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2. TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells

Author

Kitajima, Hiroshi, Maruyama, Reo, Niinuma, Takeshi, Yamamoto, Eiichiro, Takasawa, Akira, Takasawa, Kumi, Ishiguro, Kazuya, Tsuyada, Akihiro, Suzuki, Ryo, Sudo, Gota, Kubo, Toshiyuki, Mitsuhashi, Kei, Idogawa, Masashi, Tange, Shoichiro, Toyota, Mutsumi, Yoshido, Ayano, Kumegawa, Kohei, Kai, Masahiro, Yanagihara, Kazuyoshi, Tokino, Takashi, Osanai, Makoto, Nakase, Hiroshi, and Suzuki, Hiromu

Published
2023
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5. Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas

Author

Aoki, Hironori, primary, Takasawa, Akira, additional, Yamamoto, Eiichiro, additional, Niinuma, Takeshi, additional, Yamano, Hiro-o, additional, Harada, Taku, additional, Kubo, Toshiyuki, additional, Yorozu, Akira, additional, Kitajima, Hiroshi, additional, Ishiguro, Kazuya, additional, Kai, Masahiro, additional, Katanuma, Akio, additional, Shinohara, Toshiya, additional, Nakase, Hiroshi, additional, Sugai, Tamotsu, additional, Osanai, Makoto, additional, and Suzuki, Hiromu, additional

Published
2023
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7. ACLP Activates Cancer-Associated Fibroblasts and Inhibits CD8+ T-Cell Infiltration in Oral Squamous Cell Carcinoma

Author

Sekiguchi, Shohei, primary, Yorozu, Akira, additional, Okazaki, Fumika, additional, Niinuma, Takeshi, additional, Takasawa, Akira, additional, Yamamoto, Eiichiro, additional, Kitajima, Hiroshi, additional, Kubo, Toshiyuki, additional, Hatanaka, Yui, additional, Nishiyama, Koyo, additional, Ogi, Kazuhiro, additional, Dehari, Hironari, additional, Kondo, Atsushi, additional, Kurose, Makoto, additional, Obata, Kazufumi, additional, Kakiuchi, Akito, additional, Kai, Masahiro, additional, Hirohashi, Yoshihiko, additional, Torigoe, Toshihiko, additional, Kojima, Takashi, additional, Osanai, Makoto, additional, Takano, Kenichi, additional, Miyazaki, Akihiro, additional, and Suzuki, Hiromu, additional

Published
2023
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10. Supplementary Table 2 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer

Author

Harada, Taku, primary, Yamamoto, Eiichiro, primary, Yamano, Hiro-o, primary, Nojima, Masanori, primary, Maruyama, Reo, primary, Kumegawa, Kohei, primary, Ashida, Masami, primary, Yoshikawa, Kenjiro, primary, Kimura, Tomoaki, primary, Harada, Eiji, primary, Takagi, Ryo, primary, Tanaka, Yoshihito, primary, Aoki, Hironori, primary, Nishizono, Masayo, primary, Nakaoka, Michiko, primary, Tsuyada, Akihiro, primary, Niinuma, Takeshi, primary, Kai, Masahiro, primary, Shimoda, Kazuya, primary, Shinomura, Yasuhisa, primary, Sugai, Tamotsu, primary, Imai, Kohzoh, primary, and Suzuki, Hiromu, primary

Published
2023
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11. Supplementary Table 1 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer

Author

Harada, Taku, primary, Yamamoto, Eiichiro, primary, Yamano, Hiro-o, primary, Nojima, Masanori, primary, Maruyama, Reo, primary, Kumegawa, Kohei, primary, Ashida, Masami, primary, Yoshikawa, Kenjiro, primary, Kimura, Tomoaki, primary, Harada, Eiji, primary, Takagi, Ryo, primary, Tanaka, Yoshihito, primary, Aoki, Hironori, primary, Nishizono, Masayo, primary, Nakaoka, Michiko, primary, Tsuyada, Akihiro, primary, Niinuma, Takeshi, primary, Kai, Masahiro, primary, Shimoda, Kazuya, primary, Shinomura, Yasuhisa, primary, Sugai, Tamotsu, primary, Imai, Kohzoh, primary, and Suzuki, Hiromu, primary

Published
2023
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12. Supplementary Table 3 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer

