Search

Past work points to the crucial role of parents' responses to children's negative emotions (PRCNE) in adolescents' socioemotional adjustment. The presence of suicidal ideation (SI) is an important sign of significant distress and suicide risk. However, research on the relations between PRCNE and adolescents' SI is lacking. This research aimed to investigate whether parental reactions to children's negative emotions (PRCNE) was related to adolescents' SI and, if so, through which processes. This research utilized data from a sample of Chinese adolescent families (N = 4,574; Parents: 35.81% males, M = 44.07 years old; Adolescents: 55.40% males, M = 16.28 years old), with parents giving their reports on PRCNE and adolescents self-evaluating their psychosocial development (i.e., internalizing problems, emotion regulation, perceived relationship quality with parents) and SI. We examined the relations between six types of PRCNE and adolescents' SI, and analyzed the mediating roles of adolescents' internalizing problems, emotion regulation (i.e., cognitive reappraisal and expressive suppression), and perceived relationship quality with parents. The results showed that emotion-focused response, problem-focused response, and expression encouragement negatively predicted, while punitive response and distress response positively predicted adolescents' SI. However, no statistically significant association emerged between minimization and adolescents' SI. Moreover, adolescents' internalizing problems, usage of expressive suppression, and perceived relationship quality with parents could mediate the relations between PRCNE and adolescents' SI. Contrary to our hypothesis, the results did not support an indirect effect of PRCNE on adolescents' SI through adolescents' cognitive reappraisal. The present research illuminates adolescents' SI by emphasizing the roles of PRCNE. The findings also highlight the importance of paying attention to adolescents' internalizing problems, expressive suppression, and perceived relationship quality with parents in relation to PRCNE in interventions aimed at reducing adolescents' SI.

Background Nonsuicidal self-injury (NSSI) is a serious public health concern among adolescents. However, adolescents with different combinations of NSSI risk factors may constitute different subgroups that vary in subsequent risks of NSSI engagement, and the membership in these subgroups may change during early adolescence. Gender differences related to risk profiles and transition patterns may also exist. This study thus aimed to address these three questions. Methods A total of 2,942 participants ranging from 12 to 17 years old (55.2% females; Mage = 14.60, SD = 1.21) completed a series of questionnaires about NSSI and its risk factors on three occasions, every six months. Latent profile and latent transition analyses were used to examine NSSI risk profiles (subgroups), their transition patterns, and gender differences. Results Three distinct risk profiles were identified: Low-risk profile, Medium-risk profile, and High-risk profile. The profile membership was fairly stable over one year, and the shift across profiles represented a “resilient” pattern. Regarding gender differences, boys were less likely to be in either the Medium- or the High-risk groups, but more likely to transition from the Medium- to the Low-risk group, relative to girls. Limitations This study relied upon self-report measures. Additional research is needed to investigate the generalizability of the results to other populations, and to examine more predictors of class membership and transitions. Conclusions The results highlight the importance of considering subgroup differences in understanding NSSI risks. Differentiated interventions with multi-pronged approaches tailoring to different risk classes and gender groups may therefore prove more efficient and effective.

Bullying experiences play an important role in non-suicidal self-injury (NSSI). However, little is known about how and in what conditions different bullying experiences (i.e., experiences of being pure bullies, pure victims, and bully-victims) may influence NSSI. Guided by the transactional model of development and the integrated model of NSSI, the current study investigated two potential mediators (i.e., peer acceptance and depressive symptoms) and one potential moderator (i.e., psychological resilience) of the relations between different bullying experiences and NSSI. Participants were 812 Chinese adolescents (43% female; Mage at Wave 1 = 13.15 years) from a two-wave longitudinal study with data spanning 1 year. The results show that all three types of bullying experiences can relate to a higher likelihood of NSSI through two indirect pathways: (a) lower peer acceptance to more depressive symptoms, or (b) more depressive symptoms. These indirect effects were weaker for adolescents with higher (versus lower) levels of psychological resilience. Moreover, when bully-victims were distinguished from pure bullies and pure victims and the unique effects for all three groups were tested, the direct and indirect effects were most evident among bully-victims. These findings imply that it is necessary to distinguish bully-victims from pure bullies and pure victims. The results indicate that NSSI may be effectively reduced if interventions focus on promoting peer acceptance and reducing adolescent depressive symptoms, particularly for bully-victims with lower levels of psychological resilience.

