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This study aims to empirically investigate the concept of information systems’ (IS) effectiveness and its relationship with organisational performance in Small and Medium-Sized Enterprises (SMEs). Based on a literature review, the study identifies three dimensions of IS effectiveness: technological context (system quality and information quality), organisational context (users’ IS knowledge, users’ IS involvement, and top management’s IS support), and environmental context (external expertise). Data were collected from 496 SMEs and analysed using structural equation modelling (SEM) with SmartPLS 4.The results indicate that system quality, top management support, and external expertise significantly influence organisational performance. Specifically, management involvement (β=0.098, p

Abstract Background Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens. Methods In a case-control study nested within a large sentinel hospital-based surveillance program in India, stool samples from 272 children aged less than 2 years admitted for intussusception and 272 age-, gender- and location-matched controls were evaluated with Taqman array card based molecular assays to detect enteric viruses, bacterial enteropathogens and parasites. Matched case-control analysis with conditional logistic regression evaluated association of enteropathogens with intussusception. Population attributable fractions (PAF) were calculated for enteropathogens significantly associated with intussusception. Results The most prevalent enteropathogens in cases and controls were enteroaggregative Escherichia coli, adenovirus 40/41, adenovirus C serotypes and enteroviruses. Children with intussusception were more likely to harbor adenovirus C serotypes (adjusted odds-ratio (aOR) = 1.74; 95% confidence interval (CI) 1.06–2.87) and enteroviruses (aOR = 1.77; 95% CI 1.05–2.97) than controls. Rotavirus was not associated with increased intussusception risk. Adenovirus C (PAF = 16.9%; 95% CI 4.7% − 27.6%) and enteroviruses (PAF = 14.7%; 95% CI 4.2% − 24.1%) had the highest population attributable fraction for intussusception. Conclusion Adenovirus C serotypes and enteroviruses were significantly associated with intussusception in Indian children. Rotavirus was not associated with risk of intussusception.

Aim: Today, vaccine hesitancy is one of the top 10 global health threats, which hinders adequate immunization coverage and herd immunity. The most recent global event that has led to a surge in vaccine hesitancy is the COVID-19 pandemic. COVID-19 vaccines have been studied extensively, but a sizable number of people continue to have misgivings towards COVID-19 vaccines. Materials and Methods: We performed a cross-sectional survey among adults across Tamil Nadu, India, to measure the frequency of vaccine hesitancy and to understand the factors contributing to it. Results: In our study population (n=1622), 49% were unwilling to get vaccinated. Hesitancy was higher among males when compared to females (54% vs. 41%) and among the older population when compared to the younger population (58% vs. 43%). The most preferred information sources regarding COVID-19 vaccines were television (38%), social media (25%), and newspapers (16%). Among the various social media platforms, WhatsApp was the most popular (33%), and Twitter was the least popular (2%). Half the population (52%) felt that herbal supplements were sufficient to provide immunity against COVID-19. The most common reason for hesitancy towards COVID-19 vaccination was the perception that the vaccine was not safe enough (52%). Conclusion: Our study shows that even after sufficient time had passed since the start of the pandemic, vaccine hesitancy in a progressive state such as Tamil Nadu was disturbingly high. This warrants the need for more efforts to educate the public about the necessity of vaccines.

Abstract Groundwater poisoning by heavy metals has caused serious health hazards in the exposed population globally. Manganese (Mn) poisoning causing human health hazards is very meagerly reported worldwide. The present research elucidates for the first time the catastrophic effect of manganese causing cancer in the Gangetic plains of Bihar (India). The blood samples of n = 1146 cancer patients were voluntarily obtained for the study, after their consent. Their household water samples were also collected for the study. All the samples were analysed for Mn contamination by Atomic Absorption Spectrophotometer. The study indicates high Mn contamination in the cancer patient blood samples with highest content as 6022 µg/L. Moreover, the cancer patient’s household handpump water samples also contained elevated Mn contamination. The correlation coefficient study finds significant association between Mn contamination in blood of cancer patients and their handpump water. The carcinoma group of cancer patients mostly in Stage III & IV had significant Mn contamination in their blood (above WHO/BIS permissible limit). The geospatial study depicts Mn contamination in handpump water in the state of Bihar in correlation with cancer patient’s blood samples. This novel finding is being reported in India for the first time, which correlates cancer with handpump drinking water. The long-term Mn exposure could be one of the causative agents for elevating cancer incidences. However, other confounding risk factors cannot be denied.

Entomophthoramycosis is a sporadic, slow-growing subcutaneous infection that includes two distinct clinical forms: Basidiobolus ranarum (subcutaneous) and Conidiobolus coronatus (Rhinofacial), common in tropical countries like India. A 20-year-old male presented with painless progressive swelling of the anterolateral aspect of the right thigh, with a history of Incision and Drainage (I&D) not responding to antibiotics. A clinical diagnosis of a soft-tissue tumour was made. Magnetic Resonance Imaging (MRI) showed a subcutaneous lesion with inflammatory changes and overlying skin changes. Core biopsy showed spindle cells. Surgeons proceeded with a wide local excision of the lesion. Histopathology {Haematoxylin and eosin (H&E), Grocott Methenamine Silver stain (GMS), Periodic Acid Schiff stain (PAS)} proved to be subcutaneous zygomycosis showing Splendore-Hoeppli phenomenon. The patient was then started on antifungal treatment followed by skin grafting. In the present case, the granulomatous inflammation was not picked up in multiple random core biopsies and hence, a wide excision was done, leading to an avoidable extensive surgery.

Abstract Groundwater arsenic poisoning has posed serious health hazards in the exposed population. The objective of the study is to evaluate the arsenic ingestion from breastmilk among pediatric population in Bihar. In the present study, the total women selected were n = 513. Out of which n = 378 women after consent provided their breastmilk for the study, n = 58 subjects were non-lactating but had some type of disease in them and n = 77 subjects denied for the breastmilk sample. Hence, they were selected for the women health study. In addition, urine samples from n = 184 infants’ urine were collected for human arsenic exposure study. The study reveals that the arsenic content in the exposed women (in 55%) was significantly high in the breast milk against the WHO permissible limit 0.64 µg/L followed by their urine and blood samples as biological marker. Moreover, the child’s urine also had arsenic content greater than the permissible limit (

The aim of the present investigation is to deal with integrals, which are connected with the extended generalized Mittag-Leffler function, Jacobi polynomial, and Bessel-Maitland function. Further, we are also considering the integral formulae, which involve various special functions. Interesting special cases of the main results are also considered. The results obtained here are general in nature and can presume numerous new integral formulae connecting the several types of polynomials.

Okra [Abelmoschus esculentus (L.) Moench] is an often cross-pollinated crop with up to 19–42% of cross pollination assisted by insects and planned pollination may improve the economic fruit yield and biological parameters. The present study was carried out during rainy (kharif) seasons of 2021 and 2022 at Research Farm of ICAR-Vivekananda Parvatiya Krishi Anusandhan Sansthan, Hawalbagh, Almora, Uttarakhand to assess the pollinator diversity and possible results (both biological and economical) of planned bee pollination. The study on floral visitors of okra recorded 28 insect spp. belonging to four insect orders, among which five spp., viz. Apis cerana indica (Fabricius) 1798, Apis mellifera (Linnaeus) 1758, Bombus haemorrhoidalis (Smith) 1852, Lithurgus atratus (Smith) 1853 and Xylocopa latipes (Drury) 1773 were predominant. The foraging activity and pollination behaviour showed that two non-Apis bee species (X. latipes and B. haemorrhoidalis) were swift flyers and visited more numbers of flowers per unit time. It was noticed that, peak period of pollinator’s visitation was between 9.00–11.00 h accounting to 113.76±7.65 insects/m2/10 min, during which stigma receptivity and pollen germination were at its peak. Assessment of yield related parameters of insect pollinated flowers showed superior quality fruits with better capsule length (17.4–20.9 cm), capsule girth (6.56–7.84 cm), seeds/capsule (51.4–60.6), test weight of 100-seeds (7.05–8.38 g) and even the seed yield (1.86–3.04 tonnes/hectare) than closed control and hand pollination (emasculated and cross pollinated). In conclusion, ecological engineering of okra fields enhances the pollination rate and ultimately the yield and seed quality.

