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2. Diabetic kidney disease versus non‐diabetic kidney disease in type 2 diabetic patients on dialysis: An observational cohort

Author

Arnaud Delautre, Thierry Hannedouche, Cécile Couchoud, José Guiserix, Damiano Cerasuolo, François Chantrel, Jonas Martzloff, Nicolas Keller, Thierry Krummel, and the REIN registry

Subjects
chronic kidney disease, diabetic kidney disease, mortality, transplantation, type 2 diabetes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Abstract Background All chronic kidney diseases in diabetic patients are not diabetic kidney diseases. The objective was to compare the clinical characteristics, survival and access to transplantation in diabetic patients starting dialysis and classified either as diabetic kidney disease (DKD) or non‐diabetic kidney disease in diabetic patients (NDKD). Methods We used the nationwide French REIN registry to analyse baseline clinical characteristics at dialysis inception and outcomes defined as kidney transplantation, deaths and their causes. The probability of death or transplantation was analysed using a multivariate Cox model and the Fine and Gray competing for risk model (sdHT). Results We included 65,136 patients from January 2009 to December 2015 with a median follow‐up of 31 months. The cumulative incidence of kidney transplantation over eight years was 46.9% (44.8–48.9) in non‐diabetic patients (ND), higher than the 19.3% (17.5–21.2) in the DKD group and 22.2% (18.4–26.7) in the NDKD group. The risk of death was significantly higher in the NDKD group than in the DKD group, even after accounting for the competing risk of transplantation (NDKD/sdHR 1.22; 95%CI 1.18–1.27; p

Published
2022
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4. Wheat domestication accelerated evolution and triggered positive selection in the beta-xylosidase enzyme of Mycosphaerella graminicola.

Author

Patrick C Brunner, Nicolas Keller, and Bruce A McDonald

Subjects
Medicine, Science
Abstract

Plant cell wall degrading enzymes (PCWDEs) of plant pathogens are receiving increasing interest for their potential to trigger plant defense reactions. In an antagonistic co-evolutionary arms race between host and pathogen, PCWDEs could be under strong selection. Here, we tested the hypothesis that PCWDEs in the fungal wheat pathogen Mycosphaerella graminicola have been positively selected by analyzing ratios of non-synonymous and synonymous nucleotide changes in the genes encoding these enzymes. Analyses of five PCWDEs demonstrated that one (beta-xylosidase) has been under strong positive selection and experienced an accelerated rate of evolution. In contrast, PCWDEs in the closest relatives of M. graminicola collected from wild grasses did not show evidence for selection or deviation from a molecular clock. Since the genealogical divergence of M. graminicola from these latter species coincided with the onset of agriculture, we hypothesize that the recent domestication of the host plant and/or agricultural practices triggered positive selection in beta-xylosidase and that this enzyme played a key role in the emergence of a host-specialized pathogen.

Published
2009
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6. TiO2-supported Co catalysts for the hydrogenation of γ-valerolactone to 2-methyltetrahydrofuran: influence of the support

Author

Emilia Soszka, Marcin Jędrzejczyk, Christophe Lefèvre, Dris Ihiawakrim, Nicolas Keller, Agnieszka M. Ruppert, Łódź University of Technology, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Keller, Nicolas

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, [CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, Catalysis
Abstract

International audience; 2-Methyltetrahydrofuran (MTHF) is considered as one of the most promising green fuel alternatives that could be obtained from renewable lignocellulosic biomass through the catalytic hydrogenation of the γ-valerolactone (GVL) platform molecule. In the current work, we report on the ability of earth-abundant non-noble metal Co catalysts supported on TiO2 to be used efficiently for the synthesis of MTHF. The activity of TiO2-supported Co catalysts in the hydrogenation of GVL to 2-MTHF was investigated, and several key factors with significant influence on the reaction have been identified and discussed. Among them, we pointed out the crucial role of the titania support as a versatile tool able to drive the properties of the supported metallic cobalt nanoparticles and consequently the activity of the catalysts. In addition to the necessary catalyst acidity, we showed that the catalyst performances were related to the Co particle size and to the metal–support interaction, both properties being highly dependent on the composition of the titania support. We demonstrated the beneficial co-presence of both anatase and rutile crystalline phases within the TiO2 support, and we proposed that the nature of the crystalline phase not only influences the Co particle size and the catalyst acidity but also allows tuning the SMSI effect for achieving optimum performances in 2-MTHF synthesis.

Published
2022
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7. High‐flow arteriovenous fistula and hemodynamic consequences at 1 year after kidney transplantation

Author

Alexandra Monnier, Nicolas Keller, Bernard Geny, Samy Talha, Noëlle Cognard, Bruno Moulin, and Sophie Caillard

Subjects
medicine.medical_specialty, Cardiac output, business.industry, Fistula, Hemodynamics, Arteriovenous fistula, medicine.disease, Kidney Transplantation, Cohort Studies, Arteriovenous Shunt, Surgical, Renal Dialysis, Nephrology, Internal medicine, Arteriovenous Fistula, medicine, Cardiology, Humans, Prospective Studies, business, High flow, Pathological, Kidney transplantation, Cohort study
Abstract

INTRODUCTION There are only scarce data regarding the cardiovascular impact of arteriovenous fistula after kidney transplantation depending on fistula flow. METHODS We performed a single-center, prospective, cohort study including 49 patients with a functional fistula at 1 year from kidney transplantation. Patients were convened for a clinical work-up, a biological analysis, a fistula's Doppler ultrasonography and an echocardiography. Main judgment criterion was comparison of echocardiography parameters between patients with relative (fistula flow >1 L/min and a fistula flow/cardiac output ratio >20%), absolute high-flow fistula (fistula flow >2 L/min) and normal-flow fistula. RESULTS High-flow fistula frequency was 69%. Significantly higher left ventricular end-diastolic and systolic diameters were observed in this group compared with the normal-flow fistula group (53 ± 6 vs. 48 ± 7 mm; p = 0.04 and 33 ± 6 vs. 28 ± 8 mm; p = 0.02) and between the absolute and relative high-flow fistula subgroups (56 ± 6 vs. 51 ± 6 mm; p = 0.009 and 35 ± 6 vs. 31 ± 5 mm; p = 0.01). The study showed no other significant differences. CONCLUSIONS This study showed a significantly higher but not pathological left ventricular end-diastolic and systolic diameters values in patients with high-flow fistula compared with patients with normal-flow fistula and between patients with respectively absolute and relative high-flow fistula.

Published
2021
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8. Challenges and opportunities for microplastic and nanoplastic removal from industrial wastewater

Author

Didier Robert, Paul Henri Alle, Nicolas Keller, Marie-Antoinette Dzuila, Patricia Garcia-Muñoz, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lorraine (UL), Universidad Politécnica de Madrid (UPM), and Keller, Nicolas

Subjects
[SDE] Environmental Sciences, wastewater treatment processes, [SDE]Environmental Sciences, [CHIM] Chemical Sciences, nanoplastic, [CHIM]Chemical Sciences, [CHIM.CATA] Chemical Sciences/Catalysis, AOPs, [CHIM.CATA]Chemical Sciences/Catalysis, microplastic, photocatalysis, WWTPs
Abstract

International audience; Microplastics (MPs) and nanoplastics (NPs) are ecotoxicological threats because they are able to accumulate and transport toxic metals, persistent organic pollutants or pharmaceuticals products. Consequently, NP pollution is also a public health problem. MP and NP particles arise into surface water bodies and sea water through two major routes: 1) by the transport in the marine environment as synthetic microbeads or microparticles (for example, incorporated into cosmetic products, or during the washing of synthetic clothes) and 2) by the fragmentation of large plastic debris into MPs and NPs, through ultraviolet (UV) photodegradation, biodegradation, mechanical and chemical degradation processes (secondary microplastics). Even if, interest of the scientific community in environmental pollution caused by MP and NP started at the beginning of the 21st century, the research works for reducing and/or removing 2 them in water is very recent. The objective of this chapter is to present the main methods of treatment or removal of MPs and NPs from water, as well as the processes under development.

Published
2023
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10. Contributors

Author

Paul Henri Alle, Ruth Amanna, Anusha Atmakuri, Saeid Avazpour, Seyed Mohammad Mirsoleimani Azizi, Kellie Boyle, Shraddha Chavan, Nimitha Choran, Indramani Dhada, Bipro Ranjan Dhar, Patrick Drogui, Marie-Antoinette Dzuila, Mitra Ebrahimi, Elsayed Elbeshbishy, Mehrzad Feilizadeh, Patricia Garcia-Muñoz, Mohsen Ghasemian, Bhukya Gopal, Nervana Haffiez, Rania Hamza, Farokh Laqa Kakar, M.R. Karimi Estahbanati, Mohammad Kavand, Nicolas Keller, Marthe Kiendrebeogo, Niravkumar Mahendrasinh Kosamia, Lalit R. Kumar, Zannat Mahal, Y. Manojkumar, Zahra Nayernia, Frances Okoye, Victoria Onyedibe, Banu Örmeci, Ashok Pandey, Amrendra Pathak, Arivalagan Periyasamy, Sridhar Pilli, Sudip Kumar Rakshit, Didier Robert, Jorge Rodríguez-Chueca, Sadegh Rostami, Agnieszka M. Ruppert, Kaushal Kishor Sahoo, Mahdieh Samavi, Mohammad Amin Sedghamiz, Lalit Kumar Singh, C. Sumanth, Quiteria Tornero, R.D. Tyagi, Ellen Caroline Silverio Vieira, Bhoomika Yadav, and Basem S. Zakaria

Published
2023
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12. Solar hydrogen production from ethanol-water vapours over metal/TiO2 photocatalysts supported on β-SiC alveolar foams

Author

Patricia García-Muñoz, Javier Ivanez, Víctor A. de la Peña O’Shea, Nicolas Keller, and Fernando Fresno

Subjects
Alveolar β-SiC foam, General Chemistry, Photocatalysis, Catalysis, Solar reactor, Hydrogen, Solar fuels
Abstract

In this work, we have explored the feasibility of alveolar open-cell β-SiC foams as catalyst support for solar hydrogen production. For that purpose, Pt and Ru nanoparticles have been obtained, by means of photoassisted synthesis, on TiO2-coated foams and tested in gas-phase hydrogen production from water-ethanol mixtures in a tubular reactor coupled to a compound parabolic solar collector (CPC). Subnanometre-sized metal or metal/ oxide nanoparticles are obtained for Pt/TiO2/SiC and Ru/TiO2/SiC foams, respectively, where co-catalyst nanoparticles decorate the TiO2 coating which in turn is attached to the SiC foam through an amorphous SiO2 washcoat formed by SiC pre-calcination. In solar photocatalytic reactions, all of the assayed foam-supported photocatalysts are active for the production of hydrogen, with Pt/TiO2 ones being the most active and foam pore size exerting little influence on hydrogen outcome. In the best conditions, 14 % UV-to-hydrogen (equivalent to 0.49 % solar-to-hydrogen) conversion efficiency, with photonic efficiency higher than 30 %, is attained., This work has received financial support from Spanish MCIN/AEI/ 10.13039/501100011033 and "ERDF A way of making Europe", through projects PID2020–118593RB-C22 and ENE2017-89170-R, from Comunidad de Madrid European Structural Funds through FotoArt-CM project (S2018/NMT-4367), and from the European Research Council (ERC) through the HyMAP.

Published
2022
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13. Tixagevimab-cilgavimab as an early treatment for COVID-19 in kidney transplant recipients

Author

Ilies Benotmane, Jérôme Olagne, Gabriela Gautier Vargas, Noëlle Cognard, Francoise Heibel, Laura Braun-Parvez, Nicolas Keller, Jonas Martzloff, Peggy Perrin, Romain Pszczolinski, Bruno Moulin, Samira Fafi-Kremer, and Sophie Caillard

Abstract

ObjectiveThis single-center retrospective study evaluated the use of tixagevimab-cilgavimab as an early treatment for COVID-19 in kidney transplant recipients (KTRs) during the omicron wave.MethodsKTRs were deemed at high risk for moderate-to-severe COVID-19 in presence of at least one comorbidity (age >60 years, diabetes, obesity, or cardiovascular disease) associated with a weak humoral response (ResultsOf the 61 KTRs at high risk, 26 received tixagevimab-cilgavimab. COVID-19-related hospitalizations (3.8% versus 34%, p=0.006) and oxygen need (3.8% versus 23%, p=0.04) were significantly less frequent in patients who received tixagevimab-cilgavimab. In addition, non-significant trends towards a lower number of ICU admissions (3.8% versus 14.3% p=0.17) and deaths (0 versus 3, p=0.13) were observed after administration of tixagevimab-cilgavimab. Ten of the 73 low-risk KTRs received tixagevimab-cilgavimab, and no significant clinical benefit was observed in this subgroup.ConclusionEarly administration of tixagevimab-cilgavimab may be clinically useful in high-risk KTRs with COVID-19; however, no major benefit was observed for low-risk patients.

