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2. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Author

Thomas, Caradog, Rahman, Meshbah, Yapp, Tom, Lye Ch'ng, Chin, Harrison, Melanie, Sturgess, Richard, Galaska, Roman, Healey, Chris, Whiteman, Jessica, Czaijkowski, Marek, Gray, Catherine, Gunasekera, Anton, Gyawli, Pranab, Premchand, Purushothaman, Mann, Steven, Elliott, Keith, Kapur, Kapil, Watson, Alan, Foster, Graham, Trembling, Paul, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Adgey, Carolyn, Hobson, Lucie, Mulvaney-Jones, Caroline, Evans, Richard, Mathialahan, Thiriloganathan, Ramanaden, David, Gasem, Jaber, Van Duyvenvoorde, Greta, Shorrock, Christopher, Seward, Katie, Southern, Paul, Tibble, Jeremy, Penn, Ruth, Gorard, David, Maiden, Jane, Damant, Rose, Palegwala, Altaf, Jones, Susan, Alexander, Graeme, Mells, George, Sandford, Richard, Dolwani, Sunil, Prince, Martin, Silvestre, Valeria, Foxton, Matthew, Dungca, Eleanor, Mitchison, Harriet, Wheatley, Natalie, Gooding, Ian, Doyle, Helen, Karmo, Mazn, Kent, Melanie, Saksena, Sushma, Braim, Delyth, Patel, Minesh, Lord, Susan, Ede, Roland, Paton, Alison, Austin, Andrew, Lancaster, Nicola, Sayer, Joanna, Gibbins, Andrew, Hogben, Karen, Hovell, Chris, Fisher, Neil, Carter, Martyn, Koss, Konrad, Musselwhite, Janine, Muscariu, Florin, Piotreowicz, Andrzej, McKay, Alexandra, Grimley, Charles, Neal, David, Ting Tan, Lai, Lim, Guan, Brighton, Jacqueline, Foale, Carole, Ala, Aftab, Saeed, Athar, Flahive, Kerry, Wood, Gordon, Townshend, Paula, Ford, Chris, Brown, Jonathan, Kordula, Jean, Bowles, Jane, Wilkinson, Mark, Palmer, Caroline, Ramage, John, Gordon, Harriet, Featherstone, James, Ridpath, Jo, Ngatchu, Theodore, Levi, Sass, Shaukat, Syed, Sadeghian, Joy, Shidrawi, Ray, Williams, Bronwen, Abouda, George, Jones, Sarah, Duggan, Claire, Hynes, Abigail, Narain, Mark, Rees, Ian, Salam, Imroz, Crossey, Mary, Taylor-Robinson, Simon, Brown, Ashley, MacNicol, Carolyn, Williams, Simon, Wilhelmsen, Elva, Banim, Paul, Raymode, Parizade, Chilton, Andrew, Das, Debasish, Lee, Hye-Jeong, Curtis, Howard, Heneghan, Michael, Gess, Markus, Durant, Emma, Drake, IM, Bishop, Rebecca, Davies, Mervyn, Jones, Rebecca, Aldersley, Mark, Ncube, Noma, McNair, Alistair, Srirajaskanthan, Raj, Sen, Sambit, Casey, Rebecca, Bird, George, Mendall, Mike, Cowley, Caroline, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Amore, Kelly, Sirdefield, Dawn, Orpe, Jacky, Mathew, Ray, MacFaul, George, Wrigth, Aruna, Shah, Amir, Evans, Chris, Keggans, Janie, Bird, Bridget, Baxter, Gwen, Saha, Subrata, Pollock, Katharine, Hughes, Maggie, Bramley, Peter, Grieve, Emma, Young, Karin, Fraser, Andrew, Mukhopadhya, Ashis, Ocker, Kate, Mills, Peter, Hines, Francis, Shallcross, Chris, Wilkins, Joy, Grellier, Leonie, Campbell, Stewart, Martin, Kirsty, Bathgate, Andrew, Innes, Caron, Shepherd, Alan, Rushbrook, Simon, Valliani, Talal, Przemioslo, Robert, Fairlamb, Helen, Macdonald, Chris, Eastick, Anne, Metcalf, Jane, Tanqueray, Elizabeth, Shmueli, Udi, Holbrook, Becky, Davis, Andrew, Browning, Julie, Naqvi, Asifabbas, Walker, Kirsten, Lee, Tom, Verheyden, Juliette, Slininger, Susan, Ryder, Stephen D, Chapman, Roger, Collier, Jane, O'Donnell, Denise, Stafford, Lizzie, Williamson, Kate, Kent, Linda, Klass, Howard, Ninkovic, Mary, March, Linda, Cramp, Matthew, Simpson, Diane, Dickson, Christine, Sharer, Nicholas, Hayes, Maria, Goggin, Patrick, Quinne, Mary, Pearson, Sallyanne, Hoeroldt, Barbara, Jones, Linda, Wright, Alice, Booth, Jonathan, Loftus, Alison, Lipscomb, George, Dewhurst, Hannah, Gunter, Emma, Williams, Earl, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Hussaini, Hyder, Stableforth, Bill, Marriott, Suzie, Ayres, Reuben, Leoni, Marina, Burroughs, Andrew, Marshall, Eileen, Thorburn, Douglas, Tyrer, David, Martin, Kate, Lombard, Martin, Patanwala, Imran, Dali-Kemmery, Lola, Lambourne, Victoria, Maltby, Julia, Vyas, Samir, Colley, Julie, Shinder, Bal, Singhal, Saket, Jones, Jayne, Mills, Marisa, Gleeson, Dermot, Carnahan, Mandy, Butterworth, Jeff, Boulton, Kerenza, Taylor, Natalie, George, Keith, Harding, Tim, Tregonning, Julie, Douglass, Andrew, Brown, Carly, Clifford, Gayle, Panter, Simon, Gocher, Denise, Shearman, Jeremy, Bray, Gary, Hamilton, Maria, Butcher, Graham, Forton, Daniel, Mclindon, John, Curtis, Janette, Das, Debashis, Shewan, Tracey, Cowan, Matthew, Whatley, Gregory, Nasseri, Mariam, Grover, Bob, Sivaramakrishnan, Nurani, Ducker, Samantha, Houghton, Kathryn, Jones, David, Griffiths, Laura, Tripoli, Sherill, Pitcher, Maxton, Shpuza, Ervin, White, Nikki, Ghosh, Deb, Douds, Andrew, Green, Marie, Brookes, Matthew, Cumlat, Lourdes, Wong, Voi Shim, Warner, Karen, Netherton, Kimberley, Mandal, Adtya, Jain, Snjiv, Gupta, Hemant, Sanghi, Pradeep, Pereira, Steve, Neuberger, James, Gunson, Bridget, Hirschfield, Gideon, Lim, Reina Teegan, Gallagher, Susan, Clement, Darren, Brind, Alison, Watts, Gill, Mupudzi, Mcdonald, Wright, Mark, Gitahi, Jane, Gordon, Fiona, Gocher, Denis, Unitt, Esther, Pateman, Hilary, Batham, Sally, Delahooke, Toby, Grant, Allister, Conder, Jill, Higham, Andrew, Cox, Mark, O'Donohoe, Lynn, Currie, Lynn, King, Alistair, Oblak, Metod, Collins, Carole, Whalley, Simon, Quinn, Marie, Baird, Yolanda, Amey, Isobel, Fraser, Jocelyn, Li, Andy, Cotterill, Donna, Bell, Andrew, Singhal, Amit, Gee, Ian, Greer, Sandra, Ang, Yeng, Ransford, Rupert, Allison, Joanna, Gotto, James, Dyer, Simon, Sweeting, Helen, Millson, Charles, Invernizzi, Pietro, Carbone, Marco, Cristoferi, Laura, Bonato, Giulia, Malinverno, Federica, Bernuzzi, Francesca, Alvaro, Domenico, Labbadia, Giancarlo, Bragazzi, Maria Consiglia, Andreone, Pietro, Muratori, Luigi, Azzaroli, Francesco, Floreani, Annarosa, Galli, Andrea, Tarocchi, Mirko, Giannini, Edoardo, Miele, Luca, Gasbarrini, Antonio, Grieco, Antonio, Marrone, Giuseppe, Donato, Maria Francesca, Valenti, Luca, Marra, Fabio, Marzioni, Marco, Maroni, Luca, Rigamonti, Cristina, Zuin, Massimo, Battezzati, Pier Maria, Picciotto, Antonino, Nardi, Alessandra, Flack, Steve, Carpino, Guido, Varvaropoulou, Nikoletta, Gavrila, Caius, Spicer, Ann, Badrock, Jonathan, Cardinale, Vincenzo, Ainsworth, Holly F, Heneghan, Michael A, Neuberger, James M, Donato, Maria F, Kirby, John, Mitchell-Thain, Robert, Sampaziotis, Fotios, Gaudio, Eugenio, Ronca, Vincenzo, Gerussi, Alessio, Stocken, Deborah D, Cordell, Heather J, Hirschfield, Gideon M, Alexander, Graeme J, Sandford, Richard N, Jones, David E, and Mells, George F

