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Abstract Background The Arg64 allele of the rs4994 (Trp64Arg) variant in the β3-adrenergic receptor (ADRB3) gene is involved in the control of energy balance by altering lipolysis and thermogenesis in adipocytes, ultimately contributing to the development of obesity. The objective of our study was to investigate the association between the rs4994 variant of the ADRB3 gene and obesity in Hanoi preschool-age children, adjusting for their eating behaviors. Methods A cross-sectional study was performed involving 708 children with normal weight and 304 children with obesity aged 3–5 years from 36 kindergartens in Hanoi, Vietnam. Cheek mucosa cell samples were used for DNA extraction, and genotyping at the ADRB3-rs4994 locus was performed using the polymerase chain reaction–restriction fragment length polymorphism method (PCR–RFLP). Eating behaviors were assessed using the Children’s Eating Behaviour Questionnaire (CEBQ). Binary logistic regression analysis was employed to examine the association between the rs4994 variant and obesity, adjusting for confounding factors such as age, sex, residence, birth weight, and eating behaviors. Results The frequency of the C allele in the group with obesity was 16.4%, which was higher than in the control group (11.7%, P = 0.003). Children with the CC genotype exhibited significantly greater weight and weight-for-age Z-score compared to those with the TT and TC genotypes (P = 0.004 and 0.03, respectively). Following univariate and multivariate analyses adjusted for age, sex, residence, birth weight, and eating behaviors, a significant association between the rs4994 variant and obesity was observed (P

Abstract Background To formulate effective strategies for antimicrobial stewardship (AMS) in primary care, it is crucial to gain a thorough understanding of factors influencing prescribers' behavior within the context. This qualitative study utilizes the Theoretical Domains Framework (TDF) to uncover these influential factors. Methods We conducted a qualitative study using in-depth interviews and focus group discussions with primary care workers in two provinces in rural Vietnam. Data analysis employed a combined inductive and deductive approach, with the deductive aspect grounded in the TDF. Results Thirty-eight doctors, doctor associates, and pharmacists participated in twenty-two interviews and two focus group discussions. We identified sixteen themes, directly mapping onto seven TDF domains: knowledge, skills, behavioral regulation, environmental context and resources, social influences, social/professional role and identity, and optimism. Factors driving unnecessary prescription of antibiotics include low awareness of antimicrobial resistance (AMR), diagnostic uncertainty, prescription-based reimbursement policy, inadequate medication supplies, insufficient financing, patients’ perception of health insurance medication as an entitlement, and maintaining doctor-patient relationships. Potential factors facilitating AMS activities include time availability for in-person patient consultation, experience in health communication, and willingness to take action against AMR. Conclusion Utilizing the TDF to systematically analyze and present behavioral determinants offers a structured foundation for designing impactful AMS interventions in primary care. The findings underscore the importance of not only enhancing knowledge and skills but also implementing environmental restructuring, regulation, and enablement measures to effectively tackle unnecessary antibiotic prescribing in this context.

Turmeric, extensively cultivated across Southeast Asia, especially in Vietnam, harbors active polyphenols, primarily curcumin (2–5%), renowned for its diverse health benefits. Pharmacopoeias recognize turmeric, yet it lacks standardized quality assessments and encounters challenges in extraction and identification due to natural variations and adulteration. This analytical method is vital for verifying the authenticity, purity, and quality of turmeric products in both the pharmaceutical and nutraceutical industries. This study successfully developed an efficient extraction process for curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) from Curcuma longa L. rhizomes. The herbal powder was extracted with methanol (1:30, w/v) by the ultrasound-assisted method for 10 minutes, and this process was repeated three times. A high-performance liquid chromatography-diode array detector (HPLC-DAD) method was validated for the simultaneous quantification of three analytes, following the AOAC guideline and achieving a correlation coefficient (R2) value greater than 0.9950. Utilizing the HPLC-DAD method, the study developed a chemical fingerprint analysis for three analytes to identify the characteristic chemical components distinguishing turmeric from each region. Nineteen samples collected from various provinces across Vietnam were subjected to analysis. In all analyzed samples, the concentrations of CUR, DMC, and BDMC ranged from 0.77–10.30%, 0.33–6.92%, and 0.03–3.23%, respectively. CUR was determined to be the dominant compound in most samples, while BDMC consistently exhibited the lowest levels of content. Utilizing the findings derived from the analysis of RRT and RPA metrics, the research assessed variances across sample batches. It is suggested that this newly established approach can be applied to construct and develop raw material areas to serve the needs of each field.

