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2. Prospects for $\gamma$-ray observations of the Perseus galaxy cluster with the Cherenkov Telescope Array

Author

Consortium, The Cherenkov Telescope Array, Abe, K., Abe, S., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Angüner, E. O., Antonelli, L. A., Aramo, C., Araya, M., Arcaro, C., Arrabito, L., Asano, K., Ascasíbar, Y., Aschersleben, J., Ashkar, H., Stuani, L. Augusto, Baack, D., Backes, M., Baktash, A., Balazs, C., Balbo, M., Ballester, O., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batista, P. I., Batkovic, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Tjus, J. Becker, Benbow, W., Medrano, J. Bernete, Bernlöhr, K., Berti, A., Bertucci, B., Beshley, V., Bhattacharjee, P., Bhattacharyya, S., Bi, B., Biederbeck, N., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Boisson, C., Bolmont, J., Bordas, P., Bosnjak, Z., Bottacini, E., Bradascio, F., Braiding, C., Bronzini, E., Brose, R., Brown, A. M., Brun, F., Brunetti, G., Bucciantini, N., Bulgarelli, A., Burelli, I., Burmistrov, L., Burton, M., Bylund, T., Calisse, P. G., Campoy-Ordaz, A., Cantlay, B. K., Capalbi, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, R., Carquin, E., Carrasco, M. -S., Cascone, E., Cassol, F., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cifuentes, A., Araujo, C. H. Coimbra, Conforti, V., Conte, F., Contreras, J. L., Cortina, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dalchenko, M., Dazzi, F., de Lavergne, M. de Bony, De Caprio, V., Laadim, F. De Frondat, Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., De Martino, D., de Menezes, R., de Naurois, M., De Simone, N., de Souza, V., del Valle, M. V., Delagnes, E., Giler, A. G. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Diebold, S., Djannati-Ataï, A., Djuvsland, J., Dominik, R. M., Donini, A., Dorner, D., Dörner, J., Doro, M., Anjos, R. D. C. dos, Dournaux, J. -L., Duangchan, C., Dubos, C., Dumora, D., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Evoli, C., Falceta-Goncalves, D., Ramazani, V. Fallah, Fattorini, A., Faure, A., Fedorova, E., Fegan, S., Feijen, K., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Gaggero, D., Galanti, G., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Gaug, M., Ghalumyan, A., Gianotti, F., Giarrusso, M., Giesbrecht, J., Giglietto, N., Giordano, F., Glicenstein, J. -F., Göksu, H., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Granot, J., Grau, R., Gréaux, L., Green, D., Green, J. G., Grenier, I., Grolleron, G., Grube, J., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hie, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hoang, J., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hrupec122, D., Hütten, M., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Iocco, F., Iori, M., Jamrozy, M., Janecek, P., Jankowsky, F., Jarnot, C., Jean, P., Martínez, I. Jiménez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kantzas, D., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kerszberg, D., Khélifi, B., Kissmann, R., Kleiner, T., Kluge, G., Kluźniak, W., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Leitgeb, F., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leto, G., Leuschner, F., Lindfors, E., Linhoff, M., Liodakis, I., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Luque-Escamilla, P. L., Macias, O., Mackey, J., Majumdar, P., Malyshev, D., Mandat, D., Manganaro, M., Manicò, G., Mariotti, M., Markoff, S., Márquez, I., Marquez, P., Marsella, G., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Maurin, G., Mazin, D., Melkumyan, D., Mello, A. J. T. S., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Morcuende, D., Morik, K., Morlino, G., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nagataki, S., Nakamori, T., Nemmen, R., Neyroud, N., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., O'Brien, P., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Olmi, B., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Ostrowski, M., Oya, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paoletti, R., Paredes, J. M., Parmiggiani, N., Patel, S. R., Patricelli, B., Pavlović, D., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Peron, G., Persic, M., Petrucci, P. -O., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pintore, F., Pirola, G., Pita, S., Plard, C., Podobnik, F., Pohl, M., Polo, M., Pons, E., Ponti, G., Prandini, E., Prast, J., Principe, G., Priyadarshi, C., Produit, N., Pueschel, E., Pühlhofer, G., Pumo, M. L., Punch, M., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Recchia, S., Regeard, M., Reichherzer, P., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Righi, C., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Rulten, C. B., Russo, F., Sadeh, I., Saha, L., Saito, T., Salzmann, H., Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santangelo, A., Santos-Lima, R., Sanuy, A., Šarić, T., Sarkar, A., Sarkar, S., Satalecka, K., Saturni, F. G., Savchenko, V., Scherer, A., Schipani, P., Schleicher, B., Schubert, J. L., Schussler, F., Schwanke, U., Schwefer, G., Arroyo, M. Seglar, Seiji, S., Semikoz, D., Sergijenko, O., Servillat, M., Sguera, V., Shang, R. Y., Sharma, P., Siejkowski, H., Sinha, A., Siqueira, C., Sliusar, V., Slowikowska, A., Sol, H., Specovius, A., Spencer, S. T., Spiga, D., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stawarz, Ł., Steppa, C., Stolarczyk, T., Strišković, J., Suda, Y., Suomijärvi, T., Tajima, H., Tak, D., Takahashi, M., Takeishi, R., Tanaka, S. J., Tavernier, T., Tejedor, L. A., Terauchi, K., Terrier, R., Teshima, M., Tian, W. W., Tibaldo, L., Tibolla, O., Torradeflot, F., Torres, D. F., Torresi, E., Tosti, G., Tosti, L., Tothill, N., Toussenel, F., Touzard, V., Tramacere, A., Travnicek, P., Tripodo, G., Truzzi, S., Tsiahina, A., Tutone, A., Vacula, M., Vallage, B., Vallania, P., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vigorito, C. F., Vitale, V., Vodeb, V., Voisin, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Wechakama, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yamazaki, R., Yoshida, T., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhdanov, V. I., Živec, M., Zuriaga-Puig, J., and Luque, P. De la Torre