India is home to 11 % of the global urban population and is ranks as the second-largest urban system in the world. This study introduces a Heat Health Risk Index (HHRI) rankings for 37 major Indian cities with more than one million residents, using geospatial and socio-ecological data to identify potential heat health risk areas. In this study, the Otsu method was employed to determine the critical parameters in the heat health index, considering factors such as Land Surface Temperature (LST), solar radiation, population density, mean temperature, urban green cover, rainfall, specific humidity, and wind speed. All data values were standardized to a uniform scale (0–1) for comparability. The standardized values, integrated with the assigned weights, formed the HHRI. Results indicate that cities such as Chennai, Mumbai, Kolkata, and Ahmedabad, each with populations exceeding 10 million, are deemed less livable due to their high HHRI (>0.50). Both Chennai and Mumbai stand out with highest hazard index as 0.66, followed by Kolkata (0.62) and Ahmedabad (0.56). Cities that lack sufficient green spaces are often more vulnerable, display elevated risk levels, and have decreased adaptability. In contrast, cities such as Ludhiana, Theni, Amritsar, and Nabarangpur are perceived as the most livable, with a mean HHRI of 0.21, owing to their higher adaptive capacity and lower exposure. Overall, this study serves as a foundation for conceiving future perspective plans for existing urban and peri‑urban areas, compared to living standards within the realms of sustainability.

Background: Xenografts in immunodeficient mice play a pivotal role in testing novel anti-cancer treatments. Xenograft models expedite the drug discovery process, offering a cost-effective alternative to conventional animal models and providing essential data for clinical trials. We have followed the approach described by the Developmental Therapeutics Program of the National Cancer Institute (NCI), USA to investigate the therapeutic responses. Objectives: In this research, potentized preparations derived from biomaterial, referred to as nosodes, have exhibited promising effectiveness against cancer in laboratory experiments. This study seeks to further substantiate these findings by employing animal models. Method: Potentized preparations from category nosodes sourced from biomaterials of HIV, Cancer tissue, Hepatitis C and a combination underwent testing within the NCI's preclinical evaluation protocols using Xenograft models (HOP62). All the experimental mice were randomly assigned to one of six groups (n = 6), including vehicle and positive controls. These preparations were administered orally at a dosage of 0.1 ml, five days a week, over a four-week period. The mice were closely monitored at regular intervals for 32 days, with observations regarding changes in body weight, tumor volume, morbidity, and mortality. Relative tumor volume (RTV) was calculated as the tumor volume on the day of measurement divided by the tumor volume on day 1. Results: The groups treated with Hepatitis C 30c and HIV 100c nosodes have not shown effect with respect to Relative Tumor Volume (RTV). Evidence of significant tumor regression was observed for RTV on day 30 in groups treated with HIV nosode 30c (P = 0.002), and Cancer nosode 30c (P = 0.005). Percentage Survival was noted better in HIV nosode 30c treated group from day 25, however, in other groups survival percentage remained constant. Varied animal body weight in all groups was noted. Significant differences in tumor volume with respect to time in all treated groups were observed. Conclusion: Results are suggestive of tumor regression which is encouraging to undertake further clinical trials to explore the anticancer potential of HIV nosode and Cancer nosode.

A 54-year-old female presented with a recurrent mass in the right breast for eight months, associated with pain and discolouration of the skin for two weeks. Past history revealed a wide local excision of a tumour in the same breast 10 months ago, which was reported as a benign phyllodes tumour. Local examination revealed a bosselated mass of size 20×20×10 cm occupying all four quadrants of the right breast, along with another firm lump of size 3×3 cm in the lower inner quadrant. Magnetic Resonance Imaging (MRI) of the breast showed two separate lumps: the large lump involved all four quadrants of the right breast and was suggestive of malignant transformation of a recurrent phyllodes tumour-BIRADS V (Breast Imaging-Reporting and Data System), and another smaller lump was noted in the lower inner quadrant. A Tru-cut biopsy of the larger lesion was reported as a possibility of a phyllodes tumour with mild nuclear atypia. The total mastectomy specimen showed both solid and cystic areas with necrotic material, haemorrhagic fluid, and blood clots in the larger lump. A separate lump from the lower inner quadrant of the ipsilateral breast showed a firm, solid lesion. Microscopic examination of both lesions revealed the simultaneous presentation of a malignant phyllodes tumour with chondrosarcomatous differentiation and infiltrating ductal carcinoma. This case highlights the unpredictable co-existence of two separate malignant lumps in the ipsilateral breast, which is an extremely rare event.

Introduction: Diabetes mellitus is a major public health problem in India. A Diabetic Foot Ulcer (DFU) is characterised by a full-thickness wound, skin necrosis, or gangrene below the ankle brought on by peripheral neuropathy or peripheral artery disease in diabetic patients. Numerous classification schemes have been put forth to classify and forecast the clinical outcomes of DFUs. The Perfusion, Extent, Depth, Infection and Sensation Score (PEDIS) classification system was developed to objectively categorise and define DFUs, facilitating communication between healthcare providers. Aim: To determine the utility of the PEDIS score in predicting the outcomes of patients with DFUs. Materials and Methods: The present single-centre prospective cohort study was conducted in the Department of General Surgery, Tezpur Medical College and Hospital, Tezpur, Assam, India, from August 1, 2022 to January 30, 2023, involving 60 patients. A PEDIS score was calculated and recorded for each patient. Patients were then classified into low-score (0-7) or high-score (8-12) groups and followed-up for six months. Outcomes were categorised as healed, unhealed, amputated, or deceased. Categorical data were presented as percentages and compared using the Chi-square test. The Receiver Operating Characteristic (ROC) curve was utilised to determine the cut-off value. A p-value

Background: The measurement of androgens (testosterone and dehydroepiandrosterone sulfate (DHEAS)) remains standard for the evaluation of polycystic ovarian syndrome (PCOS) women. However, other early novel androgen markers, 5 alpha-dihydrotestosterone (DHT) and 11-ketotestosterone (11-KT), may open a separate path of measurement, which may be more potent. The study was conducted with the objectives to analyze the association of 11-KT and DHT with established markers and with the clinical profile of PCOS patients. Materials and Methods: A case–control study was conducted on 30 newly diagnosed cases of PCOS as per the Rotterdam criteria and 30 age-matched controls. The estimation of testosterone, DHEAS, 11-KT, and DHT was performed by the enzyme-linked immunoassay (ELISA) method. The assessment of biochemical and hormonal parameters was compared and correlated with 11-KT and DHT. Results: Compared to the controls, cases had significantly higher 11-KT (20.81 ± 3.53 vs. 15.83 ± 2.67 nmol/L, P < 0.0001) and DHT (154.39 vs. 71.02 pg/mL, P < 0.0001). 11-KT showed a significant positive correlation with total testosterone (TT) (r = 0.555) and DHEAS (r = 0.501). DHT also showed a significant positive correlation with TT (r = 0.487) and DHEAS (r = 0.52). Conclusion: In conclusion, novel androgen derivatives (11-KT and DHT) hold equivalent evidence for the evaluation of women with PCOS as they are raised in women with PCOS as compared to controls. Moreover, they show a good correlation with the standard markers currently used for PCOS.

