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2. Virushepatitis

Author

Boesecke, C., primary, Nierhoff, D., additional, and Schulze zur Wiesch, J., additional

Published
2018
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3. Versagen der Ultraschall-Surveillance bei Risikopatienten für das hepatozelluläre Karzinom ist häufig und mit späten Tumorstadien, nicht kurativen Therapieoptionen und höherer Mortalität assoziiert. Ergebnisse einer deutschen, multizentrischen retrospektiven Kohorten-Studie

Author

Gillessen, J, additional, Reuken, P, additional, Hunyady, P-M, additional, Reichert, M, additional, Lothschütz, L, additional, Finkelmeier, F, additional, Nowka, M, additional, Allo, G, additional, Kütting, F, additional, Bürger, M, additional, Nierhoff, D, additional, Steffen, H-M, additional, and Schramm, C, additional

Published
2021
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4. HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART

Author

Horn, C., Augustin, M., Ercanoglu, M. S., Heger, E., Knops, E., Bondet, V, Duffy, D., Chon, S-H, Nierhoff, D., Oette, M., Schaefer, H., Vivaldi, C., Held, K., Anderson, J., Geldmacher, C., Suarez, I, Rybniker, J., Klein, F., Faetkenheuer, G., Muller-Trutwin, M., Lehmann, C., Horn, C., Augustin, M., Ercanoglu, M. S., Heger, E., Knops, E., Bondet, V, Duffy, D., Chon, S-H, Nierhoff, D., Oette, M., Schaefer, H., Vivaldi, C., Held, K., Anderson, J., Geldmacher, C., Suarez, I, Rybniker, J., Klein, F., Faetkenheuer, G., Muller-Trutwin, M., and Lehmann, C.

Abstract

Objectives Despite its importance as an HIV anatomic sanctuary, little is known about the characteristics of the HIV reservoir in the terminal ileum (TI). In blood, the immune checkpoint inhibitor programmed-death-1 (PD-1) has been linked to the HIV reservoir and T-cell immune dysfunction. We thus evaluated PD-1 expression and cell-associated HIV DNA in memory CD4 T-cell subsets from TI, peripheral blood (PB) and rectum (RE) of untreated and treated HIV-positive patients to identify associations between PD-1 and HIV reservoir in other sites. Methods Using mononuclear cells from PB, TI and RE of untreated HIV-positive (N = 6), treated (n = 18) HIV-positive and uninfected individuals (n = 16), we identified and sorted distinct memory CD4 T-cell subsets by flow cytometry, quantified their cell-associated HIV DNA using quantitative PCR and assessed PD-1 expression levels using geometric mean fluorescence intensity. Combined HIV-1 RNA in situ hybridization and immunohistochemistry was performed on ileal biopsy sections. Results Combined antiretroviral therapy (cART)-treated patients with undetectable HIV RNA and significantly lower levels of HIV DNA in PB showed particularly high PD-1 expression in PB and TI, and high HIV DNA levels in TI, irrespective of clinical characteristics. By contrast, in treatment-naive patients HIV DNA levels in memory CD4 T-cell subsets were high in PB and TI. Conclusion Elevated PD-1 expression on memory CD4 T-cells in PB and TI despite treatment points to continuous immune dysfunction and underlines the importance of evaluating immunotherapy in reversing HIV latency and T-cell reconstitution. As HIV DNA particularly persists in TI despite cART, investigating samples from TI is crucial in understanding HIV immunopathogenesis.

Published
2021

6. Endoscopic versus medical management of peptic ulcers with adherent clots: Overcoming hesitation through education.

Author

Allo, G, Nierhoff, D, and Kasper, P

Subjects
*RED blood cell transfusion, *SURGICAL hemostasis, *PEPTIC ulcer, *GASTROINTESTINAL hemorrhage, *GASTROENTEROLOGISTS, *TERTIARY care
Abstract

A recent systematic review and meta-analysis on the management of peptic ulcer disease with adherent clots found that endoscopic hemostatic techniques were more effective in reducing recurrent bleeding compared to medical management alone. However, the majority of studies were conducted in high-volume centers, and the expertise of the endoscopists may not be transferable to less experienced centers. A retrospective analysis of cases at a tertiary care center confirmed the benefits of endoscopic treatment, but also highlighted the importance of training and experience in achieving successful outcomes. The authors recommend including a minimum number of emergency procedures in training programs to improve competence and confidence in managing gastrointestinal bleeding. [Extracted from the article]

Published
2024
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7. HIV DNA reservoir and elevated PD‐1 expression of CD4 T‐cell subsets particularly persist in the terminal ileum of HIV‐positive patients despite cART