Published
2022
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14. Breakthrough COVID-19 cases despite prophylaxis with 150 mg of tixagevimab and 150 mg of cilgavimab in kidney transplant recipients

Author

Ilies Benotmane, Aurélie Velay, Gabriela Gautier-Vargas, Jérôme Olagne, Augustin Obrecht, Noëlle Cognard, Françoise Heibel, Laura Braun-Parvez, Nicolas Keller, Jonas Martzloff, Peggy Perrin, Romain Pszczolinski, Bruno Moulin, Samira Fafi-Kremer, Olivier Thaunat, and Sophie Caillard

Subjects
Transplantation, SARS-CoV-2, Immunology and Allergy, Humans, COVID-19, Pharmacology (medical), Sciences du Vivant [q-bio]/Médecine humaine et pathologie, Antibodies, Viral, Kidney Transplantation, Antibodies, Neutralizing
Abstract

The cilgavimab-tixagevimab combination retains a partial in vitro neutralizing activity against the current SARS-CoV-2 variants of concern (omicron BA.1, BA.1.1, and BA.2). Here, we examined whether preexposure prophylaxis with cilgavimab-tixagevimab can effectively protect kidney transplant recipients (KTRs) against the omicron variant. Of the 416 KTRs who received intramuscular prophylactic injections of 150 mg tixagevimab and 150 mg cilgavimab, 39 (9.4%) developed COVID-19. With the exception of one case, all patients were symptomatic. Hospitalization and admission to an intensive care unit were required for 14 (35.9%) and three patients (7.7%), respectively. Two KTRs died of COVID-19-related acute respiratory distress syndrome. SARS-CoV-2 sequencing was carried out in 15 cases (BA.1, n = 5; BA.1.1, n = 9; BA.2, n = 1). Viral neutralizing activity of the serum against the BA.1 variant was negative in the 12 tested patients, suggesting that this prophylactic strategy does not provide sufficient protection against this variant of concern. In summary, preexposure prophylaxis with cilgavimab-tixagevimab at the dose of 150 mg of each antibody does not adequately protect KTRs against omicron. Further clarification of the optimal dosing can assist in our understanding of how best to harness its protective potential.

Published
2022

15. Impact of first-wave COronaVIrus disease 2019 infection in patients on haemoDIALysis in Alsace: the observational COVIDIAL study

Author

Stéphanie Beier, Nicolas Keller, Dorothée Bazin-Kara, Mohamed Brahim-Bouna, Thimothée Nussbaumer, Abdellatif Benmoussa, François Chantrel, Anne Laure Faller, Thierry Krummel, C. Muller, Theirry Hannedouche, Peggy Perrin, and Manfred Ismer

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Pneumonia, Viral, 030232 urology & nephrology, Comorbidity, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Renal Dialysis, Interquartile range, Internal medicine, Epidemiology, Case fatality rate, medicine, Humans, Prospective Studies, 030212 general & internal medicine, AcademicSubjects/MED00340, Prospective cohort study, Pandemics, Aged, Aged, 80 and over, Transplantation, SARS-CoV-2, business.industry, Incidence (epidemiology), Hazard ratio, COVID-19, Lopinavir, Original Articles, mortality, haemodialysis, Survival Rate, C-Reactive Protein, Nephrology, DNA, Viral, Kidney Failure, Chronic, epidemiology, Female, France, Hemodialysis, Coronavirus Infections, business, Biomarkers, medicine.drug
Abstract

Background There are only scarce data regarding the presentation, incidence, severity and outcomes of coronavirus disease 2019 (COVID-19) in patients undergoing long-term haemodialysis (HD). A prospective observational study was conducted in eight HD facilities in Alsace, France, to identify clinical characteristics of HD patients with COVID-19 and to assess the determinants of the risk of death. Methods All HD patients tested positive for COVID-19 from 5 March to 28 April 2020 were included. Collected data included patient characteristics, clinical features at diagnosis, laboratory data, treatments and outcomes. Results Among 1346 HD patients, 123 tested positive for COVID-19. Patients had a median age of 77 years (interquartile range 66–83), with a high number of comorbidities (3.2 ± 1.6 per patient). Symptoms were compatible in 63% of patients. Asthenia (77%), diarrhoea (34%) and anorexia (32%) were frequent at diagnosis. The delay between the onset of symptoms and diagnosis, death or complete recovery was 2 (0–5), 7 (4–11) and 32 (26.5–35) days, respectively. Treatment, including lopinavir/ritonavir, hydroxychloroquine and corticosteroids, was administered in 23% of patients. The median C-reactive protein (CRP) and lymphocyte count at diagnosis was 55 mg/L (IQR 25–106) and 690 Ly/µL (IQR 450–960), respectively. The case fatality rate was 24% and determinants associated with the risk of death were body temperature {hazard ratio [HR] 1.96 [95% confidence interval (CI) 1.11–3.44]; P = 0.02} and CRP at diagnosis [HR 1.01 (95% CI 1.005–1.017); P Conclusions HD patients were found to be at high risk of developing COVID-19 and exhibited a high rate of mortality. While patients presented severe forms of the disease, they often displayed atypical symptoms, with the CRP level being highly associated with the risk of death.

Published
2020
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18. COST Action PRIORITY: An EU Perspective on Micro- and Nanoplastics as Global Issues

Author

Stefania Federici, Zahida Ademovic, Mónica J. B. Amorim, Moritz Bigalke, Mariacristina Cocca, Laura Eleonora Depero, Joydeep Dutta, Wolfgang Fritzsche, Nanna B. Hartmann, Gabriela Kalčikova, Nicolas Keller, Thomas C. Meisel, Denise M. Mitrano, Liam Morrison, Jean-Marie Raquez, Aleksandra Tubić, and Milica Velimirovic

Subjects
microplastics, Mitigation, microplastics, nanoplastics, hazard assessment, remediation, mitigation, analytical procedures, harmonization, metrology, regulatory science, risk management, Microplastics, Remediation, Metrology, risk management, nanoplastics, hazard assessment, mitigation, metrology, Analytical procedures, Regulatory science, Risk management, Harmonization, analytical procedures, harmonization, remediation, regulatory science, Nanoplastics, Hazard assessment
Abstract

Plastic fragments, weathered into or released in the form of micro- and nanoplastics, are persistent and widespread in the environment, and it is anticipated that they have negative environmental impacts. This necessitates immediate efforts for management strategies throughout the entire plastics lifecycle. This opinion paper was initiated by the EU COST Action CA20101 PRIORITY, which focuses on the need to develop an effective global networking platform dealing with research, implementation, and consolidation of ways to address the worldwide challenges associated with micro- and nanoplastics pollution in the environment., Microplastics, 1 (2), ISSN:2673-8929

Published
2022
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19. UV-A light-assisted gas-phase formic acid decomposition on photo-thermo Ru/TiO2 catalyst

Author

Javier Ivanez, Nicolas Keller, Patricia García-Muñoz, Agnieszka M. Ruppert, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Łódź University of Technology, Keller, Nicolas, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Hydrogen, Formic acid, Nanoparticle, chemistry.chemical_element, 02 engineering and technology, Activation energy, 010402 general chemistry, Photochemistry, 7. Clean energy, 01 natural sciences, Catalysis, chemistry.chemical_compound, photothermal, [CHIM] Chemical Sciences, TiO2, [CHIM]Chemical Sciences, Irradiation, [CHIM.MATE] Chemical Sciences/Material chemistry, Light-assisted catalysis, Apparent activation energy, [CHIM.CATA] Chemical Sciences/Catalysis, General Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Decomposition, formic acid decomposition, 0104 chemical sciences, chemistry, 0210 nano-technology, Selectivity, Ru nanoparticles
Abstract

International audience; Although solar energy is considered as one of the ideal abundant sources of renewable energy to be integrated into catalytic processing, photonic and thermal excitations were perceived till recently as independent strategies in overcoming Arrhenius-type activation energy barriers in catalytic reactions. However, this dual-mode excitation of catalysts is receiving a growing interest nowadays due to promising evidence of synergy effects. A Ru/TiO2 photo-thermo-catalyst was prepared according to a UV-A light photo-assisted synthesis method allowing a fine control of the Ru nanoparticle size distribution, and the influence of a combined photonic (UV-A) and thermal activation on its performances in the gas phase decomposition of formic acid into hydrogen was investigated. The results showed that a dual photonic/thermal excitation in a onepot operation allows to increase the formic acid conversion and consequently the production of hydrogen vs. the reaction in the dark, the enhancement being all the more pronounced as the irradiance is high. The combined excitation allowed to drive the reaction at lower temperatures 2 upon irradiation while maintaining a similar conversion level. This low-temperature shift was all the more marked as the irradiance was high, and was accompanied by a strong increase in the selectivity to hydrogen. The change in both conversion and selectivity patterns suggested the implication of the light-excited electrons in the non-plasmonic Ru nanoparticles for conducting the reaction through an alternative low-energy transition state, with a lowering of the apparent energy activation, rather than a mechanism of localized-heat delivery.

Published
2021
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20. High yield production of 2-methyltetrahydrofuran biofuel with reusable Ni-Co catalysts

Author

Emilia Soszka, Marcin Jȩdrzejczyk, Nicolas Keller, Agnieszka M. Ruppert, Łódź University of Technology, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Keller, Nicolas

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, Ni-Co catalysts, General Chemical Engineering, Organic Chemistry, sustainable furanic fuel, gamma-valerolactone, [CHIM.CATA] Chemical Sciences/Catalysis, Energy Engineering and Power Technology, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, Fuel Technology, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, 2-methyltetrahydrofuran
Abstract

International audience; The sustainable production of environmentally-friendly alternative fuels from renewable resources is one of the worldwide high-prospect strategies for future biorefinery schemes. 2methyltetrahydrofuran (2-MTHF) that can be obtained from renewable sources such as lignocellulosic biomass is considered as an ideal green fuel competitive to benchmarks products due to high-value properties like high energy density. In our work we showed that bimetallic Ni-Co/g-Al2O3 catalysts with an appropriate amount of Ni are worth robust, reusable and cheap earth-abundant non-noble metals-based catalysts enabling the high yield production of 2-MTHF. The factors allowing the activity to be strongly boosted compared to the monometallic counterparts while keeping a high selectivity to the targeted 2-MTHF product were identified and discussed. Among the key factors we identified the role of the Ni-Co interaction allowing the Ni availability at the surface of the catalyst to be enhanced. Additionally, the surface acidity was recognized as another important factor. Silica supported catalysts were selective towards the 1,4-pentanediol (1,4-PDO) intermediate obtained by GVL dehydration, while more acidic g-Al2O3 was pushing the reaction further towards 2-MTHF. The synthesis parameters were optimized in terms of reduction temperature (500°C) and Ni:Co ratio (1:4) on the most active g-Al2O3 supported catalyst.

Published
2023
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21. Irradiance-Controlled Photoassisted Synthesis of Sub-Nanometre Sized Ruthenium Nanoparticles as Co-Catalyst for TiO

Author

Patricia, García-Muñoz, Fernando, Fresno, Javier, Ivanez, and Nicolas, Keller

Subjects
TiO2, nanoparticles, photoassisted synthesis, ruthenium, photocatalysis, Article
Abstract

Photoassisted synthesis is as a highly appealing green procedure for controlled decoration of semiconductor catalysts with co-catalyst nanoparticles, which can be carried out without the concourse of elevated temperatures, external chemical reducing agents or applied bias potential and in a simple slurry reactor. The aim of this study is to evaluate the control that such a photoassisted method can exert on the properties of ruthenium nanoparticles supported on TiO2 by means of the variation of the incident irradiance and hence of the photodeposition rate. For that purpose, different Ru/TiO2 systems with the same metal load have been prepared under varying irradiance and characterized by means of elemental analysis, transmission electron microscopy and X-ray photoelectron spectroscopy. The photocatalytic activity of the so-obtained materials has been evaluated by using the degradation of formic acid in water under UV-A light. Particles with size around or below one nanometer were obtained, depending on the irradiance employed in the synthesis, with narrow size distribution and homogeneous dispersion over the titania support. The relation between neutral and positive oxidation states of ruthenium could also be controlled by the variation of the irradiance. The obtained photocatalytic activities for formic acid oxidation were in all cases higher than that of undecorated titania, with the sample obtained with the lowest irradiation giving rise to the highest oxidation rate. According to the catalysts characterization, photocatalytic activity is influenced by both Ru size and Ru0/Ruδ+ ratio.