Two porphyrin-based polymeric frameworks, SnP-BTC and SnP-BTB, as visible light photocatalysts for wastewater remediation were prepared by the solvothermal reaction of trans-dihydroxo-[5,15,10,20-tetrakis(phenyl)porphyrinato]tin(IV) (SnP) with 1,3,5-benzenetricarboxylic acid (H3BTC) and 1,3,5-tris(4-carboxyphenyl)benzene (H3BTB), respectively. The strong bond between the carboxylic acid group of H3BTC and H3BTB with the axial hydroxyl moiety of SnP leads to the formation of highly stable polymeric architectures. Incorporating the carboxylic acid group onto the surface of SnP changes the conformational frameworks as well as produces rigid structural transformation that includes permanent porosity, good thermodynamic stability, interesting morphology, and excellent photocatalytic degradation activity against AM dye and TC antibiotic under visible light irradiation. The photocatalytic degradation activities of AM dye were found to be 95% by SnP-BTB and 87% by SnP-BTC within 80 min. Within 60 min of visible light exposure, the photocatalytic degradation activities of TC antibiotic were found to be 70% by SnP-BTB and 60% by SnP-BTC. The enhanced catalytic photodegradation performances of SnP-BTB and SnP-BTC were attributed to the synergistic effect between SnP and carboxylic acid groups. The carboxylic acid connectors strongly resist the separation of SnP from the surface of SnP-BTB and SnP-BTC during the photodegradation experiments. Therefore, the high degradation rate and low catalyst loading make SnP-BTB or SnP-BTC more efficient than other reported catalysts. Thus, the present investigations on the porphyrin-based photocatalysts hold great promise in tackling the treatment of dyeing wastewater.

Background: Epilepsy and psychogenic non-epileptic seizures (PNES) are both common disease entities and psychiatric comorbidities are also high among the sufferers. Studies on the comparison of the levels of comorbidities between the two groups are few in number. Aims and Objectives: The aims of this study were to investigate different psychiatric disorders like depression, anxiety, social functioning, and quality of life (QoL) in epilepsy and PNES patients and compare them statistically. Materials and Methods: 38 epilepsy and 22 PNES patients were evaluated with clinical history and different tools like the mini international neuropsychiatric interview - 5, Beck’s Depression Inventory - 2,state and trait anxiety inventory, Social and Occupational functioning scale for epilepsy and QoL in epilepsy - 31 questionnaire. Comparisons were made between the groups regarding sociodemographic data, scores on different aspects of psychiatric disorders, social functioning, and QoL. Results: The majority in the epilepsy group were males, and in the PNES group were females, while younger age group predominates in both groups. There was a high prevalence of depression and anxiety in both groups, while PNES subjects had significantly higher depression and trait anxiety scores. Social and occupational functions were comparable in the two groups, but QoL indexes were significantly worse in the PNES group. Conclusion: Findings in this study indicate that psychiatric comorbidities like depression and anxiety disorders are much more common among patients with epilepsy and PNES. Occurrence of depression is even higher among patients with PNES. Both epilepsy/PNES and these psychiatric comorbidities affect Socio-occupational functions and their QoL. Thus, it is very important to look for these psychiatric comorbidities and QoL in these patients and implement proper management protocols to improve their mental health as well as their QoL.

Background: A common emergency of the abdomen with a significant morbidity and fatality rate is gastrointestinal perforation. In the treatment of perforation, surgery is important. Scoring systems are required for prognosis, comparing, and auditing surgical procedures. Methods: A prospective study conducted at a single center with a sample of 100 individuals who had hollow viscus perforation was carried out. Investigations or a laparotomy were used to confirm the diagnosis. The death rate, anastomotic leak, dehiscence, infection, and respiratory issues, as well as hospital and intensive care unit stays were all followed prospectively over a 30-day period for all patients. Results: Duodenal perforation was the commonest among hollow viscus perforations. The 20–40 age range was the most severely affected. Males suffer more than females. Complications can be avoided with a correct early diagnosis and suitable treatment. The site, size, age, and number of perforations all affect the surgical method. P-POSSUM and APACHE II scores were strongly correlated with outcomes such as post-operative wound dehiscence, respiratory issues, ICU stay, and hospital stay. When predicting mortality, POSSUM score was found to be superior to MPI. Conclusions: Gastrointestinal perforations result in substantial morbidity and occasionally fatality. The most frequent reason for an acute abdomen requiring prompt, effective surgical intervention is hollow viscus perforation. Complications can be avoided with an accurate early diagnosis and sufficient treatment. The surgical strategy is determined by the perforation's location, size, age, and quantity.

Cargo terminals, as pivotal hubs of mechanical activities, maritime shipping, and land transportation, are significant sources of air pollutants, exhibiting considerable spatiotemporal heterogeneity due to the complex and irregular nature of emissions. This study employed a high-density air sensor network with 17 sites across four functional zones in two Shanghai cargo terminals to monitor NO and NO2 concentrations with high spatiotemporal resolution post sensor data validation against regulatory monitoring stations. Notably, NO and NO2 concentrations within the terminal surged during the night, peaking at 06:00 h, likely due to local regulations on heavy-duty diesel trucks. Spatial analysis revealed the highest NO concentrations in the core operational areas and adjacent roads, with significantly lower levels in the outer ring, indicating strong emission sources and limited dispersion. Employing the lowest percentile method for baseline extraction from high-resolution data, this study identified local emissions as the primary source of NO, constituting over 80% of total emissions. Elevated background concentrations of NO2 suggested a gradual oxidation of NO into NO2, with local emissions contributing to 32–70% of the total NO2 concentration. These findings provide valuable insights into the NO and NO2 emission characteristics across different terminal areas, aiding decision-makers in developing targeted emission control policies.

Vacuum impregnation (VI) is a novel, non-thermal treatment that aims to modify the composition of food material by partially removing water and air and impregnating it with physiologically active compounds without affecting the structural integrity of food matrix. Application of VI accelerates the mass transfer processes, which leads to few changes in food composition and improves dehydration. Large volumes in intracellular spaces of fruit and vegetable tissues make it suitable to introduce different agents like nutrients, cryoprotectants, browning inhibitors, enzymes, and chemicals; enhancing texture profile and inhibiting tissue softening, or compounds lowering water activity and pH. water activity Thus, the VI may help to achieve new product quality associated with physicochemical features and sensory attributes. This review highlights the evolution and mechanism of VI technique, major factors affecting VI of fruits and vegetables and their responses to processing, and industrial relevance. Vacuum impregnation consists ability to revolutionize various aspects of food processing and preservation. VI serves as a versatile tool that enhances the quality, shelf life, and nutritional content of processed fruits and vegetables. It offers unique advantages of altering product composition by introducing desired compounds while preserving structural integrity. VI improves mass transfer processes, reduces water content, enhances the absorption of nutrients, antioxidants, and preservatives. This technology finds application in producing fortified foods, extending shelf life, and creating innovative products with improved sensory attributes. VI's ability to efficiently impregnate substances into porous materials, combined with its energy-saving potential and compatibility with other processing methods, makes it a valuable tool in the food industry. As consumers demand healthier and long-lasting products, VI emerges as a promising solution for meeting market demands.

