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1. IMPACT OF HEMOLYSIS DURING MICRO-AXIAL FLOW PUMP SUPPORT ON EARLY OUTCOMES AFTER DURABLE LVAD IMPLANTATION: INSIGHTS FROM AN INTERNATIONAL REGISTRY

Author

Loforte, A., Spitaleri, A., Gallone, G., Lewin, D., Rojas Hernandez, S., Bernhardt, A., Billion, M., Meyer, A., Netuka, I., Kooij, J., Pieri, M., Szymanski, M., Moeller, C., Akhyari, P., Jawad, K., Krasivskyi, I., Schmack, B., Färber, G., Medina, M., Haneya, A., Zimpfer, D., Nersesian, G., Lanmüller, P., Monteleone, G., Oezkur, M., Djordjevic, I., Saeed, D., Boffini, M., Stein, J., Gustafsson, F., Scandroglio, M., Meyns, B., Hofmann, S., Belohlavek, J., Gummert, J., Potapov, E., and Rinaldi, M.

Published
2024
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2. Influence of implant strategy on the transition from temporary left ventricular assist device to durable mechanical circulatory support.

Author

Meyer, A L, Lewin, D, Billion, M, Hofmann, S, Netuka, I, Belohlavek, J, Jawad, K, Saeed, D, Schmack, B, Rojas, S V, Gummert, J, Bernhardt, A, Färber, G, Kooij, J, Meyns, B, Loforte, A, Pieri, M, Scandroglio, A M, Akhyari, P, and Szymanski, M K

Subjects
EXTRACORPOREAL membrane oxygenation, TERMINALLY ill, RENAL replacement therapy, HEART assist devices, CARDIOGENIC shock, CARDIOPULMONARY bypass
Abstract

OBJECTIVES Bridging from a temporary microaxial left ventricular assist device (tLVAD) to a durable left ventricular assist device (dLVAD) is playing an increasing role in the treatment of terminally ill patients with heart failure. Scant data exist about the best implant strategy. The goal of this study was to analyse differences in the dLVAD implant technique and effects on patient outcomes. METHODS Data from 341 patients (19 European centres) who underwent a bridge-to-bridge implant from tLVAD to dLVAD between January 2017 and October 2022 were retrospectively analysed. The outcomes of the different implant techniques with the patient on cardiopulmonary bypass, extracorporeal life support or tLVAD were compared. RESULTS A durable LVAD implant was performed employing cardiopulmonary bypass in 70% of cases (n  = 238, group 1), extracorporeal life support in 11% (n  = 38, group 2) and tLVAD in 19% (n  = 65, group 3). Baseline characteristics showed no significant differences in age (P  = 0.140), body mass index (P  = 0.388), creatinine level (P  = 0.659), the Model for End-Stage Liver Disease (MELD) score (P  = 0.190) and rate of dialysis (P  = 0.110). Group 3 had significantly fewer patients with preoperatively invasive ventilation and cardiopulmonary resuscitation before the tLVAD was implanted (P  = 0.009 and P  < 0.001 respectively). Concomitant procedures were performed more often in groups 1 and 2 compared to group 3 (24%, 37% and 5%, respectively, P  < 0.001). The 30-day mortality data showed significantly better survival after an inverse probability of treatment weighting in group 3, but the 1-year mortality showed no significant differences among the groups (P  = 0.012 and 0.581, respectively). Postoperative complications like the rate of right ventricular assist device (RVAD) implants or re-thoracotomy due to bleeding, postoperative respiratory failure and renal replacement therapy showed no significant differences among the groups. Freedom from the first adverse event like stroke, driveline infection or pump thrombosis during follow-up was not significantly different among the groups. Postoperative blood transfusions within 24 h were significantly higher in groups 1 and 2 compared to surgery on tLVAD support (P  < 0.001 and P  = 0.003, respectively). CONCLUSIONS In our analysis, the transition from tLVAD to dLVAD without further circulatory support did not show a difference in postoperative long-term survival, but a better 30-day survival was reported. The implant using only tLVAD showed a reduction in postoperative transfusion rates, without increasing the risk of postoperative stroke or pump thrombosis. In this small cohort study, our data support the hypothesis that a dLVAD implant on a tLVAD is a safe and feasible technique in selected patients. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Impact of Concomitant Aortic Valve Replacement in Patients with Mild-to-Moderate Aortic Valve Regurgitation Undergoing LVAD Implantation: Propensity Score-Matched Analysis of the EUROMACS Dataset

