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1. RNA interference is essential to modulating the pathogenesis of mosquito-borne viruses in the yellow fever mosquito Aedes aegypti

Author

Glady Hazitha Samuel, Tyler Pohlenz, Yuemei Dong, Nese Coskun, Zach N. Adelman, George Dimopoulos, and Kevin M. Myles

Subjects
Multidisciplinary
Abstract

While it has long been known that the transmission of mosquito-borne viruses depends on the establishment of persistent and nonlethal infections in the invertebrate host, specific roles for the insects’ antiviral immune pathways in modulating the pathogenesis of viral infections is the subject of speculation and debate. Here, we show that a loss-of-function mutation in the Aedes aegypti Dicer-2 ( Dcr-2 ) gene renders the insect acutely susceptible to a disease phenotype upon infection with pathogens in multiple virus families associated with important human diseases. Additional interrogation of the disease phenotype demonstrated that the virus-induced pathology is controlled through a canonical RNA interference (RNAi) pathway, which functions as a resistance mechanism. These results suggest comparatively modest contributions of proposed tolerance mechanisms to the fitness of A. aegypti infected with these pathogens. Similarly, the production of virus-derived piwi-interacting RNAs (vpiRNAs) was not sufficient to prevent the pathology associated with viral infections in Dcr-2 null mutants, also suggesting a less critical, or potentially secondary, role for vpiRNAs in antiviral immunity. These findings have important implications for understanding the ecological and evolutionary interactions occurring between A. aegypti and the pathogens they transmit to human and animal hosts.

Published
2023

2. The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)

Author

Feyza Hatice Sevgen, Dilşad Foto Özdemir, Savaş Yılmaz, Tuğba Yüksel, Dilşat Miniksar Yıldız, Funda Suleyman, Cihat Kaan Gürkan, Seda Erbilgin, Seyhan Temtek, Gonca Çelik, Berna Polat, Vahdet Gormez, Kevser Nalbant, Serkan Suren, Fatih Ozbek, Ömer Kocael, Murat Yüce, Kemal Utku Yazici, Ayşe Rodopman Arman, Dursun Karaman, Havvana Horozcu, Ayse Kilincaslan, Funda Donder, Ebru Sekmen, Ozlem Hekim Bozkurt, Guilherme V. Polanczyk, Merve Günay Ay, Mehmet Tekden, Hatice Altun, Deniz Yuce, Adem Gunes, Öznur Bilaç, Mahmut Almaidan, Ender Atabay, Yunus Emre Dönmez, Mehmet Cansiz, Hilal Tugba Kilic, Zehra Topal, Veysi Çeri, Ezgi Eynalli Gok, Oguz Sevince, Taciser Uysal, Nurcan Eren Simsek, Veli Yıldırım, Sumeyra Firat, Merve Arici Canli, Neşe Perdahlı Fiş, Kıvanç Kudret Berberoğlu, Mustafa Yasin Irmak, Yaşar Tanir, Beril Taskin, Zejnep Lushi-Şan, Mehmet Karadag, Serhat Nasıroğlu, Selçuk Özkan, Yasemin Cakan, S. Yilmaz, Özlem Özcan, Esen Yıldırım Demirdöğen, Işık Görker, Tugba Eseroglu, Burak Onur Dursun, Hasan Bayar, Gulay Gunay, Necati Uzun, Çağatay Uğur, Mücahit Öztürk, Yasemin Yulaf, Hilal Aydemir, Emine Demirbaş Çakır, Evrim Aktepe, Ümit Tural, Hatice Aksu, Gulen Guler, Bilge Merve Kalaycı, Özden Şükran Üneri, Sabri Hergüner, Esra Yildirim Ozyurt, Mehmet Fatih Kınık, Gokcen Guven, Gülseda Ayranci, Pelin Çon Bayhan, Umut Karaaslan, Nese Coskun, Selma Tural Hesapçıoğlu, Hüseyin Aktaş, Ali Evren Tufan, Salih Gençoğlan, Fatma Akkus Ozdemir, Nursu Çakin Memik, Devrim Akdemir, Özlem Kahraman, Neslihan Gokce Yazgili, Halit Necmi Uçar, Betul Gul Alic, Esra Bulanik Koc, Nese Dikmeer Bektas, Ayşe Irmak, Rümeysa Alaca, Filiz Uçar, Elif Gokce Ersoy, Basak Ayik, Özlem Bayram, Gülser Şenses Dinç, Betül Mazlum, Nilufer Okumus, Nuran Demir, Aysegul Efe, Nilfer Şahin, Eyüp Sabri Ercan, Semih Erden, Şafak Eray, Şermin Yalın Sapmaz, Zafer Güleş, Ümit Işık, Cem Gokcen, Aysegul Yolga Tahiroglu, Cihan Aslan, Burak Açıkel, Recep Bostan, Fevziye Toros, Sevcan Karakoç Demirkaya, Bedia Ince Tasdelen, Duygu Kinay, Seyda Celik Goksoy, Cansın Ceylan, Ipek Percinel Yazici, Seyma Coskun, Özlem Yıldız Gündoğdu, Murat Coskun, Zehra Babadağı, Gul Karacetin, Pınar Uran, Birim Günay Kiliç, Fatma Pinar Ari, Tuba Mutluer, Fatih Ünal, Senem Başgül, Nazike Yildiz, Hatice Polat, Börte Gürbüz Özgür, Melike Topal, Rahime Kadir Mutlu, Ibrahim Demir, Ulker Shamkhalova, Ulku Akyol Ardic, Ibrahim Durukan, Zeynep Vatansever, Hanife Ozdemir, Tuğba Türk, Busra Dogan, Hayati Sınır, Nagehan Üçok Demir, Mehmet Sertçelik, Tulin Fidan, Fethiye Kilicaslan, Pinar Vural, Didem Behice Öztop, Duygu Uygun, Serkan Güneş, Hasan Kandemir, Ayhan Bilgiç, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Şahin, Nilfer, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü., Vural, Pınar, Ege Üniversitesi, Çukurova Üniversitesi, and Ondokuz Mayıs Üniversitesi

