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1. IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF

Author

Camilla Cerutti, Serena Lucotti, Sofia T. Menendez, Nicolas Reymond, Ritu Garg, Ignacio A. Romero, Ruth Muschel, and Anne J. Ridley

Subjects
CP: Cancer, Biology (General), QH301-705.5
Abstract

Summary: Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to metastatic outgrowth. Breast and prostate cancers are common malignancies in women and men, respectively. Here, we observe that β1-integrin is required for human prostate and breast cancer cell adhesion to ECs under shear-stress conditions in vitro and to lung blood vessel ECs in vivo. We identify IQGAP1 and neural Wiskott-Aldrich syndrome protein (NWASP) as regulators of β1-integrin transcription and protein expression in prostate and breast cancer cells. IQGAP1 and NWASP depletion in cancer cells decreases adhesion to ECs in vitro and retention in the lung vasculature and metastatic lung nodule formation in vivo. Mechanistically, NWASP and IQGAP1 act downstream of Cdc42 to increase β1-integrin expression both via extracellular signal-regulated kinase (ERK)/focal adhesion kinase signaling at the protein level and by myocardin-related transcription factor/serum response factor (SRF) transcriptionally. Our results identify IQGAP1 and NWASP as potential therapeutic targets to reduce early metastatic dissemination.

Published
2024
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2. TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

Author

Clément Chevalier, Guillaume Collin, Simon Descamps, Heiani Touaitahuata, Valérie Simon, Nicolas Reymond, Laurent Fernandez, Pierre-Emmanuel Milhiet, Virginie Georget, Serge Urbach, Laurence Lasorsa, Béatrice Orsetti, Florence Boissière-Michot, Evelyne Lopez-Crapez, Charles Theillet, Serge Roche, and Christine Benistant

Subjects
Science
Abstract

ERBB2 overexpression in human breast cancer leads to invasion and metastasis. Here the authors report that ERBB2 induces indirect phosphorylation of TOM1L1 that promotes trafficking of the metalloprotease MT1-MMP to invadopodia, which leads to tumour cell invasion.

Published
2016
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3. Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration.

Author

Elisabeth Devilard, Luc Xerri, Patrice Dubreuil, Marc Lopez, and Nicolas Reymond

Subjects
Medicine, Science
Abstract

Lymphocyte trafficking and migration through vascular endothelial cells (ECs) in secondary lymphoid tissues is critical for immune protection. In the present study, we investigate the role of nectin cell adhesion molecules for the migration of lymphocytes through ECs. Nectins are key players for the establishment of homotypic and heterotypic cell to cell contacts; they are required for cell to cell adherens junction formation and take part in the transendothelial migration of monocytes during the step of diapedesis, when monocytes migrate through EC junctions. We first show that Nectin-3 (CD113) is the only nectin expressed by T lymphocytes and since nectins are expressed on ECs we explored Nectin-3 potential functions in lymphocyte: EC interactions. We demonstrate that Nectin-2, expressed on ECs, is the major counter-receptor of Nectin-3. A soluble form of Nectin-3 binds to Nectin-2 localized at EC junctions and blocking Nectin-2 trans-interactions with monoclonal antibodies abolishes the binding of soluble Nectin-3 to ECs. Nectin-2 is expressed on High Endothelial venules (HEVs), where lymphocyte homing occurs in vivo. Finally, we show that Nectin-3 trans-interaction with Nectin-2 is essential for the process of lymphocyte transendothelial migration in vitro as targeting with blocking monoclonal antibodies either Nectin-3, expressed on lymphocytes, or Nectin-2, expressed on ECs, inhibits lymphocyte extravasation. The nectin family of CAMs is important for the regulation of endothelial barrier functions and transendothelial migration of immune cells. Our results demonstrate for the first time that Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation.

Published
2013
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4. RhoB regulates cell migration through altered focal adhesion dynamics

Author

Francisco M. Vega, Audrey Colomba, Nicolas Reymond, Mairian Thomas, and Anne J. Ridley

Subjects
rho guanosine triphosphate, cytoskeleton, rhob, focal adhesions, integrins, rac1, Biology (General), QH301-705.5
Abstract

The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active membrane ruffling around the periphery. Depletion of the exchange factor GEF-H1 induces a similar phenotype. RhoB-depleted cells migrate faster, but less persistently in a chemotactic gradient, and frequently round up during migration. RhoB-depleted cells have similar numbers of focal adhesions to control cells during spreading and migration, but show more diffuse and patchy contact with the substratum. They have lower levels of surface β1 integrin, and β1 integrin activity is reduced in actin-rich protrusions. We propose that RhoB contributes to directional cell migration by regulating β1 integrin surface levels and activity, thereby stabilizing lamellipodial protrusions.