Published
2018
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4. Organ Transplants From Deceased Donors With Primary Brain Tumors and Risk of Cancer Transmission

Author

Greenhall, George H. B., primary, Rous, Brian A., additional, Robb, Matthew L., additional, Brown, Chloe, additional, Hardman, Gillian, additional, Hilton, Rachel M., additional, Neuberger, James M., additional, Dark, John H., additional, Johnson, Rachel J., additional, Forsythe, John L. R., additional, Tomlinson, Laurie A., additional, Callaghan, Chris J., additional, and Watson, Christopher J. E., additional

Published
2023
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7. The UK-PBC Risk Scores: Derivation and Validation of a Scoring System for Long-Term Prediction of End-Stage Liver Disease in Primary Biliary Cholangitis

Author

Carbone, Marco, Sharp, Stephen J., Flack, Steve, Paximadas, Dimitrios, Spiess, Kelly, Adgey, Carolyn, Griffiths, Laura, Lim, Reyna, Trembling, Paul, Williamson, Kate, Wareham, Nick J., Aldersley, Mark, Bathgate, Andrew, Burroughs, Andrew K., Heneghan, Michael A., Neuberger, James M., Thorburn, Douglas, Hirschfield, Gideon M., Cordell, Heather J., Alexander, Graeme J., Jones, David E.J., Sandford, Richard N., and Mells, George F.

