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Purpose: To assess the clinical effectiveness of immediate nonfunctional loading for single-tooth implants placed in the anterior maxilla following augmentation with cancellous freeze-dried block graft. Materials and Methods: The clinical outcomes of immediately nonfunctionally loaded implants up to 18 months after placement in the anterior maxilla were evaluated in 11 consecutive patients. Implants were immediately restored with unsplinted acrylic resin provisional crowns. Follow-up was monthly, and intraoral radiographs were obtained immediately after implant placement and at 6, 12, and 18 months. Survival rate and radiographic marginal bone loss were evaluated at 0, 6, 12, and 18 months. In the anterior maxilla, 12 implants were placed. Results: Marginal bone loss did not extend beyond the first thread up to 18 months follow-up, and the survival rate was 100%. Conclusion: Within the limits of the present study, immediate nonfunctional loading for single-tooth implants placed in the anterior maxilla following augmentation with cancellous freeze-dried block graft seems a promising treatment alternative. [ABSTRACT FROM AUTHOR]

PURPOSE: To assess whether splinting can counterbalance the detrimental effects of varying the crown-to-implant (C/I) ratio and crown height space (CHS) by decreasing nonaxial overload stresses. MATERIALS AND METHODS: Three implants were inserted into a photoelastic block model. Two strain gauges were cemented onto the neck of each implant on the buccal and lingual aspects and provided a simultaneous direct reading of strain. Four groups of splinted cement-retained restorations with C/I ratios of 1:1, 1:1.5, 1:1.75, and 1:2 were used. CHSs were 10, 15, 17.5, and 20 mm, respectively. Fifteen static loadings were carried out simultaneously with 20-kg weights via a custom-built loading apparatus at 30° to the vertical axis. RESULTS: Occlusal force application at 30° showed a statistically significant increase in both buccal (1,911.65 ± 110 vs 3,252.06 ± 150) and palatal (35.58 ± 7 vs 286.85 ± 15) microstrain values as the C/I ratio increased from 1:1 to 1:1.5 (P < .001). Force application at 30° in cases with C/I ratios of 1:1.75 and 1:2 resulted in fracture of the abutment screw followed by dislodgement of the crowns. Failures were noted at a CHS of 15 mm or greater. CONCLUSIONS: In this biomechanical mode, splinting does not prevent prosthetic failure when the CHS is 15 mm or greater. Vertical bone augmentation is highly recommended in cases with a CHS of 15 mm or greater. [ABSTRACT FROM AUTHOR]

PURPOSE: To review the published data on the treatment outcomes of restoring the partially edentulous patient with implant-supported removable partial dentures (ISRPDs) and describe the concept of ISRPDs and the clinical guidelines for placing implants for ISRPDs, and evaluate case series results. MATERIALS AND METHODS: For the review, a literature search was performed using the PubMed and Ovid databases. Reports in English from 1969 to 2008 were considered. Also, 35 patients have had their dentition restored with ISRPDs supported by 67 implants. These patients were evaluated in terms of implant and teeth survival. RESULTS: The data from the published reports and the presented case series suggest that the incorporation of dental implants into removable partial dentures could be an optional treatment plan for the partially edentulous patient to improve function and patient satisfaction. CONCLUSIONS: ISRPDs provide patients with stable, long-term predictable prostheses. This treatment alternative should be considered whenever fixed restorations are not a valid option. Strict maintenance and a follow-up protocol are recommended to obtain satisfactory results. Longitudinal clinical studies are required for evaluation of ISRPDs. Copyright © 2009 by the American Association of Oral and Maxillofacial Surgeons. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To compare the effect of endodontic access cavity location--labial versus palatal--on the resistance to fracture of maxillary incisors. METHOD AND MATERIALS: Sixty intact human maxillary incisors were selected: 20 pairs of central incisors and 10 pairs of lateral incisors. From each pair, 1 tooth was randomly selected to receive a palatal access cavity; the other tooth of the same pair received a labial access cavity. The teeth were divided into 4 test groups: group 1, central incisors with labial access; group 2, central incisors with palatal access; group 3, lateral incisors with labial access; and group 4, lateral incisors with palatal access. A lateral condensation technique was used to fill the canals with gutta-percha cones and AH-26 (Dentsply DeTrey). The access cavities were restored with hybrid resin composite. Specimens were mounted in a jig that allowed loading at the center of the palatal surface of the tooth, over the cingulum, at an angle of 130 degrees to the long axis of the tooth. Continuous compressive force at a crosshead speed of 2 mm/min was applied by an Instron universal testing machine. Load at fracture and mode of failure were recorded. Multiple analysis of variance (MANOVA) with repeated measures was used to statistically compare differences between groups at a significance of 5%. RESULTS: Mean failure loads for the 4 test groups were as follows: 894 N (group 1), 821 N (group 2), 774 N (group 3), and 705 N (group 4). No significant difference in failure load values was found among all tested groups (F = 0.5; P >.05). The mode of failure in all groups was an oblique radicular fracture, either at the level of the cementoenamel junction in 40% to 45% or at the root level in 55% to 60% of the teeth. CONCLUSION: Different endodontic accesses-labial or palatal-did not affect the failure resistance of maxillary incisors under simulated occlusal load. [ABSTRACT FROM AUTHOR]