Published
2012
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7. La validité d’une expertise en procédure administrative fédérale

Author

Nicolas Reymond and Ella Volz

Abstract

This contribution focuses on the conditions on the material and formal validity of expert opinions in federal administrative law. It suggests ways of ensuring that the expert opinion complies with the law and how it can be used in the event of divergent opinions. Indeed, it is up to the authority to determine whether or not the expert opinion should be supplemented or even rejected.

Published
2022
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12. TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

Author

Béatrice Orsetti, Virginie Georget, Christine Benistant, Guillaume Collin, Heiani Touaitahuata, Laurent Fernandez, Charles Theillet, Simon Descamps, Pierre-Emmanuel Milhiet, Florence Boissière-Michot, Evelyne Lopez-Crapez, Serge Roche, Clément Chevalier, Nicolas Reymond, Serge Urbach, Laurence Lasorsa, Valérie Simon, Centre de recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre de Microscopie de Rennes (MRic), Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de Biochimie Structurale [Montpellier] (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle (IGF), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire d'anatomo-pathologie, CRLCC Val d'Aurelle - Paul Lamarque, Département d'oncologie Médicale, Ligue Nationale Contre le Cancer - Paris, Ligue Nationale Contre le Cancer (LNCC), Jonchère, Laurent, Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Ligue Nationnale Contre le Cancer, Centre de recherches de biochimie macromoléculaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-IFR122-Centre National de la Recherche Scientifique (CNRS), and CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
0301 basic medicine, Receptor, ErbB-2, [SDV]Life Sciences [q-bio], Science, Endocytic cycle, General Physics and Astronomy, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, macromolecular substances, Biology, General Biochemistry, Genetics and Molecular Biology, SH3 domain, Article, 03 medical and health sciences, Mice, Downregulation and upregulation, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cell Line, Tumor, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Matrix Metalloproteinase 14, Animals, Humans, Neoplasm Invasiveness, skin and connective tissue diseases, neoplasms, Adaptor Proteins, Signal Transducing, Cancer, Multidisciplinary, TOLLIP, Carcinoma, Ductal, Breast, Intracellular Signaling Peptides and Proteins, General Chemistry, 3T3 Cells, Cell Biology, 3. Good health, Cell biology, Biological sciences, 030104 developmental biology, Invadopodia, Phosphorylation, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Female, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src
Abstract

ERBB2 overexpression in human breast cancer leads to invasive carcinoma but the mechanism is not clearly understood. Here we report that TOM1L1 is co-amplified with ERBB2 and defines a subgroup of HER2+/ER+ tumours with early metastatic relapse. TOM1L1 encodes a GAT domain-containing trafficking protein and is a SRC substrate that negatively regulates tyrosine kinase signalling. We demonstrate that TOM1L1 upregulation enhances the invasiveness of ERBB2-transformed cells. This pro-tumoural function does not involve SRC, but implicates membrane-bound membrane-type 1 MMP (MT1-MMP)-dependent activation of invadopodia, membrane protrusions specialized in extracellular matrix degradation. Mechanistically, ERBB2 elicits the indirect phosphorylation of TOM1L1 on Ser321. The phosphorylation event promotes GAT-dependent association of TOM1L1 with the sorting protein TOLLIP and trafficking of the metalloprotease MT1-MMP from endocytic compartments to invadopodia for tumour cell invasion. Collectively, these results show that TOM1L1 is an important element of an ERBB2-driven proteolytic invasive programme and that TOM1L1 amplification potentially enhances the metastatic progression of ERBB2-positive breast cancers., ERBB2 overexpression in human breast cancer leads to invasion and metastasis. Here the authors report that ERBB2 induces indirect phosphorylation of TOM1L1 that promotes trafficking of the metalloprotease MT1-MMP to invadopodia, which leads to tumour cell invasion.