Published
2016
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8. List of Contributors

Author

Afroze, Syeda H., primary, Alpini, Gianfranco, additional, Anderson, Eric C., additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Baiguera, Silvia, additional, Baiocchi, Leonardo, additional, Baptista, Pedro M., additional, Bejarano-Pineda, Lorena, additional, Benedetti, Enrico, additional, Beraldi, Rosanna, additional, Berdichevski, Alexandra, additional, Bhuyan, Mohammod, additional, Bishop, Alex G., additional, Bitar, Khalil N., additional, Blose, Kory J., additional, Brasile, Lauren, additional, Braza, Faouzi, additional, Breuer, Christopher K., additional, Brouard, Sophie, additional, Brown, Bryan N., additional, Burke, George W., additional, Butler, Peter E., additional, Butler, Colin R., additional, Calderon, Damelys, additional, Cancedda, Ranieri, additional, Cantero Peral, Susana, additional, Carbone, Marco, additional, Castanares-Zapatero, Diego, additional, Castro Santa, Edward, additional, Chatenoud, Lucienne, additional, Chawla, Reema, additional, Chen, Linda, additional, Chiono, Valeria, additional, Ciancio, Gaetano, additional, Ciardelli, Gianluca, additional, Ciccarelli, Olga, additional, Collienne, Christine, additional, Corradini, Francesca, additional, Cortiella, Joaquin, additional, Cravedi, Paolo, additional, Cypel, Marcelo, additional, Da Sacco, Stefano, additional, Date, Hiroshi, additional, Davies, Paige S., additional, De Coppi, Paolo, additional, De Luca, Michele, additional, Dean, Ethan W., additional, Degauque, Nicolas, additional, Domínguez-Bendala, Juan, additional, Dubernard, Jean Michel, additional, ElBackly, Rania M., additional, English, Karen, additional, Fändrich, Fred, additional, Farney, Alan C., additional, Faulk, Denver M., additional, García-Arrarás, José E., additional, Gianello, Pierre, additional, Giangreco, Adam, additional, Glaser, Shannon S., additional, Gobble, Ryan, additional, Goldstein, Aaron S., additional, Grant, Christa N., additional, Grikscheit, Tracy C., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, Guillot, Pascale V., additional, Hamilton, Nicholas, additional, Hantson, Philippe, additional, Hemal, Sij, additional, Hematti, Peiman, additional, Hynds, Robert E., additional, Inverardi, Luca, additional, Jacquet, Luc M., additional, Janes, Sam M., additional, Jell, Gavin, additional, Jensen, Kendal, additional, Jochmans, Ina, additional, Kanai, Nobuo, additional, Katari, Ravi, additional, Keshavjee, Shaf, additional, Kim, Jaehyup, additional, Kim, Yeonhee, additional, King, Nancy M.P., additional, Kobayashi, Eiji, additional, Koshiba, Takaaki, additional, Krawiec, Jeffrey T., additional, Kurobe, Hirotsugu, additional, Lai, Quirino, additional, Lanzoni, Giacomo, additional, Laterre, Pierre-François, additional, Lerut, Jan P., additional, Lerut, Toni, additional, Li, Ou, additional, Macchiarini, Paolo, additional, Maghsoudlou, Panagiotis, additional, Mamode, Nizam, additional, Manzia, Tommaso M., additional, Martinez-Fernandez, Almudena, additional, Martovetsky, Gleb, additional, Mastrogiacomo, Maddalena, additional, Masuda, Shigeo, additional, McQuilling, John P., additional, Mehra, Mandeep R., additional, Menasché, Philippe, additional, Meng, Fanyin, additional, Mironi-Harpaz, Iris, additional, Mirzazadeh, Majid, additional, Moiemen, Naiem S., additional, Moran, Emma, additional, Muiesan, Paolo, additional, Nardo, Tiziana, additional, Nelson, Timothy J, additional, Netti, Paolo A., additional, Neuberger, James M., additional, Nigam, Sanjay K., additional, Ohe, Hidenori, additional, Okano, Teruo, additional, Opara, Emmanuel C., additional, Orgill, Dennis P., additional, Otte, Jean-Bernard, additional, Ozer, Sinan, additional, Pareta, Rajesh A., additional, Patel, Timil, additional, Pellegrini, Graziella, additional, Peloso, Andrea, additional, Perin, Laura, additional, Petruzzo, Palmina, additional, Pinheiro, Rafael S., additional, Pirenne, Jacques, additional, Poindexter, Lauren K., additional, Pucéat, Michel, additional, Pugliese, Alberto, additional, Raghavan, Shreya, additional, Rahal, Kinan, additional, Rama, Paolo, additional, Remuzzi, Andrea, additional, Remuzzi, Giuseppe, additional, Reyna-Soriano, Daniel, additional, Rico Juri, Juan M., additional, Ricordi, Camillo, additional, Roberts, Keith J., additional, Rocco, Kevin A., additional, Rodriguez-Devora, Jorge I., additional, Rogers, Jeffrey, additional, Rudnick, David A., additional, Ruggenenti, Piero, additional, Sageshima, Junichiro, additional, Salvatori, Marcus, additional, Samavedi, Satyavrata, additional, Sannino, Alessandro, additional, Scalera, Irene, additional, Sedaghati, Tina, additional, Sedrakyan, Sargis, additional, Seifalian, Alexander M., additional, Seifalian, Amelia, additional, Seliktar, Dror, additional, Selvaggi, Gennaro, additional, Shapira-Schweitzer, Keren, additional, Shinoka, Toshiharu, additional, Shupe, Thomas, additional, Smith, Nicholas R., additional, Soulillou, Jean-Paul, additional, Spinelli, Valentina, additional, Sutherland, David E.R., additional, Tara, Shuhei, additional, Teratani, Takumi, additional, Terzic, Andre, additional, Thomas, Sunu S., additional, Tisone, Giuseppe, additional, Totonelli, Giorgia, additional, Tzakis, Andreas, additional, Tzvetanov, Ivo G., additional, Udelsman, Brooks V., additional, Uygun, Basak E., additional, Vacanti, Joseph P., additional, Van Caenegem, Olivier, additional, Van Dyke, Mark, additional, Van Raemdonck, Dirk E., additional, Vorp, David A., additional, Vyas, Dipen, additional, Wang, Kun, additional, Weinbaum, Justin S., additional, Wertheim, Jason A., additional, Williams, David F., additional, Wittebole, Xavier, additional, Wong, Melissa H., additional, Wood, Kathryn J., additional, Xu, Tao, additional, Yamato, Masayuki, additional, You, Sylvaine, additional, Yuan, Yuyu, additional, Zambon, Joao Paulo, additional, Zattoni, Michela, additional, and Zhu, Lei, additional