Published
2021

22. Hemodialysis without anticoagulation: Less clotting in conventional hemodialysis than in predilution hemodiafiltration

Author

Etienne Cellot, Géraldine De Geyer, Thierry Krummel, Thierry Hannedouche, Alicia Thiery, and Nicolas Keller

Subjects
Male, Nephrology, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, Hemodiafiltration, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Renal Dialysis, Internal medicine, medicine, Humans, Prospective Studies, Blood Coagulation, Contraindication, Dialysis, Survival analysis, business.industry, Hematology, Heparin, Middle Aged, Hemodialysis technique, Anesthesia, Kidney Failure, Chronic, Female, Systemic anticoagulation, Hemodialysis, business, medicine.drug
Abstract

INTRODUCTION Hemodialysis patients with contraindication to systemic anticoagulation require a heparin-free hemodialysis technique. Among several alternatives to heparin, predilution hemodiafiltration (HDF) is often used, albeit without any confirmation of its effectiveness. METHODS Patients hospitalized in a nephrology ICU and hemodialysed for stage 5 CKD or AKI and with contraindication to systemic anticoagulation were randomized to either standard HD with a polysulfone membrane, or to predilution HDF with the same membrane. Coagulation activation was evaluated clinically by the need for premature termination and by the measurement of D-dimers. FINDINGS Two hundred dialysis sessions were performed in 155 patients. Survival curves showed better circuit survival in HD (P = 0.046). In HD, 12% of sessions were interrupted for coagulation versus 23% in predilution HDF (P = 0.04). DISCUSSION Predilution HDF was associated with more premature clotting than conventional HD without improvement in dialysis duration or performance epuration indices. When aiming for a 4-hour duration session, conventional heparin-free hemodialysis can be safely proposed in most patients with high bleeding risk.

Published
2019
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23. Médicaments du système cardiovasculaire et fonction rénale : les pièges de l’adaptation rénale

Author

Marie Ruppert, Thierry Hannedouche, Marion Fourtage, and Nicolas Keller

Subjects
03 medical and health sciences, 0302 clinical medicine, Nephrology, 030232 urology & nephrology
Abstract

Resume Introduction L’insuffisance renale chronique est associee a une probabilite importante de recevoir un traitement a visee cardiovasculaire. La Haute Autorite de sante recommande toujours l’usage de la formule de Cockcroft et Gault pour l’adaptation posologique, sous pretexte qu’il s’agit de la principale donnee disponible dans la base du Vidal®. Afin de verifier ce postulat, nous avons realise une revue systematique de la base Vidal® en recherchant la methode preconisee pour l’evaluation de la fonction renale en vue de l’adaptation posologique des medicaments a visee cardiovasculaire. Materiel et methode Les fiches Vidal® et resume des caracteristiques des produits (RCP) des medicaments a visee cardiovasculaire (categories B01 et C de la classification ATC) ont ete analysees et classees selon la formule d’evaluation de la fonction renale preconisee pour les adaptations posologiques. Resultats En tout, 196 molecules ont ete identifiees, dont 62,6 % requeraient une adaptation posologique a la fonction renale. La methode d’evaluation la plus utilisee etait la clairance de la creatinine (sans precision concernant la methode d’evaluation ou de mesure) avec une frequence de 35,5 %. La frequence d’utilisation de la formule de Cockcroft et Gault etait de 3,9 % (8,4 % apres revue de la litterature concernant les molecules enoncant la clairance de la creatinine, comme methode de reference). Conclusion L’utilisation privilegiee de la formule de Cockcroft et Gault pour l’adaptation posologique, comme recommandee par la Haute Autorite de sante, ne semble pas fondee. Une refonte des recommandations concernant les etudes de pharmacocinetique et les methodes d’evaluation de la fonction renale pour les adaptations posologiques semble necessaire.

Published
2019
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26. Diabetic kidney disease versus non-diabetic kidney disease in type 2 diabetic patients on dialysis: An observational cohort

Author

Arnaud, Delautre, Thierry, Hannedouche, Cécile, Couchoud, José, Guiserix, Damiano, Cerasuolo, François, Chantrel, Jonas, Martzloff, Nicolas, Keller, and Thierry, Krummel

Subjects
Cohort Studies, Diabetes Mellitus, Type 2, Renal Dialysis, Endocrinology, Diabetes and Metabolism, Humans, Diabetic Nephropathies, Kidney Transplantation
Abstract

All chronic kidney diseases in diabetic patients are not diabetic kidney diseases. The objective was to compare the clinical characteristics, survival and access to transplantation in diabetic patients starting dialysis and classified either as diabetic kidney disease (DKD) or non-diabetic kidney disease in diabetic patients (NDKD).We used the nationwide French REIN registry to analyse baseline clinical characteristics at dialysis inception and outcomes defined as kidney transplantation, deaths and their causes. The probability of death or transplantation was analysed using a multivariate Cox model and the Fine and Gray competing for risk model (sdHT).We included 65,136 patients from January 2009 to December 2015 with a median follow-up of 31 months. The cumulative incidence of kidney transplantation over eight years was 46.9% (44.8-48.9) in non-diabetic patients (ND), higher than the 19.3% (17.5-21.2) in the DKD group and 22.2% (18.4-26.7) in the NDKD group. The risk of death was significantly higher in the NDKD group than in the DKD group, even after accounting for the competing risk of transplantation (NDKD/sdHR 1.22; 95%CI 1.18-1.27; p 0.005 vs. DKD/sdHR 1.12; 95%CI 1.08-1.16; p 0.005 with adjustment for age, sex, major adverse cardiovascular events, cancer and chronic respiratory failure, compared to ND).In diabetic patients starting dialysis, patients in the DKD group had reduced access to kidney transplantation. NDKD patients had a higher risk of mortality than DKD. The distinction between DKD and NDKD should be accounted for in the plan of care of diabetic patients starting dialysis.

Published
2021

27. Effects of high- vs low-dose native vitamin D on albuminuria and the renin-angiotensin-aldosterone system: a randomized pilot study

Author

Nicolas Keller, Maxime Ingwiller, Emmanuelle Charlin, Dorothée Bazin, Thierry Hannedouche, Thierry Krummel, and Eric Prinz

Subjects
medicine.medical_specialty, Urology, Pilot Projects, Renin-Angiotensin System, chemistry.chemical_compound, Internal medicine, medicine, Vitamin D and neurology, Albuminuria, Humans, Vitamin D, Creatinine, Aldosterone, business.industry, Captopril, Vitamin D Deficiency, Ergocalciferol, Blood pressure, Endocrinology, chemistry, Nephrology, medicine.symptom, business, Cholecalciferol, medicine.drug
Abstract

Residual albuminuria is associated with an increased risk of progression to ESKD. We tested whether a supplementation with native vitamin D could reduce albuminuria in stable CKD patients under maximal renin-angiotensin system (RAS) blockade. We conducted a randomized controlled study of high (cholecalciferol 100 000 UI per 10 days over 1 month) vs low-dose (ergocalciferol 400 UI/days over 1 month) supplementation with native vitamin D on urinary albumin/creatinine ratio, blood pressure and the RAS over 1 month in stable CKD patients with albuminuria and maximum tolerated RAS blockade. We included 31 patients, 21 in the high dose group and 10 in the low dose group. In contrast with a low dose, high dose vitamin D normalized plasma 25(OH)D, decreased iPTH but slightly increased plasma phosphate. High dose vitamin D decreased geometric mean UACR from 99.8 mg/mmol (CI 95% 60.4–165.1) to 84.7 mg/mmol (CI 95% 51.7–138.8, p = 0.046). In the low dose group, the change in geometric mean UACR was not significant. Blood pressure, urinary 24 h aldosterone and peaks and AUC of active renin concentrations after acute stimulation by a single dose of 100 mg captopril were unaffected by the supplementation in native vitamin D, irrespective of the dose. Native vitamin D supplementation was well tolerated. We found a small (− 15%) but significant decrease in albuminuria after high dose vitamin D supplementation. We found no effect of vitamin D repletion on blood pressure and the systemic RAS, concordant with recent clinical studies.

Published
2021

28. Modified-TiO2 Photocatalyst Supported on β-SiC Foams for the Elimination of Gaseous Diethyl Sulfide as an Analog for Chemical Warfare Agent: Towards the Development of a Photoreactor Prototype

Author

Valérie Keller, Armelle Sengele, Didier Robert, Nicolas Keller, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Keller, Nicolas, Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Chemical Warfare Agents, doped TiO 2, Diethyl sulfide, chemistry.chemical_element, Context (language use), Polyethylene glycol, 010501 environmental sciences, 010402 general chemistry, lcsh:Chemical technology, 01 natural sciences, Catalysis, lcsh:Chemistry, chemistry.chemical_compound, Adsorption, lcsh:TP1-1185, Physical and Theoretical Chemistry, 0105 earth and related environmental sciences, [CHIM.MATE] Chemical Sciences/Material chemistry, Chemistry, doped TiO2, [CHIM.CATA] Chemical Sciences/Catalysis, diethyl sulfide, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, Sulfur, 0104 chemical sciences, Chemical engineering, lcsh:QD1-999, β-SiC foams, Photocatalysis, photocatalysis
Abstract

In the context of the increase in chemical threat due to warfare agents, the development of efficient methods for destruction of Chemical Warfare Agents (CWAs) are of first importance both for civilian and military purposes. Amongst possible methods for destruction of CWAs, photocatalytic oxidation is an alternative one. The present paper reports on the preparation of Ta and Sn doped TiO2 photocatalysts immobilized on β-SiC foams for the elimination of diethyl sulfide (DES) used as a model molecule mimicking Yperite (Mustard Gas) in gaseous phase. Photo-oxidation efficiency of doped TiO2 catalyst has been compared with TiO2-P25. Here, we demonstrate that the Sn doped-TiO2 with a Polyethylene glycol (PEG)/TiO2 ratio of 7 exhibits the best initial activity (up to 90%) but is deactivates more quickly than Ta doped-TiO2 (40% after 800 min). The activity of the catalysts is strongly influenced by the adsorption properties of the support, as β-SiC foams adsorb DES and other sulfur compounds. This adsorption makes it possible to limit the poisoning of the catalysts and to maintain an acceptable conversion rate even after ten hours under continuous DES flow. Washing with NaOH completely regenerates the catalyst after a firs treatment and even seems to “wash” it by removing impurities initially present on the foams.

Published
2021
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29. TiO2 and TiO2-Carbon Hybrid Photocatalysts for Diuron Removal from Water

Author

Nicolas Keller, Patricia García-Muñoz, Ana Amorós-Pérez, M.C. Román-Martínez, Maria Angeles Lillo-Rodenas, Universidad de Alicante, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Universidad de Alicante. Departamento de Química Inorgánica, Universidad de Alicante. Instituto Universitario de Materiales, Materiales Carbonosos y Medio Ambiente, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and univOAK, Archive ouverte

Subjects
Activated carbon, chemistry.chemical_element, 02 engineering and technology, lcsh:Chemical technology, 010402 general chemistry, solar chamber, 7. Clean energy, 01 natural sciences, Catalysis, Solar chamber, lcsh:Chemistry, Hydrothermal carbonization, Adsorption, medicine, TiO2, lcsh:TP1-1185, activated carbon, Photocatalysis, Physical and Theoretical Chemistry, Photocatalytic degradation, Photodegradation, Química Inorgánica, [SDE.IE]Environmental Sciences/Environmental Engineering, [CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, 021001 nanoscience & nanotechnology, 0104 chemical sciences, diuron, lcsh:QD1-999, chemistry, Diuron, [SDE.IE] Environmental Sciences/Environmental Engineering, 0210 nano-technology, Carbon, photocatalysis, medicine.drug, Nuclear chemistry
Abstract

TiO2 and TiO2-activated carbon (AC) photocatalysts have been prepared (by sol-gel synthesis), characterized, and tested in the removal of diuron from water under simulated solar light. The preparation variables of the two series of catalysts are: (i) heat-treatment temperature of bare TiO2 (350, 400, 450 and 500 °C) and (ii) activated carbon content (0.5, 1, 5, and 10 wt.%) in TiO2-AC samples heat-treated at 350 °C. The activated carbon was previously prepared by hydrothermal carbonization of saccharose and has spherical shape. The heat-treatment temperature does not determine the efficiency of TiO2 for diuron photocatalytic degradation but clearly influences the diuron adsorption capacity. The capacity of TiO2-AC samples for diuron removal increases with the carbon content and it is the result of combined diuron adsorption and photodegradation. Thus, the sample with highest carbon content (10 wt.% nominal) leads to the highest diuron removal. The TiO2-AC photocatalysts have proved to be capable of degrading diuron previously adsorbed in dark conditions, which allows their regeneration. This research was funded by the Spanish Ministry of Science, Innovation and Universities, MICIU, and Fondo Europeo de Desarrollo Regional, FEDER, (RTI2018-095291-B-I00), by Generalitat Valenciana and FEDER (GV/FEDER (PROMETEO/2018/076)) and by the University of Alicante (VIGROB-136).