This investigation examined English as a foreign language (EFL) teachers' perceptions of their self-efficacy in using instructional strategies in the context of the Mekong Delta of Vietnam. The research was designed as a descriptive research collecting quantitative and qualitative data from a questionnaire and semi-structured interviews. Forty-six Vietnamese EFL teachers were invited to partake in the study. The results indicated that participants were in general confident in using instructional strategies in their English classes. Specifically, the participants were highly confident in their abilities to use multimedia (M=4.41), assessment techniques (M=4.35), and classroom English (M=4.35). The study also indicated that participants were not confident in evaluating the level of task difficulty (M=3.37), dealing with unmotivated students (M=3.57), and meeting students' particular needs for support (M=3.62). Pedagogical implications and recommendations were addressed to help manifold stakeholders at the end of this paper.

Numeracy is one of the essential competencies that the objectives of teaching math to primary students should be towards. However, many research findings show that the problem of "innumeracy" frequently exists at primary schools. That means children still do not feel at home in the world of numbers and operations. Therefore, the paper aims to apply the realistic mathematics education (RME) approach to tackling the problem of innumeracy, in the case of teaching the multiplication of two natural numbers to primary students. We conducted a pedagogical experiment with 46 grade 2 students who have not studied the multiplication yet. The pedagogical experiment lasted in six lessons, included seven activities and nine worksheets which are designed according to fundamental principles of RME by researchers. This is mainly a qualitative study. Based on data obtained from classroom observations and students' response on worksheets, under the perspective of RME, the article pointed out how mathematization processes took place throughout students' activities, their attitudes towards math learning, and their learning outcomes. The study results found that students were more interested in math learning and understood the concepts of multiplication of two natural numbers.

Electric arc furnace dust (EAFD), categorized as hazardous waste, contains notable concentrations of zinc. This research involved inducing the in situ deposition of zinc ions from EAFD on activated carbon (AC) surfaces, followed by the formation of ZIF-8 on the AC surface through the addition of 2-methylimidazole. The resulting ZIF-8/AC composite was utilized for adsorbing reactive and dispersed dyes. The characterization of the as-prepared ZIF-8/AC was accomplished by XRD, FT-IR, SEM, EDX, BET, XPS, and TGA. The as-prepared composite was tested for adsorption of reactive blue 19 (RB19) and chromatint yellow 3247 (CY3247) dispersion dyes. The ZIF-8/AC6 adsorbent produced the best removal efficiency for CY3247 (96.47%) and RB19 (98.63%). The highest removal efficiencies were 99.51 and 96.52% for RB19 and CY3247, respectively (concentration of 25 mg/mL). The Langmuir model yielded the maximum adsorption capacity (84.03 mg/g for RB19 and 72.46 mg/g for CY3247) coupled with strong correlation coefficient values. The Langmuir isotherm model was identified as the most fitting representation of equilibrium based on experimental data. The pseudo-second order rate model offers the most accurate depiction of the adsorption kinetics, and the Langmuir model proves suitable for describing the adsorption of RB19 and CY3247 on ZIF-8/AC.

AbstractUsing the GJR-GARCH method, this study examines the safe-haven role of gold, US dollar, and Bitcoin over a period including the global financial crisis, the COVID-19 pandemic and the Russia-Ukraine conflict from 3 April 2006 to 19 May 2023. The study supports the hypothesis that the safe-haven role of assets changes over periods of crisis. Specifically, gold loses its role as a safe-haven asset during the COVID-19 pandemic, but this role has been restored in the Dutch, US and German markets during the Russia-Ukraine conflict. Similarly, Bitcoin is not a safe-haven asset during the COVID-19 pandemic but is a strong safe-haven asset for the stock markets of some European countries, and a weak safe-haven asset for China when the Russia-Ukraine conflict occurred. Only the USD acts as a stable safe-haven asset through periods of crisis. However, this role is weakened in Russia. These results partly help investors and portfolio managers choose a safe haven for their assets, especially during volatile market periods.