Published
2014
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9. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

Author

Mells, George F, Floyd, James AB, Morley, Katherine I, Cordell, Heather J, Franklin, Christopher S, Shin, So-Youn, Heneghan, Michael A, Neuberger, James M, Donaldson, Peter T, Day, Darren B, Ducker, Samantha J, Muriithi, Agnes W, Wheater, Elizabeth F, Hammond, Christopher J, Dawwas, Muhammad F, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones, David E, Peltonen, Leena, Alexander, Graeme J, Sandford, Richard N, and Anderson, Carl A

Subjects
Male, Receptors, CXCR5, Death Domain Receptor Signaling Adaptor Proteins, Receptors, Interleukin-7, Monosaccharide Transport Proteins, Liver Cirrhosis, Biliary, NF-kappa B p50 Subunit, Adaptive Immunity, STAT4 Transcription Factor, Polymorphism, Single Nucleotide, Immunity, Innate, Linkage Disequilibrium, Cohort Studies, Receptors, Tumor Necrosis Factor, Type I, Risk Factors, Case-Control Studies, Databases, Genetic, B7-1 Antigen, Guanine Nucleotide Exchange Factors, Humans, Female, Genetic Predisposition to Disease, Lectins, C-Type, Genome-Wide Association Study
Abstract

In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have been identified in recent genome-wide association studies (GWAS). To identify additional loci, we carried out a GWAS using 1,840 cases from the UK PBC Consortium and 5,163 UK population controls as part of the Wellcome Trust Case Control Consortium 3 (WTCCC3). We followed up 28 loci in an additional UK cohort of 620 PBC cases and 2,514 population controls. We identified 12 new susceptibility loci (at a genome-wide significance level of P < 5 × 10⁻⁸) and replicated all previously associated loci. We identified three further new loci in a meta-analysis of data from our study and previously published GWAS results. New candidate genes include STAT4, DENND1B, CD80, IL7R, CXCR5, TNFRSF1A, CLEC16A and NFKB1. This study has considerably expanded our knowledge of the genetic architecture of PBC.

Published
2020
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11. Proximity to transplant center and outcome among liver transplant patients

Author

Webb, Gwilym J., Hodson, James, Chauhan, Abhishek, O’Grady, John, Neuberger, James M., Hirschfield, Gideon M., and Ferguson, James W.

Subjects
Adult, Male, Tissue and Organ Procurement, patient referral, Transplants, Disease-Free Survival, Health Services Accessibility, Time-to-Treatment, End Stage Liver Disease, Residence Characteristics, Risk Factors, clinical research / practice, informatics, Humans, organ transplantation in general, Registries, business / management, Geography, Medical, patient characteristics, Proportional Hazards Models, disparities, Travel, liver transplantation / hepatology, Middle Aged, Clinical Science, health services and outcomes research, Tissue Donors, United Kingdom, Liver Transplantation, Treatment Outcome, Female, Original Article, ORIGINAL ARTICLES, liver disease
Abstract

In the United States, distance from liver transplant center correlates with worsened outcomes; the effects of geography elsewhere are unassessed. We performed a national registry analysis of United Kingdom listings for liver transplantation (1995‐2014) and assessed whether travel time to transplant center correlates with outcome. There were 11 188 listings assessed (8490 transplanted), with a median travel time to center of 60 minutes (range 36‐86). Of the national population, 3.38 × 107 (55.1%) reside ≥60 minutes from a center, and 7.65 × 106 (12.5%) >119 minutes. After competing risk analysis, increasing travel time was associated with an increased risk of death after listing (subdistribution hazard ratios relative to 119 minutes; P, This analysis demonstrates worse outcomes for UK patients listed for liver transplantation who live further from a transplant center, describes the current geography of the UK transplant population, and models the optimal position for an additional center to reduce access inequality. Hanto and Ladin's editorial is on page 13.

Published
2018

18. Report of the first international liver transplantation society expert panel consensus conference on renal insufficiency in liver transplantation

Author

Charlton, Michael R., Wall, William J., Ojo, Akinlolu O., Ginés, Pere, Textor, Stephen, Shihab, Fuad S., Marotta, Paul, Cantarovich, Marcelo, Eason, James D., Wiesner, Russell H., Ramsay, Michael A., Garcia-Valdecasas, Juan C., Neuberger, James M., Feng, Sandy, Davis, Connie L., and Gonwa, Thomas A.

Published
2009
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29. Sex mismatch as a risk factor for chronic rejection of liver allografts

Author

Candinas, Daniel, Gunson, Bridget K., Nightingale, Peter, Hubscher, Stefan, McMaster, Paul, and Neuberger, James M.