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

Galaxy clusters are expected to be dark matter (DM) reservoirs and storage rooms for the cosmic-ray protons (CRp) that accumulate along the cluster's formation history. Accordingly, they are excellent targets to search for signals of DM annihilation and decay at gamma-ray energies and are predicted to be sources of large-scale gamma-ray emission due to hadronic interactions in the intracluster medium. We estimate the sensitivity of the Cherenkov Telescope Array (CTA) to detect diffuse gamma-ray emission from the Perseus galaxy cluster. We perform a detailed spatial and spectral modelling of the expected signal for the DM and the CRp components. For each, we compute the expected CTA sensitivity. The observing strategy of Perseus is also discussed. In the absence of a diffuse signal (non-detection), CTA should constrain the CRp to thermal energy ratio within the radius $R_{500}$ down to about $X_{500}<3\times 10^{-3}$, for a spatial CRp distribution that follows the thermal gas and a CRp spectral index $\alpha_{\rm CRp}=2.3$. Under the optimistic assumption of a pure hadronic origin of the Perseus radio mini-halo and depending on the assumed magnetic field profile, CTA should measure $\alpha_{\rm CRp}$ down to about $\Delta\alpha_{\rm CRp}\simeq 0.1$ and the CRp spatial distribution with 10% precision. Regarding DM, CTA should improve the current ground-based gamma-ray DM limits from clusters observations on the velocity-averaged annihilation cross-section by a factor of up to $\sim 5$, depending on the modelling of DM halo substructure. In the case of decay of DM particles, CTA will explore a new region of the parameter space, reaching models with $\tau_{\chi}>10^{27}$s for DM masses above 1 TeV. These constraints will provide unprecedented sensitivity to the physics of both CRp acceleration and transport at cluster scale and to TeV DM particle models, especially in the decay scenario., Comment: 93 pages (including author list, appendix and references), 143 figures. Submitted to JCAP

Published
2023
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3. Hand cooling induces changes in the kinetics of oxygen uptake

Author

Louis Finiel, Daria Neyroud, Jean-Philippe Antonietti, Anthony M. J. Sanchez, and Fabio Borrani

Subjects
Oxygen consumption, VO2 kinetic, Hand cooling, Catecholamines, Medicine, Science
Abstract

Abstract The objective of this investigation was to assess the impact of elevated catecholamine concentrations, induced through cold-water hand immersion, on the oxygen consumption (V̇O2) kinetics during intense exercise, and to contrast this effect with that of the priming effect. Ten active participants underwent three 8-minute constant work rate exercises (CWR) at ∆25%, with one CWR preceded by hand cooling (2 min at 0 °C, HC) and two consecutive CWR to induced priming effect on the second bout (SB). Pulmonary gas exchange and blood samples were analyzed to measure levels of epinephrine (E) and norepinephrine (NE). Results demonstrated a significant increase in the primary phase amplitude of V̇O2 kinetics in response to both hand HC (33.9 mL.min−1.kg−1; CI [32.2;35.7], p

Published
2024
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9. Enforcement of COVID-19 Rules

Author

Ivković, Sanja Kutnjak, primary, Maskály, Jon, additional, Donner, Christopher M., additional, Neyroud, Peter, additional, and Roch, John, additional

Published
2024
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15. A Comparative Study of Police Stress during the COVID-19 Pandemic

Author

Liu, Yang Vincent, primary, Ivković, Sanja Kutnjak, additional, Kotlaja, Marijana, additional, Neyroud, Peter, additional, Borovec, Krunoslav, additional, Wu, Yuning, additional, Mraović, Irena Cajner, additional, Sun, Ivan Y., additional, Roch, John, additional, Lobnikar, Branko, additional, Maskály, Jon, additional, França, Leandro Ayres, additional, Kobajica, Sandra, additional, Sauerman, Adri, additional, Dausan, Alrien Francisco, additional, Mihelič, Kaja Prislan, additional, and Guterres, Cristina Helena Komonski, additional

Published
2024
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17. Masking Up for the Benefit of Others

Author

Kotlaja, Marijana, primary, Vincent Liu, Yang, additional, Kutnjak Ivković, Sanja, additional, Maskály, Jon, additional, Francisco Dausan, Alrien, additional, Roch, John, additional, Sun, Ivan Y., additional, Ayres França, Leandro, additional, Cajner Mraović, Irena, additional, Lobnikar, Branko, additional, Kobajica, Sandra, additional, Komonski Guterres, Cristina Helena, additional, Wu, Yuning, additional, Prislan Mihelič, Kaja, additional, Borovec, Krunoslav, additional, Neyroud, Peter, additional, and Sauerman, Adri, additional

Published
2024
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20. Exploring Perceptions about the Changes in Reactive and Proactive Police Practices during the COVID-19 Pandemic in Bosnia and Herzegovina, Croatia, and Slovenia

Author

Kotlaja, Marijana, primary, Liu, Yang Vincent, additional, Ivković, Sanja Kutnjak, additional, Maskály, Jon, additional, Mraović, Irena Cajner, additional, Kobajica, Sandra, additional, Lobnikar, Branko, additional, Borovec, Krunoslav, additional, Mihelič, Kaja Prislan, additional, and Neyroud, Peter, additional

Published
2024
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21. Did the COVID-19 Pandemic Make the Police Work More Difficult?

Author

Ivković, Sanja Kutnjak, primary, Kotlaja, Marijana, additional, Liu, Yang Vincent, additional, Sun, Ivan Y., additional, Mraović, Irena Cajner, additional, Neyroud, Peter, additional, Wu, Yuning, additional, Borovec, Krunoslav, additional, Mihelič, Kaja Prislan, additional, Dausan, Alrien Francisco, additional, Kobajica, Sandra, additional, Maskály, Jon, additional, and Lobnikar, Branko, additional

Published
2024
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22. Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy (MecROX): An observational study protocol for mechanistic evaluation [version 2; peer review: 2 approved]

Author

Ahilanandan Dushianthan, Paul Mouncey, Daniel Martin, Lamprini Lampro, Tasnin Shahid, Victoria Goss, Amelia Francis Johnson, William Herbert, Angelica Cazley, Mark Lamond, William Jones, Karen Salmon, Florence Neyroud, Magdalena Minnion, Julian Lentaigne, Grielof Koster, Madhuri Panchal, Anthony D Postle, Helen Moyses, Michael P W Grocott, and Martin Feelisch

Subjects
Oxygen, Hyperoxia, Mechanical ventilation, Surfactant, Redox, Oxidative stress, eng, Medicine
Abstract

