simone, Pero, Erika, Petricca, Luca, Petrucci, Martina, Picarelli, Chiara, Piccioni, Andrea, Piccolo, Annalisa, Piervincenzi, Edoardo, Pignataro, Giulia, Pignataro, Raffaele, Pintaudi, Gabriele, Pisapia, Luca, Pizzoferrato, Marco, Pizzolante, Fabrizio, Pola, Roberto, Policola, Caterina, Pompili, Maurizio, Pontecorvi, Flavia, Pontecorvi, Valerio, Ponziani, Francesca, Popolla, Valentina, Porceddu, Enrica, Porfidia, Angelo, Porro, Lucia Maria, Potenza, Annalisa, Pozzana, Francesca, Privitera, Giuseppe, Pugliese, Daniela, Pulcini, Gabriele, Racco, Simona, Raffaelli, Francesca, Ramunno, Vittoria, Rapaccini, Gian Ludovico, Richeldi, Luca, Rinninella, Emanuele, Rocchi, Sara, Romanò, Bruno, Romano, Stefano, Rosa, Federico, Rossi, Laura, Rossi, Raimondo, Rossini, Enrica, Rota, Elisabetta, Rovedi, Fabiana, Rubino, Carlotta, Rumi, Gabriele, Russo, Andrea, Sabia, Luca, Salerno, Andrea, Salini, Sara, Salvatore, Lucia, Samori, Dehara, Sandroni, Claudio, Sanguinetti, Maurizio, Santarelli, Luca, Santini, Paolo, Santolamazza, Danilo, Santoliquido, Angelo, Santopaolo, Francesco, Santoro, Michele Cosimo, Sardeo, Francesco, Sarnari, Caterina, Saviano, Angela, Saviano, Luisa, Scaldaferri, Franco, Scarascia, Roberta, Schepis, Tommaso, Schiavello, Francesca, Scoppettuolo, Giancarlo, Sedda, Davide, Sessa, Flaminio, Sestito, Luisa, Settanni, Carlo, Siciliano, Matteo, Siciliano, Valentina, Sicuranza, Rossella, Simeoni, Benedetta, Simonetti, Jacopo, Smargiassi, Andrea, Soave, Paolo Maurizio, Sonnino, Chiara, Staiti, Domenico, Stella, Claudia, Stella, Leonardo, Stival, Eleonora, Taddei, Eleonora, Talerico, Rossella, Tamburello, Elio, Tamburrini, Enrica, Tanzarella, Eloisa Sofia, Tarascio, Elena, Tarli, Claudia, Tersali, Alessandra, Tilli, Pietro, Timpano, Jacopo, Torelli, Enrico, Torrini, Flavia, Tosato, Matteo, Tosoni, Alberto, Tricoli, Luca, Tritto, Marcello, Tumbarello, Mario, Tummolo, Anita Maria, Vallecoccia, Maria Sole, Valletta, Federico, Varone, Francesco, Vassalli, Francesco, Ventura, Giulio, Verardi, Lucrezia, Vetrone, Lorenzo, Vetrugno, Giuseppe, Visconti, Elena, Visconti, Felicia, Viviani, Andrea, Zaccaria, Raffaella, Zaccone, Carmelina, Zelano, Lorenzo, Dal Verme, Lorenzo Zileri, Zuccalà, Giuseppe, and Troiani, Eliana

Published
2020
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28. Psychological Distress After Covid-19 Recovery: Reciprocal Effects With Temperament and Emotional Dysregulation. An Exploratory Study of Patients Over 60 Years of Age Assessed in a Post-acute Care Service

Author

Janiri, D., Kotzalidis, G. D., Giuseppin, G., Molinaro, M., Modica, Marco, Montanari, Silvia, Terenzi, Beatrice, Carfi, A., Landi, Francesco, Sani, Gabriele, rancesco Landi, Elisa Gremese, Roberto Bernabei, Massimo Fantoni, Gasbarrini, Antonio, Settanni, Carlo Romano, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfi', Angelo, Ciciarello, Francesca, Rita, M., Lo Monaco, Andrea, Martone, Anna Maria, Marzetti, Emanuele, Carmennapolitano, Pagano, Francesco Cosimo, Rocchi, Sara, Elisabettarota, Salerno, Andrea, Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Anna, Picca, Savera, Giulia, Cauda, Roberto, Tamburrini, Enrica, Borghetti, Alberto, Simona Di Gianbenedetto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Davide, Moschese, Arturo, Ciccullo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Bizzarro, Alessandra, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Grazia Maria Cozzupoli, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, D'Alatri, Lucia, Crudo, Fabrizio, Giovanni Di Cintio, Longobardi, Ylenia, Laura, Tricarico, Santantonio, Mariaconsiglia, Buonsenso, Danilo, Valentini, Piero, Davide, Pata, Sinatti, Dario, De Rose, Cristina, Richeldi, Luca, Lombardi, Francesco, Angelo, Calabrese, Delfina, Janiri, Giulia, Giuseppin, Marzia, Molinaro, Natale, Luigi, Annrita, Larici, Marano, Riccardo, Annamaria, Paglionico, Petricca, Luca, Laura, Gigante, Gerlando, Natalello, Fedele, Anna Laura, Lizzio, Marco Maria, Tolusso, Barbara, Alivernini, Stefano, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Valentina, Popolla, Mari, Giorgia, Marchese, Maria Raffaella, and Ausili Cefaro, Carolina

Subjects
Affective temperaments, Coronavirus disease 2019 (COVID-19), lcsh:RC435-571, media_common.quotation_subject, Exploratory research, Disease, 03 medical and health sciences, 0302 clinical medicine, psychological distress, lcsh:Psychiatry, Medicine, emotional dysregulation, Original Research, media_common, affective temperaments, Psychiatry, nasal swab, business.industry, Settore MED/30 - MALATTIE APPARATO VISIVO, aging, Settore MED/09 - MEDICINA INTERNA, Psychological distress, COVID-19, Emotional dysregulation, Mental health, nasopharyngeal swab, 030227 psychiatry, Psychiatry and Mental health, Temperament, business, 030217 neurology & neurosurgery, Clinical psychology
Abstract