PURPOSE: To prospectively evaluate the outcome of dental implants placed in the post-traumatic anterior maxilla after ridge augmentation with cancellous freeze-dried block bone allografts. MATERIALS AND METHODS: Patients presenting with a history of anterior dentoalveolar trauma with bony deficiencies in the sagittal (>=3 mm) and vertical (<3 mm) planes according to computed tomography were included. The recipient sites were reconstructed with cancellous bone block allografts. After 6 months of healing, implants were placed. The primary outcomes of interest were 1) bone measurements taken before grafting, at the time of implant placement, and at stage 2 operations; 2) implant survival; and 3) complications. RESULTS: The sample was composed of 20 consecutive patients with a mean age of 25 ± 7 years. We used 28 cancellous allogeneic bone blocks, and 31 implants were inserted. Of the 31 implants, 12 were immediately restored. The mean follow-up was 42 ± 15 months. Graft and implant survival rates were 92.8% and 96.8%, respectively. Mean bone gain in the sagittal and vertical planes was 5 ± 0.5 mm horizontally and 2 ± 0.5 mm (P < .001). Successful restoration was achieved in all patients with fixed implant-supported prostheses. Soft tissue complications occurred in 7 patients (35%). Complications after cementation of the crowns were seen in 3 implants (9.6%). All implants remained clinically osseointegrated at the end of the follow-up examination. There was no crestal bone loss around the implants beyond the first implant thread. CONCLUSION: Cancellous block allograft can be used successfully for post-traumatic implant-supported restoration in the anterior maxilla. [ABSTRACT FROM AUTHOR]

Background: Guidelines issued by professional organizations recommend that all patients with psychotic disorders who have had several psychotic relapses, continue maintenance anti-psychotic treatment. However, some patients discontinue anti-psychotics and do not later relapse. This study attempted to characterize those patients with psychotic disorders early in their disease not taking maintenance antipsychotics, who were not later hospitalized., Study Design: This population-based cohort study combined registry data on patients diagnosed in their first psychotic episode (ICD 10 code: F20-29) from Sweden (n = 20 848), and Israel (n = 10 045), and followed them for up to 7 years for re-hospitalization or death. Multivariate analyses assessed sociodemographic and clinical risk factors predicting rehospitalization or death in patients with one hospitalization and did not fill prescriptions for antipsychotics; results from Sweden and Israel were then meta-analyzed., Study Results: The main analysis of this paper included 1611 patients from Sweden and 1607 from Israel. Male gender (adjusted hazard ratio [aHR], 1.57; 95% confidence interval [CI], 1.16-2.13) and a diagnosis of narrowly defined schizophrenia (F20.0-F20.9; aHR, 1.85; 95% CI, 1.55-2.2) were associated with increased risk of a second hospitalization or death among those who did not use antipsychotics. No sociodemographic or clinical characteristics were associated with a decreased risk of a second hospitalization or death., Conclusions: Based on registry data, it was not possible to characterize, in a clinically meaningful way, those patients who can safely discontinue anti-psychotic medications and not be re-hospitalized or die. Male gender and a diagnosis of narrowly defined schizophrenia were associated with an increased risk of later relapse., (© The Author(s) 2025. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.)

Objective: In everyday dentistry, lithium disilicate is a valid option for single-fix partial dentures, and this material crystallization process is available with two protocols: long and short. This study's aim was to assess the effects of these two different crystallization protocols, long and short, on the marginal gap of lithium disilicate single crowns. Methods: A total of 24 abutment plastic teeth were scanned using an intra-oral scanner. For each plastic tooth, an identical pair of lithium disilicate crowns was milled (a total of 48 crowns) by a four-axis machine. Each paired sample was categorized into two groups: long crystallization (24 crowns) and short crystallization (24 crowns). To assess precision, each unit's marginal gap (including abutments and crowns) was meticulously measured at four specified regions using a scanning electron microscope. A Kolmogorov-Smirnov test performed on the study variables indicated a normal distribution ( p > 0.05), and it was followed by independent t -tests (α = 0.05). Results: For the long crystallization group, the mean total marginal gap values were 42.91 ± 9.67 μm, and for the short crystallization group, the values were 43.25 ± 8.14 μm, with no significant difference between the groups ( p = 0.894). In addition, no significant differences were found between the groups regarding the mean marginal gap measurements for all four surfaces (distal ( p = 0.310), mesial ( p = 0.732), palatal ( p = 0.655), and buccal ( p = 0.535)). Conclusions: Both the long and short crystallization methods used for lithium disilicate single crowns demonstrated marginal gap values of less than 120 μm, which are within the clinically acceptable range, with no significant differences across any parameters between the two groups. Regarding the marginal gap value, it is recommended to use the short crystallization protocol as it is more time-efficient.

