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6. A Radiomic-Based Machine Learning System to Diagnose Age-Related Macular Degeneration from Ultra-Widefield Fundus Retinography

Author

Interlenghi, Matteo, primary, Sborgia, Giancarlo, additional, Venturi, Alessandro, additional, Sardone, Rodolfo, additional, Pastore, Valentina, additional, Boscia, Giacomo, additional, Landini, Luca, additional, Scotti, Giacomo, additional, Niro, Alfredo, additional, Moscara, Federico, additional, Bandi, Luca, additional, Salvatore, Christian, additional, and Castiglioni, Isabella, additional

Published
2023
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7. Biofeedback Training after Successful Inverted Internal Limiting Membrane (ILM)-Flap Technique for High Myopic Macular Hole

Author

Sborgia, Alessandra, primary, Niro, Alfredo, additional, Pastore, Valentina, additional, Albano, Valeria, additional, Boscia, Giacomo, additional, Piepoli, Marina, additional, Di Pardo, Camilla, additional, Accurso Tagano, Lorenzo, additional, Zerbinati, Marta, additional, Landini, Luca, additional, Pignataro, Maria Grazia, additional, Petruzzella, Giovanni, additional, Donghia, Rossella, additional, Alqahtani, Abdullah S., additional, Coassin, Marco, additional, Dell’Omo, Roberto, additional, Boscia, Francesco, additional, Alessio, Giovanni, additional, and Sborgia, Giancarlo, additional

Published
2023
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10. Microperimetric evaluation and predictive factors of visual recovery after successful inverted internal limiting membrane-flap technique for macular hole in high myopic eyes.

Author

Sborgia, Alessandra, Boscia, Giacomo, Niro, Alfredo, Landini, Luca, Pastore, Valentina, Albano, Valeria, Piepoli, Marina, Donghia, Rossella, Dore, Stefano, Viggiano, Pasquale, Buonamassa, Rosa, Di Pardo, Camilla, Molfetta, Teresa, Coassin, Marco, Dell'Omo, Roberto, Boscia, Francesco, Alessio, Giovanni, and Sborgia, Giancarlo

Published
2023
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13. Table S1

Author

Niro, Alfredo

Abstract

Multiple linear regression model of CMT at 6 months after DEX-I and all variables together in the model.

Published
2023
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17. Correlation between retinal vessel rarefaction and psychometric measures in an older Southern Italian population

Author

Giuliani, Gianluigi, primary, Sborgia, Giancarlo, additional, Niro, Alfredo, additional, Castellana, Fabio, additional, Lampignano, Luisa, additional, Puzo, Pasquale, additional, Pascale, Angelo, additional, Pastore, Valentina, additional, Buonamassa, Rosa, additional, Galati, Roberta, additional, Bordinone, Marco, additional, Cassano, Flavio, additional, Clemente, Arcangelo, additional, Landini, Luca, additional, Scotti, Giacomo, additional, Gaudiomonte, Marida, additional, Guglielmi, Antonella, additional, Semeraro, Roberto, additional, Santoro, Michele, additional, Alessio, Giovanni, additional, Sardone, Rodolfo, additional, and Boscia, Francesco, additional

Published
2022
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18. Polyhexamethylene biguanide hydrochloride (PHMB)-properties and application of an antiseptic agent. A narrative review

Author

Niro, Alfredo, primary, Pignatelli, Francesco, additional, Fallico, Matteo, additional, Sborgia, Alessandra, additional, Passidomo, Fedele, additional, Gigliola, Samuele, additional, Nacucchi, Annalisa, additional, Sborgia, Giancarlo, additional, Boscia, Giacomo, additional, Alessio, Giovanni, additional, Boscia, Francesco, additional, Addabbo, Giuseppe, additional, Reibaldi, Michele, additional, and Avitabile, Teresio, additional

Published
2022
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23. Association of Neuroretinal Thinning and Microvascular Changes with Hypertension in an Older Population in Southern Italy