Published
2021
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30. Virtually Transparent TiO2 /Polyelectrolyte Thin Multilayer Films as High-Efficiency Nanoporous Photocatalytic Coatings for Breaking Down Formic Acid and for Escherichia coli Removal

Author

David Martel, Bertrand Vileno, Gero Decher, Maria Guadalupe Méndez-Medrano, Christophe Colbeau-Justin, Lydie Ploux, Charline Soraru, Nicolas Keller, Marvin Motay, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nanocomposite, Materials science, Nanoporous, Scanning electron microscope, Chimie/Matériaux, Quartz crystal microbalance, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, Polyelectrolyte, Chemical engineering, 13. Climate action, Ellipsometry, Photocatalysis, General Materials Science, Crystallite, Chimie/Catalyse, ComputingMilieux_MISCELLANEOUS
Abstract

Virtually transparent photocatalytic multilayer films composed of TiO2 nanoparticles and polyelectrolytes were built on model surfaces using layer-by-layer assembly and investigated as photocatalytic nanoporous coatings. Formic acid (HCOOH) and Escherichia coli were used as models for the degradation of gaseous pollutants and for studying antibacterial properties. Positively charged TiO2 nanoparticles were coassembled with negatively charged poly(sodium 4-styrenesulfonate) (NaPSS) which leads to highly transparent nanoscale coatings in which the content of TiO2 particles is controlled mainly by the number of deposition cycles and the enhanced translucency with respect to titania powders is likely due to the presence of the polyelectrolytes in the interstitial space between the particles. Build-up and structural properties of the films were determined by ellipsometry, quartz crystal microbalance (QCM-D, with dissipation monitoring), and UV-vis spectrophotometry in transmission and scanning electron microscopy. Complementary photophysical and activity tests of (PSS/TiO2)n multilayer films were performed in the gas-phase under UV-A light and revealed a peculiar dependence on the number of layer pairs (LPs), corresponding to a clear deviation from the usual observations in photocatalysis with increasing TiO2 amounts. Most notably, a single LP film showed a strongly enhanced HCOOH mineralization and outperformed films with a higher number of LPs, with respect to the quantity of TiO2 catalyst present in the films. It is believed that the high quantum yield (8.1%) of a coating consisting of a single TiO2 layer which is 6-7 times higher than that of a 6-10 LP film could be due to the optimum accessibility of the TiO2 crystallites toward both HCOOH and water molecules. In thicker films, while no detrimental light screening was observed with increasing the number of LPs, diffusion phenomena could cap the efficiency of the access of the pollutant and water to the catalytic surface. Unlike for HCOOH mineralization, three PSS/TiO2 LPs were required for observing a maximum antibacterial activity of the nanocomposite coatings. This is likely due to the fact that micrometer-sized E. coli bacteria do not enter into the interstitial space between the TiO2 particles and require a different surface morphology with respect to the number of active contact points for optimum degradation.

Published
2020
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31. Ti-Modified LaFeO

Author

Patricia, García-Muñoz, Fernando, Fresno, Christophe, Lefevre, Didier, Robert, and Nicolas, Keller

Abstract

Ti-modified LaFeO

Published
2020

32. Ti-Modified LaFeO 3 /β-SiC Alveolar Foams as Immobilized Dual Catalysts with Combined Photo-Fenton and Photocatalytic Activity

Author

Nicolas Keller, Christophe Lefevre, Fernando Fresno, Patricia García-Muñoz, Didier Robert, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, 02 engineering and technology, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 7. Clean energy, 01 natural sciences, Peroxide, 0104 chemical sciences, Catalysis, Amorphous solid, Reaction rate, chemistry.chemical_compound, Chemical engineering, chemistry, Photocatalysis, General Materials Science, Water treatment, Leaching (metallurgy), 0210 nano-technology, Incipient wetness impregnation, ComputingMilieux_MISCELLANEOUS
Abstract

Ti-modified LaFeO3/β-SiC alveolar foams were used as immobilized, highly robust dual catalysts with combined photocatalytic wet peroxide oxidation and photocatalytic activity under UV-A light. They were prepared by incipient wetness impregnation of a β-SiC foam support, by implementing a sol-gel Pechini synthesis at the foam surface in the presence of dried amorphous sol-gel titania as a titanium source. The physicochemical and catalytic features suggest the stabilization at the foam surface of a substituted La1-xTixFeO3 catalyst analogous to its powdery counterpart. Taking 4-chlorophenol removal in water as a model reaction, its dual nature enables both high reaction rates and full total organic carbon (TOC) conversion because of a synergy effect, while its macroscopic structure overcomes the drawback of working with powdery catalysts. Further, it yields photonic efficiencies for degradation and mineralization of ca. 9.4 and 38%, respectively, that strongly outperform those obtained with a reference TiO2 P25/β-SiC foam photocatalyst. The enhancement of the catalyst robustness upon Ti modification prevents any Fe leaching to the solution, and therefore, the optimized macroscopic foam catalyst with 10 wt % catalyst loading operates through pure heterogeneous surface reactions, without any activity loss during reusability test cycles.

Published
2020
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33. Virtually Transparent TiO

Author

Marvin, Motay, David, Martel, Bertrand, Vileno, Charline, Soraru, Lydie, Ploux, María Guadalupe, Méndez-Medrano, Christophe, Colbeau-Justin, Gero, Decher, and Nicolas, Keller

Subjects
Titanium, Nanopores, Formates, Polymers, Surface Properties, Ultraviolet Rays, Escherichia coli, Polyelectrolytes, Catalysis, Anti-Bacterial Agents
Abstract

Virtually transparent photocatalytic multilayer films composed of TiO

Published
2020

34. Virtually Transparent TiO 2 /Polyelectrolyte Thin Multilayer Films as High Efficiency Nanoporous Photocatalytic Coatings for Breaking Down Formic Acid and for Escherichia Coli Removal

Author

Marvin Motay, David Martel, Bertrand Vileno, Charline Soraru, Lydie Ploux, María Guadalupe Méndez-Medrano, Christophe Colbeau-Justin, Gero Decher, Nicolas Keller, Université de Strasbourg (UNISTRA), and Martel, David

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

35. Activity enhancement pathways in LaFeO3@TiO2 heterojunction photocatalysts for visible and solar light driven degradation of myclobutanil pesticide in water

Author

Nicolas Keller, Didier Robert, Fernando Fresno, Patricia García-Muñoz, Javier Ivanez, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Reaction mechanism, Environmental Engineering, Materials science, Health, Toxicology and Mutagenesis, Myclobutanil, Composite number, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, solar light, chemistry.chemical_compound, Environmental Chemistry, [CHIM]Chemical Sciences, myclobutanil pesticide, Waste Management and Disposal, visible light, Heterojunction, water treatment, [CHIM.CATA]Chemical Sciences/Catalysis, 021001 nanoscience & nanotechnology, Pollution, LaFeO3/TiO2 heterojunction, 0104 chemical sciences, chemistry, Chemical engineering, Photocatalysis, Degradation (geology), Water treatment, 0210 nano-technology, photocatalysis, Visible spectrum
Abstract

International audience; TiO2@LaFeO3 heterojunction composites with a core-shell porous structure and LaFeO3 contents in the 2.5-25 wt.% range have been synthesized via consecutive sol-gel syntheses and tested for the photocatalytic oxidation of the myclobutanil pesticide in water under solar light and pure visible light. Whatever the light spectrum, the kinetic rate constants for both myclobutanil degradation and TOC conversion exhibited a volcano-like profile with increasing the narrow band-gap (2.1 eV) LaFeO3 content, the optimum composite strongly overperforming both single phases, with full myclobutanil mineralization achieved in 240 min in the best case. The light spectrum influenced the optimum LaFeO3 content in the composite, being observed at 5 wt.% and 12.5 wt.% under solar and visible light, respectively. This has been attributed to the existence of different light-mediated reaction mechanisms. The optimum LaFeO3/TiO2 composite photocatalyst was active and stable after several runs under solar light with leached iron concentration below 0.1 mg/L in solution.

Published
2020
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36. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author

