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Since the death of cultural critic Mark Fisher and the posthumous release of his final lectures Postcapitalist Desire, conversation surrounding his teaching and pedagogy has started to arise. This ...

This article considers a series of ideas disturbing the conventional wisdom that decrees education an essential force in saving the world. Taking Morton's descriptions of hyperobjects seriously, we...

This article seeks to explore the metaphor ‘darkness and light’ and its relevance to education through hauntological study. It draws on the ideas of Derrida and Fisher to reveal that the metaphor f...

This article is an exploration of whether education can be considered a beast-like being, developed by utilising Heidegger’s philosophy to consider education from an ontotheolgical perspective. Edu...

Since 2013, GCSE English Language and Literature courses in England have experienced changes to assessment and curriculum that have ushered them in a supposedly new direction, both under the umbrella of wider GCSE reforms. This divergence has included the abolition of controlled assessment and the concurrent resurgence of academic courses being assessed only by examination. Alongside these changes have been wider reforms to the GCSE system in its totality, with a switch from the typical A* to G grading system to a new 9 to 1 structure. This article is a consideration of these changes and some other caveats of the reform documents released between 2013 and 2015. I am posing this inquiry from my perspective as an English teacher and a poststructuralist, using deconstruction to scrutinise the language in some of the reform documents. Governmental agenda of the reform is explored, demonstrating an archaism to the ‘new’ direction of the GCSE and the hierarchizing of the academic elite in the oppositions presented.

Lyotard’s The Postmodern Condition is a pithy diagnosis of the “status” (3) of knowledge production in the late twentieth century. Much of the text yields important thinking about truth in the post...

A variety of N-linked tertiary amines and heteroarylamines were examined at the 4-position of sulfonylated proline dipeptides in order to improve VLA-4 receptor off-rates and overcome the issue of CYP3A4 time-dependent inhibition of ester prodrugs. A tight-binding inhibitor 5j with a long off-rate provided sustained receptor occupancy despite poor oral pharmacokinetics.

A series of prolyl-N-isonicotinoyl-(L)-4-aminophenylalanine derivatives substituted at the proline 4-position with cyclic amines was evaluated as VLA-4 antagonists. The ring size and presence or absence of fluorine affected potency and receptor occupancy. The analog with 3,3-difluoropiperidine at the proline 4-position (13) was the most potent compound and had very good duration of receptor occupancy in vitro. The ethyl ester prodrug of 13 demonstrated excellent receptor occupancy after oral dosing in rats.

To assess the pharmacokinetics, pharmacodynamics, safety and tolerability of the 5-lipoxygenase-activating protein inhibitor, GSK2190915, after oral dosing in two independent phase I studies, one in Western European and one in Japanese subjects, utilizing different formulations.Western European subjects received single (50-1000 mg) or multiple (10-450 mg) oral doses of GSK2190915 or placebo in a dose-escalating manner. Japanese subjects received three of four GSK2190915 doses (10-200 mg) plus placebo once in a four period crossover design. Blood samples were collected for GSK2190915 concentrations and blood and urine were collected to measure leukotriene B₄ and leukotriene E₄, respectively, as pharmacodynamic markers of drug activity.There was no clear difference in adverse events between placebo and active drug-treated subjects in either study. Maximum plasma concentrations of GSK2190915 and area under the curve increased in a dose-related manner and mean half-life values ranged from 16-34 h. Dose-dependent inhibition of blood leukotriene B₄ production was observed and near complete inhibition of urinary leukotriene E₄ excretion was shown at all doses except the lowest dose. The EC₅₀ values for inhibition of LTB₄ were 85 nM and 89 nM in the Western European and Japanese studies, respectively.GSK2190915 is well-tolerated with pharmacokinetics and pharmacodynamics in Western European and Japanese subjects that support once daily dosing for 24 h inhibition of leukotrienes. Doses of ≥50 mg show near complete inhibition of urinary leukotriene E₄ at 24 h post-dose, whereas doses of ≥150 mg are required for 24 h inhibition of blood LTB₄.

Structure—activity-relationship studies of recently discovered biphenyl acetic acid based DP2 antagonists culminate in the identification of the title compound (I) as a potential candidate for clinical development.