To study the long-term psychological effects of Covid-19 disease, we recruited 61 patients older than 60 years of age and administered the Kessler questionnaire K10 to assess psychological distress and classify them according to mental health risk groups. Patients' affective temperaments were assessed with the 39-item form of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS-A-39) and emotional dysregulation with the Difficulties in Emotion Regulation Scale (DERS). Patients were divided in two samples according to their scores on the K10, i.e., a high likelihood of psychological distress group (N = 18) and a low likelihood of psychological distress group (N = 43). The two groups differed on their gender composition, in that more women (N = 11) were in the former and more men in the latter (N = 29) (χ2 = 4.28; p = 0.039). The high likelihood of psychological distress group scored higher on the Cyclothymic (3.39 ± 3.45 vs. 0.93 ± 1.08, p < 0.001) and the Depressive (2.28 ± 2.82 vs. 0.65 ± 1.09, p = 0.01) affective temperaments of the TEMPS and on the lack of Impulse control (12.67 ± 4.04 vs. 9.63 ± 3.14, p = 0.003) and lack of Clarity (15.00 ± 5.56 vs. 9.85 ± 4.67, p = 0.004) scales of the DERS. Our results show that having had Covid-19 may be related with high likelihood for psychological distress in advanced-age people and this may in turn be associated with impaired emotional regulation and higher scores on depressive and cyclothymic temperaments.

Published
2020

30. Assessment of neurological manifestations in hospitalized patients with COVID-19

Author

Luigetti, M., Iorio, R., Bentivoglio, A. R., Tricoli, L., Riso, V., Marotta, J., Piano, C., Primiano, G., Zileri Del Verme, L., Lo Monaco, M. R., Calabresi, P., Abbate, Valeria, Acampora, Nicola, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Antonelli, Mariangela, Antonucci, Gabriele, Anzellotti, Gian Marco, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Barone, Fabiana, Bellantone, Rocco Domenico Alfonso, Bellieni, Andrea, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Bibbò, Stefano, Bini, Alessandra, Bisanti, Alessandra, Biscetti, Federico, Bocci, Maria Grazia, Bonadia, Nicola, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Bruni, Teresa, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Burzo, Livia, Calabrese, Angelo, Calvello, Maria Rosaria, Cambieri, Andrea, Cambise, Chiara, Cammà, Giulia, Candelli, Marcello, Canistro, Gennaro, Cantanale, Antonello, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Cardone, Silvia, Carelli, Simone, Carfì, Angelo, Carnicelli, Annamaria, Caruso, Cristiano, Casciaro, Francesco Antonio, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Cesarano, Melania, Chiarito, Annalisa, Cianci, Rossella, Cicchinelli, Sara, Ciccullo, Arturo, Cicetti, Marta, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Maria Ludovica, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Costanzi, Matteo, Covino, Marcello, Crupi, Davide, Cutuli, Salvatore Lucio, DAddio, Stefano, DAlessandro, Alessia, DAlfonso, Maria Elena, DAngelo, Emanuela, DAversa, Francesca, Damiano, Fernando, De Berardinis, Gian Maria, De Cunzo, Tommaso, De Gaetano, Donati Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Santis, Paolo, De Siena, Martina, De Vito, Francesco, Del Gatto, Valeria, Del Giacomo, Paola, Del Zompo, Fabio, DellAnna, Antonio Maria, Della, Polla Davide, Di Gialleonardo, Luca, Di Giambenedetto, Simona, Di Luca, Roberta, Di Maurizio, Luca, Di Muro, Mariangela, Dusina, Alex, Eleuteri, Davide, Esperide, Alessandra, Fachechi, Daniele, Faliero, Domenico, Falsiroli, Cinzia, Fantoni, Massimo, Fedele, Annalaura, Feliciani, Daniela, Ferrante, Cristina, Ferrone, Giuliano, Festa, Rossano, Fiore, Maria Chiara, Flex, Andrea, Forte, Evelina, Franceschi, Francesco, Francesconi, Alessandra, Franza, Laura, Funaro, Barbara, Fuorlo, Mariella, Fusco, Domenico, Gabrielli, Maurizio, Gaetani, Eleonora, Galletta, Claudia, Gallo, Antonella, Gambassi, Giovanni, Garcovich, Matteo, Gasbarrini, Antonio, Gasparrini, Irene, Gelli, Silvia, Giampietro, Antonella, Gigante, Laura, Giuliano, Gabriele, Giuliano, Giorgia, Giupponi, Bianca, Gremese, Elisa, Grieco, Domenico