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17 results on '"Nicolas Yannuzzi"'

1. Ergonomics of Ophthalmic Surgery: Evaluating the Effect of a Posture Trainer on Trainee Intraoperative Back Posture

Author

Zahra Markatia, Hasenin Al-Khersan, Meghana Kalavar, Arjun Watane, Nicolas Yannuzzi, and Jayanth Sridhar

Subjects
posture, posture training, intraoperative, ergonomics, ophthalmic surgery, back posture, Ophthalmology, RE1-994
Abstract

Purpose Ophthalmic surgeons are at an increased risk for musculoskeletal disorders resulting from ophthalmology-specific routines and equipment, which have become widely associated with poor posture. The purpose of this study was to observe the effect that a commercially available posture trainer, Upright Go, can have on the improvement of posture of ophthalmic surgeons.

Published
2023
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2. A kinase-independent function of AKT promotes cancer cell survival

Author

Igor Vivanco, Zhi C Chen, Barbara Tanos, Barbara Oldrini, Wan-Ying Hsieh, Nicolas Yannuzzi, Carl Campos, and Ingo K Mellinghoff

Subjects
AKT, cell survival, kinase-independent, PI3K, oncogenic, kinase inhibitor, Medicine, Science, Biology (General), QH301-705.5
Abstract

The serine–threonine kinase AKT regulates proliferation and survival by phosphorylating a network of protein substrates. In this study, we describe a kinase-independent function of AKT. In cancer cells harboring gain-of-function alterations in MET, HER2, or Phosphatidyl-Inositol-3-Kinase (PI3K), catalytically inactive AKT (K179M) protected from drug induced cell death in a PH-domain dependent manner. An AKT kinase domain mutant found in human melanoma (G161V) lacked enzymatic activity in vitro and in AKT1/AKT2 double knockout cells, but promoted growth factor independent survival of primary human melanocytes. ATP-competitive AKT inhibitors failed to block the kinase-independent function of AKT, a liability that limits their effectiveness compared to allosteric AKT inhibitors. Our results broaden the current view of AKT function and have important implications for the development of AKT inhibitors for cancer.

Published
2014
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3. Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity

Author

Nimesh A. Patel, Luis A. Acaba-Berrocal, Sandra Hoyek, Kenneth C. Fan, Maria Ana Martinez-Castellanos, Caroline R. Baumal, C. Armitage Harper, Audina M. Berrocal, Wu Wei-Chi, Rand Spencer, Shunji Kusaka, Polly Quiram, Jose Asilis, Michael P. Blair, Swati Agarwal, Anna Ells, Cagri G. Besirli, Irena Tsui, Thomas C. Lee, Aaron Nagiel, Andres Kychenthal, Jessica Kovarik, Anton Orlin, Janet Alexander, Vaidehi S. Dedania, Sengul Ozdek, Michel J. Shami, Cornelius Regan, Shilpa Desai, Moran Roni Levin, Deborah Y. Chong, Mrinali Gupta, Adam Pflugrath, Ashkan Abbey, Christopher G. Fuller, Lori E. Coors, Nicolas Yannuzzi, Catherine Negron, Hasenin Al-khersan, Paul Runge, Huseyin Baran Ozdemir, Tugce Kucukbalci, Chiharu Iwahashi, Mark Solinski, David Sutter, Jonathan Sears, Christine Sonnie, David Portney, Jake Duker, Tamara Lenis, Andreas Di-Luciano, Pablo Chamartin, Nikisha Kothari, Grecia Yael Ortiz-Ramirez, Gabriela Patricia Amadeo Oreggioni, Ameay V. Naravane, Peter J. Belin, Nahomy Ledesma Vicioso, Demetrios Vavvas, M. Elizabeth Hartnett, Robinson V.P. Chan, Eric Nudleman, Darius M. Moshfeghi, Atchara Amphornphruet, Michael Chiang, Michael J. Shapiro, J. Peter Campbell, Lejla Vajzovic, Mario Capecchi, G. Baker Hubbard, Jason Horowtiz, Rabia Karani, Rosina Negrin Martin, and Emmanuel Chang

Subjects
Ophthalmology
Published
2023
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4. Dose-Dependent and Reversible Serous Retinal Detachments in Fibroblast Growth Factor Receptor Inhibitor-Associated Retinopathy

