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20 results on '"Ni, Sujie"'

1. Systematic analysis of ferroptosis-related long non-coding RNA predicting prognosis in patients with lung squamous cell carcinoma

Author

Yao, Ninghua, Zuo, Ling, Yan, Xiaodi, Qian, Jing, Sun, Jie, Xu, Huawei, Zheng, Feifei, Efird, Jimmy T., Kawagoe, Izumi, Wang, Yan, and Ni, Sujie

Subjects
Oncology, Original Article
Abstract

BACKGROUND: Ferroptosis is a novel iron-dependent cell death, and an increasing number of studies have shown that long non-coding RNA (lncRNAs) are involved in the ferroptosis process. However, studies on ferroptosis-related lncRNAs in lung squamous cell carcinoma (LUSC) are limited. In addition, the prognostic role of ferroptosis-related lncRNAs and their relationship with the immune microenvironment and methylation of LUSC is unclear. This study aimed to investigate the potential prognostic value of ferroptosis-related lncRNAs and their involved biological functions in LUSC. METHODS: The Cancer Genome Atlas (TCGA) database and the FerrDb website were used to obtain ferroptosis-related genes for LUSC. The “limma” R package and Pearson analysis were used to find ferroptosis-related lncRNAs. The biological functions of the characterized lncRNAs were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). We evaluated the prognostic power of this model using Kaplan-Meier analysis, receiver operating characteristic (ROC), and decision curve analysis (DCA). Univariate and multifactor Cox (proportional-hazards) risk model and a nomogram were produced using risk models and clinicopathological parameters for further verification. In addition, the relationship between characterized lncRNAs and tumor immune infiltration and methylation was also discussed. RESULTS: We identified 29 characterized lncRNAs to produce prognostic risk models. Kaplan-Meier analysis revealed the high-risk group was associated with poor prognosis in LUSC (P

Published
2022

6. Abstract P2-13-41: First-line pyrotinib plus trastuzumab and nab-paclitaxel for patients with HER2-positive advanced breast cancer

Author

Xie, Hui, primary, Li, Wei, additional, Yao, Yufeng, additional, Ni, Sujie, additional, Yi, Tongbo, additional, Cheng, Jinling, additional, Fang, Qi, additional, Zhang, Lei, additional, Zhou, Jun, additional, Wu, Xiaohong, additional, Wang, Chunbin, additional, Zhang, Yanan, additional, Qin, Jianwei, additional, Shao, Qing, additional, Zhao, Tao, additional, Huang, Xiaohong, additional, and Xu, Lingyun, additional

Published
2022
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18. Naked caspase 3 small interfering RNA is effective in cold preservation but not in autotransplantation of porcine kidneys

Author

Yang, Cheng, primary, Jia, Yichen, additional, Zhao, Tian, additional, Xue, Yinjia, additional, Zhao, Zitong, additional, Zhang, Junlin, additional, Wang, Jina, additional, Wang, Xuanchuan, additional, Qiu, Yongyin, additional, Lin, Miao, additional, Zhu, Dong, additional, Qi, Guisheng, additional, Qiu, Yue, additional, Tang, Qunye, additional, Rong, Ruiming, additional, Xu, Ming, additional, Ni, Sujie, additional, Lai, Bin, additional, Nicholson, Michael L., additional, Zhu, Tongyu, additional, and Yang, Bin, additional

Published
2013
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19. LncRNA MIR4435-2HG promotes proliferation, migration, invasion and epithelial mesenchymal transition via targeting miR-22-3p/TMEM9B in breast cancer.

