346 results on '"Nista, Enrico"'
Search Results
2. Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment
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Sonnino, Rebecca, Ciccarelli, Gea, Moffa, Simona, Soldovieri, Laura, Di Giuseppe, Gianfranco, Brunetti, Michela, Cinti, Francesca, Di Piazza, Eleonora, Gasbarrini, Antonio, Nista, Enrico C., Pontecorvi, Alfredo, Giaccari, Andrea, and Mezza, Teresa more...
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- 2025
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Catalog
3. Human subjects with impaired beta-cell function and glucose tolerance have higher levels of intra-islet intact GLP-1
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Mezza, Teresa, Wewer Albrechtsen, Nicolai J., Di Giuseppe, Gianfranco, Ferraro, Pietro Manuel, Soldovieri, Laura, Ciccarelli, Gea, Brunetti, Michela, Quero, Giuseppe, Alfieri, Sergio, Nista, Enrico Celestino, Gasbarrini, Antonio, Tondolo, Vincenzo, Mari, Andrea, Pontecorvi, Alfredo, Giaccari, Andrea, and Holst, Jens J. more...
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- 2025
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4. A single-center prospective analysis of the impact of glucose metabolism on pancreatic fistula onset after pancreaticoduodenectomy for periampullary tumors
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Quero, Giuseppe, Laterza, Vito, Di Giuseppe, Gianfranco, Lucinato, Chiara, Massimiani, Giuseppe, Nista, Enrico Celestino, Sionne, Francesco, Biffoni, Beatrice, Brunetti, Michela, Rosa, Fausto, De Sio, Davide, Ciccarelli, Gea, Fiorillo, Claudio, Menghi, Roberta, Langellotti, Lodovica, Soldovieri, Laura, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Alfieri, Sergio, Tondolo, Vincenzo, and Mezza, Teresa more...
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- 2024
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5. In humans increase in intrapancreatic adipose tissue predicts beta-cell dedifferentiation score before diabetes onset: A pilot study
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Cinti, Francesca, Mezza, Teresa, Severi, Ilenia, Moffa, Simona, Giuseppe, Gianfranco Di, Capece, Umberto, Ciccarelli, Gea, Soldovieri, Laura, Brunetti, Michela, Morciano, Cassandra, Gugliandolo, Shawn, Senzacqua, Martina, Avolio, Adriana, Quero, Giuseppe, Tondolo, Vincenzo, Nista, Enrico Celestino, Moroni, Rossana, Cinti, Saverio, Alfieri, Sergio, Gasbarrini, Antonio, Pontecorvi, Alfredo, and Giaccari, Andrea more...
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- 2025
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6. Beta-cell function and glucose metabolism in patients with chronic pancreatitis
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Ciccarelli, Gea, Di Giuseppe, Gianfranco, Soldovieri, Laura, Quero, Giuseppe, Nista, Enrico Celestino, Brunetti, Michela, Cinti, Francesca, Moffa, Simona, Capece, Umberto, Tondolo, Vincenzo, Mari, Andrea, Gasbarrini, Antonio, Pontecorvi, Alfredo, Alfieri, Sergio, Giaccari, Andrea, and Mezza, Teresa more...
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- 2024
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7. The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes
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Carciero, Lorenzo, Di Giuseppe, Gianfranco, Di Piazza, Eleonora, Parand, Erfan, Soldovieri, Laura, Ciccarelli, Gea, Brunetti, Michela, Gasbarrini, Antonio, Nista, Enrico C., Pani, Giovambattista, Pontecorvi, Alfredo, Giaccari, Andrea, and Mezza, Teresa more...
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- 2024
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8. Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes
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Di Giuseppe, Gianfranco, Soldovieri, Laura, Ciccarelli, Gea, Ferraro, Pietro Manuel, Quero, Giuseppe, Cinti, Francesca, Capece, Umberto, Moffa, Simona, Nista, Enrico Celestino, Gasbarrini, Antonio, Mari, Andrea, Alfieri, Sergio, Tondolo, Vincenzo, Pontecorvi, Alfredo, Holst, Jens Juul, Giaccari, Andrea, and Mezza, Teresa more...
- Abstract
To the Editor: The incretin effect (IE) is a key factor regulating [beta] cell functional response and affecting the dynamics of insulin secretion (1). The main actors in the IE [...]
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- 2024
9. An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes
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Soldovieri, Laura, Di Giuseppe, Gianfranco, Ciccarelli, Gea, Quero, Giuseppe, Cinti, Francesca, Brunetti, Michela, Nista, Enrico C., Gasbarrini, Antonio, Alfieri, Sergio, Pontecorvi, Alfredo, Giaccari, Andrea, and Mezza, Teresa more...
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- 2023
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10. First-phase insulin secretion: can its evaluation direct therapeutic approaches?
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Di Giuseppe, Gianfranco, Ciccarelli, Gea, Soldovieri, Laura, Capece, Umberto, Cefalo, Chiara M.A., Moffa, Simona, Nista, Enrico C., Brunetti, Michela, Cinti, Francesca, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, and Mezza, Teresa more...
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- 2023
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11. The Role of the Gastrointestinal Microbiota in Parkinson's Disease.
