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213 results on '"Niangaly, Amadou"'

1. Gene expression analyses reveal differences in children’s response to malaria according to their age

Author

Tebben, Kieran, Yirampo, Salif, Coulibaly, Drissa, Koné, Abdoulaye K., Laurens, Matthew B., Stucke, Emily M., Dembélé, Ahmadou, Tolo, Youssouf, Traoré, Karim, Niangaly, Amadou, Berry, Andrea A., Kouriba, Bourema, Plowe, Christopher V., Doumbo, Ogobara K., Lyke, Kirsten E., Takala-Harrison, Shannon, Thera, Mahamadou A., Travassos, Mark A., and Serre, David

Published
2024
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2. Children with hemoglobin C or S trait have low serologic responses to a subset of malaria variant surface antigens

Author

Bailey, Rachel D., Lawton, Jonathan G., Niangaly, Amadou, Stucke, Emily M., Bailey, Jason A., Berry, Andrea A., Ouattara, Amed, Coulibaly, Drissa, Lyke, Kirsten E., Laurens, Matthew B., Zhou, Albert E., Pablo, Jozelyn, Jasinskas, Algis, Nakajima, Rie, Adams, Matthew, Takala-Harrison, Shannon, Kouriba, Bourema, Kone, Abdoulaye K., Guindo, Aldiouma, Rowe, J. Alexandra, Diallo, Dapa A., Doumbo, Ogobara K., Felgner, Philip L., Plowe, Christopher V., Thera, Mahamadou A., and Travassos, Mark A.

Published
2024
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3. Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination

Author

Bailey, Jason A, Berry, Andrea A, Travassos, Mark A, Ouattara, Amed, Boudova, Sarah, Dotsey, Emmanuel Y, Pike, Andrew, Jacob, Christopher G, Adams, Matthew, Tan, John C, Bannen, Ryan M, Patel, Jigar J, Pablo, Jozelyn, Nakajima, Rie, Jasinskas, Algis, Dutta, Sheetij, Takala-Harrison, Shannon, Lyke, Kirsten E, Laurens, Matthew B, Niangaly, Amadou, Coulibaly, Drissa, Kouriba, Bourema, Doumbo, Ogobara K, Thera, Mahamadou A, Felgner, Philip L, and Plowe, Christopher V

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Biotechnology, Malaria, Vector-Borne Diseases, Immunization, Infectious Diseases, Rare Diseases, HIV/AIDS, Vaccine Related, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, Infection, Good Health and Well Being, Antibodies, Protozoan, Antibody Formation, Antigens, Protozoan, Malaria Vaccines, Malaria, Falciparum, Membrane Proteins, Plasmodium falciparum, Protozoan Proteins
Abstract

Vaccines based on Plasmodium falciparum apical membrane antigen 1 (AMA1) have failed due to extensive polymorphism in AMA1. To assess the strain-specificity of antibody responses to malaria infection and AMA1 vaccination, we designed protein and peptide microarrays representing hundreds of unique AMA1 variants. Following clinical malaria episodes, children had short-lived, sequence-independent increases in average whole-protein seroreactivity, as well as strain-specific responses to peptides representing diverse epitopes. Vaccination resulted in dramatically increased seroreactivity to all 263 AMA1 whole-protein variants. High-density peptide analysis revealed that vaccinated children had increases in seroreactivity to four distinct epitopes that exceeded responses to natural infection. A single amino acid change was critical to seroreactivity to peptides in a region of AMA1 associated with strain-specific vaccine efficacy. Antibody measurements using whole antigens may be biased towards conserved, immunodominant epitopes. Peptide microarrays may help to identify immunogenic epitopes, define correlates of vaccine protection, and measure strain-specific vaccine-induced antibodies.

Published
2020

4. Serologic responses to the PfEMP1 DBL-CIDR head structure may be a better indicator of malaria exposure than those to the DBL-α tag

Author

Stucke, Emily M, Niangaly, Amadou, Berry, Andrea A, Bailey, Jason A, Coulibaly, Drissa, Ouattara, Amed, Lyke, Kirsten E, Laurens, Matthew B, Dara, Antoine, Adams, Matthew, Pablo, Jozelyn, Jasinskas, Algis, Nakajima, Rie, Zhou, Albert E, Agrawal, Sonia, Friedman-Klabanoff, DeAnna J, Takala-Harrison, Shannon, Kouriba, Bourema, Kone, Abdoulaye K, Rowe, J Alexandra, Doumbo, Ogobara K, Felgner, Philip L, Thera, Mahamadou A, Plowe, Christopher V, and Travassos, Mark A

Subjects
Clinical Research, HIV/AIDS, Malaria, Infectious Diseases, Pediatric, Rare Diseases, Vector-Borne Diseases, Infection, Good Health and Well Being, Adult, Antigens, Protozoan, Child, Child, Preschool, Conserved Sequence, Humans, Infant, Malaria, Falciparum, Middle Aged, Plasmodium falciparum, Protein Structure, Tertiary, Protozoan Proteins, Young Adult, var genes, PfEMP1, Immunity, Seroreactivity, Microarray, Microbiology, Medical Microbiology, Public Health and Health Services, Tropical Medicine
Abstract

BackgroundPlasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-terminal constitutive domain in a PfEMP1 is the Duffy binding-like alpha (DBL-α) domain, which contains a 300 to 400 base pair region unique to each particular protein (the DBL-α "tag"). This DBL-α tag has been used as a marker of PfEMP1 diversity and serologic responses in malaria-exposed populations. In this study, using sera from a malaria-endemic region, responses to DBL-α tags were compared to responses to the corresponding entire DBL-α domain (or "parent" domain) coupled with the succeeding cysteine-rich interdomain region (CIDR).MethodsA protein microarray populated with DBL-α tags, the parent DBL-CIDR head structures, and downstream PfEMP1 protein fragments was probed with sera from Malian children (aged 1 to 6 years) and adults from the control arms of apical membrane antigen 1 (AMA1) vaccine clinical trials before and during a malaria transmission season. Serological responses to the DBL-α tag and the DBL-CIDR head structure were measured and compared in children and adults, and throughout the season.ResultsMalian serologic responses to a PfEMP1's DBL-α tag region did not correlate with seasonal malaria exposure, or with responses to the parent DBL-CIDR head structure in either children or adults. Parent DBL-CIDR head structures were better indicators of malaria exposure.ConclusionsLarger PfEMP1 domains may be better indicators of malaria exposure than short, variable PfEMP1 fragments such as DBL-α tags. PfEMP1 head structures that include conserved sequences appear particularly well suited for study as serologic predictors of malaria exposure.

Published
2019

6. PfSPZ-CVac malaria vaccine demonstrates safety among malaria-experienced adults: A randomized, controlled phase 1 trial

Author

Coulibaly, Drissa, Kone, Abdoulaye K., Traore, Karim, Niangaly, Amadou, Kouriba, Bourema, Arama, Charles, Zeguime, Amatigue, Dolo, Amagana, Lyke, Kirsten E., Plowe, Christopher V., Abebe, Yonas, Potter, Gail E., Kennedy, Jessie K., Galbiati, Shirley M., Nomicos, Effie, Deye, Gregory A., Richie, Thomas L., James, Eric R., KC, Natasha, Sim, B. Kim Lee, Hoffman, Stephen L., Doumbo, Ogobara K., Thera, Mahamadou A., and Laurens, Matthew B.

Published
2022
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7. Antibodies to Peptides in Semiconserved Domains of RIFINs and STEVORs Correlate with Malaria Exposure

Author

Zhou, Albert E, Berry, Andrea A, Bailey, Jason A, Pike, Andrew, Dara, Antoine, Agrawal, Sonia, Stucke, Emily M, Ouattara, Amed, Coulibaly, Drissa, Lyke, Kirsten E, Laurens, Matthew B, Adams, Matthew, Takala-Harrison, Shannon, Pablo, Jozelyn, Jasinskas, Algis, Nakajima, Rie, Niangaly, Amadou, Kouriba, Bourema, Kone, Abdoulaye K, Rowe, J Alexandra, Doumbo, Ogobara K, Thera, Mahamadou A, Patel, Jigar J, Tan, John C, Felgner, Philip L, Plowe, Christopher V, and Travassos, Mark A

Subjects
Infectious Diseases, Pediatric, Clinical Research, Rare Diseases, Malaria, Vector-Borne Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Adolescent, Adult, Age Factors, Antibodies, Protozoan, Antigens, Protozoan, Child, Child, Preschool, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Endemic Diseases, Female, Humans, Immunity, Innate, Infant, Interspersed Repetitive Sequences, Male, Mali, Middle Aged, Peptides, Plasmodium falciparum, Protein Array Analysis, Young Adult, RIFIN, STEVOR, malaria, microarrays, peptide, semiconserved domain, severe malaria, variant surface antigen, Plasmodium falciparum, Immunology, Microbiology
Abstract

The repetitive interspersed family (RIFIN) and the subtelomeric variable open reading frame (STEVOR) family represent two of three major Plasmodium falciparum variant surface antigen families involved in malaria pathogenesis and immune evasion and are potential targets in the development of natural immunity. Protein and peptide microarrays populated with RIFINs and STEVORs associated with severe malaria vulnerability in Malian children were probed with adult and pediatric sera to identify epitopes that reflect malaria exposure. Adult sera recognized and reacted with greater intensity to all STEVOR proteins than pediatric sera did. Serorecognition of and seroreactivity to peptides within the semiconserved domain of STEVORs increased with age and seasonal malaria exposure, while serorecognition and seroreactivity increased for the semiconserved and second hypervariable domains of RIFINs only with age. Serologic responses to RIFIN and STEVOR peptides within the semiconserved domains may play a role in natural immunity to severe malaria.IMPORTANCE Malaria, an infectious disease caused by the parasite Plasmodium falciparum, causes nearly 435,000 deaths annually worldwide. RIFINs and STEVORs are two variant surface antigen families that are involved in malaria pathogenesis and immune evasion. Recent work has shown that a lack of humoral immunity to these proteins is associated with severe malaria vulnerability in Malian children. This is the first study to have compared serologic responses of children and adults to RIFINs and STEVORs in settings of malaria endemicity and to examine such serologic responses before and after a clinical malaria episode. Using microarrays, we determined that the semiconserved domains in these two parasite variant surface antigen families harbor peptides whose seroreactivity reflects malaria exposure. A similar approach has the potential to illuminate the role of variant surface antigens in the development of natural immunity to clinical malaria. Potential vaccines for severe malaria should include consideration of peptides within the semiconserved domains of RIFINs and STEVORs.