Author

Horn, C, primary, Augustin, M, additional, Ercanoglu, MS, additional, Heger, E, additional, Knops, E, additional, Bondet, V, additional, Duffy, D, additional, Chon, S‐H, additional, Nierhoff, D, additional, Oette, M, additional, Schäfer, H, additional, Vivaldi, C, additional, Held, K, additional, Anderson, J, additional, Geldmacher, C, additional, Suárez, I, additional, Rybniker, J, additional, Klein, F, additional, Fätkenheuer, G, additional, Müller‐Trutwin, M, additional, and Lehmann, C, additional

Published
2021
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20. Predicting ADR from PDR and individual adenoma-to-polyp-detection-rate ratio for screening and surveillance colonoscopies: A new approach to quality assessment

Author

Schramm, C., Scheller, I., Franklin, J., Demir, M., Kuetting, F., Nierhoff, D., Goeser, T., Toex, U., Steffen, H. M., Schramm, C., Scheller, I., Franklin, J., Demir, M., Kuetting, F., Nierhoff, D., Goeser, T., Toex, U., and Steffen, H. M.

Abstract

Background and aims: Adenoma detection rate (ADR) has been established as a quality indicator for screening colonoscopy. Because ADR is cumbersome to obtain in routine practice, polyp detection rate (PDR), polypectomy rate (PR) and adenoma-to-polyp-detection-rate-ratio (APDRR) have been proposed to estimate ADR. This study aimed to evaluate APDRR in order to estimate ADR (ADR(est)) in different settings. Methods: Average risk screening and surveillance colonoscopies from a community-based private practice and a tertiary academic hospital setting were retrospectively evaluated. APDRR was calculated as averaged group APDRR for all study procedures (APDRR) and for the first half of study procedures of each gastroenterologist (APDRR(ag)) or individually for each gastroenterologist on the basis of his or her first 25, 50 and 100 colonoscopies (APDRR(ind)). ADR(est) was determined from PDR by using APDRR, APDRR(ag), and APDRR(ind), respectively. Results: A total of 2717 individuals were analyzed. Using APDRR, significant correlations between ADR and ADR(est) were observed for the entire (0.944, p<0.001), proximal (0.854, p<0.001), and distal (0.977, p<0.001) colon. These correlations were lost when APDRR(ag) was used to estimate each gastroenterologist's ADR for the second half of his or her included colonoscopies. However, ADR and ADR(est) correlated significantly with a root-mean-square-error of 6.8% and 5.8% when APDRR(ind) on the basis of each gastroenterologist's first 50 and 100 colonoscopies was used for subsequent colonoscopies. Conclusions: ADR for subsequent colonoscopies of an individual endoscopist can be reliably estimated from PDR by using an individually calculated APDRR. Prospective studies are needed to verify this promising approach in different practice settings.

Published
2017

33. Chronische Hepatits C – Versorgungsrealität in einer universitären hepatologischen Spezialambulanz

Author

Demir, M, Rodmanis, C, Schulte, S, Dahm, J, Mertens, J, Nierhoff, D, Töx, U, Goeser, T, and Steffen, HM

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Unter Studienbedingungen werden mit der Standardtherapie aus pegyliertem Interferon-α und Ribavirin bei der chronischen Hepatitis C genotypabhängig dauerhafte Viruseliminationsraten von 46–85% erreicht. Ziel der vorliegenden retrospektiven Kohortenstudie war die Analyse[for full text, please go to the a.m. URL], 10. Kongress für Infektionskrankheiten und Tropenmedizin (KIT 2010)

Published
2010
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47. Retrograde Perfusion mit Carboxyfluorescein Diacetate Succinimidyl Ester (CFDA-SE): eine neue Methode zur Visualisierung von Gallengängen und Lebergefäßen und zur Isolierung vitaler Cholangiozyten in der Maus

Author

Pryymachuk, G, primary, Polykandriotis, E, additional, Schievenbusch, S, additional, Nierhoff, D, additional, Curth, HM, additional, Odenthal, M, additional, Neiss, WF, additional, Goeser, T, additional, Steffen, HM, additional, and Töx, U, additional

Published
2011
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48. 702 RETROGRADE INFUSION OF THE BILIARY DUCT TREE WITH CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER (CFDA-SE) FOR VITAL STAINING OF BILE DUCTS AND ISOLATION OF VITAL CHOLANGIOCYTES

Author

Pryymachuk, G., primary, Polykandriotis, E., additional, Schiefenbusch, S., additional, Nierhoff, D., additional, Curth, H.-M., additional, Odenthal, M., additional, Goeser, T., additional, Neiss, W.F., additional, Steffen, H.-M., additional, and Toex, U., additional

Published
2011
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