Objective: This study was undertaken to explore the experiences and concerns of people living with epilepsy by analyzing discussions in an online epilepsy community, using large language models (LLMs) to identify themes, demographic patterns, and associations with emotional distress, substance use, and suicidal ideation., Methods: We analyzed 56 970 posts and responses to them from 21 906 users on the epilepsy forum (subreddit) of Reddit and 768 504 posts from the same users in other subreddits, between 2010 and 2023. LLMs, validated against human labeling, were used to identify 23 recurring themes, assess demographic differences, and examine cross-posting to depression- and suicide-related subreddits. Hazard ratios (HRs) were calculated to assess the association between specific themes and activity in mental health forums., Results: Prominent topics included seizure descriptions, medication management, stigma, drug and alcohol use, and emotional well-being. The posts on topics less likely to be discussed in clinical settings had the highest engagement. Younger users focused on stigma and emotional issues, whereas older users discussed medical treatments. Posts about emotional distress (HR = 1.3), postictal state (HR = 1.4), surgical treatment (HR = .7), and work challenges (HR = 1.6) predicted activity in a subreddit associated with suicidal ideation, whereas emotional distress (HR = 1.5), surgical treatment (HR = .6), and stigma (HR = 1.3) predicted activity in the depression subreddit. Substance use discussions showed a temporal pattern of association with seizure descriptions, implying possible opportunities for intervention., Significance: LLM analysis of online epilepsy communities provides novel insights into patient concerns often overlooked in clinical settings. These findings may improve patient-provider communication, inform personalized interventions, and support the development of patient-reported outcome measures. Additionally, hazard models can help identify at-risk individuals, offering opportunities for early mental health interventions., (© 2024 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)

Purpose: Assess whether a Retroaortic left renal vein (RLRV) affects vertebral osteophyte formation in the lumbar spine, compared to normal anatomy left renal vein., Methods: We conducted a retrospective case-control study. Computed tomography (CT) scans of individuals with a RLRV (study group) were compared to age- and gender-matched normal anatomy CT scans (control group). L1 to L4 vertebral levels were appreciated for: left renal vein level, osteophyte presence and the aorta-vertebral distance (AVD) at the left renal vein level. Univariate analyses were conducted using Chi-square test and Fisher's test for categorical variables, and Student's t-test for continuous variables. Logistic regression was used for multivariate analyses., Results: A total of 240 patients were included in the study - equally distributed between the study and control groups. Normal anatomy left renal veins traversed the spine only at the L1 and L2 levels. RLRVs traversed the spine in all L1-L4 levels, mostly at the L3 and L2. Osteophyte prevalence at the level of left renal vein was significantly higher in the study group, compared with the control group [OR 2.54, P = 0.01]. Mean AVD was greater in the study group [9.2 mm ±3.6 mm Vs. 3.5 mm ± 2.6 mm, P < 0.001]. Increased AVD was found to be associated with a higher chance of osteophyte presence at the level of the left renal vein [OR 1.282, P = 0.025]., Conclusions: Osteophytes are more prevalent at the level of the RLRV variant compared to the normal anatomy. Furthermore, the RLRV is characterized by a lower lumbar level compared to the normal anatomy., Clinical Relevance Statement: This anatomic variation could assist in further understanding of osteophyte formation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Background: The purpose of this pilot in-vitro study was to assess the effect of sterilization on the intra-implant axis, inter-implant axis, intra-implant distance and inter-implant distance of three implants in a straight line by using laboratory scanner (LBS) versus intra-oral scanner (IOS) with intra-oral scan bodies (ISB)., Methods: A printed 3D model with three internal hex analogs in the positions 15#,16#,17# was used. Zirkonzhan (ZZ) intra-oral scan body (ISB), two-piece titanium was used. The ZZ ISBs were scanned by 7 Series dental wings (LBS) and 30 times by Primescan (IOS) pre sterilization and 30 times post sterilization. For each scan (pre and post) stereolithography (STL) file was created and a comparison between all the scans pre sterilization and post sterilization were superimposed on the laboratory scan by using a 3D analyzing software. A Kolmogorov-Smirnov test performed followed by Wilcoxon Signed Ranks tests. (p < 0.05) Results: Post sterilization of the ZZ ISB, the mean errors were significantly increased for the inter-implant distances (p < 0.0005), intra-implant distances 1,2,3 (p < 0.0005), intra-implant axis 1,3 (p < 0.0005) and inter-implant axes 13,23 (p < 0.05). In contrast, the mean errors for intra-implant axis 2 (p < 0.0005) and inter-implant axis 12 (p < 0.0005) were significantly reduced., Conclusions: ZZ ISB showed changes in all four parameters after sterilization. The middle ISB had the largest changes in mean error regarding all four parameters. Sterilization process may affect the three-dimensional (3D) structure of the ZZ ISB after three cycles. There is a lack in the literature in this field and there is a need for further studies to explore the effect of sterilization (multiple cycles) on different ISBs and for creating an approved guidelines regarding the amount of sterilization for each ISB in the industry., (© 2024. The Author(s).)