Author

Loforte, A., primary, Nersesian, G., additional, Gliozzi, G., additional, Gallone, G., additional, Spitaleri, A., additional, Schoenrath, F., additional, Netuka, I., additional, Zimpfer, D., additional, De By, T., additional, Boffini, M., additional, Vendramin, I., additional, Gummert, J., additional, Falk, V., additional, Meyns, B., additional, Rinaldi, M., additional, and Potapov, E., additional

Published
2024
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5. Impact of Hemolysis During Micro-Axial Flow Pump Support on Early Outcomes After Durable LVAD Implantation: Insights from an International Registry

Author

Loforte, A., primary, Gallone, G., additional, Lewin, D., additional, Bernhardt, A., additional, Rojas, S., additional, Billion, M., additional, Meyer, A., additional, Netuka, I., additional, Kooij, J., additional, Pieri, M., additional, Szymanski, M., additional, Moeller, C., additional, Akhyari, P., additional, Jawad, K., additional, Krasivskyi, I., additional, Schmack, B., additional, Farber, G., additional, Medina, M., additional, Haneya, A., additional, Zimpfer, D., additional, Nersesian, G., additional, Lanmueller, P., additional, Spitaleri, A., additional, Oezkur, M., additional, Djordjevic, I., additional, Saeed, D., additional, Stein, J., additional, Kraaijevald, A., additional, De Ferrari, G.M., additional, Boffini, M., additional, Gustafsson, F., additional, Scandroglio, A., additional, Meyns, B., additional, Hofmann, S., additional, Belohlavek, J., additional, Gummert, J., additional, Potapov, E., additional, and Rinaldi, M., additional

Published
2024
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6. Impact of Stroke After Durable LVAD Implantation in Patients Bridged with Micro-Axial Flow Pump: Insights from an International Registry

Author

Loforte, A., primary, Gallone, G., additional, Lewin, D., additional, Bernhardt, A., additional, Rojas, S., additional, Billion, M., additional, Meyer, A., additional, Netuka, I., additional, Kooij, J., additional, Pieri, M., additional, Szymanski, M., additional, Moeller, C., additional, Akhyari, P., additional, Jawad, K., additional, Schmack, B., additional, Farber, G., additional, Medina, M., additional, Haneya, A., additional, Zimpfer, D., additional, Nersesian, G., additional, Lanmueller, P., additional, Spitaleri, A., additional, Oezkur, M., additional, Djordjevic, I., additional, Saeed, D., additional, Stein, J., additional, Kraaijevald, A.O., additional, De Ferrari, G.M., additional, Boffini, M., additional, Gustafsson, F., additional, Scandroglio, A., additional, Meyns, B., additional, Hofmann, S., additional, Belohlavek, J., additional, Gummert, J., additional, Potapov, E., additional, and Rinaldi, M., additional

Published
2024
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7. Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults

Author

Ostadal, B., Ostadalova, I., Szarszoi, O., Netuka, I., Olejnickova, V., and Hlavackova, M.

Subjects
Complications and side effects, Risk factors, Demographic aspects, Health aspects, Anoxia -- Complications and side effects, Myocardial ischemia -- Risk factors -- Demographic aspects, Fetal diseases -- Complications and side effects, Sex differences (Biology) -- Health aspects, Hypoxia -- Complications and side effects
Abstract

