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232 results on '"Niessen, H. W."'

1. The Netherlands Heart Tissue Bank: Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository

Author

Henkens, M. T. H. M., van Ast, J. F., te Riele, A. S. J. M., Houweling, A. C., Amin, A. S., Nijveldt, R., Antoni, M. L., Li, X., Wehrens, S. M. T., von der Thüsen, J. H., Damman, K., ter Horst, E. N., Manintveld, O. C., Abma-Schouten, R. Y., Niessen, H. W. M., Silljé, H. H. W., Jukema, J. W., and Doevendans, P. A.

Published
2023
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3. Increased bone morphogenetic protein 10 in precapillary pulmonary hypertension patients

Author

Llucia-Valldeperas, A, primary, Van Wezenbeek, J, additional, Groeneveldt, J A, additional, Smal, R, additional, Sanchez-Duffhues, G, additional, Becher, C, additional, Handoko, M L, additional, Meijboom, L, additional, Marcus, J T, additional, Symersky, P, additional, Niessen, H W M, additional, Vonk-Noordegraaf, A, additional, Bogaard, H J, additional, Goumans, M J, additional, and De Man, F S, additional

Published
2024
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5. The Netherlands Heart Tissue Bank: Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository

Author

Henkens, M T H M, van Ast, J F, Te Riele, A S J M, Houweling, A C, Amin, A S, Nijveldt, R, Antoni, M L, Li, X, Wehrens, S M T, von der Thüsen, J H, Damman, K, Ter Horst, E N, Manintveld, O C, Abma-Schouten, R Y, Niessen, H W M, Silljé, H H W, Jukema, J W, Doevendans, P A, Henkens, M T H M, van Ast, J F, Te Riele, A S J M, Houweling, A C, Amin, A S, Nijveldt, R, Antoni, M L, Li, X, Wehrens, S M T, von der Thüsen, J H, Damman, K, Ter Horst, E N, Manintveld, O C, Abma-Schouten, R Y, Niessen, H W M, Silljé, H H W, Jukema, J W, and Doevendans, P A

Abstract

AIM: Cardiac diseases remain a leading cause of cardiovascular disease (CVD) related hospitalisation and mortality. That is why research to improve our understanding of pathophysiological processes underlying cardiac diseases is of great importance. There is a strong need for healthy and diseased human cardiac tissue and related clinical data to accomplish this, since currently used animal and in vitro disease models do not fully grasp the pathophysiological processes observed in humans. This design paper describes the initiative of the Netherlands Heart Tissue Bank (NHTB) that aims to boost CVD-related research by providing an open-access biobank.METHODS: The NHTB, founded in June 2020, is a non-profit biobank that collects and stores biomaterial (including but not limited to myocardial tissue and blood samples) and clinical data of individuals with and without previously known cardiac diseases. All individuals aged ≥ 18 years living in the Netherlands are eligible for inclusion as a potential future donor. The stored samples and clinical data will be available upon request for cardiovascular researchers.CONCLUSION: To improve the availability of cardiac tissue for cardiovascular research, the NHTB will include extensive (cardiac) biosamples, medical images, and clinical data of donors with and without a previously known cardiac disease. As such, the NHTB will function as a translational bridge to boost a wide range of cardiac disease-related fundamental and translational studies.

Published
2023

7. First 12-month follow-up of bioresorbable synthetic heart valves implanted in the aortic position in sheep

Author

Vis, A, primary, De Kort, B J, additional, Szymczyk, W, additional, Van Rijswijk, J W, additional, Dekker, S, additional, Driessen, R, additional, Wijkstra, N, additional, Grundeman, P F, additional, Niessen, H W M, additional, Janssen, H M, additional, Dankers, P Y W, additional, Smits, A I P M, additional, Bouten, C V C, additional, and Kluin, J, additional

Published
2022
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9. The Netherlands Heart Tissue Bank

Author

Henkens, M. T. H. M., primary, van Ast, J. F., additional, te Riele, A. S. J. M., additional, Houweling, A. C., additional, Amin, A. S., additional, Nijveldt, R., additional, Antoni, M. L., additional, Li, X., additional, Wehrens, S. M. T., additional, von der Thüsen, J. H., additional, Damman, K., additional, ter Horst, E. N., additional, Manintveld, O. C., additional, Abma-Schouten, R. Y., additional, Niessen, H. W. M., additional, Silljé, H. H. W., additional, Jukema, J. W., additional, and Doevendans, P. A., additional

Published
2022
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11. The Netherlands Heart Tissue Bank: Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository