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Gabrielli, Maurizio, Zileri Dal Verme, Lorenzo, Zocco, Maria Assunta, Nista, Enrico Celestino, Ojetti, Veronica, and Gasbarrini, Antonio
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FECAL microbiota transplantation ,PARKINSON'S disease ,HELICOBACTER pylori infections ,GUT microbiome ,INTESTINAL barrier function - Abstract
Background/Objectives: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons leading to debilitating motor and non-motor symptoms. Beyond its well-known neurological features, emerging evidence underscores the pivotal role of the gut–brain axis and gastrointestinal microbiota in PD pathogenesis. Dysbiosis has been strongly linked to PD and is associated with increased intestinal permeability, chronic inflammation, and the production of neurotoxic metabolites that may exacerbate neuronal damage. Methods: This review delves into the complex interplay between PD and dysbiosis, shedding light on two peculiar subsets of dysbiosis, Helicobacter pylori infection and small-intestinal bacterial overgrowth. These conditions may not only contribute to PD progression but also influence therapeutic responses such as L-dopa efficacy. Conclusions: The potential to modulate gut microbiota through probiotics, prebiotics, and synbiotics; fecal microbiota transplantation; and antibiotics represents a promising frontier for innovative PD treatments. Despite this potential, the current evidence is limited by small sample sizes and methodological variability across studies. Rigorous, large-scale, randomized placebo-controlled trials with standardized treatments in terms of composition, dosage, and duration are urgently needed to validate these findings and pave the way for microbiota-based therapeutic strategies in PD management. [ABSTRACT FROM AUTHOR] more...
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- 2025
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12. The Past, Present, and Future of Biomarkers for the Early Diagnosis of Pancreatic Cancer.
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Vitale, Federica, Zileri Dal Verme, Lorenzo, Paratore, Mattia, Negri, Marcantonio, Nista, Enrico Celestino, Ainora, Maria Elena, Esposto, Giorgio, Mignini, Irene, Borriello, Raffaele, Galasso, Linda, Alfieri, Sergio, Gasbarrini, Antonio, Zocco, Maria Assunta, and Nicoletti, Alberto more...
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PANCREATIC secretions ,PANCREATIC cancer ,BODY fluids ,CANCER diagnosis ,INDIVIDUALIZED medicine - Abstract
Pancreatic cancer is one of the most aggressive cancers with a very poor 5-year survival rate and reduced therapeutic options when diagnosed in an advanced stage. The dismal prognosis of pancreatic cancer has guided significant efforts to discover novel biomarkers in order to anticipate diagnosis, increasing the population of patients who can benefit from curative surgical treatment. CA 19-9 is the reference biomarker that supports the diagnosis and guides the response to treatments. However, it has significant limitations, a low specificity, and is inefficient as a screening tool. Several potential biomarkers have been discovered in the serum, urine, feces, and pancreatic juice of patients. However, most of this evidence needs further validation in larger cohorts. The advent of advanced omics sciences and liquid biopsy techniques has further enhanced this field of research. The aim of this review is to analyze the historical evolution of the research on novel biomarkers for the early diagnosis of pancreatic cancer, focusing on the current evidence for the most promising biomarkers from different body fluids and the novel trends in research, such as omics sciences and liquid biopsy, in order to favor the application of modern personalized medicine. [ABSTRACT FROM AUTHOR] more...
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- 2024
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13. Effect of influenza vaccine on COVID-19 mortality: a retrospective study
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Candelli, Marcello, Pignataro, Giulia, Torelli, Enrico, Gullì, Antonio, Nista, Enrico Celestino, Petrucci, Martina, Saviano, Angela, Marchesini, Debora, Covino, Marcello, Ojetti, Veronica, Antonelli, Massimo, Gasbarrini, Antonio, and Franceschi, Francesco more...
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- 2021
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14. Reduced incretin effect precedes diabetes development following duodenopancreatectomy in subjects without diabetes
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Di Giuseppe, Gianfranco, primary, Soldovieri, Laura, additional, Ciccarelli, Gea, additional, Ferraro, Pietro Manuel, additional, Quero, Giuseppe, additional, Cinti, Francesca, additional, Capece, Umberto, additional, Moffa, Simona, additional, Nista, Enrico Celestino, additional, Gasbarrini, Antonio, additional, Mari, Andrea, additional, Alfieri, Sergio, additional, Tondolo, Vincenzo, additional, Pontecorvi, Alfredo, additional, Holst, Jens Juul, additional, Giaccari, Andrea, additional, and Mezza, Teresa, additional more...