Introduction Human epidemiologic studies have shown a clear association of adverse prenatal and early postnatal development and increased risk of ischemic heart disease in adults (Barker et al. 1989). The [...], Epidemiological studies have demonstrated a relationship between the adverse influence of perinatal development and increased risk of ischemic heart disease in adults. From negative factors to which the fetus is subjected, the most important is hypoxia. The fetus may experience hypoxic stress under different conditions, including pregnancy at high altitude, pregnancy with anemia, placental insufficiency, and heart, lung, and kidney disease. One of the most common insults during the early stages of postnatal development is hypoxemia due to congenital cyanotic heart defects. Experimental studies have demonstrated a link between early hypoxia and increased risk of ischemia/reperfusion injury (I/R) in adults. Furthermore, it has been observed that late myocardial effects of chronic hypoxia, experienced in early life, may be sex-dependent. Unlike in males, perinatal hypoxia significantly increased cardiac tolerance to acute I/R injury in adult females, expressed as decreased infarct size and lower incidence of ischemic arrhythmias. It was suggested that early hypoxia may result in sex-dependent programming of specific genes in the offspring with the consequence of increased cardiac susceptibility to I/R injury in adult males. These results would have important clinical implications, since cardiac sensitivity to oxygen deprivation in adult patients may be significantly influenced by perinatal hypoxia in a sex-dependent manner. Key words: heart, perinatal hypoxia, ischemia/reperfusion injury, sex differences. Les etudes epidemiologiques ont montre un lien entre des influences defavorables du developpement perinatal et l&apos;accroissement du risque de maladie cardiaque ischemique chez l&apos;adulte. L&apos;hypoxie est le plus important facteur negatif auquel le foetus puisse etre expose. Le foetus peut etre expose a un stress hypoxique dans differentes situations, comme la grossesse a une altitude elevee, la grossesse en anemie, l&apos;insuffisance placentaire et des maladies du coeur, des poumons et des reins. L&apos;une des agressions les plus frequentes que le foetus puisse subir au cours des stades precoces du developpement postnatal est l&apos;hypoxie causee par des malformations cardiaques congenitales cyanotiques. Des etudes experimentales ont montre un lien entre l&apos;hypoxie precoce et l&apos;accroissement du risque de lesions d&apos;ischemie/reperfusion (I/R) chez l&apos;adulte. En outre, on a observe que des effets myocardiques tardifs de l&apos;hypoxie chronique subie au debut de la vie pourraient varier en fonction du sexe. Contrairement a chez les males, l&apos;hypoxie perinatale chez les femelles adultes entrainait une augmentation marquee de la tolerance du coeur aux lesions d&apos;I/R aigues, avec une diminution de la taille de l&apos;infarctus et de la frequence des arythmies ischemiques. On a laisse entendre que l&apos;hypoxie precoce pourrait entrainer la programmation dependante du sexe de genes specifiques chez les rejetons et consequemment un accroissement de la susceptibilite du coeur aux lesions d&apos;I/R chez les adultes males. Ces resultats pourraient avoir des repercussions cliniques importantes, puisque la sensibilite du coeur au manque d&apos;oxygene chez des patients adultes pourrait etre influencee de facon notable par l&apos;hypoxie perinatale, avec des effets variables selon le sexe. [Traduit par la Redaction] Mots-cles : coeur, hypoxie perinatale, lesions d&apos;ischemie/reperfusion, differences entre les sexes.

Published
2021
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10. PB1371 Platelet Activation with the Aeson Bioprosthetic Total Artificial Heart: Insight from Aspirin Treatment and Outcomes

Author

Smadja, D., primary, Peronino, C., additional, Jilet, L., additional, Ivak, P., additional, Pia, Y., additional, Philippe, A., additional, Latremouille, C., additional, Gustafsson, F., additional, Ramjankhan, F., additional, Roussel, J., additional, Vincentelli, A., additional, Flecher, E., additional, Gaussem, P., additional, Jansen, P., additional, and Netuka, I., additional

Published
2023
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12. Preconditioning with Different Types of Micro-axial Flow Pump as a Bridge to a Left Ventricular Assist Device.

Author

Medina, M.L., Oezkur, M., Lewin, D., Hernandez, S. Rojas, Bernhardt, A., Billion, M., Meyer, A., Netuka, I., Pieri, M., Ihor, K., Djordjevic, I., Loforte, A., Akhyari, P., Jawad, K., Schmack, B., Färber, G., Haneya, A., Zimpfer, D., Nersesian, G., and Saeed, D.

Subjects
HEART assist devices, EXTRACORPOREAL membrane oxygenation
Abstract

This article discusses the outcomes associated with different types of micro-axial flow pumps (mAFPs) used in patients with acute decompensated heart failure who require left ventricular assist device (LVAD) support. The study analyzes data from a multicenter registry and stratifies patients into three groups based on the flow provided by each mAFP variant. The results show that the use of higher-flow mAFPs is associated with improved outcomes, including a reduction in inotropic scores and a decreased incidence of postoperative complications. The study suggests that higher-flow mAFPs may enhance patient recovery and facilitate myocardial unloading. However, there was no statistically significant difference in 30-day mortality between the groups. [Extracted from the article]

Published
2024
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14. The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update