Author

Henkens, M T H M, van Ast, J F, Te Riele, A S J M, Houweling, A C, Amin, A S, Nijveldt, R, Antoni, M L, Li, X, Wehrens, S M T, von der Thüsen, J H, Damman, K, Ter Horst, E N, Manintveld, O C, Abma-Schouten, R Y, Niessen, H W M, Silljé, H H W, Jukema, J W, Doevendans, P A, Henkens, M T H M, van Ast, J F, Te Riele, A S J M, Houweling, A C, Amin, A S, Nijveldt, R, Antoni, M L, Li, X, Wehrens, S M T, von der Thüsen, J H, Damman, K, Ter Horst, E N, Manintveld, O C, Abma-Schouten, R Y, Niessen, H W M, Silljé, H H W, Jukema, J W, and Doevendans, P A

Abstract

AIM: Cardiac diseases remain a leading cause of cardiovascular disease (CVD) related hospitalisation and mortality. That is why research to improve our understanding of pathophysiological processes underlying cardiac diseases is of great importance. There is a strong need for healthy and diseased human cardiac tissue and related clinical data to accomplish this, since currently used animal and in vitro disease models do not fully grasp the pathophysiological processes observed in humans. This design paper describes the initiative of the Netherlands Heart Tissue Bank (NHTB) that aims to boost CVD-related research by providing an open-access biobank.METHODS: The NHTB, founded in June 2020, is a non-profit biobank that collects and stores biomaterial (including but not limited to myocardial tissue and blood samples) and clinical data of individuals with and without previously known cardiac diseases. All individuals aged ≥ 18 years living in the Netherlands are eligible for inclusion as a potential future donor. The stored samples and clinical data will be available upon request for cardiovascular researchers.CONCLUSION: To improve the availability of cardiac tissue for cardiovascular research, the NHTB will include extensive (cardiac) biosamples, medical images, and clinical data of donors with and without a previously known cardiac disease. As such, the NHTB will function as a translational bridge to boost a wide range of cardiac disease-related fundamental and translational studies.

Published
2022

22. Apoptosis in myocardial ischaemia and infarction. (Review)

Author

Krijnen, P. A. J., Nijmeijer, R., Meijer, C. J. L. M., Visser, C. A., Hack, C. E., and Niessen, H. W. M.

Subjects
Statistics, Evaluation, Physiological aspects, Myocardial ischemia -- Statistics -- Physiological aspects, Heart attack -- Statistics -- Physiological aspects, Myocardium -- Evaluation -- Statistics -- Physiological aspects, Cell death -- Physiological aspects -- Statistics, Heart cells -- Physiological aspects -- Statistics, Heart muscle -- Evaluation -- Statistics -- Physiological aspects
Abstract

Recent studies indicate that, in addition to necrosis, apoptosis also plays a role in the process of tissue damage after myocardial infarction, which has pathological and therapeutic implications. This review [...]

Published
2002

37. Hemangioma of the Atherosclerotic Changed Aortic Valve

Author

van Broekhoven, A., Krijnen, P. A. J., Niessen, H. W. M., and Vonk, A. B. A.

Subjects
body regions, Article Subject, cardiovascular system, sense organs, cardiovascular diseases, eye diseases
Abstract

The incidence of heart valve hemangioma is very low and is mostly observed in the mitral and tricuspid valve. In 2006, two cases of aortic valve hemangioma were reported for the first time, including one with calcifying aortic valve stenosis. We now present a case of aortic valve hemangioma in a patient suffering from aortic valve insufficiency combined with atherosclerotic thickening.

Published
2019
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42. Hemangioma of the Atherosclerotic Changed the Aortic Valve.

Author

van Broekhoven, A., Krijnen, P. A. J., Niessen, H. W. M., and Vonk, A. B. A.

Subjects
AORTIC valve insufficiency, AORTIC valve
Abstract

The incidence of heart valve hemangioma is very low and is mostly observed in the mitral and tricuspid valve. In 2006, two cases of aortic valve hemangioma were reported for the first time, including one with calcifying aortic valve stenosis. We now present a case of aortic valve hemangioma in a patient suffering from aortic valve insufficiency combined with atherosclerotic thickening. [ABSTRACT FROM AUTHOR]

Published
2019
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45. C4b-Binding Protein Deposition is Induced in Diseased Aortic Heart Valves, Coinciding with C3d

Author

Dikhoff, M. J., Ter Weeme, M., Vonk, A. B., Kupreishvili, K., Blom, A. M., Paul Krijnen, Stooker, W., Niessen, H. W., Cardio-thoracic surgery, Pathology, and ICaR - Heartfailure and pulmonary arterial hypertension