Background MecROX is a mechanistic sub-study of the UK-ROX trial which was designed to evaluate the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. This is based on the scientific rationale that excess oxygen is harmful. Epithelial cell damage with alveolar surfactant deficiency is characteristic of hyperoxic acute lung injury. Additionally, hyperoxaemia (excess blood oxygen levels) may exacerbate whole-body oxidative stress leading to cell death, autophagy, mitochondrial dysfunction, bioenergetic failure and multi-organ failure resulting in poor clinical outcomes. However, there is a lack of in-vivo human models evaluating the mechanisms that underpin oxygen-induced organ damage in mechanically ventilated patients. Aim The aim of the MecROX mechanistic sub-study is to assess lung surfactant composition and global systemic redox status to provide a mechanistic and complementary scientific rationale to the UK-ROX trial findings. The objectives are to quantify in-vivo surfactant composition, synthesis, and metabolism with markers of oxidative stress and systemic redox disequilibrium (as evidenced by alterations in the ‘reactive species interactome’) to differentiate between groups of conservative and usual oxygen targets. Methods and design After randomisation into the UK-ROX trial, 100 adult participants (50 in the conservative and 50 in usual care group) will be recruited at two trial sites. Blood and endotracheal samples will be taken at 0, 48 and 72 hours following an infusion of 3 mg/kg methyl-D9-choline chloride. This is a non-radioactive, stable isotope of choline (vitamin), which has been extensively used to study surfactant phospholipid kinetics in humans. This study will mechanistically evaluate the in-vivo surfactant synthesis and breakdown (by hydrolysis and oxidation), oxidative stress and redox disequilibrium from sequential plasma and bronchial samples using an array of analytical platforms. We will compare conservative and usual oxygenation groups according to the amount of oxygen administered. Trial registration: ISRCTN ISRCTN61929838, 27/03/2023 https://doi.org/10.1186/ISRCTN61929838.

Published
2024
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27. Systematic analysis of SCN5A variants associated with inherited cardiac diseases

Author

Hermida, Alexis, Jedraszak, Guillaume, Ader, Flavie, Denjoy, Isabelle, Fressart, Véronique, Maury, Phillipe, Beyls, Christophe, Bloch, Adrien, Clerici, Gaël, Daire, Elise, Defaye, Pascal, Dupin-Deguine, Delphine, Garçon, Loic, Klug, Didier, Ginglinger, Emmanuelle, Hermida, Jean-Sylvain, Jesel, Laurence, Khraiche, Diala, Kubala, Maciej, Lacotte, Jérôme, Laredo, Mikael, Leenhardt, Antoine, Le Guillou, Xavier, Lesaffre, Francois, Maltret, Alice, Magnin-Poull, Isabelle, Marijon, Eloi, Nambot, Sophie, Neyroud, Nathalie, Ninni, Sandro, Palmyre, Aurélien, Pasquie, Jean Luc, Proukhnitzky, Julie, Reant, Patricia, Richard, Pascale, Rollin, Anne, Rooryck, Caroline, Sacher, Frédéric, Schaefer, Elise, Vernier, Agathe, Winum, Pierre-François, Wahbi, Karim, Waintraub, Xavier, Waldmann, Victor, Weber, Sacha, Zouaghi, Amir, Charron, Philippe, Extramiana, Fabrice, and Gandjbakhch, Estelle

Published
2024
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30. Intracardiac electrophysiology to characterize susceptibility to ventricular arrhythmias in murine models

Author

Marine C. Ferrand, Gauthier Giordano, Nathalie Mougenot, Pierre-Léo Laporte, Nicolas Vignier, Arnaud Leclerc, Vincent Algalarrondo, Fabrice Extramiana, Flavien Charpentier, and Nathalie Neyroud

Subjects
programmed electrical stimulation, ventricular arrhythmias, electrocardiography, electrophysiology, channelopathies, cardiomyopathies, Physiology, QP1-981
Abstract

Introduction: Sudden cardiac death (SCD) and ventricular fibrillation are rare but severe complications of many cardiovascular diseases and represent a major health issue worldwide. Although the primary causes are often acute or chronic coronary diseases, genetic conditions, such as inherited channelopathies or non-ischemic cardiomyopathies are leading causes of SCD among the young. However, relevant experimental models to study the underlying mechanisms of arrhythmias and develop new therapies are still needed. The number of genetically engineered mouse models with cardiac phenotype is growing, making electrophysiological studies in mice essential tools to study arrhythmogenicity and arrhythmia mechanisms and to test novel treatments. Recently, intracardiac catheterization via the jugular vein was described to induce and record ventricular arrhythmias in living anesthetized mice. Several strategies have been reported, developed in healthy wild-type animals and based on aggressive right ventricular stimulation.Methods: Here, we report a protocol based on programmed electrical stimulation (PES) performed in clinical practice in patients with cardiac rhythm disorders, adapted to two transgenic mice models of arrhythmia - Brugada syndrome and cardiolaminopathy.Results: We show that this progressive protocol, based on a limited number of right ventricular extrastimuli, enables to reveal different rhythmic phenotypes between control and diseased mice. In this study, we provide detailed information on PES in mice, including catheter positioning, stimulation protocols, intracardiac and surface ECG interpretation and we reveal a higher susceptibility of two mouse lines to experience triggered ventricular arrhythmias, when compared to control mice.Discussion: Overall, this technique allows to characterize arrhythmias and provides results in phenotyping 2 arrhythmogenic-disease murine models.

Published
2024
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31. First time offenders as once and future victims : using police records to explore the victim-offender overlap in the Turning Point Project