Author

Saeed, D, Feldman, D, Banayosy, Ae, Birks, E, Blume, E, Cowger, J, Hayward, C, Jorde, U, Kremer, J, Macgowan, G, Maltais, S, Maybaum, S, Mehra, M, Shah, Kb, Mohacsi, P, Schweiger, M, Schroeder, Se, Shah, P, Slepian, M, Tops, Lf, Alvarez, P, Arabia, F, Aslam, S, Benson-Louis, L 4th, Birati, E, Buchholz, Hw, Cedars, A, Christensen, D, Ciarka, A, Coglianese, E, Cogswell, R, Cook, J, Copeland, J, Costello, Jg, Drakos, Sg, Eghtesady, P, Elliot, T, Estep, Jd, Eulert-Grehn, Jj, Fabrizio, R, Garbade, J, Gelow, J, Guglin, M, Hernandez-Montfort, J, Horstmanshof, D, John, R, Kanwar, M, Khaliel, F, Kim, G, Kumar, S, Lavee, J, Leache, M, Leprince, P, Lim, S, Loforte, Antonino, Maly, J, Najjar, S, Netuka, I, Pamboukian, Sv, Patel, Sr, Pinney, S, Pluym, Cv, Potapov, E, Robson, D, Rochlani, Y, Russell, S, Sandau, K, Sandoval, E, Sayer, G, Schettle, S, Schibilsky, D, Schlöglhofer, T, Schmitto, J, Siddique, A, Silvestry, S, Slaughter, Ms, Sun, B, Takayama, H, Tedford, R, Teuteberg, Jj, Ton, Vk, Uriel, N, Vierecke, J, Zimpfer, D, and D'Alessandro, D.

Subjects
Pulmonary and Respiratory Medicine, Transplantation, Surgery, Cardiology and Cardiovascular Medicine
Published
2023

16. A Multi-Center Evaluation of Outflow Graft Obstruction with a Fully Magnetically Levitated Left Ventricular Assist Device

Author

Wert, L., primary, Stewart, G.C., additional, Mehra, M.R., additional, Milwidsky, A., additional, Jorde, U.P., additional, Goldstein, D.J., additional, Selzman, C.H., additional, Stehlik, J., additional, Alshamdin, F.D., additional, Khaliel, F.H., additional, Gustafsson, F., additional, Boschi, S., additional, Loforte, A., additional, Ajello, S., additional, Scandroglio, A.M., additional, Tučanová, Z., additional, Netuka, I., additional, Schlöglhofer, T., additional, Zimpfer, D., additional, Dogan, G., additional, Schmitto, J.D., additional, Maier, S., additional, Schibilsky, D., additional, Jawad, K., additional, Saeed, D., additional, Faerber, G., additional, Morshuis, M., additional, Hanuna, M., additional, Müller, C.S., additional, Mulzer, J., additional, Kempfert, J., additional, Falk, V., additional, and Potapov, E.V., additional

Published
2022
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18. Impact of Concomitant Cardiac Valvular Surgery During Implantation of Continuous-Flow Left Ventricular Assist Devices: A European Registry for Patients with Mechanical Circulatory Support (EUROMACS) Analysis

Author

Loforte, A., primary, de By, T., additional, Gliozzi, G., additional, Schoenrath, F., additional, Cavalli, G., additional, Netuka, I., additional, Pya, Y., additional, Zimpfer, D., additional, Boschi, S., additional, Gummert, J., additional, Meyns, B., additional, Pacini, D., additional, and Potapov, E., additional

Published
2022
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20. (580) - Impact of Stroke After Durable LVAD Implantation in Patients Bridged with Micro-Axial Flow Pump: Insights from an International Registry

Author

Loforte, A., Lewin, D., Bernhardt, A., Rojas, S., Billion, M., Meyer, A., Netuka, I., Kooij, J., Pieri, M., Szymanski, M., Moeller, C., Akhyari, P., Jawad, K., Schmack, B., Farber, G., Medina, M., Haneya, A., Zimpfer, D., Nersesian, G., Lanmueller, P., Spitaleri, A., Oezkur, M., Djordjevic, I., Saeed, D., Stein, J., Kraaijevald, A.O., De Ferrari, G.M., Boffini, M., Gustafsson, F., Scandroglio, A., Meyns, B., Hofmann, S., Belohlavek, J., Gummert, J., Potapov, E., and Rinaldi, M.