Luca, Guerrera, Manuel, Guglielmi, Valeria, Guidone, Caterina, Gullì, Antonio, Iaconelli, Amerigo, Iafrati, Aurora, Ianiro, Gianluca, Iaquinta, Angela, Impagnatiello, Michele, Inchingolo, Riccardo, Intini, Enrica, Iorio, Raffaele, Izzi, Immacolata Maria, Jovanovic, Tamara, Kadhim, Cristina, La Macchia, Rosa, La Milia, Daniele Ignazio, Landi, Francesco, Landi, Giovanni, Landi, Rosario, Landolfi, Raffaele, Leo, Massimo, Leone, Paolo Maria, Levantesi, Laura, Liguori, Antonio, Liperoti, Rosa, Lizzio, Marco Maria, Lo Monaco Maria, Rita, Locantore, Pietro, Lombardi, Francesco, Lombardi, Gianmarco, Lopetuso, Loris, Loria, Valentina, Losito, Angela Raffaella, Lucia, Mothanje Barbara Patricia, Macagno, Francesco, Macerola, Noemi, Maggi, Giampaolo, Maiuro, Giuseppe, Mancarella, Francesco, Mangiola, Francesca, Manno, Alberto, Marchesini, Debora, Maresca, Gian Marco, Marrone, Giuseppe, Martis, Ilaria, Martone, Anna Maria, Marzetti, Emanuele, Mattana, Chiara, Matteo, Maria Valeria, Maviglia, Riccardo, Mazzarella, Ada, Memoli, Carmen, Miele, Luca, Migneco, Alessio, Mignini, Irene, Milani, Alessandro, Milardi, Domenico, Montalto, Massimo, Montemurro, Giuliano, Monti, Flavia, Montini, Luca, Morena, Tony Christian, Morra, Vincenzina, Morretta, Chiara, Moschese, Davide, Murace, Celeste Ambra, Murdolo, Martina, Murri, Rita, Napoli, Marco, Nardella, Elisabetta, Natalello, Gerlando, Natalini, Daniele, Navarra, Simone Maria, Nesci, Antonio, Nicoletti, Alberto, Nicoletti, Rocco, Nicoletti, Tommaso Filippo, Nicolò, Rebecca, Nicolotti, Nicola, Nista, Enrico Celestino, Nuzzo, Eugenia, Oggiano, Marco, Ojetti, Veronica, Pagano, Francesco Cosimo, Paiano, Gianfranco, Pais, Cristina, Pallavicini, Federico, Palombo, Andrea, Paolillo, Federico, Papa, Alfredo, Papanice, Domenico, Papparella, Luigi Giovanni, Paratore, Mattia, Parrinello, Giuseppe, Pasciuto, Giuliana, Pasculli, Pierpaolo, Pecorini, Giovanni, Perniola, Simone, Pero, Erika, Petricca, Luca, Petrucci, Martina, Picarelli, Chiara, Piccioni, Andrea, Piccolo, Annalisa, Piervincenzi, Edoardo, Pignataro, Giulia, Pignataro, Raffaele, Pintaudi, Gabriele, Pisapia, Luca, Pizzoferrato, Marco, Pizzolante, Fabrizio, Pola, Roberto, Policola, Caterina, Pompili, Maurizio, Pontecorvi, Flavia, Pontecorvi, Valerio, Ponziani, Francesca, Popolla, Valentina, Porceddu, Enrica, Porfidia, Angelo, Porro, Lucia Maria, Potenza, Annalisa, Pozzana, Francesca, Privitera, Giuseppe, Pugliese, Daniela, Pulcini, Gabriele, Racco, Simona, Raffaelli, Francesca, Ramunno, Vittoria, Rapaccini, Gian Ludovico, Richeldi, Luca, Rinninella, Emanuele, Rocchi, Sara, Romanò, Bruno, Romano, Stefano, Rosa, Federico, Rossi, Laura, Rossi, Raimondo, Rossini, Enrica, Rota, Elisabetta, Rovedi, Fabiana, Rubino, Carlotta, Rumi, Gabriele, Russo, Andrea, Sabia, Luca, Salerno, Andrea, Salini, Sara, Salvatore, Lucia, Samori, Dehara, Sandroni, Claudio, Sanguinetti, Maurizio, Santarelli, Luca, Santini, Paolo, Santolamazza, Danilo, Santoliquido, Angelo, Santopaolo, Francesco, Santoro, Michele Cosimo, Sardeo, Francesco, Sarnari, Caterina, Saviano, Angela, Saviano, Luisa, Scaldaferri, Franco, Scarascia, Roberta, Schepis, Tommaso, Schiavello, Francesca, Scoppettuolo, Giancarlo, Sedda, Davide, Sessa, Flaminio, Sestito, Luisa, Settanni, Carlo, Siciliano, Matteo, Siciliano, Valentina, Sicuranza, Rossella, Simeoni, Benedetta, Simonetti, Jacopo, Smargiassi, Andrea, Soave, Paolo Maurizio, Sonnino, Chiara, Staiti, Domenico, Stella, Claudia, Stella, Leonardo, Stival, Eleonora, Taddei, Eleonora, Talerico, Rossella, Tamburello, Elio, Tamburrini, Enrica, Tanzarella, Eloisa Sofia, Tarascio, Elena, Tarli, Claudia, Tersali, Alessandra, Tilli, Pietro, Timpano, Jacopo, Torelli, Enrico, Torrini, Flavia, Tosato, Matteo, Tosoni, Alberto, Tricoli, Luca, Tritto, Marcello, Tumbarello, Mario, Tummolo, Anita Maria, Vallecoccia, Maria Sole, Valletta, Federico, Varone, Francesco, Vassalli, Francesco, Ventura, Giulio, Verardi, Lucrezia, Vetrone, Lorenzo, Vetrugno, Giuseppe, Visconti, Elena, Visconti, Felicia, Viviani, Andrea, Zaccaria, Raffaella, Zaccone, Carmelina, Zelano, Lorenzo, Zileri Dal Verme, Lorenzo, and Zuccalà, Giuseppe

