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Abstract Objective To assess the relationship between abdominal pain severity during the menopausal transition (MT) and age, MT stage, reproductive biomarkers, stress biomarkers, and stress perceptions. Methods Women ages 35–55 were recruited from multiethnic neighborhoods in the greater Seattle area from 1990 to 1992, for an original study cohort of 508. From 1990 to 2013, a subset of this cohort consented to ongoing annual data collection by annual health questionnaire, health diary, and daily menstrual calendar. Beginning in 1997, a portion of these women also provided a first morning voided urine specimen to be assayed for levels of estrone glucuronide (E1G), follicle stimulating hormone (FSH), testosterone, cortisol, norepinephrine, and epinephrine. To identify how changes in abdominal pain severity changed over time in relation to age, MT stage, reproductive biomarkers, stress-related biomarkers, and stress-related perceptions, mixed effects modeling was used. Results In a univariate model, E1G (p = 0.02) and testosterone (p = 0.02) were significantly and negatively related to abdominal pain severity, while perceived stress (p = 0.06), tension (p

Central giant cell granuloma CGCG is a benign expansile osteolytic lesion of the jawbone. Previously termed a central giant cell CGC reparative granuloma it is now more accurately classified as a CGC tumor as it represents a benign neoplasm of osteoclast precursors. Surgery is the standard course of treatment for CGCG. On the other hand morbidity is linked to surgical care. Conservative treatment modalities such as interferon alpha therapy calcitonin therapy and intralesional corticosteroid injections can significantly reduce postoperative morbidity however it is important to follow up on these cases for an extended period in order to study the effects and potential recurrence of these cases. Three CGC tumour cases are presented in this case series.

Abstract SKLB1028 is a novel multi‐target protein kinase inhibitor under investigation for the treatment of FLT3‐ITD mutated acute myeloid leukemia. Based on the preclinical characterization of SKLB1028 metabolism, three drug–drug interaction clinical studies were performed to investigate the effects of itraconazole, rifampin (CYP3A4 inhibitor and inducer, respectively), and gemfibrozil (CYP2C8 inhibitor) on the metabolism of SKLB1028. Fourteen healthy Chinese male subjects were enrolled in each study. In Study 1, subjects were administered a single dose of SKLB1028 (100 mg on days 1 and 11) and multiple doses of itraconazole (200 mg twice daily on day 8 and 200 mg once daily from days 9 to 18). Itraconazole was given with a loading dose on Day 8 and the total administration of itraconazole was 11 days. In Study 2, subjects were administered a single dose of SKLB1028 (100 mg on days 1 and 12) and multiple doses of gemfibrozil (600 mg twice daily from days 8 to 19). In Study 3, subjects were administered a single dose of SKLB1028 (150 mg on days 1 and 15) and multiple doses of rifampin (600 mg once daily from day 8 to 22). Itraconazole increased the AUC and Cmax of SKLB1028 by approximately 28% and 41%, respectively. Compared to the single drug, co‐administration with gemfibrozil increased the AUC of SKLB1028 by ~26% and the Cmax by ~21%. Co‐administration with rifampin reduced the AUC of SKLB1028 by ~30%, while the Cmax did not change significantly. All treatments were well tolerated in all three studies.

Abstract The two-phase compression process in the rotary compressor often occurs, such as defrosting and startup processes, which has a significant impact on the performance and reliability of air conditioning systems. In this paper, the CFD simulations predicting the two-phase refrigerant compression process in the compressor cylinder are conducted using the commercial software ANSYS Fluent. The dynamic mesh for the fluid domain and phase change model for the refrigerant are considered in the simulation. Effects of initial liquid volume fraction, refrigerant type and compressor type on the two-phase compression characteristics using R290 as refrigerant are carried out. Variations of the pressure, temperature, gas fraction distribution and evaporation rate in the cylinder are discussed. The results show that most liquid accumulates near the leakage gap and the bottom of the compression chamber during the two-phase compression process. The peak pressure during the two-phase compression decreases with the increase of the liquid volume fraction. The evaporation rate of R32 in the cylinder is much higher than that of R290. The maximum pressure of the reciprocating compressor is 2.26 times higher than that of the rotary compressor.

