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5. Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Author

Bertrams, Wilhelm, Hönzke, Katja, Obermayer, Benedikt, Tönnies, Mario, Bauer, Torsten T., Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Stiewe, Thorsten, Nist, Andrea, Eggeling, Stephan, Suttorp, Norbert, Wolff, Thorsten, Hippenstiel, Stefan, Schmeck, Bernd, and Hocke, Andreas C.

Published
2022
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6. Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Author

Hoffmann, Karen, Obermayer, Benedikt, Hönzke, Katja, Fatykhova, Diana, Demir, Zeynep, Löwa, Anna, Alves, Luiz Gustavo Teixeira, Wyler, Emanuel, Lopez-Rodriguez, Elena, Mieth, Maren, Baumgardt, Morris, Hoppe, Judith, Firsching, Theresa C., Tönnies, Mario, Bauer, Torsten T., Eggeling, Stephan, Tran, Hong-Linh, Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Gruber, Achim D., Ochs, Matthias, Landthaler, Markus, Beule, Dieter, Suttorp, Norbert, Hippenstiel, Stefan, Hocke, Andreas C., and Kessler, Mirjana

Published
2022
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7. Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax

Author

Walker, Steven, primary, Hallifax, Robert, additional, Ricciardi, Sara, additional, Fitzgerald, Deirdre, additional, Keijzers, Marlies, additional, Lauk, Olivia, additional, Petersen, Jesper, additional, Bertolaccini, Luca, additional, Bodtger, Uffe, additional, Clive, Amelia, additional, Elia, Stefano, additional, Froudarakis, Marios, additional, Janssen, Julius, additional, Lee, Y.C. Gary, additional, Licht, Peter, additional, Massard, Gilbert, additional, Nagavci, Blin, additional, Neudecker, Jens, additional, Roessner, Eric, additional, Van Schil, Paul, additional, Waller, David, additional, Walles, Thorsten, additional, Cardillo, Giuseppe, additional, Maskell, Nick, additional, and Rahman, Najib, additional

Published
2024
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8. Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma

Author

Bischoff, Philip, Trinks, Alexandra, Obermayer, Benedikt, Pett, Jan Patrick, Wiederspahn, Jennifer, Uhlitz, Florian, Liang, Xizi, Lehmann, Annika, Jurmeister, Philipp, Elsner, Aron, Dziodzio, Tomasz, Rückert, Jens-Carsten, Neudecker, Jens, Falk, Christine, Beule, Dieter, Sers, Christine, Morkel, Markus, Horst, David, Blüthgen, Nils, and Klauschen, Frederick

Published
2021
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12. ERAS-Implementierung in der Thoraxchirurgie

Author

Neudecker, Jens, additional, Andreas, Marco Nicolas, additional, Lask, Aina, additional, Strauchmann, Julia, additional, Elsner, Aron, additional, Rückert, Jens-Carsten, additional, and Dziodzio, Tomasz, additional

Published
2024
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13. Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

Author

Lauster, Daniel, Klenk, Simon, Ludwig, Kai, Nojoumi, Saba, Behren, Sandra, Adam, Lutz, Stadtmüller, Marlena, Saenger, Sandra, Zimmler, Stephanie, Hönzke, Katja, Yao, Ling, Hoffmann, Ute, Bardua, Markus, Hamann, Alf, Witzenrath, Martin, Sander, Leif E., Wolff, Thorsten, Hocke, Andreas C., Hippenstiel, Stefan, De Carlo, Sacha, Neudecker, Jens, Osterrieder, Klaus, Budisa, Nediljko, Netz, Roland R., Böttcher, Christoph, Liese, Susanne, Herrmann, Andreas, and Hackenberger, Christian P. R.

Published
2020
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15. Next generation sequencing of lung adenocarcinoma subtypes with intestinal differentiation reveals distinct molecular signatures associated with histomorphology and therapeutic options

Author

Jurmeister, Philipp, Vollbrecht, Claudia, Behnke, Anke, Frost, Nikolaj, Arnold, Alexander, Treue, Denise, Rückert, Jens-Carsten, Neudecker, Jens, Schweizer, Leonille, Klauschen, Frederick, Horst, David, Hummel, Michael, Dietel, Manfred, and von Laffert, Maximilian

Published
2019
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16. Impact of complexity in minimally invasive liver surgery on enhanced recovery measures: prospective study

Author

Dahlke, Paul M, primary, Benzing, Christian, additional, Lurje, Georg, additional, Malinka, Thomas, additional, Raschzok, Nathanael, additional, Kamali, Can, additional, Gül-Klein, Safak, additional, Schöning, Wenzel, additional, Hillebrandt, Karl H, additional, Pratschke, Johann, additional, Neudecker, Jens, additional, and Krenzien, Felix, additional

Published
2024
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17. Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax.