Electronic word-of-mouth (e-WOM) has gained popularity due to the fact that people can communicate and discuss brands through emotive expressions, remarks, and reviews regardless of their distance. The purpose and objectives of this study are to determine how e-WOM factors, such as brand image, brand awareness, and brand loyalty based on trust, influence brand equity. The study’s methodology included both qualitative and quantitative research to examine consumers’ perspectives and generalize the findings, respectively. For qualitative research on e-WOM variables, both in-depth interviews and focus groups are utilized. The next stage is to collect online responses from 410 participants and evaluate their relationships using a structural equation modeling (SEM) model. The findings suggest that content quality, the number of reviews, norm conflict, and sponsored recommendations are the characteristics that generate e-WOM and enhance the ability to establish trust in these reviews. This enhances the brand equity of digital businesses. This demonstrates the factors that managers should emphasize in order to enhance the positive effects of e-WOM and thereby increase brand equity.

Forest carbon markets have demonstrated numerous benefits across economic, social, and environmental dimensions, while also advancing sustainable development goals. This study examines the primary policy mechanisms and conditions related to the development of high-integrity forest carbon markets in Dak Lak province, Vietnam. Utilizing a combination of SWOT analysis and the DPSIR framework, the study provides a comprehensive evaluation of the opportunities, challenges, driving forces, pressures, potential impacts, and responses associated with developing these markets. The Gold Standard method was also employed to estimate the potential contribution to carbon emission reductions through the new forest planting programs in the province. Data analysis from 202 households and in-depth interviews with fifteen experts revealed that local residents have limited information about the forest carbon market. While forest management officials at various levels are aware of the market, there is a lack of specific guidance, limited participation in training sessions and workshops, and insufficient instructional materials. Dak Lak holds significant potential for carbon emission reductions, with an estimated average forest carbon storage capacity of 7.5 tCO2/ha/year for an afforestation/reforestation (A/R) carbon project. This initiative is projected to contribute approximately $753,972 annually to the province's GRDP and generate 280 jobs for local communities. However, the technical and financial resources are challenging in the province. The study identifies critical issues and proposes appropriate solutions to support Dak Lak in developing high-integrity forest carbon markets in alignment with the national roadmap, ultimately contributing to the achievement of sustainable development goals.

The growing interplay between environmental innovation, digitalization, and total factor productivity (TFP) in agriculture highlights an urgent need to understand their complex relationships. This study utilizes the R2 decomposed linkage method to examine contemporaneous and lagged linkages among environmental innovation, digitalization, and TFP in Vietnam’s agricultural sector from 1994 to 2022. Our findings indicate that digitalization had a weak control on environmental innovation from 2010 to 2015 and in 2022, with a reversal observed during the 2008-2010 period and, more notably, from 2018 onward. Digitalization also dominated agriculture before 2008 and from 2019 to 2020, with significant effects from 2010 to 2016. Environmental innovation primarily influenced TFP from 2014 to the end of the period, with both contemporaneous and lagged effects. Since 2017, digitalization has increasingly driven environmental innovation, exemplified by advancements in precision agriculture and environmental monitoring technologies. These innovations have notably enhanced agricultural TFP, improving efficiency and productivity through digital tools and data analytics. Overall, these results highlight the critical role of digital technologies in advancing agricultural productivity and environmental sustainability, suggesting that continued investment in digitalization is essential for fostering growth and innovation in the sector.