Published
2019

8. Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial

Author

Sissoko, Mahamadou S, Healy, Sara A, Katile, Abdoulaye, Zaidi, Irfan, Hu, Zonghui, Kamate, Bourama, Samake, Yacouba, Sissoko, Kourane, Mwakingwe-Omari, Agnes, Lane, Jacquelyn, Imeru, Alemush, Mohan, Rathy, Thera, Ismaila, Guindo, Cheick Oumar, Dolo, Amagana, Niare, Karamoko, Koïta, Fanta, Niangaly, Amadou, Rausch, Kelly M, Zeguime, Amatigue, Guindo, Merepen A, Bah, Aissatou, Abebe, Yonas, James, Eric R, Manoj, Anita, Murshedkar, Tooba, KC, Natasha, Sim, B Kim Lee, Billingsley, Peter F, Richie, Thomas L, Hoffman, Stephen L, Doumbo, Ogobara, and Duffy, Patrick E

Published
2022
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9. Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets

Author

Travassos, Mark A, Niangaly, Amadou, Bailey, Jason A, Ouattara, Amed, Coulibaly, Drissa, Lyke, Kirsten E, Laurens, Matthew B, Pablo, Jozelyn, Jasinskas, Algis, Nakajima, Rie, Berry, Andrea A, Adams, Matthew, Jacob, Christopher G, Pike, Andrew, Takala-Harrison, Shannon, Liang, Li, Kouriba, Bourema, Kone, Abdoulaye K, Rowe, J Alexandra, Moulds, JoAnn, Diallo, Dapa A, Doumbo, Ogobara K, Thera, Mahamadou A, Felgner, Philip L, and Plowe, Christopher V

Subjects
Malaria, Pediatric, Brain Disorders, Rare Diseases, Infectious Diseases, Vector-Borne Diseases, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Anemia, Antigens, Protozoan, Case-Control Studies, Child, Preschool, Female, Humans, Infant, Malaria, Cerebral, Malaria, Falciparum, Male, Plasmodium falciparum
Abstract

Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or "lacunae", in immunity to these Plasmodium falciparum antigens in children with severe malaria would improve our understanding of vulnerability to severe malaria and how protective immunity develops. Using a protein microarray with 179 antigen variants from three VSA families as well as more than 300 variants of three other blood stage P. falciparum antigens, reactivity was measured in sera from Malian children with cerebral malaria or severe malarial anaemia and age-matched controls. Sera from children with severe malaria recognized fewer extracellular PfEMP1 fragments and were less reactive to specific fragments compared to controls. Following recovery from severe malaria, convalescent sera had increased reactivity to certain non-CD36 binding PfEMP1s, but not other malaria antigens. Sera from children with severe malarial anaemia reacted to fewer VSAs than did sera from children with cerebral malaria, and both of these groups had lacunae in their seroreactivity profiles in common with children who had both cerebral malaria and severe malarial anaemia. This microarray-based approach may identify a subset of VSAs that could inform the development of a vaccine to prevent severe disease or a diagnostic test to predict at-risk children.

Published
2018

10. Dynamics of Pfcrt K76T and Pfmdr1N86Y fifteen years after the withdrawal of chloroquine in Mali

Author

Dama, Souleymane, primary, Diakite, Bassirou, additional, Dinkorma, Ouologuem T, additional, Niangaly, Amadou, additional, Kone, Abdoulaye K, additional, Dara, Antoine, additional, Kone, Aminatou, additional, Bamadio, Amadou, additional, Kodio, Aly, additional, Doumbia, Diagassan, additional, Djimde, Moussa, additional, Doumbia, Moussa, additional, Tekete, Mamadou, additional, Fofana, Bakary, additional, Lamine, Alhousseini Mohamed, additional, Dara, Niawanlou, additional, Sidibe, Bouran, additional, Maiga, Hamma, additional, and Djimde, Abdoulaye A, additional

Published
2024
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11. Protection from Malaria after Pre-Conception PfSPZ Vaccine

Author

Diawara, Halimatou, primary, Healy, Sara A., additional, Mwakingwe-Omari, Agnes, additional, Issiaka, Djibrilla, additional, Diallo, Aye, additional, Lane, Jacquelyn, additional, Traore, Seydou, additional, Soumbounou, Ibrahim H., additional, Gaoussou, Santara, additional, Traore, Moussa, additional, Samassekou, Mamoudou, additional, Dicko, Oumar Mohamed, additional, N'Diaye, Oulematou, additional, Sidibe, Youssoufa, additional, Zaidi, Irfan, additional, Marte-Salcedo, Omely, additional, Mahamar, Almahamoudou, additional, Attaher, Oumar, additional, Niambele, Sidi M., additional, Diarra, Kalifa, additional, Cisse, Kadidia Baba, additional, Fried, Michal, additional, Wylie, Blair J., additional, Mohan, Rathy, additional, Doan, Viyada, additional, Doritchamou, Justin Y. A., additional, Tran, Daniel, additional, Neal, Jillian, additional, Gupta, Mahesh, additional, Diarra, Ibrahim, additional, Niangaly, Amadou, additional, Dolo, Amagana, additional, Diarra, Balla, additional, Bengaly, Karim, additional, Robert, Morrison, additional, Wang, Jing, additional, Hu, Zonghui, additional, Rausch, Kelly M., additional, Zeguime, Amatigue, additional, Doucoure, M'Bouye, additional, Dembele, Adama, additional, Samake, Idrissa, additional, Diarra, Bakary Soumana, additional, Bah, Aissatou, additional, Abebe, Yonas, additional, James, Eric R., additional, Manoj, Anita, additional, Murshedkar, Tooba, additional, KC, Natasha, additional, Sim, Kim Lee B., additional, Billingsley, Peter F., additional, Richie, Thomas L., additional, Hoffman, Stephen, additional, Dicko, Alassane, additional, and Duffy, Patrick Emmet, additional

Published
2024
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12. The Pan African Vivax and Ovale Network (PAVON): Refocusing on Plasmodium vivax, ovale and asymptomatic malaria in sub-Saharan Africa

Author

Quaye, Isaac K., Aleksenko, Larysa, Oeuvray, Claude, Yewhalaw, Delenasaw, Duah, Nancy, Gyan, Ben, Haiyambo, Daniel H., Dongho, Ghyslaine Bruna Djeunang, Torgby, Ruth-Ayanful, Amoah, Linda, Hamid, Mahdi Abdel, Worku, Solomon, Bahiti, Assefa Ashenafi, Pasquale, Harriet Akello, Bitshi, Mimie, Troare, Isidore, Diarra, Amidou, Njunju, Eric, Cisse, Mamoudou, Soulama, Issiaka, Savadogo, Ragnessi Justin, Issifou, Saadou, Niangaly, Amadou, Dembele, Laurent, and Greco, Beatrice

Published
2021
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13. Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali.

Author

Doucoure, M’Bouye, Zeguime, Amatigue, Niangaly, Amadou, Guindo, Merepen A., Doritchamou, Justin Y. A., Assadou, Mahamadoun H., Katile, Abdoulaye, Kanoute, Moussa B., Perou, Sidiki, Ouattara, Adama, Sanogo, Sintry, Ouologuem, Boucary, Traore, Souleymane, Dao, Bakary, Dembele, Drissa, Kone, Mamady, Kamate, Bourama, Sissoko, Kourane, Sankare, Seydou, and Diarra, Sadio

Published
2024
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14. Gene expression analyses reveal differences in children's response to malaria according to their age

Author

Tebben, Kieran, primary, Yirampo, Salif, additional, Coulibaly, Drissa, additional, Kone, Abdoulaye Kassoum, additional, Laurens, Matthew B., additional, Stucke, Emily, additional, Dembele, Amadou, additional, Tolo, Youssouf, additional, Traore, Karim, additional, Niangaly, Amadou, additional, Berry, Andrea A., additional, Kouriba, Bourema, additional, Plowe, Christopher V, additional, Lyke, Kirsten E., additional, Takala-Harrison, Shannon, additional, Travassos, Mark A., additional, and Serre, David, additional

Published
2023
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15. Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s

Author

Tewey, Madison A., primary, Coulibaly, Drissa, additional, Lawton, Jonathan G., additional, Stucke, Emily M., additional, Zhou, Albert E., additional, Berry, Andrea A., additional, Bailey, Jason A., additional, Pike, Andrew, additional, Dara, Antoine, additional, Ouattara, Amed, additional, Lyke, Kirsten E., additional, Ifeonu, Olukemi, additional, Laurens, Matthew B., additional, Adams, Matthew, additional, Takala-Harrison, Shannon, additional, Niangaly, Amadou, additional, Kouriba, Bourema, additional, Koné, Abdoulaye K., additional, Rowe, J. Alexandra, additional, Doumbo, Ogobara K., additional, Patel, Jigar J., additional, Tan, John C., additional, Felgner, Philip L., additional, Plowe, Christopher V., additional, Thera, Mahamadou A., additional, and Travassos, Mark A., additional

Published
2023
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17. Immunogenomic profile at baseline predicts host susceptibility to clinical malaria

