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The article discusses the real-world effectiveness and drug survival of guselkumab over a 3-year period in treating moderate-to-severe plaque psoriasis, including difficult-to-treat areas. Guselkumab, an anti-IL23 biologic, has shown superior efficacy compared to adalimumab in clinical trials, with sustained high levels of clinical response over 5 years of treatment. Real-life studies have confirmed the effectiveness and safety of guselkumab, particularly in difficult-to-treat areas like scalp, palmoplantar, and genital psoriasis. The study emphasizes the importance of being treatment-naive for achieving complete or almost complete clinical clearance at Week 52. [Extracted from the article]

Background: The complexity, high prevalence, and substantial personal and socioeconomic burden collectively render atopic dermatitis (AD) a major public health concern. Using crowdsourced Internet data has the potential to provide unique insights into this concern, as demonstrated by several previous studies. However, a comprehensive comparison across European countries remains lacking. Objectives: The study aimed to investigate AD‐related web searches across Europe to assess spatiotemporal variations and associations between disease‐related and external factors. Methods: AD‐related web search data were extracted for 21 European countries between February 2019 and January 2023. Descriptive analysis and autocorrelation functions were performed to examine spatiotemporal patterns. Correlations (r) were used to evaluate the associations between web searches and disease‐related, socioeconomic and meteorological data. Results: Over 241 million AD‐related web searches were identified, with search volume varying substantially among European countries (p < 0.001) and correlating with AD prevalence and disease burden (both r = 0.51, p = 0.019). Search volume increased between 2019 and 2023 in all countries and seasonally peaked in January and March. Negative correlations with median population age (r = −0.46, p = 0.039), number of general practitioners (r = −0.29, p = 0.226) and specialists (r = −0.27, p = 0.270) were observed. Moderate to strong correlations were found between search volume and cold, humid and windy weather with fewer sunshine hours, while higher online interest typically occurred 1–3 months after such weather conditions. Conclusion: The study highlights the great potential of online crowdsourced data analysis, for example, to investigate the impact of climate change or to identify unmet needs at a population level. Furthermore, the growing online interest in AD and the corresponding seasonal peaks emphasize the necessity of adapting treatment plans, intensifying public health campaigns, and disseminating reliable online information by governments and healthcare providers, especially during these periods. [ABSTRACT FROM AUTHOR]

Background: Dermatoscopy has been established as an important diagnostic tool for a wide range of skin diseases. This study aims to evaluate the use of dermatoscopy in clinical practice among Greek dermatologists. Methods: A nationwide questionnaire-based survey was conducted collecting data on the frequency of dermatoscopic examinations, the types of lesions examined, training and educational resources, as well as factors influencing the choice to incorporate dermatoscopy into daily clinical routines. Results: A total of 366 Greek dermatologists participated in the survey. Most of the respondents reported the daily use of dermatoscopy in their practice. Pigmented and non-pigmented lesions, inflammatory diseases, cutaneous infectious, hair disorders, and nail lesions were the most common indications for dermatoscopy. Factors influencing the utilization of dermatoscopy included increased diagnostic accuracy, enhanced patient care, better patient communication and general compliance, and improved satisfaction among dermatologists. Conclusions: This national questionnaire-based study demonstrates that dermatoscopy has become an integral part of daily dermatological practice in Greece. The findings highlight the significance of structured training and education to promote dermoscopy's effective and routine use. Incorporating dermatoscopy into clinical practice not only improves diagnostic precision but also enhances patient care, contributing to the overall quality of dermatological services in Greece. [ABSTRACT FROM AUTHOR]

Widespread use of oxidative hair dyes during the past decades has raised questions on the potential allergy reactions and their management, as well as prevention measures for both professionals and consumers. Allergic contact dermatitis can be elicited by various hair dye-related allergens, though the main problem remains with p-phenylenediamine and related aromatic amines. If allergy is suspected, patch testing identifies the responsible hapten. Individuals sensitized to specific permanent hair dyes substances should avoid the exposure to these chemicals, but also be aware of possible cross-sensitization to other similar compounds. Cross-reactions detected in patch-tested populations indicate that one cannot safely use alternatives, although cross-reactivity is not always clinically relevant. An open application hair dye allergy self-test is recommended by manufacturers for early detection of allergy predisposition in consumers, although the lack of standardized conditions makes the efficacy of this process doubtful. Appropriate use of hand gloves, especially nitrile, is the most efficient prevention measure for professional hand eczema. In this systematic review, we focus on cross-reactions among hair dye-related allergens and make an attempt to answer some, frequently encountered by physicians, questions, while presenting the prevalence of the hair dye-related allergens. [ABSTRACT FROM AUTHOR]

This article discusses the various atypical presentations of secondary syphilis in HIV-positive patients. Syphilis is known as "the great imitator" because it can present with a wide range of rashes that resemble other skin conditions. The article presents four case studies of HIV-positive patients with secondary syphilis, each with a different manifestation of the disease. The authors emphasize the importance of early diagnosis and treatment of syphilis, particularly in HIV-positive individuals, and recommend regular STI screening for this population. [Extracted from the article]