Author

Deep Parikh, Veshesh Patel, Nicolas Yannuzzi, Scott H. Greenstein, Dean Eliott, and Leo A. Kim

Abstract

We report two cases of fibroblast growth factor receptor (FGFR) inhibitor-associated retinopathy, including the first case of Debio 1347 associated retinopathy manifesting with bilateral serous retinal detachments along the superotemporal arcades and a case of erdafitinib associated retinopathy manifesting with classic foveal serous retinal detachments. Both cases demonstrate a clear dose-dependent and reversible class effect likely secondary to downstream effects of FGFR inhibition on the MEK pathway, resulting in retinal pigment epithelial cell dysfunction, and may also involve additional mechanisms of cellular injury through inhibition of the PI3K/AKT/mTOR pathway. FGFR inhibitor-associated retinopathy appears to manifest differently among patients. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:xx–xx.]

Published
2023
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5. Practice Patterns and Outcomes of Intravitreal Anti-VEGF Injection for Retinopathy of Prematurity

Author

Nimesh A. Patel, Luis A. Acaba-Berrocal, Sandra Hoyek, Kenneth C. Fan, Maria Ana Martinez-Castellanos, Caroline R. Baumal, C. Armitage Harper, Audina M. Berrocal, Wu Wei-Chi, Rand Spencer, Shunji Kusaka, Polly Quiram, Jose Asilis, Michael P. Blair, Swati Agarwal, Anna Ells, Cagri G. Besirli, Irena Tsui, Thomas C. Lee, Aaron Nagiel, Andrés Kychenthal, Jessica Kovarik, Anton Orlin, Janet Alexander, Vaidehi S. Dedania, Sengul Ozdek, Michel J. Shami, Cornelius Regan, Shilpa Desai, Moran Roni Levin, Deborah Y. Chong, Mrinali Gupta, Adam Pflugrath, Ashkan Abbey, Christopher G. Fuller, Lori E. Coors, Nicolas Yannuzzi, Catherine Negron, Hasenin Al-khersan, Paul Runge, Huseyin Baran Ozdemir, Tugce Kucukbalci, Chiharu Iwahashi, Mark Solinski, David Sutter, Jonathan Sears, Christine Sonnie, David Portney, Jake Duker, Tamara Lenis, Andreas Di-Luciano, Pablo Chamartin, Nikisha Kothari, Grecia Yael Ortiz-Ramirez, Gabriela Patricia Amadeo Oreggioni, Ameay V. Naravane, Peter J. Belin, Nahomy Ledesma Vicioso, Demetrios Vavvas, M. Elizabeth Hartnett, Robinson V.P. Chan, Eric Nudleman, Darius M. Moshfeghi, Atchara Amphornphruet, Michael Chiang, and Michael J. Shapiro

Subjects
Ophthalmology
Published
2022
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6. Interview with Dr. Mellinghoff from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, and Igor Vivanco

Abstract

mp3 file (11 MB). In the May edition of the Cancer Discovery podcast, Science Writer Elizabeth McKenna talks with Ingo K. Mellinghoff about his paper, which suggests that the disappointing clinical activity of first-generation EGFR inhibitors in glioblastoma versus lung cancer may be attributed to the different conformational requirements of mutant EGFR in these two cancer types.

Published
2023
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7. Supplementary Figures 1-10 from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, and Igor Vivanco

Abstract

PDF file - 689K

Published
2023
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8. Supplementary Tables 1-8 from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, and Igor Vivanco

Abstract

PDF file - 104K

Published
2023
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9. Supplementary Figure and Table Legends, Methods from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, and Igor Vivanco

Abstract

PDF file - 133K

Published
2023
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10. Supplementary Figure 2 from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Author

Ingo K. Mellinghoff, Thomas G. Graeber, Jason T. Huse, Elisa Port, Cameron Brennan, Michael E. Phelps, Chris Sander, Hong Wu, Adriana Heguy, Chris Tran, Seema B. Plaisier, Richard Taschereau, Edward R. Kastenhuber, Irina Linkov, Joseph R. Osborne, Nicolas Yannuzzi, Carl Campos, Dan Rohle, Justin Wong, Evangelia Komisopoulou, Nikolaus Schultz, Steven M. Larson, and Nicolaos Palaskas