Author

Niro, Alfredo, primary, Sborgia, Giancarlo, additional, Lampignano, Luisa, additional, Giuliani, Gianluigi, additional, Castellana, Fabio, additional, Zupo, Roberta, additional, Bortone, Ilaria, additional, Puzo, Pasquale, additional, Pascale, Angelo, additional, Pastore, Valentina, additional, Buonamassa, Rosa, additional, Galati, Roberta, additional, Bordinone, Marco, additional, Cassano, Flavio, additional, Griseta, Chiara, additional, Tirelli, Sarah, additional, Lozupone, Madia, additional, Bevilacqua, Vitoantonio, additional, Panza, Francesco, additional, Sardone, Rodolfo, additional, Alessio, Giovanni, additional, and Boscia, Francesco, additional

Published
2022
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24. Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study.

Author

Lampignano, Luisa, Niro, Alfredo, Castellana, Fabio, Bortone, Ilaria, Zupo, Roberta, Tirelli, Sarah, Tatoli, Rossella, Griseta, Chiara, De Nucci, Sara, Sila, Annamaria, De Pergola, Giovanni, Conte, Caterina, Alessio, Giovanni, Boscia, Francesco, Sborgia, Giancarlo, Giannelli, Gianluigi, and Sardone, Rodolfo

Subjects
HEPATIC fibrosis, SCIENTIFIC literature, OPTICAL coherence tomography, OLDER people, LIVER diseases
Abstract

Background: Age is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study. Methods: Retinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A). Liver fibrosis risk was taken as the fibrosis-4 (FIB-4) score. Generalized linear models (logistic regression) were used to estimate the association effect between each unit increase of OCT and OCT-A parameters as independent variables and a FIB-4 ≥ 2.67 score as an outcome. Generalized additive models were used to assess the non-linear association between OCT-A features and the linear FIB-4 score. Results: Increased gangliar cell complex (GCC) thickness was inversely associated with a FIB-4 score above the cut-off in both the raw model (OR: 0.98; 95% CI: 0.96–0.99; SE: 0.01) and after adjustment for age, sex, education, hypertension, diabetes, total cholesterol, and triglycerides (OR: 0.98; 95% CI: 0.97–0.99; SE: 0.01). Conclusion: Our findings add to the growing volume of scientific literature demonstrating that liver fibrosis is associated with retinal neurodegeneration. This study raises a number of new questions, including whether OCT-A may be used to track the progression of metabolic abnormalities and define exact thresholds for predicting and classifying liver disease. [ABSTRACT FROM AUTHOR]

Published
2022
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26. DIABETIC MACULAR EDEMA AND CATARACT SURGERY

Author

Furino, Claudio, primary, Boscia, Francesco, additional, Niro, Alfredo, additional, D'Addario, Maria, additional, Grassi, Maria O., additional, Saglimbene, Valeria, additional, Reibaldi, Michele, additional, and Alessio, Giovanni, additional

Published
2021
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27. One-Handed Rotational Phacoemulsification Technique

Author

Gigliola, Samuele, primary, Sborgia, Giancarlo, additional, Niro, Alfredo, additional, Palmisano, Carmela, additional, Puzo, Pasquale, additional, Giuliani, Gianluigi, additional, Sborgia, Luigi, additional, Pastore, Valentina, additional, Sborgia, Alessandra, additional, and Alessio, Giovanni, additional

Published
2021
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28. Perfluorocarbon liquid-assisted inverted inner limiting membrane-flap for large macular hole after recurrent rhegmatogenous retinal detachment

Author

Niro, Alfredo, primary, Sborgia, Luigi, additional, D′Oria, Francesco, additional, Sborgia, Giancarlo, additional, Sborgia, Alessandra, additional, Furino, Claudio, additional, Giuliani, Gianluigi, additional, Ferrari, LuisaMicelli, additional, Boscia, Francesco, additional, Recchimurzo, Nicola, additional, and Alessio, Giovanni, additional

