30 results on '"Ngabo, Didier"'
Search Results
2. Refinement of an ovine-based immunoglobulin therapy against SARS-CoV-2, with comparison of whole IgG versus F(ab′)2 fragments
- Author
-
Findlay-Wilson, Stephen, Easterbrook, Linda, Smith, Sandra, Pope, Neville, Aldridge, Matthew, Humphries, Gareth, Schuhmann, Holger, Ngabo, Didier, Rayner, Emma, Otter, Ashley, Coleman, Thomas, Hicks, Bethany, Halkerston, Rachel, Apostolakis, Kostis, Taylor, Stephen, Fotheringham, Susan, Horton, Amanda, CanoCejas, Irene, Wand, Matthew, Tree, Julia A., Sutton, Mark, Graham, Victoria, Hewson, Roger, and Dowall, Stuart
- Published
- 2023
- Full Text
- View/download PDF
3. Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
- Author
-
Salguero, Francisco J., White, Andrew D., Slack, Gillian S., Fotheringham, Susan A., Bewley, Kevin R., Gooch, Karen E., Longet, Stephanie, Humphries, Holly E., Watson, Robert J., Hunter, Laura, Ryan, Kathryn A., Hall, Yper, Sibley, Laura, Sarfas, Charlotte, Allen, Lauren, Aram, Marilyn, Brunt, Emily, Brown, Phillip, Buttigieg, Karen R., Cavell, Breeze E., Cobb, Rebecca, Coombes, Naomi S., Darby, Alistair, Daykin-Pont, Owen, Elmore, Michael J., Garcia-Dorival, Isabel, Gkolfinos, Konstantinos, Godwin, Kerry J., Gouriet, Jade, Halkerston, Rachel, Harris, Debbie J., Hender, Thomas, Ho, Catherine M. K., Kennard, Chelsea L., Knott, Daniel, Leung, Stephanie, Lucas, Vanessa, Mabbutt, Adam, Morrison, Alexandra L., Nelson, Charlotte, Ngabo, Didier, Paterson, Jemma, Penn, Elizabeth J., Pullan, Steve, Taylor, Irene, Tipton, Tom, Thomas, Stephen, Tree, Julia A., Turner, Carrie, Vamos, Edith, Wand, Nadina, Wiblin, Nathan R., Charlton, Sue, Dong, Xiaofeng, Hallis, Bassam, Pearson, Geoffrey, Rayner, Emma L., Nicholson, Andrew G., Funnell, Simon G., Hiscox, Julian A., Dennis, Mike J., Gleeson, Fergus V., Sharpe, Sally, and Carroll, Miles W.
- Published
- 2021
- Full Text
- View/download PDF
4. A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
- Author
-
Huo, Jiandong, Mikolajek, Halina, Le Bas, Audrey, Clark, Jordan J., Sharma, Parul, Kipar, Anja, Dormon, Joshua, Norman, Chelsea, Weckener, Miriam, Clare, Daniel K., Harrison, Peter J., Tree, Julia A., Buttigieg, Karen R., Salguero, Francisco J., Watson, Robert, Knott, Daniel, Carnell, Oliver, Ngabo, Didier, Elmore, Michael J., Fotheringham, Susan, Harding, Adam, Moynié, Lucile, Ward, Philip N., Dumoux, Maud, Prince, Tessa, Hall, Yper, Hiscox, Julian A., Owen, Andrew, James, William, Carroll, Miles W., Stewart, James P., Naismith, James H., and Owens, Raymond J.
- Published
- 2021
- Full Text
- View/download PDF
5. ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
- Author
-
Lambe, Teresa, Spencer, Alexandra J., Thomas, Kelly M., Gooch, Karen E., Thomas, Stephen, White, Andrew D., Humphries, Holly E., Wright, Daniel, Belij-Rammerstorfer, Sandra, Thakur, Nazia, Conceicao, Carina, Watson, Robert, Alden, Leonie, Allen, Lauren, Aram, Marilyn, Bewley, Kevin R., Brunt, Emily, Brown, Phillip, Cavell, Breeze E., Cobb, Rebecca, Fotheringham, Susan A., Gilbride, Ciaran, Harris, Debbie J., Ho, Catherine M. K., Hunter, Laura, Kennard, Chelsea L., Leung, Stephanie, Lucas, Vanessa, Ngabo, Didier, Ryan, Kathryn A., Sharpe, Hannah, Sarfas, Charlotte, Sibley, Laura, Slack, Gillian S., Ulaszewska, Marta, Wand, Nadina, Wiblin, Nathan R., Gleeson, Fergus V., Bailey, Dalan, Sharpe, Sally, Charlton, Sue, Salguero, Francisco J., Carroll, Miles W., and Gilbert, Sarah C.
- Published
- 2021
- Full Text
- View/download PDF
6. Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
- Author
-
Ryan, Kathryn A., Bewley, Kevin R., Fotheringham, Susan A., Slack, Gillian S., Brown, Phillip, Hall, Yper, Wand, Nadina I., Marriott, Anthony C., Cavell, Breeze E., Tree, Julia A., Allen, Lauren, Aram, Marilyn J., Bean, Thomas J., Brunt, Emily, Buttigieg, Karen R., Carter, Daniel P., Cobb, Rebecca, Coombes, Naomi S., Findlay-Wilson, Steve J., Godwin, Kerry J., Gooch, Karen E., Gouriet, Jade, Halkerston, Rachel, Harris, Debbie J., Hender, Thomas H., Humphries, Holly E., Hunter, Laura, Ho, Catherine M. K., Kennard, Chelsea L., Leung, Stephanie, Longet, Stephanie, Ngabo, Didier, Osman, Karen L., Paterson, Jemma, Penn, Elizabeth J., Pullan, Steven T., Rayner, Emma, Skinner, Oliver, Steeds, Kimberley, Taylor, Irene, Tipton, Tom, Thomas, Stephen, Turner, Carrie, Watson, Robert J., Wiblin, Nathan R., Charlton, Sue, Hallis, Bassam, Hiscox, Julian A., Funnell, Simon, Dennis, Mike J., Whittaker, Catherine J., Catton, Michael G., Druce, Julian, Salguero, Francisco J., and Carroll, Miles W.