Published
2016
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14. Nectines et nectines-like

Author

Nicolas Reymond, Gaëlle Fournier, Sarah Garrido-Urbani, and Marc Lopez

Subjects
Virus genetics, Tumor suppressor gene, Cell adhesion molecule, Cancer, General Medicine, Biology, medicine.disease_cause, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Herpes simplex virus, Nectin, Cancer research, medicine, Immunoglobulin superfamily, Carcinogenesis
Abstract

Nectin and nectin-like (necl) proteins form a family of 9 adhesion molecules that belong to the immunoglobulin superfamily. They play a key role in different biological processes such as cell polarity, proliferation, differentiation and migration in epithelial, endothelial, immune and nervous systems. Besides their role in physiology, they have been involved in different pathological processes in humans. They serve as virus receptors (poliovirus and herpes simplex virus), they are involved in orofacial malformation (CLPED1) and recently they have been described as markers, actors and potential therapeutics targets in cancer. Among them, necl-5, nectin-2 and nectin-4 are overexpressed in tumors, and are associated with a poor prognosis. On the opposite, necl-1, necl-2 and necl-4 act as tumor suppressors and are repressed in cancer. The involvement of nectins and necls molecules in cancer and their potential used in therapy is discussed in this review.

Published
2010
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16. Prominent Role of the Ig-like V Domain intrans-Interactions of Nectins

Author

Stéphanie Fabre, Francesca Cocchi, Nicolas Reymond, Laura Menotti, Marc Lopez, Gabriella Campadelli-Fiume, and Patrice Dubreuil

Subjects
Adherens junction, Protein structure, Ectodomain, Nectin, Cell adhesion molecule, Immunoglobulin superfamily, Cell Biology, Plasma protein binding, Biology, Molecular Biology, Biochemistry, Molecular biology, Poliovirus Receptor
Abstract

Nectins form a family of integral molecules that belong to the immunoglobulin superfamily. Their ectodomain is made of three Ig-like domains (V, C, C). This family comprises at least five members, namely nectin1, -2, -3, -4, and poliovirus receptor (PVR), that are involved in different physiological and pathological processes. (i) Nectins are adhesion molecules localized at adherens junctions in epithelial cells. (ii) Some nectins act as poliovirus or alpha-herpesvirus receptors (nectin1). (iii) Nectin1 mutations are involved in orofacial developmental abnormalities in humans. Adhesion properties of nectins are mediated by Ca(2+)-independent homophilic and heterophilic processes through ectodomain trans-interactions. We have described a nectin trans-hetero-interaction network: nectin3 binds to nectin1, nectin2, and PVR; nectin1 also binds to nectin4. In the present study we compared the affinities of the different trans-interactions mediated by nectin1. We found that the K(D) of nectin1/nectin3 and nectin1/nectin4 interactions is 1 and 100 nm, respectively, whereas the K(D) of the nectin1-mediated homophilic interaction is 1 microm. We show that nectin1/nectin3 and nectin1/nectin4 trans-hetero-interactions were mediated through trans V to V domain interactions, whereas C domains contributed to increase the affinity of the interaction. Nectin3 and nectin4 share a common binding region in the nectin1 V domain: (i) nectin3 strongly competed with nectin4 binding, (ii) nectin3 and nectin4 binding to nectin1 was reduced by a number of monoclonal antibodies directed against the nectin1 V domain, and (iii) the glycoprotein D of herpes simplex virus-1 that binds to the V domain of nectin1 reduced nectin3 and nectin4 binding. Finally, using chimeric nectin1/PVR receptors where PVR V domain beta-strands were substituted with the corresponding regions of nectin1, the nectin3 and nectin4 minimal binding region on nectin1 V domain was mapped to the C-C'-C"-D beta-strands.

Published
2002
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17. The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction

Author

Francisco M, Vega, Mairian, Thomas, Nicolas, Reymond, and Anne J, Ridley

Subjects
Male, Prostate cancer, Tumor Suppressor Proteins, Research, Prostatic Neoplasms, Epithelial Cells, Adherens Junctions, Cell Communication, RhoB, Cadherins, Gene Expression Regulation, Neoplastic, Cell Line, Tumor, Rho GTPases, Humans, rhoB GTP-Binding Protein
Abstract

