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Your search keyword '"Nishida, Eisuke"' showing total 867 results
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867 results on '"Nishida, Eisuke"'

15. Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor–mediated enhancement of the MKP-IRF3 axis

Author

Negishi, Hideo, Matsuki, Kosuke, Endo, Nobuyasu, Sarashina, Hana, Miki, Shoji, Matsuda, Atsushi, Fukazawa, Keiko, Taguchi-Atarashi, Naoko, Ikushima, Hiroaki, Yanai, Hideyuki, Nishio, Junko, Honda, Kenya, Fujioka, Yoichiro, Ohba, Yusuke, Noda, Tetsuo, Taniguchi, Shun'ichiro, Nishida, Eisuke, Zhang, Yongliang, Chi, Hongbo, Flavell, Richard A., and Taniguchi, Tadatsugu

Published
2013

35. Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Author

Honjoh, Sakiko, Yamamoto, Takuya, Uno, Masaharu, and Nishida, Eisuke

Subjects
Caenorhabditis elegans -- Physiological aspects -- Genetic aspects -- Research -- Health aspects, Aging -- Physiological aspects -- Research -- Genetic aspects -- Health aspects, Insulin-like growth factor 1 -- Health aspects -- Genetic aspects -- Research -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Physiological aspects, Research, Genetic aspects, Health aspects
Abstract

Dietary restriction is the most effective and reproducible intervention to extend lifespan in divergent species (1). In mammals, two regimens of dietary restriction, intermittent fasting (IF) and chronic caloric restriction, have proven to extend lifespan and reduce the incidence of age-related disorders (2). An important characteristic of IF is that it can increase lifespan even when there is little or no overall decrease in calorie intake (2). The molecular mechanisms underlying IF-induced longevity, however, remain largely unknown. Here we establish an IF regimen that effectively extends the lifespan of Caenorhabditis elegans and show that the low molecular weight GTPase RHEB-1 has a dual role in lifespan regulation; RHEB-1 is required for the IF-induced longevity, whereas inhibition of RHEB-1 mimics the caloric-restriction effects. RHEB-1 exerts its effects in part by the insulin/insulin growth factor (IGF)-like signalling effect or DAF-16 in IF. Our analyses demonstrate that most fasting-induced upregulated genes require RHEB-1 function for their induction, and that RHEB-1 and TOR signalling are required for the fasting-induced downregulation of an insulin-like peptide, INS-7. These findings identify the essential role of signalling by RHEB-1 in IF-induced longevity and gene expression changes, and suggest a molecular link between the IF-induced longevity and the insulin/IGF-like signalling pathway., In an IF regimen, which has not been established in invertebrate model organisms, food is provided ad libitum to both control and experimental groups, but the experimental group is subjected [...]

Published
2009

39. The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response

Author

Inoue, Hideki, Hisamoto, Naoki, Jae Hyung An, Oliveira, Riva P., Nishida, Eisuke, Blackwell, T. Keith, and Matsumoto, Kunihiro

Subjects
Mitogens -- Research, Protein kinases -- Research, Oxidative stress -- Research, Biological sciences
Abstract

The Caenorhabditis elegans PMK-1 p38 mitogen-activated protein kinase (MAPK) pathway regulates the oxidative stress response through the Cap-N-Collar transcription factor SKN-1. The results delineate the Caenorhabditis elegans p38 MAPK signaling pathway leading to the nucleus that responds to oxidative stress.

Published
2005

42. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

Author

Toyoshima-Morimoto, Fumiko, Taniguchi, Eri, Shinya, Nobuko, Iwamatsu, Akihiro, and Nishida, Eisuke

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Fumiko Toyoshima-Morimoto [1, 2]; Eri Taniguchi [2]; Nobuko Shinya [3]; Akihiro Iwamatsu [3]; Eisuke Nishida (corresponding author) [1, 2] In vertebrate cells, the nuclear entry of Cdc2-cyclin B1 (MPF [...]

Published
2001
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44. Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock

Author

Akahi, Makoto and Nishida, Eisuke

Subjects
Cytochemistry -- Research, Protein kinases -- Physiological aspects, Circadian rhythms -- Effect of chemicals on, Genetic regulation -- Research, Mammals -- Genetic aspects, Biological sciences
Abstract

The MAP kinase cascade and its possible role in resetting the mammalian circadian clock are discussed in this research communication. The suprachiasmatic nucleus (SCN) is the primary timing center in mammals, but peripheral/ immortalized cells have a circadian clock as well. Induction of the circadian oscillation of gene expression is started by TPA treatment of NIH-3T3 fibroblasts. NIH-3T3 is inhibited by a MEK inhibitor. Prolonged activation of the MAPK cascade is sufficient to bring on circadian gene expression.

Published
2000

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