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5. Safety and feasibility of transbronchial microwave ablation for subpleural lung nodules.

Author

Chang, Aliss Tsz Ching, Chan, Joyce Wing Yan, Siu, Ivan Chi Hin, Lau, Rainbow Wing Hung, and Ng, Calvin Sze Hang

Abstract

Background: Transbronchial microwave ablation in treating lung nodules is gaining popularity. However, microwave ablation in subpleural lung nodules raised concerns about pleural-based complications due to the proximity between the pleura and the ablation zone. Methods: Patients who underwent transbronchial microwave ablation between March 2019 and November 2022 were included in this analysis. The lung nodules were categorized into the subpleural group—less than 5 mm distance to the nearest pleural surface; the deep nodule group—larger or equal to 5 mm distance to the nearest pleural surface. A review of the safety profile of subpleural lung nodule ablation was conducted. Results: Eighty-two lung nodules (n = 82) from 77 patients were treated. The mean nodule size was 14.2 ± 5.50 mm. The technical success rate was 100%. The mean procedural time was 133 min. No statistically significant differences were detected in the complication rate and the length of stay between the subpleural and deep nodule groups. Complications occured in 21 nodules (25.6%). No minor pneumothorax was reported. Total five cases of pneumothorax required drainage were observed (6.06% in subpleural nodules [ n = 2] vs. 6.12% in deep nodules [ n = 3], p = 0.991). Total seven cases of pleuritic chest pain were observed (12.1% in subpleural nodules [ n = 4] vs. 6.12% in deep nodules [ n = 3], p = 0.340). Conclusions: This single-center retrospective analysis found no significant difference in the safety outcomes between subpleural and nonsubpleural lung nodule ablation. The overall rate of complications was low in the cohort. This demonstrated that transbronchial microwave was feasible and safe for most lung nodules. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung Carcinoma (Adv. Sci. 1/2024)

Author

Tang, Philip Chiu‐Tsun, primary, Chan, Max Kam‐Kwan, additional, Chung, Jeff Yat‐Fai, additional, Chan, Alex Siu‐Wing, additional, Zhang, Dongmei, additional, Li, Chunjie, additional, Leung, Kam‐Tong, additional, Ng, Calvin Sze‐Hang, additional, Wu, Yi, additional, To, Ka‐Fai, additional, Lan, Hui‐Yao, additional, and Tang, Patrick Ming‐Kuen, additional

Published
2024
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9. Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung Carcinoma

Author

Tang, Philip Chiu‐Tsun, primary, Chan, Max Kam‐Kwan, additional, Chung, Jeff Yat‐Fai, additional, Chan, Alex Siu‐Wing, additional, Zhang, Dongmei, additional, Li, Chunjie, additional, Leung, Kam‐Tong, additional, Ng, Calvin Sze‐Hang, additional, Wu, Yi, additional, To, Ka‐Fai, additional, Lan, Hui‐Yao, additional, and Tang, Patrick Ming‐Kuen, additional

Published
2023
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11. Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain

Author

Tang, Philip Chiu-Tsun, primary, Chung, Jeff Yat-Fai, additional, Liao, Jinyue, additional, Chan, Max Kam-Kwan, additional, Chan, Alex Siu-Wing, additional, Cheng, Guangyao, additional, Li, Chunjie, additional, Huang, Xiao-Ru, additional, Ng, Calvin Sze-Hang, additional, Lam, Eric W-F, additional, Zhang, Dongmei, additional, Ho, Yi-Ping, additional, To, Ka-Fai, additional, Leung, Kam-Tong, additional, Jiang, Xiaohua, additional, Ko, Ho, additional, Lee, Tin-Lap, additional, Lan, Hui-Yao, additional, and Tang, Patrick Ming-Kuen, additional

Published
2022
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12. Use of Indocyanine Green Fluorescence Imaging in Thoracic and Esophageal Surgery