Author

Walker, Steven, Hallifax, Robert, Ricciardi, Sara, Fitzgerald, Deirdre, Keijzers, Marlies, Lauk, Olivia, Petersen, Jesper, Bertolaccini, Luca, Bodtger, Uffe, Clive, Amelia, Elia, Stefano, Froudarakis, Marios, Janssen, Julius, Lee, Y C Gary, Licht, Peter, Massard, Gilbert, Nagavci, Blin, Neudecker, Jens, Roessner, Eric, and Schil, Paul Van

Subjects
EVIDENCE gaps, ADULTS, CHEST tubes, TASK forces, SURGICAL excision, PNEUMOTHORAX
Abstract

OBJECTIVES The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendations for the management of SP. METHODS This multidisciplinary Task Force addressed 12 key clinical questions on the management of pneumothorax, using ERS methodology for guideline development. Systematic searches were performed in MEDLINE and Embase. Evidence was synthesised by conducting meta-analyses, if possible, or narratively. Certainty of evidence was rated with GRADE (Grading, Recommendation, Assessment, Development and Evaluation). The Evidence to Decision framework was used to decide on the direction and strength of the recommendations. RESULTS The panel makes a conditional recommendation for conservative care of minimally symptomatic patients with primary spontaneous pneumothorax (PSP) who are clinically stable. We make a strong recommendation for needle aspiration over chest tube drain for initial PSP treatment. We make a conditional recommendation for ambulatory management for initial PSP treatment. We make a conditional recommendation for early surgical intervention for the initial treatment of PSP in patients who prioritise recurrence prevention. The panel makes a conditional recommendation for autologous blood patch in secondary SP patients with persistent air leak (PAL). The panel could not make recommendations for other interventions, including bronchial valves, suction, pleurodesis in addition to surgical resection or type of surgical pleurodesis. CONCLUSIONS With this international guideline, the ERS, EACTS and ESTS societies provide clinical practice recommendations for SP management. We highlight evidence gaps for the management of PAL and recurrence prevention, with research recommendations made. Shareable Abstract This update of an ERS Task Force statement from 2015 provides a concise comprehensive update of the literature base. 24 evidence-based recommendations were made for management of pneumothorax, balancing clinical priorities and patient views. https://bit.ly/3TKGp9e [ABSTRACT FROM AUTHOR]

Published
2024
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18. Local ablative treatment for synchronous single organ oligometastatic lung cancer—A propensity score analysis of 180 patients

Author

Frost, Nikolaj, Tessmer, Antje, Schmittel, Alexander, van Laak, Vincent, Raspe, Matthias, Ruwwe-Glösenkamp, Christoph, Brunn, Matthias, Senger, Carolin, Böhmer, Dirk, Ochsenreither, Sebastian, Temmesfeld-Wollbrück, Bettina, Furth, Christian, Schmidt, Bernd, Neudecker, Jens, Rückert, Jens-Carsten, Suttorp, Norbert, Witzenrath, Martin, and Grohé, Christian

Published
2018
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19. Primary Open Versus Closed Implantation Strategy for Totally Implantable Venous Access Ports: The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900)

Author

Hüttner, Felix J., Bruckner, Tom, Hackbusch, Matthes, Weitz, Jürgen, Bork, Ulrich, Kotschenreuther, Peter, Heupel, Oliver, Kümmel, Sabine, Schlitt, Hans J., Mattulat, Matthias, Pintér, László, Seiler, Christoph M., Gutt, Carsten N., Nottberg, Hubertus S., Pohl, Alexander, Ghanem, Firas, Meyer, Thomas, Imdahl, Andreas, Neudecker, Jens, Müller, Verena A., Gehrig, Tobias, Reineke, Mario, von Frankenberg, Moritz, Schumacher, Guido, Hennes, Roland, Mihaljevic, André L., Rossion, Inga, Klose, Christina, Kieser, Meinhard, Büchler, Markus W., Diener, Markus K., and Knebel, Phillip

Published
2020
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20. Encouraging student-driven clinical research in Germany: the CHIR-Net SIGMA network

Author

Frey Pia-Elena, Friedrich Mirco, Rädeker Lukas, Fink Christoph A., Leuck Alexander, Tenckhoff Solveig, Neudecker Jens, and Mihaljevic André L.