The meta-CAr-H bond formylation of arenes has been achieved using CHBr3 as a formyl source in the presence of [Ru(p-cym)(OAc)2] as a catalyst. This method provides efficient access to the preparation of various meta-substituted aromatic compounds, such as alcohols, ethers, amines, nitriles, alkenes, halogens, carboxylic acids, and their derivatives, through transformation of the versatile formyl group. Furthermore, mechanistic studies show that the key active species is a pentagonal ruthenacycle complex.

Drawing on the resilience-oriented socioecological framework, the current study contributes to scarce scholarship by exploring intrapersonal (i.e., gratitude) and interpersonal (i.e., parental autonomy support) factors in the longitudinal association between bullying victimization and adolescent non-suicidal self-injury (NSSI). Participants were 238 Chinese adolescents (Mage at Time 1 (T1) = 13.45 years; 106 girls and 132 boys) based on a two-wave prospective design with data spanning one year. At T1, adolescents self-rated all study variables, and at Time 2 (T2), youth again reported their NSSI. The results showed a significant main effect (b = 0.12, SE = 0.05, p = 0.04), indicating that bullying victimization was positively related to T2 NSSI one year later, even controlling for T1 NSSI. Moderation analyses further indicated that parental autonomy support buffered against the positive association between bullying victimization and T2 NSSI, but only when adolescents experienced lower levels of gratitude. Specifically, for adolescents with lower levels of gratitude, high levels of parental autonomy support, in a compensatory way, prevented adolescents from NSSI after victimization occurred (b = −0.03, SE = 0.09, p = 0.78); by contrast, for those with higher levels of gratitude, bullying victimization was not significantly related to T2 NSSI, regardless of the levels of parental autonomy support (b = 0.07, SE = 0.04, p = 0.59 for higher parental autonomy support; b = 0.01, SE = 0.07, p = 0.93 for lower parental autonomy support). These findings suggest that gratitude and parental autonomy support, manifesting in a compensatory interaction pattern, could serve as targeted agents for breaking the vicious linkage between bullying victimization and NSSI.

This study examined the unique contributions of paternal and maternal emotion dysregulation to children's emotion regulation and lability, and whether parental emotion dysregulation was transmitted to their children indirectly through their own and their spouses' reactions to children's negative emotions. Participants were 118 couples in families with at least one school-age child in Guangdong province, southern China. Fathers and mothers reported on difficulties in their emotion regulation, their reactions to children's negative emotions, and their perceptions of children's emotion regulation and lability. Results revealed that both paternal and maternal emotion dysregulation were uniquely associated with children's emotion regulation and lability. Furthermore, significant actor effects were found between paternal and maternal emotion dysregulation and their own reactions to children's negative emotions, whereas only one significant partner effect was found between maternal emotion dysregulation and paternal reactions to children's negative emotions. Additionally, the relationship between maternal emotion dysregulation and fathers' report of children's emotion regulation was mediated by maternal unsupportive reactions and paternal supportive reactions, and the relationship between paternal emotion dysregulation and fathers' report of children's emotion regulation was mediated by paternal supportive reactions. These findings illustrated the mechanism of intergenerational transmission of emotion regulation.