Subjects
Male, Parents, Separation anxiety, Turkey, Phobia, Epidemiology, Randomization, Feces incontinence, Turkey (republic), Conduct disorder, Random Allocation, 0302 clinical medicine, Generalized anxiety disorder, Child parent relation, Progeny, Turkey (bird), Adjustment disorder, Prevalence, Medicine, Major depression, Psychology, Child, Selective mutism, Psychiatry, education.field_of_study, Educational status, Psychopathology, Elementary student, Posttraumatic stress disorder, Psychological rating scale, Multicenter study, Speech sound disorder, Diagnostic and Statistical Manual of Mental Disorders, Clinical trial, Psychiatry and Mental health, Mental deficiency, Anxiety disorder, Learning disorder, Social aspect, Schedule for Affective Disorders and Schizophrenia, Female, Attention deficit disorder, Nocturnal enuresis, Student, Human, Adult, medicine.medical_specialty, Acute stress disorder, Pervasive developmental disorder not otherwise specified, Adolescent, Child psychopathology, Population, Major clinical study, Mental patient, Mental, Article, Oppositional defiant disorder, 03 medical and health sciences, DSM-IV, Humans, education, Students, Cross-sectional study, Demography, Tic, business.industry, Sample size, Teacher, Likert scale, Mental disease, Childhood, Panic, 030227 psychiatry, Cross-Sectional Studies, Strengths And Difficulties Questionnaire, Problem Behavior, Hyperactivity, Obsessive compulsive disorder, Neurodevelopmental Disorders, Parent, Dysthymia, Psychiatric, a cross-sectional multicenter nationwide study (EPICPAT-T)-, NORDIC JOURNAL OF PSYCHIATRY, 2019 [ERCAN E. S. , Polanczyk G., Ardic U. A. , YÜCE D., Karacetin G., Tufan A. E. , Tural U., Aksu H., AKTEPE E., Arman A. R. , et al., -The prevalence of childhood psychopathology in Turkey], business, Social phobia, Controlled study, 030217 neurology & neurosurgery, DSM-IV Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents
Abstract

EgeUn###, Aim: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey. Method: A nation-wide, randomly selected, representative population of 5830 children (6-13 years-old) enrolled as a 2nd,3rd or 4th grade student in 30 cities were evaluated for presence of a psychiatric or mental disorder by a Sociodemographic Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and DSM-IV-Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents scales. Impairment criterion was assessed via a 3 point-Likert scale by the parent and the teacher independently. Results: Overall prevalence of any psychopathology was 37.6% without impairment criterion, and 17.1% with impairment criterion. Attention-deficit hyperactivity disorder was the most frequent diagnosis, followed by anxiety (19.5% and 16.7% without impairment, 12.4% and 5.3% with impairment, respectively). Lower education level and presence of a physical or psychiatric problem of the parents were independent predictors of any psychopathology of the offspring. Conclusion: This is the largest and most comprehensive epidemiological study to determine the prevalence of psychopathologies in children and adolescents in Turkey. Our results partly higher than, and partly comparable to previous national and international studies. It also contributes to the literature by determining the independent predictors of psychopathologies in this age group.