Author

Neyroud, Eleanor and Treiber, Kyle

Subjects
Victim-offender overlap, Criminology
Abstract

Introduction The victim-offender overlap is an important phenomenon in criminology (Jennings et al, 2012). The research supporting the existence of the overlap is undisputable and it is arguably one of the most significant facts in criminology (Bottoms and Costello, 2010). Current research has neglected critical areas and answers are needed about how victimisation and offending co-occur and how to identify those victim-offenders who are most harmed (Bottoms and Costello, 2010). Furthermore, there is limited knowledge about what effect interventions such as out of court disposals (OOCD) have on the overlap, or if there is potential to build a triage tool or algorithm to identify the most harmed in future. Research questions These will focus on four areas victimisation - including types, frequency and harm, the victim-offender overlap, the impact on police reported victimisation by an OOCD, and finally if from criminal and victimisation history prior to the intervention date can outcomes post be predicted. 1). What does victimisation look like in low-level offenders when explored through police records in terms of prevalence, frequency, types, and harm? 2). What are the patterns and relationships between victimisation and offending in this sample? 3). What is the impact of an out of court disposal that aimed to be as effective at reducing offending as sending individuals to court on victimisation? 4). Can victimisation be predicted, and can who is most at-risk of becoming victim-offenders be predicted? Methods This PhD thesis used the police records of offending and victimisation from the sample of low-level offenders taking part in the Turning Point Project. Which was a randomised control trial (RCT) comparing sending low level offenders through court processing against an OOCD. Victimisation and offending data were collected from police data systems (CRIMES, Police National Computer, and ICIS), matched manually using name and date of birth. Before being analysed in R, basic descriptive statistics, correlations, and odds ratios were used for the first two parts of the analysis. Results from the RCT were analysed using chi square, effect sizes and survival analysis. The final section of the thesis used cox's regression and binomial logistic regression to examine the impact of pre randomisation variables. Results The victim-offender overlap was found to be extensive with 63% of the sample reporting a form of victimisation. Victimisation experiences and involvement in offending varied throughout the sample. Violence was most the most prevalent form of both victimisation and offending, caused the most victimisation harm, and had the largest overlap between victimisation and offending. The analysis of harm indicated these low-level offenders reported victimisations that equalled a total 82,180.5 harm points on the Cambridge Crime Harm Index. Using a harm score allowed five different groupings for victimisation to be created, based on the total harm and total number of victimisations suffered. Combining victimisation and offending in this sample showed some complex patterns, and while the two were clearly related this was not a simple positive correlation. The results of the RCT showed no effect of the intervention on male low-level offenders for either prevalence, frequency, survival, or harm for victimisation. However, a significant backfire effect on all measures was seen for female low-level offenders. Further research concludes this effect is most likely attributable to the significantly higher victimisation occurring prior to randomisation. Finally, the results of the regression analysis indicated key variables associated with increased risk, although the models used here produced high rates of false negatives. Victimisation is more likely to occur if the individual is still involved in offending and key predictive variables differ between victim only, offender only, non-involved and victim-offenders. With victim-offenders tending to be younger, be involved in offending or victimisation prior. Discussion Consistent with prior research low-level offenders show a substantial overlap, indicating that low-level can be experiencing problematic and concerning levels of victimisation. While the precise mechanism cannot be discerned from this study, it is proposed that understanding both the individual propensity and the environmental exposure is important. This provides some suggestions for beneficial interventions and how to target victim-offenders effectively. While the results here did not produce a clear case for the benefits of OOCD, the results indicated for male low-level offenders the OOCD was "as good as" preventing victimisation as court processing. This mirrored the findings for offending for the OOCD, suggesting that inventions that have null effects on offending are likely to have the same on victimisation. The picture for female low-level offenders is more complex, and while it is likely related to the initially higher levels further investigation would be advisable. Finally, while the models used here produced high rates of false negatives and were limited in their explanatory power, they did highlight key variables and groups to focus on. Indicating this may be an approach to explore further in future. Policy implications This research suggests six key considerations for policy: 1). Given the amount of victimisation present in low level offenders any policy aimed at low level offenders needs to be written with the explicit understanding that there will be high levels of victimisation present. 2). Prevention of violence is a key policy that should be taken from this thesis. Violence was the most prevalent form of both victimisation and offending and caused the most harm from victimisation. 3). Issues are not distributed equally throughout, and resources should be targeted to those suffering or causing the most harm. Using number alongside harm may provide a context that allows better targeting of resources. 4). Any intervention research into preventing offending needs to include a measure of victimisation alongside that of offending, and vice versa. Without these important effects may be being missed, and policy decisions are not being made based on the best evidence. 5). Due to the link between victimisation and offending in those where cooccurring issues are identified, interventions should aim to approach both simultaneously. 6). Victimisation, offending and becoming a victim-offending appear to be outcomes that could to some degree be predicted through algorithms or machine learning. Therefore, policy should consider utilising this approach to improve the accuracy of decisions. Conclusion The study reiterates the importance of the victim-offender overlap and indicates even among low-level offenders the overlap can be extensive and problematic. The results here present important findings on several aspects including the first known analysis of victimisation from a RCT aimed at prevention of offending. The potential to prevent future harm from the policy implications outlined in this study are potentially vast, and the approaching victimisation and offending simultaneously could produce wide ranging benefits. The victim-offender overlap should be the centre of future policy and research.

Published
2021
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33. Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth

Author

Daria Neyroud, Orlando Laitano, Aneesha Dasgupta, Christopher Lopez, Rebecca E. Schmitt, Jessica Z. Schneider, David W. Hammers, H. Lee Sweeney, Glenn A. Walter, Jason Doles, Sarah M. Judge, and Andrew R. Judge

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Cancer-induced muscle wasting reduces quality of life, complicates or precludes cancer treatments, and predicts early mortality. Herein, we investigate the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting induced by pancreatic cancer. Murine pancreatic cancer (KPC) cells, or saline, were injected into the pancreas of WT and MuRF1-/- mice, and tissues analyzed throughout tumor progression. KPC tumors induces progressive wasting of skeletal muscle and systemic metabolic reprogramming in WT mice, but not MuRF1-/- mice. KPC tumors from MuRF1-/- mice also grow slower, and show an accumulation of metabolites normally depleted by rapidly growing tumors. Mechanistically, MuRF1 is necessary for the KPC-induced increases in cytoskeletal and muscle contractile protein ubiquitination, and the depression of proteins that support protein synthesis. Together, these data demonstrate that MuRF1 is required for KPC-induced skeletal muscle wasting, whose deletion reprograms the systemic and tumor metabolome and delays tumor growth.

Published
2023
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37. Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study

Author

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2022
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42. Cherenkov Telescope Array Contributions to the 35th International Cosmic Ray Conference (ICRC2017)