Author

Mbambo, Gillian, primary, Dwivedi, Ankit, additional, Ifeonu, Olukemi O., additional, Munro, James B., additional, Shrestha, Biraj, additional, Bromley, Robin E., additional, Hodges, Theresa, additional, Adkins, Ricky S., additional, Kouriba, Bourema, additional, Diarra, Issa, additional, Niangaly, Amadou, additional, Kone, Abdoulaye K., additional, Coulibaly, Drissa, additional, Traore, Karim, additional, Dolo, Amagana, additional, Thera, Mahamadou A., additional, Laurens, Matthew B., additional, Doumbo, Ogobara K., additional, Plowe, Christopher V., additional, Berry, Andrea A., additional, Travassos, Mark, additional, Lyke, Kirsten E., additional, and Silva, Joana C., additional

Published
2023
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18. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Band, Gavin, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Clarke, Geraldine, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, deVries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hubbart, Christina, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jeffreys, Anna, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Le, Si, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Ly, Alioune, Macharia, Alexander, MacInnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Kevin, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, McCreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Peshu, Norbert, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Rowlands, Kate, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, SanJoaquin, Miguel, Sepúlveda, Nuno, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Uyoga, Sophie, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, Ndila, Carolyne M, Macharia, Alexander W, Nyutu, Gideon, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Clark, Taane G, Kariuki, Silvia, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, and Williams, Thomas N

Published
2018
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20. IFNγ, TNFα polymorphisms and IFNγ serum levels are associated with the clearance of drug-resistant P. falciparum in Malian children

Author

Kouriba, Bourema, primary, Arama, Charles, additional, Ouologuem, Dinkorma T., additional, Cissoko, Yacouba, additional, Diakite, Mahamadou, additional, Beavogui, Abdoul Habib, additional, Wele, Mamadou, additional, Tekete, Mamadou, additional, Fofana, Bakary, additional, Dama, Souleymane, additional, Maiga, Hamma, additional, Kone, Aminatou, additional, Niangaly, Amadou, additional, Diarra, Issa, additional, Daou, Modibo, additional, Guindo, Ando, additional, Traore, Karim, additional, Coulibaly, Drissa, additional, Kone, Abdoulaye K., additional, Dicko, Alassane, additional, Clark, Taane G., additional, Doumbo, Ogobara K., additional, and Djimde, Abdoulaye, additional

Published
2023
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21. Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial

Author

Sissoko, Mahamadou S, Healy, Sara A, Katile, Abdoulaye, Omaswa, Freda, Zaidi, Irfan, Gabriel, Erin E, Kamate, Bourama, Samake, Yacouba, Guindo, Merepen A, Dolo, Amagana, Niangaly, Amadou, Niaré, Karamoko, Zeguime, Amatigue, Sissoko, Kourane, Diallo, Hama, Thera, Ismaila, Ding, Kelly, Fay, Michael P, O'Connell, Elise M, Nutman, Thomas B, Wong-Madden, Sharon, Murshedkar, Tooba, Ruben, Adam J, Li, Minglin, Abebe, Yonas, Manoj, Anita, Gunasekera, Anusha, Chakravarty, Sumana, Sim, B Kim Lee, Billingsley, Peter F, James, Eric R, Walther, Michael, Richie, Thomas L, Hoffman, Stephen L, Doumbo, Ogobara, and Duffy, Patrick E

Published
2017
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22. Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A

Author

Berry, Andrea A., Gottlieb, Eric R., Kouriba, Bourema, Diarra, Issa, Thera, Mahamadou A., Dutta, Sheetij, Coulibaly, Drissa, Ouattara, Amed, Niangaly, Amadou, Kone, Abdoulaye K., Traore, Karim, Tolo, Youssouf, Mishcherkin, Vladimir, Soisson, Lorraine, Diggs, Carter L., Blackwelder, William C., Laurens, Matthew B., Sztein, Marcelo B., Doumbo, Ogobara K., Plowe, Christopher V., and Lyke, Kirsten E.

Published
2019
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23. Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles

Author

Tebben, Kieran, primary, Yirampo, Salif, additional, Coulibaly, Drissa, additional, Koné, Abdoulaye K., additional, Laurens, Matthew B., additional, Stucke, Emily M., additional, Dembélé, Ahmadou, additional, Tolo, Youssouf, additional, Traoré, Karim, additional, Niangaly, Amadou, additional, Berry, Andrea A., additional, Kouriba, Bourema, additional, Plowe, Christopher V., additional, Doumbo, Ogobara K., additional, Lyke, Kirsten E., additional, Takala-Harrison, Shannon, additional, Thera, Mahamadou A., additional, Travassos, Mark A., additional, and Serre, David, additional

Published
2023
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24. Strain-specific Plasmodium falciparum multifunctional CD4+ T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate

Author

Graves, Shawna F., Kouriba, Bourema, Diarra, Issa, Daou, Modibo, Niangaly, Amadou, Coulibaly, Drissa, Keita, Yamoussa, Laurens, Matthew B., Berry, Andrea A., Vekemans, Johan, Ripley Ballou, W., Lanar, David E., Dutta, Sheetij, Gray Heppner, D., Soisson, Lorraine, Diggs, Carter L., Thera, Mahamadou A., Doumbo, Ogobara K., Plowe, Christopher V., Sztein, Marcelo B., and Lyke, Kirsten E.

Published
2016
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25. Hemoglobin C Trait Provides Protection From Clinical Falciparum Malaria in Malian Children

Author

Travassos, Mark A., Coulibaly, Drissa, Laurens, Matthew B., Dembélé, Ahmadou, Tolo, Youssouf, Koné, Abdoulaye K., Traoré, Karim, Niangaly, Amadou, Guindo, Aldiouma, Wu, Yukun, Berry, Andrea A., Jacob, Christopher G., Takala-Harrison, Shannon, Adams, Matthew, Shrestha, Biraj, Mu, Amy Z., Kouriba, Bourema, Lyke, Kirsten E., Diallo, Dapa A., Doumbo, Ogobara K., Plowe, Christopher V., and Thera, Mahamadou A.

Published
2015

26. A Novel Ex Vivo Drug Assay for Assessing the Transmission-Blocking Activity of Compounds on Field-Isolated Plasmodium falciparum Gametocytes

Author

Ouologuem, Dinkorma T., primary, Dembele, Laurent, additional, Dara, Antoine, additional, Kone, Aminatou K., additional, Diallo, Nouhoum, additional, Sangare, Cheick P. O., additional, Ballo, Fatoumata I., additional, Dao, François, additional, Goita, Siaka, additional, Haidara, Aboubecrin S., additional, Traore, Aliou, additional, Niangaly, Amadou B., additional, Dama, Souleymane, additional, Sissoko, Sekou, additional, Sogore, Fanta, additional, Dara, Jacob N., additional, Barre, Yacouba N., additional, Daou, Amadou, additional, Cisse, Fatoumata, additional, Diakite, Ousmaila, additional, Doumbia, Diagassan, additional, Koumare, Sekou, additional, Fofana, Bakary, additional, Tandina, Fatalmoudou, additional, Sylla, Daman, additional, Sacko, Adama, additional, Coulibaly, Mamadou, additional, Tekete, Mamadou M., additional, Ouattara, Amed, additional, and Djimde, Abdoulaye A., additional

Published
2022
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27. Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles

Author

Tebben, Kieran, primary, Yirampo, Salif, additional, Coulibaly, Drissa, additional, Koné, Abdoulaye K., additional, Laurens, Matthew B., additional, Stucke, Emily M., additional, Dembélé, Ahmadou, additional, Tolo, Youssouf, additional, Traoré, Karim, additional, Niangaly, Amadou, additional, Berry, Andrea A., additional, Kouriba, Bourema, additional, Plowe, Christopher V., additional, Doumbo, Ogobara K, additional, Lyke, Kirsten E., additional, Takala-Harrison, Shannon, additional, Thera, Mahamadou A., additional, Travassos, Mark A., additional, and Serre, David, additional

Published
2022
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28. Seroreactivity to Plasmodium falciparum Erythrocyte Membrane Protein 1 Intracellular Domain in Malaria-Exposed Children and Adults

Author

Travassos, Mark A., Niangaly, Amadou, Bailey, Jason A., Ouattara, Amed, Coulibaly, Drissa, Laurens, Matthew B., Pablo, Jozelyn, Jasinskas, Algis, Nakajima-Sasaki, Rie, Berry, Andrea A., Takala-Harrison, Shannon, Kouriba, Bourema, Rowe, J. Alexandra, Lyke, Kirsten E., Doumbo, Ogobara K., Thera, Mahamadou A., Felgner, Philip L., and Plowe, Christopher V.

Published
2013
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29. An In Silico Analysis of Malaria Pre-Erythrocytic-Stage Antigens Interpreting Worldwide Genetic Data to Suggest Vaccine Candidate Variants and Epitopes

Author

Ouattara, Amed, primary, Dwivedit, Anki, additional, Adams, Matthew, additional, Niangaly, Amadou, additional, Laurens, Matthew B., additional, Nyunt, Myaing M., additional, Plowe, Christopher V., additional, Djimde, Abdoulaye, additional, Takala-Harrison, Shannon, additional, and Silva, Joana C., additional

Published
2022
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31. Early Interferon-γ Response against Plasmodium falciparum Correlates with Interethnic Differences in Susceptibility to Parasitemia between Sympatric Fulani and Dogon in Mali

Author

McCall, Matthew B. B., Hopman, Joost, Daou, Madibo, Maiga, Boubacar, Dara, Victor, Ploemen, Ivo, Nganou-Makamdop, Krystelle, Niangaly, Amadou, Tolo, Youssouf, Arama, Charles, Bousema, J. Teun, van der Meer, Jos W., van der Ven, André J. A. M., Troye-Blomberg, Marita, Dolo, Amagana, Doumbo, Ogobara K., and Sauerwein, Robert W.