Published
2021
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31. Surgical Management of Complications after Dexamethasone Implant

Author

Sborgia, Giancarlo, Niro, Alfredo, D’Oria, Francesco, Galeone, Alessandra, Sborgia, Luigi, Boscia, Francesco, Sborgia, Alessandra, and Alessio, Giovanni

Subjects
Article Subject
Abstract

Purpose. To report surgical management of ocular complications occurred after dexamethasone (DEX) implant (Ozurdex®) injection. Methods. Retrospective interventional case series. Results. Different surgical procedures including viscoexpression to manage the migration of the implant into the anterior chamber, “phaco-rolling” technique for the intralenticular injection, and vitrectomy with implant removal for an acute endophthalmitis were performed. Successful management of different complications after DEX implant by using individualized surgical approaches was observed. Conclusions. Early and targeted surgical management is required in selected cases of ocular complications after DEX implant. The implant removal was needed to preserve ocular anatomy and function.

Published
2020
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33. Retinal Vascular Density on Optical Coherence Tomography Angiography and Age-Related Central and Peripheral Hearing Loss in a Southern Italian Older Population

Author

Sardone, Rodolfo, primary, Sborgia, Giancarlo, additional, Niro, Alfredo, additional, Giuliani, Gianluigi, additional, Pascale, Angelo, additional, Puzo, Pasquale, additional, Guerra, Vito, additional, Castellana, Fabio, additional, Lampignano, Luisa, additional, Donghia, Rossella, additional, Bortone, Ilaria, additional, Zupo, Roberta, additional, Griseta, Chiara, additional, Logroscino, Giancarlo, additional, Lozupone, Madia, additional, Giannelli, Gianluigi, additional, Panza, Francesco, additional, Boscia, Francesco, additional, Alessio, Giovanni, additional, and Quaranta, Nicola, additional

Published
2020
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34. Microperimetric Biofeedback Training After Successful Inverted Flap Technique for Large Macular Hole

Author

Sborgia, Giancarlo, primary, Niro, Alfredo, additional, Tritto, Tiziana, additional, Albano, Valeria, additional, Sborgia, Luigi, additional, Sborgia, Alessandra, additional, Donghia, Rossella, additional, Giancipoli, Ermete, additional, Coassin, Marco, additional, Pastore, Valentina, additional, Giuliani, Gianluigi, additional, Lorenzi, Umberto, additional, Romano, Mario R., additional, Boscia, Francesco, additional, and Alessio, Giovanni, additional

Published
2020
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37. Retinal Vascular Density on Optical Coherence Tomography Angiography and Age-Related Central and Peripheral Hearing Loss in a Southern Italian Older Population.

Author

Sardone, Rodolfo, Sborgia, Giancarlo, Niro, Alfredo, Giuliani, Gianluigi, Pascale, Angelo, Puzo, Pasquale, Guerra, Vito, Castellana, Fabio, Lampignano, Luisa, Donghia, Rossella, Bortone, Ilaria, Zupo, Roberta, Griseta, Chiara, Logroscino, Giancarlo, Lozupone, Madia, Giannelli, Gianluigi, Panza, Francesco, Boscia, Francesco, Alessio, Giovanni, and Quaranta, Nicola

Subjects
WORD deafness, OPTICAL coherence tomography, OPACITY (Optics), AUDITORY perception, RETINAL blood vessels
Abstract