Subjects
chir-net, clinical trial, evidence-based medicine, medical education, patronus, research personnel, sigma, Surgery, RD1-811
Abstract

Evidence should define and guide modern clinical care, yet many relevant questions in surgical practice remain unconfirmed by substantial data. Evidence-based medicine requires both the implementation of its principles in day-to-day work and the acquisition of new evidence preferably by randomized controlled trials and systematic reviews. Meaningful clinical research, however, is challenging to conduct, and its overall infrastructure in Germany was, until recently, considered poor compared to other leading countries. Although this has been significantly improved after the establishment of the Study Center of the German Surgical Society (SDGC) and the surgical clinical trial network CHIR-Net, limited focus has been put on the training, teaching, and recruitment of medical students to become competent clinical researchers and clinician scientists. To ensure continuing comprehensive clinical research in surgery, CHIR-Net aims to establish a student-driven multicenter research network in Germany, which is embedded in both the national CHIR-Net and the pan-European and international frameworks. Student-Initiated German Medical Audits (SIGMA) is a product of the strong collaboration between clinical scientists and medical trainees, enabling students to contribute to high-quality clinical trials. Additionally, participants are offered extensive training to support the next generation of research-active clinicians. Starting on 2018, SIGMA will perform its first multicenter observational study in Germany.

Published
2017
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21. Do skip-N2 metastases significantly impact overall survival and disease-free interval in N2 non-small-cell lung cancer patients? A multicentre analysis

Author

Schlachtenberger, Georg, primary, Schallenberg, Simon, additional, Doerr, Fabian, additional, Menghesha, Hruy, additional, Gaisendrees, Christopher, additional, Amorin, Andres, additional, Grathwohl, Corinna, additional, Büttner, Reinhard, additional, Quaas, Alexander, additional, Horst, David, additional, Klauschen, Frederick, additional, Frost, Nikolaj, additional, Rueckert, Jens-C, additional, Neudecker, Jens, additional, Höpker, Katja, additional, Wahlers, Thorsten, additional, Hekmat, Khosro, additional, and Heldwein, Matthias B, additional

Published
2023
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24. Validation of the Enhanced Recovery after Surgery (ERAS) society recommendations for liver surgery: a prospective, observational study

Author

Schmelzle, Moritz, primary, Krenzien, Felix, additional, Dahlke, Paul, additional, Krombholz, Alina, additional, Nevermann, Nora, additional, Feldbrügge, Linda, additional, Winter, Axel, additional, Schöning, Wenzel, additional, Benzing, Christian, additional, Pratschke, Johann, additional, and Neudecker, Jens, additional

Published
2023
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29. Effectiveness of triclosan-coated PDS Plus versus uncoated PDS II sutures for prevention of surgical site infection after abdominal wall closure: the randomised controlled PROUD trial

Author

Diener, Markus K, Knebel, Phillip, Kieser, Meinhard, Schüler, Philipp, Schiergens, Tobias S, Atanassov, Vladimir, Neudecker, Jens, Stein, Erwin, Thielemann, Henryk, Kunz, Reiner, von Frankenberg, Moritz, Schernikau, Utz, Bunse, Jörg, Jansen-Winkeln, Boris, Partecke, Lars I, Prechtl, Gerald, Pochhammer, Julius, Bouchard, Ralf, Hodina, René, Beckurts, K Tobias E, Leißner, Lothar, Lemmens, Hans-Peter, Kallinowski, Friedrich, Thomusch, Oliver, Seehofer, Daniel, Simon, Thomas, Hyhlik-Dürr, Alexander, Seiler, Christoph M, Hackert, Thilo, Reissfelder, Christoph, Hennig, René, Doerr-Harim, Colette, Klose, Christina, Ulrich, Alexis, and Büchler, Markus W

Published
2014
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30. Prospective multicentre cohort study of patient-reported outcomes and complications following major abdominal neoplastic surgery (PATRONUS) – study protocol for a CHIR-Net student-initiated German medical audit study (CHIR-Net SIGMA study)

Author

Fink, Christoph A., Friedrich, Mirco, Frey, Pia-Elena, Rädeker, Lukas, Leuck, Alexander, Bruckner, Thomas, Feisst, Manuel, Tenckhoff, Solveig, Klose, Christina, Dörr-Harim, Colette, Neudecker, Jens, and Mihaljevic, André L.