Background : In everyday dentistry, monolithic single crowns can be cemented with self-adhesive resin cements. The aim of this in vitro study was to evaluate how the marginal adaptation of full monolithic zirconia-reinforced lithium silicate (ZLS) single crowns is influenced by three different self-adhesive resin cements. Methods : Forty-five typodont teeth fully prepared for full monolithic crowns were divided into three groups (fifteen each) for the use of three different self-adhesive resin cements. A fourth control group (Temp-bond) was created by taking five teeth from each group before cementation with self-adhesive resin cements. All forty-five abutments were scanned using a Primescan intra-oral scanner (IOS), followed by computer-aided design (CAD) and computer-aided manufacturing (CAM) of zirconia-reinforced lithium silicate (ZLS) full crowns using a four-axis machine. Initially, the crowns of the control group were fixed to the abutments using Temp-bond, and the marginal gap was evaluated using a scanning electron microscope (SEM). After removing the control group crowns from the abutments, fifteen crowns in each group were cemented using a different self-adhesive resin cement and observed under SEM for evaluation of the marginal gap. A Kolmogorov-Smirnov test was performed, indicating no normal distribution ( p < 0.05), followed by Mann-Whitney tests (α = 0.05). Results : The total mean marginal gap of the temp-bond control group was significantly lower compared to all three groups of self-adhesive resin cement ( p < 0.0005). The total mean marginal gap of the G-cem ONE group was significantly lower compared to the TheraCem group ( p < 0.026) and RelyX U200 group ( p < 0.008). The total mean marginal gap of the TheraCem group was significantly higher than the G-cem ONE group ( p < 0.026) but showed no significant difference with the RelyX U200 group ( p > 0.110). Conclusions : All four groups showed a clinically acceptable marginal gap (<120 microns). Although all three groups of self-adhesive resin cement showed a significant increase in the marginal gap compared to the temp-bond control group, they were within the limits of clinical acceptability. Regarding the marginal gap, in everyday dentistry, it is acceptable to use all three self-adhesive resin cements, although the G-cem ONE group exhibited the lowest marginal gap for ZLS single crowns.

This study aimed to compare the impact of CAD/CAM closed systems and open systems on the marginal gap of monolithic zirconia-reinforced lithium silicate (ZLS) ceramic crowns, as both systems are used in everyday dentistry, both chair-side and laboratory. For the closed system, 20 plastic teeth were scanned by a Primescan intra-oral scanner (IOS), and for the open system, the same number of plastic teeth were scanned by Trios 4 IOS. For the closed system, CEREC software was used, and for the open system, EXOCAD software was used. All 40 ZLS crowns were grinded by the same four-axis machine and cemented with Temp-bond, followed by self-adhesive resin cement. For each type of cement, an evaluation of the marginal gap was conducted by scanning electron microscopy (SEM). Before comparisons between the groups, a Kolmogorov-Smirnov test was performed on the study variables showing a normal distribution ( p > 0.05). Independent T tests (α = 0.05) and paired-sample T tests (α = 0.05) were used. The independent T test found no significant mean marginal gap differences in the zirconia-reinforced lithium silicate crowns bonded with Temp-bond and scanned by Primescan (28.09 μm ± 3.06) compared to Trios 4 (28.94 μm ± 3.30) ( p = 0.401), and there was no significant mean marginal gap differences in zirconia-reinforced lithium silicate crowns bonded with self-adhesive resin cement (Gcem ONE) and scanned by Primescan (46.70 μm ± 3.80) compared to Trios 4 (47.79 μm ± 2.59) ( p = 0.295). Paired-sample T tests showed significantly higher mean marginal gaps with Gcem ONE compared to Temp-bond for the total mean marginal gap when scanning with Primescan ( p = 0.0005) or Trios 4 ( p = 0.0005). In everyday dentistry, both closed systems (Primescan with Cerec) and open systems (Trios 4 with Exocad) can be used to achieve an acceptable (<120 µm) marginal gap for ZLS CELTRA ® DUO single crowns. There is a significant difference between cementation with Temp-bond and Gcem ONE self-adhesive resin cement ( p < 0.05).