COVID-19 places unprecedented demands on the oncology ecosystem. The extensive pressure of managing health care during the pandemic establishes the need for rapid implementation of telemedicine. Across our large statewide practice of 640 practitioners at 221 sites of service, an aggressive multidisciplinary telemedicine strategy was implemented in March by coordinating and training many different parts of our healthcare delivery system. From March to September, telemedicine grew to serve 15%-20% of new patients and 20%-25% of established patients, permitting the practice to implement safety protocols and reduce volumes in clinic while continuing to manage the acute and chronic care needs of our patient population. We surveyed practice leaders, queried for qualitative feedback, and established 76% were satisfied with the platform. The common challenges for patients were the first-time use and technology function, and patients were, in general, grateful and happy to have the option to visit their clinicians on a telemedicine platform. In addition to conducting new and established visits remotely, telemedicine allows risk assessments, avoidance of hospitalization, family education, psychosocial care, and improved pharmacy support. The implementation has limitations including technical complexity; increased burden on patients and staff; and broadband access, particularly in rural communities. For telemedicine to improve as a solution to enhance the longitudinal care of patients with cancer, payment coverage policies need to continue after the pandemic, technologic adoption needs to be easy for patients, and broadband access in rural areas needs to be a policy priority. Further research to optimize the patient and clinician experience is required to continue to make progress.

Bullying experiences play an important role in non-suicidal self-injury (NSSI). However, little is known about how and in what conditions different bullying experiences (i.e., experiences of being pure bullies, pure victims, and bully-victims) may influence NSSI. Guided by the transactional model of development and the integrated model of NSSI, the current study investigated two potential mediators (i.e., peer acceptance and depressive symptoms) and one potential moderator (i.e., psychological resilience) of the relations between different bullying experiences and NSSI. Participants were 812 Chinese adolescents (43% female; Mage at Wave 1 = 13.15 years) from a two-wave longitudinal study with data spanning 1 year. The results show that all three types of bullying experiences can relate to a higher likelihood of NSSI through two indirect pathways: (a) lower peer acceptance to more depressive symptoms, or (b) more depressive symptoms. These indirect effects were weaker for adolescents with higher (versus lower) levels of psychological resilience. Moreover, when bully-victims were distinguished from pure bullies and pure victims and the unique effects for all three groups were tested, the direct and indirect effects were most evident among bully-victims. These findings imply that it is necessary to distinguish bully-victims from pure bullies and pure victims. The results indicate that NSSI may be effectively reduced if interventions focus on promoting peer acceptance and reducing adolescent depressive symptoms, particularly for bully-victims with lower levels of psychological resilience.

The

Molecular dynamics simulations (MDS) are employed to investigate the effects of interatomic interaction and nanostructure on wettability of water on a copper plate. In the nano scale, these simulat...

Parents’ educational aspirations for youth play an important role in shaping youth’s own educational aspirations; however, little is known about how and in what context parents may transmit their aspirations to youth effectively. This is of particular interest and import to be examined in Chinese families, given Chinese cultural emphasis on educational achievement and Chinese youth’s outstanding academic performance internationally. By integrating several key theories of motivation and parental socialization (i.e., the expectancy-value model of academic achievement, the two-step model of value transmission, the contextual model of parenting, and the self-determination theory), the current study investigated simultaneously the mediating roles of parental involvement in youth’s learning and youth’s perceptions of parental aspirations, as well as the moderating role of parental warmth in the intergenerational transmission process of educational aspirations in Chinese families. A two-wave longitudinal study spanning about half a year was conducted among 323 Chinese seventh graders (54% female; Mage = 13.25 years) and one of their parents (median educational attainment = completion of high school, median monthly income = USD 766–1226). It was found that parental educational aspirations for youth were related positively both indirectly through parental involvement and directly to youth’s perceptions of parental aspirations, which in turn were associated positively with youth’s own educational aspirations about half a year later. It was also found that parental educational aspirations for youth and youth’s own educational aspirations were associated positively with each other only when youth reported experiencing high levels of parental warmth, but unrelated when youth reported experiencing low levels of parental warmth, whereas such moderating effects of parental warmth were absent on the links from parental aspirations to youth’s perceptions of parental aspirations and parental involvement. These findings highlight the importance of integrating multiple theories to understand parent-to-youth transmission of educational aspirations in non-western cultures, which helps not only reveal generalizability, as well as boundary conditions for Western-originated theories, but also inform practical endeavors at promoting youth’s educational achievement worldwide to draw on strengths of different cultures.