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- 2024
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15. Global trends in opioid use for pain management in acute pancreatitis: A multicentre prospective observational study
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Knoph, Cecilie Siggaard, Lucocq, James, Kamarajah, Sivesh Kathir, Olesen, Søren Schou, Jones, Michael, Samanta, Jayanta, Talukdar, Rupjyoti, Capurso, Gabriele, de‐Madaria, Enrique, Yadav, Dhiraj, Siriwardena, Ajith K., Windsor, John, Drewes, Asbjørn Mohr, Nayar, Manu, Cark, Neil, Pius, Riinu, Houghton, Eduardo, Gimenéz, Mariano, Uribe, Karla, Rodriguez, Florencia, Gundara, Justin, Mackay, Thomas, Phan, Huynh, Lewin, Joel, McElhatton, Claire, Siriwardhane, Mehan, Hodgson, Russell, Malik, Hassan, Ward, Ryan, Young, Kerilee, Bappayya, Shaneel, Loveday, Benjamin, Samra, Jaswinder, Gall, Tamara, Mittal, Anubhav, Chan, Ting Ting, Lo, Vincent Wing‐ho, Liang, Hui, Wang, Cong, Huang, Wei, Jin, Tao, Wu, Yongzi, Xia, Qing, Georgio, Nikolaou, Koronakis, Nikolaos, Davidsen, Line, Hamed, Emad, Mohamed, Salem, Demetrashvili, Zaza, Tvaladze, Ana, Kachakhidze, Irakli, Zurabashvili, Tea, Ioannidis, Orestis, Kapiris, Stylianos, Mavrodimitraki, Eleni, Sotiropoulou, Maria, Machairas, Nikolaos, Schizas, Dimitrios, Syllaios, Athanasios, Vailas, Michail, Chlorakis, Georgios, Kalaitzakis, Evangelos, Tsafaridou, Maria, Mulita, Francesk, Verras, Georgios‐Ioannis, Gupta, Amit, Rajput, Deepak, Sharma, Oshin, Goud, Rajesh, Unnisa, Misbah, Bains, Lovenish, Singh, Nishu, Dhar, Jahnvi, Abdelmoeti, Mahmoud, Súilleabháin, Criostóir Ó, O'Connell, Robert, Calabro, Marcello, La Terra, Antonio, Muretore, Andrea, Contul, Riccardo Brachet, Diotallevi, Margherita, Mascaro, Annamaria, Millo, Paolo, Biondo, Santino Antonio, Mazzeo, Carmelo, Cucinotta, Eugenio, Fleres, Francesco, Marinak, AOUG, Brocco, Veronica, Ceresoli, Marco, Rennis, Maria, Centonze, Danilo, Distefano, Coatanza, Veroux, Massimiliano, Zerbo, Domenico, Bogoni, Selene, Biloslavo, Alan, Bianchi, Velentina, Candelli, Marcello, Franceschi, Francesco, Gasbarrini, Antonio, Nista, Enrico, Sganga, Gabriele, Tropeano, Giuseppe, Policlinico, Fondazione, Altieri, Caterina, Dinuzzi, Vincenza, Marconi, Matteo, Rivolta, Umberto, Dameno, Vitale Roberto, Papa, Mario V., Balla, Andrea, Lepiane, Pasquale, Saraceno, Federica, Aiolfi, Alberto, Bona, Davide, Sozzi, Andrea, Cianci, Pasquale, Varesano, Marco, Conversano, Ivana, Abete, Roberta, D'Avino, Raffaele, Marra, Ester, Marte, Gianpaolo, Tammaro, Pasquale, Gobatti, Davide, Marmaggi, Serena, Palmieri, Francesco, Sampietro, Roberto, Manca, Roberto, Pilla, Federica, Piras, Enrico, Pignata, Giusto, Canfora, Ilaria, Andreuccetti, Jacopo, D'Alessio, Rossella, Armellin, Claudia, Grossi, Ugo, Massani, Marco, Pontin, Alessandro, Stecca, Tommaso, Pilia, Tiaizna, Pisanu, Adolfo, Podda, Mauro, Giuffrida, Mario, Perrone, Gennaro, Guadagni, Simone, Morelli, Luca, Frontali, Alice, Basurto, Francesca, D'Ugo, Stefano, Manoochehri, Farshad, Spampinato, Marcello, Apadula, Laura, Preatoni, Paoletta, Sartarelli, Lodovico, Al‐Jaiuossi, Osama, Ernisova, Mairam, Sopuev, Andrey, Sua, Bruce, Farfus, Anthony, Teo, Keith, Smith, Brittany, Ratnayake, Bathiya, Buchanan, Jayvee, Clark, Elinor, Connor, Saxon, Hore, Todd, Attari, Salman, Kadir, Bushra, Memon, Sadik, Abbas, Zaigham, Quadeer, Muhammad Ali, Altaf, Abeer, Ameet, Pooja, Devi, Jalpa, Seerani, Nandlal, Afzal, Ameer, Akbar, Ali, Asghar, Mohammad Sohail, Sa, Tiago, Barreira, Ana Lucia, Carvalho, Numo, Cismasiu, Brigitta, Henriques, Susana, Luiz, Francisco Vara, Draghici, Andreea, Grigorean, Valentin, Porojan, Vlad, Stoian, Alexandru‐Rares, Teaca, Lucia, Arbutina, Dragana, Cuk, Vladica, Kovacevic, Bojan, Mandic, Luka, Bonney, Glenn, Gao, Yujia, Pang, Ning Qi, Bellil, Abdalla, Devar, John, Khan, Zafar, Khumalo, Vusi, Smith, Martin, Estevez‐Fernandez, Sergio, Mosquera, Beatriz Romero, Rodriguez, Sergio, Garcia‐Rayado, Guillermo, Piñerua‐Gonsalvez, Jean Felix, Ruiz Rebollo, M Lourdes, Olmos, Jose M., Tejedor‐Tejada, Javier, Diez‐Alonso, Manuel, Matias‐Garcia, Belen, Moreno, Fernando Mendoza, Vera‐Mansilla, Cristina, Roses, Helena Salvador, Gómez, Diego Vázquez, Oballe, Juan