- Published
- 2021
- Full Text
- View/download PDF
7. The Omicron Sub-Variant BA.4 Displays a Remarkable Lack of Clinical Signs in a Golden Syrian Hamster Model of SARS-CoV-2 Infection
- Author
-
Davies, Elizabeth R., primary, Ryan, Kathryn A., additional, Bewley, Kevin R., additional, Coombes, Naomi S., additional, Salguero, Francisco J., additional, Carnell, Oliver T., additional, Biddlecombe, Sarah, additional, Charlton, Michael, additional, Challis, Amy, additional, Cross, Eleanor S., additional, Handley, Alastair, additional, Ngabo, Didier, additional, Weldon, Thomas M., additional, Hall, Yper, additional, and Funnell, Simon G. P., additional
- Published
- 2023
- Full Text
- View/download PDF
8. Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variant
- Author
-
Ryan, Kathryn A., primary, Bewley, Kevin R., additional, Watson, Robert J., additional, Burton, Christopher, additional, Carnell, Oliver, additional, Cavell, Breeze E., additional, Challis, Amy, additional, Coombes, Naomi S., additional, Davies, Elizabeth R., additional, Edun-Huges, Jack, additional, Emery, Kirsty, additional, Fell, Rachel, additional, Fotheringham, Susan A., additional, Gooch, Karen E., additional, Gowan, Kathryn, additional, Handley, Alastair, additional, Harris, Debbie J., additional, Hesp, Richard, additional, Hunter, Laura, additional, Humphreys, Richard, additional, Johnson, Rachel, additional, Kennard, Chelsea, additional, Knott, Daniel, additional, Lister, Sian, additional, Morley, Daniel, additional, Ngabo, Didier, additional, Osman, Karen L., additional, Paterson, Jemma, additional, Penn, Elizabeth J., additional, Pullan, Steven T., additional, Richards, Kevin S., additional, Summers, Sian, additional, Thomas, Stephen R., additional, Weldon, Thomas, additional, Wiblin, Nathan R., additional, Rayner, Emma L., additional, Vipond, Richard T., additional, Hallis, Bassam, additional, Salguero, Francisco J., additional, Funnell, Simon G. P., additional, and Hall, Yper, additional
- Published
- 2023
- Full Text
- View/download PDF
9. SARS-CoV-2 Disease Severity in the Golden Syrian Hamster Model of Infection Is Related to the Volume of Intranasal Inoculum
- Author
-
Handley, Alastair, primary, Ryan, Kathryn A., additional, Davies, Elizabeth R., additional, Bewley, Kevin R., additional, Carnell, Oliver T., additional, Challis, Amy, additional, Coombes, Naomi S., additional, Fotheringham, Susan A., additional, Gooch, Karen E., additional, Charlton, Michael, additional, Harris, Debbie J., additional, Kennard, Chelsea, additional, Ngabo, Didier, additional, Weldon, Thomas M., additional, Salguero, Francisco J., additional, Funnell, Simon G. P., additional, and Hall, Yper, additional
- Published
- 2023
- Full Text
- View/download PDF
10. Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015
- Author
-
Kerber, Romy, Krumkamp, Ralf, Diallo, Boubacar, Jaeger, Anna, Rudolf, Martin, Lanini, Simone, Bore, Joseph Akoi, Koundouno, Fara Raymond, Becker-Ziaja, Beate, Fleischmann, Erna, Stoecker, Kilian, Meschi, Silvia, Mély, Stéphane, Newman, Edmund N. C., Carletti, Fabrizio, Portmann, Jasmine, Korva, Misa, Wolff, Svenja, Molkenthin, Peter, Kis, Zoltan, Kelterbaum, Anne, Bocquin, Anne, Strecker, Thomas, Fizet, Alexandra, Castilletti, Concetta, Schudt, Gordian, Ottowell, Lisa, Kurth, Andreas, Atkinson, Barry, Badusche, Marlis, Cannas, Angela, Pallasch, Elisa, Bosworth, Andrew, Yue, Constanze, Pályi, Bernadett, Ellerbrok, Heinz, Kohl, Claudia, Oestereich, Lisa, Logue, Christopher H., Lüdtke, Anja, Richter, Martin, Ngabo, Didier, Borremans, Benny, Becker, Dirk, Gryseels, Sophie, Abdellati, Saïd, Vermoesen, Tine, Kuisma, Eeva, Kraus, Annette, Liedigk, Britta, Maes, Piet, Thom, Ruth, Duraffour, Sophie, Diederich, Sandra, Hinzmann, Julia, Afrough, Babak, Repits, Johanna, Mertens, Marc, Vitoriano, Inês, Bah, Amadou, Sachse, Andreas, Boettcher, Jan Peter, Wurr, Stephanie, Bockholt, Sabrina, Nitsche, Andreas, Županc, Tatjana Avšič, Strasser, Marc, Ippolito, Giuseppe, Becker, Stephan, Raoul, Herve, Carroll, Miles W., De Clerck, Hilde, Van Herp, Michel, Sprecher, Armand, Koivogui, Lamine, Magassouba, N'Faly, Keïta, Sakoba, Drury, Patrick, Gurry, Cèline, Formenty, Pierre, May, Jürgen, Gabriel, Martin, Wölfel, Roman, Günther, Stephan, and Di Caro, Antonino
- Published
- 2016
11. Refinement of an ovine-based immunoglobulin therapy against SARS-CoV-2, with comparison of whole IgG versus F(ab′)2 fragments.
