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Your search keyword '"Neuroendocrine liver metastasi"' showing total 3 results
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3 results on '"Neuroendocrine liver metastasi"'

1. Liver Resection for Neuroendocrine Tumor Liver Metastases Within Milan Criteria for Liver Transplantation

Author

Giorgio Ercolani, Nadia Russolillo, Luca Aldrighetti, Guido Torzilli, Alfredo Guglielmi, Agostino Maria De Rose, Francesca Bertuzzo, Andrea Ruzzenente, Francesca Ratti, Alessandro Cucchetti, Simone Conci, Alessandro Ferrero, Pasquale Perri, Gian Luca Grazi, Matteo Cimino, Andrea Dore, Tommaso Campagnaro, Calogero Iacono, Fabio Bagante, Felice Giuliante, Ruzzenente, Andrea, Bagante, Fabio, Bertuzzo, Francesca, Aldrighetti, Luca, Campagnaro, Tommaso, Ercolani, Giorgio, Conci, Simone, Giuliante, Felice, Dore, Andrea, Ferrero, Alessandro, Torzilli, Guido, Grazi, Gian Luca, Ratti, Francesca, Cucchetti, Alessandro, De Rose, Agostino M., Russolillo, Nadia, Cimino, Matteo, Perri, Pasquale, Guglielmi, Alfredo, Iacono, Calogero, Ruzzenente, A, Bagante, F, Bertuzzo, F, Aldrighetti, L, Campagnaro, T, Ercolani, G, Conci, S, Giuliante, F, Dore, A, Ferrero, A, Torzilli, G, Grazi, Gl, Ratti, F, Cucchetti, A, De Rose, Am, Russolillo, N, Cimino, M, Perri, P, Guglielmi, A, and Iacono, C

Subjects
Male, medicine.medical_specialty, Neuroendocrine liver metastasi, Liver volume, medicine.medical_treatment, Milan criteria, Liver transplantation, Gastroenterology, NO, Resection, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, Hepatectomy, Humans, Liver surgery, Neuroendocrine liver metastasis, Liver transplant, Liver surgery, Liver transplant, Neuroendocrine liver metastasis, Surgery, Gastroenterology, LS7_4, Aged, Tumor size, business.industry, Patient Selection, Liver Neoplasms, TUMOR LIVER, Middle Aged, medicine.disease, Liver Transplantation, Tumor Burden, Survival Rate, Neuroendocrine Tumors, 030220 oncology & carcinogenesis, Cohort, Practice Guidelines as Topic, 030211 gastroenterology & hepatology, Surgery, Female, business
Abstract

Background: The role of liver transplant (LT) for neuroendocrine liver metastasis (NELM) has not been completely defined. While international guidelines included LT as a potential treatment for highly selected patients with advanced NELM, recently, LT has been proposed as an alternative curative treatment for NELM for patients meeting restrictive criteria (Milan criteria). Methods: Using a multi-institutional cohort of patients undergoing liver resection for NELM, the long-term outcomes of patients meeting Milan criteria (resected NET drained by the portal system, stable disease/response to therapies for at least 6 months, metastatic diffusion to < 50% of the total liver volume, a confirmed histology of low-grade, and ≤ 60 years) were investigated. Results: Among the 238 patients included in the study, 28 (12%) patients met the Milan criteria for LT with a 5-year OS of 83%. Furthermore, among patients meeting Milan criteria, subsets of patients with favorable clinic-pathological characteristics had 5-year OS rates greater than 90% including G1 patients (5-year OS, 92%), patients undergoing minor liver resection (5-year OS, 94%), patients with low number of NELM (1–2 NELM), and small tumor size (< 3 cm) (for both groups of patients, 5-year OS, 100%). Conclusions: In our series, only 12% of patients met Milan criteria, and the 5-year OS after liver resection for this small selected group of patients was comparable with that reported in the literature for patients undergoing LT for NELM within Milan criteria. While LT might be the optimal treatment for patients with unresectable NELM, surgical resection should be the first option for patients with resectable NELM.

Published
2018

2. A Novel Nomogram to Predict the Prognosis of Patients Undergoing Liver Resection for Neuroendocrine Liver Metastasis: an Analysis of the Italian Neuroendocrine Liver Metastasis Database

Author

Ruzzenente, Andrea, Bagante, Fabio, Bertuzzo, Francesca, Aldrighetti, Luca, Ercolani, Giorgio, Giuliante, Felice, Ferrero, Alessandro, Torzilli, Guido, Grazi, Gian Luca, Ratti, Francesca, Cucchetti, Alessandro, De Rose, Agostino Maria, Russolillo, Nadia, Cimino, Matteo, Perri, Pasquale, Cataldo, Ivana, Scarpa, Aldo, Guglielmi, Alfredo, Iacono, Calogero, Giuliante, Felice (ORCID:0000-0001-9517-8220), Ruzzenente, Andrea, Bagante, Fabio, Bertuzzo, Francesca, Aldrighetti, Luca, Ercolani, Giorgio, Giuliante, Felice, Ferrero, Alessandro, Torzilli, Guido, Grazi, Gian Luca, Ratti, Francesca, Cucchetti, Alessandro, De Rose, Agostino Maria, Russolillo, Nadia, Cimino, Matteo, Perri, Pasquale, Cataldo, Ivana, Scarpa, Aldo, Guglielmi, Alfredo, Iacono, Calogero, and Giuliante, Felice (ORCID:0000-0001-9517-8220)