Published
2010

32. Successful Profiling of Plasmodium falciparum var Gene Expression in Clinical Samples via a Custom Capture Array

Author

Stucke, Emily M., primary, Dara, Antoine, additional, Dwivedi, Ankit, additional, Hodges, Theresa K., additional, Ott, Sandra, additional, Coulibaly, Drissa, additional, Koné, Abdoulaye K., additional, Traoré, Karim, additional, Guindo, Bouréima, additional, Tangara, Bourama M., additional, Niangaly, Amadou, additional, Daou, Modibo, additional, Diarra, Issa, additional, Tolo, Youssouf, additional, Sissoko, Mody, additional, Tallon, Luke J., additional, Sadzewicz, Lisa, additional, Zhou, Albert E., additional, Laurens, Matthew B., additional, Ouattara, Amed, additional, Kouriba, Bourema, additional, Doumbo, Ogobara K., additional, Takala-Harrison, Shannon, additional, Serre, David, additional, Plowe, Christopher V., additional, Thera, Mahamadou A., additional, Travassos, Mark A., additional, and Silva, Joana C., additional

Published
2021
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33. Ex Vivo Plasmodium malariae Culture Method for Antimalarial Drugs Screen in the Field

Author

Dembele, Laurent, primary, Diallo, Nouhoum, additional, Sogore, Fanta, additional, Diarra, Bintou, additional, Ballo, Fatoumata I., additional, Daou, Amadou, additional, Diakite, Ousmaila, additional, Bare, Yacouba, additional, Sangare, Cheick Papa Oumar, additional, Haidara, Aboubecrin Sedhigh, additional, Diakite, Seidina A. S., additional, Niangaly, Amadou, additional, Diakite, Mahamadou, additional, Campo, Brice, additional, Awandare, Gordon A., additional, Aniweh, Yaw, additional, and Djimde, Abdoulaye A., additional

Published
2021
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34. A Decline and Age Shift in Malaria Incidence in Rural Mali following Implementation of Seasonal Malaria Chemoprevention and Indoor Residual Spraying

Author

Coulibaly, Drissa, primary, Guindo, Boureima, additional, Niangaly, Amadou, additional, Maiga, Fayçal, additional, Konate, Salimata, additional, Kodio, Aly, additional, Diallo, Astou, additional, Antar, Abdou Tahirou Mohamed, additional, Kone, Abdoulaye K., additional, Traore, Karim, additional, Travassos, Mark A., additional, Sagara, Issaka, additional, Doumbo, Ogobara K., additional, and Thera, Mahamadou A., additional

Published
2021
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35. Spatio-temporal distribution of malaria one year after the implementation of additional preventive strategies in Bandiagara, Mali

Author

Coulibaly, Drissa, primary, Guindo, Boureima, additional, Maiga, Fayçal, additional, Konate, Salimata, additional, Diallo, Astou, additional, Antar, Abdou Tahirou Mohamed, additional, Niangaly, Amadou, additional, Kone, Abdoulaye Kassoum, additional, Traore, Karim, additional, Laurens, Matthew B, additional, Doumbo, Ogobara K, additional, and Thera, Mahamadou Ali, additional

Published
2020
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36. A Field Trial to Assess a Blood-Stage Malaria Vaccine

Author

Thera, Mahamadou A., Doumbo, Ogobara K., Coulibaly, Drissa, Laurens, Matthew B., Ouattara, Amed, Kone, Abdoulaye K., Guindo, Ando B., Traore, Karim, Traore, Idrissa, Kouriba, Bourema, Diallo, Dapa A., Diarra, Issa, Daou, Modibo, Dolo, Amagana, Tolo, Youssouf, Sissoko, Mahamadou S., Niangaly, Amadou, Sissoko, Mady, Takala-Harrison, Shannon, Lyke, Kirsten E., Wu, Yukun, Blackwelder, William C., Godeaux, Olivier, Vekemans, Johan, Dubois, Marie-Claude, Ballou, Ripley W., Cohen, Joe, Thompson, Darby, Dube, Tina, Soisson, Lorraine, Diggs, Carter L., House, Brent, Lanar, David E., Dutta, Sheetij, Heppner, Gray D., Jr, and Plowe, Christopher V.

Published
2011
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37. Host and Parasite Transcriptomic Changes upon Successive Plasmodium falciparum Infections in Early Childhood

Author

Bradwell, Katie R., primary, Coulibaly, Drissa, additional, Koné, Abdoulaye K., additional, Laurens, Matthew B., additional, Dembélé, Ahmadou, additional, Tolo, Youssouf, additional, Traoré, Karim, additional, Niangaly, Amadou, additional, Berry, Andrea A., additional, Kouriba, Bourema, additional, Plowe, Christopher V., additional, Doumbo, Ogobara K., additional, Lyke, Kirsten E., additional, Takala-Harrison, Shannon, additional, Thera, Mahamadou A., additional, Travassos, Mark A., additional, and Serre, David, additional

Published
2020
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38. Epitope-based sieve analysis of Plasmodium falciparum sequences from a FMP2.1/AS02A vaccine trial is consistent with differential vaccine efficacy against immunologically relevant AMA1 variants

Author

Ouattara, Amed, primary, Niangaly, Amadou, additional, Adams, Matthew, additional, Coulibaly, Drissa, additional, Kone, Abdoulaye K., additional, Traore, Karim, additional, Laurens, Matthew B., additional, Tolo, Youssouf, additional, Kouriba, Bourema, additional, Diallo, Dapa A., additional, Doumbo, Ogobara K., additional, Plowe, Christopher V., additional, Djimdé, Abdoulaye, additional, Thera, Mahamadou A., additional, Laufer, Miriam K., additional, Takala-Harrison, Shannon, additional, and Silva, Joana C., additional

Published
2020
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39. A decline and age shift in malaria incidence in rural Mali following implementation of seasonal malaria chemoprevention and indoor residual spraying

Author

Coulibaly, Drissa, primary, Guindo, Boureima, additional, Niangaly, Amadou, additional, Maiga, Fayçal, additional, Konate, Salimata, additional, Kodio, Aly, additional, Diallo, Astou, additional, Antar, Abdou Tahirou Mohamed, additional, Kone, Abdoulaye K, additional, Traore, Karim, additional, Travassos, Mark, additional, Doumbo, Ogobara K, additional, and Thera, Mahamadou A, additional

Published
2020
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40. PS-003: EVIDENCE-INFORMED POLICY MAKING: CHALLENGES AND OPPORTUNITIES