Background : In this study, we aimed to compare the effects of conventional and digital impressions on several parameters (inter-implant distance, intra-implant distance, inter-implant axis, and intra-implant axis) of three implants in curved lines and straight lines by using a laboratory scanner (LBS) versus an intra-oral scanner (IOS). Methods : Two 3D models were fabricated using a printer, each model with three internal hex implants analogues at the positions of 15#,16#,17# (straight line) and 12#,13#,14# (curved line). Standard intra-oral scan bodies (ISBs) were used, and the two models were scanned using 7 Series dental wings (LBS, reference model), followed by ten scans with Primescan (digital method). Standard Tessellation Language (STL) files were created. Five polyether impressions were taken from each model (straight and curved), and gypsum type 4 models were poured; each model was scanned five times to create a total of 25 STL files for each group (conventional method). The comparison between all the STL files (conventional and digital) was made by superimposition of the STL files on the STL reference model laboratory file using a 3D analyzing software. A Kolmogorov-Smirnov test was performed, followed by Mann-Whitney tests and Wilcoxon signed-rank tests. ( p < 0.05). Results : For the conventional method, the mean errors were significantly higher for the curved line model (12-14) compared to the straight line model (15-17) for most parameters ( p < 0.05). For the digital method, the mean errors were significantly higher for the curved-line model (12-14) compared to the straight line model (15-17) in half of the parameters ( p < 0.05). Within the curved line model (12-14) and the straight line model (15-17), the mean errors between the conventional method and the digital method were not significant for most variables. Conclusions : The difference between curved lines and straight lines has an impact on the mean error of the conventional method. Both methods are reliable for straight and curved lines in partially dentate situations.

Background: This study compared the influence of crystallization on marginal gap adaptation by using computer-aided design and manufacturing (CAD-CAM) for producing monolithic zirconia-reinforced lithium silicate (ZLS) ceramic crowns., Methods: A total of 25 plastic teeth were scanned using a Primescan intra-oral scanner (IOS), and ZLS crowns were ground. For each unit (abutment and crown), the marginal gap was evaluated pre crystallization and post crystallization at four regions of interest through the use of a scanning electron microscope (SEM). To compare the marginal gap between the two groups, a Kolmogorov-Smirnov test performed on the study variables indicated a normal distribution ( p > 0.05) followed by paired samples T-tests (α = 0.0005)., Results: After crystallization, there were significantly higher circumferential marginal gaps (CMGs) for all four surfaces (distal ( p = 0.0005), mesial ( p = 0.0005), palatal ( p = 0.0005), and buccal ( p = 0.0005)). The total mean marginal gap (MMG) revealed a significantly higher result for the post-crystallization group (79.82 ± 7.86 μm) compared to the pre-crystallization group (24.25 ± 5.49 μm)., Conclusions: The post-crystallization group showed a significantly higher marginal gap compared to the pre-crystallization group in all parameters, but both groups were in the clinically accepted threshold (<120 microns). In terms of the marginal gap, it is arguable whether to carry out post-crystallization for CELTRA ® DUO crowns and achieve better mechanical properties but significantly increase the marginal gap.

The configuration of implant-supported prostheses is considered to influence the magnitude of stress concentrations, affecting their survival rate. The purpose of this study is to determine, through strain gauge measurements during load application, the dispersion and magnitude of strain concentrations in different implant-supported prosthesis designs. All designs matched those commonly used in posterior partially edentulous states. Three implants were inserted into an epoxy resin model (PLM-4B Vishay Measurements Group Inc., Raleigh, NC, USA), allowing for the delivery of three- and four-unit crowns in different cemented configurations. Loads were applied at vertical and oblique directions over the cast crowns in six different configurations representing various posterior partially edentulous restorations. The readings from the strain gauges adhered to the implant necks' presented data on implant strain. Prostheses including cantilevers showed the highest strain among the three-unit prostheses within the prosthetic complex, and three single units showed the least (8133 µs vs. 201 µs, respectively). Angulated load application also had a role in amplifying the strains recorded, resulting in total strains of between 3.5 and 20 times higher than during vertical loading in all configurations. It can be concluded that the configuration of implant-fixed partial prosthesis changes the loads engaging the restoration, the implant, and, probably, the supporting bone.

Background: The purpose of this in vitro study was to compare the inter-implant distance, inter-implant axis, and intra-implant axis of three implants in a straight line by using a laboratory scanner (LBS) versus an intra-oral scanner (IOS) with two different intra-oral scan bodies (ISBs)., Methods: A 3D model was printed with internal hex implant analogs of three implants in positions 15#, 16#, and 17#. Two standard intra-oral scan bodies (ISBs) were used: MIS ISB (two-piece titanium) and Zirkonzhan ISB (two-piece titanium). Both ISBs were scanned using 7 Series dental wings (LBS) and 30 times using Primescan (IOS). For each scan, a stereolithography (STL) file was created and a comparison between all the scans was performed through superimposition of the STL files by using 3D analysis software (PolyWorks ® 2020; InnovMetric, Québec, QC, Canada). A Kolmogorov-Smirnov test was performed followed by a Mann-Whitney test ( p < 0.05)., Results: The change in inter-implant distance for the MIS ISB was significantly lower compared to the ZZ ( p < 0.05). The change in intra-implant angle was significantly lower for the ZZ ISB compared to MIS ( p < 0.05). The changes in inter-implant angle between the mesial and middle and between the middle and distal were significantly lower for MIS compared to ZZ in contrast to mesial to distal, which was significantly higher ( p < 0.05)., Conclusions: Both ISBs showed differences in all the parameters between the LBS and the IOS. The geometry of the scan abutment had an impact on the inter-implant distance as the changes in the inter-implant distance were significantly lower for the MIS ISB. The changes in the intra-implant angle were significantly lower for the ZZ ISB. There is a need for further research examining the influence of geometry, material, and scan abutment parts on the trueness.