Published
2024
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22. (244) - Impact of Hemolysis During Micro-Axial Flow Pump Support on Early Outcomes After Durable LVAD Implantation: Insights from an International Registry

Author

Loforte, A., Lewin, D., Bernhardt, A., Rojas, S., Billion, M., Meyer, A., Netuka, I., Kooij, J., Pieri, M., Szymanski, M., Moeller, C., Akhyari, P., Jawad, K., Krasivskyi, I., Schmack, B., Farber, G., Medina, M., Haneya, A., Zimpfer, D., Nersesian, G., Lanmueller, P., Spitaleri, A., Oezkur, M., Djordjevic, I., Saeed, D., Stein, J., Kraaijevald, A., De Ferrari, G.M., Boffini, M., Gustafsson, F., Scandroglio, A., Meyns, B., Hofmann, S., Belohlavek, J., Gummert, J., Potapov, E., and Rinaldi, M.

Published
2024
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27. Clinical impact and 'natural' course of uncorrected tricuspid regurgitation after implantation of a left ventricular assist device: an analysis of the European Registry for Patients with Mechanical Circulatory Support (EUROMACS)

Author

Veen, K.M. (Kevin), Mokhles, M.M. (Mostafa), Soliman, O.I.I. (Osama Ibrahim Ibrahim), By, T.M.M.H. (Theo) de, Mohacsi, P. (Paul), Schoenrath, F. (Felix), Paluszkiewicz, L. (Lech), Netuka, I. (Ivan), Bogers, A.J.J.C. (Ad J J C), Takkenberg, J.J.M. (Hanneke), Caliskan, K.C. (Kadir), Veen, K.M. (Kevin), Mokhles, M.M. (Mostafa), Soliman, O.I.I. (Osama Ibrahim Ibrahim), By, T.M.M.H. (Theo) de, Mohacsi, P. (Paul), Schoenrath, F. (Felix), Paluszkiewicz, L. (Lech), Netuka, I. (Ivan), Bogers, A.J.J.C. (Ad J J C), Takkenberg, J.J.M. (Hanneke), and Caliskan, K.C. (Kadir)

Abstract

OBJECTIVES: Data on the impact and course of uncorrected tricuspid regurgitation (TR) during left ventricular assist device (LVAD) implantation are scarce and inconsistent. This study explores the clinical impact and natural course of uncorrected TR in patients after LVAD implantation. METHODS: The European Registry for Patients with Mechanical Circulatory Support was used to identify adult patients with LVAD implants without concomitant tricuspid valve surgery. A mediation model was developed to assess the association of TR with 30-day mortality via other risk factors. Generalized mixed models were used to model the course of post-LVAD TR. Joint models were used to perform sensitivity analyses. RESULTS: A total of 2496 procedures were included (median age: 56 years; men: 83%). TR was not directly associated with higher 30-day mortality, but mediation analyses suggested an indirect association via preoperative elevated right atrial pressure and creatinine (P = 0.035) and bilirubin (P = 0.027) levels. Post-LVAD TR was also associated with increased late mortality [hazard ratio 1.16 (1.06-1.3); P = 0.001]. On average, uncorrected TR diminished after LVAD implantation. The probability of having moderate-to-severe TR immediately after an implant in patients with none-to-mild TR pre-LVAD was 10%; in patients with moderate-to-severe TR pre-LVAD, it was 35% and continued to decrease in patients with moderate-to-severe TR pre-LVAD, regardless of pre-LVAD right ventricular failure or pulmonary hypertension. CONCLUSIONS: Uncorrected TR pre-LVAD and post-LVAD is associated with increased early and late mortality. Nevertheless, on average, TR diminishes progre

Published
2021
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28. Clinical impact and 'natural' course of uncorrected tricuspid regurgitation after implantation of a left ventricular assist device: an analysis of the European Registry for Patients with Mechanical Circulatory Support (EUROMACS)

Author

Veen, Kevin, Mokhles, Mostafa, Soliman, Osama, de By, TMMH, Mohacsi, P, Schoenrath, F, Paluszkiewicz, L, Netuka, I, Bogers, Ad, Takkenberg, Hanneke, Caliskan, Kadir, Veen, Kevin, Mokhles, Mostafa, Soliman, Osama, de By, TMMH, Mohacsi, P, Schoenrath, F, Paluszkiewicz, L, Netuka, I, Bogers, Ad, Takkenberg, Hanneke, and Caliskan, Kadir