Author

Ng, Calvin Sze-Hang, primary, Ong, Boon-Hean, additional, Chao, Yin Kai, additional, Wright, Gavin M., additional, Sekine, Yasuo, additional, Wong, Ian, additional, Hao, Zhexue, additional, Zhang, Guangjian, additional, Chaturvedi, Harit, additional, Thammineedi, Subramanyeshwar Rao, additional, Law, Simon, additional, and Kim, Hyun Koo, additional

Published
2022
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14. Organoids in Lung Cancer Management

Author

Li, Yushi, Chan, Joyce W. Y., Lau, Rainbow W. H., Cheung, Winnie W. Y., Wong, Alissa Michelle, Wong, Aikha M., Wong, Nathalie, and Ng, Calvin Sze Hang

Subjects
lung cancer, RD1-811, disease model, Surgery, Review, drug screening, respiratory system, preclinical model, organoids, respiratory tract diseases
Abstract

Lung cancer is a complex milieu of genomically altered cancer cells, a diverse collection of differentiated cells and nonneoplastic stroma. Lung cancer organoids is a three-dimensional structure grown from patient cancer tissue that could mimic in vivo complex behavior and cellular architecture of the cancer. Furthermore, the genomic alterations of the primary lung tumor is captured ex vivo. Lung cancer organoids have become an important preclinical model for oncology studies in recent years. It could be used to model the development of lung cancer, investigate the process of tumorigenesis, and also study the signaling pathways. The organoids could also be a platform to perform drug screening and biomarker validation of lung cancer, providing a promising prediction of patient-specific drug response. In this review, we described how lung cancer organoids have opened new avenues for translating basic cancer research into clinical therapy and discussed the latest and future developments in organoid technology, which could be further applied in lung cancer organoids research.

Published
2021

15. Segmental resection is associated with decreased survival in patients with stage IA non-small cell lung cancer with a tumor size of 21–30 mm.

Author

Xiangyang , Yu, Rusi, Zhang, Mengqi, Zhang, Yongbin, Lin, Xuewen, Zhang, Yingsheng, Wen, Longjun, Yang, Zirui, Huang, Wang, Gongming, Dechang, Zhao, Gonzalez, Michel, Baste, Jean-Marc, Petersen, René Horsleben, Ng, Calvin Sze Hang, Brunelli, Alessandro, Lie , Zheng, Zhang, Lanjun, Xiangyang , Yu, Rusi, Zhang, Mengqi, Zhang, Yongbin, Lin, Xuewen, Zhang, Yingsheng, Wen, Longjun, Yang, Zirui, Huang, Wang, Gongming, Dechang, Zhao, Gonzalez, Michel, Baste, Jean-Marc, Petersen, René Horsleben, Ng, Calvin Sze Hang, Brunelli, Alessandro, Lie , Zheng, and Zhang, Lanjun

Abstract

Background: The feasibility of segmental resection for early-stage non-small cell lung cancer (NSCLC) is still controversial. This study aimed to compare survival outcomes following lobectomy and segmental resection in patients with pathological T1cN0M0 (tumor size 21–30 mm) NSCLC. Methods: Patients diagnosed between 1998 and 2016 with pathological stage IA NSCLC and with tumors measuring 21–30 mm were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The observational outcomes were cancer-specific survival (CSS) and overall survival (OS) at 5 years. Univariate survival analysis was carried out to identify potential prognostic factors of prolonged survival. Cox proportional hazards model was used to adjust for confounding factors. Additionally, pairwise comparisons were conducted between lobectomy and segmental resection for CSS and OS, and forest plots were drawn. Results: Of the 9,580 patients analyzed, 400 patients (4.2%) underwent segmental resections. Patients with older age (P<0.001), smaller tumors (P<0.001), and left-sided tumors (P=0.002) were more likely to receive segmental resection. No difference was found in the operative mortality rates between the segmental resection group and the lobectomy group (1.0% vs. 1.2%, P=0.707). The CSS (HR, 1.429; 95% CI, 1.166–1.752; P=0.001) and OS (HR, 1.348; 95% CI, 1.176–1.544; P<0.001) in the segmental resection group were significantly worse than those in the lobectomy group. Subgroup analyses by age, year of diagnosis, sex, tumor size, histology, grade, and the number of dissected lymph nodes also confirmed that lobectomy was associated with improved CSS and OS. Conclusions: Lobectomy and thorough removal of lymph nodes should continue to be the recommended standard of care for patients with surgically resectable stage IA NSCLC with tumor size of 21–30 mm.