Subjects
Male, Hospitalized patients, muscle, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, neurological disorders, 0302 clinical medicine, Hyposmia, 030212 general & internal medicine, Respiratory system, education.field_of_study, Brain Diseases, Headache, virus diseases, Neuromuscular Diseases, Middle Aged, Hospitalization, medicine.anatomical_structure, Neurology, Female, medicine.symptom, Adult, medicine.medical_specialty, SARS‐CoV2, Coronavirus disease 2019 (COVID-19), Patients, Short Communication, Anosmia, precision medicine, Population, Encephalopathy, Short Communications, Clinical Neurology, Settore MED/26, 03 medical and health sciences, COVID‐19, Internal medicine, Throat, Influenza, Human, medicine, Humans, education, Aged, Retrospective Studies, business.industry, SARS-CoV-2, COVID-19, Hypoxia (medical), medicine.disease, respiratory tract diseases, body regions, Neurology (clinical), Nervous System Diseases, business, 030217 neurology & neurosurgery
Abstract

Background and purpose The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.

Published
2020

31. COVID-19 and intestinal inflammation: Role of fecal calprotectin

Author

Ojetti, Veronica, primary, Saviano, Angela, additional, Covino, Marcello, additional, Acampora, Nicola, additional, Troiani, Eliana, additional, Franceschi, Francesco, additional, Abbate, Valeria, additional, Addolorato, Giovanni, additional, Agostini, Fabiana, additional, Ainora, Maria Elena, additional, Akacha, Karim, additional, Amato, Elena, additional, Andreani, Francesca, additional, Andriollo, Gloria, additional, Annetta, Maria Giuseppina, additional, Annicchiarico, Brigida Eleonora, additional, Antonelli, Mariangela, additional, Antonucci, Gabriele, additional, Anzellotti, Gian Marco, additional, Armuzzi, Alessandro, additional, Baldi, Fabiana, additional, Barattucci, Ilaria, additional, Barillaro, Christian, additional, Barone, Fabiana, additional, Bellantone, Rocco Domenico Alfonso, additional, Bellieni, Andrea, additional, Bello, Giuseppe, additional, Benicchi, Andrea, additional, Benvenuto, Francesca, additional, Berardini, Ludovica, additional, Berloco, Filippo, additional, Bernabei, Roberto, additional, Bianchi, Antonio, additional, Biasucci, Daniele Guerino, additional, Biasucci, Luigi Marzio, additional, Bibbò, Stefano, additional, Bini, Alessandra, additional, Bisanti, Alessandra, additional, Biscetti, Federico, additional, Bocci, Maria Grazia, additional, Bonadia, Nicola, additional, Bongiovanni, Filippo, additional, Borghetti, Alberto, additional, Bosco, Giulia, additional, Bosello, Silvia, additional, Bove, Vincenzo, additional, Bramato, Giulia, additional, Brandi, Vincenzo, additional, Bruni, Teresa, additional, Bruno, Carmine, additional, Bruno, Dario, additional, Bungaro, Maria Chiara, additional, Buonomo, Alessandro, additional, Burzo, Livia, additional, Calabrese, Angelo, additional, Calvello, Maria Rosaria, additional, Cambieri, Andrea, additional, Cambise, Chiara, additional, Cammà, Giulia, additional, Candelli, Marcello, additional, Canistro, Gennaro, additional, Cantanale, Antonello, additional, Capalbo, Gennaro, additional, Capaldi, Lorenzo, additional, Capone, Emanuele, additional, Capristo, Esmeralda, additional, Carbone, Luigi, additional, Cardone, Silvia, additional, Carelli, Simone, additional, Carfì, Angelo, additional, Carnicelli, Annamaria, additional, Caruso, Cristiano, additional, Casciaro, Francesco Antonio, additional, Catalano, Lucio, additional, Cauda, Roberto, additional, Cecchini, Andrea Leonardo, additional, Cerrito, Lucia, additional, Cesarano, Melania, additional, Chiarito, Annalisa, additional, Cianci, Rossella, additional, Cicchinelli, Sara, additional, Ciccullo, Arturo, additional, Cicetti, Marta, additional, Ciciarello, Francesca, additional, Cingolani, Antonella, additional, Cipriani, Maria Camilla, additional, Consalvo, Maria Ludovica, additional, Coppola, Gaetano, additional, Corbo, Giuseppe Maria, additional, Corsello, Andrea, additional, Costante, Federico, additional, Costanzi, Matteo, additional, Crupi, Davide, additional, Cutuli, Salvatore Lucio, additional, D'Addio, Stefano, additional, D'Alessandro, Alessia, additional, D'AlfonsoD'Angelo, Maria ElenaEmanuela, additional, D'Aversa, Francesca, additional, Damiano, Fernando, additional, De Berardinis, Gian Maria, additional, De Cunzo, Tommaso, additional, De Gaetano, Donati Katleen, additional, De Luca, Giulio, additional, De Matteis, Giuseppe, additional, De Pascale, Gennaro, additional, De Santis, Paolo, additional, De Siena, Martina, additional, De Vito, Francesco, additional, Del Gatto, Valeria, additional, Del Giacomo, Paola, additional, Del Zompo, Fabio, additional, Dell'Anna, Antonio Maria, additional, Polla, Davide Della, additional, Di Gialleonardo, Luca, additional, Di Giambenedetto, Simona, additional, Di Luca, Roberta, additional, Di Maurizio, Luca, additional, Di Muro, Mariangela, additional, Dusina, Alex, additional, Eleuteri, Davide, additional, Esperide, Alessandra, additional, Fachechi, Daniele, additional, Faliero, Domenico, additional, Falsiroli, Cinzia, additional, Fantoni, Massimo, additional, Fedele, Annalaura, additional, Feliciani, Daniela, additional, Ferrante, Cristina, additional, Ferrone, Giuliano, additional, Festa, Rossano, additional, Fiore, Maria Chiara, additional, Flex, Andrea, additional, Forte, Evelina, additional, Francesconi, Alessandra, additional, Franza, Laura, additional, Funaro, Barbara, additional, Fuorlo, Mariella, additional, Fusco, Domenico, additional, Gabrielli, Maurizio, additional, Gaetani, Eleonora, additional, Galletta, Claudia, additional, Gallo, Antonella, additional, Gambassi, Giovanni, additional, Garcovich, Matteo, additional, Gasbarrini, Antonio, additional, Gasparrini, Irene, additional, Gelli, Silvia, additional, Giampietro, Antonella, additional, Gigante, Laura, additional, Giuliano, Gabriele, additional, Giuliano, Giorgia, additional, Giupponi, Bianca, additional, Gremese, Elisa, additional, Grieco, Domenico Luca, additional, Guerrera, Manuel, additional, Guglielmi, Valeria, additional, Guidone, Caterina, additional, Gullì, Antonio, additional, Iaconelli, Amerigo, additional, Iafrati, Aurora, additional, Ianiro, Gianluca, additional, Iaquinta, Angela, additional, Impagnatiello, Michele, additional, Inchingolo, Riccardo, additional, Intini, Enrica, additional, Iorio, Raffaele, additional, Izzi, Immacolata