Published
2019

3. Prevalence of Childhood Affective disorders in Turkey: An epidemiological study

Author

Berna Polat, Hanife Ozdemir, Ender Atabay, Tuğba Türk, A. Bilgic, Yunus Emre Dönmez, Mehmet Sertçelik, Halit Necmi Uçar, Merve Arici Canli, Ümit Tural, Nurcan Eren Simsek, Hasan Bayar, Tulin Fidan, Fethiye Kilicaslan, Sevgi Özmen, Yasemin Cakan, Kemal Utku Yazici, Işık Görker, Dilşad Foto Özdemir, Rümeysa Alaca, Filiz Uçar, Esen Yıldırım Demirdöğen, Vahdet Gormez, S. Yilmaz, Ümit Işık, Seda Erbilgin, Seyhan Temtek, Kevser Nalbant, Zeynep Vatansever, Pinar Vural, Mücahit Öztürk, Ibrahim Demir, Hilal Aydemir, Havvana Horozcu, Emel Sarı Gökten, Nese Dikmeer Bektas, Nilfer Şahin, Tuğba Yüksel, Cem Gokcen, Aysegul Yolga Tahiroglu, Cihan Aslan, Ozlem Hekim Bozkurt, Hilal Tugba Kilic, Zehra Topal, Onur Burak Dursun, Busra Dogan, Esra Yildirim Ozyurt, Didem Behice Öztop, Feyza Hatice Sevgen, Fatih Ozbek, Pelin Çon Bayhan, Pınar Uran, Umut Karaaslan, Ezgi Eynalli Gok, Oguz Sevince, Veli Yıldırım, Dursun Karaman, Merve Günay Ay, Özden Şükran Üneri, Serhat Nasıroğlu, Mahmoud Almbaidheen, Eyüp Sabri Ercan, Neslihan Gokce Yazgili, Hayati Sınır, Nagehan Üçok Demir, Fatma Pinar Ari, Selma Tural Hesapçıoğlu, Birim Günay Kiliç, Gulen Guler, Esra Bulanik Koc, Funda Donder, Duygu Uygun, Serkan Güneş, Hasan Kandemir, Hatice Altun, Duygu Kinay, Cansın Ceylan, Selcuk Ozkan, Esra Demirci, Öznur Bilaç, Ipek Percinel Yazici, Seyma Coskun, Adem Gunes, Recep Bostan, Fevziye Toros, Neşe Perdahlı Fiş, Özlem Yıldız Gündoğdu, Gul Karacetin, Bedia Ince Tasdelen, Ömer Kocael, Ayşe Rodopman Arman, Mehmet Karadag, Şafak Eray, Ulker Shamkhalova, Ulku Akyol Ardic, Bilge Merve Kalaycı, Hatice Polat, Zejnep Lushi Şan, Tugba Eseroglu, Şermin Yalın Sapmaz, Zafer Güleş, Çağatay Uğur, Gülser Şenses Dinç, Semih Erden, Betül Mazlum, Nilufer Okumus, Aysegul Efe, Elif Gokce Ersoy, Basak Ayik, Özlem Bayram, Sabri Hergüner, Yaşar Tanir, Özlem Kahraman, Ayşe Irmak, Necati Uzun, Emine Demirbaş Çakır, Evrim Aktepe, Salih Gençoğlan, Gülseda Ayranci, Nese Coskun, Beril Taskin, Murat Yüce, Ebru Sekmen, Kıvanç Kudret Berberoğlu, Mustafa Yasin Irmak, Murat Coskun, Zehra Babadağı, Hüseyin Aktaş, Yasemin Yulaf, Gonca Çelik, Nursu Çakin Memik, Devrim Akdemir, Sumeyra Firat, Cihat Kağan Gürkan, Betul Gul Alic, Ibrahim Durukan, Fatih Ünal, Mehmet Fatih Kınık, Gokcen Guven, Ali Evren Tufan, Taciser Uysal, Özlem Özcan, Gulay Gunay, Hatice Aksu, Serkan Suren, Nuran Demir, Burak Açıkel, Sevcan Karakoç Demirkaya, Seyda Celik Goksoy, Savaş Yılmaz, Funda Suleyman, Tuba Mutluer, Dilsad Miniksar Yildiz, Fatma Akkus Ozdemir, Börte Gürbüz Özgür, Ayse Kilincaslan, Mehmet Tekden, Melike Topal, Mehmet Cansiz, Rahime Kadir Mutlu, Veysi Çeri, Senem Başgül, Nazike Yildiz, University of Health Sciences, Bakirkoy Research and Training Hospital for Psychiatric and Neurological Diseases, Child and Adolescent Psychiatry, Istanbul, Turkey, Marmara University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Istanbul, Turkey, Erciyes University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Kayseri, Turkey, Karadeniz Technical University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Trabzon, Turkey, Abant Izzet Baysal University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Bolu, Turkey, Kocaeli University, Department of Psychiatry, Kocaeli, Turkey, Suleyman Demirel University Faculty of Medicine, Department of Child and Adolescent PsychiatryIsparta, Turkey, Adnan Menderes