1. Function and mechanism of tumor suppressor gene LRRC4/NGL-2
- Author
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Guiyuan Li, Gang Xu, Minghua Wu, and Peiyao Li
- Subjects
Cancer Research ,Leucine-rich repeat ,Tumor suppressor gene ,Carcinogenesis ,Nerve Tissue Proteins ,Review ,Biology ,medicine.disease_cause ,Methylation ,microRNA ,Gene expression ,medicine ,Humans ,Genes, Tumor Suppressor ,Gene ,Transcription factor ,Cell Proliferation ,miRNA ,Neovascularization, Pathologic ,Glioma ,Oncology ,DNA methylation ,Cancer research ,Molecular Medicine ,Netrin, Netrin-G ligand - Abstract
LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2), a relatively specific expressed gene in brain tissue, is a member of the LRRC4/ NGL (netrin-G ligand) family and belongs to the superfamily of LRR proteins. LRRC4/NGL-2 regulates neurite outgrowth and lamina-specific dendritic segmentation, suggesting that LRRC4/NGL-2 is important for the development of the nervous system. In addition, LRRC4/NGL-2 has been identified as a tumor suppressor gene. The overexpression of LRRC4/NGL-2 suppresses glioma cell growth, angiogenesis and invasion through complicated signaling regulation networks. LRRC4/NGL-2 also has the ability to form multiphase loops with miRNA, transcription factors and gene methylation modification; the loss of LRRC4/NGL-2 function may be an important event in multiple biological processes in gliomas. In summary, LRRC4/NGL-2 is a critical gene in the normal development and tumorigenesis of the nervous system.
- Published
- 2014
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