An experiments were conducted during 2021–22 at ICAR-Indian Agricultural Research Institute, New Delhi to study the impact of melatonin (MT) on key characteristics of guava (Psidium guajava L. cv. Barafkhana). Guava fruits were treated with different MT concentrations (200, 400, 600 and 800 μM) and stored at 10±1°C with 85–90% RH. The research revealed that treating with 600 μM MT notably decreased polyphenoloxidase activity by 57%, leading to delayed peel browning and also suppressed polygalacturonase (PG) activity by approximately 45% and pectine methylesterase activity by about 73%, resulting in higher firmness (5.33 N). Following a 20-days period of cold storage, significant reductions in electrolyte leakage, hydrogen peroxide accumulation and lipoxygenase activity were observed, thereby preserving cell membrane integrity. Additionally, MT stimulated the antioxidant defense system, boosted proline content accumulation, and enhanced phenylalanine ammonia-lyase activity. Together, these effects contributed to enhanced resistance against postharvest fungal decay (8.75%). In conclusion, MT at a concentration of 600 μM proves to be an effective postharvest treatment for maintaining texture, reducing fruit decay and extending the shelf-life of guava during cold storage.

Introduction: Acute bronchiolitis is a common viral respiratory illness with clinical features ranging from mild to severe forms, requiring intensive care management. Calcium, a micronutrient, plays a significant role in numerous intracellular and extracellular events. Vitamin D deficiency is known to be associated with respiratory infections, and vitamin D metabolism regulates serum calcium and Alkaline Phosphatase (ALP) levels. Thus, calcium levels may be the actual causative factor at the molecular level to determine the severity of respiratory infections. Aim: To estimate and compare serum calcium levels in infants with acute bronchiolitis and controls. Additionally, it aimed to investigate the effect of sunlight exposure on calcium levels in infants presenting at a tertiary care centre. Materials and Methods: A cross-sectional study was conducted from October 2004 to April 2006, over two consecutive years, among 446 infants in the paediatric unit of a tertiary care centre in Delhi, North India. A total of 223 infants (

Background: The majority of breast illnesses manifest as a palpable mass. The vast majority of breast lesions are not malignant, and the vast majority of benign lesions do not progress to cancer; however, the accuracy of diagnosis can be improved by a combination of preoperative tests such as physical examination, mammography, fine-needle aspiration cytology (FNAC), and Trucut needle biopsy (TCNB) or core needle biopsy (CNB). FNAC has gained in popularity and is now the primary treatment performed after a history and clinical examination to diagnose solid and cystic breast masses. This study was designed to assess the accuracy of FNAC in comparison to Triple Test and TCNB for the diagnosis of breast masses. Methodology: From January 2023 through May 2023, this study was conducted in the Tezpur Medical College and Hospital. The research included all female patients over the age of 20 with clinically palpable lumps. Palpable breast lumps need a complete clinical breast examination, imaging, and tissue sample for a clear diagnosis to rule out cancer.The Ultrasonography/Mammography, FNAC and tru-cut biopsy procedures were performed concurrently in the same region, and the results were compared to final histopathology as the gold standard. Result: The majority of the patients in the study were in age group of > 60 years. In our study Left breast was involved in 41 (58.5%) patients and right breast in 29 (41.4%) patients. The most frequent site involved was upper outer quadrant in 38 (54.2%). The overall sensitivity of FNAC in our study was 93.75%, tru-cut biopsy is 100% and that of triple test is 100% and specificity for malignancy was 91.6%, 93.6 and 95.6% for FNAC, tru-cut biopsy and triple test respectively. Conclusion: All three techniques have advantages and disadvantages. Core Needle Biopsy cannot be used in place of FNAC, and it is not required to identify all breast lesions. It can be utilised as an adjuvant in circumstances when cytology is definitive and biomarker tests are required. triple test and trucut were more accurate than FNAC in our testing.Trucut biopsy was able to provide histological diagnosis, and the findings were 100% consistent with the final histopathology report.

Plankton diversity plays an essential role in aquatic wetlands. Phytoplankton and zooplankton communities were assessed in three permanent water bodies: Petli (S1), Deva (S2) and Heranj (S3) of the Anand and Kheda districts. Sampling was done from December 2020 to March 2021. Collection of plankton and identification of planktons was done using various published plankton manuals. A total of 32 phytoplankton have been recorded during the study period, from which 36 % belong to class Chlorophyta, 32 % belong to class Bacillariophyta, 16 % belong to Cyanophyta, 10 % belong to Charophyte, 3 % belong to Dinophyta, and 3 % belong to Euglenophyta. In addition, a total of 27 zooplankton species have been found, from which 46 % belong to Maxillopoda, 23 % belong to Monogononta, 19 % belong to Branchiopoda, 8 % belong to Eurotatoria, and 4 % belong to Hexanauplia. S1 has the maximum number of phytoplankton (24), followed by S3 with 18 and S2 with 15 species. Zooplankton were at the maximum in S1 (19), followed by S2 with 16, and S3 with 11 species. Results of the present study indicate that the studied wetlands have rich plankton diversity.

[Sn(H2PO4)2(TPyHP)](H2PO4)4∙6H2O (2), an ionic tin porphyrin complex, was synthesized from the reaction of [Sn(OH)2TPyP] (1) with a dilute aqueous solution of a polyprotic acid (H3PO4). Complex 2 was fully characterized using various spectroscopic methods, such as X-ray single-crystal crystallography, 1H NMR spectroscopy, elemental analysis, FTIR spectroscopy, UV–vis spectroscopy, emission spectroscopy, EIS mass spectrometry, PXRD, and TGA analysis. The crystal structure of 2 reveals that the intermolecular hydrogen bonds between the peripheral pyridinium groups and the axially coordinated dihydrogen phosphate ligands are the main driving force for the supramolecular assembly. Simultaneously, the overall association of these chains in 2 leads to an open framework with porous channels. The photocatalytic degradation efficiency of methyl orange dye and tetracycline antibiotic by 2 was 83% within 75 min (rate constant = 0.023 min−1) and 75% within 60 min (rate constant = 0.018 min−1), respectively. The self-assembly of 2 resulted in a nanostructure with a huge surface area, elevated thermodynamic stability, interesting surface morphology, and excellent catalytic photodegradation performance for water pollutants, making these porphyrin-based photocatalytic systems promising for wastewater treatment.

A better understanding of the long-term safety, efficacy, and immunogenicity of COVID-19 vaccines is needed. This phase 3, randomized, placebo-controlled study for AZD1222 (ChAdOx1 nCoV-19) primary-series vaccination enrolled 32,450 participants in the USA, Chile, and Peru between August 2020 and January 2021 (NCT04516746). Endpoints included the 2-year follow-up assessment of safety, efficacy, and immunogenicity. After 2 years, no emergent safety signals were observed for AZD1222, and no cases of thrombotic thrombocytopenia syndrome were reported. The assessment of anti-SARS-CoV-2 nucleocapsid antibody titers confirmed the durability of AZD1222 efficacy for up to 6 months, after which infection rates in the AZD1222 group increased over time. Despite this, all-cause and COVID-19-related mortality remained low through the study end, potentially reflecting the post-Omicron decoupling of SARS-CoV-2 infection rates and severe COVID-19 outcomes. Geometric mean titers were elevated for anti-SARS-CoV-2 neutralizing antibodies at the 1-year study visit and the anti-spike antibodies were elevated at year 2, providing further evidence of increasing SARS-CoV-2 infections over long-term follow-up. Overall, this 2-year follow-up of the AZD1222 phase 3 study confirms that the long-term safety profile remains consistent with previous findings and supports the continued need for COVID-19 booster vaccinations due to waning efficacy and humoral immunity.