- Author
-
Findlay-Wilson, Stephen, Easterbrook, Linda, Smith, Sandra, Pope, Neville, Aldridge, Matthew, Humphries, Gareth, Schuhmann, Holger, Ngabo, Didier, Rayner, Emma, Otter, Ashley, Coleman, Thomas, Hicks, Bethany, Halkerston, Rachel, Apostolakis, Kostis, Taylor, Stephen, Fotheringham, Susan, Horton, Amanda, CanoCejas, Irene, Wand, Matthew, and Tree, Julia A.
- Subjects
SEROTHERAPY ,SARS-CoV-2 ,IMMUNOGLOBULIN G ,SARS-CoV-2 Omicron variant ,RECOMBINANT proteins - Abstract
The development of new therapies against SARS-CoV-2 is required to extend the toolkit of intervention strategies to combat the global pandemic. In this study, hyperimmune plasma from sheep immunised with whole spike SARS-CoV-2 recombinant protein has been used to generate candidate products. In addition to purified IgG, we have refined candidate therapies by removing non-specific IgG via affinity binding along with fragmentation to eliminate the Fc region to create F(ab′)
2 fragments. These preparations were evaluated for in vitro activity and demonstrated to be strongly neutralising against a range of SARS-CoV-2 strains, including Omicron B2.2. In addition, their protection against disease manifestations and viral loads were assessed using a hamster SARS-CoV-2 infection model. Results demonstrated protective effects of both IgG and F(ab′)2 , with the latter requiring sequential dosing to maintain in vivo activity due to rapid clearance from the circulation. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
12. Unique human immune signature of Ebola virus disease in Guinea
- Author
-
Ruibal, Paula, Oestereich, Lisa, Ldtke, Anja, Becker-Ziaja, Beate, Wozniak, David M., Kerber, Romy, Korva, Mia, Cabeza-Cabrerizo, Mar, Bore, Joseph A., Koundouno, Fara Raymond, Duraffour, Sophie, Weller, Romy, Thorenz, Anja, Cimini, Eleonora, Viola, Domenico, Agrati, Chiara, Repits, Johanna, Afrough, Babak, Cowley, Lauren A., Ngabo, Didier, Hinzmann, Julia, Mertens, Marc, Vitoriano, Ins, Logue, Christopher H., Boettcher, Jan Peter, Pallasch, Elisa, Sachse, Andreas, Bah, Amadou, Nitzsche, Katja, Kuisma, Eeva, Michel, Janine, Holm, Tobias, Zekeng, Elsa-Gayle, Garca-Dorival, Isabel, Wlfel, Roman, Stoecker, Kilian, Fleischmann, Erna, Strecker, Thomas, Di Caro, Antonino, Avi-upanc, Tatjana, Kurth, Andreas, Meschi, Silvia, Mly, Stephane, Newman, Edmund, Bocquin, Anne, Kis, Zoltan, Kelterbaum, Anne, Molkenthin, Peter, Carletti, Fabrizio, Portmann, Jasmine, Wolff, Svenja, Castilletti, Concetta, Schudt, Gordian, Fizet, Alexandra, Ottowell, Lisa J., Herker, Eva, Jacobs, Thomas, Kretschmer, Birte, Severi, Ettore, Ouedraogo, Nobila, Lago, Mar, Negredo, Anabel, Franco, Leticia, Anda, Pedro, Schmiedel, Stefan, Kreuels, Benno, Wichmann, Dominic, Addo, Marylyn M., Lohse, Ansgar W., De Clerck, Hilde, Nanclares, Carolina, Jonckheere, Sylvie, Van Herp, Michel, Sprecher, Armand, Xiaojiang, Gao, Carrington, Mary, Miranda, Osvaldo, Castro, Carlos M., Gabriel, Martin, Drury, Patrick, Formenty, Pierre, Diallo, Boubacar, Koivogui, Lamine, Magassouba, NFaly, Carroll, Miles W., Gnther, Stephan, and Muoz-Fontela, Csar
- Subjects
Ebola hemorrhagic fever -- Physiological aspects ,Medical research ,Immune response -- Research ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): Paula Ruibal [1, 2, 3, 4]; Lisa Oestereich [2, 3, 4]; Anja Ldtke [1, 2, 3, 4]; Beate Becker-Ziaja [2, 3, 4]; David M. Wozniak [2, 3, 4]; Romy [...]