Cécile Couchoud, Florian Bayer, Carole Ayav, Clémence Béchade, Philippe Brunet, François Chantrel, Luc Frimat, Roula Galland, Maryvonne Hourmant, Emmanuelle Laurain, Thierry Lobbedez, Lucile Mercadal, Olivier Moranne, Abdelhamid Abbassi, Alain Debure, Abdallah Guerraoui, Abdelatif Benmoussa, Abdelaziz Hamani, Abdelaziz Ziane, Abdelhamid Nefti, Abdelkader Hadj, Abderrahim El Amari, Abderrahmane Ghazali, Abo Bakr Abd El Fatah Mohamed, Achour Laradi, Adel Ben Ahmed, Adel Sahar, Adele Pillet, Adeline Lacraz, Adnan Moinat, Afshin Massoumi, Agathe Pardon, Agnes Caillette Beaudoin, Agnes Chapelet Debout, Agnes Mariot, Ahmed Rachi, Aida Afiani, Aime Remy Boula, Al Jalaby, Alain Cremault, Alain Fournier, Alain Jeanson, Alain Lyon, Alain Nony, Alain Robert, Alain Slingeneyer, Alanor Agnes Labatide, Albane Brodin Sartorius, Albert Bensman, Albert Fournier, Alex Ranlin, Alex Vido Sandor, Alexandra Colombo, Alexandra Duhem, Alexandra Stancu, Alexandre Dufay, Alexandre Dumoulin, Alexandre Ebel, Alexandre Klein, Alexandre Martin, Alexandre Mouneimne, Alexandre Seidowsky, Alfio De Martin, Alfredo Zannier, Ali Aizel, Ali Hafi, Ali Zineddine Diddaoui, Alim Heyani, Alina Mocanu, Alina Preda, Aline Hafi, Aline Talaszka, Alyette Duquesne, Amar Amaouche, Amel Ghemmour, Amelie Simon, Amina Skalli, Amine Boukadida, Amr Ekhlas Ragab Eid, Ana Fedorca, Anabelle Baillet, Anais Poyet, Ancuta Bouffandeau Giorgita, Anderson Ratsimbazafy, Andre Pruna, Angel Argiles, Angelo Testa, Ann Karolien Vandooren, Anne Jolivot, Anne Kolko Labadens, Anne Lataste, Anne Maisin, Anne Paris, Anne Sechet, Anne Wuillai, Anne Elisabeth Heng, Anne Gaelle Josse, Anne Helene Querard, Anne Helene Reboux, Anne Laure Adra, Anne Laure Faller, Anne Laure Leclerc, Anne Laure Poitou, Annie Lahoche Manucci, Antoine Jacquet, Antoine Pommereau, Antoine Thierry, Arezki Adem, Arielle Chapelet, Arnaud Del Bello, Arnaud Delezire, Arnaud Garnier, Arnaud Guerard, Arnaud Klisnick, Arnaud Lionet, Arnaud Roccabianca, Arnaud Stolz, Arthur Capdeville, Asma Allal, Assem Alrifai, Assetou Diarrassouba, Assia Djema, Assia Ferhat Carre, Astrid Godron Dubrasquet, Atman Haddj Elmrabet, Audrey Jegado, Aurelia Bertholet Thomas, Aurelie Davourie Salandre, Aurelie Pajot, Aurelien Lorthioir, Aurelien Tiple, Aurore Sury, Ayman Abokasem, Ayman Sarraj, Bachir Henaoui, Baher Chaghouri, Bassem Wehbe, Beatrice Ball, Beatrice Viron, Belkassem Issad, Benedicte Hodemon Corne, Benedicte Janbon, Benjamin Deroure, Benjamin Savenkoff, Benoit Jonon, Benoit Vendrely, Benyakoub Djelaleddine, Bernard Ohry, Bernard Painchart, Bernard Strullu, Bernard Temperville, Bertin Ebikili, Bertrand Hacq, Bertrand Morel, Bilal Aoun, Blanca Muniz, Bouchra Chlih, Brahim Amara, Brice Mayor, Brigitte Gilson, Brigitte Llanas, Brigitte Zins, Bruno Bourgeon, Bruno Coevoet, Bruno Guery, Bruno Legallicier, Bruno Paris, Bruno Ranchin, Bruno Seigneuric, Camelia Ghiciuc Dita, Camelia Prelipcean, Carine Achard Hottelart, Carine Diet, Carlos Frangie, Carlos Vela, Carmina Muresan, Carole Deprele, Caroline Araujo, Caroline Bidault, Caroline Creput, Caroline Delclaux, Caroline Du Halgouet, Caroline Favennec, Caroline Freguin, Caroline Gourraud Vercel, Caroline Mesguen, Caroline Ndomo Obama, Caroline Poitou, Caroline Preissig Dirhold, Caroline Roubiou, Catherine Albert, Catherine Bessin, Catherine De Marion Gaja, Catherine Godart, Catherine Lasseur, Catherine Leocardi, Catherine Lumbroso, Catherine Melander, Catherine Michel, Catherine Quere Maurouard, Catherine Rouannet, Catherine Taddei, Cathy Verove, Cecile Guiraud, Cecile Tafelin, Cecile Turc Baron, Cedric Formet, Cedric Pinier, Celia Lessore De Ste Foy, Celine Granolleras, Chaouki Bennini, Charles Cartou, Charles Chazot, Charlotte Jouzel, Cherif Badid, Christa Roubicek, Christel Viaud, Christelle Verrier, Christian Chuet, Christian Combe, Christian Dabot, Christian Duvic, Christian Emond, Christian Lagarde, Christian Lamotte, Christian Pain, Christiane Mousson, Christie Lorriaux, Christine Beauchamp, Christine Fumeron, Christine Le Gurun, Christine Leroy, Christine Pietrement, Christine Richer, Christophe Bouaka, Christophe Charasse, Christophe Goupy, Christophe Ridel, Cindy Castrale, Cindy Detourne, Clair Francois, Claire Presne, Claire Trivin, Clarissa Von Kotze, Claude Bernard, Claude Bonniol, Claude Desvergnes, Claude Raharivelina, Claudia Nistor, Claudine Gueret, Claudine Lloret, Claudine Saltiel, Clelia Rosati, Clementine Rabate, Corina Stanescu, Corinne Ferrandini, Corinne Guibergia, Corinne Lemoine, Corinne Passeron, Cynthia Kahil, Cyril Garrouste, Cyril Vo Van, Cyrille Jolimoy, Dalila Kesraoui, Damien Jolly, Damien Thibaudin, Dan Teboulle, Daniel Daubresse, Daniel Louvet, Daniel Rasamimanantsoa, Daniel Toledano, Daniela Babici, Daniela David, Daniela Dincu, Danielle Bruno, Delia May, Delphine Haussaire, Delphine Henriet Viprey, Denis Bugnon, Denis Fouque, Denis Morin, Derradji Nour, Diab Mohamed Mahmoud, Diana Istrati Cristescu, Didier Aguilera, Didier Coste, Didier Hamel, Didier Le Chapois, Didier Testou, Dilaver Erbilgin, Djamal Dahmane, Doan Bui Quang, Dominique Bertrand, Dominique Besnier, Dominique Blanchier, Dominique Briffa, Dominique Caux, Dominique Durand, Dominique Fleury, Dominique Guerrot, Dominique Hestin, Dominique Jaubert, Dominique Joly, Dominique Lombart, Dominique Pagniez, Dominique Pierre, Dominique Schohn, Donatien Ikonga, Dorina Visanica, Dorothee Bazin, Edouard Boury, Edouard Maksour, Ekoue Agbonon, Elarbi Harrami, Elena Marcu, Elena Tudorache, Elisabeth Caniot, Elisabeth Semjen, Elisabeth Tomkiewicz, Elise Scheidt, Elke Gaboriau, Elodie Lamouroux, Elsa Guiard, Elsa Martin Passos, Emerson Nsembani, Emilie Fache, Emilie Kalbacher, Emilie Pambrun, Emilie Pincon, Emma Allain Launay, Emmanuel Baron, Emmanuel Dupuis, Emmanuel Villar, Emmanuelle Charlin, Emmanuelle Hecquet, Emmanuelle Kohler, Emmanuelle Rosier, Enrique Figueroa, Eric Azoulay, Eric Canivet, Eric Daugas, Eric Gauthier, Eric Laruelle, Eric Le Guen, Eric Legrand, Eric Moumas, Eric Postec, Eric Prinz, Eric Renaudineau, Estelle Desport, Estelle Ricard Sutra, Etienne Berard, Etienne Ged, Etienne Robin, Eve Vilaine, Evelyne Bargas, Evelyne Mac Namara, François Combarnous, Fatima Yazbeck, Fabien Gerard, Fabien Metivier, Fabien Parazols, Fabien Soulis, Fabrice Garnier, Fadhila Pech Messaoudene, Fadi Haidar, Fanny Boullenger, Fanny Lepeytre, Fanny Leroy, Fares Frejate, Farid Bellahsene, Farid Bellhasene, Farid Saidani, Fatouma Toure, Faycal Kriaa, Fazia Nemmar, Fernando Vetromile, Florence Chalmin, Florence Lucats, Florence Sens, Florence Villemain, Florent Plasse, Fouad Lebhour, Francis Schillinger, Franck Berge, Franck Bourdon, Franck Bridoux, Franck Reynaud, Francois Babinet, Francois Basse, Francois Chantrel, Francois Clair, Francois Coulomb, Francois De Cornelissen, Francois Glowacki, Francois Marchal, Francois Maurice, Francois Nobili, Francois Pourreau, Francois Provot, Francois Roux Amani, Francoise Broux, Francoise Bulte, Francoise Heibel, Francoise Leonetti, Francoise Moussion Schott, Frank Le Roy, Frederic Besson, Frederic Lavainne, Frederic Tollis, Frederique Bocquentin, Frederique Meeus, Frederique Vecina, Friederike Von Ey, Gabriel Balit, Gabriel Choukroun, Gabriel Gruget, Gabriel Huchard, Gabriella Golea, Gabrielle Duneau, Gaelle Lefrancois, Gaelle Pelle, Gaetan Lebrun, Genevieve Dumont, Georges Brillet, Georges Deschenes, Georges Mourad, Georges Stamatakis, Geraldine Cazajous, Geraldine D'ythurbide, Geraldine Robitaille Wiart, Gerard Cardon, Gerard Champion, Gerard Deschodt, Gerard Mangenot, Gerard Motte, Gerard Schortgen, Ghada Boulahia, Ghassan Maakaroun, Ghylene Bourdat Michel, Gilbert Zanetta, Gilles Hufnagel, Gilles Messier, Giorgina Piccoli, Gregoire Couvrat Desvergnes, Guillaume Bobrie, Guillaume Bonnard, Guillaume Clement, Guillaume Jean, Guillaume Queffeulou, Guillaume Seret, Guillaume Vernin, Guy Delavaud, Guy Lambrey, Guy Rostoker, Gwenaelle Poussard, Gwenaelle Roussey Kesler, H. Leon, Habib Aboubekr, Hacene Boulechfar, Hacene Sekhri, Hadia Hebibi, Hadjira Benalia, Hafed Fessi, Hafsabhai Atchia, Haiat Bittar, Hakim Maiza, Hakim Mazouz, Hamid El Ali, Hammouche Bougrida, Hans Van Der Pijl, Hassan Lokmane, Hassane Izzedine, Hassen Adda, Helene De Preneuf, Helene Leray, Helene Philippot, Henri Boulanger, Henri Merault, Henri Renaud, Herve Bonarek, Herve Maheut, Hilaire Nzeyimana, Hocine Mehama, Hocine Zaidi, Hugo Weclawiak, Hugues Flodrops, Huseyin Karaaslan, Ibrahim Haskour, Ihssen Belhadj, Imad Almoubarak, Imad Haddad, Ines Castellano, Ines Ferrandiz, Ioana Daniliuc, Ioana Darie, Ioana Enache, Ionut Prunescu, Irenee Djiconkpode, Irina Shahapuni, Isabelle Bouchoule, Isabelle Devriendt, Isabelle Kazes, Isabelle Kolb, Isabelle Landru, Isabelle Poli, Isabelle Rey, Isabelle Segalen, Isabelle Selcer, Isabelle Vernier, Isabelle Vrillon, Ismahane Guenifi, J. Dominique Gheerbrandt, Jacky Potier, Jacques Becart, Jacques Cledes, Jacques Ducros, Jacques Duvic, Jacques Fourcade, Jacques Gaultier, Jacques Jurine, Jacques Lebleu, Jacques Ollier, Jacques Ibsen Charles, Jamal Yazji, Janette Mansour, Jean Arnautou, Jean Brocard, Jean Carolfi, Jean Montoriol, Jean Baptiste Gouin, Jean Bernard Palcoux, Jean Christophe Bendini, Jean Claude Aldigier, Jean Claude Alphonse, Jean Daniel Delbet, Jean Francois Bonne, Jean Francois Cantin, Jean Francois De Fremont, Jean Francois Dessassis, Jean Francois Subra, Jean Francois Valentin, Jean Francois Verdier, Jean Jacques Dion, Jean Jacques Haultier, Jean Jacques Montseny, Jean Louis Bacri, Jean Louis Bouchet, Jean Luc Mahe, Jean Marc Chalopin, Jean Marc Gabriel, Jean Marc Hurot, Jean Marc Lanau, Jean Marie Batho, Jean Marie Coulibaly, Jean Michel Hardin, Jean Michel Marc, Jean Michel Poux, Jean Michel Rebibou, Jean Michel Tivollier, Jean Noel Ottavioli, Jean Paul Faucon, Jean Paul Imiela, Jean Paul Jaulin, Jean Paul Masselot, Jean Paul Ortiz, Jean Philippe Bourdenx, Jean Philippe Devaux, Jean Philippe Hammelin, Jean Pierre Rivory, Jean Pierre Wauquier, Jean Rene Larue, Jean Rene Mondain, Jean Sebastien Borde, Jean Simon Virot, Jean Yves Bosc, Jedjiga Achiche, Jennifer Parasote, Jeremie Diolez, Jerome Harambat, Jerome Potier, Jerome Sampol, Jihad Mustel, Jean Jacques Lefevre, Jocelyne Maurizi, Joel Gamberoni, Joelle Claudeon, Joelle Terzic, Joffrey