Abstract

PDF file - 256K

Published
2023
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11. Supplementary Figure 1 from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Author

Ingo K. Mellinghoff, Thomas G. Graeber, Jason T. Huse, Elisa Port, Cameron Brennan, Michael E. Phelps, Chris Sander, Hong Wu, Adriana Heguy, Chris Tran, Seema B. Plaisier, Richard Taschereau, Edward R. Kastenhuber, Irina Linkov, Joseph R. Osborne, Nicolas Yannuzzi, Carl Campos, Dan Rohle, Justin Wong, Evangelia Komisopoulou, Nikolaus Schultz, Steven M. Larson, and Nicolaos Palaskas

Abstract

PDF file - 206K

Published
2023
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12. Supplementary Figure 3 from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Author

Ingo K. Mellinghoff, Thomas G. Graeber, Jason T. Huse, Elisa Port, Cameron Brennan, Michael E. Phelps, Chris Sander, Hong Wu, Adriana Heguy, Chris Tran, Seema B. Plaisier, Richard Taschereau, Edward R. Kastenhuber, Irina Linkov, Joseph R. Osborne, Nicolas Yannuzzi, Carl Campos, Dan Rohle, Justin Wong, Evangelia Komisopoulou, Nikolaus Schultz, Steven M. Larson, and Nicolaos Palaskas

Abstract

PDF file - 260K

Published
2023
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13. Supplementary Figure Legends 1-4, Methods from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Author

Ingo K. Mellinghoff, Thomas G. Graeber, Jason T. Huse, Elisa Port, Cameron Brennan, Michael E. Phelps, Chris Sander, Hong Wu, Adriana Heguy, Chris Tran, Seema B. Plaisier, Richard Taschereau, Edward R. Kastenhuber, Irina Linkov, Joseph R. Osborne, Nicolas Yannuzzi, Carl Campos, Dan Rohle, Justin Wong, Evangelia Komisopoulou, Nikolaus Schultz, Steven M. Larson, and Nicolaos Palaskas

Abstract

Supplementary Figure Legends 1-4, Methods from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Published
2023
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14. Supplementary Figures 1-4 from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Author

Ingo K. Mellinghoff, Thomas G. Graeber, Jason T. Huse, Elisa Port, Cameron Brennan, Michael E. Phelps, Chris Sander, Hong Wu, Adriana Heguy, Chris Tran, Seema B. Plaisier, Richard Taschereau, Edward R. Kastenhuber, Irina Linkov, Joseph R. Osborne, Nicolas Yannuzzi, Carl Campos, Dan Rohle, Justin Wong, Evangelia Komisopoulou, Nikolaus Schultz, Steven M. Larson, and Nicolaos Palaskas

Abstract

Supplementary Figures 1-4 from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Published
2023
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15. Supplementary Figure 4 from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Author

Ingo K. Mellinghoff, Thomas G. Graeber, Jason T. Huse, Elisa Port, Cameron Brennan, Michael E. Phelps, Chris Sander, Hong Wu, Adriana Heguy, Chris Tran, Seema B. Plaisier, Richard Taschereau, Edward R. Kastenhuber, Irina Linkov, Joseph R. Osborne, Nicolas Yannuzzi, Carl Campos, Dan Rohle, Justin Wong, Evangelia Komisopoulou, Nikolaus Schultz, Steven M. Larson, and Nicolaos Palaskas

Abstract

PDF file - 205K

Published
2023
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16. Supplementary Tables 1-5 from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Author

Ingo K. Mellinghoff, Thomas G. Graeber, Jason T. Huse, Elisa Port, Cameron Brennan, Michael E. Phelps, Chris Sander, Hong Wu, Adriana Heguy, Chris Tran, Seema B. Plaisier, Richard Taschereau, Edward R. Kastenhuber, Irina Linkov, Joseph R. Osborne, Nicolas Yannuzzi, Carl Campos, Dan Rohle, Justin Wong, Evangelia Komisopoulou, Nikolaus Schultz, Steven M. Larson, and Nicolaos Palaskas

Abstract

XLS file - 1.38 MB

Published
2023
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