- Published
- 2016
- Full Text
- View/download PDF
13. Infection‐competent monkeypox virus contamination identified in domestic settings following an imported case of monkeypox into the UK
- Author
-
Atkinson, Barry, primary, Burton, Christopher, additional, Pottage, Thomas, additional, Thompson, Katy‐Anne, additional, Ngabo, Didier, additional, Crook, Ant, additional, Pitman, James, additional, Summers, Sian, additional, Lewandowski, Kuiama, additional, Furneaux, Jenna, additional, Davies, Katherine, additional, Brooks, Timothy, additional, Bennett, Allan M., additional, and Richards, Kevin S., additional
- Published
- 2022
- Full Text
- View/download PDF
14. Microbial Aerosols Generated from Standard Microbiological Laboratory Procedures
- Author
-
Pottage, Thomas, primary, Ngabo, Didier, additional, Parks, Simon, additional, Hookway, Helen, additional, Verlander, Neville Q., additional, Kojima, Kazunobu, additional, and Bennett, Allan M., additional
- Published
- 2022
- Full Text
- View/download PDF
15. Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
- Author
-
Carroll, Miles W., Matthews, David A., Hiscox, Julian A., Elmore, Michael J., Pollakis, Georgios, Rambaut, Andrew, Hewson, Roger, García-Dorival, Isabel, Bore, Joseph Akoi, Koundouno, Raymond, Abdellati, Saïd, Afrough, Babak, Aiyepada, John, Akhilomen, Patience, Asogun, Danny, Atkinson, Barry, Badusche, Marlis, Bah, Amadou, Bate, Simon, Baumann, Jan, Becker, Dirk, Becker-Ziaja, Beate, Bocquin, Anne, Borremans, Benny, Bosworth, Andrew, Boettcher, Jan Peter, Cannas, Angela, Carletti, Fabrizio, Castilletti, Concetta, Clark, Simon, Colavita, Francesca, Diederich, Sandra, Donatus, Adomeh, Duraffour, Sophie, Ehichioya, Deborah, Ellerbrok, Heinz, Fernandez-Garcia, Maria Dolores, Fizet, Alexandra, Fleischmann, Erna, Gryseels, Sophie, Hermelink, Antje, Hinzmann, Julia, Hopf-Guevara, Ute, Ighodalo, Yemisi, Jameson, Lisa, Kelterbaum, Anne, Kis, Zoltan, Kloth, Stefan, Kohl, Claudia, Korva, Miša, Kraus, Annette, Kuisma, Eeva, Kurth, Andreas, Liedigk, Britta, Logue, Christopher H., Lüdtke, Anja, Maes, Piet, McCowen, James, Mély, Stéphane, Mertens, Marc, Meschi, Silvia, Meyer, Benjamin, Michel, Janine, Molkenthin, Peter, Muñoz-Fontela, César, Muth, Doreen, Newman, Edmund N. C., Ngabo, Didier, Oestereich, Lisa, Okosun, Jennifer, Olokor, Thomas, Omiunu, Racheal, Omomoh, Emmanuel, Pallasch, Elisa, Pályi, Bernadett, Portmann, Jasmine, Pottage, Thomas, Pratt, Catherine, Priesnitz, Simone, Quartu, Serena, Rappe, Julie, Repits, Johanna, Richter, Martin, Rudolf, Martin, Sachse, Andreas, Schmidt, Kristina Maria, Schudt, Gordian, Strecker, Thomas, Thom, Ruth, Thomas, Stephen, Tobin, Ekaete, Tolley, Howard, Trautner, Jochen, Vermoesen, Tine, Vitoriano, Inês, Wagner, Matthias, Wolff, Svenja, Yue, Constanze, Capobianchi, Maria Rosaria, Kretschmer, Birte, Hall, Yper, Kenny, John G., Rickett, Natasha Y., Dudas, Gytis, Coltart, Cordelia E. M., Kerber, Romy, Steer, Damien, Wright, Callum, Senyah, Francis, Keita, Sakoba, Drury, Patrick, Diallo, Boubacar, de Clerck, Hilde, Van Herp, Michel, Sprecher, Armand, Traore, Alexis, Diakite, Mandiou, Konde, Mandy Kader, Koivogui, Lamine, Magassouba, N’Faly, Avšič-Županc, Tatjana, Nitsche, Andreas, Strasser, Marc, Ippolito, Giuseppe, Becker, Stephan, Stoecker, Kilian, Gabriel, Martin, Raoul, Hervé, Di Caro, Antonino, Wölfel, Roman, Formenty, Pierre, and Günther, Stephan
- Published
- 2015
- Full Text
- View/download PDF
16. Activity of a Carbohydrate-Binding Module Therapy, Neumifil, against SARS-CoV-2 Disease in a Hamster Model of Infection
- Author
-
Fell, Rachel, primary, Potter, Jane A., additional, Yuille, Samantha, additional, Salguero, Franscisco J., additional, Watson, Robert, additional, Ngabo, Didier, additional, Gooch, Karen, additional, Hewson, Roger, additional, Howat, David, additional, and Dowall, Stuart, additional
- Published
- 2022
- Full Text
- View/download PDF
17. Development of a cost-effective ovine antibody-based therapy against SARS-CoV-2 infection and contribution of antibodies specific to the spike subunit proteins
- Author
-
Findlay-Wilson, Stephen, primary, Easterbrook, Linda, additional, Smith, Sandra, additional, Pope, Neville, additional, Humphries, Gareth, additional, Schuhmann, Holger, additional, Ngabo, Didier, additional, Rayner, Emma, additional, Otter, Ashley David, additional, Coleman, Tom, additional, Hicks, Bethany, additional, Graham, Victoria Anne, additional, Halkerston, Rachel, additional, Apostolakis, Kostis, additional, Taylor, Stephen, additional, Fotheringham, Susan, additional, Horton, Amanda, additional, Tree, Julia Anne, additional, Wand, Matthew, additional, Hewson, Roger, additional, and Dowall, Stuart David, additional
- Published
- 2022
- Full Text
- View/download PDF
18. Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant
- Author
-
