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1. Helicobacter pylori infection is associated with elevated galactose-deficient IgA1 in IgA nephropathy

Author

Xing-Zi Liu, Yue-Miao Zhang, Ni-Ya Jia, and Hong Zhang

Subjects
immunoglobulin a nephropathy, helicobacter pylori, cytotoxin-associated gene a/vacuolating cytotoxin a, galactose-deficient iga1, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Background Mucosal immunity plays an important role in the pathogenesis of IgA nephropathy (IgAN). This study aimed to investigate if infection of Helicobacter pylori (H. pylori), a common bacteria in the gastrointestinal tract, associated with IgAN. Methods This study included 261 patients with IgAN and 46 healthy controls. Clinical information and plasma samples were collected from patients and healthy controls. H. pylori infection was confirmed by western blot. Plasma IgA1 and galactose-deficient IgA1 (Gd-IgA1) levels were detected by specific enzyme-linked immunosorbent assay. Results Total H. pylori infection rates showed no statistical differences between IgAN patients and healthy controls, but the infection rates of type I H. pylori in IgAN patients were significantly higher than those in healthy controls (44.4 vs. 28.3%, p = 0.040). Compared with uninfected patients, the systolic blood pressure, 24-h proteinuria, and blood urea nitrogen levels were significantly higher in patients with H. pylori infection (126.0 ± 15.5 vs. 119.6 ± 14.5 mmHg, p = 0.010; 1.8 ± 2.7 vs. 1.2 ± 1.4 g/24h, p = 0.013; 7.9 ± 5.4 vs. 6.7 ± 3.9 μmol/L, p = 0.042), especially in patients with type I infection (126.5 ± 15.4 vs. 119.6 ± 14.5 mmHg, p = 0.002; 1.9 ± 2.9 vs. 1.2 ± 1.4 g/24 h, p = 0.033; 8.1 ± 5.6 vs. 6.7 ± 3.9 μmol/L, p = 0.041). Similarly, patients with IgAN and type I H. pylori infection showed higher plasma Gd-IgA1 levels than uninfected patients (5.5 ± 2.2 vs. 4.5 ± 2.2 μg/mL, p = 0.037). Conclusions Virulent type I H. pylori infection is more common in patients with IgAN. Patients with IgAN and type I H. pylori infection showed lower renal function and higher underglycosylation of plasma IgA1.

Published
2020
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2. Weighted Gene Co-expression Network Analysis Reveals Different Immunity but Shared Renal Pathology Between IgA Nephropathy and Lupus Nephritis

Author

Ni-Ya Jia, Xing-Zi Liu, Zhao Zhang, and Hong Zhang

Subjects
IgA nephropathy, lupus nephritis, weighted gene co-expression network analysis, systematic immunity, kidney immunity, Genetics, QH426-470
Abstract

Both IgA nephropathy (IgAN) and lupus nephritis (LN) are immunity-related diseases with a complex, polygenic, and pleiotropic genetic architecture. However, the mechanism by which the genetic variants impart immunity or renal dysfunction remains to be clarified. In this study, using gene expression datasets as a quantitative readout of peripheral blood mononuclear cell (PBMC)- and kidney-based molecular phenotypes, we analyzed the similarities and differences in the patterns of gene expression perturbations associated with the systematic and kidney immunity in IgAN and LN. Original gene expression datasets for PBMC, glomerulus, and tubule from IgAN and systemic lupus erythematosus (SLE) patients as well as corresponding controls were obtained from the Gene Expression Omnibus (GEO) database. The similarities and differences in the expression patterns were detected according to gene differential expression. Weighted gene co-expression network analysis (WGCNA) was used to cluster and screen the co-expressed gene modules. The disease correlations were then identified by cell-specific and functional enrichment analyses. By combining these results with the genotype data, we identified the differentially expressed genes causatively associated with the disease. There was a significant positive correlation with the kidney expression profile, but no significant correlation with PBMC. Three co-expression gene modules were screened by WGCNA and enrichment analysis. Among them, blue module was enriched for glomerulus and podocyte (P < 0.05) and positively correlated with both diseases (P < 0.05), mainly via immune regulatory pathways. Pink module and purple module were enriched for tubular epithelium and correlated with both diseases (P < 0.05) through predominant cell death and extracellular vesicle pathways, respectively. In genome-wide association study (GWAS) enrichment analysis, blue module was identified as the high-risk gene module that distinguishes LN from SLE and contains PSMB8 and PSMB9, the susceptibility genes for IgAN. In conclusion, IgAN and LN showed different systematic immunity but similarly abnormal immunity in kidney. Immunological pathways may be involved in the glomerulopathy and cell death together with the extracellular vesicle pathway, which may be involved in the tubular injury in both diseases. Blue module may cover the causal susceptibility gene for IgAN and LN.