Ensuring a reliable water supply is critical for the success of Thailand’s Eastern Economic Corridor (EEC) Development Plan, a pivotal initiative aimed at boosting the country’s GDP. To address water limitations and high activity density in the pilot area, the EEC has implemented a policy to reduce water usage across all sectors, with a specific emphasis on the domestic sector. However, the complex nature of consumption patterns and diverse perspectives among domestic user present challenges to implementing effective top-down strategies for water management. This study employed a mixed-methods approach to investigate residents' and service sectors' perspectives on water management in the EEC. A questionnaire administered to 621 respondents, coupled with Principal Components Analysis, identified key factors influencing domestic water management: 1) the efficiency of water management and services, 2) community awareness and participation in addressing water issues, and 3) access to clean water services. The findings revealed that respondents perceived an unstable accessibility to clean water and services, coupled with low participation in water management. A notable inconsistency arose between respondents' perception of their water consumption and actual water use calculated from billing records, indicating an underestimation of their own water usage. With an average water consumption exceeding 200 L per capita per day, this poses a significant challenge compared to regional norms. In discussions with communities, participating in efficient water usage strategies was found to be more challenging than reduction-focused approaches. Moreover, there was a recognition and acceptance of wastewater recycling, contingent on water quality and appropriate usage objectives.

“Lifeline of the nation” is the motto of Indian Railways as it connects through a common thread, billion plus population in one way or the other. The National Rail Plan for India – 2030 focuses on creating a ‘future ready’ Railway system by 2030 by suitably integrating new railway systems like high-speed rails. However, rail infrastructure is exposed to multi-hazards and disasters sometimes disrupt safe rail operations. This study explores rail infrastructure risk assessment at a national scale utilizing the UNDRR framework and synthesized application of geospatial technologies with a focus on disentanglement of local vulnerabilities of the rail infrastructure assets utilizing factors of health of bridges, visibility obstruction to level crossings, labour wages & their regions and GSDP under multi-hazard scenarios. The results revealed that the NR and NFR were identified as high-risk routes under the risk analysis of physical and social vulnerability scenarios, followed by CR Railways. The average annual frequencies of emergency cases in each zone show a correlation r (17) = 0.4758 with the combined mean risk ranks for each zone. In comparison to socioeconomic factors, which contribute to indirect losses, physical factors directly affect safety and contribute to direct losses. Further, outcomes depict more accidents on Indian Railways during the monsoon (nearly 50%) and cold weather (29%) seasons. The study suggests that with the participation of key stakeholders, including urban and transport planners, an integrated approach is helpful in identifying critical rail routes towards risk-informed adaptive disaster-resilient infrastructure planning for providing safety, continuity and reliability of essential rail services.

Introduction: Trauma is the most common cause of mortality and morbidity in young individuals. Penetrating splenic injuries are more common than blunt injuries. The management of blunt splenic trauma has substantially evolved over the last few decades, moving from routine splenectomy to preserving the spleen wherever feasible. Aim: To determine the role of Multidetector Computed Tomography (MDCT) in the diagnosis and treatment of blunt splenic trauma. Materials and Methods: This hospital-based retrospective study was conducted in Department of General Surgery, Tezpur Medical College and Hospital, Tezpur, Assam, India. During the study period, there were 132 cases of blunt trauma abdomen. Among them, 122 patients had undergone MDCT of the abdomen. Clinical details of those 122 patients who did MDCT for possible blunt trauma of the abdomen were traced and were admitted to the Department of General Surgery, Tezpur Medical College and Hospital, Tezpur, Assam, India during the period from 1st October 2021 to 31st August 2022 retrospectively. The clinical data of these 122 patients were recorded. Of these 122 patients who underwent MDCT, 21 had splenic injuries. The patients who were treated conservatively were traced and the outcome of the treatment on follow-up, from the clinical notes. The preliminary MDCT findings of the patients were correlated with the final diagnosis and treatment. Fisher’s-exact tests and Chi-square were used for statistical analysis. Results: The 21 splenic injuries in this study were classified based on the American Association for the Surgery of Trauma (AAST) grading scales for organ injury, and 14 (66.67%) had Non Operative Management (NOM). Of the four patients with Contrast Material Extravasation (CME), all of them had undergone laparotomy related to the spleen (100%) and demonstrated active bleeding during surgery, but only three of the remaining 17 patients without CME (17.65%) required laparotomy related to the spleen; the difference was statistically found to be significant (p

Background: Sexual dysfunction (SD) is a common occurrence in Schizophrenia on antipsychotics, both typical and atypical. Indian studies in this regard are not many in number. Aims and Objectives: The aims of this study were to investigate SD in Schizophrenics on Trifluoperazine, Risperidone, and Olanzapine and also to evaluate the incidence of SD in relation to the duration of illness, duration of treatment, and dosage of the drugs in each group of subjects. Materials and Methods: In stable schizophrenic patients, on Trifluoperazine (n=40), Risperidone (n=40), and Olanzapine (n=40), SD was assessed using Arizona sexual experience scale. Demographic profile and duration of illness, duration of treatment and drug dosage were evaluated in each group. Comparisons were made between the incidence of SD between patients taking typical and atypical antipsychotics. Furthermore, distribution of SD with duration of illness, duration of treatment and dose of drugs were assessed in each group of subjects (taking Trifluoperazine, Risperidone, or Olanzapine). Results: (1) Majority of the subjects were males (66.67%) and above 30 years (55%). (2) Incidence of SD was higher with typical antipsychotics (statistically insignificant). (3) Increased duration of treatment and dose of drugs was associated with higher incidence of SD. Patients treated with Risperidone for longer duration and with Trifluoperazine with higher dose had higher incidence of SD (P

Transjugular intrahepatic portosystemic shunt (TIPS) is a nonsurgical intervention to reduce portal pressure by creating a low-resistance channel between the portal and systemic circulations. It is a well-accepted treatment for gastroesophageal varices and refractory ascites. This review aims to discuss the evidence-based applications of TIPS in other complications of portal hypertension beyond gastroesophageal varices and refractory ascites.

Kimura disease is an uncommon disease entity that typically involves the lymph nodes predominantly in the head and neck region together with frequent involvement of salivary glands. Very few cases of it have been reported in literature globally, and in the context of India, it is even rare. Early suspicion of Kimura disease may prevent the patient from unnecessary invasive diagnostic tests. We present a case scenario of a 35 years old female, from a hilly area who presented with painless neck swelling for 3 months that was followed by fever, new onset pain at the site of neck swelling, and skin rashes. Diagnosis of Kimura disease was made based on histopathological findings aided by peripheral eosinophilia and elevated serum Immunoglobulin E (IgE) levels. Following the diagnosis, the patient was treated with a short course of oral steroids which produced an excellent response with a consequent decrease in the size of lymph nodes and resolution of the skin rashes.

