1. Objectively assessed sleep-disordered breathing during pregnancy and infant birthweight
- Author
-
Grace W. Pien, Chia Ling Nhan-Chang, William A. Grobman, Francesca L. Facco, Jacob C. Larkin, Phyllis P Zee, Hyagriv N. Simhan, David M. Haas, Marquis Hawkins, Uma M. Reddy, Samuel Parry, Nichd NuMoM b, Judette Louis, Nathan R. Blue, Susan Redline, Robert C. Basner, Judith H. Chung, Robert M. Silver, and Corette B. Parker
- Subjects
Reproductive health and childbirth ,Abnormal fetal growth ,Hypoxemia ,Cohort Studies ,0302 clinical medicine ,Pregnancy ,Psychology ,Birth Weight ,Lung ,Pediatric ,Obstetrics ,Incidence (epidemiology) ,Nocturnal hypoxemia ,Gestational age ,Sleep apnea ,General Medicine ,Mental Health ,Infant, Small for Gestational Age ,symbols ,Gestation ,Female ,medicine.symptom ,Sleep Research ,medicine.medical_specialty ,Clinical Sciences ,Gestational Age ,Article ,03 medical and health sciences ,symbols.namesake ,Sleep Apnea Syndromes ,Clinical Research ,medicine ,NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks ,Humans ,Poisson regression ,Sleep-disordered breathing ,Neurology & Neurosurgery ,business.industry ,Prevention ,Infant, Newborn ,Infant ,Newborn ,medicine.disease ,nervous system diseases ,respiratory tract diseases ,030228 respiratory system ,Relative risk ,Small for Gestational Age ,business ,030217 neurology & neurosurgery - Abstract
BackgroundSleep-disordered breathing (SDB) in pregnancy is associated with adverse maternal outcomes. The relationship between SDB and infant birthweight is unclear. This study's primary aim is to determine if objectively measured SDB in pregnancy is associated with infant birthweight.MethodsWe measured SDB objectively in early (6-15 weeks' gestation) and mid (22-31 weeks' gestation) pregnancy in a large cohort of nulliparous women. SDB was defined as an Apnea-Hypopnea Index ≥5 and in secondary analyses we also examined measures of nocturnal hypoxemia. We used a modified Poisson regression approach to estimate relative risks (RR) of large-for-gestational-age (LGA: >90th percentile for gestational age) and small-for-gestational-age (SGA
- Published
- 2021