Even after a successful ventricular tachycardia ablation (VTA), some patients have recurrent ventricular tachycardia (VT) during their follow-up. We assessed the long-term predictors of recurrent VT after having a successful VTA. The patients who underwent a successful VTA (defined as the non-inducibility of any VT at the procedure's end) in 2014-2021 at our center in Israel were retrospectively analyzed. A total of 111 successful VTAs were evaluated. Out of them, 31 (27.9%) had a recurrent event of VT after the procedure during a median follow-up time of 264 days. The mean left ventricular ejection fraction (LVEF) was significantly lower among patients with recurrent VT events (28.9 ± 12.67 vs. 23.53 ± 12.224, p = 0.048). A high number of induced VTs (>two) during the procedure was found to be a significant predictor of VT recurrence (24.69% vs. 56.67%, 20 vs. 17, p = 0.002). In a multivariate analysis, a lower LVEF (HR, 0.964; p = 0.037) and a high number of induced VTs (HR, 2.15; p = 0.039) were independent predictors of arrhythmia recurrence. The inducibility of more than two VTs during a VTA procedure remains a predictor of VT recurrence even after a successful VT ablation. This group of patients remains at high risk for VT and should be followed up with and treated more vigorously.

Anti-PLA2R antibodies (Ab) are a diagnostic and prognostic biomarker in primary membranous nephropathy (PMN). We assessed the relationship between the levels of anti-PLA2R Ab at diagnosis and different variables related to disease activity and prognosis in a western population of PMN patients. Forty-one patients with positive anti-PLA2R Ab from three nephrology departments in Israel were enrolled. Clinical and laboratory data were collected at diagnosis and after one year of follow-up, including serum anti-PLA2R Ab levels (ELISA) and glomerular PLA2R deposits on biopsy. Univariable statistical analysis and permutation-based ANOVA and ANCOVA tests were performed. The median [(interquartile range (IQR)) age of the patients was 63 [50-71], with 28 (68%) males. At the time of diagnosis, 38 (93%) of the patients had nephrotic range proteinuria, and 19 (46%) had heavy proteinuria (≥8 gr/24 h). The median [IQR] level of anti-PLA2R at diagnosis was 78 [35-183] RU/mL. Anti-PLA2R levels at diagnosis were correlated with 24 h proteinuria, hypoalbuminemia and remission after one year ( p = 0.017, p = 0.003 and p = 0.034, respectively). The correlations for 24 h proteinuria and hypoalbuminemia remained significant after adjustment for immunosuppressive treatment ( p = 0.003 and p = 0.034, respectively). Higher levels of anti-PLA2R Ab at diagnosis in patients with active PMN from a western population are associated with higher proteinuria, lower serum albumin and remission one year after the diagnosis. This finding supports the prognostic value of anti-PLA2R Ab levels and their possible use in stratifying PMN patients.

Background: Fibromyalgia syndrome (FMS) is estimated to affect 2-4% of the general population. While FMS has some known environmental and genetic risk factors, the disorder has no clear etiology. A common coexisting disorder with FMS is small fiber neuropathy (SFN). High levels of serum immunoglobulin M (IgM) binding to trisulfated-heparin-disaccharide (TS-HDS) were recently found to be associated with SFN., Objectives: To evaluate potential differences in anti-TS-HDS antibody titers in women with FMS compared to healthy controls., Methods: In this cross-sectional study, we evaluated 51 female participants: 30 with a diagnosis of FMS and 21 healthy controls who had been recruited at the Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel. All of the participants were older than 18 years of age. Anti-TS-HDS IgM levels were measured in their sera using the enzyme immunoassay technique., Results: The mean anti-TS-HDS IgM levels were significantly lower in the FMS group, compared with the control group (7.7 ± 5 vs. 13.2 ± 8.6 U/ml, respectively; P = 0.013)., Conclusions: There is a possible association between FMS and anti-TS-HDS IgM. This association might be the missing link for the coexistence of SFN and FMS, but further study should be performed to assess this association and this auto-antibody characteristic.

Caries development in children is a prevalent childhood disease. Factors affecting chronic teeth lesions include nutrition, parental involvement, and executing proper dental health attitude. Professional dentists are perceived as role models for the oral health and hygiene of their families. The purposes of the research were 1. To compare caries rates in the children of pediatric dentists and children of general dentists. 2. To compare children's nutrition habits between pediatric dentists and general dentists. 3. To compare children's oral health and hygiene between pediatric dentists and general dentists. 4. To compare children's usage of fluoride-containing products between pediatric dentists and general dentists. A cross-sectional study was conducted by distributing self-reporting questionnaires to pediatric dentists and general dentists via the social media "snowball" platform. The following themes were surveyed: nutrition habits and oral hygiene of the children. The sample consisted of 176 participants. Children of pediatric dentists were found to have fewer cases of caries than children of general dentists ( p = 0.018). Nutrition habits did not differ between the two groups. In addition, pediatric dentists reported that their children use more fluoridated toothpaste in comparison with general dentists. Professional training of pediatric dentists contributed to shaping the oral hygiene attitude of their children.

