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15 results on '"Nie, Hezhongrong"'

7. Sivelestat Alleviates Atherosclerosis by Improving Intestinal Barrier Function and Reducing Endotoxemia

Author

Nie, Hezhongrong, Xiong, Qingquan, Lan, Guanghui, Song, Chunli, Yu, Xiaohong, Chen, Lei, Wang, Daming, Ren, Tingyu, Chen, Zeyan, Liu, Xintong, and Zhou, Yiwen

Subjects
Pharmacology, Pharmacology (medical)
Abstract

Emerging evidence suggests that atherosclerosis, one of the leading phenotypes of cardiovascular diseases, is a chronic inflammatory disease. During the atherosclerotic process, immune cells play critical roles in vascular inflammation and plaque formation. Meanwhile, gastrointestinal disorder is considered a risk factor in mediating the atherosclerotic process. The present study aimed to utilize sivelestat, a selective inhibitor of neutrophil elastase, to investigate its pharmacological benefits on atherosclerosis and disclose the gastrointestinal–vascular interaction. The activation of intestinal neutrophil was increased during atherosclerotic development in Western diet-fed ApoE-/- mice. Administration of sivelestat attenuated atherosclerotic phenotypes, including decreasing toxic lipid accumulation, vascular monocyte infiltration, and inflammatory cytokines. Sivelestat decreased intestinal permeability and endotoxemia in atherosclerotic mice. Mechanistically, sivelestat upregulated the expression of zonula occludens-1 in the atherosclerotic mice and recombinant neutrophil elastase protein-treated intestinal epithelial cells. Meanwhile, treatment of sivelestat suppressed the intestinal expression of inflammatory cytokines and NF-κB activity. In contrast, administration of lipopolysaccharides abolished the anti-atherosclerotic benefits of sivelestat in the Western diet-fed ApoE-/- mice. Further clinical correlation study showed that the circulating endotoxin level and intestinal neutrophil elastase activity were positively correlated with carotid intima-medial thickness in recruited subjects. In conclusion, sivelestat had pharmacological applications in protection against atherosclerosis, and intestinal homeostasis played one of the critical roles in atherosclerotic development.

Published
2021

8. Identification of Blood Exosomal miRNA-1246, miRNA-150-5p, miRNA-5787 and miRNA-8069 as Sensitive Biomarkers for Hepatitis B Virus Infection

Author

Wang, Daming, primary, Huang, Tingting, additional, Ren, Tingyu, additional, Liu, Qing, additional, Zhou, Zhuoyang, additional, Ge, Liu, additional, Chen, Zeyan, additional, Liu, Jiao, additional, Nie, Hezhongrong, additional, Ma, Wen, additional, Shen, Hongwei, additional, Liu, Chunchen, additional, Zhang, Dandan, additional, Zhou, Yiwen, additional, and Zheng, Lei, additional

Published
2022
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10. The Sampling Locations are Closely Related to the Positive Rate of Novel Coronavirus Nucleic Acid Detection

Author

Wang, Daming, primary, Wang, Hongfu, additional, Li, Shaobo, additional, Ren, Tingyu, additional, Cao, Zhaopeng, additional, Nie, Hezhongrong, additional, Chen, Zeyan, additional, Ma, Wen, additional, Wu, Yunfeng, additional, Chen, Zhongbiao, additional, Huang, Tingting, additional, Song, Chunli, additional, and Zhou, Yiwen, additional

Published
2020
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12. The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer

Author

Li Hongzhi, Jiang Yulin, Xin Yijuan, Wei Xiaosong, Jin Tao, Nie Hezhongrong, Fang Hezhi, Shen Lijun, He Jing, Chen Tao, Chen Guorong, Lu Jianxin, and Bai Yidong

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Qualitative and quantitative changes in human mitochondrial DNA (mtDNA) have been implicated in various cancer types. A 4,977 bp deletion in the major arch of the mitochondrial genome is one of the most common mutations associated with a variety of human diseases and aging. Methods We conducted a comprehensive study on clinical features and mtDNA of 104 colorectal cancer patients in the Wenzhou area of China. In particular, using a quantitative real time PCR method, we analyzed the 4,977 bp deletion and mtDNA content in tumor tissues and paired non-tumor areas from these patients. Results We found that the 4,977 bp deletion was more likely to be present in patients of younger age (≤65 years, p = 0.027). In patients with the 4,977 bp deletion, the deletion level decreased as the cancer stage advanced (p = 0.031). Moreover, mtDNA copy number in tumor tissues of patients with this deletion increased, both compared with that in adjacent non-tumor tissues and with in tumors of patients without the deletion. Such mtDNA content increase correlated with the levels of the 4,977 bp deletion and with cancer stage (p < 0.001). Conclusions Our study indicates that the mtDNA 4,977 bp deletion may play a role in the early stage of colorectal cancer, and it is also implicated in alteration of mtDNA content in cancer cells.

Published
2011
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