Maria, additional, Jovanovic, Tamara, additional, Kadhim, Cristina, additional, La Macchia, Rosa, additional, La Milia, Daniele Ignazio, additional, Landi, Francesco, additional, Landi, Giovanni, additional, Landi, Rosario, additional, Landolfi, Raffaele, additional, Leo, Massimo, additional, Leone, Paolo Maria, additional, Levantesi, Laura, additional, Liguori, Antonio, additional, Liperoti, Rosa, additional, Lizzio, Marco Maria, additional, Monaco, Maria Rita Lo, additional, Locantore, Pietro, additional, Lombardi, Francesco, additional, Lombardi, Gianmarco, additional, Lopetuso, Loris, additional, Loria, Valentina, additional, Losito, Angela Raffaella, additional, Lucia, Mothanje Barbara Patricia, additional, Macagno, Francesco, additional, Macerola, Noemi, additional, Maggi, Giampaolo, additional, Maiuro, Giuseppe, additional, Mancarella, Francesco, additional, Mangiola, Francesca, additional, Manno, Alberto, additional, Marchesini, Debora, additional, Maresca, Gian Marco, additional, Marrone, Giuseppe, additional, Martis, Ilaria, additional, Martone, Anna Maria, additional, Marzetti, Emanuele, additional, Mattana, Chiara, additional, Matteo, Maria Valeria, additional, Maviglia, Riccardo, additional, Mazzarella, Ada, additional, Memoli, Carmen, additional, Miele, Luca, additional, Migneco, Alessio, additional, Mignini, Irene, additional, Milani, Alessandro, additional, Milardi, Domenico, additional, Montalto, Massimo, additional, Montemurro, Giuliano, additional, Monti, Flavia, additional, Montini, Luca, additional, Morena, Tony Christian, additional, Morra, Vincenzina, additional, Morretta, Chiara, additional, Moschese, Davide, additional, Murace, Celeste Ambra, additional, Murdolo, Martina, additional, Murri, Rita, additional, Napoli, Marco, additional, Nardella, Elisabetta, additional, Natalello, Gerlando, additional, Natalini, Daniele, additional, Navarra, Simone Maria, additional, Nesci, Antonio, additional, Nicoletti, Alberto, additional, Nicoletti, Rocco, additional, Nicoletti, Tommaso Filippo, additional, Nicolò, Rebecca, additional, Nicolotti, Nicola, additional, Nista, Enrico Celestino, additional, Nuzzo, Eugenia, additional, Oggiano, Marco, additional, Ojetti, Veronica, additional, Pagano, Francesco Cosimo, additional, Paiano, Gianfranco, additional, Pais, Cristina, additional, Pallavicini, Federico, additional, Palombo, Andrea, additional, Paolillo, Federico, additional, Papa, Alfredo, additional, Papanice, Domenico, additional, Papparella, Luigi Giovanni, additional, Paratore, Mattia, additional, Parrinello, Giuseppe, additional, Pasciuto, Giuliana, additional, Pasculli, Pierpaolo, additional, Pecorini, Giovanni, additional, Perniola, Simone, additional, Pero, Erika, additional, Petricca, Luca, additional, Petrucci, Martina, additional, Picarelli, Chiara, additional, Piccioni, Andrea, additional, Piccolo, Annalisa, additional, Piervincenzi, Edoardo, additional, Pignataro, Giulia, additional, Pignataro, Raffaele, additional, Pintaudi, Gabriele, additional, Pisapia, Luca, additional, Pizzoferrato, Marco, additional, Pizzolante, Fabrizio, additional, Pola, Roberto, additional, Policola, Caterina, additional, Pompili, Maurizio, additional, Pontecorvi, Flavia, additional, Pontecorvi, Valerio, additional, Ponziani, Francesca, additional, Popolla, Valentina, additional, Porceddu, Enrica, additional, Porfidia, Angelo, additional, Porro, Lucia Maria, additional, Potenza, Annalisa, additional, Pozzana, Francesca, additional, Privitera, Giuseppe, additional, Pugliese, Daniela, additional, Pulcini, Gabriele, additional, Racco, Simona, additional, Raffaelli, Francesca, additional, Ramunno, Vittoria, additional, Rapaccini, Gian Ludovico, additional, Richeldi, Luca, additional, Rinninella, Emanuele, additional, Rocchi, Sara, additional, Romanò, Bruno, additional, Romano, Stefano, additional, Rosa, Federico, additional, Rossi, Laura, additional, Rossi, Raimondo, additional, Rossini, Enrica, additional, Rota, Elisabetta, additional, Rovedi, Fabiana, additional, Rubino, Carlotta, additional, Rumi, Gabriele, additional, Russo, Andrea, additional, Sabia, Luca, additional, Salerno, Andrea, additional, Salini, Sara, additional, Salvatore, Lucia, additional, Samori, Dehara, additional, Sandroni, Claudio, additional, Sanguinetti, Maurizio, additional, Santarelli, Luca, additional, Santini, Paolo, additional, Santolamazza, Danilo, additional, Santoliquido, Angelo, additional, Santopaolo, Francesco, additional, Santoro, Michele Cosimo, additional, Sardeo, Francesco, additional, Sarnari, Caterina, additional, Saviano, Luisa, additional, Scaldaferri, Franco, additional, Scarascia, Roberta, additional, Schepis, Tommaso, additional, Schiavello, Francesca, additional, Scoppettuolo, Giancarlo, additional, Sedda, Davide, additional, Sessa, Flaminio, additional, Sestito, Luisa, additional, Settanni, Carlo, additional, Siciliano, Matteo, additional, Siciliano, Valentina, additional, Sicuranza, Rossella, additional, Simeoni, Benedetta, additional, Simonetti, Jacopo, additional, Smargiassi, Andrea, additional, Soave, Paolo Maurizio, additional, Sonnino, Chiara, additional, Staiti, Domenico, additional, Stella, Claudia, additional, Stella, Leonardo, additional, Stival, Eleonora, additional, Taddei, Eleonora, additional, Talerico, Rossella, additional, Tamburello, Elio, additional, Tamburrini, Enrica, additional, Tanzarella, Eloisa Sofia, additional, Tarascio, Elena, additional, Tarli, Claudia, additional, Tersali, Alessandra, additional, Tilli, Pietro, additional, Timpano, Jacopo, additional, Torelli, Enrico, additional, Torrini, Flavia, additional, Tosato, Matteo, additional, Tosoni, Alberto, additional, Tricoli, Luca, additional, Tritto, Marcello, additional, Tumbarello, Mario, additional, Tummolo, Anita Maria, additional, Vallecoccia, Maria Sole, additional, Valletta, Federico, additional, Varone, Francesco, additional, Vassalli, Francesco, additional, Ventura, Giulio, additional, Verardi, Lucrezia, additional, Vetrone, Lorenzo, additional, Vetrugno, Giuseppe, additional, Visconti, Elena, additional, Visconti, Felicia, additional, Viviani, Andrea, additional, Zaccaria, Raffaella, additional, Zaccone, Carmelina, additional, Zelano, Lorenzo, additional, Dal Verme, Lorenzo Zileri, additional, and Zuccalà, Giuseppe, additional