Rogol, Johnny Sayegh, Jorge Cardozo, Jose Brasseur, Jose Guiserix, Joseph Barsumau, Julie Albaret, Julie Beaume, Julie Sohier Attias, Julien Dehay, Julien Hogan, Julien Journet, Julien Ott, Juliette Baleynaud, Justine Bacchetta, Justine Faucher, Kamel Yousfi, Karim Dardim, Karine Clabault, Karine Moreau, Kedna Thomas, Khaled Sirajedine, Khalil Chedid, Khalil El Kaeoui, Khalil El Karoui, Khedidja Bouachi, Kheira Hue, Khuzama El Nasser, Kodso Akposso, Kristian Kunz, Krzysztof Bijak, Lilia Kihal, L. Rasoloarijaona, Laid Harbouche, Larbi Bencheikh, Larbie Lamriben, Latifa Hanafi, Laura Braun Parvez, Laure Champion, Laure Croze, Laure Eprinchard, Laure Patrier, Laurence Nicolet, Laurence Vrigneaud, Laurent Duflot, Leandre Mackaya, Leila Chenine, Leon Odry, Lili Taghipour Tamiji, Lilia Antri Bouzar, Liliane Ngango Nga Messi, Lionel Le Mouellic, Lise Mandart, Lise Weis, Lise Marie Pouteau, Lora Georgieva, Lorita Vitanova, Lotfi Chalabi, Luc Delvallez, Luc Fromentin, Luc Marty, Luc Monjot, Luciana Spataru, Lucie Bessenay, Lucie Boissinot, Lucie Wajsbrot, Lucien Rakoff, Ludivine Lebourg, Lydie Perez, Lyliane Lafage, Lynda Azzouz, Madeleine Dumoulin, Messaoud Ouziala, Maan Joseph, Mabrouk Brahimi, Maeva Wong Fat, Magalie Fort, Magued Nakhla, Mahdi Abtahi, Mahen Albadawy, Mahmoud Alouach, Mahmoud Mezghani, Maite Daroux, Maklouf Boukelmoune, Malek Dhib, Malik Touam, Malina Dubau, Mamadou Balde, Man Nguyen Khoa, Manfred Ismer, Manolie Mehdi, Manon Laforet, Marc Bouiller, Marc Eugene, Marc Fila, Marc Hazzan, Marc Kribs, Marc Ladriere, Marc Lebot, Marc Padilla, Marc Souid, Marcel Marraoui, Maren Burbach, Maria Manescu, Maria Eugenia Noguera Gonzalez, Mariana Revenco, Marianne Terrasse, Marie Essi, Marie Alice Macher, Marie Beatrice Nogier, Marie Cecile Cazin, Marie Christine Schweitzer Camoin, Marie Christine Thouret, Marie Claude Hannaert, Marie France Servel, Marie Helene Chabannier, Marie Jeanne Coudert Krier, Marie Noelle Catoliquot, Marie Paule Guillodo, Marie Sophie Gavard, Marie Xaviere Vairon Codaccioni, Marina Rabec, Marine Freist, Marion Gauthier, Marion Lemaire, Marion Mehrenberger, Marion Venot, Marios Pongas, Marlene Beaubrun Diant, Martial Levannier, Martine Bertaux, Mathieu Jablonski, Mathieu Sacquepee, Mathilde Dargelos, Mathilde Lemoine, Mathilde Tamain, Matthieu Monge, Matthieu Reberolle, Maud Cousin, Maud Francois, Maurice Baron, Maxime Hoffmann, Maxime Ingwiller, Maxime Touzot, Mederick Mohajer, Mehadji Maaz, Melanie Hanoy, Melanie Marroc, Melodie Cuny, Menno Van Der Straaten, Mf. Serveaux, Michel Basteri, Michel Fen Chong, Michel Hecht, Michel Massad, Michel Normand, Michel Olmer, Michel Tolani, Michel Tsimaratos, Michele Hemery, Michele Kessler, Miguel Esposito, Milad Shenouda, Mimi Kareche, Mina Khalili, Mirella Diaconita, Mohamad Khair Rifard, Mohamed Aladib, Mohamed Belmouaz, Mohamed Brahim, Mohamed Diouani, Mohamed Fodil Cherif, Mohamed Jamali, Mohamed Maghlaoua, Mohamed Meddeb, Mohamed Ramdane, Mohamed Rifaat, Mohamed Sharifull Islam, Mohamed Adnan Abbade, Mokhtar Amrandi, Mokhtar Chawki, Monica Ciobotaru, Monica Indrieis, Monique Chanas, Monique Hoarau, Monzer Tomeh, Moufida Bellou, Mouloud Bouzernidj, Mounia Ammor, Mounir Guergour, Mountassir Benzakour, Mourad Hachicha, Moussa Coulibaly, Mustafa Smati, Mustapha Al Morabiti, Mustapha Amirou, Myriam Isnard, Myriam Pastural, Myriam Pujo, Nourredine Boumendjel, Nabil Majbri, Nabila Goumri, Nadege Mingat, Nader Bassilios, Nadia Kerkeni, Nadia Sedrati, Nadia Soltani, Nadine Maroun, Nadine Neyrat, Nahn Luang, Najeh El Esper, Naji Ammar, Nasredine Ghali, Nasser Hamdini, Natacha Noel, Natacha Potelune, Nathalie Maisonneuve, Nathalie Pertuiset, Nathalie Raynal, Nathalie Vittoz, Nazim Terki, Nelly Castin, Nestor Nankeu, Nicolas Bouvier, Nicolas Keller, Nicolas Legros, Nicolas Peters, Nicolas Quirin, Nicole Lefrancois, Nicole Monnier, Nicole Rance, Niels Bruckmann, Noel Mertens, Nolwenn Lorcy, Olivia Gilbert, Olivier Coldefy, Olivier Drouineau, Olivier Dunand, Olivier Fritz, Olivier Imhoff, Olivier Kourilsky, Olivier Lavelle, Olivier Papin, Olivier Roques, Ophelie Le Maner, Oussamah Fikri Benbrahim, Pablo Antonio Erina Torres, Pablo Antonio Urena Torres, Paolo Malvezzi, Pascal Bindi, Pascal Cluzel, Pascal Fontanier, Pascal Wheatley, Pascale Depraetre, Pascale Dubosq, Pascale Halin, Pascale Sebahoun, Pascale Siohan, Pascale Testevuide, Patrice Deteix, Patrice Nolen, Patricia Hue, Patricia Lemarchand, Patrick Donnadieu, Patrick Fievet, Patrick Fohrer, Patrick Francais, Patrick Giraud, Patrick Hallonet, Patrick Henri, Patrick Michaut, Patrick Niaudet, Patrick Pauly, Patrick Thomas, Patrik Deleaval, Paul Finielz, Paul Stroumza, Paule Hardy Yverneau, Pauline Caillard, Pedro Palacin, Perrine Aubertin, Philippe Attias, Philippe Chauveau, Philippe Coindre, Philippe Coste, Philippe Dubot, Philippe Fournier, Philippe Hiernaux, Philippe Jousset, Philippe Lan Yue Wah, Philippe Lang, Philippe Le Cacheux, Philippe Martin Dupont, Philippe Michel, Philippe Mirgaine, Philippe Moriniere, Philippe Nicoud, Philippe Rieu, Philippe Rousseau, Philippe Sporer, Philippe Thorel, Philippe Vanhille, Philippe Vigeral, Philippe Zaoui, Pierre Bataille, Pierre Brignon, Pierre Filipozzi, Pierre Housset, Pierre Peyronnet, Pierre Ramperez, Pierre Vautrin, Pierre Alexandre Michel, Pierre Francois Westeel, Pierre Louis Carron, Pierre Yves Durand, Pierrot Parent, Piotr Seniuta, François Kuentz, Rabah Fraoui, Rachel Tetaz, Rachid Amaria, Rachid Bourouma, Rachid Djeffal, Rachida Nebbad, Radia Allal, Radu Dimulescu, Rafaat Boustani, Rafik Mesbah, Raifat Makdassi, Raji Diab, Raluca Puslenghea, Raoul Roura, Rateb Khayat, Raymond Azar, Raymond Frayssinet, Regine Monkam, Rehouni Boulahrouz, Remi Boudet, Renato Demontis, Renaud Gansey, Rene Cuvelier, Renee Schmitt, Reschad Noordally, Reynald Binaut, Rezkallah Latif, Richard Dufresne, Richard Montagnac, Richard Reade, Robert Genin, Robert Novo, Rocsana Fickl, Roger Dufresne, Roger Magnol, Roland Issautier, Romain Mortelette, Ronan Delaval, Ronan Lohro, Roseline M'barga, S. Beau, Clémentine Dupuis, Marie Jacques Vidil, Sabria Hacini, Said Dahmoune, Saliha Lekhal, Salima Ahriz Sakso, Salima Saksi, Salvatore Citarda, Samir Boubenider, Samuel Kassis, Sandra Verhille, Sandrine Genestier, Sandrine Muller, Saoussen Krid, Sarah Richter, Sebastien Delbes, Sebastien Mailliez, Sebastien Veillon, Sébastien Nony, Seddick Benarbia, Severine Beaudreuil, Sidi Ali Benyaghla, Simon Duquennoy, Simona Baluta, Simona Boncila, Sonia Mzoughi, Sonia Ribal, Sophie Acamer, Sophie Chauvet, Sophie Girerd, Sophie Ozenne, Sophie Parahy, Sophie Rubens Duval, Sophie Taque, Soraya Menouer, Soumaya Chargui, Stanislas Bataille, Stephane Barbier, Stephane Billion, Stephane Roueff, Stephane Torner, Stephane Jean Martin, Stephanie Coupel, Sylvie Cloarec, Sylvie Lavaud, Sylvie Leou, T. Chatelet, Tania Onesta, Tassadit Benhabib, Tayeb Bensalem, Theodora Dimulescu, Theophile Sawadogo, Thibault Dolley Hitze, Thierry Baranger, Thierry Boudemaghe, Thierry Hannedouche, Thierry Krummel, Thierry Milcent, Thomas Dervaux, Thomas Guincestre, Thomas Kofman, Thomas Raphael, Thomas Sadreux, Tim Ulinski, Tiphaine Guyon Roger, Tomas Serrato, Tomek Kofman, Tony Wong, Toufik Boubia, Ubald Assogba Gbindoun, Usama Khuzaie, Valerie Caudwell, Valerie Chatelet, Valerie Crougneau, Valerie De Precigout, Valerie Drouillat, Valerie Galantine, Valerie Granveau Hugot, Valerie Leroy, Veronique Boubia, Veronique Falque, Veronique Fournier, Veronique Queron, Veronique Viviani, Victor Gueuttin, Victor Panescu, Victorio Menoyo Calonge, Viet Nguyen, Vincent Allot, Vincent Delattre, Vincent Leduc, Vincent Pradier, Violaine Emal Aglae, Viorica Badulescu, Virginia Molina, Virginie Besson, Virginie Chaigne, Waddah Jaber, Wael Boudi, Wael El Haggan, Wen Qin Guillon, Wided Tabbi Aneni, William Hanf, Wladimir Kohn, Xavier Bellenfant, Xavier Moreau Gaudry, Yahsou Delmas, Yannick Knefati, Yannick Saingra, Yannick Tirolien, Youssef Mann, Yvan Brunak, Yves Dimitrov, Yves Doussy, Yves Tanter, Zaid Benabid, Zaara Soltani, Zacharia Boukerroucha, Zafer Takla, Zana Ramanantsialonina, Zara Dickson, Zead Tubail, Zoe Koochaki Pour, Zohra Boukhalfa, Zohra Jacquot, Agence de la biomédecine [Saint-Denis la Plaine], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université de Caen Normandie (UNICAEN), Normandie Université (NU), CALYDIAL Vienne, Partenaires INRAE, Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Armand Trousseau [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy] (Pôle S2R), Centre Universitaire des Maladies Rénales [CHU Caen] (CUMR Caen), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Groupe hospitalier de la région de Mulhouse Sud-Alsace (GHRMSA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Assistance Publique - Hôpitaux de Marseille (APHM), Service de diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Service de Diabétologie [CHU Pitié-Salpétrière], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
0301 basic medicine, Male, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Hemodialysis, Home, Disease, MESH: COVID-19 / therapy, registry, Ambulatory Care Facilities, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, MESH: Aged, 80 and over, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Risk Factors, 80 and over, Prevalence, covid, dialysis, epidemiology, mortality, Aged, Aged, 80 and over, COVID-19, Case-Control Studies, Critical Care, Female, France, Humans, Incidence, Middle Aged, Patient Acuity, Protective Factors, Registries, Renal Dialysis, SARS-CoV-2, Sex Factors, Hypoalbuminemia, MESH: France / epidemiology, education.field_of_study, Incidence (epidemiology), 3. Good health, MESH: COVID-19 / epidemiology, Nephrology, Hemodialysis, medicine.medical_specialty, Population, Lower risk, Article, 03 medical and health sciences, MESH: Sex Factors, Internal medicine, medicine, MESH: SARS-CoV-2, MESH: Renal Dialysis / statistics & numerical data, education, Dialysis, Vascular disease, business.industry, medicine.disease, Former Smoker, MESH: Critical Care / statistics & numerical data, 030104 developmental biology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Home, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MESH: Hemodialysis, Home / statistics & numerical data
Abstract