Author

Harada, Taku, primary, Yamamoto, Eiichiro, primary, Yamano, Hiro-o, primary, Nojima, Masanori, primary, Maruyama, Reo, primary, Kumegawa, Kohei, primary, Ashida, Masami, primary, Yoshikawa, Kenjiro, primary, Kimura, Tomoaki, primary, Harada, Eiji, primary, Takagi, Ryo, primary, Tanaka, Yoshihito, primary, Aoki, Hironori, primary, Nishizono, Masayo, primary, Nakaoka, Michiko, primary, Tsuyada, Akihiro, primary, Niinuma, Takeshi, primary, Kai, Masahiro, primary, Shimoda, Kazuya, primary, Shinomura, Yasuhisa, primary, Sugai, Tamotsu, primary, Imai, Kohzoh, primary, and Suzuki, Hiromu, primary

Published
2023
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13. Data from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer

Author

Harada, Taku, primary, Yamamoto, Eiichiro, primary, Yamano, Hiro-o, primary, Nojima, Masanori, primary, Maruyama, Reo, primary, Kumegawa, Kohei, primary, Ashida, Masami, primary, Yoshikawa, Kenjiro, primary, Kimura, Tomoaki, primary, Harada, Eiji, primary, Takagi, Ryo, primary, Tanaka, Yoshihito, primary, Aoki, Hironori, primary, Nishizono, Masayo, primary, Nakaoka, Michiko, primary, Tsuyada, Akihiro, primary, Niinuma, Takeshi, primary, Kai, Masahiro, primary, Shimoda, Kazuya, primary, Shinomura, Yasuhisa, primary, Sugai, Tamotsu, primary, Imai, Kohzoh, primary, and Suzuki, Hiromu, primary

Published
2023
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14. Supplementary Figures 1 - 4 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer

Author

Harada, Taku, primary, Yamamoto, Eiichiro, primary, Yamano, Hiro-o, primary, Nojima, Masanori, primary, Maruyama, Reo, primary, Kumegawa, Kohei, primary, Ashida, Masami, primary, Yoshikawa, Kenjiro, primary, Kimura, Tomoaki, primary, Harada, Eiji, primary, Takagi, Ryo, primary, Tanaka, Yoshihito, primary, Aoki, Hironori, primary, Nishizono, Masayo, primary, Nakaoka, Michiko, primary, Tsuyada, Akihiro, primary, Niinuma, Takeshi, primary, Kai, Masahiro, primary, Shimoda, Kazuya, primary, Shinomura, Yasuhisa, primary, Sugai, Tamotsu, primary, Imai, Kohzoh, primary, and Suzuki, Hiromu, primary

Published
2023
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15. Supplementary Figure 2 from A Novel Correlation between LINE-1 Hypomethylation and the Malignancy of Gastrointestinal Stromal Tumors

Author

Igarashi, Shinichi, primary, Suzuki, Hiromu, primary, Niinuma, Takeshi, primary, Shimizu, Haruo, primary, Nojima, Masanori, primary, Iwaki, Hiroyuki, primary, Nobuoka, Takayuki, primary, Nishida, Toshirou, primary, Miyazaki, Yasuaki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Yamamoto, Hiroyuki, primary, Tokino, Takashi, primary, Hasegawa, Tadashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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16. Supplementary Figure 1 from A Novel Correlation between LINE-1 Hypomethylation and the Malignancy of Gastrointestinal Stromal Tumors

Author

Igarashi, Shinichi, primary, Suzuki, Hiromu, primary, Niinuma, Takeshi, primary, Shimizu, Haruo, primary, Nojima, Masanori, primary, Iwaki, Hiroyuki, primary, Nobuoka, Takayuki, primary, Nishida, Toshirou, primary, Miyazaki, Yasuaki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Yamamoto, Hiroyuki, primary, Tokino, Takashi, primary, Hasegawa, Tadashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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17. Supplementary Table 1 from A Novel Correlation between LINE-1 Hypomethylation and the Malignancy of Gastrointestinal Stromal Tumors

Author

Igarashi, Shinichi, primary, Suzuki, Hiromu, primary, Niinuma, Takeshi, primary, Shimizu, Haruo, primary, Nojima, Masanori, primary, Iwaki, Hiroyuki, primary, Nobuoka, Takayuki, primary, Nishida, Toshirou, primary, Miyazaki, Yasuaki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Yamamoto, Hiroyuki, primary, Tokino, Takashi, primary, Hasegawa, Tadashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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18. Supplementary Table 2 from A Novel Correlation between LINE-1 Hypomethylation and the Malignancy of Gastrointestinal Stromal Tumors