Published
2021

16. Ten-Year Trends of Clinicopathologic Features and Surgical Treatment of Lung Cancer in China

Author

Zang, Ruochuan, Shi, Ju-Fang, Lerut, Toni E, Wang, Le, Liu, Chia-Chuan, Brunelli, Alessandro, Petersen, René Horsleben, Ng, Calvin Sze Hang, Lim, Eric, Gao, Shugeng, Zang, Ruochuan, Shi, Ju-Fang, Lerut, Toni E, Wang, Le, Liu, Chia-Chuan, Brunelli, Alessandro, Petersen, René Horsleben, Ng, Calvin Sze Hang, Lim, Eric, and Gao, Shugeng

Abstract

BACKGROUND: Lung cancer has changed significantly during the past 2 decades in its epidemiology and treatment. This retrospective analysis used data from 7 major areas of China over 10 years to evaluate clinicopathologic and surgical treatment trends of lung cancer in China during the past decade.METHODS: Data from 7184 patients with primary lung cancer who were treated between 2005 and 2014 in 8 provinces of China were retrospectively collected. Their clinicopathologic features and surgical treatment information were recorded. Simple linear regression models and the Cochrane-Armitage trend test were used to assess temporal trends.RESULTS: The proportion of female patients (from 57.4% to 59.6%; P < .001) and nonsmoking patients (from 37.1% to 48.9%; P < .001) and of patients with a family history of malignant tumors (from 7.0% to 11.5%; P < .001) increased significantly. The percentage of adenocarcinomas increased significantly (from 36.4% to 53.5%; P < .001), with a decrease in squamous cell carcinomas (from 45.4% to 34.4%; P < .001). After 2008, the application of minimally invasive surgery significantly increased in China (from 2.4% in 2008 to 34.4% in 2014; P < .001), with a decline in the rate of conversion to open operation (from 14.3% in 2008 to 4.8% in 2014; P = .146) and an increase in the proportion of systematic mediastinal lymph node dissection (from 50.0% in 2008 to 84.1% in 2014; P = .001).CONCLUSIONS: This study investigated recent 10-year trends in the clinicopathologic features and surgical treatment of lung cancer in China and found significant important changes. These findings provide valuable information and evidence for the future control of the disease in China.

Published
2020

17. Distinct Molecular Landscape of Epstein–Barr Virus Associated Pulmonary Lymphoepithelioma-Like Carcinoma Revealed by Genomic Sequencing

Author

Chau, Shuk-Ling, primary, Tong, Joanna Hung-Man, additional, Chow, Chit, additional, Kwan, Johnny Sheung-Him, additional, Lung, Raymond Wai-Ming, additional, Chung, Lau-Ying, additional, Tin, Edith Ka-Yee, additional, Wong, Shela Shu-Yan, additional, Cheung, Alvin Ho-Kwan, additional, Lau, Rainbow Wing-Hung, additional, Ng, Calvin Sze-Hang, additional, Mok, Tony Shu-Kam, additional, Lo, Kwok-Wai, additional, and To, Ka-Fai, additional

Published
2020
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21. Atlas of uniportal video assisted thoracic surgery

Author

Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, D Amico, Thomas A., editor, Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, and D Amico, Thomas A., editor

Published
2019

22. Accuracy of a 3-Dimensionally Printed Navigational Template for Localizing Small Pulmonary Nodules:A Noninferiority Randomized Clinical Trial