Published
2021
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4. Helicobacter pylori infection is associated with elevated galactose-deficient IgA1 in IgA nephropathy

Author

Hong Zhang, Yue-miao Zhang, Ni-Ya Jia, and Xing-Zi Liu

Subjects
Helicobacter pylori infection, 030232 urology & nephrology, 030204 cardiovascular system & hematology, lcsh:RC870-923, urologic and male genital diseases, Critical Care and Intensive Care Medicine, Nephropathy, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, immunoglobulin a nephropathy, Immunoglobulin A Nephropathy, Mucosal immunity, biology, business.industry, General Medicine, Helicobacter pylori, lcsh:Diseases of the genitourinary system. Urology, bacterial infections and mycoses, medicine.disease, biology.organism_classification, chemistry, Nephrology, cytotoxin-associated gene a/vacuolating cytotoxin a, Galactose, galactose-deficient iga1, Immunology, Clinical Study, helicobacter pylori, business, Research Article
Abstract

Mucosal immunity plays an important role in the pathogenesis of IgA nephropathy (IgAN). This study aimed to investigate if infection of Helicobacter pylori (H. pylori), a common bacteria in the gastrointestinal tract, associated with IgAN. This study included 261 patients with IgAN and 46 healthy controls. Clinical information and plasma samples were collected from patients and healthy controls. H. pylori infection was confirmed by western blot. Plasma IgA1 and galactose-deficient IgA1 (Gd-IgA1) levels were detected by specific enzyme-linked immunosorbent assay. Total H. pylori infection rates showed no statistical differences between IgAN patients and healthy controls, but the infection rates of type I H. pylori in IgAN patients were significantly higher than those in healthy controls (44.4 vs. 28.3%, p = 0.040). Compared with uninfected patients, the systolic blood pressure, 24-h proteinuria, and blood urea nitrogen levels were significantly higher in patients with H. pylori infection (126.0 ± 15.5 vs. 119.6 ± 14.5 mmHg, p = 0.010; 1.8 ± 2.7 vs. 1.2 ± 1.4 g/24h, p = 0.013; 7.9 ± 5.4 vs. 6.7 ± 3.9 μmol/L, p = 0.042), especially in patients with type I infection (126.5 ± 15.4 vs. 119.6 ± 14.5 mmHg, p = 0.002; 1.9 ± 2.9 vs. 1.2 ± 1.4 g/24 h, p = 0.033; 8.1 ± 5.6 vs. 6.7 ± 3.9 μmol/L, p = 0.041). Similarly, patients with IgAN and type I H. pylori infection showed higher plasma Gd-IgA1 levels than uninfected patients (5.5 ± 2.2 vs. 4.5 ± 2.2 μg/mL, p = 0.037). Virulent type I H. pylori infection is more common in patients with IgAN. Patients with IgAN and type I H. pylori infection showed lower renal function and higher underglycosylation of plasma IgA1.

