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Objectives: To evaluate the efficacy of autologous non-cultured melanocyte-keratinocyte transplantation for the management of stable vitiligo. Objects and methods: Clinical trial with pre - -post comparison on 30 stable vitiligo patients by autologous non-cultured melanocyte-keratinocyte transplantation technique. Evaluations of repigmented efficacy and complications were carried - out every 4 weeks in 6 months. Results: 6 months after treatment with autologous non-cultured melanocyte-keratinocyte transplantation technique, an excellent response of repigmentation was seen in 30% of the cases and 36,7% of the cases reached good response Conclusions: Autologous non-cultured melanocyte-keratinocyte transplantation can be an effective method for the treatment of stable vitiligo.