University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Aydin, Turkey, Denizli State Hospital, Child and Adolescent Psychiatry, Denizli, Turkey, Hasan Kalyoncu University, Department of Psychology, Child and Adolescent Psychiatry, Istanbul, Turkey, Manisa Mental Health and Diseases Hospital Child and Adolescent Psychiatry, Manisa, Turkey, Istanbul University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Istanbul, Turkey, Cukurova University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Adana, Turkey, Ataturk University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Erzurum, Turkey, University of Health Sciences Gulhane Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey, Osmangazi University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Eskisehir, Turkey, Yuzuncu Yil University Faculty of Medicine, Department of Child and Adolescent PsychiatryVan, Turkey, Gaziantep University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Gaziantep, Turkey, University of Health Sciences, Bursa Yuksek Ihtisas Hospital, Child and Adolescent Psychiatry, Bursa, Turkey, Trakya University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Edirne, Turkey, Istanbul Medeniyet University, Department of Child and Adolescent Psychiatry, Istanbul, Turkey, Kocaeli University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Kocaeli, Turkey, Ankara University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey, Necmettin Erbakan University Meram Faculty of Medicine, Department of Child and Adolescent Psychiatry, Konya, Turkey, Harran University Faculty of Medicine, Child and Adolescent Psychiatry Department, Sanliurfa, Turkey, Van Training and Research Hospital, Department of Child and Adolescent PsychiatryVan, Turkey, Sakarya University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Sakarya, Turkey, Inonu University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Malatya, Turkey, Celal Bayar University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Manisa, Turkey, Samsun Medical Park Hospital, Child and Adolescent Psychiatry, Samsun, Turkey, Mugla Sitki Kocman University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Mugla, Turkey, Mersin University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Mersin, Turkey, Hacettepe University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey, Uludag University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Bursa, Turkey, Osmaniye State Hospital, Child and Adolescent Psychiatry, Osmaniye, Turkey, Firat University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Elazig, Turkey, Private Practice, Child and Adolescent Psychiatry, Tekirdag, Turkey, Ondokuz Mayis University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Samsun, Turkey, Dicle University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Diyarbakir, Turkey, Kahramanmaras Sutcu Imam University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Kahramanmaras, Turkey, University of Health Sciences, Ankara Child Health and Diseases Hematology and Oncology Training and Research Hospital, Child and Adolescent Psychiatry, Ankara, Turkey, Acibadem Mehmet Ali Aydinlar University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Istanbul, Turkey, Private Doctor, Child and Adolescent Psychiatry, Istanbul, Turkey, Ege University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Izmir, Turkey, Çukurova Üniversitesi, Tıp Fakültesi, Ondokuz Mayıs Üniversitesi, and HKÜ, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümü

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, Adolescent, Turkey, Epidemiology, Child psychopathology, Adjustment disorders, Prevalence, Psychological intervention, Child Welfare, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 0501 psychology and cognitive sciences, Bipolar disorder, Child, Depression (differential diagnoses), Depression, Mood Disorders, Depressive disorder, business.industry, 05 social sciences, social sciences, medicine.disease, Anxiety Disorders, Mental health, eye diseases, Affective disorders, 030227 psychiatry, Epidemiologic Studies, Psychiatry and Mental health, Clinical Psychology, population characteristics, Major depressive disorder, Female, Dysthymic Disorder, business, geographic locations, 050104 developmental & child psychology, Clinical psychology
Abstract

GOKCEN, CEM/0000-0003-3824-5890; Topal, Zehra/0000-0001-8397-5636; Tural, Umit/0000-0002-1593-2180; Unal, Fatih/0000-0001-8386-9884; Acikel, Burak/0000-0002-8964-9513; Erden, Semih/0000-0002-7723-9584; Kilic, Birim Gunay/0000-0002-4566-2564; Ucar, Halit Necmi/0000-0002-2706-7454; CELIK, GONCA/0000-0001-6101-0796; Gunes, Serkan/0000-0002-8247-2145; Isik, Umit/0000-0001-6006-3247; Coskun, Murat/0000-0002-4808-5870; Tufan, ALI EVREN/0000-0001-5207-6240; Donmez, Yunus Emre/0000-0002-7785-2805; Ceri, Veysi/0000-0001-6152-0227; Uzun, Necati/0000-0003-3381-2331; Hesapcioglu, Selma Tural/0000-0002-4816-0228; Kandemir, Hasan/0000-0002-1138-4973; Gormez, Vahdet/0000-0002-2704-9520 WOS: 000439557000070 PubMed: 29936389 Aim: To determine the prevalence of affective disorders in Turkey among a representative sample of Turkish population. Methods: This study was conducted as a part of the "The Epidemiology of Childhood Psychopathology in Turkey" (EPICPAT-T) Study, which was designed by the Turkish Association of Child and Adolescent Mental Health. The inclusion criterion was being a student between the second and fourth grades in the schools assigned as study centers. The assessment tools used were the K-SADS-PL, and a sociodemographic form that was designed by the authors. Impairment was assessed via a 3 point-Likert type scale independently rated by a parent and a teacher. Results: A total of 5842 participants were included in the analyses. The prevalence of affective disorders was 2.5 % without considering impairment and 1.6 % when impairment was taken into account. In our sample, the diagnosis of bipolar disorder was lacking, thus depressive disorders constituted all the cases. Among depressive disorders with impairment, major depressive disorder (MDD) (prevalence of 1.06%) was the most common, followed by dysthymia (prevalence of 0.2%), adjustment disorder with depressive features (prevalence of 0.17%), and depressive disorder-NOS (prevalence of 0.14%). There were no statistically significant gender differences for depression. Maternal psychopathology and paternal physical illness were predictors of affective disorders with pervasive impairment. Conclusion: MDD was the most common depressive disorder among Turkish children in this nationwide epidemiological study. This highlights the severe nature of depression and the importance of early interventions. Populations with maternal psychopathology and paternal physical illness may be the most appropriate targets for interventions to prevent and treat depression in children and adolescents.

Published
2018

4. Misyonerliğin Ticari Penceresi The American Missionary: Reklamlar

Author

Neşe Coşkun

Subjects
misyoner, reklam, the american missionary dergisi, Social sciences (General), H1-99
Abstract

Misyoner kurumları dünyanın farklı coğrafyalarında çalışırken hem kendi faaliyetlerini tanımlamak hem de ayni-nakdi destek toplayabilmek için farklı yayın organlarından faydalanmışlardır. Bu yayınlardan biri The American Missionary dergisidir.1800’lü yılların sonlarında Amerika Birleşik Devletleri’nde Amerikan Misyoner Kurumu’nun (American Missionary Society) yayın organı olan Amerikan Misyonerliği Dergisi (The American Missionary) aylık olarak basılmıştır. Yıllık abonelik bedeli 50 cents olan derginin yönetim adresi Rooms, 56 Reade Street New York’tur. Yayın heyetinde bulunan şahıslar Kalvinist Congregational Church üyesidir ve bu kilisenin nihai amacı tüm dünyada Protestanlık düşüncesini baskın ve etkili kılmaktır. The American Missionary tüm dünyadan Protestan misyonerliği amacıyla toplanan bağışların düzenli olarak yayınlandığı bir periyodiktir ancak yayın masraflarına katkı amacıyla reklam alınmıştır. Ayrıca dünyanın farklı yerlerinde bulunan misyonerlerin ve hedef kitlelerinin ihtiyaç duyabileceği tüm yaşamsal ürünlerin tanıtımının yapılarak, bu şekilde A.B.D. kökenli ürünlerin pazarlanması da amaçlanmıştır. Bu çalışmada 1875-1891 seneleri arasında dergide basılan reklamlar detaylı olarak incelenecek ve misyonerlik faaliyetlerinin sadece din yayma davranışı olmadığı, aynı zamanda ticari kaygıların da söz konusu olduğu ortaya konulacaktır. Amerikan Protestan msyonerliğinin basit bir din yayma davranışı olmadığının ortaya konulması amacıyla telif eserler de incelemeye tabii tutulacaktır.

Published
2021

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