Coumarin derivatives possess diverse biological activities, encompassing antibacterial, antifungal, anticancer, antidiabetic, anti-inflammatory, and antioxidant effects. This study concentrates on the synthesis of two new coumarins: the first derived from rhizomes of Luvunga scandens and the second from 7-(diethylamino)-4-methyl-2H-chromen-2-one via bromination facilitated by NBS (N-bromosuccinimide) reagent. Their antibacterial and anticancer properties were evaluated in vitro, alongside in silico docking targeting the chromen-2-one group. Bromination of compound 1 yielded novel compound 2, while compound 4 was efficiently synthesized from 7-(diethylamino)-4-methyl-2H-chromen-2-one (3) using NBS. Testing on lung, breast, and liver cancer cell lines indicated that compound 2 effectively inhibited Staphylococcus aureus and Bacillus cereus at concentrations of 13.20 and 6.6 µM, respectively. It also demonstrated significant inhibition against MCF-7 breast cancer cells with a half-maximal inhibitory concentration (IC50) value of 50.37 ± 3.70 µM. Molecular docking revealed compound 2’s interaction with 2VF5 enzyme, elucidating its bacterial inhibition mechanism, with Gibbs energy and inhibition constant values of -7.42 kcal mol-1 and 3.62 µM, respectively. Additionally, compound 2 exhibited anticancer activity via alignment with topoisomerase 1 (3TOP): 1T8I, supported by molecular dynamics simulations illustrating strong ligand interactions. Analysis of pharmacophore kinetics highlighted the complex’s hydrophilic nature, indicating its potential therapeutic efficacy.

The purpose of this study is to examine the influence of green human resource management (GHRM) on employees’ green behavior (EGB) in hotels in Vietnam. To fulfill social responsibility towards the environment, many organizations have been paying more attention to GHRM, thereby forming EGB. Especially in today's situation where global warming is increasing, “green” practices should be adopted by organizations, starting from the core of organizations—their human resources. The success of an organization's initiative to sustain environmental sustainability largely depends on promoting green behavior among employees. The study used a mixed method, incorporating qualitative feedback from previous studies, experts, and quantitative data from 556 employees working in hotels in Vietnam. Filtering was performed on the data to remove outliers and demonstrate statistical, confirmatory factor analysis, and structural equation modeling. The results show that GHRM activities such as green recruitment, green training and development, green job performance management and appraisal, and providing green compensation strongly influence EGB. Additionally, the study also indicates that EGB varies based on work experience and the type of hotel where they are employed. Hotels operating in the tourism industry have been paying more attention to GHRM, thereby forming EGB. In the tourism industry, hotels must ensure environmental protection goals more than ever. Developers and managers can utilize more development tactics to enhance GHRM and EGB.

This study aimed to explore the reading motivation of students at Skyline School in Da Nang city and its correlation with their overall reading achievement. Data was collected through surveys on 50 students, descriptive analysis, and interviews conducted with students randomly chosen. The researchers sought to understand the reasons behind the students' moderate reading motivation levels, which is proved to relate to complex texts, unfamiliar vocabularies, and intricate sentence structures. Additionally, linguistic barriers were identified as contributing factors. Shifting interests, competing priorities, such as extracurricular activities and social influences, such as peer influence and societal attitudes towards reading, were also found to influence students' reading motivation. Furthermore, the researcher identified limited metacognitive awareness as a hindrance to students' effective engagement with English texts.

Voice Assistants have gained more attention in both real-life and academic fields thanks to their roles in the advanced world. This study aims to investigate the Behavioral Intention of Voice Assistants’ users by exploring the mediating role of Subjective Well-being and the moderating role of Innovativeness based on the Utilitarian and Gratification Theory framework. A quantitative study with structural equation modeling was carried out using SPSS and PLS-SEM software to analyze a sample of 230 Voice Assistant users. The findings illustrate that the Subjective Well-being of Voice Assistants’ users is influenced by Utilitarian benefits, Symbolic benefits and Social benefits. Behavioral intention is directly influenced by Utilitarian benefits, Hedonic benefits and Social benefits. The research establishes the moderating role of Innovativeness in the relationship of Subjective Well-being and Behavioral Intention. This study provides deeper insight into the motivations of Voice Assistants’ users from social and psychological viewpoints.

Abstract The first nationwide outbreak of COVID-19 in Vietnam started in late April 2021 and was caused almost exclusively by a single Delta lineage, AY.57. In early 2022, multiple Omicron variants co-circulated with Delta variants and quickly became dominant. The co-circulation of Delta and Omicron happened leading to possibility of co-infection and recombination events which can be revealed by viral genomic data. From January to October 2022, a total of 1028 viral RNA samples out of 4852 positive samples (Ct

This paper discusses the difficulties and solutions perceived by English-majored students when it comes to developing their speaking skills. To uncover and analyze these problems, one hundred fifty-seven students and five English lecturers at Vinh University participated in this study by completing the questionnaire and doing follow-up interviews to specify the findings. The findings indicate that students encountered difficulties in speaking proficiency attributed to two main factors: internal and external. Some suggestions given by both students and lecturers are proposed to assist students in improving their English-speaking skills.