Author

Zhang, Lei, Wang, Long, Kadeer, Xiermaimaiti, Zeyao, Li, Sun, Xiwen, Sun, Weiyan, She, Yunlang, Xie, Dong, Li, Mu, Zou, Liling, Rocco, Gaetano, Yang, Ping, Chen, Chang, Liu, Chia Chuan, Petersen, René H., Ng, Calvin Sze Hang, Parrish, Scott, Zhang, Yu Shrike, Giordano, Raffaele, Di Tommaso, Luigi, Zhang, Lei, Wang, Long, Kadeer, Xiermaimaiti, Zeyao, Li, Sun, Xiwen, Sun, Weiyan, She, Yunlang, Xie, Dong, Li, Mu, Zou, Liling, Rocco, Gaetano, Yang, Ping, Chen, Chang, Liu, Chia Chuan, Petersen, René H., Ng, Calvin Sze Hang, Parrish, Scott, Zhang, Yu Shrike, Giordano, Raffaele, and Di Tommaso, Luigi

Abstract

Importance: Localization of small lung nodules are challenging because of the difficulty of nodule recognition during video-assisted thoracoscopic surgery. Using 3-dimensional (3-D) printing technology, a navigational template was recently created to assist percutaneous lung nodule localization; however, the efficacy and safety of this template have not yet been evaluated. Objective: To assess the noninferiority of the efficacy and safety of a 3-D-printed navigational template guide for localizing small peripheral lung nodules. Design, Setting, and Participants: This noninferiority randomized clinical trial conducted between October 2016 and October 2017 at Shanghai Pulmonary Hospital, Shanghai, China, compared the safety and precision of lung nodule localization using a template-guided approach vs the conventional computed tomography (CT)-guided approach. In total, 213 surgical candidates with small peripheral lung nodules (<2 cm) were recruited to undergo either CT- or template-guided lung nodule localization. An intention-to-treat analysis was conducted. Interventions: Percutaneous lung nodule localization. Main Outcomes and Measures: The primary outcome was the accuracy of lung nodule localization (localizer deviation), and secondary outcomes were procedural duration, radiation dosage, and complication rate. Results: Of the 200 patients randomized at a ratio of 1:1 to the template- and CT-guided groups, most were women (147 vs 53), body mass index ranged from 15.4 to 37.3, the mean (SD) nodule size was 9.7 (2.9) mm, and the mean distance between the outer edge of target nodule and the pleura was 7.8 (range, 0.0-43.9) mm. In total, 190 patients underwent either CT- or template-guided lung nodule localization and subsequent surgery. Among these patients, localizer deviation did not significantly differ between the template- and CT-guided groups (mean [SD], 8.7 [6.9] vs 9.6 [5.8] mm; P =.36). The mean (SD) procedural durations were 7.4 (3.2) minutes for the t

Published
2019

24. Society for Translational Medicine expert consensus on the use of antibacterial drugs in thoracic surgery

Author

Li, Shanqing, Han, Zhijun, He, Jie, Gao, Shugeng, Liu, Deruo, Liu, Lunxu, He, Jianxing, Huang, Yunchao, Xu, Shidong, Mao, Weimin, Tan, Qunyou, Chen, Chun, Li, Xiaofei, Zhang, Zhu, Jiang, Gening, Xu, Lin, Zhang, Lanjun, Fu, Jianhua, Li, Hui, Wang, Qun, Tan, Lijie, Li, Danqing, Zhou, Qinghua, Fu, Xiangning, Jiang, Zhongmin, Chen, Haiquan, Fang, Wentao, Zhang, Xun, Li, Yin, Tong, Ti, Yu, Zhentao, Liu, Yongyu, Zhi, Xiuyi, Yan, Tiansheng, Zhang, Xingyi, Imperatori, Andrea, Ibrahim, Mohsen, Novoa, Nuria M, Ng, Calvin Sze Hang, Petersen, René Horsleben, Chen, Jin-Shing, Fukuchi, Yoshinosuke, Brunelli, Alessandro, Ismail, Mahmoud, Valverde, Javier Aragón, Rodriguez-Lucas, Carlos, Li, Shanqing, Han, Zhijun, He, Jie, Gao, Shugeng, Liu, Deruo, Liu, Lunxu, He, Jianxing, Huang, Yunchao, Xu, Shidong, Mao, Weimin, Tan, Qunyou, Chen, Chun, Li, Xiaofei, Zhang, Zhu, Jiang, Gening, Xu, Lin, Zhang, Lanjun, Fu, Jianhua, Li, Hui, Wang, Qun, Tan, Lijie, Li, Danqing, Zhou, Qinghua, Fu, Xiangning, Jiang, Zhongmin, Chen, Haiquan, Fang, Wentao, Zhang, Xun, Li, Yin, Tong, Ti, Yu, Zhentao, Liu, Yongyu, Zhi, Xiuyi, Yan, Tiansheng, Zhang, Xingyi, Imperatori, Andrea, Ibrahim, Mohsen, Novoa, Nuria M, Ng, Calvin Sze Hang, Petersen, René Horsleben, Chen, Jin-Shing, Fukuchi, Yoshinosuke, Brunelli, Alessandro, Ismail, Mahmoud, Valverde, Javier Aragón, and Rodriguez-Lucas, Carlos