A failed implant site is prone to reduced alveolar bone volume, both horizontally and vertically. The present study assessed the outcome of using cancellous bone block allografts for ridge reconstruction following the removal of failed implants associated with severe bone loss. Individuals presenting with failed implants and massive bone loss were included. Cancellous bone block allografts were used for reconstruction of the atrophic alveolar ridge. Radiographic evaluation at 6 months postgrafting revealed favorable bone healing, allowing implant placement. Bone biopsy samples were taken during implant placement. Twenty-four blocks and 58 implants were placed in 16 patients. Over a mean follow-up time of 40 ± 15 months, the mean bone gain was 5 ± 0.5 mm horizontally and 7 ± 0.5 mm vertically. Block and implant survival rates were 96% (1 block failed) and 95% (3 implants failed), respectively. Histomorphometrically, the mean percentage of newly formed bone was 40%, with 20% residual cancellous block allograft and 40% marrow and connective tissue. Cancellous bone block allograft is a viable treatment alternative for reconstructing the alveolar ridge to achieve a successful second reimplantation, even in the presence of initial severe bone loss.

Objectives: Ventricular tachycardia ablation (VTA) with hemodynamic compromise presents a challenge. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support allows the safe completion of the procedure. There are limited data regarding the safety of weaning off VA-ECMO at the end of the procedure. We report our experience with early VA-ECMO de-cannulation after VTA., Materials and Methods: All patients undergoing VA-ECMO-assisted VTA, between January 2013 and December 2020 at a large tertiary center were included. Clinical characteristics, history of arrhythmia, procedural details, and outcomes were collected. Patients weaned from VA-ECMO immediately at the end of the procedure were compared to those that were de-cannulated at a later time., Results: A total of 46 patients (93.5% male, age 62 ± 10 years) were ablated with VA-ECMO support. Most had ischemic cardiomyopathy (65%) and (70%) presented with VT storm. The clinical VT was induced in the majority of patients (76%). A total of 99 VTs were induced of which 76 (77%) were targeted and successfully ablated. Non-inducibility was achieved in 74% of cases and most patients (83%) were de-cannulated at the end of the procedure on the procedure table. Survival at 1 year was higher among early de-cannulated patients (86 vs. 38% [log-rank p -value < 0.001]). At 1-year follow-up, 91.3% of surviving patients were free of appropriate ICD shocks., Conclusion: De-cannulation from VA-ECMO may be done immediately at the conclusion of VTA in most cases. Failure to timely wean off VA-ECMO is a strong predictor of mortality., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Sabbag, Nissan, Beinart, Sternik, Kassif, Kogan, Ram and Nof.)

Background: Substantial effort is dedicated to finding the most favorable parameters that will ensure low aftercare demands among edentulous patients wearing mandibular implant supported overdentures (MISODs). The purpose of this retrospective cohort study was to compare prosthetic aftercare between MISOD patients with a simultaneous (group A) vs. a three-week settling in period (group B) prior to attachment incorporation., Methods: Forty-five patients enrolled in this study. Two implants per patient were placed using a two-stage implant insertion protocol. Second-stage surgery was performed after three months. All patients received ball attachments using the direct (chairside) incorporation method. Twenty-two patients received their dentures with simultaneous attachment activation and the rest-twenty-three patients-after a three-week settling in period. Patients' files were scanned for aftercare visits. Outcome parameters included sore spot relief, attachment incorporation, and denture repair. Additionally, gingival index measurements were compared. Confounding factors included age, gender, and implant dimensions., Results: The mean follow-up for the entire cohort was 84 ± 21 months, and the range 39-120 months. The mean number of visits for group A vs. B respectively: pressure sores relieve (3.63 ± 0.84 vs. 3.71 ± 0.61, p = 0.581), liner exchange due to loss of retention (2.09 ± 1.03 vs. 2.31 ± 1.04 p = 0.487), and gingival index (1.3 ± 0.3 vs. 1.03 ± 0.2, p = 0.653) exhibited no statistically significant differences between the tested groups. No statistically significant differences between the groups were also noted for the denture repair aftercare treatments ( p = 0.318) and the independent variables including age, gender, and implant length., Conclusions: Prosthetic aftercare in MISOD wearers is similar whether a simultaneous or a three-week settling in period for attachment incorporation is applied.