Peer relationship plays an important role in non-suicidal self-injury (NSSI). However, little is known about how and in what conditions peer relationship may influence NSSI. By integrating multiple theories (i.e., attachment theory, the emotional regulation model of self-compassion and NSSI, and the differential-susceptibility theory), the current study investigated two potential mediators (i.e., self-compassion and depressive symptoms) and one potential moderator (i.e., behavioral impulsivity) of the relation between peer acceptance and NSSI. Participants were 813 Chinese adolescents (43% female; Mage at Wave 1 = 13.15 years) from a two-wave longitudinal study with data spanning one year. The results revealed that the indirect pathways linking peer acceptance and NSSI were conditioned on the level of behavioral impulsivity. Specifically, for adolescents with lower levels of impulsivity, a higher level of peer acceptance was related to fewer depressive symptoms directly or indirectly through self-compassion; fewer depressive symptoms, in turn, were linked to fewer NSSI behaviors longitudinally. For adolescents with higher levels of behavioral impulsivity, peer acceptance was related to fewer NSSI behaviors only through self-compassion. Results indicate that increasing peer acceptance is important in reducing adolescent NSSI. Interventions designed to reduce adolescent NSSI may also be effective if they focus on promoting adolescent self-compassion, particularly for adolescents with higher levels of behavioral impulsivity.

Nanostructure and wettability present great potentials on high power electronics cooling. However, it is challenging to design optimal nanostructure for thermal management due to the mechanism of interaction between structure and wettability on boiling heat transfer which is not explicit. In this paper, a series of rough surfaces with different wettability were modeled to study the relationship between effects of nanostructure and wettability on rapid boiling. The simulation results showed that the increment of nanochannels height, which resulted in the enlargement of hydrophilic area, significantly promoted supply of liquid water and thermal energy transfer. What's more, potential energy and the density of water molecules on nanochannels zone were similar to that on hydrophobic zone, promoting nucleation points formation and evaporation. Based on those results, thermal design theory of optimized surface is established: big hydrophilic area, more nucleation points and potential energy difference of water molecules between hydrophilic zone and nucleation point are the key elements on surface designing. Thus, nanochannels with certain space and height were designed on a hydrophilic surface, which satisfied the optimization requirements, to enhance the nano heat transfer.

In this study, static contact angle measurement experiments were conducted on smooth copper surface and microchannel structure surfaces under different droplet sizes. The results showed that shallow processing will more easily lead to the deformation of the processed interface. And the wettability of the microchannel surfaces with the same width and different depth were obviously different. Moreover, the contact angles on three microchannel surfaces were almost the same when the size of droplet was 12μl duo to action of gravity. The optimal droplet size is 9μl to measure contact angle in this study.

This work aims to present theory of heat transfer on rapid boiling for pure wettability surfaces and mixed wettability surfaces based on molecular simulation. The simulation results showed that the temperature of water increased obviously and the maximum evaporation rate of water reduced significantly with the increase of hydrophilic for pure wettability surfaces. Furthermore, a microfluidic layer which was formed on all cases except hydrophobic surface (surface 4) was conducive to critical heat flux (CHF) improvement. Meanwhile, the attraction of water molecules upon hydrophobic region was smaller than that on hydrophilic region which was conducive to boiling heat transfer coefficient (HTC) improvement. A mixed wettability surface enhances boiling heat transfer by regulating vapor spreading behaviors over the heating copper surface compared with pure wettability surfaces.

Pemetrexed is an antimetabolite agent that inhibits multiple folate-requiring enzymes and is used in the treatment of mesothelioma and non-small-cell lung cancer. One of its toxicities is isolated cutaneous swelling affecting the eyelids and/or orbit. The pathologic assessment or its management has not been addressed to date. Herein, the authors report a case of a 77-year-old woman treated with pemetrexed for non-small-cell lung adenocarcinoma who developed persistent, severe bilateral lower eyelid swelling for several months, despite compresses and oral diphenhydramine. Elective excision was performed with good results and no recurrence after 6 months' follow up. Histopathologically, the excised tissue showed changes typical of dermatochalasis with dissolution of collagen and elastic bundles and marked dilation of lymphatic vessels. The combination of pre-existing, localized lymphatic failure and capillary leakage secondary to pemetrexed therapy can explain the onset and worsening swelling with successive rounds of chemotherapy.