Background: Age-related hearing loss (ARHL) and retinal vessel changes have both been associated to neurodegeneration/dementia, suggesting a possible link between these 2 conditions in older age. We aimed to determine whether superficial and deep vascular density (SVD and DVD) of the capillary plexi of macular vasculature can be associated with peripheral ARHL and age-related central auditory central processing (CAPD).Method: We analyzed data on 886 older participants (65 years+, age range: 65-92 years) in the cross-sectional population-based Salus in Apulia Study. Optical coherence tomography angiography was used to measure SVD and DVD of the capillary plexi of the macula at the 3-mm circle area centered on the fovea (whole retina), the parafoveal quadrant, and foveal quadrant. Disabling peripheral ARHL was defined as >40 dB hearing level of pure tone average on the frequencies from 0.5, 1, 2, and 4 KHz in the better ear, and age-related CAPD as <50% at the Synthetic Sentence Identification with Ipsilateral Competitive Message test in at least one ear.Results: DVD at the whole retina and at the parafoveal quadrant were inversely associated only with age-related CAPD (odds ratio [OR]: 0.93, 95% confidence interval [CI]: 0.88-0.96 and OR: 0.94, 95 CI: 0.90-0.99, respectively). No further associations with peripheral ARHL were evident.Conclusions: Retinal vasculature is associated with central auditory processing pathology, possibly playing an important role in early detection and intervention. The association of retinal vascular density with age-related CAPD may bring us a further step forward in understanding the biological mechanisms underlying the links between neurodegeneration/dementia and ARHL. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Perfluorocarbon liquid-assisted inverted inner limiting membrane-flap for large macular hole after recurrent rhegmatogenous retinal detachment.

Author

Sborgia, Luigi, Niro, Alfredo, D′Oria, Francesco, Sborgia, Giancarlo, Sborgia, Alessandra, Furino, Claudio, Giuliani, Gianluigi, Ferrari, Luisa, Boscia, Francesco, Recchimurzo, Nicola, and Alessio, Giovanni

Abstract

A 45-year-old Caucasian myopic woman with a severe vision impairment (20/320) in the left eye due to a macula-off rhegmatogenous retinal detachment (RRD) underwent vitrectomy with silicone oil tamponade followed by an inferior relaxing retinectomy with heavy silicone oil tamponade during the second procedure for recurrence of RRD due to proliferative vitreoretinopathy. Four weeks after the second surgery, visual acuity was 20/200 and the patient complained metamorphopsia in the same eye due to a large full-thickness macular hole. A perfluorocarbon liquid-assisted inverted inner limiting membrane-flap technique was performed. Visual acuity improved to 20/80 after closing of macular hole and partial recovery of outer retinal layers at 3 months from the last surgery. [ABSTRACT FROM AUTHOR]

Published
2021
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39. OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Author

Furino, Claudio, primary, Shalchi, Zaid, additional, Grassi, Maria Oliva, additional, Cardoso, Joao N., additional, Keane, Pearse A., additional, Niro, Alfredo, additional, Cicinelli, Maria Vittoria, additional, Reibaldi, Michele, additional, Boscia, Francesco, additional, Alessio, Giovanni, additional, and Pavesio, Carlos, additional

Published
2019
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40. Angio-OCT micro vascular markers and central auditory disorder as indipendent predictors of cognitive impairment in the Great Age Study population (P1.9-006)

Author

Sardone, Rodolfo, primary, Sborgia, Giancarlo, additional, Piccininni, Marco, additional, Battista, Petronilla, additional, Niro, Alfredo, additional, Giuliani, Gianluigi, additional, Puzo, Pasquale, additional, Pascale, Angelo, additional, Sborgia, Alessandra, additional, Griseta, Chiara, additional, Barulli, Maria Rosaria, additional, Didio, Cristina, additional, Grasso, Alessandra, additional, Castellana, Fabio, additional, Coppola, Francesco, additional, Lozupone, Tiziana, additional, Rucco, Roberta, additional, Lozupone, Madia, additional, Panza, Francesco, additional, Alessio, Giovanni, additional, Quaranta, Nicola, additional, and Logroscino, Giancarlo, additional

Published
2019
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42. Xen gel stent implant for persistent glaucoma after silicone oil removal