Rodriguez, Jayarajah, Umesh, Nandasena, Malith, Pathirana, Aloka, Galal‐Eldin, Sami, Hajibandeh, Shahab, Hamid, Hytham, Colak, Elif, Sydorchuk, Larysa, Knut, Ruslan, Voronyuk, Ksenia, Chooklin, Serge, Baryskyi, Vitalii, Sydorchuk, Ruslan, Mukherjee, Samrat, Patel, Maitreyi, Akhtar, Amina, Asarbakhsh, Miriam, Nolan, Frances, Schuijtvlot, Nicholaas, Prem, Sandhya, Thrikandiyur, Anuradha, Morris, Millicent, Mroczek, Thomas, Sgourakis, George, Sultana, Asma, Varley, Rebecca, Groot‐Wassink, Thomas, Labinoti, Roland, Packham, Brett, Seebah, Keving, Allen, Sophie, Mokhtassi, Shiva, Belgaumkar, Ajay, De'Ath, Henry, Cook, Amy, Delaney, Christopher, Johnson, Roisin, Azibaodinami, Becky Olali, Sartini, Ashley, Stanfield, Mea, Tomasi, Ivan, Kanakala, Venkat, Mbarushimana, Simon, McKeever, Mark, Batilli, Mamata, Bhatta, Gakul, Rai, Subash, Bond‐smith, Giles, Elserafy, Amr, Shams, Mohamed, Al Saoudi, Tareq, Bhardwaj, Neil, Hussain, Wajith, Lancellotti, Francesco, Montagnini, Greta, Cairns, George, Hollyman, Marianne, Rakin, Asef, Shahid, Mishal, Barbour, Fraser, Hawkyard, Jake, McTeer, Matthew, Pandanaboyana, Sanjay, Taylor, Ellie, Kuzman, Matta, Dyer, Sarah, Hopkins, James, Pournaras, Dimitri, Sudlow, Alexis, Kumar, SK, Aujayeb, Avinash, Leo, Alex, Senra, Fatima Lorenzana, Watfah, Josef, Barrie, Jenifer, Brown, Chris, Gomez, Dhanny, Aroori, Somaiah, Ciprani, Debora, Karmarkar, Rahi, Almomani, Eyas, Roberts, Keith, Fale, Madeleine, Gupta, Ajay, Marsden, Max, Seet, Chris, Soni, Lakshya, Hamdan, Mohammed, Sadera, Rohan, Sud, Vikas, Chinnah, Edith, Di Mauro, Davide, Manzelli, Antonio, Orabi, Amira, Presa, Roberto, Reece‐Smith, Alex, Wajed, Shahjehan, Fingret, Jacob, Shah, Nehal, Jatania, Jignesh, Krishna, Arun, Berry, David, Kitsikosta, Loukiani, Helliwell, Jack, Huntley, Benjamin, Pine, James, Yau, Jih‐Dar, Lee, Shiela, Mahawar, Kamal, Shetty, Neehar, Britton, Emily, Shaw, Alice, Laarhoven, Stijn, Gahunia, Sukhpreet, Ortega, Miguel Gargia, Lee, Adam, Ng, Cho Ee, El Kafsi, Jihene, Mason, John, Vithlani, Gauri, Benhmida, Rami, Gunell, James, Parmar, Chetan, Dorkeh, Da‐Costa, Elnagar, Mohamed, Lee, Jih Ian, Nessa, Ashrafun, Yeap, Zhu Hui, Hemadasa, Niroshini, Javed, Saria, Sami, Sharuk, Damaskos, Dimitrios, Healey, Andrew, Soupashi, Maria, Triantafyllou, Tania, Coats, Maria, Douglass, Benjamin, Hendry, Brid, Hussain, Yasmin, Javid, Zhara, Mantyla, Mia, Rajkumar, Khaman, Chin, Carven, Hajibandeh, Shahab, Kumar, Nagappan, Gerogiannis, Ioannis, Kapsampelis, Panagiotis, Gerge, Farid, Anderson, Gulsum, Dinh, Vu, Phillips, Anna, Yadav, Dhiraj, and Pandanaboyana, Sanjay more...
- Abstract
Since there is no current international consensus on the optimal approach for pain management in acute pancreatitis (AP), analgesic practices may vary across different healthcare settings. This study explored global disparities in analgesic use, in particular opioids, during admission and at discharge in hospitalised AP patients. This was a post hoc analysis of the prospective PAINAP database, which included all admissions for AP between April and June 2022 with a 1‐month follow‐up. Demographic details, analgesic use, and clinical outcomes were recorded during admission and at discharge. Odds ratios (ORs) for opioid use during admission and at discharge were identified using multivariable regression analyses. Amongst the 1864 patients (52% males, median age 56 (interquartile range, 41–71)) across three different continents, simple analgesics were predominantly used as the primary analgesic (70%). Opioid use during admission was lowest in European centres (67%). Admission in Asian (OR, 2.53 (95% confidence interval (CI), 1.59–4.04), p< 0.001), and Australian (OR, 5.81 (95% CI, 3.19–10.56), p< 0.001) centres was associated with opioid administration during admission compared with European centres. Increased pain severity, longer pre‐admission pain duration, organ failure, and longer length of admission increased opioid use during admission. At discharge, Asian (OR, 2.01 (95% CI, 1.40–2.88), p< 0.001) and Australian (OR, 1.91 (95% CI, 1.28–2.85), p= 0.002) centres were associated with opioid prescription compared with European centres. Increased pain severity, longer pre‐admission pain duration, acute necrotic collections, and walled‐off necrosis also increased the likelihood of opioid prescription at discharge. There are substantial intercontinental differences in opioid use for AP pain. Accordingly, there is a need for international guidelines on pain management in AP. more...