Ryan, Kathryn A., primary, Watson, Robert J., additional, Bewley, Kevin R., additional, Burton, Christopher, additional, Carnell, Oliver, additional, Cavell, Breeze E., additional, Challis, Amy, additional, Coombes, Naomi S., additional, Emery, Kirsty, additional, Fell, Rachel, additional, Fotheringham, Susan A., additional, Gooch, Karen E., additional, Gowan, Kathryn, additional, Handley, Alastair, additional, Harris, Debbie J., additional, Humphreys, Richard, additional, Johnson, Rachel, additional, Knott, Daniel, additional, Lister, Sian, additional, Morley, Daniel, additional, Ngabo, Didier, additional, Osman, Karen L., additional, Paterson, Jemma, additional, Penn, Elizabeth J., additional, Pullan, Steven T., additional, Richards, Kevin S., additional, Shaik, Imam, additional, Summers, Sian, additional, Thomas, Stephen R., additional, Weldon, Thomas, additional, Wiblin, Nathan R., additional, Vipond, Richard, additional, Hallis, Bassam, additional, Funnell, Simon G. P., additional, and Hall, Yper, additional
- Published
- 2021
- Full Text
- View/download PDF
19. Real-time, portable genome sequencing for Ebola surveillance
- Author
-
Quick, Joshua, Loman, Nicholas J., Duraffour, Sophie, Simpson, Jared T., Severi, Ettore, Cowley, Lauren, Bore, Joseph Akoi, Koundouno, Raymond, Dudas, Gytis, Mikhail, Amy, Ouédraogo, Nobila, Afrough, Babak, Bah, Amadou, Baum, Jonathan H. J., Becker-Ziaja, Beate, Boettcher, Jan Peter, Cabeza-Cabrerizo, Mar, Camino-Sánchez, Álvaro, Carter, Lisa L., Doerrbecker, Juliane, Enkirch, Theresa, Dorival, Isabel García-, Hetzelt, Nicole, Hinzmann, Julia, Holm, Tobias, Kafetzopoulou, Liana Eleni, Koropogui, Michel, Kosgey, Abigael, Kuisma, Eeva, Logue, Christopher H., Mazzarelli, Antonio, Meisel, Sarah, Mertens, Marc, Michel, Janine, Ngabo, Didier, Nitzsche, Katja, Pallasch, Elisa, Patrono, Livia Victoria, Portmann, Jasmine, Repits, Johanna Gabriella, Rickett, Natasha Y., Sachse, Andreas, Singethan, Katrin, Vitoriano, Inês, Yemanaberhan, Rahel L., Zekeng, Elsa G., Racine, Trina, Bello, Alexander, Sall, Amadou Alpha, Faye, Ousmane, Faye, Oumar, Magassouba, NʼFaly, Williams, Cecelia V., Amburgey, Victoria, Winona, Linda, Davis, Emily, Gerlach, Jon, Washington, Frank, Monteil, Vanessa, Jourdain, Marine, Bererd, Marion, Camara, Alimou, Somlare, Hermann, Camara, Abdoulaye, Gerard, Marianne, Bado, Guillaume, Baillet, Bernard, Delaune, Déborah, Nebie, Koumpingnin Yacouba, Diarra, Abdoulaye, Savane, Yacouba, Pallawo, Raymond Bernard, Gutierrez, Giovanna Jaramillo, Milhano, Natacha, Roger, Isabelle, Williams, Christopher J., Yattara, Facinet, Lewandowski, Kuiama, Taylor, James, Rachwal, Phillip, Turner, Daniel J., Pollakis, Georgios, Hiscox, Julian A., Matthews, David A., Shea, Matthew K. Oʼ, Johnston, Andrew McD., Wilson, Duncan, Hutley, Emma, Smit, Erasmus, Di Caro, Antonino, Wölfel, Roman, Stoecker, Kilian, Fleischmann, Erna, Gabriel, Martin, Weller, Simon A., Koivogui, Lamine, Diallo, Boubacar, Keïta, Sakoba, Rambaut, Andrew, Formenty, Pierre, Günther, Stephan, and Carroll, Miles W.
- Published
- 2016
- Full Text
- View/download PDF
20. A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
- Author
-
Huo, Jiandong, primary, Mikolajek, Halina, additional, Bas, Audrey Le, additional, Clark, Jordan, additional, Sharma, Parul, additional, Kipar, Anja, additional, Dormon, Joshua, additional, Norman, Chelsea, additional, Weckener, Miriam, additional, Clare, Daniel, additional, Harrison, Peter, additional, Tree, Julia, additional, Buttigieg, Karen, additional, Salguero, Francisco, additional, Watson, Robert, additional, Knott, Daniel, additional, Carnell, Oliver, additional, Ngabo, Didier, additional, Elmore, Michael, additional, Fotheringham, Susan, additional, Harding, Adam, additional, Ward, Philip, additional, Moynie, Lucile, additional, Dumoux, Maud, additional, Hall, Yper, additional, Hiscox, Julian, additional, Owen, Andrew, additional, James, William, additional, Carroll, Miles, additional, Stewart, James, additional, Naismith, James, additional, and Owens, Raymond, additional
- Published
- 2021
- Full Text
- View/download PDF
21. ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
- Author
-
Lambe, Teresa, primary, Spencer, Alexandra, additional, Thomas, Kelly, additional, Thomas, Stephen, additional, White, Andrew, additional, Humphries, Holly, additional, Wright, Daniel, additional, Thakur, Nazia, additional, Conceicao, Carina, additional, Alden, Leonie, additional, Allen, Lauren, additional, Aram, Marilyn, additional, Bewley, Kevin, additional, Brunt, Emily, additional, Brown, Phillip, additional, Cavell, Breeze, additional, Cobb, Rebecca, additional, Fotheringham, Susan, additional, Gilbride, Ciaran, additional, Harris, Debbie, additional, Ho, Catherine, additional, Hunter, Laura, additional, Kennard, Chelsea, additional, Leung, Stephanie, additional, Lucas, V, additional, Ngabo, Didier, additional, Ryan, Kathryn, additional, Sharpe, Hannah, additional, Sarfas, Charlotte, additional, Sibley, Laura, additional, Slack, Gillian, additional, Ulaszewska, Marta, additional, wand, Nadina, additional, Wiblin, Nathan, additional, Gleeson, Fergus, additional, Bailey, Dalan, additional, Sharpe, Sally, additional, Charlton, Sue, additional, Salguero, Francisco, additional, Carroll, Miles, additional, and Gilbert, Sarah, additional
- Published
- 2021
- Full Text
- View/download PDF
22. Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model
- Author
-