Published
2018
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31. The EAES Clinical Practice Guidelines on the Pneumoperitoneum for Laparoscopic Surgery (2002)

Author

Neudecker, Jens, Sauerland, Stefan, Neugebauer, Edmund A.M., Bergamaschi, Roberto, Bonjer, H.Jaap, Cuschieri, Alfred, Fuchs, Karl-Hermann, Jacobi, Christoph A., Jansen, F.W., Koivusalo, A.-M., Lacy, Antonio M., McMahon, M.J., Millat, Bertrand, Schwenk, Wolfgang, Neugebauer, E.A.M., editor, Sauerland, S., editor, Fingerhut, A., editor, Millat, B., editor, and Buess, G., editor

Published
2006
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32. Reply to Fujino et al

Author

Hocke, Andreas C., Berg, Johanna, Becher, Anne, Knepper, Jessica, Klauschen, Frederick, Tönnies, Mario, Bauer, Torsten T., Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Gruber, Achim D., Suttorp, Norbert, Hippenstiel, Stefan, and Wolff, Thorsten

Published
2013
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34. A machine learning tool to improve prediction of mediastinal lymph node metastases in non-small cell lung cancer using routinely obtainable [18F]FDG-PET/CT parameters.

Author

Rogasch, Julian M. M., Michaels, Liza, Baumgärtner, Georg L., Frost, Nikolaj, Rückert, Jens-Carsten, Neudecker, Jens, Ochsenreither, Sebastian, Gerhold, Manuela, Schmidt, Bernd, Schneider, Paul, Amthauer, Holger, Furth, Christian, and Penzkofer, Tobias

Subjects
NON-small-cell lung carcinoma, LYMPHATIC metastasis, MACHINE tools, FEATURE selection, MACHINE learning, POSITRON emission tomography
Abstract

Background: In patients with non-small cell lung cancer (NSCLC), accuracy of [18F]FDG-PET/CT for pretherapeutic lymph node (LN) staging is limited by false positive findings. Our aim was to evaluate machine learning with routinely obtainable variables to improve accuracy over standard visual image assessment. Methods: Monocentric retrospective analysis of pretherapeutic [18F]FDG-PET/CT in 491 consecutive patients with NSCLC using an analog PET/CT scanner (training + test cohort, n = 385) or digital scanner (validation, n = 106). Forty clinical variables, tumor characteristics, and image variables (e.g., primary tumor and LN SUVmax and size) were collected. Different combinations of machine learning methods for feature selection and classification of N0/1 vs. N2/3 disease were compared. Ten-fold nested cross-validation was used to derive the mean area under the ROC curve of the ten test folds ("test AUC") and AUC in the validation cohort. Reference standard was the final N stage from interdisciplinary consensus (histological results for N2/3 LNs in 96%). Results: N2/3 disease was present in 190 patients (39%; training + test, 37%; validation, 46%; p = 0.09). A gradient boosting classifier (GBM) with 10 features was selected as the final model based on test AUC of 0.91 (95% confidence interval, 0.87–0.94). Validation AUC was 0.94 (0.89–0.98). At a target sensitivity of approx. 90%, test/validation accuracy of the GBM was 0.78/0.87. This was significantly higher than the accuracy based on "mediastinal LN uptake > mediastinum" (0.7/0.75; each p < 0.05) or combined PET/CT criteria (PET positive and/or LN short axis diameter > 10 mm; 0.68/0.75; each p < 0.001). Harmonization of PET images between the two scanners affected SUVmax and visual assessment of the LNs but did not diminish the AUC of the GBM. Conclusions: A machine learning model based on routinely available variables from [18F]FDG-PET/CT improved accuracy in mediastinal LN staging compared to established visual assessment criteria. A web application implementing this model was made available. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Influenza A Viruses Target Type II Pneumocytes in the Human Lung

Author

Weinheimer, Viola K., Becher, Anne, Tönnies, Mario, Holland, Gudrun, Knepper, Jessica, Bauer, Torsten T., Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Szymanski, Kolja, Temmesfeld-Wollbrueck, Bettina, Gruber, Achim D., Bannert, Norbert, Suttorp, Norbert, Hippenstiel, Stefan, Wolff, Thorsten, and Hocke, Andreas C.