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- 2024
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16. Neuropancreatology: The Nervous System and Pain Management in Pancreatic Diseases
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Nicoletti, Alberto, primary, Vitale, Federica, additional, Paratore, Mattia, additional, Quero, Giuseppe, additional, Negri, Marcantonio, additional, Nista, Enrico Celestino, additional, Alfieri, Sergio, additional, Gasbarrini, Antonio, additional, and Zileri Dal Verme, Lorenzo, additional more...
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- 2024
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17. Advancing Diabetes Research: A Novel Islet Isolation Method from Living Donors.
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Di Piazza, Eleonora, Todi, Laura, Di Giuseppe, Gianfranco, Soldovieri, Laura, Ciccarelli, Gea, Brunetti, Michela, Quero, Giuseppe, Alfieri, Sergio, Tondolo, Vincenzo, Pontecorvi, Alfredo, Gasbarrini, Antonio, Nista, Enrico Celestino, Giaccari, Andrea, Pani, Giovambattista, and Mezza, Teresa more...
- Subjects
INSULIN ,ISLANDS ,TYPE 2 diabetes ,ISLANDS of Langerhans ,DIABETES - Abstract
Pancreatic islet isolation is critical for type 2 diabetes research. Although -omics approaches have shed light on islet molecular profiles, inconsistencies persist; on the other hand, functional studies are essential, but they require reliable and standardized isolation methods. Here, we propose a simplified protocol applied to very small-sized samples collected from partially pancreatectomized living donors. Islet isolation was performed by digesting tissue specimens collected during surgery within a collagenase P solution, followed by a Lympholyte density gradient separation; finally, functional assays and staining with dithizone were carried out. Isolated pancreatic islets exhibited functional responses to glucose and arginine stimulation mirroring donors' metabolic profiles, with insulin secretion significantly decreasing in diabetic islets compared to non-diabetic islets; conversely, proinsulin secretion showed an increasing trend from non-diabetic to diabetic islets. This novel islet isolation method from living patients undergoing partial pancreatectomy offers a valuable opportunity for targeted study of islet physiology, with the primary advantage of being time-effective and successfully preserving islet viability and functionality. It enables the generation of islet preparations that closely reflect donors' clinical profiles, simplifying the isolation process and eliminating the need for a Ricordi chamber. Thus, this method holds promises for advancing our understanding of diabetes and for new personalized pharmacological approaches. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
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18. IPMN progression over time: modifiable risk and protective factors
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Schepis, Tommaso, primary, Pellegrino, Antonio Agostino, additional, Giuli, Lucia, additional, Candelli, Marcello, additional, De Lucia, Sara Sofia, additional, Mezza, Teresa, additional, Gasbarrini, Antonio, additional, and Nista, Enrico Celestino, additional more...
- Published
- 2023
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19. Pancreatic steatosis: metabolic implications and correlation with ultrasound findings
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De Lucia, Sara Sofia, primary, Nista, Enrico Celestino, additional, Zocco, Maria Assunta, additional, Ainora, Maria Elena, additional, Soldovieri, Laura, additional, Schepis, Tommaso, additional, Pellegrino, Antonio, additional, Del Gaudio, Angelo, additional, Gasbarrini, Antonio, additional, and Mezza, Teresa, additional more...
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- 2023
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20. Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review
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Del Gaudio, Angelo, primary, Covello, Carlo, additional, Di Vincenzo, Federica, additional, De Lucia, Sara Sofia, additional, Mezza, Teresa, additional, Nicoletti, Alberto, additional, Siciliano, Valentina, additional, Candelli, Marcello, additional, Gasbarrini, Antonio, additional, and Nista, Enrico Celestino, additional more...
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- 2023
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21. Physical Activity and Type 2 Diabetes: In Search of a Personalized Approach to Improving β-Cell Function
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Di Murro, Emanuela, primary, Di Giuseppe, Gianfranco, additional, Soldovieri, Laura, additional, Moffa, Simona, additional, Improta, Ilaria, additional, Capece, Umberto, additional, Nista, Enrico Celestino, additional, Cinti, Francesca, additional, Ciccarelli, Gea, additional, Brunetti, Michela, additional, Gasbarrini, Antonio, additional, Pontecorvi, Alfredo, additional, Giaccari, Andrea, additional, and Mezza, Teresa, additional more...
- Published
- 2023
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22. State-of-the-Art and Upcoming Innovations in Pancreatic Cancer Care: A Step Forward to Precision Medicine
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Schepis, Tommaso, primary, De Lucia, Sara Sofia, additional, Pellegrino, Antonio, additional, del Gaudio, Angelo, additional, Maresca, Rossella, additional, Coppola, Gaetano, additional, Chiappetta, Michele Francesco, additional, Gasbarrini, Antonio, additional, Franceschi, Francesco, additional, Candelli, Marcello, additional, and Nista, Enrico Celestino, additional more...