Published
2020
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33. Evaluation of long term survival in pretreated metastatic colorectal cancer patients undergoing GOLFIG chemoimmunotherapy regimen.

Author

Correale, Pierpaolo, primary, Giannicola, Rocco, additional, Staropoli, NIcoletta, additional, Ciliberto, Domenico, additional, Azzarello, Domenico, additional, Tripepi, Giovanni, additional, Agostino, Rita Maria, additional, Strangio, Alessandra, additional, Altomonte, Maria, additional, Nesci, Antonio, additional, Francini, Guido, additional, Pastina, Pierpaolo, additional, Tassone, Pierfrancesco, additional, Pirtoli, Luigi, additional, Caporlingua, Nadia, additional, Falzea, Antonia Consuelo, additional, and Tagliaferri, Pierosandro, additional

Published
2019
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34. Effects of a New Combination of Medical Food on Endothelial Function and Lipid Profile in Dyslipidemic Subjects: A Pilot Randomized Trial

Author

Landi, Francesco, primary, Martone, Anna Maria, additional, Salini, Sara, additional, Zazzara, Beatrice, additional, Calvani, Riccardo, additional, Marzetti, Emanuele, additional, Nesci, Antonio, additional, Di Giorgio, Angela, additional, Giupponi, Bianca, additional, Santoro, Luca, additional, and Santoliquido, Angelo, additional

Published
2019
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35. Exercise and Protein Intake: A Synergistic Approach against Sarcopenia

Author

Martone, Anna Maria, Marzetti, Emanuele, Calvani, Riccardo, Picca, Anna, Tosato, Matteo, Santoro, Luca, Di Giorgio, Angela, Nesci, Antonio, Sisto, Alex, Santoliquido, Angelo, and Landi, Francesco

Subjects
Article Subject, human activities
Abstract

Sarcopenia, the age-dependent loss of muscle mass and function/strength, is increasingly recognized as a major risk factor for adverse outcomes in frail older people. As such, the skeletal muscle is a relevant target for interventions aimed at preventing or postponing the occurrence of negative health-related events in late life. The association among physical inactivity, insufficient intake of energy and protein, and poor muscle health in older adults suggests that physical exercise and targeted nutritional supplementation may offer substantial therapeutic gain against sarcopenia and its negative correlates. This view is supported by observational studies as well as by small-scale clinical trials. In this review, we summarize the available evidence on the beneficial effects of behavioral interventions on sarcopenia. We also briefly describe how the knowledge gathered so far has been used to design the “Sarcopenia and Physical fRailty IN older people: multicomponenT Treatment strategies” (SPRINTT) project. The randomized clinical trial conducted within SPRINTT will provide robust evidence on the effectiveness of exercise and nutrition at preventing negative outcomes associated with sarcopenia and physical frailty.

Published
2017
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36. Liver involvement is not associated with mortality: results from a large cohort of SARS‐CoV‐2‐positive patients.

Author

Ponziani, Francesca Romana, Del Zompo, Fabio, Nesci, Antonio, Santopaolo, Francesco, Ianiro, Gianluca, Pompili, Maurizio, and Gasbarrini, Antonio

Subjects
ALANINE aminotransferase, ASPARTATE aminotransferase, ADULT respiratory distress syndrome, LIVER, INTENSIVE care units
Abstract

Summary: Background: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is frequently associated with liver test abnormalities. Aims: To describe the evolution of liver involvement during SARS‐CoV‐2 infection and its effect on clinical course and mortality. Methods: Data of 515 SARS‐CoV‐2‐positive patients were collected at baseline and during follow‐up, last evaluation or death. Stratification based on need for hospitalisation, severe disease and admission to intensive care unit (ICU) was performed. The association between liver test abnormalities (baseline and peak values) and ICU admission or death was also explored. Results: Liver test abnormalities were found in 161 (31.3%) patients. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) were increased in 20.4%, 19% and 13.6% of patients, respectively. Baseline liver test abnormalities were associated with increased risk of ICU admission (OR 2.19 [95% CI 1.24‐3.89], P = 0.007) but not with mortality (OR 0.84 [95% CI 0.49‐1.41], P = 0.51). Alkaline phosphatase (ALP) peak values were correlated with risk of death (OR 1.007 [95% CI 1.002‐1.01], P = 0.005) along with age, multiple comorbidities, acute respiratory distress syndrome, ICU admission and C‐reactive protein. Alterations of liver tests worsened within 15 days of hospitalisation; however, in patients with the longest median follow‐up, the prevalence of liver test alterations decreased over time, returning to around baseline levels. Conclusions: In SARS‐CoV‐2‐positive patients without pre‐existing severe chronic liver disease, baseline liver test abnormalities are associated with the risk of ICU admission and tend to normalise over time. The ALP peak value may be predictive of a worse prognosis. [ABSTRACT FROM AUTHOR]

Published
2020
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38. New semiquantitative ultrasonographic score for peripheral arterial disease assessment and its association with cardiovascular risk factors

Author

Santoro, Luca, Ferraro, Pietro Manuel, Flex, Andrea, Nesci, Antonio, De Matteis, Giuseppe, Di Giorgio, Angela, Zaccone, Vincenzo, Gambaro, Giovanni, Gasbarrini, Antonio, Santoliquido, Angelo, Ferraro, Pietro Manuel (ORCID:0000-0002-1379-022X), Flex, Andrea (ORCID:0000-0003-2664-4165), Gambaro, Giovanni (ORCID:0000-0001-5733-2370), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), Santoro, Luca, Ferraro, Pietro Manuel, Flex, Andrea, Nesci, Antonio, De Matteis, Giuseppe, Di Giorgio, Angela, Zaccone, Vincenzo, Gambaro, Giovanni, Gasbarrini, Antonio, Santoliquido, Angelo, Ferraro, Pietro Manuel (ORCID:0000-0002-1379-022X), Flex, Andrea (ORCID:0000-0003-2664-4165), Gambaro, Giovanni (ORCID:0000-0001-5733-2370), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Santoliquido, Angelo (ORCID:0000-0003-1539-4017)