Published
2018

25. Society for Translational Medicine expert consensus on the use of antibacterial drugs in thoracic surgery

Author

Li, Shanqing, primary, Han, Zhijun, additional, He, Jie, additional, Gao, Shugeng, additional, Liu, Deruo, additional, Liu, Lunxu, additional, He, Jianxing, additional, Huang, Yunchao, additional, Xu, Shidong, additional, Mao, Weimin, additional, Tan, Qunyou, additional, Chen, Chun, additional, Li, Xiaofei, additional, Zhang, Zhu, additional, Jiang, Gening, additional, Xu, Lin, additional, Zhang, Lanjun, additional, Fu, Jianhua, additional, Li, Hui, additional, Wang, Qun, additional, Tan, Lijie, additional, Li, Danqing, additional, Zhou, Qinghua, additional, Fu, Xiangning, additional, Jiang, Zhongmin, additional, Chen, Haiquan, additional, Fang, Wentao, additional, Zhang, Xun, additional, Li, Yin, additional, Tong, Ti, additional, Yu, Zhentao, additional, Liu, Yongyu, additional, Zhi, Xiuyi, additional, Yan, Tiansheng, additional, Zhang, Xingyi, additional, Imperatori, Andrea, additional, Ibrahim, Mohsen, additional, Novoa, Nuria M., additional, Ng, Calvin Sze Hang, additional, Petersen, René Horsleben, additional, Chen, Jin-Shing, additional, Fukuchi, Yoshinosuke, additional, Brunelli, Alessandro, additional, Ismail, Mahmoud, additional, Valverde, Javier Aragón, additional, and Rodriguez-Lucas, Carlos, additional

Published
2018
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29. The Society for Translational Medicine:clinical practice guidelines for mechanical ventilation management for patients undergoing lobectomy

Author

Gao, Shugeng, Zhang, Zhongheng, Brunelli, Alessandro, Chen, Chang, Chen, Chun, Chen, Gang, Chen, Haiquan, Chen, Jin-Shing, Cassivi, Stephen, Chai, Ying, Downs, John B, Fang, Wentao, Fu, Xiangning, Garutti, Martínez I, He, Jianxing, He, Jie, Hu, Jian, Huang, Yunchao, Jiang, Gening, Jiang, Hongjing, Jiang, Zhongmin, Li, Danqing, Li, Gaofeng, Li, Hui, Li, Qiang, Li, Xiaofei, Li, Yin, Li, Zhijun, Liu, Chia-Chuan, Liu, Deruo, Liu, Lunxu, Liu, Yongyi, Ma, Haitao, Mao, Weimin, Mao, Yousheng, Mou, Juwei, Ng, Calvin Sze Hang, Petersen, René H, Qiao, Guibin, Rocco, Gaetano, Ruffini, Erico, Tan, Lijie, Tan, Qunyou, Tong, Tang, Wang, Haidong, Wang, Qun, Wang, Ruwen, Wang, Shumin, Xie, Deyao, Zhang, Lanjun, Zhao, Xuewei, Zhi, Xiuyi, Zhou, Qinghua, Gao, Shugeng, Zhang, Zhongheng, Brunelli, Alessandro, Chen, Chang, Chen, Chun, Chen, Gang, Chen, Haiquan, Chen, Jin-Shing, Cassivi, Stephen, Chai, Ying, Downs, John B, Fang, Wentao, Fu, Xiangning, Garutti, Martínez I, He, Jianxing, He, Jie, Hu, Jian, Huang, Yunchao, Jiang, Gening, Jiang, Hongjing, Jiang, Zhongmin, Li, Danqing, Li, Gaofeng, Li, Hui, Li, Qiang, Li, Xiaofei, Li, Yin, Li, Zhijun, Liu, Chia-Chuan, Liu, Deruo, Liu, Lunxu, Liu, Yongyi, Ma, Haitao, Mao, Weimin, Mao, Yousheng, Mou, Juwei, Ng, Calvin Sze Hang, Petersen, René H, Qiao, Guibin, Rocco, Gaetano, Ruffini, Erico, Tan, Lijie, Tan, Qunyou, Tong, Tang, Wang, Haidong, Wang, Qun, Wang, Ruwen, Wang, Shumin, Xie, Deyao, Zhang, Lanjun, Zhao, Xuewei, Zhi, Xiuyi, and Zhou, Qinghua