Author

Boscia, Francesco, Ferreri, Paolo, Sisto, Dario, Niro, Alfredo, Boscia, Giacomo, Scotti, Giacomo, Viggiano, Pasquale, Sborgia, Alessandra, Sborgia, Giancarlo, Giancipoli, Ermete, and Alessio, Giovanni

Abstract

Purpose To evaluate the effectiveness and safety of the XEN-Stent for managing unresponsive to medical therapy secondary glaucoma after silicone oil (SO) removal.Methods This retrospective chart reviewed 12 patients who underwent vitrectomy and SO endotamponade. They experienced intraocular pressure (IOP) elevation after SO removal despite taking the maximum tolerated glaucoma medication. Eleven eyes underwent an XEN-implant, while 1 underwent an XEN-implant with phacoemulsification/IOL implantation. The primary outcome was to achieve success criteria: IOP <18 mmHg and >20% IOP reduction without medication (complete success) or with medication (qualified success) and without a secondary IOP-lowering procedure. IOP, best-corrected visual acuity (BCVA), and the number of glaucoma medications (Glaucoma Medication Score-GMS) were recorded at baseline, 1 day, 1 week, 1 (M1), 3 (M3), 6 (M6), and 12 (M12) months postoperatively.Results Baseline characteristics included males percentage 66.6%, mean age of 61.8 ± 5.7 years, BCVA 0.69 ± 0.3 logMAR, IOP 30 ± 4.2 mmHg, and GMS 3.1 ± 0.5. There was a significant reduction in IOP by 14 ± 1.9 mmHg and GMS by 0.27 ± 0.6 at M12 compared to baseline (p < 0.01), but no significant change in BCVA (p = 0.21). Complete success dropped to 50% (M3), rising to 75% (M6, M12) after needling. Two patients achieved qualified success at M12. Needling was performed in 6 eyes, with 3 requiring a second procedure. Ex-PRESS was required in 1 eye. One eye experienced hypotony and hyphema, which resolved within a week.Conclusion XEN implant may be an initial treatment for persistent post SO removal glaucoma with minimal complications. Needling procedures can help maintain or restore surgical success.

Published
2024
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48. Bilateral Ischemic Retinal Vasculitis in Metastatic Cutaneous Melanoma Patient Treated with Dabrafenib and Trametinib: A Case Report.

Author

Niro, Alfredo, Recchimurzo, Nicola, Sborgia, Alessandra, Alessio, Giovanni, and Guida, Michele

Subjects
*BRAF genes, *MELANOMA, *VISION disorders, *OPHTHALMOSCOPY, *VASCULITIS, *DRUG side effects, *STEROIDS, *EYE hemorrhage
Abstract

The article presents a case study of a 45 year old woman who was suffering from BRAF mutant metastatic cutaneous melanoma and presented bilateral blurred vision. It notes that tests such as funduscopy showed focal hemorrhages and disc leakage. The diagnosis of drug-induced ischemic vasculitis was noted and hence drugs such as Dabrafenib and Trametinib were discontinued and steroid treatment was started.

Published
2018
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49. OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Author

Michele Reibaldi, Maria Vittoria Cicinelli, Zaid Shalchi, Claudio Furino, Joao Cardoso, Carlos Pavesio, Pearse A. Keane, Francesco Boscia, Alfredo Niro, Giovanni Alessio, Maria Oliva Grassi, Furino, Claudio, Shalchi, Zaid, Grassi Maria, Oliva, Cardoso Joao, N., Keane Pearse, A., Niro, Alfredo, Cicinelli, M, Reibaldi, Michele, Boscia, Francesco, Alessio, Giovanni, and Pavesio, Carlos

Subjects
Adult, Male, medicine.medical_specialty, genetic structures, Fundus (eye), Retina, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ophthalmology, medicine, Humans, Fluorescein Angiography, External limiting membrane, Retinal thinning, Plexus, White Dot Syndromes, medicine.diagnostic_test, business.industry, Acute posterior multifocal placoid pigment epitheliopathy, Multifocal Choroiditis, Retinal, Fluorescein angiography, eye diseases, medicine.anatomical_structure, chemistry, 030221 ophthalmology & optometry, sense organs, business, Tomography, Optical Coherence
Abstract