Published
2012
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36. Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

Author

Hönzke, Katja, primary, Obermayer, Benedikt, additional, Mache, Christin, additional, Fatykhova, Diana, additional, Kessler, Mirjana, additional, Dökel, Simon, additional, Wyler, Emanuel, additional, Baumgardt, Morris, additional, Löwa, Anna, additional, Hoffmann, Karen, additional, Graff, Patrick, additional, Schulze, Jessica, additional, Mieth, Maren, additional, Hellwig, Katharina, additional, Demir, Zeynep, additional, Biere, Barbara, additional, Brunotte, Linda, additional, Mecate-Zambrano, Angeles, additional, Bushe, Judith, additional, Dohmen, Melanie, additional, Hinze, Christian, additional, Elezkurtaj, Sefer, additional, Tönnies, Mario, additional, Bauer, Torsten T., additional, Eggeling, Stephan, additional, Tran, Hong-Linh, additional, Schneider, Paul, additional, Neudecker, Jens, additional, Rückert, Jens C., additional, Schmidt-Ott, Kai M., additional, Busch, Jonas, additional, Klauschen, Frederick, additional, Horst, David, additional, Radbruch, Helena, additional, Radke, Josefine, additional, Heppner, Frank, additional, Corman, Victor M., additional, Niemeyer, Daniela, additional, Müller, Marcel A., additional, Goffinet, Christine, additional, Mothes, Ronja, additional, Pascual-Reguant, Anna, additional, Hauser, Anja Erika, additional, Beule, Dieter, additional, Landthaler, Markus, additional, Ludwig, Stephan, additional, Suttorp, Norbert, additional, Witzenrath, Martin, additional, Gruber, Achim D., additional, Drosten, Christian, additional, Sander, Leif-Erik, additional, Wolff, Thorsten, additional, Hippenstiel, Stefan, additional, and Hocke, Andreas C., additional

Published
2022
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37. Reducing Immunosuppression in Patients with De Novo Lung Carcinoma after Liver Transplantation Could Significantly Prolong Survival

Author

Pesthy, Sina, primary, Wegener, Elisa, additional, Ossami Saidy, Ramin Raul, additional, Timmermann, Lea, additional, Uluk, Deniz, additional, Aydin, Mustafa, additional, Dziodzio, Tomasz, additional, Schoening, Wenzel, additional, Lurje, Georg, additional, Öllinger, Robert, additional, Frost, Nikolaj, additional, Fehrenbach, Uli, additional, Rückert, Jens-Carsten, additional, Neudecker, Jens, additional, Pratschke, Johann, additional, and Eurich, Dennis, additional

Published
2022
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38. Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial

Author

Diener, Markus K, Seiler, Christoph M, Rossion, Inga, Kleeff, Jörg, Glanemann, Matthias, Butturini, Giovanni, Tomazic, Ales, Bruns, Christiane J, Busch, Olivier RC, Farkas, Stefan, Belyaev, Orlin, Neoptolemos, John P, Halloran, Christopher, Keck, Tobias, Niedergethmann, Marco, Gellert, Klaus, Witzigmann, Helmut, Kollmar, Otto, Langer, Peter, Steger, Ulrich, Neudecker, Jens, Berrevoet, Frederik, Ganzera, Silke, Heiss, Markus M, Luntz, Steffen P, Bruckner, Thomas, Kieser, Meinhard, and Büchler, Markus W

Published
2011
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40. The single‐cell transcriptional landscape of lung carcinoid tumors

Author

Bischoff, Philip, primary, Trinks, Alexandra, additional, Wiederspahn, Jennifer, additional, Obermayer, Benedikt, additional, Pett, Jan Patrick, additional, Jurmeister, Philipp, additional, Elsner, Aron, additional, Dziodzio, Tomasz, additional, Rückert, Jens‐Carsten, additional, Neudecker, Jens, additional, Falk, Christine, additional, Beule, Dieter, additional, Sers, Christine, additional, Morkel, Markus, additional, Horst, David, additional, Klauschen, Frederick, additional, and Blüthgen, Nils, additional