Background The Rho GTPase RhoB has been proposed to be a tumor suppressor in cancer and is downregulated in various tumors including prostate. RhoB has different effects on cell migration depending on the cell type and conditions, but the molecular basis for this variability is unclear. RhoB regulates trafficking of membrane receptors and integrins. We have previously shown that RhoB depletion alters focal adhesion dynamics and reduces surface levels of β1 integrin in PC3 prostate cancer cells, correlating with increased migration speed. Results Here we show that RhoB depletion reduces cell-cell adhesion and downregulates E-cadherin levels as well as increasing internalized E-cadherin in DU145 prostate cancer cells. This is accompanied by increased migration speed. RhoB localizes to cell-cell junctions together with E-cadherin in DU145 cells. RhoB depletion also reduces N-cadherin levels in PC3 cells, which do not express E-cadherin. Conclusions These results indicate that RhoB alters migration of cells with cell-cell adhesions by regulating cadherin levels. We propose that the relative contribution of integrins and cadherins to cell migration underlies the variable involvement for RhoB in this process and that the downregulation of RhoB in some epithelial cancers could contribute to the weakening of epithelial cell-cell junction during tumor progression. Electronic supplementary material The online version of this article (doi:10.1186/s12964-015-0085-y) contains supplementary material, which is available to authorized users.

Published
2014

18. RhoC and ROCKs regulate cancer cell interactions with endothelial cells

Author

Nicolas, Reymond, Jae Hong, Im, Ritu, Garg, Susan, Cox, Magali, Soyer, Philippe, Riou, Audrey, Colomba, Ruth J, Muschel, and Anne J, Ridley

Subjects
rho GTP-Binding Proteins, rho-Associated Kinases, cell migration, Endothelial cells, Cell Communication, RhoC, ROCKs, rhoC GTP-Binding Protein, Cell Line, Tumor, Neoplasms, cancer metastasis, Rho GTPases, Human Umbilical Vein Endothelial Cells, Humans, Research Articles, Research Article
Abstract

RhoC is a member of the Rho GTPase family that is implicated in cancer progression by stimulating cancer cell invasiveness. Here we report that RhoC regulates the interaction of cancer cells with vascular endothelial cells (ECs), a crucial step in the metastatic process. RhoC depletion by RNAi reduces PC3 prostate cancer cell adhesion to ECs, intercalation between ECs as well as transendothelial migration in vitro. Depletion of the kinases ROCK1 and ROCK2, two known RhoC downstream effectors, similarly decreases cancer interaction with ECs. RhoC also regulates the extension of protrusions made by cancer cells on vascular ECs in vivo. Transient RhoC depletion is sufficient to reduce both early PC3 cell retention in the lungs and experimental metastasis formation in vivo. Our results indicate RhoC plays a central role in cancer cell interaction with vascular ECs, which is a critical event for cancer progression., Highlights RhoC acts in cancer cells to mediate their interaction with endothelial cells in vitro and in vivo.RhoC regulates cancer cell attachment to and insertion between endothelial cells prior to transendothelial migration.The RhoC effectors ROCK1 and ROCK2 act similarly to regulate cancer cell interaction with endothelial cells.Transient RhoC depletion is sufficient to reduce cancer cell survival in lung blood vessels and metastasis formation.

Published
2014

19. Nectin4/PRR4, a New Afadin-associated Member of the Nectin Family That Trans-interacts with Nectin1/PRR1 through V Domain Interaction

Author

Eric Lecocq, Marc Lopez, José Adélaïde, Patrice Dubreuil, Stéphanie Fabre, and Nicolas Reymond

Subjects
Time Factors, Placenta, Kinesins, Ligands, Biochemistry, Mice, Tissue Distribution, CD155, Cloning, Molecular, Cell adhesion molecule, Microfilament Proteins, Exons, Immunohistochemistry, Ectodomain, COS Cells, Receptors, Virus, Poliovirus Receptor, Protein Binding, DNA, Complementary, Immunoblotting, Molecular Sequence Data, Nectins, Enzyme-Linked Immunosorbent Assay, Myosins, Biology, Transfection, Models, Biological, Cell Line, Adherens junction, Dogs, Nectin, Animals, Humans, Amino Acid Sequence, Molecular Biology, Sequence Homology, Amino Acid, Cadherin, Membrane Proteins, Epithelial Cells, Cell Biology, Blotting, Northern, Precipitin Tests, Molecular biology, Actins, Protein Structure, Tertiary, biology.protein, Immunoglobulin superfamily, Calcium, Peptides, Cell Adhesion Molecules
Abstract