Author

Makanga, Michael, Beattie, Pauline, Breugelmans, Gabrielle, Nyirenda, Thomas, Bockarie, Moses, Tanner, Marcel, Volmink, Jimmy, Hankins, Catherine, Walzl, Gerhard, Chegou, Novel, Malherbe, Stephanus, Hatherill, Mark, Scriba, Thomas J., Zak, Daniel E., Barry, Clifton E., Kaufmann, Stefan H.E., Noor, Abdisalan, Strub-Wourgaft, Nathalie, Phillips, Patrick, Munguambe, Khátia, Ravinetto, Raffaella, Tinto, Halidou, Diro, Ermias, Mahendrahata, Yodi, Okebe, Joseph, Rijal, Suman, Garcia, Coralith, Sundar, Shyam, Ndayisaba, Gilles, Sopheak, Thai, Ngoduc, Thang, Loen, Harry Van, Jacobs, Jan, D'Alessandro, Umberto, Boelaert, Marleen, Buvé, Anne, Kamalo, Patrick, Manda-Taylor, Lucinda, Rennie, Stuart, Mokgatla, Boitumelo, Bahati, Prince, Ijsselmuiden, Carel, Afolabi, Muhammed, Mcgrath, Nuala, Kampmann, Beate, Imoukhuede, Egeruan, Alexander, Neal, Larson, Heidi, Chandramohan, Daniel, Bojang, Kalifa, Kasaro, Margaret Phiri, Muluka, Brenda, Kaunda, Kaunda, Morse, Jill, Westfall, Andrew, Kapata, Nathan, Kruuner, Annika, Henostroza, German, Reid, Stewart, Alabi, Abraham, Foguim, Francis, Sankarganesh, Jeyaraj, Bruske, Ellen, Mfoumbi, Arnault, Mevyann, Chester, Adegnika, Ayola, Lell, Bertrand, Kranzer, Katharina, Kremsner, Peter, Grobusch, Martin, Sabiiti, Wilber, Ntinginya, Nyanda, Kuchaka, Davis, Azam, Khalide, Kampira, Elizabeth, Mtafya, Bariki, Bowness, Ruth, Bhatt, Nilesh, Davies, Gerry, Kibiki, Gibson, Gillespie, Stephen, Lejon, Veerle, Ilboudo, Hamidou, Mumba, Dieudonné, Camara, Mamady, Kaba, Dramane, Lumbala, Crispin, Fèvre, Eric, Jamonneau, Vincent, Bucheton, Bruno, Büscher, Philippe, Chisenga, Caroline, Sinkala, Edford, Chilengi, Roma, Chitundu, Hellen, Zyambo, Zude, Wandeler, Gilles, Vinikoor, Michael, Emilie, Dama, Camara, Oumou, Mathurin, Koffi, Guiguigbaza-Kossigan, Dayo, Philippe, Büscher, Regassa, Fikru, Hassane, Sakande, Bienvenu, Somda Martin, Fabrice, Courtin, Ouédraogo, Elie, Kouakou, Lingue, Owusu, Michael, Mensah, Eric, Enimil, Anthony, Mutocheluh, Mohamed, Ndongo, Francis Ateba, Tejiokem, Mathurin Cyrille, Texier, Gaetan, Penda, Calixte, Ndiang, Suzie, Ndongo, Jean-Audrey, Guemkam, Georgette, Sofeu, Casimir Ledoux, Afumbom, Kfutwa, Faye, Albert, Msellati, Philippe, Warszawski, Josiane, Vos, Alinda, Devillé, Walter, Barth, Roos, Klipstein-Grobusch, Kerstin, Tempelman, Hugo, Venter, François, Coutinho, Roel, Grobbee, Diederick, Ssemwanga, Deogratius, Lyagoba, Frederick, Magambo, Brian, Kapaata, Anne, Kirangwa, Joseph, Nannyonjo, Maria, Nassolo, Faridah, Nsubuga, Rebecca, Yebra, Gonzalo, Brown, Andrew, Kaleebu, Pontiano, Nylén, Hanna, Habtewold, Abiy, Makonnen, Eyasu, Yimer, Getnet, Burhenne, Jürgen, Diczfalusy, Ulf, Aklillu, Eleni, Steele, Duncan, Walker, Richard, Simuyandi, Michelo, Beres, Laura, Bosomprah, Samuel, Ansumana, Rashid, Taitt, C., Lamin, J.M., Jacobsen, K.H., Mulvaney, S.P., Leski, T., Bangura, U., Stenger, D., Vries, Sophie De, Zinsou, Frejus Jeannot, Honkpehedji, J, Dejon, Jean Claude, Loembe, Marguerite Massinga, Bache, Bache, Pakker, Nadine, Leeuwen, Remko Van, Hounkpatin, Aurore Bouyoukou, Yazdanbakhsh, Maria, Bethony, Jeffrey, Hotez, Peter, Diemert, David, Bache, Bache Emmanuel, Fernandes, José F., Mba, Régis M Obiang, Kabwende, Anita L., Grobusch, Martin P., Krishna, Sanjeev, Kremsner, Peter G., Todagbe, Agnandji Selidji, Nambozi, Michael, Kabuya, Jean-Bertin, Hachizovu, Sebastian, Mwakazanga, David, Kasongo, Webster, Buyze, Jozefien, Mulenga, Modest, Geertruyden, Jean-Pierre, Gitaka, Jesse, Chan, Chim, Kongere, James, Kagaya, Wataru, Kaneko, Akira, Kabore, Naomie, Barry, Nouhoun, Kabre, Zachari, Werme, Karidia, Fofana, Aminata, Compaore, Daniel, Nikiema, Frederic, Some, Fabrice, Djimde, Abdoulaye, Zongo, Issaka, Ouedraogo, Bosco, Kone, Aminatou, Sagara, Issaka, Björkman, Anders, Gil, Jose Pedro, Nchinda, Godwin, Bopda, Alain, Nji, Nadesh, Ambada, Georgia, Ngu, Loveline, Tchadji, Jules, Sake, Carol, Magagoum, Suzanne, Njambe, Ghislain D., Lisom, Abel, Park, Chae Gyu, Tait, Dereck, Sibusiso, Hlatjwako, Manda, Olga, Croucher, Kristin, Westhuizen, Anja Van Der, Mshanga, Isaac, Levin, Jonathan, Nanvubya, Annet, Kibengo, Freddie, Jaoko, Walter, Pala, Pietro, Perreau, Matthieu, Namuniina, Annemarie, Kitandwe, Paul, Tapia, Gonzalo, Serwanga, Jennifer, Yates, Nicole, Fast, Pat, Mayer, Bryan, Montefiori, David, Tomaras, Georgia, Robb, Merlin, Lee, Carter, Wagner, Ralf, Sanders, Edward, Kilembe, William, Kiwanuka, Noah, Gilmour, Jill, Kuipers, Hester, Vooij, Dani, Chinyenze, Kundai, Priddy, Frances, Ding, Song, Hanke, Tom, Pantaleo, Giuseppe, Ngasala, Billy, Jovel, Irina, Malmberg, Maja, Mmbando, Bruno, Premji, Zul, Mårtensson, Andreas, Mwaiswelo, Richard, Agbor, Lenshina, Apinjoh, Tobias, Mwanza, Sydney, Chileshe, Justin, Joshi, Sudhaunshu, Malunga, Phidelis, Manyando, Christine, Laufer, Miriam, Dara, Antoine, Niangaly, Amadou, Sinha, Indranil, Brodin, David, Fofana, Bakary, Dama, Souleymane, Dembele, Demba, Sidibe, Bakary, Diallo, Nouhoum, Thera, Mahamadou, Wright, Karin, Gil, Jose, Doumbo, Ogobara, Baraka, Vito, Nabasumba, Carolyn, Francis, Filbert, Lutumba, Pascal, Mavoko, Hypolite, Alifrangis, Michael, Geertruyden, Jean-Pierre Van, Sissoko, Sekou, Sangaré, Cheick, Toure, Sekou, Sanogo, Kassim, Diakite, Hamadoun, Toure, Siaka, Doumbia, Diagassan, Haidara, Kadiatou, Julé, Amélie, Ashurst, Hazel, Merson, Laura, Olliaro, Piero, Marsh, Vicki, Lang, Trudie, Guérin, Philippe, Awuondo, Kennedy, Njenga, Daniel, Nyakarungu, Elizabeth, Titus, Pauline, Sutamihardja, Awalludin, Lowe, Brett, Ogutu, Bernhards, Billingsley, Peter, Soulama, Issiaka, Kaboré, Moïse, Coulibaly, Aboubacar, Ouattara, Maurice, Sanon, Souleymane, Diarra, Amidou, Bougouma, Edith, Ouedraogo, Alphonse, Sombie, Benjamin, Ouedraogo, Amidou, Kargougou, Désiré, Ouattara, Daouda, Issa, Nebie, Tiono, Alfred, Sirima, Sodiomon, Chaponda, Mike, Dabira, Edgard, Dao, François, Dara, Nianwalou, Sidibe, Bouran, Coulibaly, Moctar, Tolo, Allaye, Maiga, Hamma, Ouologuem, Nouhoum, Niangaly, Hamidou, Botchway, Felix, Wilson, Nana, Dickinson-Copeland, Carmen M, Adjei, Andrew A., Wilson, Michael, Stiles, Jonathan K., Hamid, Muzamil Abdel, Awad-Elgeid, Mona, Nasr, Awad, Netongo, Palmer, Kamdem, Séverin, Velavan, Thirumalaisamy, Lasry, Estrella, Diarra, Modibo, Bamadio, Amadou, Traore, Aliou, Coumare, Samba, Soma, Bahonan, Dicko, Yeyia, Sangare, Boubou, Tembely, Aly, Traore, Djibril, Haidara, Aboubecrin, Dicko, Alassane, Diawara, Elisabeth, Beavogui, Abdoul, Camara, Daouda, Sylla, Malick, Yattara, Mohamed, Sow, Amadou, Camara, Gnèpou Camara, Diallo, Saliou, Mombo-Ngoma, Ghyslain, Remppis, Jonathan, Sievers, Moritz, Manego, Rella Zoleko, Endamne, Lilian, Hutchinson, David, Held, Jana, Supan, Christian, Salazar, Carmen L. Ospina, Bonkian, Léa Nadège, Nahum, Alain, Sié, Ali, Abdulla, Salim, Cantalloube, Cathy, Djeriou, Elhadj, Bouyou-Akotet, Marielle, Mordmüller, Benjamin, Siribie, Mohamadou, Sirima, Sodiomon B., Ouattara, San Maurice, Coulibaly, Sam, Kabore, Jean Moïse, Amidou, Diarra, Tekete, Mamadou, Burhenne, Juergen, Traore, Oumar, Haefeli, Walter, Borrmann, Steffen, Kaboré, Naomie, Kabré, Zachari, Nikèma, Fréderic, Compaoré, Daniel, Somé, Fabrice, Djimdé, Abdoulaye, Ouédraogo, Jean, Chalwe, Victor, Miller, John, Diakité, Hamadoun, Greco, Beatrice, Spangenberg, Thomas, Kourany-Lefoll, Elly, Oeuvray, Claude, Mulry, Jim, Tyagarajan, Kamala, Magsaam, Bettina, Barnes, Karen, Hodel, Eva Maria, Humphreys, Georgina, Pace, Cheryl, Banda, C.G, Denti, Paulo, Allen, Elizabeth, Lalloo, David, Mwapasa, Victor, Terlouw, Anja, Mwesigwa, Julia, Achan, Jane, Jawara, Musa, Ditanna, Gian, Worwui, Archibald, Affara, Muna, Koukouikila-Koussounda, Félix, Kombo, Michael, Vouvoungui, Christevy, Ntoumi, Francine, Etoka-Beka, Mandingha Kosso, Deibert, Julia, Poulain, Pierre, Kobawila, Simon, Gueye, Nerly Gampio, Koukouikila-Koussounda, Felix, Seda, Brian, Kwambai, Titus, Jangu, Phelix, Samuels, Aaron, ter Kuile, Feike, Kariuki, Simon, Barry, Aissata, Bousema, Teun, Okech, Brenda, Egwang, Thomas, Corran, Patrick, Riley, Eleanor, Ezennia, Ifeoma, Ekwunife, Obinna, Muleba, Mbanga, Stevenson, Jennifer, Mbata, Keith, Coetzee, Maureen, Norris, Douglas, Moneke-Anyanwoke, Ngozi, Momodou, Jasseh, Clarke, Ed, Scott, Susana, Tijani, Adelani, Djimde, Moussa, Vaillant, Michel, Samouda, Hanen, Mensah, Victorine, Roetynck, Sophie, Kanteh, Ebrima, Bowyer, Georgina, Ndaw, Amy, Oko, Francis, Bliss, Carly, Jagne, Ya Jankey, Cortese, Riccardo, Nicosia, Alfredo, Roberts, Rachel, D'Alessio, Flavia, Leroy, Odile, Faye, Babacar, Cisse, Badara, Gerry, Stephen, Viebig, Nicola, Lawrie, Alison, Ewer, Katie, Hill, Adrian, Nebie, Issa, Tiono, Alfred B, Sanou, Guillaume, Konate, Amadou T, Yaro, Baptiste J, Sodiomon, Sirima, Honkpehedji, Yabo, Agobe, Jean Claude Dejon, Zinsou, Frejus, Mengue, Juliana, Richie, Thomas, Hoffman, Stephen, Nouatin, Odilon, Ngoa, Ulysse Ateba, Edoa, Jean R, Homoet, Andreas, Engelhon, Julie Englhon, Massinga-Louembe, Marguerite, Esen, Meral, Theisen, Michael, Sim, Kim Lee, Luty, Adrian