Abstract

Even though surgery remains the only potentially curative option for patients with neuroendocrine liver metastases, the factors determining a patient’s prognosis following hepatectomy are poorly understood. Using a multicentric database including patients who underwent hepatectomy for NELMs at seven tertiary referral hepato-biliary-pancreatic centers between January 1990 and December 2014, we sought to identify the predictors of survival and develop a clinical tool to predict patient’s prognosis after liver resection for NELMs. The median age of the 238 patients included in the study was 61.9 years (interquartile range 51.5–70.1) and 55.9 % (n = 133) of patients were men. The number of NELMs (hazard ratio = 1.05), tumor size (HR = 1.01), and Ki-67 index (HR = 1.07) were the predictors of overall survival. These variables were used to develop a nomogram able to predict survival. According to the predicted 5-year OS, patients were divided into three different risk classes: 19.3, 55.5, and 25.2 % of patients were in low (>80 % predicted 5-year OS), medium (40–80 % predicted 5-year OS), and high (<40 % predicted 5-year OS) risk classes. The 10-year OS was 97.0, 55.9, and 20.0 % in the low, medium, and high-risk classes, respectively (p < 0.001). We developed a novel nomogram that accurately (c-index >70 %) staged and predicted the prognosis of patients undergoing liver resection for NELMs.

Published
2017

3. A Novel Nomogram to Predict the Prognosis of Patients Undergoing Liver Resection for Neuroendocrine Liver Metastasis: an Analysis of the Italian Neuroendocrine Liver Metastasis Database

Author

Andrea Ruzzenente, Guido Torzilli, Francesca Bertuzzo, Agostino Maria De Rose, Nadia Russolillo, Calogero Iacono, Francesca Ratti, Matteo Cimino, Luca Aldrighetti, Pasquale Perri, Gian Luca Grazi, Giorgio Ercolani, Alfredo Guglielmi, Felice Giuliante, Aldo Scarpa, Fabio Bagante, Ivana Cataldo, Alessandro Ferrero, Alessandro Cucchetti, Ruzzenente, A, Bagante, F, Bertuzzo, F, Aldrighetti, L, Ercolani, G, Giuliante, F, Ferrero, A, Torzilli, G, Grazi, G, Ratti, F, Cucchetti, A, De Rose, Am, Russolillo, N, Cimino, M, Perri, P, Cataldo, I, Scarpa, A, Guglielmi, A, Iacono, C, Ruzzenente, Andrea, Bagante, Fabio, Bertuzzo, Francesca, Aldrighetti, Luca, Ercolani, Giorgio, Giuliante, Felice, Ferrero, Alessandro, Torzilli, Guido, Grazi, Gian Luca, Ratti, Francesca, Cucchetti, Alessandro, de Rose, Agostino M., Russolillo, Nadia, Cimino, Matteo, Perri, Pasquale, Cataldo, Ivana, Scarpa, Aldo, Guglielmi, Alfredo, and Iacono, Calogero

Subjects
Male, Databases, Factual, Settore MED/18 - CHIRURGIA GENERALE, medicine.medical_treatment, Neuroendocrine liver metastasi, Liver surgery, Neuroendocrine liver metastasis, Prognostic model, Surgery, Gastroenterology, 030230 surgery, computer.software_genre, Risk Assessment, NO, Metastasis, Resection, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Overall survival, Medicine, Hepatectomy, Humans, LS7_4, Aged, Database, Tumor size, business.industry, Medicine (all), Hazard ratio, Liver Neoplasms, Nomogram, Middle Aged, medicine.disease, Prognosis, Neuroendocrine Tumors, Nomograms, Italy, 030220 oncology & carcinogenesis, Female, business, computer
Abstract

Even though surgery remains the only potentially curative option for patients with neuroendocrine liver metastases, the factors determining a patient's prognosis following hepatectomy are poorly understood. Using a multicentric database including patients who underwent hepatectomy for NELMs at seven tertiary referral hepato-biliary-pancreatic centers between January 1990 and December 2014, we sought to identify the predictors of survival and develop a clinical tool to predict patient's prognosis after liver resection for NELMs. The median age of the 238 patients included in the study was 61.9 years (interquartile range 51.5-70.1) and 55.9 % (n = 133) of patients were men. The number of NELMs (hazard ratio = 1.05), tumor size (HR = 1.01), and Ki-67 index (HR = 1.07) were the predictors of overall survival. These variables were used to develop a nomogram able to predict survival. According to the predicted 5-year OS, patients were divided into three different risk classes: 19.3, 55.5, and 25.2 % of patients were in low (> 80 % predicted 5-year OS), medium (40-80 % predicted 5-year OS), and high (< 40 % predicted 5-year OS) risk classes. The 10-year OS was 97.0, 55.9, and 20.0 % in the low, medium, and high-risk classes, respectively (p < 0.001). We developed a novel nomogram that accurately (c-index > 70 %) staged and predicted the prognosis of patients undergoing liver resection for NELMs.

Published
2016

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