Abstract

Objectives: Data on the impact and course of uncorrected tricuspid regurgitation (TR) during left ventricular assist device (LVAD) implantation are scarce and inconsistent. This study explores the clinical impact and natural course of uncorrected TR in patients after LVAD implantation. Methods: The European Registry for Patients with Mechanical Circulatory Support was used to identify adult patients with LVAD implants without concomitant tricuspid valve surgery. A mediation model was developed to assess the association of TR with 30-day mortality via other risk factors. Generalized mixed models were used to model the course of post-LVAD TR. Joint models were used to perform sensitivity analyses. Results: A total of 2496 procedures were included (median age: 56 years; men: 83%). TR was not directly associated with higher 30-day mortality, but mediation analyses suggested an indirect association via preoperative elevated right atrial pressure and creatinine (P = 0.035) and bilirubin (P = 0.027) levels. Post-LVAD TR was also associated with increased late mortality [hazard ratio 1.16 (1.06-1.3); P = 0.001]. On average, uncorrected TR diminished after LVAD implantation. The probability of having moderate-to-severe TR immediately after an implant in patients with none-to-mild TR pre-LVAD was 10%; in patients with moderate-to-severe TR pre-LVAD, it was 35% and continued to decrease in patients with moderate-to-severe TR pre-LVAD, regardless of pre-LVAD right ventricular failure or pulmonary hypertension. Conclusions: Uncorrected TR pre-LVAD and post-LVAD is associated with increased early and late mortality. Nevertheless, on average, TR diminishes progressively without intervention after an LVAD implant. Therefore, these data suggest that patient selection for concomitant tricuspid valve surgery should not be based solely on TR grade.

Published
2021

39. Outcomes of patients after successful left ventricular assist device explantation: a EUROMACS study

Author

Antonides, C.F.J. (Christiaan F.J.), Schoenrath, F. (Felix), de By, T.M.M.H. (Theo M.M.H.), Muslem, R. (Rahatullah), Veen, K.M. (Kevin), Yalcin, Y.C. (Yunus C.), Netuka, I. (Ivan), Gummert, J. (Jan Fritz), Potapov, E.V. (Evgenij V.), Meyns, B. (Bart), Özbaran, M. (Mustafa), Schibilsky, D. (David), Caliskan, K.C. (Kadir), Antonides, C.F.J. (Christiaan F.J.), Schoenrath, F. (Felix), de By, T.M.M.H. (Theo M.M.H.), Muslem, R. (Rahatullah), Veen, K.M. (Kevin), Yalcin, Y.C. (Yunus C.), Netuka, I. (Ivan), Gummert, J. (Jan Fritz), Potapov, E.V. (Evgenij V.), Meyns, B. (Bart), Özbaran, M. (Mustafa), Schibilsky, D. (David), and Caliskan, K.C. (Kadir)

Abstract

Aims: Sufficient myocardial recovery with the subsequent explantation of a left ventricular assist device (LVAD) occurs in approximately 1–2% of the cases. However, follow-up data about this condition are scarcely available in the literature. This study aimed to report the long-term outcomes and clinical management following LVAD explantation. Methods and results: An analysis of the European Registry for Patients with Mechanical Circulatory Support was performed to identify all adult patients with myocardial recovery and successful explantation. Pre-implant characteristics were retrieved and compared with the non-recovery patients. The follow-up data after explantation were collected via a questionnaire. A Kaplan–Meier analysis for freedom of the composite endpoint of death, heart transplantation, LVAD reimplantion, or heart failure (HF) relapse was conducted. A total of 45 (1.4%) cases with myocardial recovery resulting in successful LVAD explantation were identified. Compared with those who did not experience myocardial recovery, the explanted patients were younger (44 vs. 56 years, P < 0.001), had a shorter duration of cardiac disease (P < 0.001), and were less likely to have ischaemic cardiomyopathy (9% vs. 41.8%, P < 0.001). Follow-up after explantation could be acquired in 28 (62%) cases. The median age at LVAD implantation was 43 years (inter-quartile range: 29–52), a

Published
2020
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45. 2019 EACTS Expert Consensus on long-term mechanical circulatory support