Published
2022
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42. Reducing Immunosuppression in Patients with De Novo Lung Carcinoma after Liver Transplantation Could Significantly Prolong Survival

Author

Pesthy, Sina, Wegener, Elisa, Ossami Saidy, Ramin Raul, Timmermann, Lea, Uluk, Deniz, Aydin, Mustafa, Dziodzio, Tomasz, Schoening, Wenzel, Lurje, Georg, Öllinger, Robert, Frost, Nikolaj, Fehrenbach, Uli, Rückert, Jens-Carsten, Neudecker, Jens, Pratschke, Johann, and Eurich, Dennis

Subjects
immunosuppression, liver transplantation, de novo lung cancer, lung carcinoma, surgical tumor resection, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Simple Summary: Long-term immunosuppressive therapy following liver transplantation is associated with an increased risk for the development of de novo lung carcinoma. However, data on the management of the immunosuppression following the diagnosis of lung cancer are missing to the present day. In this retrospective analysis, we investigate factors associated with improved survival of liver transplant recipients with diagnosis of de novo lung carcinoma with a particular emphasis on the impact of immunosuppression. Our findings suggest that strict reduction of immunosuppression has a beneficial effect on survival in this particular situation and, thus, should be an early intervention following diagnosis. Liver transplant recipients with the diagnosis of de novo lung cancer should be offered surgical treatment if technically feasible as a potential curative therapeutic option to improve limited prognosis. Further investigations concerning dosage findings and reduction of immunosuppression in organ recipients should be the targets of subsequent studies. Abstract: (1) Background: Liver transplantation (LT) is an established treatment for selected patients with end-stage liver disease resulting in a subsequent need for long-term immunosuppressive therapy. With cumulative exposure to immunosuppression (IS), the risk for the development of de novo lung carcinoma increases. Due to limited therapy options and prognosis after diagnosis of lung cancer, the question of the mode and extent of IS in this particular situation is raised. (2) Methods: All patients diagnosed with de novo lung cancer in the follow-up after LT were identified from the institution's register of liver allograft recipients (Charite-Universitatsmedizin Berlin, Germany) transplanted between 1988 and 2021. Survival analysis was performed based on the IS therapy following diagnosis of lung cancer and the oncological treatment approach. (3) Results: Among 3207 adult LTs performed in 2644 patients at our institution, 62 patients (2.3%) developed de novo lung carcinoma following LT. Lung cancer was diagnosed at a median interval of 9.7 years after LT (range 0.7-27.0 years). Median survival after diagnosis of lung carcinoma was 13.2 months (range 0-196 months). Surgical approach with curative intent significantly prolonged survival rates compared to palliative treatment (median 67.4 months vs. 6.4 months). Reduction of IS facilitated a significant improvement in survival (median 38.6 months vs. 6.7 months). In six patients (9.7%) complete IS weaning was achieved with unimpaired liver allograft function. (4) Conclusion: Reduction of IS therapy after the diagnosis of de novo lung cancer in LT patients is associated with prolonged survival. The risk of acute rejection does not appear to be increased with restrictive IS management. Therefore, strict reduction of IS should be an early intervention following diagnosis. In addition, surgical resection should be attempted, if technically feasible and oncologically meaningful.

Published
2022
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43. Preclinical Assessment of Bacteriophage Therapy against Experimental Lung Infection

Author

Wienhold, Sandra-Maria, Brack, Markus C, Nouailles, Geraldine, Krishnamoorthy, Gopinath, Korf, Imke H E, Seitz, Claudius, Wienecke, Sarah, Dietert, Kristina, Gurtner, Corinne, Kershaw, Olivia, Gruber, Achim D, Ross, Anton, Ziehr, Holger, Rohde, Manfred, Neudecker, Jens, Lienau, Jasmin, Suttorp, Norbert, Hippenstiel, Stefan, Hocke, Andreas C, Rohde, Christine, Witzenrath, Martin, and HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.