Author

Igarashi, Shinichi, primary, Suzuki, Hiromu, primary, Niinuma, Takeshi, primary, Shimizu, Haruo, primary, Nojima, Masanori, primary, Iwaki, Hiroyuki, primary, Nobuoka, Takayuki, primary, Nishida, Toshirou, primary, Miyazaki, Yasuaki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Yamamoto, Hiroyuki, primary, Tokino, Takashi, primary, Hasegawa, Tadashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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19. Supplementary Table 7 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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20. Supplementary Table 4 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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21. Supplementary Table 6 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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22. Supplementary Table 5 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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23. Supplementary Table 2 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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24. Supplementary Table 13 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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25. Data from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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26. Supplementary Table 8 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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27. Supplementary Table 3 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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28. Supplementary Table 9 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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29. Supplementary Methods from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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30. Supplementary Figures 1-15 from Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

Author

Niinuma, Takeshi, primary, Suzuki, Hiromu, primary, Nojima, Masanori, primary, Nosho, Katsuhiko, primary, Yamamoto, Hiroyuki, primary, Takamaru, Hiroyuki, primary, Yamamoto, Eiichiro, primary, Maruyama, Reo, primary, Nobuoka, Takayuki, primary, Miyazaki, Yasuaki, primary, Nishida, Toshirou, primary, Bamba, Takeo, primary, Kanda, Tatsuo, primary, Ajioka, Yoichi, primary, Taguchi, Takahiro, primary, Okahara, Satoshi, primary, Takahashi, Hiroaki, primary, Nishida, Yasunori, primary, Hosokawa, Masao, primary, Hasegawa, Tadashi, primary, Tokino, Takashi, primary, Hirata, Koichi, primary, Imai, Kohzoh, primary, Toyota, Minoru, primary, and Shinomura, Yasuhisa, primary

Published
2023
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32. TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells

Author

Kitajima, Hiroshi, primary, Maruyama, Reo, additional, Niinuma, Takeshi, additional, Yamamoto, Eiichiro, additional, Takasawa, Akira, additional, Takasawa, Kumi, additional, Ishiguro, Kazuya, additional, Tsuyada, Akihiro, additional, Suzuki, Ryo, additional, Sudo, Gota, additional, Kubo, Toshiyuki, additional, Mitsuhashi, Kei, additional, Idogawa, Masashi, additional, Tange, Shoichiro, additional, Toyota, Mutsumi, additional, Yoshido, Ayano, additional, Kumegawa, Kohei, additional, Kai, Masahiro, additional, Yanagihara, Kazuyoshi, additional, Tokino, Takashi, additional, Osanai, Makoto, additional, Nakase, Hiroshi, additional, and Suzuki, Hiromu, additional

Published
2023
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33. Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers

Author

Yoshido, Ayano, primary, Sudo, Gota, additional, Takasawa, Akira, additional, Aoki, Hironori, additional, Kitajima, Hiroshi, additional, Yamamoto, Eiichiro, additional, Niinuma, Takeshi, additional, Harada, Taku, additional, Kubo, Toshiyuki, additional, Sasaki, Hajime, additional, Ishiguro, Kazuya, additional, Yorozu, Akira, additional, Kai, Masahiro, additional, Katanuma, Akio, additional, Yamano, Hiro‐o, additional, Osanai, Makoto, additional, Nakase, Hiroshi, additional, and Suzuki, Hiromu, additional

Published
2022
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34. CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma

Author

Yorozu, Akira, primary, Sekiguchi, Shohei, additional, Takasawa, Akira, additional, Okazaki, Fumika, additional, Niinuma, Takeshi, additional, Kitajima, Hiroshi, additional, Yamamoto, Eiichiro, additional, Kai, Masahiro, additional, Toyota, Mutsumi, additional, Hatanaka, Yui, additional, Nishiyama, Koyo, additional, Ogi, Kazuhiro, additional, Dehari, Hironari, additional, Obata, Kazufumi, additional, Kurose, Makoto, additional, Kondo, Atsushi, additional, Osanai, Makoto, additional, Miyazaki, Akihiro, additional, Takano, Kenichi, additional, and Suzuki, Hiromu, additional

Published
2022
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35. Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1

Author

Nishiyama, Koyo, Maruyama, Reo, Niinuma, Takeshi, Kai, Masahiro, Kitajima, Hiroshi, Toyota, Mutsumi, Hatanaka, Yui, Igarashi, Tomohiro, Kobayashi, Jun-ichi, Ogi, Kazuhiro, Dehari, Hironari, Miyazaki, Akihiro, Yorozu, Akira, Yamamoto, Eiichiro, Idogawa, Masashi, Sasaki, Yasushi, Sugai, Tamotsu, Tokino, Takashi, Hiratsuka, Hiroyoshi, and Suzuki, Hiromu