Abstract Nearly ~ 108 types of High entropy alloys (HEAs) can be developed from about 64 elements in the periodic table. A major challenge for materials scientists and metallurgists at this stage is to predict their crystal structure and, therefore, their mechanical properties to reduce experimental efforts, which are energy and time intensive. Through this paper, we show that it is possible to use machine learning (ML) in this arena for phase prediction to develop novel HEAs. We tested five robust algorithms namely, K-nearest neighbours (KNN), support vector machine (SVM), decision tree classifier (DTC), random forest classifier (RFC) and XGBoost (XGB) in their vanilla form (base models) on a large dataset screened specifically from experimental data concerning HEA fabrication using melting and casting manufacturing methods. This was necessary to avoid the discrepancy inherent with comparing HEAs obtained from different synthesis routes as it causes spurious effects while treating an imbalanced data—an erroneous practice we observed in the reported literature. We found that (i) RFC model predictions were more reliable in contrast to other models and (ii) the synthetic data augmentation is not a neat practice in materials science specially to develop HEAs, where it cannot assure phase information reliably. To substantiate our claim, we compared the vanilla RFC (V-RFC) model for original data (1200 datasets) with SMOTE-Tomek links augmented RFC (ST-RFC) model for the new datasets (1200 original + 192 generated = 1392 datasets). We found that although the ST-RFC model showed a higher average test accuracy of 92%, no significant breakthroughs were observed, when testing the number of correct and incorrect predictions using confusion matrix and ROC-AUC scores for individual phases. Based on our RFC model, we report the development of a new HEA (Ni25Cu18.75Fe25Co25Al6.25) exhibiting an FCC phase proving the robustness of our predictions.

Background: The pandemic resulted in increased screen hours in children due to virtual education. The rate of progression of myopia was noticed to be remarkable in the past 2 years. This study is an endeavor to study the effect of increased screen hours during COVID home confinement on the degree of progression of myopia in school children and to evaluate the difference in change of refractive errors with a variation in the screen size of the digital device used. Methods: This was prospective observational study with a retrospective comparison arm, wherein 70 school children (140 eyes) aged 4–18 years were subjected to a cycloplegic refraction test. The difference in spherical equivalent refraction from the year 2018 to 19 was compared with that of the difference observed in the pandemic year 2019–2020. A statistical analysis was also made regarding the correlation of variation in refraction between the different genders, age groups, and screen sizes. Results: Of the 70 children, 29 (41.42%) were girls and 41 (58.58%) were boys. The gadgets being used vary from mobiles to laptops, and the range of screens and sizes varies from 100 cm2 to 500 cm2. Similarly, the duration of device use varied from 4 to 8 h. For 2018, the mean value of the spherical equivalent was −1.69 ± 1.42, for 2019 it was −1.92 ± 1.50 and for 2020 the mean value was −2.61 ± 1.47 for the right eye. The mean value of the spherical equivalent for the left eye in 2018 was −1.68 ± 1.51, in 2019 the value was −1.87 ± 1.58, and in 2020, the mean value was −2.73 ± 1.78. Conclusions: Increased exposure to digital devices during the COVID-19 period has a role to play in the progression of myopia in school-aged children.

The use of artificial intelligence (AI) is an emerging technique in the early identification and categorisation of brain tumour. The currently used method, i.e., magnetic resonance image for the detection of tumour is a time–consuming and complex technique. In the newly developing technique using the AI, the magnetic resonance image scans are used as input data, whereas the currently used method reads the magnetic resonance image manually. The purpose of this article is that the use of novel technique seems very promising in the early detection of brain tumour with high sensitivity and specificity. In this article, two disciplines of AI – machine learning and deep learning are extensively discussed. Through the utilisation of AI techniques, the fields of medicine and health care have experienced remarkable advancements, still there is a shortage of knowledge on artificial–based methods for early tumour diagnosis and classification. In addition, the article discusses the future application of AI techniques in clinical studies.

Background: Many cases of multisystem inflammatory syndrome in children (MIS-C) are reported in post-COVID-19 cases. It is a serious complication of COVID-19, with a high mortality rate in low-income countries compared to high-income countries. This study was conducted to find out predictors of mortality in MIS-C. Subjects and Methods: In this prospective observational study, 81 children with MIS-C were enrolled. Detailed clinical features, laboratory parameters, treatment, and outcome of cases were recorded. After the determination of individual factors associated with mortality by univariate analysis, a binary logistic regression model of significant factors associated with mortality was developed. Results: Fever, breathlessness, conjunctivitis, and pain abdomen were major presenting complaints at admission. Fifty-seven (70.3%) were presented with shock, of which 31 (54.4%) had normotensive shock and 26 (45.6%) had hypotensive shock. There were 8 (9.8%) deaths in the study group. Association of pneumonia, acute respiratory distress syndrome, and acute kidney injury were significantly high among nonsurvivors. Levels of lactate dehydrogenase (LDH), interleukin-6, and prothrombin time (international normalized ratio) were significantly higher in nonsurvivors than survivors. On binary logistic regression, raised LDH and the use of a mechanical ventilator were found to be independent predictors of death (P < 0.05). Conclusions: Shock was the predominant manifestation in children with MIS-C. Raised LDH and the use of mechanical ventilators were found to be independent predictors of death in cases of MIS-C.

Immune checkpoint (IC) therapy has brought a huge revolution in the field of lung cancer treatment over the past decade. It has also revolutionised treatment paradigm and has tremendously improved patient prognosis. IC inhibitors (ICIs) targeting Programmed Cell Death Protein 1/Programmed cell death Ligand 1 (PD1/PD-L1) have shown remarkable success and are now being used as first-line therapies in metastatic disease, adjuvant therapy following surgical resection and chemotherapy in resectable disease. Despite this remarkable success, only a subset of patients obtains complete benefit and most patients do not respond or develop progressive disease during treatment. ICIs are relatively expensive and some patients suffer from significant immune-related adverse toxicities. Hence, the identification and discovery of new predictive and prognostic immunotherapy biomarkers remains the present crucial need for patient selection, stratification and also for guiding therapeutic decisions. Currently established biomarkers such as PD-L1 determined by immunohistochemistry and tumour mutation burden determined by next-generation sequencing are non-specific and possess limitations. At present, several other biomarkers using peripheral blood, liquid biopsies along with gene expression signatures, and tumour infiltrating lymphocytes are being researched globally which have demonstrated predictive potential to characterise ICIs responders. In this review, we provide a comprehensive overview of the current biomarkers, highlighting the main clinical challenges and possible novel potential biomarkers to better predict responders to ICIs.

The article presents the design and implementation of a hybrid fuzzy poisson fractional order proportional integral derivative controller (h-FL-PO-FPID controller) in the wind-driven permanent magnet synchronous generator (PMSG). The h-FL-PO-FPID controller is a hybrid controller that is formed by the combination of a fuzzy logic controller, a poisson distribution (PO), a fractional order proportional integral, and a derivative (FO-PID) controller. The integration of PMSG with the grid via rectifier and inverter has many challenges, like high peak overshoot, large settling time, more harmonics at the output end, and an inappropriate voltage profile. The total harmonic distortion (THD) is used to measure the harmonics. The PMSG is driven by a wind turbine. The rectifier & inverter controlling has been done with fuzzy logic controllers (FLC), FO-PID controllers, and proportional integral and derivative (PID) controllers. A closed-loop current control mechanism has been developed for controlling the rectifier and inverter with the given three methods. A tradeoff between complexity and time for computations of proposed controller provides optimal performance parameters. It is observed that peak overshoot (%) and settling time (sec) of the DC link voltage (5.1%,2.7 sec) and rotor speed (0.9 sec) are found to be minimum with h-FL-PO-FPID in comparison to FLC, FO-PID, and PID existing methods under various loading conditions. In addition to this, an improved voltage profile is obtained with h-FL-PO-FPID in comparison to other methods, which means the least THD (%) of the three-phase voltage is attained with h-FL-PO-FPID(3.1%) with respect to other and existing methods under various loading conditions.