The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed., Graphical abstract

Published
2020
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37. Cytokine release syndrome‐associated encephalopathy in patients with COVID‐19

Author

Gabriela Gautier-Vargas, Seyyid Baloglu, Sophie Caillard, Bruno Moulin, Nicolas Keller, Dimitri Bedo, Nicolas Collongues, Thomas Lavaux, Ilies Benotmane, Xavier Bassand, Stéphane Kremer, Samira Fafi-Kremer, and Peggy Perrin

Subjects
Male, encephalitis, neurological disorders, Brain Edema, Gastroenterology, corticosteroids, 0302 clinical medicine, Cerebrospinal fluid, Adrenal Cortex Hormones, intravenous immunoglobulin, cytokine, Longitudinal Studies, 030212 general & internal medicine, Brain Diseases, medicine.diagnostic_test, Brain, Middle Aged, Magnetic Resonance Imaging, Cytokine release syndrome, Treatment Outcome, Neurology, Blood-Brain Barrier, Original Article, Female, medicine.symptom, kidney, medicine.medical_specialty, Encephalopathy, Clinical Neurology, Immunoglobulins, intravenous immunoglobulins, 03 medical and health sciences, COVID‐19, Internal medicine, medicine, Humans, Aged, Ischemic Stroke, Coma, Cerebellar ataxia, business.industry, COVID-19, Dysautonomia, cytokine release syndrome, Magnetic resonance imaging, Original Articles, medicine.disease, Uremia, neurological manifestations, Neurology (clinical), Nervous System Diseases, business, 030217 neurology & neurosurgery
Abstract

BACKGROUND AND PURPOSE: Neurological manifestations in coronavirus disease (COVID)-2019 may adversely affect clinical outcomes. Severe COVID-19 and uremia are risk factors for neurological complications. However, the lack of insight into their pathogenesis, particularly with respect to the role of the cytokine release syndrome (CRS), is currently hampering effective therapeutic interventions. The aims of this study were to describe the neurological manifestations of patients with COVID-19 and to gain pathophysiological insights with respect to CRS. METHODS: In this longitudinal study, we performed extensive clinical, laboratory and imaging phenotyping in five patients admitted to our renal unit. RESULTS: Neurological presentation included confusion, tremor, cerebellar ataxia, behavioral alterations, aphasia, pyramidal syndrome, coma, cranial nerve palsy, dysautonomia, and central hypothyroidism. Notably, neurological disturbances were accompanied by laboratory evidence of CRS. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was undetectable in the cerebrospinal fluid (CSF). Hyperalbuminorrachia and increased levels of the astroglial protein S100B were suggestive of blood-brain barrier (BBB) dysfunction. Brain magnetic resonance imaging findings comprised evidence of acute leukoencephalitis (n = 3, one of whom had a hemorrhagic form), cytotoxic edema mimicking ischaemic stroke (n = 1), or normal results (n = 2). Treatment with corticosteroids and/or intravenous immunoglobulins was attempted, resulting in rapid recovery from neurological disturbances in two cases. SARS-CoV2 was undetectable in 88 of the 90 patients with COVID-19 who underwent Reverse Transcription-PCR testing of CSF. CONCLUSIONS: Patients with COVID-19 can develop neurological manifestations that share clinical, laboratory and imaging similarities with those of chimeric antigen receptor T-cell-related encephalopathy. The pathophysiological underpinnings appear to involve CRS, endothelial activation, BBB dysfunction, and immune-mediated mechanisms.

Published
2020
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38. Biomarkers of Cytokine Release Syndrome Predict Disease Severity and Mortality From COVID-19 in Kidney Transplant Recipients

Author

Francoise Heibel, Ilies Benotmane, Samira Fafi Kremer, Thomas Lavaux, Gabriela Gautier Vargas, Clement Baldacini, Mylene Sagnard, Heloise Delagreverie, Jérôme Olagne, David Marx, Bruno Moulin, Sophie Caillard, Mickaël Ohana, Nicolas Keller, Margaux Della Chiesa, Noëlle Cognard, Xavier Bassand, Laura Braun, Dimitri Bedo, Dogan-Firat Bozman, and Peggy Perrin

Subjects
Male, medicine.medical_specialty, Population, 030230 surgery, Severity of Illness Index, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Severity of illness, medicine, Coagulopathy, Humans, education, Kidney transplantation, Aged, education.field_of_study, Transplantation, biology, business.industry, Interleukin-6, SARS-CoV-2, Mortality rate, C-reactive protein, Troponin I, COVID-19, Middle Aged, medicine.disease, Kidney Transplantation, Hospitalization, Cytokine release syndrome, C-Reactive Protein, biology.protein, 030211 gastroenterology & hepatology, Female, business, Cytokine Release Syndrome, Biomarkers, Cohort study
Abstract

BACKGROUND Data on coronavirus disease 2019 (COVID-19) in immunocompromised kidney transplant recipients (KTR) remain scanty. Although markers of inflammation, cardiac injury, and coagulopathy have been previously associated with mortality in the general population of patients with COVID-19, their prognostic impact amongst KTR with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has not been specifically investigated. METHODS We conducted a cohort study of 49 KTR who presented with COVID-19. Clinical and laboratory risk factors for severe disease and mortality were prospectively collected and analyzed with respect to outcomes. The study participants were divided into 3 groups: (1) mild disease manageable in an outpatient setting (n = 8), (2) nonsevere disease requiring hospitalization (n = 21), and (3) severe disease (n = 20). RESULTS Gastrointestinal manifestations were common at diagnosis. The 30-day mortality rate in hospitalized patients was 19.5%. Early elevations of C-reactive protein (>100 mg/L) and interleukin-6 (>65 ng/L) followed by increases in high-sensitivity troponin I (>30 ng/L) and D-dimer (>960 ng/mL) were significantly associated with severe disease and mortality. Viral load did not have prognostic significance in our sample, suggesting that outcomes were chiefly driven by a cytokine release syndrome (CRS). CONCLUSIONS Regular monitoring of CRS biomarkers in KTR with COVID-19 is paramount to improve clinical outcomes.

Published
2020
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39. Antibacterial and Biofilm-Preventive Photocatalytic Activity and Mechanisms on P/F-Modified TiO 2 Coatings

Author

Valérie Keller, Nicolas Keller, Lydie Ploux, Yige Yan, Charline Soraru, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], photocatalytic activity, Biomedical Engineering, mechanism, Pseudomonas fluorescens, 02 engineering and technology, engineering.material, medicine.disease_cause, Bacterial cell structure, Biomaterials, surface topographic properties, 03 medical and health sciences, Coating, Staphylococcus epidermidis, medicine, [CHIM]Chemical Sciences, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Escherichia coli, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, immediate versus long-term biofilm-preventive activity, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, biology, Biochemistry (medical), Biofilm, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, 021001 nanoscience & nanotechnology, biology.organism_classification, Antibacterial P/F-modified TiO2 coating, chemistry, engineering, 0210 nano-technology, Bacteria, Nuclear chemistry
Abstract

International audience; Photocatalytic antibacterial and biofilm-preventive activity in liquid of heavy-metal-free coatings based on a phosphorus (P) and fluorine (F)-modified TiO2 photocatalyst has been investigated. They reveal significantly higher immediate and longer-term (biofilm-preventive) inactivation capacity than a reference coating made of the commercial photocatalyst TiO2 P25 on three bacterial species differing in cell wall type and ability to resist oxidative stress (Escherichia coli, Staphylococcus epidermidis, Pseudomonas fluorescens) (up to more than 99% reduction of colonization on P/F-modified TiO2 coating compared to about 50% on P25 TiO2 coating for 10 min UV-A illumination). This results from the P-and F-induced improvement of photocatalyst properties and from the smoother surface topography, which shortens reactive oxygen species (ROSs) diffusion to the outer membrane of the targeted adhered bacteria. Decrease in ROSsrelated impairment of cell wall, respiratory and enzymatic activities confirms the loss of ROSs throughout the bacterial cell degradation. Staphylococcus epidermidis and Pseudomonas fluorescens are less sensitive than Escherichia coli, with a probable relation to the bacterial oxygen stress defense mechanism. The coating antibacterial efficacy was highly affected by phosphate ions and the richness in dissolved oxygen of the reaction medium.

Published
2020
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40. Efficient photocatalytic mineralization of polymethylmethacrylate and polystyrene nanoplastics by TiO2/β-SiC alveolar foams

Author

Paul Henri Allé, Kopoin Adouby, Patricia García-Muñoz, Didier Robert, Nicolas Keller, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Microplastics, Materials science, Nanoparticle, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, chemistry.chemical_compound, Environmental Chemistry, Polystyrene, 0105 earth and related environmental sciences, β-SiC, Pollutant, nanoplastic, Mineralization (soil science), water treatment, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, polymethylmethacrylate, 6. Clean water, Volumetric flow rate, Light intensity, chemistry, Chemical engineering, 13. Climate action, Photocatalysis, 0210 nano-technology, photocatalysis
Abstract

International audience; Many household wastewaters contain Microplastics (MPs) and nanoplastics (NPs). Most of this type of pollution is not stopped by current wastewater treatment plants provoking their entrance into the global aquatic systems. This is an emerging issue and potential threat to marine life and human health. However, advanced technologies for efficient MPs and NPs control and elimination remain largely underdeveloped. Heterogeneous photocatalysis represents an attractive and efficient decomposition technique for the nanoplastic particle degradation. The first objectives of this work were i) to study the feasibility of nanoplastic degradation by photocatalysis and ii) to determine the influence of certain reaction parameters i.e. the flowrate, the pH0 and the light intensity on the photocatalytic degradation of calibrated polymethylmethacrylate (PMMA) and polystyrene (PS) nanoparticles with TiO2-P25/β-SiC foams under UV-A. The first results are very encouraging, because to our knowledge, we are the first to show that it is possible to mineralize PMMA and PS nanobeads 2 by UV-A photocatalysis. We were able to convert in 7 hours, 50% of an aqueous suspension loaded with PMMA nanobeads (TOC = 12 mg/l) by working at an irradiance of 112 W/m 2 , with a flowrate of 10 mL/min and at initial pH value of 6.3, using TiO2-P25/β-SiC foams in a flow-through mode. We also showed that the photocatalytic treatment can be applied to various polymers, such as polystyrene and PMMA.

Published
2020
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41. Ni-Pd/γ-Al2O3 Catalysts in the Hydrogenation of Levulinic Acid and Hydroxymethylfurfural towards Value Added Chemicals

Author

Nicolas Keller, Marcin Jędrzejczyk, Emilia Soszka, Agnieszka M. Ruppert, Ireneusz Kocemba, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
formic acid, Formic acid, Astrophysics::High Energy Astrophysical Phenomena, Inorganic chemistry, hydroxymethylfurfural, levulinic acid, 010402 general chemistry, lcsh:Chemical technology, 7. Clean energy, 01 natural sciences, Catalysis, lcsh:Chemistry, γ-valerolactone, chemistry.chemical_compound, Levulinic acid, 5-bis(hydroxymethyl)-tetrahydrofuran, Hydroxymethyl, lcsh:TP1-1185, Physical and Theoretical Chemistry, Bimetallic strip, 010405 organic chemistry, selectivity, [CHIM.CATA]Chemical Sciences/Catalysis, 3. Good health, 0104 chemical sciences, chemistry, lcsh:QD1-999, g-Al2O3 supported Ni-Pd catalysts, γ-Al2O3 supported Ni-Pd catalysts, 2,5-bis(hydroxymethyl)-tetrahydrofuran, Selectivity, Hydrodeoxygenation, Hydroxymethylfurfural
Abstract

&gamma, Al2O3 supported Ni-Pd catalysts with different Ni:Pd ratios were studied in the hydrogenation of two industrially-relevant platform molecules derived from biomass, namely levulinic acid and hydroxymethylfurfural. The bimetallic catalysts showed better performances in both processes in comparison to the monometallic counterparts, for which a too strong interaction with the alumina support reduced the activity. The behavior of the bimetallic catalysts was dependent on the Ni:Pd ratio, and interestingly also on the targeted hydrogenation reaction. The Pd-modified Ni-rich system behaves like pure Ni catalyst, but with a strongly boosted activity due to a higher number of Ni active sites available, Pd being considered as a spectator. This high activity was manifested in the levulinic acid hydrogenation with formic acid used as an internal hydrogen source. This behavior differs from the case of the Pd-rich system modified by Ni, which displayed a much higher Pd dispersion on the support compared to the monometallic Pd catalyst. The higher availability of the Pd active sites while maintaining a high surface acidity allows the catalyst to push the HMF hydrodeoxygenation reaction forward towards the green biopolymer precursor 2,5-bis(hydroxymethyl)-tetrahydrofuran, and in consequence to strongly modify the selectivity of the reaction. In that case, residual chlorine was proposed to play a significant role, while Ni was considered as a spectator.