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Acero, F., Acharya, B. S., Portella, V. Acín, Adams, C., Agudo, I., Aharonian, F., Samarai, I. Al, Alberdi, A., Alcubierre, M., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Anderson, J., Anduze, M., Angüner, E. O., Antolini, E., Antonelli, L. A., Antonuccio, V., Antoranz, P., Aramo, C., Araya, M., Arcaro, C., Armstrong, T., Arqueros, F., Arrabito, L., Arrieta, M., Asano, K., Asano, A., Ashley, M., Aubert, P., Singh, C. B., Babic, A., Backes, M., Bajtlik, S., Balazs, C., Balbo, M., Ballester, O., Ballet, J., Ballo, L., Balzer, A., Bamba, A., Bandiera, R., Barai, P., Barbier, C., Barcelo, M., Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Bauer, C., Becciani, U., Becherini, Y., Tjus, J. Becker, Bednarek, W., Belfiore, A., Benbow, W., Benito, M., Berge, D., Bernardini, E., Bernardini, M. G., Bernardos, M., Bernhard, S., Bernlöhr, K., Salucci, C. Bertinelli, Bertucci, B., Besel, M. -A., Beshley, V., Bettane, J., Bhatt, N., Bhattacharyya, W., Bhattachryya, S., Biasuzzi, B., Bicknell, G., Bigongiari, C., Biland, A., Bilinsky, A., Bird, R., Bissaldi, E., Biteau, J., Bitossi, M., Blanch, O., Blasi, P., Blazek, J., Boccato, C., Bockermann, C., Boehm, C., Bohacova, M., Boisson, C., Bolmont, J., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Borkowski, J., Bose, R., Bosnjak, Z., Böttcher, M., Boutonnet, C., Bouyjou, F., Bowman, L., Bozhilov, V., Braiding, C., Brau-Nogué, S., Bregeon, J., Briggs, M., Brill, A., Brisken, W., Bristow, D., Britto, R., Brocato, E., Brown, A. M., Brown, S., Brügge, K., Brun, P., Brun, F., Brunetti, L., Brunetti, G., Bruno, P., Bryan, M., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Buson, S., Buss, J., Byrum, K., Caccianiga, A., Cameron, R., Canelli, F., Canestrari, R., Capalbi, M., Capasso, M., Capitanio, F., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Cárdenas, V., Cardenzana, J., Cardillo, M., Carlile, C., Caroff, S., Carosi, R., Carosi, A., Carquín, E., Carr, J., Casandjian, J. -M., Casanova, S., Cascone, E., Castro-Tirado, A. J., Mora, J. Castroviejo, Catalani, F., Catalano, O., Cauz, D., Silva, C. Celestino, Celli, S., Cerruti, M., Chabanne, E., Chadwick, P., Chakraborty, N., Champion, C., Chatterjee, A., Chaty, S., Chaves, R., Chen, A., Chen, X., Cheng, K., Chernyakova, M., Chikawa, M., Chitnis, V. R., Christov, A., Chudoba, J., Cieślar, M., Clark, P., Coco, V., Colafrancesco, S., Colin, P., Colombo, E., Colome, J., Colonges, S., Conforti, V., Connaughton, V., Conrad, J., Contreras, J. L., Cornat, R., Cortina, J., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Covone, G., Cristofari, P., Criswell, S. J., Crocker, R., Croston, J., Crovari, C., Cuadra, J., Cuevas, O., Cui, X., Cumani, P., Cusumano, G., D'Aì, A., D'Ammando, F., D'Avanzo, P., D'Urso, D., Da Vela, P., Dale, Ø., Dang, V. T., Dangeon, L., Daniel, M., Davids, I., Dawson, B., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De Lisio, C., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., De Lucia, M., Neto, J. R. T. de Mello, de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., De Persio, F., de Souza, V., Decock, J., Deil, C., Deiml, P., Del Santo, M., Delagnes, E., Deleglise, G., Reznicek, M. Delfino, Delgado, C., Mengual, J. Delgado, Della Ceca, R., della Volpe, D., Detournay, M., Devin, J., Di Girolamo, T., Di Giulio, C., Di Pierro, F., Di Venere, L., Diaz, L., Díaz, C., Dib, C., Dickinson, H., Diebold, S., Digel, S., Djannati-Ataï, A., Doert, M., Domínguez, A., Prester, D. Dominis, Donnarumma, I., Dorner, D., Doro, M., Dournaux, J. -L., Downes, T., Drake, G., Drappeau, S., Drass, H., Dravins, D., Drury, L., Dubus, G., Morå, K. Dundas, Durkalec, A., Dwarkadas, V., Ebr, J., Eckner, C., Edy, E., Egberts, K., Einecke, S., Eisch, J., Eisenkolb, F., Ekoume, T. R. N., Eleftheriadis, C., Elsässer, D., Emmanoulopoulos, D., Ernenwein, J. -P., Escarate, P., Eschbach, S., Espinoza, C., Evans, P., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Falcone, A., Ramazani, V. Fallah, Farakos, K., Farrell, E., Fasola, G., Favre, Y., Fede, E., Fedora, R., Fedorova, E., Fegan, S., Fernandez-Alonso, M., Fernández-Barral, A., Ferrand, G., Ferreira, O., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovic, M., Fink, D., Finley, J. P., Finley, C., Finoguenov, A., Fioretti, V., Fiorini, M., Flores, H., Foffano, L., Föhr, C., Fonseca, M. V., Font, L., Fontaine, G., Fornasa, M., Fortin, P., Fortson, L., Fouque, N., Fraga, B., Franco, F. J., Coromina, L. Freixas, Fruck, C., Fugazza, D., Fujita, Y., Fukami, S., Fukazawa, Y., Fukui, Y., Funk, S., Furniss, A., Füßling, M., Gabici, S., Gadola, A., Gallant, Y., Galloway, D., Gallozzi, S., Garcia, B., Garcia, A., Gil, R. García, López, R. Garcia, Garczarczyk, M., Gardiol, D., Gargano, F., Gargano, C., Garozzo, S., Garrido-Ruiz, M., Gascon, D., Gasparetto, T., Gaté, F., Gaug, M., Gebhardt, B., Gebyehu, M., Geffroy, N., Genolini, B., Ghalumyan, A., Ghedina, A., Ghirlanda, G., Giammaria, P., Gianotti, F., Giebels, B., Giglietto, N., Gika, V., Gimenes, R., Giommi, P., Giordano, F., Giovannini, G., Giro, E., Giroletti, M., Gironnet, J., Giuliani, A., Glicenstein, J. -F., Gnatyk, R., Godinovic, N., Goldoni, P., Gómez, J. L., Gómez-Vargas, G., González, M. M., González, J. M., Gothe, K. S., Gotz, D., Goullon, J., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Grasseau, G., Gredig, R., Green, A. J., Greenshaw, T., Grenier, I., Griffiths, S., Grillo, A., Grondin, M. -H., Grube, J., Guarino, V., Guest, B., Gueta, O., Gunji, S., Gyuk, G., Hadasch, D., Hagge, L., Hahn, J., Hahn, A., Hakobyan, H., Hara, S., Hardcastle, M. J., Hassan, T., Haubold, T., Haupt, A., Hayashi, K., Hayashida, M., He, H., Heller, M., Helo, J. C., Henault, F., Henri, G., Hermann, G., Hermel, R., Llorente, J. Herrera, Herrero, A., Hervet, O., Hidaka, N., Hinton, J., Hiroshima, N., Hirotani, K., Hnatyk, B., Hoang, J. K., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Hörbe, M., Horns, D., Horvath, P., Houles, J., Hovatta, T., Hrabovsky, M., Hrupec, D., Huet, J. -M., Hughes, G., Hui, D., Hull, G., Humensky, T. B., Hussein, M., Hütten, M., Iarlori, M., Ikeno, Y., Illa, J. M., Impiombato, D., Inada, T., Ingallinera, A., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Ionica, M., Iori, M., Iriarte, A., Ishio, K., Israel, G. L., Iwamura, Y., Jablonski, C., Jacholkowska, A., Jacquemier, J., Jamrozy, M., Janecek, P., Jankowsky, F., Jankowsky, D., Jansweijer, P., Jarnot, C., Jean, P., Johnson, C. A., Josselin, M., Jung-Richardt, I., Jurysek, J., Kaaret, P., Kachru, P., Kagaya, M., Kakuwa, J., Kalekin, O., Kankanyan, R., Karastergiou, A., Karczewski, M., Karkar, S., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kawanaka, N., Kaye, L., Kazanas, D., Kelley-Hoskins, N., Khélifi, B., Kieda, D. B., Kihm, T., Kimeswenger, S., Kimura, S., Kisaka, S., Kishida, S., Kissmann, R., Kluźniak, W., Knapen, J., Knapp, J., Knödlseder, J., Koch, B., Kocot, J., Kohri, K., Komin, N., Kong, A., Konno, Y., Kosack, K., Kowal, G., Koyama, S., Kraus, M., Krause, M., Krauß, F., Krennrich, F., Kruger, P., Kubo, H., Kudryavtsev, V., Mezek, G. Kukec, Kumar, S., Kuroda, H., Kushida, J., Kushwaha, P., La Palombara, N., La Parola, V., La Rosa, G., Lahmann, R., Lalik, K., Lamanna, G., Landoni, M., Landriu, D., Landt, H., Lang, R. G., Lapington, J., Laporte, P., Blanc, O. Le, Flour, T. Le, Sidaner, P. Le, Leach, S., Leckngam, A., Lee, S. -H., Lee, W. H., Lees, J. -P., Lefaucheur, J., de Oliveira, M. A. 