Abstract

The data concerning the distribution, extent and progression of peripheral arterial disease (PAD), as well as its association with traditional cardiovascular (CV) risk factors, have generally been obtained from studies of patients in advanced stages of the disease undergoing surgical or endovascular treatment. In this study, we have introduced a new semiquantitative ultrasonographic score (ultrasonographic lower limb atherosclerosis (ULLA) score) that is able to categorize lower limb atherosclerotic lesions at all stages of PAD. We then associated these ultrasonographic categories with a CV risk profile. We enrolled 320 consecutive subjects with symptoms suggestive of PAD or with known CV risk factors referring to our angiology unit between 1 July 2014 and 30 June 2015 for ultrasonographic evaluation of the lower limb arteries. Femoropopliteal and run-off segments were categorized together and separately based on their ultrasonographic characteristics. In univariate and multivariate analyses, the ULLA scores were significantly associated with the main CV risk factors, that is, age, male gender, cigarette smoking, arterial hypertension, diabetes, dyslipidemia, sedentary lifestyle, previous CV events and family history of CV disease, and also confirming the specific association of single risk factors with different segments of lower limb arteries. The proposed ULLA score enables a complete evaluation of the entire lower limb atherosclerotic burden, extending the results concerning the association of PAD with CV risk factors to all stages of the disease, including the early stages. It can be feasible that this new score will facilitate better evaluation of the progression of PAD and its prospective role in CV risk stratification.

Published
2016

39. New semiquantitative ultrasonographic score for peripheral arterial disease assessment and its association with cardiovascular risk factors

Author

Santoro, Luca, primary, Ferraro, Pietro Manuel, additional, Flex, Andrea, additional, Nesci, Antonio, additional, De Matteis, Giuseppe, additional, Di Giorgio, Angela, additional, Zaccone, Vincenzo, additional, Gambaro, Giovanni, additional, Gasbarrini, Antonio, additional, and Santoliquido, Angelo, additional

Published
2016
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40. New modalities of ultrasound-based intima-media thickness, arterial stiffness and non-coronary vascular calcifications detection to assess cardiovascular risk

Author

FLORE, ROBERTO ANTONIO, PONZIANI, FRANCESCA ROMANA, TINELLI, GIOVANNI, ARENA, VINCENZO, FONNESU, CLAUDIA, NESCI, ANTONIO, SANTORO, LUCA, TONDI, PAOLO, SANTOLIQUIDO, ANGELO, FLORE, ROBERTO ANTONIO, PONZIANI, FRANCESCA ROMANA, TINELLI, GIOVANNI, ARENA, VINCENZO, FONNESU, CLAUDIA, NESCI, ANTONIO, SANTORO, LUCA, TONDI, PAOLO, and SANTOLIQUIDO, ANGELO

Published
2015

41. Biomarkers of low-grade inflammation in primary varicose veins of the lower limbs

Author

FLORE, ROBERTO ANTONIO, PONZIANI, FRANCESCA ROMANA, GERARDINO, LAURA, SANTOLIQUIDO, ANGELO, DI GIORGIO, ANGELA, LUPASCU, ANDREA, NESCI, ANTONIO, TONDI, PAOLO, FLORE, ROBERTO ANTONIO, PONZIANI, FRANCESCA ROMANA, GERARDINO, LAURA, SANTOLIQUIDO, ANGELO, DI GIORGIO, ANGELA, LUPASCU, ANDREA, NESCI, ANTONIO, and TONDI, PAOLO

Published
2015

42. Acute alcohol intoxication

Author

Vonghia, Luisa, Leggio, Lorenzo, Ferrulli, Anna, Bertini, Marco, Gasbarrini, Giovanni, Addolorato, Giovanni, Alcoholism Treatment Study Group, Abenavoli, Ludovico, D'Angelo, Cristina, Cardone, Silvia, Mirijello, Antonio, Leso, Veruska, Piano, Salvatore, Nesci, Antonio, Capristo, Esmeralda, Malandrino, Noemi, Caputo, Fabio, Francini, Sara, Stoppo, Michela, Vignoli, Teo, Bernardi, Mauro, Vonghia L, Leggio L, Ferrulli A, Bertini M, Gasbarrini G, Addolorato G, Alcoholism Treatment Study Group: Abenavoli L, D'Angelo C, Cardone S, Mirijello A, Leso V, Piano S, Nesci A, Capristo E, Malandrino N, Caputo F, Francini S, Stoppo M, Vignoli T, and Bernardi M.

Subjects
Emergency Medical Services, Alcohol, ACUTE ALCOHOL INTOXICATION, Acute alcohol intoxication, Alcohol-induced disorders, Emergency care, Metadoxine, Acute Disease, Alcohol Deterrents, Alcoholic Intoxication, Ataxia, Coma, Diagnosis, Differential, Drug Combinations, Ethanol, Evidence-Based Medicine, Fluid Therapy, Gait, Humans, Impulsive Behavior, Memory Disorders, Mood Disorders, Pyridoxine, Pyrrolidonecarboxylic Acid, Randomized Controlled Trials as Topic, Stupor, Treatment Outcome, Internal Medicine, NO, chemistry.chemical_compound, Alcohol and health, Diagnosis, Medicine, ALCOHOL-INDUCED DISORDERS, business.industry, METADOXINE, Emergency department, medicine.disease, Mood disorders, chemistry, Anesthesia, Differential, medicine.symptom, business, EMERGENCY CARE, medicine.drug
Abstract

Acute alcohol intoxication is a clinically harmful condition that usually follows the ingestion of a large amount of alcohol. Clinical manifestations are heterogeneous and involve different organs and apparatuses, with behavioral, cardiac, gastrointestinal, pulmonary, neurological, and metabolic effects. The management of an intoxicated patient occurs mainly in the emergency department and is aimed at stabilizing the clinical condition of the patient, depending on his/her clinical presentation. One specific drug that is useful in the treatment of acute alcohol intoxication is metadoxine, which is able to accelerate ethanol excretion. In patients presenting an acute alcohol intoxication, alcohol-related disorders should be detected so that the patient can be directed to an alcohol treatment unit, where a personalized, specific treatment can be established.