Published
2018
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36. Genome-Wide Analysis of microRNA and mRNA Expression in Colorectal Intramucosal Neoplasia and Colorectal Cancer With a Microsatellite-Stable Phenotype Based on Adenoma-Carcinoma Sequences

Author

Sugai, Tamotsu, primary, Osakabe, Mitsumasa, additional, Niinuma, Takeshi, additional, Sugimoto, Ryo, additional, Eizuka, Makoto, additional, Tanaka, Yoshihito, additional, Yanagawa, Naoki, additional, Otsuka, Koki, additional, Sasaki, Akira, additional, Matsumoto, Takayuki, additional, and Suzuki, Hiromu, additional

Published
2022
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37. CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma.

Author

Yorozu, Akira, Sekiguchi, Shohei, Takasawa, Akira, Okazaki, Fumika, Niinuma, Takeshi, Kitajima, Hiroshi, Yamamoto, Eiichiro, Kai, Masahiro, Toyota, Mutsumi, Hatanaka, Yui, Nishiyama, Koyo, Ogi, Kazuhiro, Dehari, Hironari, Obata, Kazufumi, Kurose, Makoto, Kondo, Atsushi, Osanai, Makoto, Miyazaki, Akihiro, Takano, Kenichi, and Suzuki, Hiromu

Subjects
STROMAL cell-derived factor 1, MUSCLE cells, SQUAMOUS cell carcinoma, SKELETAL muscle, TONGUE
Abstract

Background: The CXCL12/CXCR4 axis plays a pivotal role in the progression of various malignancies, including oral squamous cell carcinoma (OSCC). In this study, we aimed to clarify the biological and clinical significance of CXCL12 in the tumor microenvironment of OSCCs. Methods: Publicly available single‐cell RNA‐sequencing (RNA‐seq) datasets were used to analyze CXCL12 expression in head and neck squamous cell carcinomas (HNSCC). Immunohistochemical analysis of CXCL12, α‐smooth muscle antigen (α‐SMA), fibroblast activation protein (FAP) and CD8 was performed in a series of 47 surgically resected primary tongue OSCCs. Human skeletal muscle cells were co‐cultured with or without OSCC cells, after which CXCL12 expression was analyzed using quantitative reverse‐transcription PCR. Results: Analysis of the RNA‐seq data suggested CXCL12 is abundantly expressed in stromal cells within HNSCC tissue. Immunohistochemical analysis showed that in grade 1 primary OSCCs, CXCL12 is expressed in both tumor cells and muscle cells. By contrast, grade 3 tumors were characterized by disruption of muscle structure and reduced CXCL12 expression. Quantitative analysis of CXCL12‐positive areas within tumors revealed that reduced CXCL12 expression correlated with poorer overall survival. Levels of CXCL12 expression tended to inversely correlate α‐SMA expression and positively correlate with infiltration by CD8+ lymphocytes, though these relations did not reach statistical significance. CXCL12 was significantly upregulated in muscle cells co‐cultured with OSCC cells. Conclusion: Our results suggest that tongue OSCC cells activate CXCL12 expression in muscle cells, which may contribute to tumor progression. However, CXCL12 is reduced in advanced OSCCs due to muscle tissue destruction. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a microsatellite instability phenotype

Author

Sugai, Tamotsu, primary, Osakabe, Mitsumasa, additional, Niinuma, Takeshi, additional, Eizuka, Makoto, additional, Tanaka, Yoshihito, additional, Yamada, Shun, additional, Yanagawa, Naoki, additional, Otsuka, Koki, additional, Sasaki, Akira, additional, Matsumoto, Takayuki, additional, and Suzuki, Hiromu, additional

Published
2021
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41. Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.

Author

Yoshido, Ayano, Sudo, Gota, Takasawa, Akira, Aoki, Hironori, Kitajima, Hiroshi, Yamamoto, Eiichiro, Niinuma, Takeshi, Harada, Taku, Kubo, Toshiyuki, Sasaki, Hajime, Ishiguro, Kazuya, Yorozu, Akira, Kai, Masahiro, Katanuma, Akio, Yamano, Hiro‐o, Osanai, Makoto, Nakase, Hiroshi, and Suzuki, Hiromu

Subjects
NEUTROPHILS, COLORECTAL cancer, CELL migration, AMYLOID, IMMUNOHISTOCHEMISTRY
Abstract

