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11. Indonesian Biodiversities, from Microbes to Herbal Plants as Potential Functional Foods

Author

Surono, I S, Nishigaki, T, Endaryanto, A, and Waspodo, P

Abstract

Proceedings of Shinshu University International Symposium 2007 “Sustainable Agriculture and Environment:Asian Network”, L. plantarum IS-10506 is one of very potential probiotic bacteria isolated from dadih, an Indonesia traditional fermented milk. The mechanisms and involvement of Toll-like Receptor（TLR）2 and 4 in reducing allergic reaction by Lactobacillus plantarum IS-10506 probiotic in vivo through enhancement of the TH1 and Treg immune responses and forming a new TH1-TH2 equilibrium has been proved. Noni（Morinda citrifolia）, Buah Merah（Pandanus conoideus）and Extra Virgin Coconut Oil（EVCO,Cocos nucifera）are Indonesian indigenous herbal plants and have been focused on their usefulness as functional foods. Nutritional values and biological actions were studied. Scopoletin in Noni fruits plays a significant role in improving the blood rheology, and has remarkably strong quenching action of reactive oxygen species（ROS）. Buah Merah is rich in carotenoids, especially β-cryptoxanthin, a novel chemopreventive agent against lung cancers of heavy smokers and may prevent and/or improve post-menopausal osteoporosis. EVCO does not contain trans-fatty acids and is rich in medium-chain fatty acids and saturated fatty acids., Article, 信州大学農学部紀要. 44(1-2): 23-27 (2008)

Published
2008

22. de Haas-van Alphen Effect of Strongly Correlated f-Electron Systems under Pressure.

Author

Takashita, M., primary, Aoki, H., additional, Haworth, C. J., additional, Terashima, T., additional, Uji, S., additional, Terakura, C., additional, Matsumoto, T., additional, Uesawa, A., additional, Suzuki, T., additional, Settai, R., additional, Onuki, Y., additional, Sato, N., additional, Kunii, S., additional, Nishigaki, T., additional, Sugawara, H., additional, Aoki, Y., additional, and Sato, H., additional

Published
1998
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32. Enterovirus 68 in children with acute respiratory tract infections, Osaka, Japan.

Author

Kaida A, Kubo H, Sekiguchi J, Kohdera U, Togawa M, Shiomi M, Nishigaki T, Iritani N, Kaida, Atsushi, Kubo, Hideyuki, Sekiguchi, Jun-ichiro, Kohdera, Urara, Togawa, Masao, Shiomi, Masashi, Nishigaki, Toshinori, and Iritani, Nobuhiro

Abstract

Enterovirus 68 strains were detected in 14 specimens from children with respiratory tract infections and 1 specimen from a child with febrile convulsions during 2010 in Osaka, Japan. These strains had deletions in the 5' untranslated region and were genetically different from reported strains. This virus is associated with respiratory tract infections in Japan. [ABSTRACT FROM AUTHOR]

Published
2011
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36. Tumor markers in pleural effusion diagnosis.

Author

Tamura, Shinsuke, Nishigaki, Tetsuya, Moriwaki, Yuji, Fujioka, Hiroshi, Nakano, Takashi, Fujii, Junji, Yamamoto, Tetsuya, Nabeshima, Kenji, Hada, Toshikazu, Higashino, Kazuya, Tamura, S, Nishigaki, T, Moriwaki, Y, Fujioka, H, Nakano, T, Fujii, J, Yamamoto, T, Nabeshima, K, Hada, T, and Higashino, K

Published
1988
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49. Biologically Active Oligodeoxyribonucleotides. 5.<SUP>1</SUP><BBR RID="jm970658wb00001"> 5‘-End-Substituted d(TGGGAG) Possesses Anti-Human Immunodeficiency Virus Type 1 Activity by Forming a G-Quadruplex Structure

Author

Hotoda, H., Koizumi, M., Koga, R., Kaneko, M., Momota, K., Ohmine, T., Furukawa, H., Agatsuma, T., Nishigaki, T., Sone, J., Tsutsumi, S., Kosaka, T., Abe, K., Kimura, S., and Shimada, K.

Abstract

A series of hexadeoxyribonucleotides (6-mers), d(TGGGAG), substituted with a variety of aromatic groups at the 5‘-end were synthesized and tested for anti-human immunodeficiency virus type 1 (HIV-1) activity. While unmodified d(TGGGAG) (31) had no anti-HIV-1 activity, compound 23 with a 3,4-di(benzyloxy)benzyl (DBB) group at the 5‘-end potently inhibited the HIV-1IIIB-induced cytopathicity of MT-4 cells in vitro (IC50 = 0.37 μM) without cytotoxicity up to 40 μM. A thermal denaturation study on the 5‘-end-substituted 6-mers by means of the circular dichroism (CD) spectra demonstrated that the aromatic substituent attached at the 5‘-end of the 6-mer strongly enhanced the formation of a parallel helical structure consisting of four strands (quadruplex). On the contrary, compound 36, in which one of the guanosines of 23 was replaced by a thymidine, did not form a quadruplex, thus exhibiting no anti-HIV-1 activity. Moreover, both compound 15, with a tert-butyldiphenylsilyl group solely at its 3‘-end, and compound 21, with a relatively small substituent, a benzyl group, at the 5‘-end, formed quadruplexes but had no anti-HIV-1 activity. These findings led us to the conclusion that both the quadruplex structure and the aromatic substituent with adequate size at the 5‘-end are crucial for the interaction of the 5‘-end-substituted 6-mers with the V3 loop as well as the CD4 binding site on viral gp120, resulting in anti-HIV-1 activity.

Published
1998

50. Regulation of in vitro and in vivo transcription of early-region IV of adenovirus type 5 by multiple cis-acting elements

Author

Hanaka, S, Nishigaki, T, Sharp, P A, and Handa, H

Abstract

A series of deletion mutants spanning the promoter of the adenovirus early-region IV (EIV) gene were tested for transcriptional activity, using both in vitro and in vivo assays. Four distinct domains had additive effects on efficient transcription from the EIV promoter in HeLa whole-cell extracts. The first resided 20 to 27 bases upstream of the initiation site and included the TATA box. Deletion of the TATA box drastically reduced the transcriptional activity in vitro but had a lesser effect in vivo. The second region extended from -32 to -177 and contained two 17-base-pair inverted repeats, centered around -40 and -162. Sequences lying between -140 and -173 were important for efficient transcription since deletion of this region reduced the activity fourfold. Deletion of either one of the two inverted repeats or insertion of DNA fragments between them resulted in the synthesis of extra transcripts that initiated at sites upstream from the EIV site. The third region was located between -198 and -250 and contains three guanosine-plus-cytosine-rich sequences, present around -212 (GGGCGG), -233 (GGGCGG), and -251 (CGCGGG). The fourth, most upstream region was located between -260 and -307. Deletion of this region, which contains the NF-1 factor-binding site, slightly reduced transcriptional activity both in vivo and in vitro. The data indicate that multiple cis-acting elements are required for efficient transcription from the EIV promoter in both in vitro and in vivo systems.

Published
1987
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