Jf, Moutairou, Kabirou, Dinko, Bismarck, King, Elizabeth, Targett, Geoffrey, Sutherland, Colin, Likhovole, Clement, Ouma, Collins, Vulule, John, Musau, Susan, Khayumbi, Jeremiah, Okumu, Albert, Murithi, Wilfred, Otu, Jacob, Gehre, Florian, Zingue, Dezemon, Kudzawu, Samuel, Forson, Audrey, Mane, Morto, Rabna, Paulo, Diarra, Bassirou, Kayede, Salako, Adebiyi, Emmanuel, Kehinde, Aderemi, Onyejepu, Nneka, Onubogu, Catherine, Idigbe, Emmanuel, Ba, Awa, Diallo, Aissatou, Mboup, Souleymane, Disse, Kodjo, Kadanga, Gerard, Dagnra, Yaotse, Baldeh, Ignatius, Corrah, Tumani, Jong, Bouke De, Antonio, Martin, Musanabaganwa, Clarisse, Musabyimana, Jean Pierre, Karita, Etienne, Diop, Blondin, Nambajimana, Abidan, Dushimiyimana, Valentine, Karame, Prosper, Russell, Jim, Ndoli, Jules, Hategekimana, Theobald, Sendegeya, Augustin, Condo, Jeannine, Binagwaho, Agnes, Okonko, Iheanyi, Okerentugba, Phillip, Opaleye, Oluyinka, Awujo, Ezinwanne, Frank-Peterside, Nnenna, Moyo, Sikhulile, Kotokwe, Kenanao, Mohammed, Terence, Boleo, Coretah, Mupfumi, Lucy, Chishala, Samuel, Gaseitsiwe, Simani, Tsalaile, Lesedi, Bussmann, Herman, Makhema, Joseph, Baum, Marianna, Marlink, Richard, Engelbretch, Susan, Essex, Max, Novitsky, Vladimir, Saka, Emmanuel, Kalipalire, Zex, Bhairavabhotla, Ravikiran, Midiani, Dalitso, Sherman, Judith, Mgode, Georgies, Cox, Christophe, Bwana, Dickens, Mtui, Leah, Magesa, Daniel, Kahwa, Amos, Mfinanga, Godfrey, Mulder, Christiaan, Borain, Nick, Petersen, Lizette, Plessis, Julianne Du, Theron, Grant, Holm-Hansen, Carol, Tekwu, Emmanuel Mouafo, Sidze, Larissa Kamgue, Assam, Jean Paul Assam, Eyangoh, Sarah, Niemann, Stefan, Beng, Veronique Penlap, Frank, Matthias, Atiadeve, Samuel, Hilmann, Doris, Awoniyi, Dolapo, Baumann, Ralf, Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre, Kaempfer, Susanne, Singh, Mahavir, Mwanza, Winnie, Milimo, Deborah, Moyo, Maureen, Kasese, Nkatya, Cheeba-Lengwe, Maina, Munkondya, Stembiso, Ayles, Helen, Haas, Petra De, Muyoyeta, Monde, Namuganga, Anna Ritah, Kizza, Harriet Mayanja, Mendy, Alieu, Tientcheu, Leopold, Ayorinde, Abigail, Coker, Edward, Egere, Uzochukwu, Coussens, Anna, Naude, Celeste, Chaplin, George, Noursadeghi, Mahdad, Martineau, Adrian, Jablonski, Nina, Wilkinson, Robert, Ouedraogo, Henri Gautier, Matteelli, Alberto, Regazzi, Mario, Tarnagda, Grissoum, Villani, Paola, Sulis, Giorgia, Diagbouga, Serge, Roggi, Alberto, Giorgetti, Francesco, Kouanda, Seni, Bidias, Amel, Ndjonka, Dieudonné, Olemba, Clémence, Souleymanou, Arabo, Mukonzo, Jackson, Kuteesa, Ronald, Ogwal-Okeng, Jasper, Gustafsson, Lars L., Owen, Joel, Bassi, Peter, Gashau, Wadzani, Olaf, Klungel, Dodoo, Alexander, Okonkwo, Prosper, Kanki, Phyllis, Maruapula, Dorcas, Seraise, Boitumelo, Einkauf, Kevin, Reilly, Amanda, Rowley, Christopher, Musonda, Rosemary, Framhein, Anna, Mpagama, Stella, Semvua, Hadija, Maboko, Leonard, Hoelscher, Michael, Heinrich, Norbert, Mulenga, Lloyd, Kaayunga, Callistus, Davies, Mary-Ann, Egger, Matthias, Musukuma, Kalo, Dambe, Rosalia, Usadi, Benjamin, Ngari, Moses, Thitiri, Johnstone, Mwalekwa, Laura, Fegan, Greg, Berkley, James, Nsagha, Dickson, Munamunungu, Virginia, Bolton, Carolyn, Siyunda, Alice, Shilimi, Jacinta, Bucciardini, Raffaella, Fragola, Vincenzo, Abegaz, Teshome, Lucattini, Stefano, Halifom, Atakilt, Tadesse, Eskedar, Berhe, Micheal, Pugliese, Katherina, Castro, Paola De, Terlizzi, Roberta, Fucili, Luca, Gregorio, Massimiliano Di, Mirra, Marco, Zegeye, Teame, Binelli, Andrea, Vella, Stefano, Abraham, Loko, Godefay, Hagos, Rakotoarivelo, Rivo, Raberahona, Mihaja, Randriamampionona, Njary, Andriamihaja, Rabezanahary, Rasamoelina, Tahinamandranto, Cornet, Muriel, Randria, Mamy Jean De Dieu, Benet, Thomas, Vanhems, Philippe, Andrianarivelo, Mala Rakoto, Chirwa, Uchizi, Michelo, Charles, Hamoonga, Raymond, Wandiga, Steve, Oduor, Patience, Agaya, Janet, Sharma, Aditya, Cavanaugh, Sean, Cain, Kevin, Mukisa, John, Mupere, Ezekiel, Worodria, William, Ngom, Justice Trésor, Koro, Francioli, Godwe, Celestin, Adande, Clemence, Ateugieu, Romaric, Onana, Tatiana, Ngono, Annie, Kamdem, Yannick, Ngo-Niobe, Sara, Etoa, François-Xavier, Kanengoni, Muchineripi, Ruzario, Sithembile, Ndebele, Paul, Shana, Melody, Tarumbiswa, Fadzai, Musesengwa, Rosemary, Gutsire, Rutendo, Fisher, Kevin, Thyagarajan, Bargavi, Akanbi, Olusola, Binuyo, Michael, Ssengooba, Willy, Respeito, Durval, Mambuque, Edson, Blanco, Silvia, Mandomando, Inacio, Cobelens, Frank, Garcia-Basteiro, Alberto, Tamene, Ayele, Topp, Stephanie, Mwamba, Chanda, Padian, Nancy, Sikazwe, Izukanji, Geng, Elvin, Holmes, Charles, Sikombe, Kombatende, Hantuba, Cardinal, Czaicki, Nancy, Simbeza, Sandra, Somwe, Paul, Umulisa, Michele, Ilo, Jennifer, Kestelyn, Evelyne, Uwineza, Mireille, Agaba, Stephen, Delvaux, Therese, Wijgert, Janneke, Gethi, Dickson, Odeny, Lazarus, Tamandjou, Cynthia, Kaindjee-Tjituka, Francina, Brandt, Laura, Cotton, Mark, Nel, Etienne, Preiser, Wolfgang, Andersson, Monique, Adepoju, Abiola, Magana, Musa, Etsetowaghan, Andrew, Chilikwazi, Mutinta, Sutcliffe, Catherine, Thuma, Philip, Sinywimaanzi, Kathy, Matakala, Hellen, Munachoonga, Passwell, Moss, William, Masenza, Issa Sabi, Geisenberger, Otto, Agrea, Peter, Rwegoshora, France, Mahiga, Hellen, Olomi, Willyhelmina, Kroidl, Arne, Kayode, Gbenga, Amoakoh-Coleman, Mary, Ansah, Evelyn, Uthman, Olalekan, Fokam, Joseph, Santoro, Maria-Mercedes, Musolo, Chrissie, Chimbiri, Isabel, Chikwenga, Gloria, Deula, Ruth, Massari, Riccardo, Lungu, Agness, Perno, Carlo-Federico, Ndzengue, Georgia, Loveline, Ngu, Lissom, Abel, Flaurent, Tchouangueu, Sosso, Samuel, Essomba, Claudine, Kpeli, Grace, Otchere, Isaac, Lamelas, Araceli, Buultjens, Andrew, Bulach, Dieter, Baines, Sarah, Seemann, Torsten, Giulieri, Stefano, Nakobu, Zuliehatu, Aboagye, Samuel, Owusu-Mireku, Evelyn, Danso, Emelia, Hauser, Julia, Hinic, Vladimira, Pluschke, Gerd, Stinear, Timothy, Yeboah-Manu, Dorothy, Elshayeb, Ayman, Siddig, Marmar El, Ahmed, Abdel Azim, Hussien, Adil El, Kabwe, Mwila, Tembo, John, Chilukutu, Lophina, Chilufya, Moses, Ngulube, Francis, Lukwesa, Chileshe, Enne, Virve, Wexner, Hannah, Mwananyanda, Lawrence, Hamer, Davidson, Sinyangwe, Sylvester, Ahmed, Yusuf, Klein, Nigel, Maeurer, Markus, Zumla, Ali, Bates, Matthew, Beyala, Landry, Etienne, Guenou, Anthony, Njimbia, Benjamin, Azike, Ateudjieu, Jerome, Chibwe, Bertha, Ojok, David, Tarr, Christine Attia, Perez, Guillermo Martinez, Omeonga, Senga, Kibungu, Fanta, Meyer, Ana, Lansana, Peter, Mayor, Alfredo, Onyango, Peter, Loggerenberg, François Van, Furtado, Tamzin, Boggs, Liam, Segrt, Alexis, Dochez, Carine, Burnett, Rosemary, Mphahlele, M. Jeffrey, Miiro, George, Mbidde, Edward, Peshu, Norbert, Kivaya, Esther, Ngowi, Bernard, Kavishe, Reginald, Maowia, Mukhtar, Sandstrom, Eric, Ayuo, Elizabeth, Mmbaga, Blandina, Leisegang, Cordelia, Thorpe, Marie, Batchilly, Elizabeth, N'Guessan, Jean-Pierre, Kanteh, Dembo, Søfteland, Solrun, Sebitloane, Motshedisi, Vwalika, Bellington, Taylor, Myra, Galappaththi-Arachchige, Hashini, Holmen, Sigve, Gundersen, Svein Gunnar, Ndhlovu, Patricia, Kjetland, Eyrun Floerecke, Kombe, Francis, Toohey, Jacintha, Pienaar, Elizabeth, Kredo, Tamara, Cham, Pa Modou, Abubakar, Ismaela, Dondeh, Bai Lamin, Vischer, Nerina, Pfeiffer, Constanze, Burri, Christian, Musukwa, Kalo, Zürcher, Samuel, Mwandu, Temwani, Bauer, Sophie, Adriko, Moses, Mwaura, Peter, Omolloh, Kevin, Jones, Clarer, Malecela, Mwelecele, Hamidu, Buhari Adamu, Jenner, Tettevi Edward, Asiedu, Larbi John, Osei-Atweneboana, Mike, Afeke, Innocent, Addo, Phyllis, Newman, Mercy, Durnez, Lies, Eddyani, Miriam, Ammisah, Nana, Abas, Mona, Quartey, Maxwell, Ablordey, Anthony, Akinwale, Olaoluwa, Adeneye, Adeniyi, Ezeugwu, Sylvanus, Olukosi, Yetunde, Adewale, Babatunde, Sulyman, Medinat, Mafe, Margaret, Okwuzu, Jane, Gyang, Pam, Nwafor, Timothy, Henry, Uzoma, Musa, Bilkisu, Ujah, Innocent, Agobé, Jean Claude Dejon, Grau-Pujol, Berta, Sacoor, Charfudin, Nhabomba, Augusto, Casellas, Aina, Quintó, Llorenç, Subirà, Carme, Giné, Ricard, Valentín, Antònia, Muñoz, Jose, Nikiema, Marguerite, Ky-Ba, Absatou, Comapore, Kiswendsida Abdou Muller, Traore, Alfred, Sangare, Lassana, Oluremi, Adeolu, Michel, Mandro, Camara, Yaya, Sanneh, Bakary, Cuamba, Inocencia, Gutiérrez, Jose, Lázaro, Carlota, Mejia, Rojelio, Adedeji, Abimbola, Folorunsho, Sola, Demehin, Pelumi, Akinsanya, Bamidele, Cowley, Giovanna, Silva, Eunice Teixeira Da, Nabicassa, Meno, Barros, Pedrozinho Duarte Pereira De, Blif, Milena Mbote, Bailey, Robin, Last, Anna, Mahendradhata, Yodi, Gotuzzo, Eduardo, Nys, Kateljine De, Casteels, Minnes, Nona, Sylvie Kwedi, Lumeka, Kabwende, Todagbe, Agnandji, Djima, Mariam Mama, Ukpong, Morenike, Sagay, Atiene, Khamofu, Hadiza, Torpey, Kwasi, Afiadigwe, Evaristus, Anenih, James, Ezechi, Oliver, Nweneka, Chidi, Idoko, John, Muhumuza, Simon, Katahoire, Anne, Nuwaha, Fred, Olsen, Annette, Okeyo, Seth, Omollo, Raymond, Kimutai, Robert, Ochieng, Michael, Egondi, Thaddaeus, Moonga, Clement, Chileshe, Chisele, Magwende, George, Anumudu, Chiaka, Onile, Olugbenga, Oladele, Victoria, Adebayo, Adewale, Awobode, Henrietta, Oyeyemi, Oyetunde, Odaibo, Alexander, Kabuye, Emily, Lutalo, Tom, Njua-Yafi, Clarisse, Nkuo-Akenji, Theresa, Anchang-Kimbi, Judith, Mugri, Regina, Chi, Hanesh, Tata, Rolland, Njumkeng, Charles, Dodoo, Daniel, Achidi, Eric, Fernandes, José, Bache, Emmanuel B., Matakala, Kalumbu, Searle, Kelly, Greenman, Michelle, and Rainwater-Lovett, Kaitlin