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Mc, McHardy, I., Medina, C., Melandri, A., Melioli, C., Melkumyan, D., Mereghetti, S., Meunier, J. -L., Meures, T., Meyer, M., Micanovic, S., Michael, T., Michałowski, J., Mievre, I., Miller, J., Minaya, I. A., Mineo, T., Mirabel, F., Miranda, J. M., Mirzoyan, R., Mitchell, A., Mizuno, T., Moderski, R., Mohammed, M., Mohrmann, L., Molijn, C., Molinari, E., Moncada, R., Montaruli, T., Monteiro, I., Mooney, D., Moore, P., Moralejo, A., Morcuende-Parrilla, D., Moretti, E., Mori, K., Morlino, G., Morris, P., Morselli, A., Moscato, F., Motohashi, D., Moulin, E., Mueller, S., Mukherjee, R., Munar, P., Mundell, C., Mundet, J., Murach, T., Muraishi, H., Murase, K., Murphy, A., Nagai, A., Nagar, N., Nagataki, S., Nagayoshi, T., Nagesh, B. K., Naito, T., Nakajima, D., Nakamori, T., Nakamura, Y., Nakayama, K., Naumann, D., Nayman, P., Neise, D., Nellen, L., Nemmen, R., Neronov, A., Neyroud, N., Nguyen, T., Nguyen, T. T., Trung, T. Nguyen, Nicastro, L., Nicolau-Kukliński, J., Niemiec, J., Nieto, D., Nievas-Rosillo, M., Nikołajuk, M., Nishijima, K., Nishikawa, K. -I., Nishiyama, G., Noda, K., Nogues, L., Nolan, S., Nosek, D., Nöthe, M., Novosyadlyj, B., Nozaki, S., Nunio, F., O'Brien, P., Oakes, L., Ocampo, C., Ochoa, J. P., Oger, R., Ohira, Y., Ohishi, M., Ohm, S., Okazaki, N., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlati, A., Osborne, J. P., Ostrowski, M., Otte, N., Ou, Z., Ovcharov, E., Oya, I., Ozieblo, A., Padovani, M., Paiano, S., Paizis, A., Palacio, J., Palatiello, M., Palatka, M., Pallotta, J., Panazol, J. -L., Paneque, D., Panter, M., Paoletti, R., Paolillo, M., Papitto, A., Paravac, A., Paredes, J. M., Pareschi, G., Parsons, R. D., Paśko, P., Pavy, S., Pe'er, A., Pech, M., Pedaletti, G., Del Campo, P. Peñil, Perez, A., Pérez-Torres, M. A., Perri, L., Perri, M., Persic, M., Petrashyk, A., Petrera, S., Petrucci, P. -O., Petruk, O., Peyaud, B., Pfeifer, M., Piano, G., Piel, Q., Pieloth, D., Pintore, F., García, C. Pio, Pisarski, A., Pita, S., Pizarro, L., Platos, Ł., Pohl, M., Poireau, V., Pollo, A., Porthault, J., Poutanen, J., Pozo, D., Prandini, E., Prasit, P., Prast, J., Pressard, K., Principe, G., Prokhorov, D., Prokoph, H., Prouza, M., Pruteanu, G., Pueschel, E., Pühlhofer, G., Puljak, I., Punch, M., Pürckhauer, S., Queiroz, F., Quinn, J., Quirrenbach, A., Rafighi, I., Rainò, S., Rajda, P. J., Rando, R., Rannot, R. C., Razzaque, S., Reichardt, I., Reimer, O., Reimer, A., Reisenegger, A., Renaud, M., Reposeur, T., Reville, B., Rezaeian, A. H., Rhode, W., Ribeiro, D., Ribó, M., Richer, M. G., Richtler, T., Rico, J., Rieger, F., Riquelme, M., Ristori, P. R., Rivoire, S., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rojas, G., Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rosen, S., Lees, S. Rosier, Rousselle, J., Rovero, A. C., Rowell, G., Rudak, B., Rugliancich, A., del Mazo, J. E. Ruíz, Rujopakarn, W., Rulten, C., Russo, F., Saavedra, O., Sabatini, S., Sacco, B., Sadeh, I., Hatlen, E. Sæther, Safi-Harb, S., Sahakian, V., Sailer, S., Saito, T., Sakaki, N., Sakurai, S., Salek, D., Greus, F. Salesa, Salina, G., Sanchez, D., Sánchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Santangelo, A., Santos, E. M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Satalecka, K., Sato, Y., Saturni, F. G., Savalle, R., Sawada, M., Schanne, S., Schioppa, E. J., Schlenstedt, S., Schmidt, T., Schmoll, J., Schneider, M., Schoorlemmer, H., Schovanek, P., Schulz, A., Schussler, F., Schwanke, U., Schwarz, J., Schweizer, T., Schwemmer, S., Sciacca, E., Scuderi, S., Seglar-Arroyo, M., Segreto, A., Seitenzahl, I., Semikoz, D., Sergijenko, O., Serre, N., Servillat, M., Seweryn, K., Shah, K., Shalchi, A., Sharma, M., Shellard, R. C., Shilon, I., Sidoli, L., Sidz, M., Siejkowski, H., Silk, J., Sillanpää, A., Simone, D., Singh, B. B., Sironi, G., Sitarek, J., Sizun, P., Sliusar, V., Slowikowska, A., Smith, A., Sobczyńska, D., Sokolenko, A., Sol, H., Sottile, G., Springer, W., Stahl, O., Stamerra, A., Stanič, S., Starling, R., Staszak, D., Stawarz, Ł., Steenkamp, R., Stefanik, S., Stegmann, C., Steiner, S., Stella, C., Stephan, M., Sternberger, R., Sterzel, M., Stevenson, B., Stodulska, M., Stodulski, M., Stolarczyk, T., Stratta, G., Straumann, U., Stuik, R., Suchenek, M., Suomijarvi, T., Supanitsky, A. 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Troyano, Tsirou, M., Tsujimoto, S., Tsuru, T., Uchiyama, Y., Umana, G., Uslenghi, M., Vagelli, V., Vagnetti, F., Valentino, M., Vallania, P., Valore, L., Berg, A. M. Van den, van Driel, W., van Eldik, C., van Soelen, B., Vandenbroucke, J., Vanderwalt, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Vázquez, J. R., Acosta, M. Vázquez, Vecchi, M., Vega, A., Veitch, P., Venault, P., Venter, C., Vercellone, S., Veres, P., Vergani, S., Verzi, V., Vettolani, G. P., Veyssiere, C., Viana, A., Vicha, J., Vigorito, C., Villanueva, J., Vincent, P., Vink, J., Visconti, F., Vittorini, V., Voelk, H., Voisin, V., Vollhardt, A., Vorobiov, S., Vovk, I., Vrastil, M., Vuillaume, T., Wagner, S. J., Wagner, R., Wagner, P., Wakely, S. P., Walstra, T., Walter, R., Ward, M., Ward, J. E., Warren, D., Watson, J. J., Webb, N., Wegner, P., Weiner, O., Weinstein, A., Weniger, C., Werner, F., Wetteskind, H., White, M., White, R., Wierzcholska, A., Wiesand, S., Wijers, R., Wilcox, P., Wilhelm, A., Wilkinson, M., Will, M., Williams, D. A., Winter, M., Wojcik, P., Wolf, D., Wood, M., Wörnlein, A., Wu, T., Yadav, K. K., Yaguna, C., Yamamoto, T., Yamamoto, H., Yamane, N., Yamazaki, R., Yanagita, S., Yang, L., Yelos, D., Yoshida, T., Yoshida, M., Yoshiike, S., Yoshikoshi, T., Yu, P., Zaborov, D., Zacharias, M., Zaharijas, G., Zajczyk, A., Zampieri, L., Zandanel, F., Zanin, R., Sanchez, R. Zanmar, Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., Ziegler, A., Ziemann, J., Ziętara, K., Zink, A., Ziółkowski, J., Zitelli, V., Zoli, A., and Zorn, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