Background and Aim: The tumor microenvironment plays an essential role in the development and progression of colorectal cancer (CRC). We recently reported that crosstalk between CRC cells and tumor‐associated macrophages (TAMs) via serum amyloid A1 (SAA1) promotes invasion by T1 CRCs. In the present study, we aimed to clarify the role of neutrophils in early CRCs. Methods: Immunohistochemical analysis of CD66b, chemokine CXC motif ligand 8 (CXCL8 or interleukin‐8, IL‐8) and matrix metalloproteinase‐9 (MMP‐9) was performed using primary T1 CRCs (n = 49). The HL‐60 human promyelocytic leukemia cell line and THP‐1 human monocytic leukemia cell line were used to obtain neutrophil‐like and macrophage‐like cells, respectively. Boyden chamber assays were used to analyze cell migration and invasion, and quantitative RT‐PCR was used to analyze gene expression. Results: Immunohistochemical analysis revealed accumulation of neutrophils at the SAA1‐positive invasive front of T1 CRCs. Experiments using HL‐60 cells suggested that treatment with SAA1 induced neutrophil migration and expression of CXCL8 and MMP‐9 in neutrophils and that neutrophils promote CRC cell migration and invasion. Immunohistochemistry confirmed accumulation of CXCL8‐ or MMP‐9‐positive neutrophils at the SAA1‐positive invasive front of T1 CRCs. Moreover, co‐culture experiments using CRC, THP‐1 and HL‐60 cells suggested that CRC cells activated by macrophages upregulate CXCL8 and MMP‐9 in neutrophils. Conclusions: Our results suggest that interplay between macrophages and CRC cells leads to recruitment of neutrophils to the invasive front of T1 CRCs and that SAA1 secreted by CRC cells activate neutrophils to promote invasion. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Activated macrophages promote invasion by early colorectal cancer via an interleukin 1β‐serum amyloid A1 axis

Author

Sudo, Gota, primary, Aoki, Hironori, additional, Yamamoto, Eiichiro, additional, Takasawa, Akira, additional, Niinuma, Takeshi, additional, Yoshido, Ayano, additional, Kitajima, Hiroshi, additional, Yorozu, Akira, additional, Kubo, Toshiyuki, additional, Harada, Taku, additional, Ishiguro, Kazuya, additional, Kai, Masahiro, additional, Katanuma, Akio, additional, Yamano, Hiro‐o, additional, Osanai, Makoto, additional, Nakase, Hiroshi, additional, and Suzuki, Hiromu, additional

Published
2021
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44. An Integrated Epigenome and Transcriptome Analysis to Clarify the Effect of Epigenetic Inhibitors on GIST

Author

NIINUMA, TAKESHI, primary, KITAJIMA, HIROSHI, additional, YAMAMOTO, EIICHIRO, additional, MARUYAMA, REO, additional, AOKI, HIRONORI, additional, HARADA, TAKU, additional, ISHIGURO, KAZUYA, additional, SUDO, GOTA, additional, TOYOTA, MUTSUMI, additional, YOSHIDO, AYANO, additional, KAI, MASAHIRO, additional, NAKASE, HIROSHI, additional, SUGAI, TAMOTSU, additional, and SUZUKI, HIROMU, additional

Published
2021
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46. Upregulation of adipocyte enhancer‐binding protein 1 in endothelial cells promotes tumor angiogenesis in colorectal cancer

Author

Yorozu, Akira, primary, Yamamoto, Eiichiro, additional, Niinuma, Takeshi, additional, Tsuyada, Akihiro, additional, Maruyama, Reo, additional, Kitajima, Hiroshi, additional, Numata, Yuto, additional, Kai, Masahiro, additional, Sudo, Gota, additional, Kubo, Toshiyuki, additional, Nishidate, Toshihiko, additional, Okita, Kenji, additional, Takemasa, Ichiro, additional, Nakase, Hiroshi, additional, Sugai, Tamotsu, additional, Takano, Kenichi, additional, and Suzuki, Hiromu, additional

Published
2020
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50. Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy: A case report.

Author

Kazuya Ishiguro, Yasushi Sasaki, Yoshitake Takagi, Takeshi Niinuma, Hiromu Suzuki, Takashi Tokino, Toshiaki Hayashi, Tohru Takahashi, Tetsuyuki Igarashi, Yoshihiro Matsuno, Ishiguro, Kazuya, Sasaki, Yasushi, Takagi, Yoshitake, Niinuma, Takeshi, Suzuki, Hiromu, Tokino, Takashi, Hayashi, Toshiaki, Takahashi, Tohru, Igarashi, Tetsuyuki, and Matsuno, Yoshihiro

Published
2020
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