Abstract

Patients undergoing lobectomy are at significantly increased risk of lung injury. One-lung ventilation is the most commonly used technique to maintain ventilation and oxygenation during the operation. It is a challenge to choose an appropriate mechanical ventilation strategy to minimize the lung injury and other adverse clinical outcomes. In order to understand the available evidence, a systematic review was conducted including the following topics: (I) protective ventilation (PV); (II) mode of mechanical ventilation [e.g., volume controlled (VCV) versus pressure controlled (PCV)]; (III) use of therapeutic hypercapnia; (IV) use of alveolar recruitment (open-lung) strategy; (V) pre-and post-operative application of positive end expiratory pressure (PEEP); (VI) Inspired Oxygen concentration; (VII) Non-intubated thoracoscopic lobectomy; and (VIII) adjuvant pharmacologic options. The recommendations of class II are non-intubated thoracoscopic lobectomy may be an alternative to conventional one-lung ventilation in selected patients. The recommendations of class IIa are: (I) Therapeutic hypercapnia to maintain a partial pressure of carbon dioxide at 50-70 mmHg is reasonable for patients undergoing pulmonary lobectomy with one-lung ventilation; (II) PV with a tidal volume of 6 mL/kg and PEEP of 5 cmH2O are reasonable methods, based on current evidence; (III) alveolar recruitment [open lung ventilation (OLV)] may be beneficial in patients undergoing lobectomy with one-lung ventilation; (IV) PCV is recommended over VCV for patients undergoing lung resection; (V) pre- and post-operative CPAP can improve short-term oxygenation in patients undergoing lobectomy with one-lung ventilation; (VI) controlled mechanical ventilation with I:E ratio of 1:1 is reasonable in patients undergoing one-lung ventilation; (VII) use of lowest inspired oxygen concentration to maintain satisfactory arterial oxygen saturation is reasonable based on physiologic principles; (VIII) Adjuvant drugs su

Published
2017

31. The Society for Translational Medicine: clinical practice guidelines for mechanical ventilation management for patients undergoing lobectomy