List of contributions from the Cherenkov Telescope Array Consortium presented at the 35th International Cosmic Ray Conference, July 12-20 2017, Busan, Korea., Comment: Index of Cherenkov Telescope Array conference proceedings at the ICRC2017, Busan, Korea

Published
2017

43. Brain Metastases from Genito-Urinary Cancers in the Canton of Geneva (Switzerland): Study of Incidence, Management and Outcomes.

Author

Gonnet, Philippe, Marinari, Eliana, Achard, Vérane, Schaffar, Robin, Neyroud-Caspar, Isabelle, May, Adrien, Goga, Cristina, Dietrich, Pierre-Yves, Schaller, Karl, and Patrikidou, Anna

Subjects
BLADDER tumors, ACADEMIC medical centers, PENILE tumors, TREATMENT effectiveness, CANCER patients, RETROSPECTIVE studies, PROSTATE tumors, RADIOSURGERY, DESCRIPTIVE statistics, GENITOURINARY organ tumors, METASTASIS, KAPLAN-Meier estimator, LOG-rank test, MEDICAL records, ACQUISITION of data, RENAL cell carcinoma, GERMINOMA, TUMOR classification, PROGRESSION-free survival, COMPARATIVE studies, DATA analysis software, SOCIODEMOGRAPHIC factors, BRAIN tumors, OVERALL survival, DISEASE incidence, PROPORTIONAL hazards models
Abstract

Simple Summary: Incidence of brain metastases from genito-urinary cancers has increased over the last years due to improved imaging techniques and better survival outcomes for patients even at an advanced metastatic stage thanks to therapeutic advances. However, no clear consensus exists on their management, and every case ought to be discussed in a multidisciplinary panel. We perform a single-centre retrospective study to report on incidence, patient demographics, clinicopathological characteristics, and treatment modalities. We also manage to identify predictive factors of outcome. Background: Incidence of brain metastases is precisely unknown and there is no clear consensus on their management. We aimed to determine the incidence of brain metastases among patients with genito-urinary primaries, present patients' characteristics and identify prognostic factors. Method: We identified 51 patients treated in Geneva University Hospitals between January 1992 and December 2019. We retrospectively correlated their overall survival with 23 variables. We repeated a multivariate analysis with significant variables. Results: Overall incidence of Brain Metastases (BMs) among Genito-Urinary (GU) patients is estimated to be 1.76% (range per primary GU tumour type: 0.00–6.65%). BMs originate from germ cell tumours in two cases (3.92%), from urothelial cell carcinoma in 15 cases (29.41%), from prostate cancer in 13 cases (25.49%), and from renal cell carcinoma in 21 cases (41.18%); there are no BMs from penile cancer in our cohort. The median age at BM diagnosis is 67 years old (range: 25–92). Most patients (54%) have a stage IV disease at initial diagnosis and 11 patients (22%) have BM at initial diagnosis. Only six patients (12%) are asymptomatic at BM diagnosis. The median Overall Survival (OS) from BM diagnosis is 3 months (range: 0–127). Five patients (10%) are long survivors (OS > 24 months). OS is significantly influenced by patient performance status and administration of systemic treatment. In the absence of meningeal carcinomatosis, OS is influenced by systemic treatment and stereotactic radiosurgery. We also apply the Graded Prognostic Assessment (GPA) score to our cohort and note significant differences between groups. Conclusion: Brain metastases from solid tumours is not a uniform disease, with a prognosis varying a lot among patients. The optimal management for patients with genito-urinary malignancies with brain metastases remain unclear and further research is needed. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy (MecROX): An observational study protocol for mechanistic evaluation