Nectins are adhesion molecules that participate in the organization of epithelial and endothelial junctions and serve as receptors for herpes simplex virus entry. They belong to the immunoglobulin superfamily, are homologues of the poliovirus receptor (PVR/CD155), and were also named poliovirus receptor-related (PRR) proteins. We identify a new member of the nectin family named nectin4. Peptide sequences of human and murine nectin4 share 92% identity, and as for other members, the ectodomain is made of three immunoglobulin-like domains of V, C, C types. In contrast to other nectin molecules, detection of nectin4 transcripts is mainly restricted to placenta in human tissues. Expression is broader in mouse, and interestingly nectin4 is detected at days 11, 15, and 17 during murine embryogenesis. Nectin4 interacts with afadin, a F-actin-associated molecule, via its carboxyl-terminal cytoplasmic sequence. Both molecules co-localize at cadherin-based adherens junctions in the MDCKII epithelial cell line. Nectins are homophilic adhesion molecules, and recently heterophilic interactions have been described between nectin3/nectin1 and nectin3/nectin2. We confirmed these trans-interactions and also described nectin3 as the PVR/CD155 ligand. By means of several approaches, we report on the identification of nectin4 as a new ligand for nectin1. First, a soluble chimeric recombinant nectin4 ectodomain (nectin4-Fc) trans-interacts with cells expressing nectin1 but not with cells expressing nectin2, nectin3, or PVR/CD155. Conversely, nectin1-Fc binds to cells expressing nectin4. Second, nectin1-Fc precipitates nectin4 expressed in COS cells. Third, reciprocal in vitro physical interactions were detected between nectin4-Fc and nectin1-Fc. The nectin4-Fc/nectin4-Fc interaction was detected suggesting that nectin4 exhibits both homophilic and heterophilic properties. Using the same approaches we demonstrate, for the first time, that the V domain of nectin1 acts as a major functional region involved in trans-heterointeraction with nectin4 and also nectin3.

Published
2001
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20. Crossing the endothelial barrier during metastasis

Author

Barbara Borda d’Agua, Nicolas Reymond, and Anne J. Ridley

Subjects
Endothelium, General Mathematics, Biology, Basement Membrane, Metastasis, Neoplasms, medicine, Cell Adhesion, Animals, Humans, Neoplasm Invasiveness, Platelet activation, Cell Shape, Applied Mathematics, Intravasation, Transendothelial and Transepithelial Migration, Cell migration, medicine.disease, Neoplastic Cells, Circulating, Extravasation, Cell biology, Endothelial stem cell, medicine.anatomical_structure, Cancer cell, Cancer research, Endothelium, Vascular, Chemokines, Cell Adhesion Molecules
Abstract

During metastasis, cancer cells disseminate to other parts of the body by entering the bloodstream in a process that is called intravasation. They then extravasate at metastatic sites by attaching to endothelial cells that line blood vessels and crossing the vessel walls of tissues or organs. This Review describes how cancer cells cross the endothelial barrier during extravasation and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process. Identification of the mechanisms that underlie cancer cell extravasation could lead to the development of new therapies to reduce metastasis.

Published
2013

21. Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration

Author

Nicolas Reymond, Luc Xerri, Patrice Dubreuil, Elisabeth Devilard, and Marc Lopez

Subjects
Lymphocyte, High endothelial venules, Nectins, lcsh:Medicine, Biology, Cell junction, Nectin, medicine, Human Umbilical Vein Endothelial Cells, Humans, Lymphocytes, Lymphocyte homing receptor, lcsh:Science, Monocyte extravasation, Cells, Cultured, Multidisciplinary, Cell adhesion molecule, lcsh:R, Transendothelial and Transepithelial Migration, Extravasation, Cell biology, Interleukin-2 Receptor beta Subunit, medicine.anatomical_structure, Intercellular Junctions, lcsh:Q, Cell Adhesion Molecules, Research Article
Abstract