Proud, Pamela C., primary, Tsitoura, Daphne, additional, Watson, Robert J., additional, Chua, Brendon Y., additional, Aram, Marilyn J., additional, Bewley, Kevin R., additional, Cavell, Breeze E., additional, Cobb, Rebecca, additional, Dowall, Stuart, additional, Fotheringham, Susan A., additional, Ho, Catherine M.K., additional, Lucas, Vanessa, additional, Ngabo, Didier, additional, Rayner, Emma, additional, Ryan, Kathryn A., additional, Slack, Gillian S., additional, Thomas, Stephen, additional, Wand, Nadina I., additional, Yeates, Paul, additional, Demaison, Christophe, additional, Zeng, Weiguang, additional, Holmes, Ian, additional, Jackson, David C., additional, Bartlett, Nathan W., additional, Mercuri, Francesca, additional, and Carroll, Miles W., additional
- Published
- 2021
- Full Text
- View/download PDF
23. mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection
- Author
-
Rauch, Susanne, primary, Gooch, Karen, additional, Hall, Yper, additional, Salguero, Francisco J., additional, Dennis, Mike J., additional, Gleeson, Fergus V., additional, Harris, Debbie, additional, Ho, Catherine, additional, Humphries, Holly E., additional, Longet, Stephanie, additional, Ngabo, Didier, additional, Paterson, Jemma, additional, Rayner, Emma L., additional, Ryan, Kathryn A., additional, Sharpe, Sally, additional, Watson, Robert J., additional, Mueller, Stefan O., additional, Petsch, Benjamin, additional, and Carroll, Miles W., additional
- Published
- 2020
- Full Text
- View/download PDF
24. Prophylactic intranasal administration of a TLR2 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model
- Author
-
Proud, Pamela C., primary, Tsitoura, Daphne, additional, Watson, Robert J., additional, Chua, Brendon Y, additional, Aram, Marilyn J., additional, Bewley, Kevin R., additional, Cavell, Breeze E., additional, Cobb, Rebecca, additional, Dowall, Stuart, additional, Fotheringham, Susan A., additional, Ho, Catherine M. K., additional, Lucas, Vanessa, additional, Ngabo, Didier, additional, Rayner, Emma, additional, Ryan, Kathryn A., additional, Slack, Gillian S., additional, Thomas, Stephen, additional, Wand, Nadina I., additional, Yeates, Paul, additional, Demaison, Christophe, additional, Jackson, David C., additional, Bartlett, Nathan W., additional, Mercuri, Francesca, additional, and Carroll, Miles W., additional
- Published
- 2020
- Full Text
- View/download PDF
25. Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19
- Author
-
Salguero, Francisco J., primary, White, Andrew D., additional, Slack, Gillian S., additional, Fotheringham, Susan A., additional, Bewley, Kevin R., additional, Gooch, Karen E., additional, Longet, Stephanie, additional, Humphries, Holly E., additional, Watson, Robert J., additional, Hunter, Laura, additional, Ryan, Kathryn A., additional, Hall, Yper, additional, Sibley, Laura, additional, Sarfas, Charlotte, additional, Allen, Lauren, additional, Aram, Marilyn, additional, Brunt, Emily, additional, Brown, Phillip, additional, Buttigieg, Karen R., additional, Cavell, Breeze E., additional, Cobb, Rebecca, additional, Coombes, Naomi S., additional, Daykin-Pont, Owen, additional, Elmore, Michael J., additional, Gkolfinos, Konstantinos, additional, Godwin, Kerry J., additional, Gouriet, Jade, additional, Halkerston, Rachel, additional, Harris, Debbie J., additional, Hender, Thomas, additional, Ho, Catherine M.K., additional, Kennard, Chelsea L., additional, Knott, Daniel, additional, Leung, Stephanie, additional, Lucas, Vanessa, additional, Mabbutt, Adam, additional, Morrison, Alexandra L., additional, Ngabo, Didier, additional, Paterson, Jemma, additional, Penn, Elizabeth J., additional, Pullan, Steve, additional, Taylor, Irene, additional, Tipton, Tom, additional, Thomas, Stephen, additional, Tree, Julia A., additional, Turner, Carrie, additional, Wand, Nadina, additional, Wiblin, Nathan R., additional, Charlton, Sue, additional, Hallis, Bassam, additional, Pearson, Geoffrey, additional, Rayner, Emma L., additional, Nicholson, Andrew G., additional, Funnell, Simon G., additional, Dennis, Mike J., additional, Gleeson, Fergus V., additional, Sharpe, Sally, additional, and Carroll, Miles W., additional
- Published
- 2020
- Full Text
- View/download PDF
26. Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge
- Author
-
Ryan, Kathryn A., primary, Bewley, Kevin R., additional, Fotheringham, Susan A., additional, Brown, Phillip, additional, Hall, Yper, additional, Marriott, Anthony C., additional, Tree, Julia A., additional, Allen, Lauren, additional, Aram, Marilyn J., additional, Brunt, Emily, additional, Buttigieg, Karen R., additional, Cavell, Breeze E., additional, Carter, Daniel P., additional, Cobb, Rebecca, additional, Coombes, Naomi S., additional, Godwin, Kerry J., additional, Gooch, Karen E., additional, Gouriet, Jade, additional, Halkerston, Rachel, additional, Harris, Debbie J., additional, Humphries, Holly E., additional, Hunter, Laura, additional, Ho, Catherine M. K., additional, Kennard, Chelsea L., additional, Leung, Stephanie, additional, Ngabo, Didier, additional, Osman, Karen L., additional, Paterson, Jemma, additional, Penn, Elizabeth J., additional, Pullan, Steven T., additional, Rayner, Emma, additional, Slack, Gillian S., additional, Steeds, Kimberley, additional, Taylor, Irene, additional, Tipton, Tom, additional, Thomas, Stephen, additional, Wand, Nadina I., additional, Watson, Robert J., additional, Wiblin, Nathan R., additional, Charlton, Sue, additional, Hallis, Bassam, additional, Hiscox, Julian A., additional, Funnell, Simon, additional, Dennis, Mike J., additional, Whittaker, Catherine J., additional, Catton, Michael G., additional, Druce, Julian, additional, Salguero, Francisco J., additional, and Carroll, Miles W., additional
