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35 results on '"Nielsen, Flemming S."'

13. Fish Oil in Diabetic Nephropathy

Author

Rossing, Peter, Hansen, Birgitte V., Nielsen, Flemming S., Myrup, Bjarne, Holmer, Gunhild, and Parving, Hans-Henrik

Published
1996

19. Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients

Author

Tarnow, Lise, Cambien, Francois, Rossing, Peter, Nielsen, Flemming S., Hansen, Birgitte V., Lecerf, Laure, Poirier, Odette, Danilov, Sergei, and Parving, Hans-Henrik

Subjects
Type 1 diabetes -- Genetic aspects -- Risk factors, Diabetic nephropathies -- Risk factors -- Genetic aspects, Health, Genetic aspects, Risk factors
Abstract

Genotypic abnornmalities of the renin-angiotensin system have been suggested as a risk factor for the development of diabetic nephropathy and proliferative retinopathy. We studied the relationship between an insertion(I)/deletion (D) [...]

Published
1995

20. Impact of lisinopril and atenolol on kidney function in hypertensive NIDDM subjects with diabetic nephropathy

Author

Nielsen, Flemming S., Rossing, Peter, Gall, Mari-Anne, Skott, Peter, Smidt, Ulla M., and Parving, Hans-Henrik

Subjects
Lisinopril -- Physiological aspects, Kidneys -- Physiological aspects, Diabetic nephropathies -- Drug therapy, Atenolol -- Physiological aspects, Health, Drug therapy, Physiological aspects
Abstract

Diabetic nephropathy is characterized by hypertension and a relentless decline in kidney function. Angiotensin-converting enzyme inhibitors have been claimed to preserve kidney function better than an equal blood pressure (BP) [...]

Published
1994

21. Clinical studies with oral lipid based formulations of poorly soluble compounds

Author

Dimitrios Fatouros, Karpf, Ditte M., Nielsen, Flemming S., and Anette Müllertz

Subjects
human clinical studies, lipid formulations, food effect, SEDDS, Review, emulsions, pharmacokinetics, lipophilic compounds, poorly soluble compounds
Abstract

This work is an attempt to give an overview of the clinical data available on lipid based formulations. Lipid and surfactant based formulations are recognized as a feasible approach to improve bioavailability of poorly soluble compounds. However not many clinical studies have been published so far. Several drug products intended for oral administration have been marketed utilizing lipid and surfactant based formulations. Sandimmune((R)) and Sandimmune Neoral((R)) (cyclosporin A, Novartis), Norvir((R)) (ritonavir), and Fortovase((R)) (saquinavir) have been formulated in self-emulsifying drug delivery systems (SEDDS). This review summarizes published pharmacokinetic studies of orally administered lipid based formulations of poorly aqueous soluble drugs in human subjects. Special attention has been paid to the physicochemical characteristics of the formulations, when available and the impact of these properties on the in vivo performance of the formulation. Equally important is the effect of concurrent food intake on the bioavailability of poorly soluble compounds. The effect of food on the bioavailability of compounds formulated in lipid and surfactant based formulations is also reviewed.

Published
2007

22. Low birth rate: a risk factor for development of diabetic nephropathy?

Author

Rossing, Peter, Tarnow, Lise, Nielsen, Flemming S., Hansen, Birgitte V., Brenner, Barry M., and Parving, Hans-Henrik

Subjects
Birth weight, Low -- Health aspects, Diabetic nephropathies -- Risk factors, Health, Risk factors, Health aspects
Abstract

It has been demonstrated that intrauterine growth retardation, defined as birth weight below the 10th percentile, gives rise to a reduction in nephron number. Oligonephropathy has been suggested to increase [...]

Published
1995

30. Myocardial perfusion in type 2 diabetes with left ventricular hypertrophy:normalisation by acute angiotensin-converting enzyme inhibition.

Author

Hesse, Birger, Meyer, Christian, Nielsen, Flemming S., Sato, Asako, Hove, Jens D., Holm, Soeren, Bang, Lia E., Kofoed, Klaus F., Svendsen, Tage L., Parving, Hans-Henrik, and Opie, Lionel H.

Subjects
ANGIOTENSIN converting enzyme, PERFUSION, MYOCARDIUM, POSITRON emission tomography, DIABETES, HYPERTROPHY, CORONARY disease
Abstract

The purpose of this study was to assess whether acute angiotensin-converting enzyme (ACE) inhibition would improve myocardial perfusion and perfusion reserve in a subpopulation of normotensive patients with diabetes and left ventricular hypertrophy (LVH), both independent risk factors of coronary disease. Using positron emission tomography (PET), we investigated the response of region- al myocardial perfusion to acute ACE inhibition with i.v. infusion of perindoprilat (vs saline infusion as control, minimum interval 3 days) in 12 diabetic patients with LVH. Myocardial perfusion was quantified with PET using nitrogen-13 ammonia infused at rest and during dipyrida- mole hyperaemia. Twelve healthy control subjects were in- cluded in the study, five of whom were also studied with perindoprilat. Mean blood pressure in normo-albuminuric, asymptomatic patients was 123±7/65±9 mmHg. Compared with controls, maximal perfusion was reduced in patients (1.8±0.6 vs 2.5±1.0 ml min-1 g-1; P<0.05), and perfusion reserve was also lower, at borderline significance (2.7±1.0 vs 3.6±1.3; P=0.059). During perindoprilat infusion, myo- cardial perfusion reserve in patients increased to 3.9±0.9 (P<0.001) due to normalisation of maximal perfusion (2.3±0.5 ml min-1 g-1, P<0.01). In the five control subjects both resting and hyperaemic perfusion remained un- changed during perindoprilat infusion. It is concluded that acute ACE inhibition with perindoprilat improves maximal achieved myocardial perfusion in non-hypertensive patients with diabetes and LVH. [ABSTRACT FROM AUTHOR]

Published
2004
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32. Cyclosporine Nephrotoxicity in Type 1 Diabetic Patients.

Author

Parving, Hans-Henrik, Tarnow, Lise, Nielsen, Flemming S., Rossing, Peter, Mandrup-Poulsen, Thomas, Osterby, Ruth, and Nerup, Jorn

Subjects
TREATMENT of diabetes, KIDNEY function tests, CYCLOSPORINE, DRUG efficacy
Abstract

Presents a study which evaluated kidney function seven years after the end of treatment with cyclosporine A (CsA) in young patients with newly diagnosed type 1 diabetes participating in a randomized, double-blind, placebo-controlled CsA trial. Research design and methods; Results; Conclusions.

Published
1999
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33. Civil Defence in International Humanitarian Relief Work, seen in the light of the Geneva Conventions.

Author

NIELSEN, FLEMMING S.

Abstract

The article traces the development of Civil Defence organizations in the twentieth century and the scope of their activity. The extent to which their activity is covered by the Geneva Conventions is discussed, with reference to the case of the Danish National Rescue Corps working in Bosnia-Herzegovina in 1993. The entitlement to protection of a civil defence organization working in a foreign armed conflict is seen to depend on whether the conflict is an international one, or merely a civil war. [ABSTRACT FROM PUBLISHER]

Published
1996
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