Published
2020

5. PRIMARY AND SECONDARY GLOMERULONEPHRITIDES 1

Author

Masayuki Iyoda, Taihei Suzuki, Jung Eun Lee, Margherita Conrieri, Angel Sevillano, Katsuyuki Nagatoya, Shankar Prasad Nagaraju, Nicoletta Mezzina, Augusta Praça, A. Malesci, Bjørn Egil Vikse, Tajana Zeljkovic Vrkic, Fumihiko Sasai, Giuseppe Paolo Segoloni, Maki Shinzawa, Terumasa Hayashi, Yutaka Yamaguchi, Maria Elena Donadio, Inês Ferreira, Ioanna Labropoulou, Luca Vergano, Yoshikuni Nagayama, Manuel A Podestà, Guida Meneses, Takayuki Kuragano, Gisele V. Fernandes, Manohar Bairy, Yasuyuki Nagasawa, Ayse Serra Artan, Vedran Premuzic, Barbara Trezzi, Carla Guidi, Manuel Pestana, Makoto Watanabe, Donatella Vizza, Francisco Remédio, Rune Bjørneklett, Niranjan Ambekar, Evangelina Mérida, Narayan Prasad, Ana Cristina Matos, George Toulkeridis, In Mi Han, Enrique Morales, Mohit Kumar Rai, Federica Chiale, Kenichi Sumida, Ann Merethe Vågane, E. Mariz, Adrian Zugravu, Andreas Kronbichler, Michael A. Rudnicki, Praga Manuel, Maria Skoularopoulou, Maria Paola Puccinelli, Mustafa Güllülü, Helena Viana, Loredana Colla, Vasudeva Guddattu, Sung-Bae Park, Sung Jin Moon, Eduardo Gutiérrez, Hirokatsu Atsumi, Junichi Hoshino, Rajeevalochana Parthasarathy, Nimet Aktas, Renzo Bonofilgio, Carla Henriques, Ana Huerta, Jelena Kos, David Cucchiari, Gener Ismail, Renato Alberto Sinico, Anna Varberg Reisæter, Hideki Yamaya, Iuliana Andreiana, Atsushi Yamauchi, Bernardo Faria, Francesca Maria Bosetti, Noriko Hayami, Vincenzo Cantaluppi, Yoshitaka Isaka, Swapnil Karnik, Aydin Turkmen, Alexei Smirnov, Ljiljana Fodor, Jinhyuk Paek, Alberto Boido, Shinichi Uchida, Abdulmecit Yildiz, Takanori Shibata, Sei Sasaki, Xiao-Yan Wei, Ravindra Prabhu, Tiziana Stellato, Roser Torra, Eunah Hwang, Kazuyuki Tasaki, Luigi Biancone, Gutierrez-Solis Elena, Clarissa J. B. Carvalho, Gabriel Mircescu, Ana Teresa Nunes, Elisabet Ars, Tomokazu Okado, Hui Wang, Vanja Ivković, Tushar Anil Dighe, Katsuhito Ihara, Norifumi Hayashi, Roxana Jurubita, Aysegul Oruc, Yasar Caliskan, Mehmet Sukru Sever, Atul Sajgure, Aikaterini Papagianni, Katarzyna Koscielska-Kasprzak, Francesca Leone, Mario Laganović, Archana Buch, Daisuke Komukai, Carina Ferreira, Olga Galkina, Marian Klinger, Sandra Karanović, Manuela Bianciotto, Srinivas Kosuru, Maria Céu Santos, Maurizio Gallieni, Manuel Praga, Yuan-Qing Tian, Ken Iseri, Peter Påhlsson, Kenmei Takaichi, Vikas Agarwal, Manuel Burdese, Aritoshi Kida, Giulio Mengozzi, Giovanni Camussi, Yasutaka Yamamoto, Tomohiro Saito, Seiichi Matsuo, Enyu Imai, Yuki Shindo-Hirai, Edite Pereira, Nida Oztop, Gert Mayer, Tatemitsu Rai, Rosanna Coppo, Hiroshi Okuyama, Dong Ho Shin, Soichiro Iimori, Danilo Lofaro, Hiroki Adachi, Yasemin Ozluk, Maria Alina Gomes de Mattos Cavalcante, Michael C. Carlsson, Bulent Gul, Abhay Sadre, Shunsuke Goto, Vasilii Sipovskii, Kei Fukami, Hiroki Nishiwaki, Tatsuya Suwabe, Daniela Finocchietti, Yuki Matsui, Takshi Nakanishi, Ashwini Sharma, Teresa Papalia, Marijana Cˇorić, Marco D'Amico, Caro-Espada Paula Jara, Francesco Mollica, Licia Peruzzi, Yukihiro Wada, Roberta Camilla, Agata Mollica, E. O. Bogdanova, Raluca Bobeica, Cai-Li Wang, Eugen Mandache, Francesco Reggiani, Joaquim Calado, Li Lv, Elena Saganova, Fernanda Carvalho, Halil Yazici, Yan-Hui Zhang, Elisa Loiacono, Christos Bantis, Teresa Cavero, Salvatore Badalamenti, Hakon Leffler, Sigrid Lundberg, Tarun Jeloka, Ligia Petrescu, Luca Besso, Alline S. A. Oliveira, Stratis Kasimatis, Thomas Knoop, Davide Medica, Germana Daidola, E. Hernandez, Mana Yahiro, Rojas-Rivera Jorge Enrique, João M. Frazão, Kouki Mise, Toshiaki Suzuki, Yoshihiro Kuno, Atul Mulay, Jun Ito, Katarzyna Gniewek, George Efstratiadis, Marijana Ćorić, Jara Caro, Maria Stangou, Aysun Aksoy, Fernando Nolasco, Katarzyna Jakuszko, Paolo Gigliotti, Tae Hyun Yoo, Takeshi Hasegawa, Hideki Fujii, Ricardo Neto, Simona Stancu, Susana Sampaio, Camila Barbosa L Oliveira, Sindhura Lakshmi Koulmane Laxminarayana, Alaattin Yildiz, Shigeo Hara, Kei Matsumoto, Ludmila Taran, Nikoleta Maria Kouri, Shinichi Nishi, Andreea Avram, Zivka Dika, Nobuharu Kaneshima, Charan Bhadrappa Bale, Gian Marco Ghiggeri, Ashio Yoshimura, Lei Nan, Rachele Gallo, Keiji Fujimoto, Alessandro Amore, Mårten Segelmark, Luís H. B. C. Sette, Francesca Brunini, Bojan Jelaković, Lucila Maria Valente, Ryohei Yamamoto, Andreea Andronesi, Julia Kerschbaum, Inna Lastauka, Mohamed R. Daha, Akhilesh Jaiswal, Ni-Ya Jia, Jayraj Korpe, Shinichi Akiyama, Domenico Santoro, Marc A. Seelen, Ebru Acikgoz, Shoichi Maruyama, Anna Perri, Hitoshi Yokoyama, Magdalena Krajewska, Brijesh Yadav, Hyungjong Kim, Irina Zubina, Tatsuya Shoji, Yoshifumi Ubara, Claudio Angelini, Margareta Fištrek Prlić, Ian Proletov, Kentaro Nakai, Isin Kilicaslan, Antonella Radice, Prachi Kate, Sayuri Hamahata, Jose Antonio Moreno, and Marijana Zivko

Subjects
Transplantation, medicine.medical_specialty, Pediatrics, Primary (chemistry), Nephrology, business.industry, Alternative medicine, medicine, business, Intensive care medicine
Published
2014

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