- Published
- 2020
- Full Text
- View/download PDF
27. Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea
- Author
-
Sissoko, Daouda, Laouenan, Cedric, Folkesson, Elin, M'Lebing, Abdoul-Bing, Beavogui, Abdoul-Habib, Baize, Sylvain, Camara, Alseny-Modet, Maes, Piet, Shepherd, Susan, Danel, Christine, Carazo, Sara, Conde, Mamoudou N., Gala, Jean-Luc, Colin, Géraldine, Savini, Hélène, Bore, Joseph Akoi, Le Marcis, Frederic, Koundouno, Fara Raymond, Petitjean, Frédéric, Lamah, Marie-Claire, Diederich, Sandra, Tounkara, Alexis, Poelart, Geertrui, Berbain, Emmanuel, Dindart, Jean-Michel, Duraffour, Sophie, Lefevre, Annabelle, Leno, Tamba, Peyrouset, Olivier, Irenge, Léonid, Bangoura, N'Famara, Palich, Romain, Hinzmann, Julia, Kraus, Annette, Barry, Thierno Sadou, Berette, Sakoba, Bongono, André, Camara, Mohamed Seto, Chanfreau Munoz, Valérie, Doumbouya, Lanciné, Souley Harouna, Kighoma, Patient Mumbere, Koundouno, Fara Roger, Réné Lolamou, Loua, Cécé Moriba, Massala, Vincent, Moumouni, Kinda, Provost, Célia, Samake, Nenefing, Sekou, Conde, Soumah, Abdoulaye, Arnould, Isabelle, Komano, Michel Saa, Gustin, Lina, Berutto, Carlotta, Camara, Diarra, Camara, Fodé Saydou, Colpaert, Joliene, Delamou, Léontine, Jansson, Lena, Kourouma, Etienne, Loua, Maurice, Malme, Kristian, Manfrin, Emma, Maomou, André, Milinouno, Adele, Ombelet, Sien, Sidiboun, Aboubacar Youla, Verreckt, Isabelle, Yombouno, Pauline, Bocquin, Anne, Carbonnelle, Caroline, Carmoi, Thierry, Frange, Pierre, Mely, Stéphane, Nguyen, Vinh-Kim, Pannetier, Delphine, Taburet, Anne-Marie, Treluyer, Jean-Marc, Kolie, Jacques, Moh, Raoul, Gonzalez, Minerva Cervantes, Kuisma, Eeva, Liedigk, Britta, Ngabo, Didier, Rudolf, Martin, Thom, Ruth, Kerber, Romy, Gabriel, Martin, Di Caro, Antonino, Wölfel, Roman, Badir, Jamal, Bentahir, Mostafa, Deccache, Yann, Dumont, Catherine, Durant, Jean-François, El Bakkouri, Karim, Gasasira Uwamahoro, Marie, Smits, Benjamin, Toufik, Nora, Van Cauwenberghe, Stéphane, Ezzedine, Khaled, Dortenzio, Eric, Pizarro, Louis, Etienne, Aurélie, Guedj, Jérémie, Fizet, Alexandra, Barte de Sainte Fare, Eric, Murgue, Bernadette, Tran-Minh, Tuan, Rapp, Christophe, Piguet, Pascal, Poncin, Marc, Draguez, Bertrand, Allaford Duverger, Thierry, Barbe, Solenne, Baret, Guillaume, Defourny, Isabelle, Carroll, Miles, Raoul, Hervé, Augier, Augustin, Eholie, Serge P., Yazdanpanah, Yazdan, Levy-Marchal, Claire, Antierrens, Annick, Van Herp, Michel, Günther, Stephan, de Lamballerie, Xavier, Keïta, Sakoba, Mentre, France, Anglaret, Xavier, and Malvy, Denis
- Subjects
Ebola hemorrhagic fever -- Drug therapy ,Antiviral agents -- Patient outcomes ,Biological sciences - Abstract
Background Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak, the World Health Organization released a short list of drugs suitable for EVD research. Favipiravir, an antiviral developed for the treatment of severe influenza, was one of these. In late 2014, the conditions for starting a randomized Ebola trial were not fulfilled for two reasons. One was the perception that, given the high number of patients presenting simultaneously and the very high mortality rate of the disease, it was ethically unacceptable to allocate patients from within the same family or village to receive or not receive an experimental drug, using a randomization process impossible to understand by very sick patients. The other was that, in the context of rumors and distrust of Ebola treatment centers, using a randomized design at the outset might lead even more patients to refuse to seek care. Therefore, we chose to conduct a multicenter non-randomized trial, in which all patients would receive favipiravir along with standardized care. The objectives of the trial were to test the feasibility and acceptability of an emergency trial in the context of a large Ebola outbreak, and to collect data on the safety and effectiveness of favipiravir in reducing mortality and viral load in patients with EVD. The trial was not aimed at directly informing future guidelines on Ebola treatment but at quickly gathering standardized preliminary data to optimize the design of future studies. Methods and Findings Inclusion criteria were positive Ebola virus reverse transcription PCR (RT-PCR) test, age [greater than or equal to] 1 y, weight [greater than or equal to] 10 kg, ability to take oral drugs, and informed consent. All participants received oral favipiravir (day 0: 6,000 mg; day 1 to day 9: 2,400 mg/d). Semi-quantitative Ebola virus RT-PCR (results expressed in 'cycle threshold' [Ct]) and biochemistry tests were performed at day 0, day 2, day 4, end of symptoms, day 14, and day 30. Frozen samples were shipped to a reference biosafety level 4 laboratory for RNA viral load measurement using a quantitative reference technique (genome copies/milliliter). Outcomes were mortality, viral load evolution, and adverse events. The analysis was stratified by age and Ct value. A 'target value' of mortality was defined a priori for each stratum, to guide the interpretation of