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26 results on '"Nieddu, Giammario"'

1. The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma

Author

Lampis, Silvia, Raieli, Salvatore, Montemurro, Luca, Bartolucci, Damiano, Amadesi, Camilla, Bortolotti, Sonia, Angelucci, Silvia, Scardovi, Anna Lisa, Nieddu, Giammario, Cerisoli, Lucia, Paganelli, Francesca, Valente, Sabrina, Fischer, Matthias, Martelli, Alberto Maria, Pasquinelli, Gianandrea, Pession, Andrea, Hrelia, Patrizia, and Tonelli, Roberto

Published
2022
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3. Data from A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

Author

Montemurro, Luca, primary, Raieli, Salvatore, primary, Angelucci, Silvia, primary, Bartolucci, Damiano, primary, Amadesi, Camilla, primary, Lampis, Silvia, primary, Scardovi, Anna Lisa, primary, Venturelli, Leonardo, primary, Nieddu, Giammario, primary, Cerisoli, Lucia, primary, Fischer, Matthias, primary, Teti, Gabriella, primary, Falconi, Mirella, primary, Pession, Andrea, primary, Hrelia, Patrizia, primary, and Tonelli, Roberto, primary

Published
2023
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4. Supplementary tables from A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

Author

Montemurro, Luca, primary, Raieli, Salvatore, primary, Angelucci, Silvia, primary, Bartolucci, Damiano, primary, Amadesi, Camilla, primary, Lampis, Silvia, primary, Scardovi, Anna Lisa, primary, Venturelli, Leonardo, primary, Nieddu, Giammario, primary, Cerisoli, Lucia, primary, Fischer, Matthias, primary, Teti, Gabriella, primary, Falconi, Mirella, primary, Pession, Andrea, primary, Hrelia, Patrizia, primary, and Tonelli, Roberto, primary

Published
2023
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5. Supplementary Methods and Fig s1-s13 from A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

Author

Montemurro, Luca, primary, Raieli, Salvatore, primary, Angelucci, Silvia, primary, Bartolucci, Damiano, primary, Amadesi, Camilla, primary, Lampis, Silvia, primary, Scardovi, Anna Lisa, primary, Venturelli, Leonardo, primary, Nieddu, Giammario, primary, Cerisoli, Lucia, primary, Fischer, Matthias, primary, Teti, Gabriella, primary, Falconi, Mirella, primary, Pession, Andrea, primary, Hrelia, Patrizia, primary, and Tonelli, Roberto, primary

Published
2023
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6. Antigene MYCN Silencing by BGA002 Inhibits SCLC Progression Blocking mTOR Pathway and Overcomes Multidrug Resistance

Author

Bortolotti, Sonia, primary, Angelucci, Silvia, additional, Montemurro, Luca, additional, Bartolucci, Damiano, additional, Raieli, Salvatore, additional, Lampis, Silvia, additional, Amadesi, Camilla, additional, Scardovi, Annalisa, additional, Nieddu, Giammario, additional, Cerisoli, Lucia, additional, Paganelli, Francesca, additional, Chiarini, Francesca, additional, Teti, Gabriella, additional, Falconi, Mirella, additional, Pession, Andrea, additional, Hrelia, Patrizia, additional, and Tonelli, Roberto, additional

Published
2023
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8. Additional file 1 of The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma

Author

Lampis, Silvia, Raieli, Salvatore, Montemurro, Luca, Bartolucci, Damiano, Amadesi, Camilla, Bortolotti, Sonia, Angelucci, Silvia, Scardovi, Anna Lisa, Nieddu, Giammario, Cerisoli, Lucia, Paganelli, Francesca, Valente, Sabrina, Fischer, Matthias, Martelli, Alberto Maria, Pasquinelli, Gianandrea, Pession, Andrea, Hrelia, Patrizia, and Tonelli, Roberto

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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9. A facile approach to the synthesis of chiral 2-substituted benzofurans

Author

De Luca, Lidia, Giacomelli, Giampaolo, and Nieddu, Giammario

Subjects
Furans -- Chemical properties, Amino acids -- Chemical properties, Biological sciences, Chemistry
Abstract

An effective route is described for optically active chiral 2-substituted benzofurans direct from carboxylic acids. This method has allowed the preparation of [alpha]-alkyl-2-benzofuranmethanamines from N-protected [alpha]-amino acids without sensible racemization phenomena and it has proceeded under mild conditions with the help of microwave irradiation.

Published
2007

10. A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

Author

Montemurro, Luca, primary, Raieli, Salvatore, additional, Angelucci, Silvia, additional, Bartolucci, Damiano, additional, Amadesi, Camilla, additional, Lampis, Silvia, additional, Scardovi, Anna Lisa, additional, Venturelli, Leonardo, additional, Nieddu, Giammario, additional, Cerisoli, Lucia, additional, Fischer, Matthias, additional, Teti, Gabriella, additional, Falconi, Mirella, additional, Pession, Andrea, additional, Hrelia, Patrizia, additional, and Tonelli, Roberto, additional

Published
2019
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11. A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