Author

Gao, Shugeng, primary, Zhang, Zhongheng, additional, Brunelli, Alessandro, additional, Chen, Chang, additional, Chen, Chun, additional, Chen, Gang, additional, Chen, Haiquan, additional, Chen, Jin-Shing, additional, Cassivi, Stephen, additional, Chai, Ying, additional, Downs, John B., additional, Fang, Wentao, additional, Fu, Xiangning, additional, Garutti, Martínez I., additional, He, Jianxing, additional, He, Jie, additional, Hu, Jian, additional, Huang, Yunchao, additional, Jiang, Gening, additional, Jiang, Hongjing, additional, Jiang, Zhongmin, additional, Li, Danqing, additional, Li, Gaofeng, additional, Li, Hui, additional, Li, Qiang, additional, Li, Xiaofei, additional, Li, Yin, additional, Li, Zhijun, additional, Liu, Chia-Chuan, additional, Liu, Deruo, additional, Liu, Lunxu, additional, Liu, Yongyi, additional, Ma, Haitao, additional, Mao, Weimin, additional, Mao, Yousheng, additional, Mou, Juwei, additional, Ng, Calvin Sze Hang, additional, Petersen, René H., additional, Qiao, Guibin, additional, Rocco, Gaetano, additional, Ruffini, Erico, additional, Tan, Lijie, additional, Tan, Qunyou, additional, Tong, Tang, additional, Wang, Haidong, additional, Wang, Qun, additional, Wang, Ruwen, additional, Wang, Shumin, additional, Xie, Deyao, additional, Xue, Qi, additional, Xue, Tao, additional, Xu, Lin, additional, Xu, Shidong, additional, Xu, Songtao, additional, Yan, Tiansheng, additional, Yu, Fenglei, additional, Yu, Zhentao, additional, Zhang, Chunfang, additional, Zhang, Lanjun, additional, Zhang, Tao, additional, Zhang, Xun, additional, Zhao, Xiaojing, additional, Zhao, Xuewei, additional, Zhi, Xiuyi, additional, and Zhou, Qinghua, additional

Published
2017
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32. The Society for Translational Medicine: clinical practice guidelines for the postoperative management of chest tube for patients undergoing lobectomy

Author

Gao, Shugeng, primary, Zhang, Zhongheng, additional, Aragón, Javier, additional, Brunelli, Alessandro, additional, Cassivi, Stephen, additional, Chai, Ying, additional, Chen, Chang, additional, Chen, Chun, additional, Chen, Gang, additional, Chen, Haiquan, additional, Chen, Jin-Shing, additional, Cooke, David Tom, additional, Downs, John B., additional, Falcoz, Pierre-Emmanuel, additional, Fang, Wentao, additional, Filosso, Pier Luigi, additional, Fu, Xiangning, additional, Force, Seth D., additional, Garutti, Martínez I., additional, Gonzalez-Rivas, Diego, additional, Gossot, Dominique, additional, Hansen, Henrik Jessen, additional, He, Jianxing, additional, He, Jie, additional, Holbek, Bo Laksáfoss, additional, Hu, Jian, additional, Huang, Yunchao, additional, Ibrahim, Mohsen, additional, Imperatori, Andrea, additional, Ismail, Mahmoud, additional, Jiang, Gening, additional, Jiang, Hongjing, additional, Jiang, Zhongmin, additional, Kim, Hyun Koo, additional, Li, Danqing, additional, Li, Gaofeng, additional, Li, Hui, additional, Li, Qiang, additional, Li, Xiaofei, additional, Li, Yin, additional, Li, Zhijun, additional, Lim, Eric, additional, Liu, Chia-Chuan, additional, Liu, Deruo, additional, Liu, Lunxu, additional, Liu, Yongyi, additional, Lobdell, Kevin W., additional, Ma, Haitao, additional, Mao, Weimin, additional, Mao, Yousheng, additional, Mou, Juwei, additional, Ng, Calvin Sze Hang, additional, Novoa, Nuria M., additional, Petersen, René H., additional, Oizumi, Hiroyuki, additional, Papagiannopoulos, Kostas, additional, Pompili, Cecilia, additional, Qiao, Guibin, additional, Refai, Majed, additional, Rocco, Gaetano, additional, Ruffini, Erico, additional, Salati, Michele, additional, Seguin-Givelet, Agathe, additional, Sihoe, Alan Dart Loon, additional, Tan, Lijie, additional, Tan, Qunyou, additional, Tong, Tang, additional, Tsakiridis, Kosmas, additional, Venuta, Federico, additional, Veronesi, Giulia, additional, Villamizar, Nestor, additional, Wang, Haidong, additional, Wang, Qun, additional, Wang, Ruwen, additional, Wang, Shumin, additional, Wright, Gavin M., additional, Xie, Deyao, additional, Xue, Qi, additional, Xue, Tao, additional, Xu, Lin, additional, Xu, Shidong, additional, Xu, Songtao, additional, Yan, Tiansheng, additional, Yu, Fenglei, additional, Yu, Zhentao, additional, Zhang, Chunfang, additional, Zhang, Lanjun, additional, Zhang, Tao, additional, Zhang, Xun, additional, Zhao, Xiaojing, additional, Zhao, Xuewei, additional, Zhi, Xiuyi, additional, and Zhou, Qinghua, additional