Subjects
Abstracts of Poster Presentations, Abstracts of Oral Presentations, Author Index, Abstracts of Presentations in Plenary Sessions, Article, Abstracts of the Eighth Edctp Forum, 6–9 November 2016
Published
2017

41. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Ndila, Carolyne M, Uyoga, Sophie, Macharia, Alexander W, Nyutu, Gideon, Peshu, Norbert, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Sepúlveda, Nuno, Clark, Taane G, Band, Gavin, Clarke, Geraldine, Rowlands, Kate, Hubbart, Christina, Jeffreys, Anna, Kariuki, Silvia, Marsh, Kevin, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, Williams, Thomas N, Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, Devries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Si, Le, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Alioune, Ly, Macharia, Alexander, Macinnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, Mccreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, Sanjoaquin, Miguel, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford, London School of Hygiene and Tropical Medicine (LSHTM), The Wellcome Trust Sanger Institute [Cambridge], St Mary's Hospital, Imperial College, TNW and MM are funded through awards from the Wellcome Trust (grants 091758 and 202800 [to TNW] and grant 088634 [to MM]) and DPK and TGC receive support from the Medical Research Council (grant G19/9 [to DPK] and grants MR/K000551/1, MR/M01360X/1, MR/N010469/1, and MC_PC_15103 [to TGC]). The research leading to these results received funding from the European Community's Seventh Framework Programme (FP7/2007-2013, under grant agreement 242095) and from the Medical Research Council (grant G0600718). MalariaGEN is supported by the Wellcome Trust (WT077383/Z/05/Z) and by the Foundation for the National Institutes of Health (grant 566) as part of the Bill & Melinda Gates' Grand Challenges in Global Health Initiative. The Resource Centre for Genomic Epidemiology of Malaria is supported by the Wellcome Trust (grant 090770/Z/09/Z). Support was also provided by the Medical Research Council (grant G0600718). The Wellcome Trust also provides core awards to the Wellcome Trust Centre for Human Genetics (grant 090532/Z/09/Z) and to the Wellcome Trust Sanger Institute (grant 098051). This work forms part of a larger collaboration with the MalariaGEN Consortium, whose members are listed at http://www.malariagen.net/projects/host/consortium-members. This paper is published with permission from the Director of the Kenya Medical Research Institute (KEMRI)., MalariaGEN Consortium (Anavaj Sakuntabhai), and European Project: 242095,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,EVIMALAR(2009)

Subjects
Case-Control Studies, Child, Child, Preschool, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Kenya, Malaria, Male, Polymorphism, Genetic, Hematology, macromolecular substances, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Article, Genetic, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, parasitic diseases, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Polymorphism, Preschool
Abstract

Summary Background Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress. Methods We did a case-control study in Kilifi County, Kenya. We recruited as cases children presenting with severe malaria to the high-dependency ward of Kilifi County Hospital. We included as controls infants born in the local community between Aug 1, 2006, and Sept 30, 2010, who were part of a genetics study. We tested for associations between a range of candidate malaria-protective genes and risk for severe malaria and its specific phenotypes. We used a permutation approach to account for multiple comparisons between polymorphisms and severe malaria. We judged p values less than 0·005 significant for the primary analysis of the association between candidate genes and severe malaria. Findings Between June 11, 1995, and June 12, 2008, 2244 children with severe malaria were recruited to the study, and 3949 infants were included as controls. Overall, 263 (12%) of 2244 children with severe malaria died in hospital, including 196 (16%) of 1233 with cerebral malaria. We investigated 121 polymorphisms in 70 candidate severe malaria-associated genes. We found significant associations between risk for severe malaria overall and polymorphisms in 15 genes or locations, of which most were related to red blood cells: ABO, ATP2B4, ARL14, CD40LG, FREM3, INPP4B, G6PD, HBA (both HBA1 and HBA2), HBB, IL10, LPHN2 (also known as ADGRL2), LOC727982, RPS6KL1, CAND1, and GNAS. Combined, these genetic associations accounted for 5·2% of the variance in risk for developing severe malaria among individuals in the general population. We confirmed established associations between severe malaria and sickle-cell trait (odds ratio [OR] 0·15, 95% CI 0·11–0·20; p=2·61 × 10−58), blood group O (0·74, 0·66–0·82; p=6·26 × 10−8), and –α3·7-thalassaemia (0·83, 0·76–0·90; p=2·06 × 10−6). We also found strong associations between overall risk of severe malaria and polymorphisms in both ATP2B4 (OR 0·76, 95% CI 0·63–0·92; p=0·001) and FREM3 (0·64, 0·53–0·79; p=3·18 × 10−14). The association with FREM3 could be accounted for by linkage disequilibrium with a complex structural mutation within the glycophorin gene region (comprising GYPA, GYPB, and GYPE) that encodes for the rare Dantu blood group antigen. Heterozygosity for Dantu was associated with risk for severe malaria (OR 0·57, 95% CI 0·49–0·68; p=3·22 × 10−11), as was homozygosity (0·26, 0·11–0·62; p=0·002). Interpretation Both ATP2B4 and the Dantu blood group antigen are associated with the structure and function of red blood cells. ATP2B4 codes for plasma membrane calcium-transporting ATPase 4 (the major calcium pump on red blood cells) and the glycophorins are ligands for parasites to invade red blood cells. Future work should aim at uncovering the mechanisms by which these polymorphisms can result in severe malaria protection and investigate the implications of these associations for wider health. Funding Wellcome Trust, UK Medical Research Council, European Union, and Foundation for the National Institutes of Health as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative.