Author

Ke J, Wang Q, Zhang W, Ni S, and Mei H

Abstract

Objective: Breast cancer, as a malignancy with the highest incidence and mortality in women, seriously threatens women's life and health. Pieces of evidence have suggested that long non-coding RNAs (lncRNAs) possess important roles in regulating the occurrence and development of breast cancer., Methods: RT-qPCR was used to explore the expression levels of MIR4435-2HG, miR-22-3p and TMEM9B in breast cancer tissues and cell lines. Cell viability, proliferation, migration and invasion were assessed by CCK-8 assay, Colony formation assay, Wound healing assay and Transwell assay, respectively. The effect of MIR4435-2HG on EMT progress was explored by Immunofluorescence assay and Western blot. RNA pull-down analysis and Dual-luciferase reporter assay were performed to validate the interaction between MIR4435-2HG and miR-22-3p, as well as miR-22-3p and TMEM9B., Results: MIR4435-2HG was notably up-regulated in breast cancer tissues and cell lines. Additionally, down-regulation of MIR4435-2HG restrained the viability, proliferation, migration, invasion and EMT of breast cancer cells. MiR-22-3p expression was down-regulated in breast cancer tissues and cell lines, and negatively associated with MIR4435-2HG expression. Over-expression of miR-22-3p obviously inhibited the viability, proliferation, migration, invasion and EMT of breast cancer cell lines. Furthermore, TMEM9B was up-regulated in breast cancer tissues and cell lines and negatively associated with miR-22-3p expression. TMEM9B inhibition partially restored the effects of MIR4435-2HG/miR-22-3p on the viability, proliferation, migration, invasion and EMT of breast cancer cell lines., Conclusion: MIR4435-2HG plays a potential tumor-promoting role in the occurrence and development of breast cancer, possibly by regulating the miR-22-3p/TMEM9B axis., Competing Interests: None., (AJTR Copyright © 2022.)

Published
2022

20. CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer.

Author

Ni S, Wang H, Zhu X, Wan C, Xu J, Lu C, Xiao L, He J, Jiang C, Wang W, and He Z

Subjects
Animals, Antimetabolites, Antineoplastic pharmacology, Biomarkers, Tumor genetics, Carcinoma, Pancreatic Ductal drug therapy, Carcinoma, Pancreatic Ductal genetics, Carcinoma, Pancreatic Ductal pathology, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, Fluorouracil pharmacology, Gene Expression Regulation, Neoplastic, Humans, Male, Mice, Nude, Middle Aged, Neoplasm Grading, Neoplasm Invasiveness, PTEN Phosphohydrolase genetics, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms genetics, Pancreatic Neoplasms pathology, Polycomb Repressive Complex 1 genetics, Signal Transduction, Time Factors, Transfection, Tumor Suppressor Proteins genetics, Biomarkers, Tumor metabolism, Carcinoma, Pancreatic Ductal enzymology, Cell Movement drug effects, Cell Proliferation drug effects, PTEN Phosphohydrolase metabolism, Pancreatic Neoplasms enzymology, Polycomb Repressive Complex 1 metabolism, Proto-Oncogene Proteins c-akt metabolism, Tumor Suppressor Proteins metabolism
Abstract

Chromobox protein homolog 7 (CBX7), one of the polycomb group (PcG) proteins, is a transcriptional repressor involved in the regulation of cell proliferation and senescence. In the present study, we showed that CBX7 negatively regulates the proliferation, viability, chemoresistance, and migration of pancreatic cancer cells. Overexpression of CBX7 significantly inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Depletion of CBX7 facilitated their growth. CBX7 also impaired the viability and chemoresistance of pancreatic cancer cells. Transwell assays showed that CBX7 reduces the migratory capacity of pancreatic cancer cells. Of note, CBX7 reduced PTEN/Akt signaling in pancreatic cancer cells by increasing PTEN transcription, suggesting involvement of PTEN/Akt pathway in the tumor suppressive activity of CBX7. In addition, immunohistochemical analysis the CBX7 and PTEN expression in 74 surgically resected pancreatic ductal adenocarcinoma (PDAC) specimens revealed that CBX7 expression is significantly downregulated in pancreatic ductal adenocarcinoma, compared to normal pancreatic tissues. Reduced expression of CBX7 and PTEN was associated with increased malignancy grade in pancreatic adenocarcinoma, whereas maintenance of CBX7 and PTEN expression showed a trend toward a longer survival. These findings suggest CBX7 is an important tumor suppressor that negatively modulates PTEN/Akt signaling during pancreatic tumorigenesis.

Published
2017
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