1. Molar activity - The keystone in
- Author
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Verena, Pichler, Thomas, Zenz, Cécile, Philippe, Chrysoula, Vraka, Neydher, Berrotéran-Infante, Sarah, Pfaff, Lukas, Nics, Marius, Ozenil, Oliver, Langer, Matthäus, Willeit, Tatjana, Traub-Weidinger, Rupert, Lanzenberger, Markus, Mitterhauser, Marcus, Hacker, and Wolfgang, Wadsak
- Subjects
Radiochemistry ,Positron-Emission Tomography ,Carbon Radioisotopes ,Gases ,Radioactive Tracers - Abstract
Radiochemists/radiopharmacists, involved in the preparation of radiopharmaceuticals are regularly confronted with the requirement of continuous high quality productions in their day-to-day business. One of these requirements is high specific or molar activity of the radiotracer in order to avoid e.g. receptor saturation and pharmacological or even toxic effects of the applied tracer for positron emission tomography. In the case ofIn this study, diverseThe manifold contributions to low molar activity can be attributed to three main categories, namely technical parameters (e.g. quality of target gases, reagents or tubings), inter/intralaboratory parameters (e.g. maintenance interval, burden of the module, etc.) and interoperator parameters (e.g. handling of the module).Our study provides a better understanding of different factors contributing to the overall carbon load of a synthesis module, which facilitates maintenance of high molar activity of carbon-11-labeled radiopharmaceuticals.
- Published
- 2018