Published
2017
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33. EGFRmutation exists in squamous cell lung carcinoma

Author

Cheung, Alvin Ho-Kwan, Tong, Joanna Hung-Man, Chung, Lau-Ying, Chau, Shuk-Ling, Ng, Calvin Sze-Hang, Wan, Innes Y.P., and To, Ka-Fai

Abstract

Whether EGFRmutation occurs in lung squamous cell carcinoma (SCC) remains a controversial issue. Although numerous trials have shown positive response to tyrosine kinase inhibitors in SCC, these observations have not been well correlated with presence or absence of EGFRmutation. A complicating issue is that adenosquamous carcinoma, a mimic of SCC, frequently harbours EGFRmutations. We evaluated the EGFRmutation status of 191 cases initially diagnosed as SCC of lung origin in years 2000–2011, and performed a panel of markers including p40, p63, CK5/6, TTF-1, mucicarmine on the tissue microarray or tissue blocks from each case, to ascertain the squamous differentiation of each case. Four cases were found to have EGFRmutations, with three showing typical squamous morphological features and immunohistochemical profile on all available tumour blocks, and one reclassified as adenosquamous carcinoma. Mixed responses were noted for two of the patients with EGFR-mutated SCC treated with tyrosine kinase inhibitors. In conclusion, we report that a small subset of rigorously proven SCC harbours EGFRmutation. It also appears in our cohort that EGFR-mutated tumours, in the context of SCC, may have relatively poor response to tyrosine kinase inhibitors.

Published
2020
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34. Accuracy of a 3-Dimensionally Printed Navigational Template for Localizing Small Pulmonary Nodules: A Noninferiority Randomized Clinical Trial.

Author

Zhang, Lei, Wang, Long, Kadeer, Xiermaimaiti, Zeyao, Li, Sun, Xiwen, Sun, Weiyan, She, Yunlang, Xie, Dong, Li, Mu, Zou, Liling, Rocco, Gaetano, Yang, Ping, Chen, Chang, Liu, Chia-Chuan, Petersen, René H., Ng, Calvin Sze Hang, Parrish, Scott, Zhang, Yu Shrike, Giordano, Raffaele, and di Tommaso, Luigi

Published
2019
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37. Development of 3D VATS

Author

Liu, Jun, Li, Jingpei, Wang, Yidong, Lai, Fengling, Wang, Wei, Peng, Guilin, Guo, Zhihua, He, Jiaxi, Cui, Fei, Li, Shuben, He, Jianxing, Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, and D’Amico, Thomas A., editor

Published
2019
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42. Troubleshooting: Management of Bleeding

Author

Prado, Ricardo Fernandez, Granados, Juan Pablo Ovalle, Vago, Luis Fernandez, Costa, Eva Maria Fieira, De La Morena, Marina Paradela, Roel, Maria Delgado, Gonzalez-Rivas, Diego, De La Torre Bravos, Mercedes, Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, and D’Amico, Thomas A., editor

Published
2019
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47. Left Upper Lobectomy

Author

Liu, Chengwu, Liu, Lunxu, Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, and D’Amico, Thomas A., editor

Published
2019
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48. Sleeve Resection

Author

Kim, Hyun Koo, Han, Kook Nam, Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, and D’Amico, Thomas A., editor

Published
2019
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50. Uniportal Lymphadenectomy

Author

Delgado Roel, Maria, Fieira Costa, Eva, Paradela De La Morena, Marina, Gonzalez-Rivas, Diego, Fernandez Prado, Ricardo, Ovalle Granados, Juan Pablo, De La Torre Bravos, Mercedes, Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, and D’Amico, Thomas A., editor

Published
2019
Full Text
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