1. Blood levels of heme oxygenase-1 versus bilirubin in patients with coronary artery disease.
- Author
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Kishimoto, Yoshimi, Niki, Hanako, Saita, Emi, Ibe, Susumu, Umei, Tomohiko, Miura, Kotaro, Ikegami, Yukinori, Ohmori, Reiko, Kondo, Kazuo, and Momiyama, Yukihiko
- Subjects
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CORONARY disease , *BILIRUBIN , *CORONARY angiography - Abstract
• Plasma HO-1 levels were significantly higher in patients with CAD, especially in 1-VD, than in those without CAD. • In contrast, serum bilirubin levels were significantly lower in patients with CAD than in those without CAD. • There was no correlation between HO-1 and bilirubin levels. • In a multivariate analysis, HO-1, but not bilirubin, level was an independent factor for CAD. Heme oxygenase-1 (HO-1) degrades heme to CO, iron, and biliverdin/bilirubin. Although serum bilirubin levels were often reported in patients with coronary artery disease (CAD), HO-1 levels in patients with CAD and the association between HO-1 and bilirubin levels have not been clarified. We measured plasma HO-1 and serum total bilirubin levels in 262 patients undergoing coronary angiography. HO-1 levels were higher in patients with CAD than without CAD (median 0.46 vs. 0.35 ng/mL, P < 0.01), but bilirubin were lower in patients with CAD than without CAD (0.69 vs. 0.75 mg/dL, P < 0.02). Notably, HO-1 levels in CAD(−), 1-vessel, 2-vessel, and 3-vessel disease were 0.35, 0.51, 0.45, and 0.44 ng/mL, and were highest in 1-vessel disease (P < 0.05). Bilirubin levels in CAD(−), 1-vessel, 2-vessel, and 3-vessel disease were 0.75, 0.70, 0.68, and 0.66 mg/dL (P = NS). No correlation was found between HO-1 and bilirubin levels. In multivariate analysis, HO-1 levels were a significant factor for CAD independent of atherosclerotic risk factors and bilirulin levels. Odds ratio for CAD was 2.32 (95%CI = 1.29–4.17) for high HO-1 (>0.35 ng/mL). Patients with CAD were found to have high HO-1 and low bilirubin levels in blood, but no correlation was found between HO-1 and bilirubin levels. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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