The reaction of copper(II) salts with Bpy-TEMPO and Tpy-TEMPO (Bpy-TEMPO = [2,2′]Bipyridinyl-5,5′-dicarboxylic acid bis-[(2,2,6,6-tetramethyl-1-oxy-piperidin-4-yl)-amide]; Tpy-TEMPO = 2,2,6,6-tetramethyl-4-(2,2′:6′,2″-terpyridin-4′-yloxy)piperidin-1-oxyl) gave dinuclear Bpy-TEMPO-Cu2 (1) and mononuclear Tpy-TEMPO-Cu (2), respectively. The Cu(II) complexes were characterized by single crystal X-ray analysis. In 1, Cu(II) has a distorted square pyramidal coordination geometry, with a bridging chloride as the axial ligand. The Cu(II) core in 2 also exhibited a distorted square pyramidal coordination geometry, with one chloride as an axial ligand. Weak interactions such as π-interactions and hydrogen bonds are observed in both complexes. When applied as catalysts for the oxidation of benzyl alcohol to benzaldehyde in air, 1 exhibited higher activity than 2 for reactions in o-xylene at 60°C with DBU as a base. High yield (67%) of benzaldehyde was observed when using 1 as a catalyst in a solution of o-xylene with DBU at 60°C.

The wide need for sewage treatment facilities at the township level across China implies an emerging niche market for water and sanitation developers, investors and financiers. However this potential market is difficult to enter with traditional financing and delivery methods, because township sewage features small amount, volatile quantity, geographically scattering, immature fee charging system, weak affordability, and lack of capacities. A group of concession sewage treatment projects collectively implemented by a private company in the Changsha County of Hunan Province under the so called ‘Changsha Model’ provided innovative solutions. This cases study first examined the portfolio approach in terms of multiple delivery method integration, technology, and centralized control system, and evaluated the replicability of the new model. Practices and lessons learned from the case were then presented and summarized that can be applied to the following township sewage treatment facility development. Last, the Changsha Model was compared with similar infrastructure portfolio delivery solutions applied in the US.

Estramustine 600 mg/m2 can be administered safely with 225 mg/m2 of paclitaxel if administered as a 3-hr infusion for the treatment of hormone refractory prostate cancer. Significant anti-tumor activity has been reconfirmed despite the change in schedule of administration of the paclitaxel.This phase I study was conducted to identify the maximum tolerated dosage of paclitaxel administered as a 3-hr infusion combined with a stable dosage of estramustine capsules daily in men with hormone refractory prostate cancer. A secondary endpoint was to assess anti-tumor efficacy in this targeted patient population.Twenty-six male patients, all with hormone refractory prostate cancer were enrolled in this trial. Estramustine was administered at a dosage of 600 mg/m2 daily, and paclitaxel was dose-escalated in cohorts from 125 to 250 mg/m2 administered as an infusion over 3 hr every 21 days. Patients were treated until maximum response was achieved, or toxicity or progressive disease precluded further treatment. Toxicity to determine maximum tolerated dose was assessed only during the first 3-week cycle.The maximum tolerated dose of paclitaxel on this schedule was 225 mg/m2 based on unacceptable dose-limiting fatigue observed at the next higher dosage level. Other grade 3 or 4 events included myelosuppression, left ventricular dysfunction, elevated liver function tests, deep venous thrombosis, vomiting, and development of depression. Using a response criteria of prostate specific antigen decline of50% persisting for a minimum of 6 weeks, eight of 26 patients responded (30.8%). Two of seven patients with documented soft-tissue disease experienced50% reductions in size of lesions or number of sites. The median response duration was 6 months, and the median survival time was 16 months.The recommended phase II dose of paclitaxel is 225 mg/m2 when administered over 3 hr in combination with estramustine. This regimen has an acceptable toxicity profile, is a convenient schedule, and results in significant antitumor activity even in a heavily pre-treated population of patients.