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- 2023
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23. Antibiotic Utilization in Acute Pancreatitis: A Narrative Review
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Severino, Andrea, primary, Varca, Simone, additional, Airola, Carlo, additional, Mezza, Teresa, additional, Gasbarrini, Antonio, additional, Franceschi, Francesco, additional, Candelli, Marcello, additional, and Nista, Enrico Celestino, additional more...
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- 2023
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24. Risk factors for the occurrence of ampullary tumors: A case-control study
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Zaccari, Piera, Archibugi, Livia, Belfiori, Giulio, Nista, Enrico Celestino, Dell'Anna, Giuseppe, Crippa, Stefano, Schepis, Tommaso, Tacelli, Matteo, Aleotti, Francesca, Petrone, Maria Chiara, Mariani, Alberto, Costamagna, Guido, Gasbarrini, Antonio, Larghi, Alberto Leonardo, Falconi, Massimo, Arcidiacono, Paolo Giorgio, Capurso, Gabriele, Nista, Enrico, Costamagna, Guido (ORCID:0000-0002-8100-2731), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Larghi, Alberto, Zaccari, Piera, Archibugi, Livia, Belfiori, Giulio, Nista, Enrico Celestino, Dell'Anna, Giuseppe, Crippa, Stefano, Schepis, Tommaso, Tacelli, Matteo, Aleotti, Francesca, Petrone, Maria Chiara, Mariani, Alberto, Costamagna, Guido, Gasbarrini, Antonio, Larghi, Alberto Leonardo, Falconi, Massimo, Arcidiacono, Paolo Giorgio, Capurso, Gabriele, Nista, Enrico, Costamagna, Guido (ORCID:0000-0002-8100-2731), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Larghi, Alberto more...
- Abstract
Background: The incidence of ampullary tumors is increasing but data on association with an increased exposure to certain risk factors are scanty. Objective: To investigate risk and protective factors associated with the occurrence of ampullary tumors and whether these factors differ between ampullary tumors of the intestinal and pancreatobiliary subtypes or between adenomas and carcinomas. Methods: The association between a large set of exposome features and ampullary tumors occurrence was investigated in a bi-centric case-control study after ethic committee approval and power calculation. Results: In 223 histologically confirmed patients and 446 controls, previous cholecystectomy (odd ratio [OR] = 2.07; 95% confidence interval [CI] = 1.34-3.20) and proton pump inhibitors use (OR = 1.66; 95% CI = 1.16-2.37) were associated with increased risk of ampullary tumors, aspirin use (OR = 0.57; 95% CI = 0.36-0.90) and light alcohol intake (OR = 0.54; 95% CI = 0.38-0.76) with reduced risk. A previous cholecystectomy was also associated with tumors of intestinal subtype and with both adenomas and carcinomas, and proton pump inhibitors use with adenomas only. Smoking, body mass index, family history of cancers, previous ulcer, diabetes and use of statins, insulin and metformin were not significant factors. Conclusion: This is the first case-control study specifically highlighting factors associated with the occurrence of ampullary tumors. We report factors that are novel and plausible, in keeping with mechanisms described for other gastrointestinal tumors and with potential clinical relevance. more...
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- 2022
25. State-of-the-Art and Upcoming Innovations in Pancreatic Cancer Care: A Step Forward to Precision Medicine
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Schepis, Tommaso, De Lucia, Sara Sofia, Pellegrino, Antonio Agostino, Del Gaudio, Angelo, Maresca, Rossella, Coppola, Gaetano, Chiappetta, Michele Francesco, Gasbarrini, Antonio, Franceschi, Francesco, Candelli, Marcello, Nista, Enrico Celestino, Pellegrino, Antonio, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Candelli, Marcello (ORCID:0000-0001-8443-7880), Schepis, Tommaso, De Lucia, Sara Sofia, Pellegrino, Antonio Agostino, Del Gaudio, Angelo, Maresca, Rossella, Coppola, Gaetano, Chiappetta, Michele Francesco, Gasbarrini, Antonio, Franceschi, Francesco, Candelli, Marcello, Nista, Enrico Celestino, Pellegrino, Antonio, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Franceschi, Francesco (ORCID:0000-0001-6266-445X), and Candelli, Marcello (ORCID:0000-0001-8443-7880) more...
- Abstract
Simple Summary Pancreatic cancer remains a major therapeutic challenge despite medical advances. The incidence of pancreatic cancer is increasing, and this disease is associated with a high mortality and morbidity rate. The poor prognosis of pancreatic cancer can be attributed to several factors, including the difficulty of early diagnosis due to the lack of specific symptoms and biomarkers in the early stages, the aggressiveness of the disease, and its resistance to systemic therapies. However, recent advances in the field have led to promising new therapeutic strategies, and endoscopists have assumed a key role in the multidisciplinary management of this disease. The aim of this article is to provide a comprehensive literature review focused on examining existing treatments for various stages of pancreatic cancer, with an emphasis on new and innovative therapeutic approaches. Pancreatic cancer remains a social and medical burden despite the tremendous advances that medicine has made in the last two decades. The incidence of pancreatic cancer is increasing, and it continues to be associated with high mortality and morbidity rates. The difficulty of early diagnosis (the lack of specific symptoms and biomarkers at early stages), the aggressiveness of the disease, and its resistance to systemic therapies are the main factors for the poor prognosis of pancreatic cancer. The only curative treatment for pancreatic cancer is surgery, but the vast majority of patients with pancreatic cancer have advanced disease at the time of diagnosis. Pancreatic surgery is among the most challenging surgical procedures, but recent improvements in surgical techniques, careful patient selection, and the availability of minimally invasive techniques (e.g., robotic surgery) have dramatically reduced the morbidity and mortality associated with pancreatic surgery. Patients who are not candidates for surgery may benefit from locoregional and systemic therapy. In some cases (e.g., patients for more...