Published
2008

43. Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving

Author

Leggio, Lorenzo, primary, Ferrulli, Anna, additional, Cardone, Silvia, additional, Nesci, Antonio, additional, Miceli, Antonio, additional, Malandrino, Noemi, additional, Capristo, Esmeralda, additional, Canestrelli, Benedetta, additional, Monteleone, Palmiero, additional, Kenna, George A., additional, Swift, Robert M., additional, and Addolorato, Giovanni, additional

Published
2011
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44. Affective and Psychiatric Disorders in Celiac Disease

Author

Addolorato, Giovanni, primary, Leggio, Lorenzo, additional, D’Angelo, Cristina, additional, Mirijello, Antonio, additional, Ferrulli, Anna, additional, Cardone, Silvia, additional, Vonghia, Luisa, additional, Abenavoli, Ludovico, additional, Leso, Veruscka, additional, Nesci, Antonio, additional, Piano, Salvatore, additional, Capristo, Esmeralda, additional, and Gasbarrini, Giovanni, additional

Published
2008
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45. Affective and psychiatric disorders in celiac disease

Author

Giovanni Addolorato, Lorenzo Leggio, Cristina D'Angelo, Salvatore Piano, Veruscka Leso, Silvia Cardone, Antonio Mirijello, Esmeralda Capristo, L. Vonghia, Anna Ferrulli, Ludovico Abenavoli, Giovanni Gasbarrini, Antonio Nesci, Addolorato, Giovanni, Leggio, Lorenzo, D'Angelo, Cristina, Mirijello, Antonio, Ferrulli, Anna, Cardone, Silvia, Vonghia, Luisa, Abenavoli, Ludovico, Leso, Veruscka, Nesci, Antonio, Piano, Salvatore, Capristo, Esmeralda, and Gasbarrini, Giovanni

Subjects
Quality of life, medicine.medical_specialty, Disease, Organic disease, Affective disorders, Celiac disease, Gluten-free diet, Psychiatric disorders, Psychological support, Celiac Disease, Humans, Mental Disorders, Gastroenterology, Affective disorder, Epidemiology of child psychiatric disorders, medicine, In patient, Psychiatry, business.industry, Psychiatric disorder, General Medicine, Mental Disorder, business, Human
Abstract

Several extraintestinal clinical manifestations have been reported in celiac disease (CD). Among them, growing evidence suggests the association between CD and affective and psychiatric disorders. In this review the most frequent affective and psychiatric disorders associated with CD and the possible mechanisms involved in these associations were analyzed. The available data suggest that screening for CD in patients with affective and/or psychiatric symptoms may be useful since these disorders could be the expression of an organic disease rather than primary psychiatric illnesses.

Published
2008

46. Radial Peripapillary Capillary Plexus Perfusion and Endothelial Dysfunction in Early Post-SARS-CoV-2 Infection.

Author

Savastano MC, Santoro L, Crincoli E, Fossataro C, Gambini G, Savastano A, De Vico U, Santoliquido A, Nesci A, Landi F, Rizzo S, and On Behalf Of Gemelli Against Covid-Post-Acute Care Study Group

Abstract

Background: Endothelial cells damage and thromboinflammation are considered key elements in the generation of organ impairment in patients with COVID-19 disease. The endothelial function is evaluated by measuring flow-mediated dilation (FMD). We aimed to analyze the association between FMD impairment and retinal vascular parameters in early post-COVID-19 patients. 00118-00199Tomography (OCT), OCT Angiography (OCTA) and slit lamp examination were performed. FMD ≤ 7% was considered as pathological. Our primary outcome was to assess potential differences in the radial peripapillary capillary plexus flow index (RPCP-FI) and RPCP density (RPCP-D) values between post-COVID-19 patients with and without FMD impairment. The associations of other retinal vascular parameters with FMD impairment were assessed as secondary endpoints., Results: FMD impairment was detected in 31 patients (37.8%). RPCP-FI ( p = 0.047), age ( p = 0.048) and prevalence of diabetes ( p = 0.046) significantly differed in patients with FMD ≤ 7% in regression analysis. RPCP-FI was linearly correlated with FMD values (R = 0.244, p =0.027). SCT was found to be lower in patients with impaired FMD ( p = 0.004), although this difference was only a trend in binary logistic regression output ( p = 0.07)., Conclusions: Early post-COVID-19 patients showed a higher prevalence of FMD impairment compared to the general population. Age, diabetes and RPCP-FI were independently correlated with the presence of endothelial impairment in the early post-infective period.

Published
2022
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47. Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study.

Author

Santoro L, Falsetti L, Zaccone V, Nesci A, Tosato M, Giupponi B, Savastano MC, Moroncini G, Gasbarrini A, Landi F, Santoliquido A, and On Behalf Of Gemelli Against Covid-Post-Acute Care Study Group

Abstract

Background: Endothelial dysfunction has a role in acute COVID-19, contributing to systemic inflammatory syndrome, acute respiratory distress syndrome, and vascular events. Evidence regarding COVID-19 middle- and long-term consequences on endothelium are still lacking. Our study aimed to evaluate if COVID-19 severity could significantly affect the endothelial function after three months from the acute phase. Methods: We assessed endothelial function in outpatients with previous COVID-19 three months after negative SARS-CoV-2 molecular test by measuring flow-mediated dilation (FMD) in patients categorized according to a four-variable COVID-19 severity scale (“home care”; “hospital, no oxygen”; “hospital, oxygen”; “hospital requiring high-flow nasal canula, non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation”). FMD difference among COVID-19 severity categories was assessed with analysis of variance; we further clarified the relationship between FMD and previous COVID-19 severity with multivariate logistic models. Results: Among 658 consecutive COVID-19 subjects, we observed a significant linear trend of FMD reduction with the increase of the COVID-19 category (p < 0.0001). The presence of endothelial dysfunction was more frequent among hospitalized patients (78.3%) with respect to home-care patients (21.7%; p < 0.0001). COVID-19 severity was associated with increased endothelial dysfunction risk (OR: 1.354; 95% CI: 1.06−1.71; p = 0.011) at multivariate binary logistic analysis. FMD showed a significant direct correlation with PaO2 (p = 0.004), P/F ratio (p = 0.004), FEV1 (p = 0.008), and 6MWT (p = 0.0001). Conclusions: Hospitalized COVID-19 subjects showed an impaired endothelial function three months after the acute phase that correlated with pulmonary function impairment. Further studies are needed to evaluate if these subjects are at higher risk of developing pulmonary disease or future cardiovascular events.

Published
2022
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