Abstract

BACKGROUND AND AIM OF THE STUDY: It has been found recently that activated complement is more widespread in diseased aortic valves compared to the endogenous complement inhibitors C1-inhibitor and clusterin. Previously, another endogenous inhibitor of complement, C4b-binding protein (C4BP) has been described in atherosclerotic diseased coronary arteries. The study aim was to analyze C4BP levels in diseased aortic valves.METHODS: Aortic valve tissue was derived from surgical procedures and classified as 'degenerative', 'atherosclerotic' or 'atherosclerotic with bacterial infection'. Valves were stained with specific antibodies against C4BP, C3d and caspase-3. Areas of positivity were then quantified using computer- assisted morphometry.RESULTS: In atherosclerotic valves, the areas of C4BP and C3d positivity (38.8 +/- 0.4% versus 32.7 +/- 1.0%, respectively) were significantly higher compared to the degenerative and control groups. In atherosclerotic valves with bacterial infection, the area of positivity for C4BP was even further increased compared to atherosclerotic valves (65.1 +/- 1.2%; 70.1 +/- 1.9% for C3d). The areas of C4BP and C3d positivity were not significantly different in all groups. Caspase-3 was only present in CONCLUSION: It has been shown for the first time that C4BP is deposited in the diseased aortic valve, coinciding with C3d. The area of C4BP positivity was more extensive compared to the areas of other endogenous complement inhibitors (C1-inhibitor and clusterin).

Published
2015

49. Investigating histological aspects of scars in children.

Author

Westra, I., Verhaegen, P. D. H. M., Korkmaz, H. Ibrahim, Braam, K. I., Kaspers, G. J. L., Niessen, H. W. M., and Niessen, F. B.

Subjects
LYMPHOBLASTIC leukemia treatment, BLOOD vessels, CANCER chemotherapy, COLLAGEN, COMPARATIVE studies, CONFIDENCE intervals, IMMUNE system, IMMUNOHISTOCHEMISTRY, LYMPHOCYTES, MACROPHAGES, MEDICAL equipment, NEUTROPHILS, SCARS, TUMORS in children, CROSS-sectional method, DESCRIPTIVE statistics, ODDS ratio, CHILDREN
Abstract

Objective: Very little is known about histological aspects of paediatric scars and the possible role of the immune system during their formation. In this study, the histology thoracic scars caused by the placement of an implantable central venous access device in children who underwent treatment for cancer was assessed. Method: The amount and type of collagen, the collagen orientation, the type of elastic fibres, the vascularsation, and the count of neutrophils, macrophages, and lymphocytes were analysed. The severity of scarring was assessed using the Vancouver scar scale (VSS). To evaluate the role of the immune system on scar severity and histology, the scars of children suffering from acute lymphoblastic leukaemia (ALL) were compared with the scars of children suffering from other types of childhood cancer. Results: Our results showed an extremely random orientation of the collagen fibres of the paediatric scars with a mean collagen orientation index of 0.22 (standard deviation (SD) 0.10, zero indicating a perfectly random orientation and a perfectly parallel orientation). A lower collagen orientation index was seen in scars with a lower VSS score (VSS score <3: 0.19 versus VSS score >3 0.29, p=0.037). A higher total VSS score, resembling a worse scar, was assessed to the scars in the non-ALL group compared with the children with ALL (mean ALL: 0.91 (0-3) versus mean non-ALL: 2.50 (0-6), p=0.037). Conclusion: To our knowledge, this is the first study investigating a wide array of histological aspects in paediatric scars. Compared with adult scars, an extremely random collagen orientation was found (0.22 in children versus 0.41 and 0.46 adult normotrophic and hypertrophic scars, respectively). A lower collagen orientation index was found in scars with a lower VSS score. In addition, less severe scarring was measured in children suffering from ALL compared with children suffering from other types of childhood cancer. This suggests that the immune system could play a role in the development of aberrant scarring and should be a target for future research. Declaration of interest: The authors state that they do not have any potential (financial) conflicts of interest to declare. [ABSTRACT FROM AUTHOR]

Published
2017
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50. Role of plaque inflammation in acute and recurrent coronary syndromes

Author

Meuwissen, M., van der Wal, A. C., Siebes, M., Koch, K. T., Chamuleau, S. A. J., van der Loos, C. M., Teeling, P., de Winter, R. J., Niessen, H. W. M., Tijssen, J. G. P., Becker, A. E., Piek, J. J., Pathology, Amsterdam Cardiovascular Sciences, Biomedical Engineering and Physics, Cardiology, and Extramural researchers

Abstract

Inflammation plays an important role in the initiation, development, progression and complications of atherosclerotic vascular disease. Our present knowledge of the elementary role of inflammation for the onset of plaque rupture in atherosclerotic coronary lesions primarily stems from autopsy studies. However, the introduction of directional coronary atherectomy catheters has provided a unique opportunity to directly investigate the role of inflammation in coronary syndromes. In this report we describe the role of coronary plaque inflammation, as determined by immunohistochemistry, on the presentation of coronary syndromes and on the clinical outcome following percutaneous interventions.

Published
2004

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