BACKGROUND AND OBJECTIVE: To describe retinal and choroidal findings in different stages of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). PATIENTS AND METHODS: Retrospective, noncomparative case series studied by fundus biomicroscopy, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain optical coherence tomographic (SD-OCT), and swept-source OCT angiography (SS-OCTA). RESULTS: Six eyes of three patients with bilateral APMPPE were included. FAF showed multifocal, branched patches of hyperautofluorescence with areas of hypoautofluorescence; FA disclosed early hypofluorescence, with late-phase hyperfluorescence; ICGA showed early and late-phase hypofluorescence. SD-OCT imaging revealed bilateral retinal thinning, external limiting membrane (ELM) disruption, and severe alteration of the photoreceptor-retinal pigment epithelium complex. SS-OCTA showed widespread multiple dark spots in the choriocapillaris in Cases 1 and 2. Rarefaction and voids in the vascular texture were also detected in the deep plexus, unlike in Case 3, where the lesions were smaller and earlier, suggesting that retina vasculature may be affected after the choriocapillaris obstruction. CONCLUSIONS: APMPPE may result from a distinct focal ischemia in the choriocapillaris, and OCTA allowed the authors to localize exactly all the placoid lesions and monitor the areas of absent fluid signal. [ Ophthalmic Surg Lasers Imaging Retina . 2019;50:428–436.]

Published
2019

50. Comparison of perioperative parameters in one-handed rotational phacoemulsification versus conventional phacoemulsification and femtosecond laser-assisted cataract surgery.

Author

Gigliola S, Sborgia G, Niro A, Palmisano C, Puzo P, Giuliani G, Sborgia L, Sisto D, Pastore V, Furino C, Donghia R, Sborgia A, Boscia F, and Alessio G

Abstract

Aim: To compare perioperative parameters of one-handed rotational phacoemulsification technique (one-handed phaco-roll) with each of other two techniques, "Divide et Conquer" and femtosecond laser-assisted cataract surgery (FLACS)., Methods: In this retrospective and comparative cohort study, eyes with uncomplicated cataract (nuclear density grade 2 to 3) treated routinely with one-handed phaco-roll ( n =23; Group 1) or "Divide et Conquer" ( n =23; Group 2) or FLACS ( n =23; Group 3) were enrolled. Intraoperative parameters including effective phaco-time (EPt), ultrasound time (USt), aspiration time, surgical time, phacoemulsification (phaco)-power, balanced salt solution (BSS) use, cumulative dissipated energy (CDE) were recorded and compared. Clinical outcomes including best corrected visual acuity (BCVA), corneal endothelial cell density (ECD), endothelial cell loss (ECL), central corneal thickness (CCT) and central macular thickness (CMT), were assessed and compared pre-operatively and at 1mo after surgery., Results: Aspiration and surgical time, and BSS used were lower in Group 1 ( P <0.01) than other groups. EPt, phaco-power and CDE were lower in Group 1 ( P <0.05) than Group 2 but not significantly different from Group 3. In Group 1, USt was lower ( P <0.05) than Group 2 but higher ( P <0.05) than Group 3. BCVA improved in all groups without significant difference between Group 1 and the other ones. No significant differences regarding all post-operative morphologic outcomes (ECD, ECL, CCT, CMT) were reported. No clinical complications occurred., Conclusion: One-handed phaco-roll seems to be less time-consuming than "Divide et Conquer" and FLACS and less energy-consuming than "Divide et Conquer". Furthermore, one-handed phaco-roll seems to have an equal safety profile compared to the other two techniques., (International Journal of Ophthalmology Press.)

Published
2021
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