Subjects
Acinetobacter baumannii, antibiotic resistance, bacteriophage, pneumonia, preclinical development
Abstract

Respiratory infections caused by multidrug-resistant Acinetobacter baumannii are difficult to treat and associated with high mortality among critically ill hospitalized patients. Bacteriophages (phages) eliminate pathogens with high host specificity and efficacy. However, the lack of appropriate preclinical experimental models hampers the progress of clinical development of phages as therapeutic agents. Therefore, we tested the efficacy of a purified lytic phage, vB_AbaM_Acibel004, against multidrug-resistant A. baumannii clinical isolate RUH 2037 infection in immunocompetent mice and a human lung tissue model. Sham- and A. baumannii-infected mice received a single-dose of phage or buffer via intratracheal aerosolization. Group-specific differences in bacterial burden, immune and clinical responses were compared. Phage-treated mice not only recovered faster from infection-associated hypothermia but also had lower pulmonary bacterial burden, lower lung permeability, and cytokine release. Histopathological examination revealed less inflammation with unaffected inflammatory cellular recruitment. No phage-specific adverse events were noted. Additionally, the bactericidal effect of the purified phage on A. baumannii was confirmed after single-dose treatment in an ex vivo human lung infection model. Taken together, our data suggest that the investigated phage has significant potential to treat multidrug-resistant A. baumannii infections and further support the development of appropriate methods for preclinical evaluation of antibacterial efficacy of phages.

Published
2021

44. Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection

Author

Wienhold, Sandra-Maria, primary, Brack, Markus C., additional, Nouailles, Geraldine, additional, Krishnamoorthy, Gopinath, additional, Korf, Imke H. E., additional, Seitz, Claudius, additional, Wienecke, Sarah, additional, Dietert, Kristina, additional, Gurtner, Corinne, additional, Kershaw, Olivia, additional, Gruber, Achim D., additional, Ross, Anton, additional, Ziehr, Holger, additional, Rohde, Manfred, additional, Neudecker, Jens, additional, Lienau, Jasmin, additional, Suttorp, Norbert, additional, Hippenstiel, Stefan, additional, Hocke, Andreas C., additional, Rohde, Christine, additional, and Witzenrath, Martin, additional

Published
2021
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45. The single-cell transcriptional landscape of lung carcinoid tumors

Author

Bischoff, Philip, primary, Trinks, Alexandra, additional, Wiederspahn, Jennifer, additional, Obermayer, Benedikt, additional, Pett, Jan Patrick, additional, Jurmeister, Philipp, additional, Elsner, Aron, additional, Dziodzio, Tomasz, additional, Rückert, Jens-Carsten, additional, Neudecker, Jens, additional, Falk, Christine, additional, Beule, Dieter, additional, Sers, Christine, additional, Morkel, Markus, additional, Horst, David, additional, Klauschen, Frederick, additional, and Blüthgen, Nils, additional

Published
2021
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46. Thoracic Surgery in the COVID-19 Pandemic: A Novel Approach to Reach Guideline Consensus

Author

Dziodzio, Tomasz, Knitter, Sebastian, Wu, Helen Hairun, Ritschl, Paul Viktor, Hillebrandt, Karl-Herbert, Jara, Maximilian, Juraszek, Andrzej, Öllinger, Robert, Pratschke, Johann, Rückert, Jens, and Neudecker, Jens

Subjects
SARS-CoV-2, recommendations, Medicine, COVID-19, guidelines, thoracic surgery, Article, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

The COVID-19 pandemic challenges international and national healthcare systems. In the field of thoracic surgery, procedures may be deferred due to mandatory constraints of the access to diagnostics, staff and follow-up facilities. There is a lack of prospective data on the management of benign and malignant thoracic conditions in the pandemic. Therefore, we derived recommendations from 14 thoracic societies to address key questions on the topic of COVID-19 in the field of thoracic surgery. Respective recommendations were extracted and the degree of consensus among different organizations was calculated. A high degree of consensus was found to temporarily suspend non-critical elective procedures or procedures for benign conditions and to prioritize patients with symptomatic or advanced cancer. Prior to hospitalization, patients should be screened for respiratory symptoms indicating possible COVID-19 infection and most societies recommended to screen all patients for COVID-19 prior to admission. There was a weak consensus on the usage of serology tests and CT scans for COVID-19 diagnostics. Nearly all societies suggested to postpone elective procedures in patients with suspected or confirmed COVID-19 and recommended constant reevaluation of these patients. Additionally, we summarized recommendations focusing on precautions in the theater and the management of chest drains. This study provides a novel approach to informed guidance for thoracic surgeons during the COVID-19 pandemic in the absence of scientific evidence-based data.

Published
2021
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