Lymphocyte trafficking and migration through vascular endothelial cells (ECs) in secondary lymphoid tissues is critical for immune protection. In the present study, we investigate the role of nectin cell adhesion molecules for the migration of lymphocytes through ECs. Nectins are key players for the establishment of homotypic and heterotypic cell to cell contacts; they are required for cell to cell adherens junction formation and take part in the transendothelial migration of monocytes during the step of diapedesis, when monocytes migrate through EC junctions. We first show that Nectin-3 (CD113) is the only nectin expressed by T lymphocytes and since nectins are expressed on ECs we explored Nectin-3 potential functions in lymphocyte: EC interactions. We demonstrate that Nectin-2, expressed on ECs, is the major counter-receptor of Nectin-3. A soluble form of Nectin-3 binds to Nectin-2 localized at EC junctions and blocking Nectin-2 trans-interactions with monoclonal antibodies abolishes the binding of soluble Nectin-3 to ECs. Nectin-2 is expressed on High Endothelial venules (HEVs), where lymphocyte homing occurs in vivo. Finally, we show that Nectin-3 trans-interaction with Nectin-2 is essential for the process of lymphocyte transendothelial migration in vitro as targeting with blocking monoclonal antibodies either Nectin-3, expressed on lymphocytes, or Nectin-2, expressed on ECs, inhibits lymphocyte extravasation. The nectin family of CAMs is important for the regulation of endothelial barrier functions and transendothelial migration of immune cells. Our results demonstrate for the first time that Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation.

Published
2013

22. Cdc42 promotes transendothelial migration of cancer cells through β1 integrin

Author

Barbara Borda d’Agua, Ritu Garg, Ferran Valderrama, Jae Hong Im, Francisco M. Vega, Ruth J. Muschel, Anne J. Ridley, Nicolas Reymond, Susan Cox, and Philippe Riou

Subjects
rac1 GTP-Binding Protein, Serum Response Factor, Lung Neoplasms, Transcription, Genetic, Integrin, Mice, SCID, CDC42, macromolecular substances, Article, Metastasis, Mice, Cell Line, Tumor, Serum response factor, Cell Adhesion, medicine, Animals, Humans, Neoplasm Metastasis, cdc42 GTP-Binding Protein, Cell adhesion, Cells, Cultured, Research Articles, biology, Integrin beta1, Transendothelial and Transepithelial Migration, Endothelial Cells, Cell Biology, medicine.disease, Fibronectins, Cell biology, Gene Expression Regulation, Neoplastic, Protein Transport, Integrin alpha M, Cancer cell, biology.protein, Cancer research, Integrin, beta 6, rhoA GTP-Binding Protein, Neoplasm Transplantation
Abstract

Cdc42 induces β1 integrin expression at the transcriptional level via the transcription factor SRF to promote cancer cell interaction with endothelial cells., Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell–endothelial cell interactions and transendothelial migration. We find that Cdc42 regulates β1 integrin expression at the transcriptional level via the transcription factor serum response factor (SRF). β1 integrin is the main target for Cdc42-mediating interaction of cancer cells with endothelial cells and the underlying extracellular matrix, as exogenous β1 integrin expression was sufficient to rescue the Cdc42-silencing phenotype. We show that Cdc42 was required in vivo for cancer cell spreading and protrusion extension along blood vessels and retention in the lungs. Interestingly, transient Cdc42 depletion was sufficient to decrease experimental lung metastases, which suggests that its role in endothelial attachment is important for metastasis. By identifying β1 integrin as a transcriptional target of Cdc42, our results provide new insight into Cdc42 function.

Published
2012

23. 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins

Author

Neil Q. McDonald, Svend Kjaer, Nicolas Reymond, Ganka Bineva, Ritu Garg, Robert J. Cain, Peter J. Parker, Philippe Riou, Nicola O’Reilly, Roger George, Brad McColl, Andrew Purkiss, Andrew J. Thompson, and Anne J. Ridley

Subjects
Models, Molecular, rho GTP-Binding Proteins, GTPase-activating protein, G protein, Molecular Sequence Data, GTPase, Biology, bcs, Crystallography, X-Ray, Article, General Biochemistry, Genetics and Molecular Biology, Cercopithecus aethiops, 03 medical and health sciences, GTP-binding protein regulators, 0302 clinical medicine, Cytosol, Chlorocebus aethiops, Animals, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Phosphorylation, Protein kinase C, 030304 developmental biology, Prenylation, 0303 health sciences, Biochemistry, Genetics and Molecular Biology(all), Rnd3, Cell Membrane, Correction, 3. Good health, Biochemistry, Membrane protein, 14-3-3 Proteins, 030220 oncology & carcinogenesis, COS Cells, Rab, 030217 neurology & neurosurgery
Abstract