In this study, a novel solar-assisted heat pump (SAHP) system with hybrid thermal energy storage is proposed. The system can address the problems of large space requirements and the unstable heating of solar heating systems and tackle the energy-efficient degradation of air source heat pumps (ASHPs) in winter. This study utilized TRNSYS18 software to establish a dynamic simulation model of the system, including the system’s model construction and the control scheme’s design. This performance study focused on analyzing the effects of the collector area and thermal energy storage (TES). The results show that with the increase in the collector area, the collector and power generation efficiencies decrease, and the system performance coefficient improves; the rise in the volume of TES leads to the collector and power generation efficiencies first increasing, and then they tend to stabilize, and the performance coefficient shows a trend of firstly increasing, and then decreasing. In terms of parameter optimization, a target optimization scheme and an evaluation model are constructed. The results indicate that the heating demand for a 116-square-meter building in the Tianjin area is met. The equivalent annual cost (EAC) of the system cost is the lowest, which is CNY 3963, when the collector area of the system is 31 square meters, the heat storage tank (HST) volume is 0.4 cubic meters and the phase-change energy storage (PCES) volume is 0.2 cubic meters. The payback period of the system is 10.59 years, which was compared to that of the ASHP. The further comparison of the economic feasibility of the system in the Lhasa, Shenyang, and Tianjin regions shows that the Lhasa region has the lowest EAC and payback period of CNY 1579 and 8.53 years, respectively, while the payback periods of Tianjin and Shenyang are 10.59 and 10.3 years, with EACs of CNY 3963 and CNY 5096, respectively.

Leukemia stem cells (LSC) are a rare population capable of limitless self-renewal and are responsible for the initiation, maintenance, and relapse of leukemia. Elucidation of the mechanisms underlying the regulation of LSC function could provide novel treatment strategies. Here, we show that TWIST1 is extremely highly expressed in the LSC of MLL-AF9+ acute myeloid leukemia (AML), and its upregulation is positively regulated by KDM4C in a H3K9me3 demethylation-dependent manner. We further demonstrate that TWIST1 is essential for the viability, dormancy, and self-renewal capacities of LSC, and that it promotes the initiation and maintenance of MLL-AF9-mediated AML. In addition, TWIST1 directly interacts and collaborates with HOXA9 in inducing AML in mice. Mechanistically, TWIST1 exerts its oncogenic function by activating the WNT5a/RAC1 axis. Collectively, our study uncovers a critical role of TWIST1 in LSC function and provides new mechanistic insights into the pathogenesis of MLL-AF9+ AML.

Currently, two-dimensional (2D) materials with intrinsic antiferromagnetism have stimulated research interest due to their insensitivity to external magnetic fields and absence of stray fields. Here, we predict a family of stable transition metal (TM) borides, TMB12 (TM = V, Cr, Mn, Fe) monolayers, by combining TM atoms and B12 icosahedra based on first-principles calculations. Our results show that the four TMB12 monolayers have stable antiferromagnetic (AFM) ground states with large magnetic anisotropic energy. Among them, three TMB12 (TM=V, Cr, Mn) monolayers display an in-plane easy magnetization axis, while the FeB12 monolayer has an out-of-plane easy magnetization axis. Among them, the CrB12 and the FeB12 monolayers are AFM semiconductors with band gaps of 0.13 eV and 0.35 eV, respectively. In particular, the AFM FeB12 monolayer is a spin-polarized AFM material with a Néel temperature of 125 K. Moreover, the electronic and magnetic properties of the CrB12 and the FeB12 monolayers can be modulated by imposing external biaxial strains. Our findings show that the TMB12 monolayers are candidates for designing 2D AFM materials, with potential applications in electronic devices.

Liquid often exists in the accumulator of the rotary compressor during the process of startup or defrost of air-conditioning systems. Too much liquid entering the compressor cylinder would result in excessive pressure caused by the liquid compression, which is a great threat to the compressor. The liquid return through the liquid-return hole is the key to ensure the stable operation of the compressor. In this paper, the liquid-return characteristics in the liquid-return holes of the accumulator, including the mass-flow rate, liquid velocity and pressure difference between the liquid-return holes, during the startup process of the R290 rotary compressor are numerically investigated. The numerical simulation using the fluent volume of fluid (VOF) method was experimentally validated with the error of 1.55%. The comparison of liquid-return characteristics using different refrigerants is conducted. Effects of refrigerant solubility in the oil, refrigerant/oil-mixture type, liquid-return-hole diameter and compressor frequency on the liquid-return characteristics and liquid shape trough the liquid-return hole are discussed. The results show that the surface tension and viscosity of the liquid are the main factors affecting the liquid-return speed. The liquid-return rate of the refrigerant R290 is slower than that of other refrigerants R22 and R410A. The liquid-return rate increases with the increase in the compressor frequency. We conclude that for air-conditioning systems using R290 as refrigerant, increasing the number of return holes or the hole diameter is necessary to improve the liquid-return characteristics of the compressor. This research will provide theoretical guidance for the optimization of liquid return of rotary compressors using new refrigerants.