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Your search keyword '"Nho, Youn Hwa"' showing total 15 results
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15 results on '"Nho, Youn Hwa"'

3. Efficacy and safety of topical Streptococcus postbiotic emollient in adolescents and adults with mild‐to‐moderate atopic dermatitis: A randomized, double‐blind, vehicle‐controlled trial

Author

Kim, Min Seo, primary, Kim, Hyeon Jin, additional, Kang, So Min, additional, Heo, Young Mok, additional, Kang, Jiseung, additional, Ryu, Tae Kyeong, additional, Kim, Hyun Jeong, additional, Choi, Young‐Bong, additional, Kim, Sol, additional, Nho, Youn Hwa, additional, Kang, Seunghyun, additional, Smith, Lee, additional, Koyanagi, Ai, additional, Papadopoulos, Nikolaos G., additional, Jo, Hyungwoo, additional, Lee, Dong‐Geol, additional, Shin, Jung U, additional, and Yon, Dong Keon, additional

Published
2024
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4. A Glance into the Destiny of Transcriptomic Activity, Embodied by the HOX Genes, in Neonatal and Aging Dermal Cells.

Author

Ko, Doyeong, Mun, Seyoung, Kim, Minji, Nho, Youn‐Hwa, Lee, Dong‐Geol, Kang, Seunghyun, Han, Kyudong, and Kim, Misun

Subjects
HOMEOBOX genes, CELLULAR aging, SKIN aging, GENE families, GENE expression, EMBRYOLOGY
Abstract

Skin is an organ having a crucial role in the protection of muscle, bone, and internal organs and undergoing continuous self‐renewal and aged. The growing interest in the prevention of skin aging and rejuvenation has sparked a surge of industrial and research studies focusing on the biological and transcriptional changes that occur during skin development and aging. In this study, the aim is to identify transcriptional differences between two main types of human skin cells: the human dermal fibroblasts (HDFs) and the human epidermis keratinocytes (HEKs) isolated from 30 neonatal and 30 adults (old) skin. Through differentially expressed gene (DEG) profiling using DEseq2, 604 up‐, and 769 down‐regulated genes are identified in the old group. A functional analysis using Metascape Gene Ontology and Reactome pathways revealed systematic transcriptomic shifts in key skin formation and maintenance markers, alongside a distinct difference in HOX gene families crucial for embryonic development and diverse biological processes. Among the 39 human HOX gene family, ten posterior HOX genes (HOXA10, 11, 13, HOXB13, HOXC11, and HOXD9‐13) are significantly downregulated, and anterior 25 genes (HOXA2‐7, HOXB1‐9, HOXC4‐6 and 8–9, and HOXD1,3,4 and 8) are upregulated, especially in the old HDFs. The study successfully demonstrates the correlation between HOX genes and the skin aging process, providing strong evidence that HOX genes are proposed as a new marker for skin aging assessment. [ABSTRACT FROM AUTHOR]

Published
2024
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