Summary Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol. Rnd proteins are atypical constitutively GTP-bound Rho proteins, whose regulation remains elusive. Here, we report a high-affinity 14-3-3-binding site at the C terminus of Rnd3 consisting of both the Cys241-farnesyl moiety and a Rho-associated coiled coil containing protein kinase (ROCK)-dependent Ser240 phosphorylation site. 14-3-3 binding to Rnd3 also involves phosphorylation of Ser218 by ROCK and/or Ser210 by protein kinase C (PKC). The crystal structure of a phosphorylated, farnesylated Rnd3 peptide with 14-3-3 reveals a hydrophobic groove in 14-3-3 proteins accommodating the farnesyl moiety. Functionally, 14-3-3 inhibits Rnd3-induced cell rounding by translocating it from the plasma membrane to the cytosol. Rnd1, Rnd2, and geranylgeranylated Rap1A interact similarly with 14-3-3. In contrast to the canonical GTP/GDP switch that regulates most Ras superfamily members, our results reveal an unprecedented mechanism for G protein inhibition by 14-3-3 proteins., Graphical Abstract, Highlights • Rnd small G proteins bind to 14-3-3 via C-terminal phosphorylation and lipid groups • This interaction negatively regulates Rnd proteins by inducing membrane extraction • Structural analysis shows 14-3-3 binding to a hybrid lipid-phosphorylation motif • This motif identifies new 14-3-3-binding proteins, including Rap1A, 14-3-3 inhibit Rnd proteins by extracting them from their site of action on membranes, which is regulated by Rnd phosphorylation.

Published
2012
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24. ROCK Kinases

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, Kelvin Lau, Samuel, Michael S, and Olson, Michael F

Subjects
Rho family, proteins, ROCK kinase
Published
2012
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25. ROCK1

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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26. Rin (Ras-Like Protein in Neurons)

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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27. RIN = Ras and Rab INteractor

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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28. RAB23, Member RAS Oncogene Family

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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29. Ribosomal Protein S6 Kinase, 90kD, Polypeptide 5

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

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2012
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30. Ras Oncogenes

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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31. RXFP3: GPCR135, SALPR

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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32. R10 (Quail)

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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33. Raf-1

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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34. Rap GEF Family

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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35. RXFP4: GPCR142

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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36. ROCK I

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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37. RGS Protein Family

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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38. Resistance to Inhibitors of Cholinesterase 8

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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39. Rho-Associated Protein Kinase

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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40. Ric-8A

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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41. Retinoic Acid Receptors (RARA, RARB, and RARC)

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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42. Regulator of G-Protein Signaling 13

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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43. Ras Guanyl-Releasing Protein

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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44. Rapamycin and FKBP12 Target-1 Protein (RAFT1)

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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45. Ras-Related Protein Rab-7a

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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46. RAS D1/DEXRAS1 (AGS1)

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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47. Reggie-1 (Reg-1)

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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48. RA70 (Retinoic Acid-Induced Protein 70)

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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49. R-Type

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
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50. Relaxin Family Peptide Receptors (RXFP) 3 and 4

Author

Kirill A. Martemyanov, Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow, Carol Wicking, Soumik BasuRay, Jacob O. Agola, Patricia A. Jim, Matthew N. Seaman, Angela Wandinger-Ness, Heather H. Ward, Diamantis Konstantinidis, Theodosia A. Kalfa, Andrea Varga, Manuela Baccarini, Debbie L. Hay, Patrick M. Sexton, David R. Poyner, Carlo Petosa, Tomoki Nakashima, Hiroshi Takayanagi, Hoa B. Nguyen, Lawrence A. Quilliam, Michael S. Samuel, Philip E. Lapinski, Philip D. King, Eugenio Santos, Alberto Fernández-Medarde, John J. Priatel, Kevin Tsai, Kenneth W. Harder, Jose-Luis González de Aguilar, Pavel P. Philippov, Evgeni Yu Zernii, Masakazu Fujiwara, Mohammad Ghazizadeh, Roger J. Summers, Michelle L. Halls, Emma T. Westhuizen, Scott A. Busby, Thomas P. Burris, David P. Siderovski, Adam J. Kimple, Zhihui Xie, Kirk M. Druey, Nicolas Reymond, Francisco M. Vega, Anne J. Ridley, Gregory G. Tall, Weikang Cai, Jennifer L. Rudolph, Douglas A. Andres, John Colicelli, Pamela Y. Ting, Christine Janson, Michael F. Olson, James P. Brody, Julie A. Maupin-Furlow, Hugo V. Miranda, Philippe P. Roux, Filip Van Petegem, and Kelvin Lau

Published
2012
Full Text
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