Subjects
Liver -- Transplantation, Graft rejection -- Risk factors, Sex factors in disease -- Health aspects, Cytomegalovirus infections -- Health aspects
Published
1995

35. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Author

Carbone, Marco, primary, Nardi, Alessandra, additional, Flack, Steve, additional, Carpino, Guido, additional, Varvaropoulou, Nikoletta, additional, Gavrila, Caius, additional, Spicer, Ann, additional, Badrock, Jonathan, additional, Bernuzzi, Francesca, additional, Cardinale, Vincenzo, additional, Ainsworth, Holly F, additional, Heneghan, Michael A, additional, Thorburn, Douglas, additional, Bathgate, Andrew, additional, Jones, Rebecca, additional, Neuberger, James M, additional, Battezzati, Pier Maria, additional, Zuin, Massimo, additional, Taylor-Robinson, Simon, additional, Donato, Maria F, additional, Kirby, John, additional, Mitchell-Thain, Robert, additional, Floreani, Annarosa, additional, Sampaziotis, Fotios, additional, Muratori, Luigi, additional, Alvaro, Domenico, additional, Marzioni, Marco, additional, Miele, Luca, additional, Marra, Fabio, additional, Giannini, Edoardo, additional, Gaudio, Eugenio, additional, Ronca, Vincenzo, additional, Bonato, Giulia, additional, Cristoferi, Laura, additional, Malinverno, Federica, additional, Gerussi, Alessio, additional, Stocken, Deborah D, additional, Cordell, Heather J, additional, Hirschfield, Gideon M, additional, Alexander, Graeme J, additional, Sandford, Richard N, additional, Jones, David E, additional, Invernizzi, Pietro, additional, Mells, George F, additional, Thomas, Caradog, additional, Rahman, Meshbah, additional, Yapp, Tom, additional, Lye Ch'ng, Chin, additional, Harrison, Melanie, additional, Sturgess, Richard, additional, Galaska, Roman, additional, Healey, Chris, additional, Whiteman, Jessica, additional, Czaijkowski, Marek, additional, Gray, Catherine, additional, Gunasekera, Anton, additional, Gyawli, Pranab, additional, Premchand, Purushothaman, additional, Mann, Steven, additional, Elliott, Keith, additional, Kapur, Kapil, additional, Watson, Alan, additional, Foster, Graham, additional, Trembling, Paul, additional, Subhani, Javaid, additional, Harvey, Rory, additional, McCorry, Roger, additional, Adgey, Carolyn, additional, Hobson, Lucie, additional, Mulvaney-Jones, Caroline, additional, Evans, Richard, additional, Mathialahan, Thiriloganathan, additional, Ramanaden, David, additional, Gasem, Jaber, additional, Van Duyvenvoorde, Greta, additional, Shorrock, Christopher, additional, Seward, Katie, additional, Southern, Paul, additional, Tibble, Jeremy, additional, Penn, Ruth, additional, Gorard, David, additional, Maiden, Jane, additional, Damant, Rose, additional, Palegwala, Altaf, additional, Jones, Susan, additional, Alexander, Graeme, additional, Mells, George, additional, Sandford, Richard, additional, Dolwani, Sunil, additional, Prince, Martin, additional, Silvestre, Valeria, additional, Foxton, Matthew, additional, Dungca, Eleanor, additional, Mitchison, Harriet, additional, Wheatley, Natalie, additional, Gooding, Ian, additional, Doyle, Helen, additional, Karmo, Mazn, additional, Kent, Melanie, additional, Saksena, Sushma, additional, Braim, Delyth, additional, Patel, Minesh, additional, Lord, Susan, additional, Ede, Roland, additional, Paton, Alison, additional, Austin, Andrew, additional, Lancaster, Nicola, additional, Sayer, Joanna, additional, Gibbins, Andrew, additional, Hogben, Karen, additional, Hovell, Chris, additional, Fisher, Neil, additional, Carter, Martyn, additional, Koss, Konrad, additional, Musselwhite, Janine, additional, Muscariu, Florin, additional, Piotreowicz, Andrzej, additional, McKay, Alexandra, additional, Grimley, Charles, additional, Neal, David, additional, Ting Tan, Lai, additional, Lim, Guan, additional, Brighton, Jacqueline, additional, Foale, Carole, additional, Ala, Aftab, additional, Saeed, Athar, additional, Flahive, Kerry, additional, Wood, Gordon, additional, Townshend, Paula, additional, Ford, Chris, additional, Brown, Jonathan, additional, Kordula, Jean, additional, Bowles, Jane, additional, Wilkinson, Mark, additional, Palmer, Caroline, additional, Ramage, John, additional, Gordon, Harriet, additional, Featherstone, James, additional, Ridpath, Jo, additional, Ngatchu, Theodore, additional, Levi, Sass, additional, Shaukat, Syed, additional, Sadeghian, Joy, additional, Shidrawi, Ray, additional, Williams, Bronwen, additional, Abouda, George, additional, Jones, Sarah, additional, Duggan, Claire, additional, Hynes, Abigail, additional, Narain, Mark, additional, Rees, Ian, additional, Salam, Imroz, additional, Crossey, Mary, additional, Brown, Ashley, additional, MacNicol, Carolyn, additional, Williams, Simon, additional, Wilhelmsen, Elva, additional, Banim, Paul, additional, Raymode, Parizade, additional, Chilton, Andrew, additional, Das, Debasish, additional, Lee, Hye-Jeong, additional, Curtis, Howard, additional, Heneghan, Michael, additional, Gess, Markus, additional, Durant, Emma, additional, Drake, IM, additional, Bishop, Rebecca, additional, Davies, Mervyn, additional, Aldersley, Mark, additional, Ncube, Noma, additional, McNair, Alistair, additional, Srirajaskanthan, Raj, additional, Sen, Sambit, additional, Casey, Rebecca, additional, Bird, George, additional, Mendall, Mike, additional, Cowley, Caroline, additional, Barnardo, Adrian, additional, Kitchen, Paul, additional, Yoong, Kevin, additional, Amore, Kelly, additional, Sirdefield, Dawn, additional, Orpe, Jacky, additional, Mathew, Ray, additional, MacFaul, George, additional, Wrigth, Aruna, additional, Shah, Amir, additional, Evans, Chris, additional, Keggans, Janie, additional, Bird, Bridget, additional, Baxter, Gwen, additional, Saha, Subrata, additional, Pollock, Katharine, additional, Hughes, Maggie, additional, Bramley, Peter, additional, Grieve, Emma, additional, Young, Karin, additional, Fraser, Andrew, additional, Mukhopadhya, Ashis, additional, Ocker, Kate, additional, Mills, Peter, additional, Hines, Francis, additional, Shallcross, Chris, additional, Wilkins, Joy, additional, Grellier, Leonie, additional, Campbell, Stewart, additional, Martin, Kirsty, additional, Innes, Caron, additional, Shepherd, Alan, additional, Rushbrook, Simon, additional, Valliani, Talal, additional, Przemioslo, Robert, additional, Fairlamb, Helen, additional, Macdonald, Chris, additional, Eastick, Anne, additional, Metcalf, Jane, additional, Tanqueray, Elizabeth, additional, Shmueli, Udi, additional, Holbrook, Becky, additional, Davis, Andrew, additional, Browning, Julie, additional, Naqvi, Asifabbas, additional, Walker, Kirsten, additional, Lee, Tom, additional, Verheyden, Juliette, additional, Slininger, Susan, additional, Ryder, Stephen D, additional, Chapman, Roger, additional, Collier, Jane, additional, O'Donnell, Denise, additional, Stafford, Lizzie, additional, Williamson, Kate, additional, Kent, Linda, additional, Klass, Howard, additional, Ninkovic, Mary, additional, March, Linda, additional, Cramp, Matthew, additional, Simpson, Diane, additional, Dickson, Christine, additional, Sharer, Nicholas, additional, Hayes, Maria, additional, Goggin, Patrick, additional, Quinne, Mary, additional, Pearson, Sallyanne, additional, Hoeroldt, Barbara, additional, Jones, Linda, additional, Wright, Alice, additional, Booth, Jonathan, additional, Loftus, Alison, additional, Lipscomb, George, additional, Dewhurst, Hannah, additional, Gunter, Emma, additional, Williams, Earl, additional, Fouracres, Anna, additional, Farrington, Liz, additional, Graves, Lyn, additional, Hussaini, Hyder, additional, Stableforth, Bill, additional, Marriott, Suzie, additional, Ayres, Reuben, additional, Leoni, Marina, additional, Burroughs, Andrew, additional, Marshall, Eileen, additional, Tyrer, David, additional, Martin, Kate, additional, Lombard, Martin, additional, Patanwala, Imran, additional, Dali-Kemmery, Lola, additional, Lambourne, Victoria, additional, Maltby, Julia, additional, Vyas, Samir, additional, Colley, Julie, additional, Shinder, Bal, additional, Singhal, Saket, additional, Jones, Jayne, additional, Mills, Marisa, additional, Gleeson, Dermot, additional, Carnahan, Mandy, additional, Butterworth, Jeff, additional, Boulton, Kerenza, additional, Taylor, Natalie, additional, George, Keith, additional, Harding, Tim, additional, Tregonning, Julie, additional, Douglass, Andrew, additional, Brown, Carly, additional, Clifford, Gayle, additional, Panter, Simon, additional, Gocher, Denise, additional, Shearman, Jeremy, additional, Bray, Gary, additional, Hamilton, Maria, additional, Butcher, Graham, additional, Forton, Daniel, additional, Mclindon, John, additional, Curtis, Janette, additional, Das, Debashis, additional, Shewan, Tracey, additional, Cowan, Matthew, additional, Whatley, Gregory, additional, Nasseri, Mariam, additional, Grover, Bob, additional, Sivaramakrishnan, Nurani, additional, Ducker, Samantha, additional, Houghton, Kathryn, additional, Jones, David, additional, Griffiths, Laura, additional, Tripoli, Sherill, additional, Pitcher, Maxton, additional, Shpuza, Ervin, additional, White, Nikki, additional, Ghosh, Deb, additional, Douds, Andrew, additional, Green, Marie, additional, Brookes, Matthew, additional, Cumlat, Lourdes, additional, Wong, Voi Shim, additional, Warner, Karen, additional, Netherton, Kimberley, additional, Mandal, Adtya, additional, Jain, Snjiv, additional, Gupta, Hemant, additional, Sanghi, Pradeep, additional, Pereira, Steve, additional, Neuberger, James, additional, Gunson, Bridget, additional, Hirschfield, Gideon, additional, Lim, Reina Teegan, additional, Gallagher, Susan, additional, Clement, Darren, additional, Brind, Alison, additional, Watts, Gill, additional, Mupudzi, Mcdonald, additional, Wright, Mark, additional, Gitahi, Jane, additional, Gordon, Fiona, additional, Gocher, Denis, additional, Unitt, Esther, additional, Pateman, Hilary, additional, Batham, Sally, additional, Delahooke, Toby, additional, Grant, Allister, additional, Conder, Jill, additional, Higham, Andrew, additional, Cox, Mark, additional, O'Donohoe, Lynn, additional, Currie, Lynn, additional, King, Alistair, additional, Oblak, Metod, additional, Collins, Carole, additional, Whalley, Simon, additional, Quinn, Marie, additional, Baird, Yolanda, additional, Amey, Isobel, additional, Fraser, Jocelyn, additional, Li, Andy, additional, Cotterill, Donna, additional, Bell, Andrew, additional, Singhal, Amit, additional, Gee, Ian, additional, Greer, Sandra, additional, Ang, Yeng, additional, Ransford, Rupert, additional, Allison, Joanna, additional, Gotto, James, additional, Dyer, Simon, additional, Sweeting, Helen, additional, Millson, Charles, additional, Carbone, Marco, additional, Labbadia, Giancarlo, additional, Bragazzi, Maria Consiglia, additional, Andreone, Pietro, additional, Azzaroli, Francesco, additional, Galli, Andrea, additional, Tarocchi, Mirko, additional, Gasbarrini, Antonio, additional, Grieco, Antonio, additional, Marrone, Giuseppe, additional, Donato, Maria Francesca, additional, Valenti, Luca, additional, Maroni, Luca, additional, Rigamonti, Cristina, additional, and Picciotto, Antonino, additional