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- 2023
26. This title is unavailable for guests, please login to see more information.
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Di Murro, Emanuela, Di Giuseppe, Gianfranco, Soldovieri, Laura, Moffa, Simona, Improta, I., Capece, Umberto, Nista, Enrico Celestino, Cinti, Francesca, Ciccarelli, Gea, Brunetti, Michela, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa, Di Murro E., Di Giuseppe G., Soldovieri L., Moffa S., Capece U., Nista E. C., Cinti F. (ORCID:0000-0001-5170-7055), Ciccarelli G., Brunetti M., Gasbarrini A. (ORCID:0000-0002-7278-4823), Pontecorvi A. (ORCID:0000-0003-0570-6865), Giaccari A. (ORCID:0000-0002-7462-7792), Mezza T. (ORCID:0000-0001-5407-9576), Di Murro, Emanuela, Di Giuseppe, Gianfranco, Soldovieri, Laura, Moffa, Simona, Improta, I., Capece, Umberto, Nista, Enrico Celestino, Cinti, Francesca, Ciccarelli, Gea, Brunetti, Michela, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa, Di Murro E., Di Giuseppe G., Soldovieri L., Moffa S., Capece U., Nista E. C., Cinti F. (ORCID:0000-0001-5170-7055), Ciccarelli G., Brunetti M., Gasbarrini A. (ORCID:0000-0002-7278-4823), Pontecorvi A. (ORCID:0000-0003-0570-6865), Giaccari A. (ORCID:0000-0002-7462-7792), and Mezza T. (ORCID:0000-0001-5407-9576) more...
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- 2023
27. Pancreatic Cancer Resistance to Treatment: The Role of Microbiota
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Nista, Enrico Celestino, Del Gaudio, Angelo, Del Vecchio, Livio Enrico, Mezza, Teresa, Pignataro, Giulia, Piccioni, Andrea, Gasbarrini, Antonio, Franceschi, Francesco, Candelli, Marcello, Mezza, Teresa (ORCID:0000-0001-5407-9576), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Candelli, Marcello (ORCID:0000-0001-8443-7880), Nista, Enrico Celestino, Del Gaudio, Angelo, Del Vecchio, Livio Enrico, Mezza, Teresa, Pignataro, Giulia, Piccioni, Andrea, Gasbarrini, Antonio, Franceschi, Francesco, Candelli, Marcello, Mezza, Teresa (ORCID:0000-0001-5407-9576), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Franceschi, Francesco (ORCID:0000-0001-6266-445X), and Candelli, Marcello (ORCID:0000-0001-8443-7880) more...
- Abstract
Pancreatic cancer (PC) is an aggressive malignancy and the fourth leading cause of cancer death in the United States and Europe. It is estimated that PC will be the second leading cause of cancer death by 2030. In addition to late diagnosis, treatment resistance is a major cause of shortened survival in pancreatic cancer. In this context, there is growing evidence that microbes play a regulatory role, particularly in therapy resistance and in creating a microenvironment in the tumor, that favors cancer progression. The presence of certain bacteria belonging to the gamma-proteobacteria or mycoplasmas appears to be associated with both pharmacokinetic and pharmacodynamic changes. Recent evidence suggests that the microbiota may also play a role in resistance mechanisms to immunotherapy and radiotherapy. However, the interactions between microbiota and therapy are bilateral and modulate therapy tolerance. Future perspectives are increasingly focused on elucidating the role of the microbiota in tumorigenesis and processes of therapy resistance, and a better understanding of these mechanisms may provide important opportunities to improve survival in these patients. more...
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- 2023
28. Nutrition in Acute Pancreatitis: From the Old Paradigm to the New Evidence
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De Lucia, Sara Sofia, Candelli, Marcello, Polito, Giorgia, Maresca, Rossella, Mezza, Teresa, Schepis, Tommaso, Pellegrino, Antonio Agostino, Zileri Dal Verme, Lorenzo, Nicoletti, Alberto, Franceschi, Francesco, Gasbarrini, Antonio, Nista, Enrico Celestino, Candelli, Marcello (ORCID:0000-0001-8443-7880), Mezza, Teresa (ORCID:0000-0001-5407-9576), Pellegrino, Antonio, Franceschi, Francesco (ORCID:0000-0001-6266-445X), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), De Lucia, Sara Sofia, Candelli, Marcello, Polito, Giorgia, Maresca, Rossella, Mezza, Teresa, Schepis, Tommaso, Pellegrino, Antonio Agostino, Zileri Dal Verme, Lorenzo, Nicoletti, Alberto, Franceschi, Francesco, Gasbarrini, Antonio, Nista, Enrico Celestino, Candelli, Marcello (ORCID:0000-0001-8443-7880), Mezza, Teresa (ORCID:0000-0001-5407-9576), Pellegrino, Antonio, Franceschi, Francesco (ORCID:0000-0001-6266-445X), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823) more...