Author

Dushianthan, Ahilanandan, primary, Martin, Daniel, additional, Mouncey, Paul, additional, Shahid, Tasnin, additional, Lampro, Lamprini, additional, Johnson, Amelia Francis, additional, Goss, Victoria, additional, Cazley, Angelica, additional, Herbert, William, additional, Jones, William, additional, Lamond, Mark, additional, Neyroud, Florence, additional, Salmon, Karen, additional, Lentaigne, Julian, additional, Minnion, Magdalena, additional, Panchal, Madhuri, additional, Koster, Grielof, additional, Moyses, Helen, additional, Postle, Anthony D, additional, Feelisch, Martin, additional, and Grocott, Michael P W, additional

Published
2024
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47. Policing the Pandemic

Author

Ivković, Sanja Kutnjak, primary, Maskály, Jon, additional, Donner, Christopher M., additional, Neyroud, Peter, additional, and Roch, John, additional

Published
2024
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49. Extra-cellular vesicles of the male genital tract: new actors in male fertility?

Author

Anne-Sophie Neyroud, Régina Chiechio, Marina Yefimova, Maria Josè Lo Faro, Nathalie Dejucq-Rainsford, Sylvie Jaillard, Pascale Even-Hernandez, Valérie Marchi, and Célia Ravel

Subjects
Extra-cellular vesicles, Male genital tract, Prostasomes, Epididymosomes, Myelinosomes, Medicine (General), R5-920
Abstract

Résumé Les Vésicules Extracellulaires (VE) sont des constituants d’origine membranaire contenant des protéines solubles ou membranaires, des lipides, des métabolites ou des acides nucléiques. Ces vésicules sont très hétérogènes en taille et en contenu. Trois catégories de VE ont été décrites dans le tractus génital mâle: les microvésicules, les myélinosomes et les exosomes. Les types de VE sont différents selon le lieu de production testiculaire, prostatique ou encore épididymaire. Il a été montré que les VE peuvent fusionner et délivrer une information à la cellule réceptrice, en l’occurrence le spermatozoïde dans le tractus génital mâle. La cryo-microscopie électronique reste la technique de référence pour déterminer la morphologie des VE mais la quantification de la concentration absolue de ces VE dans les liquides biologiques reste un challenge dans le cadre d’une approche clinique. Le domaine de la biodétection s’est. considérablement développé avec l’introduction des nanomatériaux dans les biocapteurs et va permettre de mieux comprendre l’impact de ces VE. Or les modifications fonctionnelles des gamètes mâles résultent d’interactions avec les composants du liquide intraluminal tout le long du tractus génital et dépendent de la sécrétion et de l’absorption de protéines et de lipides du microenvironnement local. On ne peut donc pas exclure la possibilité d’une modulation épigénétique des informations qui seront transmises à l’embryon donc à la génération suivante via les VE.

Published
2021
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50. Learning to field test in policing : using an analysis of completed randomised controlled trials involving the police to develop a grounded theory on the factors contributing to high levels of treatment integrity in Police Field Experiments

Author

Neyroud, Peter William and Sherman, Lawrence

Subjects
363.2, Policing, randomised controlled trials, treatment integrity
Abstract

Evidence-based policing (EBP) has emerged as a key strand of police innovation since Sherman’s (1998) Police Foundation lecture. However, for others EBP raises as many questions as answers. One of the most contentious areas is the role advocated for randomised controlled trials in testing practice and developing knowledge to support EBP. RCTs are controversial with some scholars who argue that policing is not comparable to medicine and that RCTs are unable to reflect the complexity of the police role and context. Even those who advocate the use of RCTs recognise that there are significant challenges in achieving the high dosage and high fidelity that a successful experiment requires. This dissertation responds to these challenges by analysing the completed randomised controlled trials in policing and using a case study, Operation Turning Point, to identify the factors that may contribute to the conduct and management of police field trials with high levels of treatment integrity. In the introduction, Chapter 1, the approach is set out, framed around grounded theory, to be developed in four, linked, chapters. Chapter 2 is focused on understanding treatment integrity in RCTs involving the police: A search for police RCTs is produced 122 Police RCTs completed and reported by 2016. The levels of treatment integrity are analysed. 78 of the 122 RCTs exceeded a 60% threshold, with 49 being above 90%. In Chapter 3, a “novice theory” is developed and tested as an explanation for levels of treatment integrity in police randomised controlled trials: Analysis of the 122 RCTs suggests that “novice theory” can provide an explanation for the general patterns of treatment integrity. Further detailed analysis suggested that there are, however, other factors which may be important in determining the treatment integrity. These are developed in Chapter 4, which centres on a case study of Operation Turning Point. Using published case studies and an analysis of juvenile justice RCTs, a potential framework of operational factors is developed that appear to be important in effective conduct and management. The Turning Point case study is used to develop and expand on those operational factors. Finally, taking the two together, the analysis concluded that, beyond the operational factors, there were some more strategic, “protective factors” that were also critical. These are developed in Chapter 5, by using the coding and analysis of interviews with a sample of key staff involved in Turning Point Our analysis suggests that novice theory needs to be understood in the context of both the operational and protective factors that we have identified. Taken together these findings indicate the potential advantages of building institutional frameworks in which the development of practitioners and researchers and the conduct and management of experimental research could be brought closer together. We conclude with ten recommendations designed to improve the treatment integrity of police RCTs.

Published
2017
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