Background: Sickle cell disease (SCD), sickle cell anemia (SCA), and sickle beta-thalassemia (SBT) are due to a mutated gene of hemoglobin (Hb), which makes the red blood cells sickle-shaped and decreases their oxygen-carrying capacity. The disease is prevalent in the rural population of Odisha. Clinical presentation of SCA and SBT is similar, though there is a difference in treatment modality for both the entities. However, there are a few studies to delineate between these two diseases in children below 15 years. Aim: A hospital-based prospective study was conducted in eastern India to assess the clinicohematological profile of children with SSA and SBT. Methods: The prospective study was conducted in Srirama Chandra Bhanja Medical College, Cuttack, Odisha, from January to December 2020. A total of 43 confirmed cases by Hb electrophoresis of SCD were enrolled. Detailed clinical manifestations and hematological and biochemical tests were recorded as per the pro forma. Results: Clinical findings validated the major manifestations of SCD as splenomegaly, hepatomegaly, jaundice, fever, abdominal pain, crisis, and myopathy. Most of the SCD patients have severe anemia (range; 2.7–12.4 g/dL) at presentation. Splenomegaly was found in 43.8% of SCA versus 85.2% of SBT cases. Jaundice was more marked in SCA (62.5%) compared to SBT (48.1%) cases. Both the mean corpuscular Hb and mean corpuscular volume are more in SCA compared to SBT. Conclusions: Presentation of SCA is more severe compared to SBT. Enhanced implementation of newborn screening programs in Odisha state will help in reduction of the disease burden and morbidity due to SCD.

Two structural isomeric porphyrin-based triads (Zn(II)porphyrin−Sn(IV)porphyrin−Zn(II)porphyrin) denoted as T1 and T2 were prepared from the reaction of meso-[5-(4-hydroxyphenyl)-10,15,20-tris(3,5-di-tert-butylphenyl)porphyrinato]zinc(II) (ZnL) with trans-dihydroxo-[5,10-bis(3-pyridyl)-15,20-bis(phenyl)porphyrinato]tin(IV) (SnP1) and trans-dihydroxo-[5,15-bis(3-pyridyl)-10,20-bis(phenyl)porphyrinato]tin(IV) (SnP2), respectively. All the compounds were characterized using UV–vis spectroscopy, emission spectroscopy, ESI−MS, 1H NMR spectroscopy, and FE-SEM. Most importantly, the two structurally isomeric porphyrin-based triads supramolecularly self-assembled into completely different nanostructures. T1 exhibits a nanosphere morphology, whereas T2 exhibits a nanofiber morphology. The amplified geometric feature in the structural isomeric porphyrin-based triads dictates the physical and chemical properties of the two triads. Both compounds showed the morphology-dependent visible light catalytic photodegradation of rhodamine B dye (74–97% within 90 min) and tetracycline antibiotic (44–71% within 45 min) in water. In both cases, the photodegradation efficiency of T2 was higher than that of T1. The present investigation can significantly contribute to the remediation of wastewater by tuning the conformational changes in porphyrin-based photocatalysts.

This study presents a GIS-based Multi-Criteria Decision Analysis (MCDA) spatial model to assess land suitability for oil palm (OP) cultivation in rainfed conditions. Initially, twelve parameters, viz., rainfall, number of rainy days, mean temperature, RH, ground water level, soil pH, salinity, soil depth, surface texture, stoniness, slope, and drainage, were selected for assessing OP suitability in one of the states (Kerala). However, subsequent ground verification revealed significant discrepancies, which prompted refining the model by focusing on key parameters with greater accuracy and relevance. Accordingly, only five the most critical parameters affecting OP cultivation under rainfed conditions were selected through the rank sum method, and weights were assigned ac-cording to their significance. This study was aimed at creating a comprehensive tool for informed decision making in agricultural planning. District-level spatial data from reliable sources were utilized for Multi-Criteria Decision Analysis. Thematic rasters, representing key factors influencing land suitability, were created in a GIS. Utilizing MCDA techniques, a digital suitability map was generated in ArcGIS 10.3, delineating three distinct classes over an extensive area of 10.5 million hectares. Further, with an aim to focus on actual locations that can be readily planted with oil palm, the suitable locations identified were restricted to eight selected land use/land cover (LULC) classes. This strategic limitation aimed to facilitate the expansion of OP cultivation exclusively to areas deemed most suitable based on the identified criteria. The validation of this developed model involved comparing the suitability map generated with the performance of existing oil palm plantations across diverse locations. The reasonable similarity between the model’s predictions and real-world plantation outcomes validated the effectiveness of this MCDA spatial model. This model not only helps identify suitable locations for rainfed oil palm cultivation but also serves as a valuable tool for strategic decision making in agricultural land use planning.

In this study, two distinct photocatalysts, namely tin(IV)porphyrin-sensitized titanium dioxide nanotubes (SnP-TNTs) and titanium dioxide nanofibers (TNFs), were synthesized and characterized using various spectroscopic techniques. SnP-TNTs were formed through the hydrothermal reaction of NaOH with TiO2 (P-25) nanospheres in the presence of Sn(IV)porphyrin (SnP), resulting in a transformation into Sn(IV)porphyrin-imbedded nanotubes. In contrast, under similar reaction conditions but in the absence of SnP, TiO2 (P-25) nanospheres evolved into nanofibers (TNFs). Comparative analysis revealed that SnP-TNTs exhibited a remarkable enhancement in the visible light photodegradation of model pollutants compared to SnP, TiO2 (P-25), or TNFs. The superior photodegradation activity of SnP-TNTs was primarily attributed to synergistic effects between TiO2 (P-25) and SnP, leading to altered conformational frameworks, increased surface area, enhanced thermo-chemical stability, unique morphology, and outstanding visible light photodegradation of cationic methylene blue dye (MB dye). With a rapid removal rate of 95% within 100 min (rate constant = 0.0277 min−1), SnP-TNTs demonstrated excellent dye degradation capacity, high reusability, and low catalyst loading, positioning them as more efficient than conventional catalysts. This report introduces a novel direction for porphyrin-incorporated catalytic systems, holding significance for future applications in environmental remediation.

An experiment was conducted to find out the effects of various postharvest treatments on the biochemical and bioactive compounds of custard apple cv. Balanagar fruits. In the present experiment, three chemicals viz. oxalic acid (OA) (2.5 mM, 5.0 mM, 7.5 mM, and 10 mM; salicylic acid (SA) (0.5 mM, 1.0 mM, 1.5 mM, and 2.0 mM) and Sodium Nitro Prusside (SNP) at 0.5 mM, 1.0 mM, 1.5 mM, and 2.0 mM along with control were applied. Fruits were stored at ambient condition (Temp. 25 ± 2°C and relative humidity (RH) 44 ± 2%). Results indicated that fruits treated with SNP (2.0 mM) had significantly (p≤ 0.05) higher total soluble solids (30.80°B), titratable acidity (TA) (0.33%) and retained higher total sugar content (TS) (25.09%) at the end of the 9th day of storage. At the end of storage, the least reduction in total phenol content (TPC) (492.52 mg gallic acid equivalent (GAE)/100 g (11.62%) was found in SNP (2.0 mM) treated fruits. Likewise, SNP (2.0 mM) significantly (p≤ 0.05) retained higher ascorbic acid (AA) (43.20 mg/100 g), antioxidant activity (AOX) (0.92 µmol Trolox Equivalent (TE)/g), total flavonoids (TF) (71.49 µg CE/100 g) and tannin content (TC) (1.28 mg/g) compared to control during 9 days of storage. Thus, in the present investigation, SNP treatment was most suited to preserve the nutritional quality and bioactive compounds.