Published
2018
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38. Rapid dissemination of human T-lymphotropic virus type 1 during primary infection in transplant recipients

Author

Cook, Lucy B. M., Melamed, Anat, Demontis, Maria Antonietta, Laydon, Daniel J., Fox, James M., Tosswill, Jennifer H. C., de Freitas, Declan, Price, Ashley D., Medcalf, James F., Martin, Fabiola, Neuberger, James M., Bangham, Charles R. M., and Taylor, Graham P.

Subjects
2LTR DNA circles, Time Factors, Proviral load, viruses, Antibodies, Viral, Antiviral Agents, Polymerase Chain Reaction, Proviruses, immune system diseases, Virology, hemic and lymphatic diseases, Humans, Human T-lymphotropic virus 1, Transplantation, Organ transplantation, Research, virus diseases, Viral Load, HTLV-I Infections, Transplant Recipients, Raltegravir, Infectious Diseases, HTLV-1, DNA, Viral, Zidovudine, Clonality
Abstract

Background Human T-lymphotropic virus type 1 (HTLV-1) infects an estimated 10 million persons globally with transmission resulting in lifelong infection. Disease, linked to high proviral load, occurs in a minority. In established infection HTLV-1 replicates through infectious spread and clonal expansion of infected lymphocytes. Little is known about acute HTLV-1 infection. The kinetics of early HTLV-1 infection, following transplantation-acquired infection in three recipients from one HTLV-1 infected donor, is reported. The recipients were treated with two HTLV-1 enzyme inhibitors 3 weeks post exposure following the detection of HTLV-1 provirus at low level in each recipient. HTLV-1 infection was serially monitored by serology, quantification of proviral load and HTLV-1 2LTR DNA circles and by HTLV-1 unique integration site analysis. Results HTLV-1 antibodies were first detected 16–39 days post-transplantation. HTLV-1 provirus was detected by PCR on day 16–23 and increased by 2–3 log by day 38–45 with a peak proviral doubling time of 1.4 days, after which steady state was reached. The rapid proviral load expansion was associated with high frequency of HTLV-1 2LTR DNA circles. The number of HTLV-1 unique integration sites was high compared with established HTLV-1 infection. Clonal expansion of infected cells was detected as early as day 37 with high initial oligoclonality index, consistent with early mitotic proliferation. Conclusions In recipients infected through organ transplantation HTLV-1 disseminated rapidly despite early anti-HTLV-1 treatment. Proviral load set point was reached within 6 weeks. Seroconversion was not delayed. Unique integration site analysis and HTLV-1 2LTR DNA circles indicated early clonal expansion and high rate of infectious spread.

Published
2016

39. Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients

Author

Neuberger, James M., primary, Bechstein, Wolf O., additional, Kuypers, Dirk R.J., additional, Burra, Patrizia, additional, Citterio, Franco, additional, De Geest, Sabina, additional, Duvoux, Christophe, additional, Jardine, Alan G., additional, Kamar, Nassim, additional, Krämer, Bernhard K., additional, Metselaar, Herold J., additional, Nevens, Frederik, additional, Pirenne, Jacques, additional, Rodríguez-Perálvarez, Manuel L., additional, Samuel, Didier, additional, Schneeberger, Stefan, additional, Serón, Daniel, additional, Trunečka, Pavel, additional, Tisone, Giuseppe, additional, and van Gelder, Teun, additional

Published
2017
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40. Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

Author

Liu, Jimmy Z, Almarri, Mohamed A, Gaffney, Daniel J, Mells, George F, Jostins, Luke, Cordell, Heather J, Ducker, Samantha J, Day, Darren B, Heneghan, Michael A, Neuberger, James M, Donaldson, Peter T, Bathgate, Andrew J, Burroughs, Andrew, Davies, Mervyn H, Jones, David E, Alexander, Graeme J, Barrett, Jeffrey C, Sandford, Richard N, Anderson, Carl A, UK Primary Biliary Cirrhosis (PBC) Consortium, Wellcome Trust Case Control Consortium 3, Sandford, Richard [0000-0002-7437-0560], and Apollo - University of Cambridge Repository