Author

Potapov E.V., Antonides C., Crespo-Leiro M.G., Combes A., Färber G., Hannan M.M., Kukucka M., De Jonge N., Loforte A., Lund L.H., Mohacsi P., Morshuis M., Netuka I., Özbaran M., Pappalardo F., Scandroglio A.M., Schweiger M., Tsui S., Zimpfer D., Gustafsson F., The Task Force on Long-Term Mechanical Circulatory Support of the EACTS, Ege Üniversitesi, University of Zurich, Potapov, Evgenij V, Cardiothoracic Surgery, Antonides, Christiaan, Crespo-Leiro, Maria G, Combes, Alain, Färber, Gloria, Hannan, Margaret M, Kukucka, Marian, de Jonge, Nicolaa, Loforte, Antonio, Lund, Lars H, Mohacsi, Paul, Morshuis, Michiel, Netuka, Ivan, Özbaran, Mustafa, Pappalardo, Federico, Scandroglio, Anna Mara, Schweiger, Martin, Tsui, Steven, Zimpfer, Daniel, and Gustafsson, Finn

Subjects
medicine.medical_treatment, Expert consensus, Left ventricular assist device, 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, Postoperative Complications, Multidisciplinary approach, law, Medicine, Rehabilitation, Expert consensu, General Medicine, Intensive care unit, 2746 Surgery, Eacts/27, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, Eacts/22, Left ventricular assist devices, InformationSystems_MISCELLANEOUS, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, 610 Medicine & health, Heart failure, Preoperative care, Perioperative Care, 2705 Cardiology and Cardiovascular Medicine, Prosthesis Implantation, 03 medical and health sciences, Ambulatory care, Mechanical circulatory support, Journal Article, Humans, 10220 Clinic for Surgery, Cardiac Surgical Procedures, Intensive care medicine, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, medicine.disease, Comorbidity, Editor's Choice, ComputingMethodologies_PATTERNRECOGNITION, 030228 respiratory system, 2740 Pulmonary and Respiratory Medicine, Ventricular assist device, Surgery, Heart-Assist Devices, business, Reports
Abstract

Gustafsson, Finn/0000-0003-2144-341X; Crespo-Leiro, Maria Generosa/0000-0002-3085-167X; Loforte, Antonio/0000-0002-3689-0477; Zimpfer, Daniel/0000-0002-2185-4895, WOS: 000493090200005, PubMed: 31100109, Long-term mechanical circulatory support (LT-MCS) is an important treatment modality for patients with severe heart failure. Different devices are available, and many-sometimes contradictory-observations regarding patient selection, surgical techniques, perioperative management and follow-up have been published. With the growing expertise in this field, the European Association for Cardio-Thoracic Surgery (EACTS) recognized a need for a structured multidisciplinary consensus about the approach to patients with LT-MCS. However, the evidence published so far is insufficient to allow for generation of meaningful guidelines complying with EACTS requirements. Instead, the EACTS presents an expert opinion in the LT-MCS field. This expert opinion addresses patient evaluation and preoperative optimization as well as management of cardiac and non-cardiac comorbidities. Further, extensive operative implantation techniques are summarized and evaluated by leading experts, depending on both patient characteristics and device selection. the faculty recognized that postoperative management is multidisciplinary and includes aspects of intensive care unit stay, rehabilitation, ambulatory care, myocardial recovery and end-of-life care and mirrored this fact in this paper. Additionally, the opinions of experts on diagnosis and management of adverse events including bleeding, cerebrovascular accidents and device malfunction are presented. in this expert consensus, the evidence for the complete management from patient selection to end-of-life care is carefully reviewed with the aim of guiding clinicians in optimizing management of patients considered for or supported by an LT-MCS device.

Published
2019
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48. Intraventricular placement of a spring expander does not attenuate cardiac atrophy of the healthy heart induced by unloading via heterotopic heart transplantation

Author

Pokorný, J., primary, Mrázová, I., additional, Kubátová, H., additional, Piťha, J., additional, Malý, J., additional, Pirk, J., additional, Maxová, H., additional, Melenovský, V., additional, Šochman, J., additional, Sadowski, J., additional, Červenka, L., additional, Čermák, Z., additional, Volenec, K., additional, and Netuka, I., additional

Published
2019
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49. Longitudinal Impact of Temporary Mechanical Circulatory Support on Durable Left Ventricular Assist Device Outcomes: An IMACS Registry Analysis

Author

Hernandez-Montfort, J.A., primary, Ton, V. Khue, additional, Xie, R., additional, Fisher, A., additional, Meyns, B., additional, Nakatani, T., additional, Netuka, I., additional, Pettit, S., additional, Shaw, S., additional, Yanase, M., additional, Kirklin, J.K., additional, Rowe, A., additional, Goldstein, D.J., additional, and Cowger, J., additional

Published
2019
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