[Sn(OSO3)2(TPyHP)](HSO4)2∙8H2O (1), an ionic Sn(IV)-porphyrin complex, was prepared by reacting [Sn(OH2)2TPyP] with dilute sulfuric acid. X-ray structural analysis revealed that the zwitterionic [Sn(OSO3)2TPyHP]2+ species consists of two anionic axial Sn–O–SO3 units and four peripheral pyridinium moieties, with an overall dicationic charge balanced by two hydrogen sulfate (HSO4−) counter-anions. Ionic hydrogen bonding between the oxygen atoms of axial sulfato ligands and the peripheral pyridinium groups of adjacent Sn(IV)-porphyrin cations led to the formation of a 1D channel filled with counter-anions and water molecules. The supramolecular self-assembly of 1 was further characterized using various spectroscopic techniques, including 1H NMR spectroscopy, elemental analysis, ESI-mass spectrometry, UV-vis spectroscopy, fluorescence spectroscopy, FT-IR spectroscopy, thermogravimetric analysis (TGA), and powder X-ray diffractometry. The zwitterionic [Sn(OSO3)2TPyHP]2+ complex is a structurally well-defined complementary scaffold involved in supramolecular self-assembly. This novel class of ion-assembled metalloporphyrin is a potential functional porphyrin material used in ion exchange applications.

A seroprevalence and molecular study was carried out in six districts of the state of Rajasthan, India to detect brucellosis in major livestock species. This study involves the testing of 3,245 livestock samples using the Rose Bengal Plate Test (RBPT), Indirect Enzyme-Linked Immunosorbent Assay (i-ELISA), and genus-specific polymerase chain reaction (PCR) markers for molecular diagnosis of the disease. In the tested samples, seroprevalence was 5.06% (CI: 1.96–8.15) using the RBPT test and 6.88% (CI: 1.98–11.78) using the i-ELISA test, while the cumulative seroprevalence (RBPT and i-ELISA) was 3.63% (CI: 0.44–6.83). The prevalence of the disease was 1.27% (CI: 0.56–3.11) when tested using molecular markers. The highest prevalence of brucellosis was detected in Cattle (7.00, 3.22%), followed by camels (5.50, 2.50%), buffalo (2.66, 0.00%), sheep (2.43, 0.41%), and goats (0.58, 0.23%) when serological (cumulative) and molecular diagnosis were considered preferred methods of detection. Cattle (3.22%) and camels (2.50%) also showed a high prevalence of disease when tested using molecular markers. The results of this study reveal that cattle, camel, and sheep brucellosis is prevalent in the study areas.

Jamun fruit, a member of the Myrtaceae family, is commercially grown in tropical and subtropical areas of the world for its fruits with sweet, sour, and astringent luscious flesh. Seeds of jamun fruits are discarded as trash during the industrial processing of fruit pulp into beverages, jellies, jam, vinegar, wine, and squash. These seeds are a potential source of bioactive compounds including hydrolysable tannins, phenolic acids, flavonoids, other phenolics, terpenoids, phloroglucinol derivatives and saponins, which have been endorsed several biological activities, such as antidiabetic, anticancer, anti-inflammatory, antioxidant, antimicrobial, antihyperlipidemic and antihypercholesterolemic, as well as cardioprotective, hepatoprotective and neuroprotective properties. High contents of carbohydrates, dietary fiber, minerals, and ascorbic acid have also been found in jamun seeds. However, potential utilization of these seeds as innovative implements for health benefits has not yet been fully understood. We aim to compile scientific research and recent advances on jamun seed nutritional profile, bioactive compounds composition, bioactive properties, and their potential as an ingredient in functional food formulation.

Economic growth has been a central issue of all governments and therefore numbers of studies have focused on identifying the factors affecting economic growth. This issue is more important in developing countries context that faces additional challenge of maintaining macroeconomic stability. In other words, the challenge they normally faced is attaining high and consistent production growth with low inflation. Keynesian concept of macroeconomic stability advocates maintaining external and internal balance with low inflation in order to achieve full employment and a stable economy. Particularly after the establishment of a new international monetary system that replaced gold standard and introduced the Bretton Woods system in 1970s (where U.S. dollar became the global currency), most economies experienced high inflation and low economic growth (Bhatta, 2015). This anomaly further strengthened the need of research to investigate the relationship between these two important macroeconomic variables i.e., to test the hypotheses whether there exists an inverse relationship between inflation and growth. This also therefore required answering the question at what levels should the inflation rate be constrained so that it does not start retarding the growth rate?

Background: Successful outcome of obstetric well-being is to assess by obtaining healthy mother and child in modern obstetrics. Assessment of fetal well-being is important in timely diagnosis of fetal compromise and management. Amniotic fluid serves a major role in the development of the fetus. Aims and Objectives: The present study aims to evaluate the oligohydramnios pregnancies admitted in IPD of G & O, Bankura Sammilani Medical College & Hospital in terms of intrauterine growth restriction (IUGR) and perinatal outcomes. Materials and Methods: The study was conducted at Bankura Sammilani Medical College and Hospital, West Bengal, in terms of IUGR and perinatal outcomes from April 2020 to September 2021 among 80 antenatal mothers diagnosed to have oligohydramnios and subsequently admitted in-patients-department. Thorough history taking and clinical examination was done. Template was generated in MS Excel sheet and analysis was done on SPSS software. Results: Among 80 antenatal mothers diagnosed with oligohydramnios, the mean age of patients was 22.0750±4.1484. 21 (26.25%) patients had NICU admission and 56 (70.0%) patients had IUGR. In the study, 1 (1.25%) patient was perinatal death and 79 (98.75%) patients survived. In without IUGR, the mean birth weight (mean±SD) of patients was 2.7483±0.2222. In without IUGR, 1 (4.2%) patient had NICU admission. In with IUGR, 20 (35.7%) patients had NICU admission. Conclusion: Ultrasonography plays a major role in early diagnosis of IUGR. IUGR was associated with cesarean section for fetal distress, and NICU admission among oligohydramnios can be predicted using umbilical artery Doppler velocimetry.

Abstract Background End stage renal disease (ESRD) is emerging as a major health issues across developing countries with limited access and awareness about the importance of exercises in daily life. People on prolong hemodialysis has difficulty in performing their activities of daily living (ADL). Loss of muscle mass is inevitable among patients on hemodialysis that leads to morbidity and mortality. Exercise is feasible during dialysis and can enhance quality of life. Increase in aerobic endurance by various combined protocol of aerobic and resistive exercises can improve compliance to regular exercise that underlines the theme of present study. Methods A total of 31 participants were recruited during November 2019 to February 2020, after screening of 65 participants for selection criteria from Indraprastha Apollo Hospital’s dialysis unit. The average age of the participants was 52.36 ± 11.56 years. A single-blinded, pre-test–post-test quasi-experimental clinical trial for intradialytic exercise program involving lower limb ergometer and resistance training for lower limbs and non-fistula hand for 24 sessions, in 3 months, twice a week was conducted. Results The exercise program was well tolerated and all patients completed it. Aerobic and resistance intradialytic exercises (IDE) had a positive effect on maximal oxygen consumption (VO2 Max), quality of life (SF 36), and sleep quality (PSQI). IDE showed statistically significant difference from pre- to post-intervention for maximal oxygen consumption, quality of life boosting their sleep quality. Conclusions IDE found to benefit the patient and results showed a significant improvement in maximal oxygen consumption, sleep quality, quality of life and fatigue over a span of 12 weeks. Trial registration CTRI, CTRI/2019/08/020848 . Registered on 22 August 2019.