Subjects
TYK2 Kinase, Genotype, Liver Cirrhosis, Biliary, Intracellular Signaling Peptides and Proteins, Chromosome Mapping, Proteins, Sequence Analysis, DNA, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Gene Frequency, Genetic Loci, HLA Antigens, Case-Control Studies, Humans, Regression Analysis, Genetic Predisposition to Disease, Chromosomes, Human, Pair 19, Adaptor Proteins, Signal Transducing, Genome-Wide Association Study
Abstract

We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium and 8,514 UK population controls across 196,524 variants within 186 known autoimmune risk loci. We identified 3 loci newly associated with PBC (at P0.8) with the most associated variant at the locus. We found multiple independent common, low-frequency and rare variant association signals at five loci. Of the 26 independent non-human leukocyte antigen (HLA) signals tagged on the Immunochip, 15 have SNPs in B-lymphoblastoid open chromatin regions in high LD (r2>0.8) with the most associated variant. This study shows how data from dense fine-mapping arrays coupled with functional genomic data can be used to identify candidate causal variants for functional follow-up.

Published
2012

41. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

Author

Mells, George F, Floyd, James AB, Morley, Katherine I, Cordell, Heather J, Franklin, Christopher S, Shin, So-Youn, Heneghan, Michael A, Neuberger, James M, Donaldson, Peter T, Day, Darren B, Ducker, Samantha J, Muriithi, Agnes W, Wheater, Elizabeth F, Hammond, Christopher J, Dawwas, Muhammad F, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones, David E, Peltonen, Leena, Alexander, Graeme J, Sandford, Richard N, Anderson, Carl A, Sandford, Richard [0000-0002-7437-0560], and Apollo - University of Cambridge Repository

Subjects
Male, Receptors, CXCR5, Death Domain Receptor Signaling Adaptor Proteins, Receptors, Interleukin-7, Monosaccharide Transport Proteins, Liver Cirrhosis, Biliary, NF-kappa B p50 Subunit, Adaptive Immunity, STAT4 Transcription Factor, Polymorphism, Single Nucleotide, Immunity, Innate, Linkage Disequilibrium, Cohort Studies, Receptors, Tumor Necrosis Factor, Type I, Risk Factors, Case-Control Studies, Databases, Genetic, B7-1 Antigen, Guanine Nucleotide Exchange Factors, Humans, Female, Genetic Predisposition to Disease, Lectins, C-Type, Genome-Wide Association Study
Abstract

In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have been identified in recent genome-wide association studies (GWAS). To identify additional loci, we carried out a GWAS using 1,840 cases from the UK PBC Consortium and 5,163 UK population controls as part of the Wellcome Trust Case Control Consortium 3 (WTCCC3). We followed up 28 loci in an additional UK cohort of 620 PBC cases and 2,514 population controls. We identified 12 new susceptibility loci (at a genome-wide significance level of P < 5 × 10⁻⁸) and replicated all previously associated loci. We identified three further new loci in a meta-analysis of data from our study and previously published GWAS results. New candidate genes include STAT4, DENND1B, CD80, IL7R, CXCR5, TNFRSF1A, CLEC16A and NFKB1. This study has considerably expanded our knowledge of the genetic architecture of PBC.

Published
2011

43. International comparison of liver transplant programmes: differences in indications, donor and recipient selection and outcome between Italy and UK.

Author

Carbone, Marco, Nardi, Alessandra, Marianelli, Tania, Martin, Kate, Hudson, Alex, Collett, David, Romagnoli, Renato, Pinna, Antonio, Gimson, Alexander, Neuberger, James M., and Angelico, Mario

Subjects
LIVER transplantation, ORGAN donors, DATABASES, COHORT analysis, MEDICAL care
Abstract

Background & Aims Comparing liver transplant ( LT) programmes internationally can improve outcomes by stimulating cross-national learning. Yet, comparison of crude outcomes, by using registry data, is limited by missing data, not allowing proper risk-adjustment for donor- and recipient-related factors. The objective of this study was to compare two European LT programmes based on high-quality national longitudinal databases prospectively collected in Italy and UK respectively. Methods We undertook a multicentre, international cohort study including all adults who underwent a first single organ LT in Italy ( N = 1480) and the UK ( N = 1003) between June 2007 and May 2009. Results Italian donors were much older compared to the UK ones. Hepatitis C virus infection and hepatocellular carcinoma had higher prevalence in the Italian cohort compared to the UK one (47.5% vs. 23.1%, and 47.2% vs. 17.1% respectively). Centres' volume differed significantly, with five centres out of seven in UK vs. only two out of 20 in Italy performing >60 transplants per year. No national strategies to drive the donor-recipient matching were identified in both countries. After appropriate adjustment, a higher risk of early transplant loss was identified in the Italian cohort, whereas no differences were found in the 3-year survival rates. Conclusions International comparison of LT programmes provides the opportunity for benchmarking between heterogeneous healthcare systems and should ideally become a vital part of national quality assurance programmes. This requires the implementation of a standardized methodology for data collection to appropriately weigh each country's patient case-mix and donor and recipients risk factors. [ABSTRACT FROM AUTHOR]

Published
2016
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50. The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort

Author

Pells, Greta, primary, Mells, George F., additional, Carbone, Marco, additional, Newton, Julia L., additional, Bathgate, Andrew J., additional, Burroughs, Andrew K., additional, Heneghan, Michael A., additional, Neuberger, James M., additional, Day, Darren B., additional, Ducker, Samantha J., additional, Sandford, Richard N., additional, Alexander, Graeme J., additional, and Jones, David E.J., additional

Published
2013
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