An assessment is a way of gathering and discussing data from various sources to gain an understanding of what a student knows, understands, and is able to do with their knowledge resulting from their education to improve their future learning. The purposes of this study were to see the motivation of students to learn the English project suggested in the ESP Course, Business Meetings Project, and also measured the student's success in language skills, especially oral communication skills.The study was conducted using an action research method where a questionnaire, students' achievements, and classroom activities were taken as the data. The questionnaire was scored using the Likert scale rating. Students will respond to this scale by rating the motivation factor on a scale. The researchers employed a pre- and post-test to determine how much the students' abilities had improved. The pre-test and post-test mean scores were compared and computed by the researcher using the T-test technique. The participants were 26 students from the Accounting Department of the State Polytechnic Of Malang. The outcome of this study was the successful implementation of the model. The T-test for the first project showed 62,30, the second project had 74,69, and the third project had 79,30.

Objective: Obesity is a complex disease that involves interactions between environmental and genetic factors in its pathogenesis. The aims of this present study were to analyse the overall effects of some nutritional, physical and genetic factors with childhood obesity, and to build predictive models of childhood obesity. Material and Methods: A case-control study was conducted on 559 Hanoi primary school children (278 obese cases and 281 normal controls). Genetic analysis was performed to evaluate genotype on the rs6265 gene BDNF, rs6548238 gene TMEM18, rs6499640 gene FTO, and rs17782313 gene MC4R. Univariate and multivariate regression analysis were conducted to compare the two groups of children, so as to draw conclusions regarding influencing factors and to establish predictive models of obesity for Hanoi primary school children. Results: Factors increasing the risk of obesity found included: urban living areas (odds ratio (OR)=1.5), caesarean section (OR=2.1), high birth weight (OR=1.9-3.1), parental overweight and obesity (OR=2.1-5.1), short night sleeping times (OR=2.6), characteristics of child feeding; including early weaning (OR=2.1), gluttony (OR=19.1), no snacking (OR=2.4), controlled eating (OR=2.4) fat food hobbies (OR=2.7), and CC rs6548238-TMEM18 genotype (OR=1.8). A predictive model of childhood obesity for Hanoi primary school children was built, based on the BMI of parents, gluttonous characteristics, unrestricted eating with ROC=0.871. Conclusion: Childhood obesity develops as a result of interaction between eating habits, lifestyle characteristics of the child and genetic characteristics inherited from over nutritious parents. Encouraging parents to manage both their own weight and their children’s eating habits such as allowing children to consume food without undue restriction and reducing gluttony can serve as effective interventions to diminish the prevalence of childhood obesity within the community.

Abstract Introduction Staphylococcus aureus (S. aureus) is an important pathogen in both community-acquired and hospital-acquired pneumonia. S. aureus pneumonia has a high mortality rate and serious complications. Resistance to multiple antibiotics is a major challenge in the treatment of S. aureus pneumonia. Understanding the antibiotic resistance profile of S. aureus and the risk factors for mortality can help optimize antibiotic regimens and improve patient outcomes in S. aureus pneumonia. Methods A prospective cohort study of 118 patients diagnosed with S. aureus pneumonia between May 2021 and June 2023 was conducted, with a 30-day follow-up period. Demographic information, comorbidities, Charlson Comorbidity Index, clinical characteristics, outcomes, and complications were collected for each enrolled case. The data were processed and analyzed using R version 3.6.2. Results S. aureus pneumonia has a 30-day mortality rate of approximately 50%, with complication rates of 22% for acute respiratory distress syndrome (ARDS), 26.3% for septic shock, and 14.4% for acute kidney injury (AKI). Among patients with methicillin-resistant S. aureus (MRSA) pneumonia treated with vancomycin (n = 40), those with a vancomycin minimum inhibitory concentration (MIC) ≤ 1 had significantly higher cumulative survival at day 30 compared to those with MIC ≥ 2 (log-rank test p = 0.04). The prevalence of MRSA among S. aureus isolates was 84.7%. Hemoptysis, methicillin resistance, acidosis (pH