Published
2018

42. Genetic polymorphisms with erythrocyte traits in malaria endemic areas of Mali

Author

Traore, Karim, primary, Konate, Salimata, additional, Thera, Mahamadou A., additional, Niangaly, Amadou, additional, Ba, Alhassane, additional, Niare, Alassane, additional, Arama, Charles, additional, Di Cristofaro, Julie, additional, Baby, Mounirou, additional, Picot, Stephane, additional, Chiaroni, Jacques, additional, Boetsch, Gilles, additional, and Doumbo, Ogobara K., additional

Published
2019
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43. Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali

Author

Ouattara Amed, Doumbo Safiatou, Saye Renion, Beavogui Abdoul H, Traoré Boubacar, Djimdé Abdoulaye, Niangaly Amadou, Kayentao Kassoum, Diallo Mouctar, Doumbo Ogobara K, and Thera Mahamadou A

Subjects
malaria, diagnostic, drug efficacy follow-up, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Malaria is a major public health problem in Mali and diagnosis is typically based on microscopy. Microscopy requires a well trained technician, a reliable power source, a functioning microscope and adequate supplies. The scarcity of resources of community health centres (CHC) does not allow for such a significant investment in only one aspect of malaria control. In this context, Rapid Diagnostic Tests (RDTs) may improve case management particularly in remote areas. Methods This multicentre study included 725 patients simultaneously screened with OptiMal-IT test and thick smears for malaria parasite detection. While evaluating the therapeutic efficacy of choroquine in 2 study sites, we compared the diagnostic values of thick smear microscopy to OptiMal-IT test applying the WHO 14 days follow-up scheme using samples collected from 344 patients. Results The sensitivity and the specificity of OptiMal-IT compared to thick smear was 97.2% and 95.4%, whereas the positive and negative predictive values were 96.7 and 96.1%, respectively. The percent agreement between the two diagnostic tests was 0.93. The two tests were comparable in detecting malaria at day 0, day 3 and day 14. The only difference was observed at day 7 due to high gametocytemia. Subjectively, health care providers found OptiMal-IT easier to use and store under field conditions. Conclusion OptiMal-IT test revealed similar results when compared to microscopy which is considered the gold standard for malaria diagnostics. The test was found to have a short processing time and was easier to use. These advantages may improve malaria case management by providing a diagnostic and drug efficacy follow-up tool to peripheral health centres with limited resources.

Published
2011
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44. Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine

Author

Ellis Ruth D, Duan Junhui, Niangaly Amadou, Dicko Alassane, Sagara Issaka, Saye Renion, Takala-Harrison Shannon, Mu Jianbing, Ouattara Amed, Miller Louis H, Su Xin-zhuan, Plowe Christopher V, and Doumbo Ogobara K

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Extensive genetic diversity in vaccine antigens may contribute to the lack of efficacy of blood stage malaria vaccines. Apical membrane antigen-1 (AMA1) is a leading blood stage malaria vaccine candidate with extreme diversity, potentially limiting its efficacy against infection and disease caused by Plasmodium falciparum parasites with diverse forms of AMA1. Methods Three hundred Malian children participated in a Phase 2 clinical trial of a bivalent malaria vaccine that found no protective efficacy. The vaccine consists of recombinant AMA1 based on the 3D7 and FVO strains of P. falciparum adjuvanted with aluminum hydroxide (AMA1-C1). The gene encoding AMA1 was sequenced from P. falciparum infections experienced before and after immunization with the study vaccine or a control vaccine. Sequences of ama1 from infections in the malaria vaccine and control groups were compared with regard to similarity to the vaccine antigens using several measures of genetic diversity. Time to infection with parasites carrying AMA1 haplotypes similar to the vaccine strains with respect to immunologically important polymorphisms and the risk of infection with vaccine strain haplotypes were compared. Results Based on 62 polymorphic AMA1 residues, 186 unique ama1 haplotypes were identified among 315 ama1 sequences that were included in the analysis. Eight infections had ama1 sequences identical to 3D7 while none were identical to FVO. Several measures of genetic diversity showed that ama1 sequences in the malaria vaccine and control groups were comparable both at baseline and during follow up period. Pre- and post-immunization ama1 sequences in both groups all had a similar degree of genetic distance from FVO and 3D7 ama1. No differences were found in the time of first clinical episode or risk of infection with an AMA1 haplotype similar to 3D7 or FVO with respect to a limited set of immunologically important polymorphisms found in the cluster 1 loop of domain I of AMA1. Conclusion This Phase 2 trial of a bivalent AMA1 malaria vaccine found no evidence of vaccine selection or strain-specific efficacy, suggesting that the extreme genetic diversity of AMA1 did not account for failure of the vaccine to provide protection.

Published
2010
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45. Extent and Dynamics of Polymorphism in the Malaria Vaccine Candidate Plasmodium falciparum Reticulocyte–Binding Protein Homologue-5 in Kalifabougou, Mali

Author

Ouattara, Amed, primary, Tran, Tuan M., additional, Doumbo, Safiatou, additional, Adams, Matthew, additional, Agrawal, Sonia, additional, Niangaly, Amadou, additional, Nelson-Owens, Sara, additional, Doumtabé, Didier, additional, Tolo, Youssouf, additional, Ongoiba, Aissata, additional, Takala-Harrison, Shannon, additional, Traoré, Boubacar, additional, Silva, Joana C., additional, Crompton, Peter D., additional, Doumbo, Ogobara K., additional, and Plowe, Christopher V., additional

Published
2018
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46. Spatio-Temporal Dynamics of Asymptomatic Malaria: Bridging the Gap Between Annual Malaria Resurgences in a Sahelian Environment

Author

Coulibaly, Drissa, primary, Travassos, Mark A., additional, Tolo, Youssouf, additional, Laurens, Matthew B., additional, Kone, Abdoulaye K., additional, Traore, Karim, additional, Sissoko, Mody, additional, Niangaly, Amadou, additional, Diarra, Issa, additional, Daou, Modibo, additional, Guindo, Boureima, additional, Rebaudet, Stanislas, additional, Kouriba, Bourema, additional, Dessay, Nadine, additional, Piarroux, Renaud, additional, Plowe, Christopher V., additional, Doumbo, Ogobara K., additional, Thera, Mahamadou A., additional, and Gaudart, Jean, additional

Published
2017
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47. New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali

Author

Dara, Antoine, primary, Drábek, Elliott F., additional, Travassos, Mark A., additional, Moser, Kara A., additional, Delcher, Arthur L., additional, Su, Qi, additional, Hostelley, Timothy, additional, Coulibaly, Drissa, additional, Daou, Modibo, additional, Dembele, Ahmadou, additional, Diarra, Issa, additional, Kone, Abdoulaye K., additional, Kouriba, Bourema, additional, Laurens, Matthew B., additional, Niangaly, Amadou, additional, Traore, Karim, additional, Tolo, Youssouf, additional, Fraser, Claire M., additional, Thera, Mahamadou A., additional, Djimde, Abdoulaye A., additional, Doumbo, Ogobara K., additional, Plowe, Christopher V., additional, and Silva, Joana C., additional

Published
2017
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48. Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine

Author

Laurens, Matthew B., primary, Kouriba, Bourema, additional, Bergmann-Leitner, Elke, additional, Angov, Evelina, additional, Coulibaly, Drissa, additional, Diarra, Issa, additional, Daou, Modibo, additional, Niangaly, Amadou, additional, Blackwelder, William C., additional, Wu, Yukun, additional, Cohen, Joe, additional, Ballou, W. Ripley, additional, Vekemans, Johan, additional, Lanar, David E., additional, Dutta, Sheetij, additional, Diggs, Carter, additional, Soisson, Lorraine, additional, Heppner, D. Gray, additional, Doumbo, Ogobara K., additional, Plowe, Christopher V., additional, and Thera, Mahamadou A., additional

Published
2017
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49. EFFECT OF ARTESUNATE MONOTHERAPY ONPLASMODIUM FALCIPARUMIN VIVO GENOMIC EXPRESSION

Author

Kone, Aminatou, primary, Dara, Antoine, additional, Niangaly, Amadou, additional, Sinha, Indranil, additional, Brodin, David, additional, Fofana, Bakary, additional, Dama, Souleymane, additional, Dembele, Demba, additional, Sidibe, Bakary, additional, Diallo, Nouhoum, additional, Thera, Mahamadou, additional, Sagara, Issaka, additional, Wright, Karin, additional, Björkman, Anders, additional, Gil, Jose, additional, Doumbo, Ogobara, additional, and Djimde, Abdoulaye, additional

Published
2017
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50. Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris-expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1-FVO [25-545]) in healthy Malian adults in Bandiagara

Author

Thera, Mahamadou A., primary, Coulibaly, Drissa, additional, Kone, Abdoulaye K., additional, Guindo, Ando B., additional, Traore, Karim, additional, Sall, Abdourhamane H., additional, Diarra, Issa, additional, Daou, Modibo, additional, Traore, Idrissa M., additional, Tolo, Youssouf, additional, Sissoko, Mady, additional, Niangaly, Amadou, additional, Arama, Charles, additional, Baby, Mounirou, additional, Kouriba, Bourema, additional, Sissoko, Mahamadou S., additional, Sagara, Issaka, additional, Toure, Ousmane B., additional, Dolo, Amagana, additional, Diallo, Dapa A., additional, Remarque, Edmond, additional, Chilengi, Roma, additional, Noor, Ramadhani, additional, Sesay, Sanie, additional, Thomas, Alan, additional, Kocken, Clemens H., additional, Faber, Bart W., additional, Imoukhuede, Egeruan Babatunde, additional, Leroy, Odile, additional, and Doumbo, Ogobara K., additional

Published
2016
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