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1,069 results on '"Nguyen, Van-Huy"'

41. A language score based output selection method for multilingual speech recognition

Author

Nguyen, Van Huy, Dinh, Thi Quynh Khanh, Nguyen, Truong Thinh, and Mac, Dang Khoa

Subjects
Computer Science - Computation and Language
Abstract

The quality of a multilingual speech recognition system can be improved by adaptation methods if the input language is specified. For systems that can accept multilingual inputs, the popular approach is to apply a language identifier to the input then switch or configure decoders in the next step, or use one more subsequence model to select the output from a set of candidates. Motivated by the goal of reducing the latency for real-time applications, in this paper, a language model rescoring method is firstly applied to produce all possible candidates for target languages, then a simple score is proposed to automatically select the output without any identifier model or language specification of the input language. The main point is that this score can be simply and automatically estimated on-the-fly so that the whole decoding pipeline is more simple and compact. Experimental results showed that this method can achieve the same quality as when the input language is specified. In addition, we present to design an English and Vietnamese End-to-End model to deal with not only the problem of cross-lingual speakers but also as a solution to improve the accuracy of borrowed words of English in Vietnamese.

Published
2020

42. Mutation spectrum of retinoblastoma patients in Vietnam

Author

Dao Nguyen Ha Linh, Nguyen Van Huy, Phuoc‐Dung Nguyen, Phuong Le Thi, Hoang Anh Tuan, Trong Van Nguyen, Thu Ha Tran, Hai Anh Tran, Thanh Dat Ta, Tuan L. A. Pham, The‐Hung Bui, Thinh Huy Tran, Thanh Van Ta, and Van‐Khanh Tran

Subjects
MLPA, mutation, RB1 gene, retinoblastoma, sequencing, Genetics, QH426-470
Abstract

Abstract Background Retinoblastoma (RB), an intraocular malignancy commonly diagnosed in children, is mostly caused by inactivating mutations of both alleles of the RB1 gene. Early genetic screening for RB1 gene mutations would greatly improve treatment outcomes and patient management. Methods In this study, both somatic and germline mutations were detected in blood and tumour samples of 42 RB patients using direct sequencing and multiplex ligation‐dependent probe amplification. Results In total, 34 different mutations were found in 36 patients, including 1 SNP, 4 large deletions, 5 splicing sites, 1 missense, 7 frameshifts and 17 nonsense mutations. There were five novel mutations and one unreported which have not been found in large databases such as Leiden Open Variation Database (LOVD) and ClinVar. Conclusion A higher rate of RB patients carrying heterozygous germline mutation and highly prevalent with pathogenic truncated mutation, hence, early detection of RB is essential for vision salvation and genetic counselling.

Published
2023
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