Published
2020
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42. Solvothermal hydrodeoxygenation of hydroxymethylfurfural derived from biomass towards added value chemicals on Ni/TiO2 catalysts

Author

Martyna Przydacz, Magdalena Brzezińska, Agnieszka M. Ruppert, Nicolas Keller, Marcin Jędrzejczyk, Jacek Rogowski, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Matériaux, Surfaces et Procédés pour la Catalyse (LMSPC), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE)

Subjects
Ni/TiO2, hydrothermally prepared titania, Commodity chemicals, General Chemical Engineering, chemistry.chemical_element, Nanoparticle, Biomass, Lignocellulosic biomass, 02 engineering and technology, hydrodeoxygenation, 010402 general chemistry, 01 natural sciences, 7. Clean energy, Catalysis, DMF, chemistry.chemical_compound, Physical and Theoretical Chemistry, HMF, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Nickel, chemistry, Chemical engineering, 0210 nano-technology, [CHIM.OTHE]Chemical Sciences/Other, Hydrodeoxygenation, Hydroxymethylfurfural
Abstract

International audience; Lignocellulosic biomass is one of the most abundant renewable source of commodity chemicals like hydroxymethylfurfural. Solvothermal hydrodeoxygenation of hydroxymethylfurfural towards value added chemicals was performed with a series of nickel based catalysts supported on different titania materials, ie. hydrothermally-prepared high aspect ratio and commercial TiO2 with different morphologies and crystallographic structures. The kind of titania strongly influenced the properties of the supported nickel nanoparticles, which allowed to tune the reaction selectivity towards specific products. Rutile-containing titania forced stronger Ni-Ti interaction, enhanced hydrogen adsorption, and formed larger Ni particles which resulted in high activity. Hydrothermally-prepared materials allowed to obtain selectively 2,5-bishydroxymethyltetrahydrofuran (biopolymer precursor) due a relatively small surface acidity and large Ni particles. By contrast, large surface area anatase with small nickel particles and small surface acidity allowed to selectively obtain 2,5-dimethylfuran (biofuel additive).

Published
2020
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43. Rapid resolution of cytokine release syndrome and favorable clinical course of severe COVID-19 in a kidney transplant recipient treated with tocilizumab

Author

Ilies Benotmane, Gabriela Gautier-Vargas, Sophie Caillard, Peggy Perrin, Clement Baldacini, Bruno Moulin, and Nicolas Keller

Subjects
2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical course, medicine.disease, Gastroenterology, Kidney transplant recipient, chemistry.chemical_compound, Cytokine release syndrome, Tocilizumab, chemistry, Nephrology, Internal medicine, medicine, business, Kidney transplantation
Published
2020
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44. Understanding the influence of the composition of the Ag- Pd catalysts on the selective formic acid decomposition and subsequent levulinic acid hydrogenation

Author

Marcin Jędrzejczyk, Olga Sneka-Płatek, Carine Michel, Nicolas Keller, Philippe Sautet, Agnieszka M. Ruppert, Kamila Kaźmierczak, Łódź University of Technology, Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), University of California [Los Angeles] (UCLA), University of California, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of California (UC), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA), Michel, Carine, and École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
formic acid, Formic acid, Energy Engineering and Power Technology, Context (language use), 02 engineering and technology, levulinic acid, 010402 general chemistry, 01 natural sciences, 7. Clean energy, Catalysis, Hydrolysis, chemistry.chemical_compound, Adsorption, Levulinic acid, hydrogen transfer, ComputingMilieux_MISCELLANEOUS, biomass, Renewable Energy, Sustainability and the Environment, Chemistry, [CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Decomposition, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry, Fuel Technology, Ag-Pd catalysts, DFT study, 0210 nano-technology, Selectivity, Nuclear chemistry
Abstract

International audience; Formic acid is obtained in equimolar amount with levulinic acid during the hydrolysis of cellulose and thus can be used as a sustainable hydrogen source in the direct levulinic acid hydrogenation towards gamma-valerolactone (biofuel additive). Ag-Pd catalysts prepared by various methods and containing different Ag:Pd ratio were investigated in this context. By combining activity tests, characterization of the main physicochemical properties of the catalysts and DFT study of formic acid decomposition, the key factors responsible for the activity of Ag-Pd catalysts in both the formic acid decomposition and the subsequent hydrogenation of levulinic acid were specified. Pd is shown to be active, but prone to poisoning by CO, while the CO poisoning remains limited on diluted Ag-Pd alloy with strong intermetallic interaction, where its adsorption is very weak thanks to the isolation of Pd atoms. Therefore, the catalyst containing 4%Ag-1%Pd/AlOOH showed the highest selectivity in formic acid decomposition as well as the highest activity in levulinic acid hydrogenation (34% conversion in 5 h at 190°C).

Published
2020
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45. Cytokine Release Syndrome-Associated Encephalopathy in Patients with COVID-19

Author

Thomas Lavaux, Ilies Benotmane, Dimitri Bedo, Samira Fafi-Kremer, Nicolas Keller, Gabriela Gautier, B. Moulin, Peggy Perrin, Stéphane Kremer, Seyyid Baloglu, Nicolas Collongues, Sophie Caillard, and Xavier Bassand

Subjects
Coronavirus disease 2019 (COVID-19), business.industry, medicine.medical_treatment, clinical_neurology, Encephalopathy, medicine.disease, Pathophysiology, Cytokine release syndrome, Cytokine, Intravenous Immunoglobulins, Immunology, Medicine, In patient, business, Kidney disease
Abstract

Severe disease and uremia are risk factors for neurological complications of coronavirus disease-2019 (COVID-19). An in-depth analysis of a case series was conducted to describe the neurological manifestations of patients with COVID-19 and gain pathophysiological insights that may guide clinical decision-making – especially with respect to the cytokine release syndrome (CRS). Extensive clinical, laboratory, and imaging phenotyping was performed in five patients. Neurological presentation included confusion, tremor, cerebellar ataxia, behavioral alterations, aphasia, pyramidal syndrome, coma, cranial nerve palsy, dysautonomia, and central hypothyroidism. Neurological disturbances were remarkably accompanied by laboratory evidence of CRS. SARS-CoV-2 was undetectable in the cerebrospinal fluid. Hyperalbuminorachy and increased levels of the astroglial protein S100B were suggestive of blood-brain barrier (BBB) dysfunction. Brain MRI findings comprised evidence of acute leukoencephalitis (n = 3, of whom one with a hemorrhagic form), cytotoxic edema mimicking ischemic stroke (n = 1), or normal results (n = 2). Treatment with corticosteroids and/or intravenous immunoglobulins was attempted – resulting in rapid recovery from neurological disturbances in two cases. Patients with COVID-19 can develop neurological manifestations that share clinical, laboratory, and imaging similarities with those of chimeric antigen receptor-T cell-related encephalopathy. The pathophysiological underpinnings appear to involve CRS, endothelial activation, BBB dysfunction, and immune-mediated mechanisms.

Published
2020

47. Photocatalytic Degradation of Myclobutanil and Its Commercial Formulation with TiO₂ P25 in Slurry and TiO₂

Author

Ignace Christian, M'Bra, Didier, Robert, Nicolas, Keller, Patrick, Drogui, and Albert, Trokourey

Abstract

Viticulture is one of the crops most subject to pest control by fungicides. Their drainage towards the fresh water affects the aquatic environment, the fauna, the flora and especially the human health. It is therefore necessary to find an adequate solution to solve this problem. Heterogeneous photocatalysis is an advanced oxidation method for the degradation and mineralization of organic pollutants in water and air using semi-conductor (e.g., TiO²). TiO₂ P25 in suspension (0.75 g·L

Published
2020

48. Synergy effect between photocatalysis and heterogeneous photo-Fenton catalysis on Ti-doped LaFeO 3 perovskite for high efficiency light-assisted water treatment

Author

Fernando Fresno, Didier Robert, Patricia García-Muñoz, Christophe Lefevre, Nicolas Keller, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
inorganic chemicals, Materials science, Doping, 02 engineering and technology, Mineralization (soil science), [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 7. Clean energy, 01 natural sciences, Catalysis, 0104 chemical sciences, Reaction rate, Chemical engineering, Yield (chemistry), Photocatalysis, [CHIM]Chemical Sciences, Water treatment, 0210 nano-technology, Perovskite (structure)
Abstract

International audience; A strategy combining both heterogenized photo-Fenton and photocatalysis advanced oxidation processes in a single dual catalyst is developed for simultaneously benefiting from the higher reaction rate of photo-Fenton and the higher mineralization yield of photocatalysis in water treatment, while overcoming the strong drawbacks still limiting their viability as single processes. We prepared via a facile Pechini sol-gel route a highly efficient and stable Ti-substituted LaFeO3 dual catalyst, active simultaneously as reusable photo-Fenton solid catalyst and photocatalyst in water treatment. The partial substitution of La by Ti ions in the crystalline network led to pure heterogeneous surface reactions with an increase in the catalyst robustness by more than two orders of magnitude, symbolized by the absence of any Fe release and the stability of catalytic performance with test cycles. It further strongly enhanced the reaction rates, due to both an increased availability of the photogenerated charge carriers at the surface and the electronic enrichment of surface Fe, and allowed full mineralization of the pollutant to be achieved at circumneutral pH through combined advanced oxidation processes.

Published
2020
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49. Quelles cibles tensionnelles dans la maladie rénale chronique non diabétique ?

Author

Thierry Krummel, Nicolas Keller, Thierry Hannedouche, and Eric Prinz

Subjects
medicine.medical_specialty, business.industry, Disease, 030204 cardiovascular system & hematology, medicine.disease, Optimal management, 03 medical and health sciences, 0302 clinical medicine, Blood pressure, Cardiovascular prevention, Nephrology, Medicine, In patient, 030212 general & internal medicine, Risk factor, business, Intensive care medicine, Kidney disease
Abstract

High blood pressure during renal disease is highly prevalent and an important risk factor for cardiovascular disease and renal progression. Its optimal management is therefore necessary to improve the prognosis of patients. Several trials concerning the blood pressure target in patients with chronic non-diabetic kidney disease have been published in recent years, we will detail them in this article in order to determine which blood pressure target provides the best benefit in terms of progression of renal diseases and cardiovascular prevention.

Published
2018
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50. On the role of BmimPF6 and P/F- containing additives in the sol-gel synthesis of TiO2 photocatalysts with enhanced activity in the gas phase degradation of methyl ethyl ketone

Author

Valérie Keller, Nicolas Keller, Yige Yan, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Matériaux, Surfaces et Procédés pour la Catalyse (LMSPC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Keller, Nicolas, Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE)

Subjects
02 engineering and technology, 010402 general chemistry, 01 natural sciences, Catalysis, chemistry.chemical_compound, Hydrolysis, Adsorption, Specific surface area, [CHIM] Chemical Sciences, Sodium fluoride, TiO2, [CHIM]Chemical Sciences, Photocatalysis, synthesis mechanism, Phosphoric acid, ionic liquid, General Environmental Science, [CHIM.MATE] Chemical Sciences/Material chemistry, Process Chemistry and Technology, [CHIM.CATA] Chemical Sciences/Catalysis, sol-gel synthesis, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Phosphate, 0104 chemical sciences, chemistry, Ionic liquid, 0210 nano-technology, Fluoride, Nuclear chemistry
Abstract

International audience; The role of phosphate and fluoride ions brought by the BmimPF6 ionic liquid via hydrolysis during the sol gel synthesis of TiO2 has been investigated by replacing BmimPF6 with phosphorous-and fluorine-containing additives, phosphoric acid (PA) and sodium fluoride (NaF), respectively. Correlation between the physico-chemical properties and the photocatalytic behavior of the synthesized TiO2 materials was established. High crystallinity anatase TiO2 photocatalysts with controlled crystallite size and shape resulting from P/Finduced modifications displayed strongly improved photocatalytic activity and mineralization yield under UV-A illumination in the degradation of methyl ethyl ketone (MEK) taken as model Volatile Organic Compound (VOC), compared to the TiO2 Aeroxide P25 reference and sol-gel TiO2 counterpart synthesized in absence of any BmimPF6. We showed that the BmimPF6 ionic liquid could be efficiently substituted by cheap PA and NaF additives in an adequate ratio in the sol-gel synthesis for synthesizing TiO2 photocatalysts without altering 2 the main physico-chemical properties and the photocatalytic activity. We proposed a similar synthesis mechanism in both ionic liquid-and P/F-assisted sol-gel syntheses of TiO2, involving a combined role of phosphate and fluoride ions. The reaction of phosphates with titanium hydroxide network in the early stage of the sol-gel synthesis resulted in a size control of TiO2 crystallites and thus in higher specific surface area, in favor of a higher MEK conversion rate, while the fluoride ions were hypothesized to cause an anisotropic TiO2 crystal growth during the aging step of the sol gel synthesis, in favor of a higher selectivity to CO2 through a favored adsorption of intermediate products of MEK degradation on the exposed TiO2 {001} facets.

Published
2018
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