1. Efficacy of stellate ganglion block in treatment of electrical storm: a systematic review and meta-analysis
- Author
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Pouya Motazedian, Nicholas Quinn, George A. Wells, Nickolas Beauregard, Eric Lam, Marie-Eve Mathieu, William Knoll, Graeme Prosperi-Porta, Valentina Ly, Simon Parlow, Pietro Di Santo, Omar Abdel-Razek, Richard Jung, Trevor Simard, Jacob C. Jentzer, Rebecca Mathew, F. Daniel Ramirez, and Benjamin Hibbert more...
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Electrical storm ,Ventricular arrhythmia ,Stellate ganglion block ,Ventricular Electrical Storm ,Systematic Review ,Meta-analysis ,Medicine ,Science - Abstract
Abstract Electrical storm (ES) is a life-threatening condition of recurrent ventricular arrhythmias (VA) in a short period of time. Percutaneous stellate ganglion blockade (SGB) is frequently used – however the efficacy is undefined. The objective of our systematic review was to determine the efficacy of SGB in reducing VA events and mortality among patients with ES. A search of Medline, EMBASE, Scopus, CINAHL and CENTRAL was performed on February 29, 2024 to include studies with adult patients (≥ 18 years) with ES treated with SGB. Our outcomes of interest were VA burden pre- and post-SGB, and in-hospital/30-day mortality. A total of 553 ES episodes in 542 patients from 15 observational studies were included. Treated VAs pre- and post-SGB were pooled from eight studies including 383 patients and demonstrated a decrease from 3.5 (IQR 2.25–7.25) to 0 (IQR 0–0) events (p = 0.008). Complete resolution after SGB occurred in 190 of 294 patients (64.6%). Despite this, in-hospital or 30-day mortality remained high occurring in 140 of 527 patients (random effects prevalence 22%). Repeat SGB for recurrent VAs was performed in 132 of 490 patients (random effects prevalence 21%). In conclusion, observational data suggests SGB may be effective in reducing VAs in ES. Definitive studies for SGB in VA management are needed. Study protocol: PROSPERO - registration number CRD42023430031. more...
- Published
- 2024
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