Author

Montemurro, Luca, Raieli, Salvatore, Angelucci, Silvia, Bartolucci, Damiano, Amadesi, Camilla, Lampis, Silvia, Scardovi, Anna Lisa, Venturelli, Leonardo, Nieddu, Giammario, Cerisoli, Lucia, Fischer, Matthias, Teti, Gabriella, Falconi, Mirella, Pession, Andrea, Hrelia, Patrizia, Tonelli, Roberto, Montemurro, Luca, Raieli, Salvatore, Angelucci, Silvia, Bartolucci, Damiano, Amadesi, Camilla, Lampis, Silvia, Scardovi, Anna Lisa, Venturelli, Leonardo, Nieddu, Giammario, Cerisoli, Lucia, Fischer, Matthias, Teti, Gabriella, Falconi, Mirella, Pession, Andrea, Hrelia, Patrizia, and Tonelli, Roberto

Abstract

Approximately half of high-risk neuroblastoma is characterized by MYCN amplification. N-Myc promotes tumor progression by inducing cell growth and inhibiting differentiation. MYCN has also been shown to play an active role in mitochondrial metabolism, but this relationship is not well understood. Although N-Myc is a known driver of the disease, it remains a target for which no therapeutic drug exists. Here, we evaluated a novel MYCN-specific antigene PNA oligonucleotide (BGA002) in MYCN-amplified (MNA) or MYCN-expressing neuroblastoma and investigated the mechanism of its antitumor activity. MYCN mRNA and cell viability were reduced in a broad set of neuroblastoma cell lines following BGA002 treatment. Furthermore, BGA002 decreased N-Myc protein levels and apoptosis in MNA neuroblastoma. Analysis of gene expression data from patients with neuroblastoma revealed that MYCN was associated with increased reactive oxygen species (ROS), downregulated mitophagy, and poor prognosis. Inhibition of MYCN caused profound mitochondrial damage in MNA neuroblastoma cells through downregulation of the mitochondrial molecular chaperone TRAP1, which subsequently increased ROS. Correspondingly, inhibition of MYCN reactivated mitophagy. Systemic administration of BGA002 downregulated N-Myc and TRAP1, with a concomitant decrease in MNA neuroblastoma xenograft tumor weight. In conclusion, this study highlights the role of N-Myc in blocking mitophagy in neuroblastoma and in conferring protection to ROS in mitochondria through upregulation of TRAP1. BGA002 is a potently improved MYCN-specific antigene oligonucleotide that reverts N-Myc-dysregulated mitochondrial pathways, leading to loss of the protective effect of N-Myc against mitochondrial ROS. Significance: A second generation antigene peptide oligonucleotide targeting MYCN induces mitochondrial damage and inhibits growth of MYCN-amplified neuroblastoma cells.

Published
2019

12. Bromurazione selettiva di idrossibenzilalcoli

Author

De Luca, Lidia Vera Giovanna and Nieddu, Giammario

Subjects
CHIM/06 Chimica organica
Abstract

Durante una nostra ricerca per la sintesi di benzofurani sostituiti è stato necessario adottare un metodo efficiente per la sintesi del 2-idrossibenzilbromuro: questo composto è molto instabile e i metodi di sintesi riportati in letteratura si sono rivelati inefficaci. Nel tentativo di effettuare la bromurazione usando reagenti che fossero efficaci in condizioni blande, è stato sviluppato un metodo di alogenazione, già utilizzato nei nostri laboratori che utilizza il complesso formato tra DMF e TCT.

Published
2008

13. Sintesi di librerie di benzofurani e indoli mediante strategia 'catch and release'

Author

De Luca, Lidia Vera Giovanna, Giacomelli, Giampaolo, and Nieddu, Giammario

Subjects
CHIM/06 Chimica organica
Abstract

In questo contesto viene descritto l'uso di sali di fosfonio legati ad un supporto solido per la sintesi di benzofurani mono-, di- e trisostituiti e indoli tetrasostituiti attraverso "catch and release strategy".

Published
2006

24. A Chemoselective, Easy Bromination of (Hydroxymethyl)phenols.

Author

Nieddu, Giammario

Subjects
*BROMINATION, *METHANOL, *PHENOLS, *CHEMICAL reactions, *DIMETHYLFORMAMIDE, *TEMPERATURE effect
Abstract

A simple and chemoselective method for direct bromination of (hydroxymethyl)phenols via reaction with 2,4,6-trichloro[1,3,5]triazine in N, N-dimethylformamide at room temperature is described. The reaction occurs without affecting the phenolic hydroxy group. [ABSTRACT FROM AUTHOR]

Published
2008
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25. A Practical and Efficient Approach to PNA Monomers Compatible with FmocMediated SolidPhase Synthesis ProtocolsDedicated to the memory of Dr. Charles Mioskowski

Author

Porcheddu, Andrea, Giacomelli, Giampaolo, Piredda, Ivana, Carta, Mariolino, and Nieddu, Giammario

Abstract

A straightforward synthesis of orthogonally protected PNA monomers is described. Protected aminoethylglycine Aeg monomers were efficiently prepared by reductive amination of NFmocglycinaldehyde with glycine methyl ester and the subsequent acylation of the free amine with NbisBocprotected nucleobase acetic acids. The exocyclic amine group of the nucleobases, including the notoriously difficulttoprotect guanine nucleobase, was protected with a bisBoc carbamate group; this increased the solubility of the nucleobases in the most common organic solvents. The current protocol allows all Aeg monomers to be prepared on both the micro and macroscale, which avoids or minimizes the use of toxic reagents or solvents, and moreover, cheap starting materials are used. © WileyVCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008

Published
2008
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