interim and final analysis. Between 17 December 2014 and 8 April 2015, 126 patients were included, of whom 111 were analyzed (adults and adolescents, [greater than or equal to]13 y, n = 99; young children, [less than or equal to]6 y, n = 12). Here we present the results obtained in the 99 adults and adolescents. Of these, 55 had a baseline Ct value [greater than or equal to] 20 (Group A Ct [greater than or equal to] 20), and 44 had a baseline Ct value < 20 (Group A Ct < 20). Ct values and RNA viral loads were well correlated, with Ct = 20 corresponding to RNA viral load = 7.7 log.sub.10 genome copies/ml. Mortality was 20% (95% CI 11.6%-32.4%) in Group A Ct [greater than or equal to] 20 and 91% (95% CI 78.8%-91.1%) in Group A Ct < 20. Both mortality 95% CIs included the predefined target value (30% and 85%, respectively). Baseline serum creatinine was [greater than or equal to]110 [mu]mol/l in 48% of patients in Group A Ct [greater than or equal to] 20 ([greater than or equal to]300 [mu]mol/l in 14%) and in 90% of patients in Group A Ct < 20 ([greater than or equal to]300 [mu]mol/l in 44%). In Group A Ct [greater than or equal to] 20, 17% of patients with baseline creatinine [greater than or equal to]110 [mu]mol/l died, versus 97% in Group A Ct < 20. In patients who survived, the mean decrease in viral load was 0.33 log.sub.10 copies/ml per day of follow-up. RNA viral load values and mortality were not significantly different between adults starting favipiravir within Conclusions In the context of an outbreak at its peak, with crowded care centers, randomizing patients to receive either standard care or standard care plus an experimental drug was not felt to be appropriate. We did a non-randomized trial. This trial reaches nuanced conclusions. On the one hand, we do not conclude on the efficacy of the drug, and our conclusions on tolerance, although encouraging, are not as firm as they could have been if we had used randomization. On the other hand, we learned about how to quickly set up and run an Ebola trial, in close relationship with the community and non-governmental organizations; we integrated research into care so that it improved care; and we generated knowledge on EVD that is useful to further research. Our data illustrate the frequency of renal dysfunction and the powerful prognostic value of low Ct values. They suggest that drug trials in EVD should systematically stratify analyses by baseline Ct value, as a surrogate of viral load. They also suggest that favipiravir monotherapy merits further study in patients with medium to high viremia, but not in those with very high viremia. Trial registration ClinicalTrials.gov NCT02329054, Author(s): Daouda Sissoko 1,2, Cedric Laouenan 3,4, Elin Folkesson 5, Abdoul-Bing M'Lebing 6, Abdoul-Habib Beavogui 7, Sylvain Baize 8,9, Alseny-Modet Camara 5, Piet Maes 10,11, Susan Shepherd 6, Christine Danel [...]
- Published
- 2016
- Full Text
- View/download PDF
28. Cabinet Decontamination Using Formaldehyde
- Author
-
Ngabo, Didier, primary, Pottage, Thomas, additional, Bennett, Allan, additional, and Parks, Simon, additional
- Published
- 2017
- Full Text
- View/download PDF
29. Biofilm formation in an experimental water distribution system: the contamination of non-touch sensor taps and the implication for healthcare
- Author
-
Moore, Ginny, primary, Stevenson, David, additional, Thompson, Katy-Anne, additional, Parks, Simon, additional, Ngabo, Didier, additional, Bennett, Allan M., additional, and Walker, Jimmy T., additional
- Published
- 2015
- Full Text
- View/download PDF
30. Correction: Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.
- Author
-
Sissoko D, Laouenan C, Folkesson E, M'Lebing AB, Beavogui AH, Baize S, Camara AM, Maes P, Shepherd S, Danel C, Carazo S, Conde MN, Gala JL, Colin G, Savini H, Bore JA, Le Marcis F, Koundouno FR, Petitjean F, Lamah MC, Diederich S, Tounkara A, Poelart G, Berbain E, Dindart JM, Duraffour S, Lefevre A, Leno T, Peyrouset O, Irenge L, Bangoura N, Palich R, Hinzmann J, Kraus A, Barry TS, Berette S, Bongono A, Camara MS, Munoz VC, Doumbouya L, Harouna S, Kighoma PM, Koundouno FR, Lolamou R, Loua CM, Massala V, Moumouni K, Provost C, Samake N, Sekou C, Soumah A, Arnould I, Komano MS, Gustin L, Berutto C, Camara D, Camara FS, Colpaert J, Delamou L, Jansson L, Kourouma E, Loua M, Malme K, Manfrin E, Maomou A, Milinouno A, Ombelet S, Sidiboun AY, Verreckt I, Yombouno P, Bocquin A, Carbonnelle C, Carmoi T, Frange P, Mely S, Nguyen VK, Pannetier D, Taburet AM, Treluyer JM, Kolie J, Moh R, Gonzalez MC, Kuisma E, Liedigk B, Ngabo D, Rudolf M, Thom R, Kerber R, Gabriel M, Di Caro A, Wölfel R, Badir J, Bentahir M, Deccache Y, Dumont C, Durant JF, El Bakkouri K, Uwamahoro MG, Smits B, Toufik N, Van Cauwenberghe S, Ezzedine K, D'Ortenzio E, Pizarro L, Etienne A, Guedj J, Fizet A, de Sainte Fare EB, Murgue B, Tran-Minh T, Rapp C, Piguet P, Poncin M, Draguez B, Duverger TA, Barbe S, Baret G, Defourny I, Carroll M, Raoul H, Augier A, Eholie SP, Yazdanpanah Y, Levy-Marchal C, Antierrens A, Van Herp M, Günther S, de Lamballerie X, Keïta S, Mentre F, Anglaret X, and Malvy D
- Abstract
[This corrects the article DOI: 10.1371/journal.pmed.1001967.].
- Published
- 2016
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.