Background: Dietary habits, food intake and oral health are important factors for general health. The aim of these present study was to assess the association between implant-supported fixed oral rehabilitation and glycemia, by monitoring HbA1c values before and after implant-supported prostheses (ISP) delivery to diabetic individuals. Methods: Retrospective, cohort study based on dental records. All treatments were performed by experienced oral and maxillofacial surgeons and experienced prosthodontists. Inclusion criteria: ISP delivery, diagnosis of diabetes in the medical files, consecutive individuals. Variables included—primary outcome—differences (delta) in HbA1c values prior to implant placement and one year after ISP delivery, early implant failure (EIF). Confounding factors included age, gender, physical status, smoking, implant jaw location, implant length, implant width, total implant count per individual. Results: Statistically significant (p < 0.01) decrease in HbA1c from 7.10 ± 1.09% to 6.66 ± 1.02% following ISP delivery was recorded. The mean HbA1c delta was 0.44 ± 0.73%, where 39.0% of the patients had a significant improvement (delta decrease > 0.5%). Univariate and multivariate model using logistic regression at individual level showed that initial high HbA1c levels was the only factor positively predicting improvement (OR = 1.96, CI [1.22, 3.14], p < 0.01). Univariate model at implant level demonstrated that implants placed in the anterior maxilla also contributed to significant improvement in HbA1c values. Multivariate analysis at implant level was similar to individual level. Number of missing teeth did not affect the results significantly. Conclusion: ISP delivery to partially or completely edentulous diabetic individuals may improve HbA1c balance. The mechanism awaits future elucidation.

Background: Individuals with tooth agenesis often present a significant clinical challenge for dental practitioners. This retrospective study evaluated clinical and radiological long-term functional and esthetic outcomes following restoration using primary teeth to support fixed all-ceramic prosthesis in patients with teeth agenesis., Methods: Patients with teeth agenesis and at least one year follow-up were included. Examinations included panoramic X-ray, clinical examination and family history records. Only primary teeth without permanent teeth underneath were chosen. All ceramic fixed restorations were used. All data were collected from patient files. Outcome parameters included: restoration parameters (restoration survival, restoration fractures, restoration detachment, restoration replacement, and secondary caries), plaque index, and gingival index., Results: The study included 58 porcelain restorations inserted in 25 individuals; mean age 12 ± 2.1 years (range 10-19 years); mean number of missing teeth 12.3 ± 9 (range 6-12). Mean follow-up 48 ± 6 months (range 12-60 months). All restorations survived up to last follow-up, rendering a survival rate of 100%. Restorations outcome-porcelain chipping (9%), detachment (2%), no restoration replacement nor secondary caries, mean gingival index-0.7 ± 0.5 and mean plaque index-0.9 ± 0.3., Conclusions: In tooth agenesis, restoration using primary teeth to support fixed all-ceramic prosthesis is a viable treatment alternative.

Purpose: Evaluate the esthetic outcome of ridge augmentation using cancellous bone-block allografts, late implant placement, and immediate loading in the atrophic anterior maxilla, by PES (pink esthetic score) and WES (white esthetic score) indexes. Materials and Methods: Retrospective cohort study. Inclusion criteria were bone loss of at least 3 mm horizontally and 3 mm vertically according to preliminary CBCT; ridge augmentation using cancellous bone-block allografts; six months later the implant insertion and immediately loaded. PES-WES index was used for esthetic assessment of soft tissues surrounding the final implant-supported prosthesis (ISP). Results: All twenty-five successive individuals were included. The mean follow-up was 12.1 ± 56 months (range, 42−90 months). The mean PES index and WES index were 7 ± 1.74 (range: 5−10) and 8.4 ± 2.12 (range: 5−10), respectively. The mean total combination of PES index and WES index (PES/WES) was 15.3 ± 2.85 (range: 12−20). All ISPs had an overall score >12 (the defined threshold of clinical acceptability). Conclusions: Ridge augmentation in the atrophic anterior maxilla using cancellous bone-block allografts and immediate loading allows a stable esthetic result of the soft and hard tissues over the years (follow-up of 42−90 months).

Purpose: Treatment alternatives based on implant-supported prostheses (ISPs) may be almost impossible in cases with extremely atrophic mandibles. Vertical bone augmentation is then the only possibility to achieve an ISP., Materials and Methods: The consequences of vertical augmentation in extremely atrophic mandibles (≤ 10-mm bone height) of edentulous patients using allogeneic block grafts via a submental approach were assessed. The recorded parameters were sex, age, physical status, hospitalization duration, postoperative complications, implant characteristics (length, diameter), early and late implant failure (yes/no; primary outcome variable). Bone height was measured at three points using the pre-grafting and pre-implant placement CBCT imaging. The difference between the measurements was defined as bone gain (primary outcome variable)., Results: Sixteen patients (2 men, 14 women) were included. The preoperative bone height ranged from 4 to 10 mm. A mean of 5.3 ± 1 months was allowed for graft consolidation. The average bone height gain was 11.2 ± 3.1 mm. Two to six dental implants were placed in the grafted bone. Early implant failure occurred in 4 out of 73 (5.5%). Follow-up ranged from 12 to 92 (mean: 48 ± 30) months. All patients were followed for more than a year, and two additional late implant failures were recorded, rendering a 92% cumulative survival rate., Conclusion: Bone grafting using allogeneic bone blocks via a submental approach seems to be a promising solution for reconstruction of the extremely atrophic mandible.