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The nutritional management of acute pancreatitis (AP) patients has widely changed over time. The "pancreatic rest" was the cornerstone of the old paradigm, and nutritional support was not even included in AP management. Traditional management of AP was based on intestinal rest, with or without complete parenteral feeding. Recently, evidence-based data underlined the superiority of early oral or enteral feeding with significantly decreased multiple-organ failure, systemic infections, surgery need, and mortality rate. Despite the current recommendations, experts still debate the best route for enteral nutritional support and the best enteral formula. The aim of this work is to collect and analyze evidence over the nutritional aspects of AP management to investigate its impact. Moreover, the role of immunonutrition and probiotics in modulating inflammatory response and gut dysbiosis during AP was extensively studied. However, we have no significant data for their use in clinical practice. This is the first work to move beyond the mere opposition between the old and the new paradigm, including an analysis of several topics still under debate in order to provide a comprehensive overview of nutritional management of AP. more...
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- 2023
29. Diagnostic and Prognostic Role of Extracellular Vesicles in Pancreatic Cancer: Current Evidence and Future Perspectives
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Nicoletti, Alberto, Negri, Marcantonio, Paratore, Mattia, Vitale, Federica, Ainora, Maria Elena, Nista, Enrico Celestino, Gasbarrini, Antonio, Zocco, Maria Assunta, Zileri Dal Verme, Lorenzo, Negri, Marcantonio (ORCID:0000-0001-7734-0538), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Zocco, Maria Assunta (ORCID:0000-0002-0814-9542), Nicoletti, Alberto, Negri, Marcantonio, Paratore, Mattia, Vitale, Federica, Ainora, Maria Elena, Nista, Enrico Celestino, Gasbarrini, Antonio, Zocco, Maria Assunta, Zileri Dal Verme, Lorenzo, Negri, Marcantonio (ORCID:0000-0001-7734-0538), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Zocco, Maria Assunta (ORCID:0000-0002-0814-9542) more...
- Abstract
Pancreatic cancer is one of the most aggressive tumors, with a dismal prognosis due to poor detection rates at early stages, rapid progression, post-surgical complications, and limited effectiveness of conventional oncologic therapies. There are no consistently reliable biomarkers or imaging modalities to accurately diagnose, classify, and predict the biological behavior of this tumor. Therefore, it is imperative to develop new and improved strategies to detect pancreatic lesions in the early stages of cancerization with greater sensitivity and specificity. Extracellular vesicles, including exosome and microvesicles, are membrane-coated cellular products that are released in the outer environment. All cells produce extracellular vesicles; however, this process is enhanced by inflammation and tumorigenesis. Based on accumulating evidence, extracellular vesicles play a crucial role in pancreatic cancer progression and chemoresistance. Moreover, they may represent potential biomarkers and promising therapy targets. The aim of the present review is to review the current evidence on the role of extracellular vesicles in pancreatic cancer. more...
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- 2023
30. Endoscopic pancreatic sphincterotomy in patients with IPMN-related recurrent pancreatitis: A single center experience
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Schepis, Tommaso, Tringali, Andrea, D'Aversa, F, Perri, Vincenzo, Familiari, Pietro, Boskoski, Ivo, Nista, Enrico Celestino, Costamagna, Guido, Schepis, T, Tringali, A (ORCID:0000-0002-9614-3449), Perri, V (ORCID:0000-0002-0551-0873), Familiari, P (ORCID:0000-0002-5181-2928), Boškoski, I (ORCID:0000-0001-8194-2670), Nista, E C, Costamagna, G (ORCID:0000-0002-8100-2731), Schepis, Tommaso, Tringali, Andrea, D'Aversa, F, Perri, Vincenzo, Familiari, Pietro, Boskoski, Ivo, Nista, Enrico Celestino, Costamagna, Guido, Schepis, T, Tringali, A (ORCID:0000-0002-9614-3449), Perri, V (ORCID:0000-0002-0551-0873), Familiari, P (ORCID:0000-0002-5181-2928), Boškoski, I (ORCID:0000-0001-8194-2670), Nista, E C, and Costamagna, G (ORCID:0000-0002-8100-2731) more...
- Abstract
Acute recurrent pancreatitis (ARP) is a rare manifestation of Intraductal Papillary Mucinous Neoplasms (IPMN) of the pancreas; ARP is a relative indication for pancreatic surgery in the setting of IPMN. Endoscopic pancreatic sphincterotomy (EPS) has been described as a minimal invasive treatment to reduce the episodes of ARP secondary to mucus migration in IPMN. more...
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- 2023
31. Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review
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Del Gaudio, Angelo, Covello, Carlo, Di Vincenzo, Federica, De Lucia, Sara Sofia, Mezza, Teresa, Nicoletti, Alberto, Siciliano, V., Candelli, Marcello, Gasbarrini, Antonio, Nista, Enrico Celestino, Del Gaudio A., Covello C., Di Vincenzo F., De Lucia S. S., Mezza T. (ORCID:0000-0001-5407-9576), Nicoletti A., Candelli M. (ORCID:0000-0001-8443-7880), Gasbarrini A. (ORCID:0000-0002-7278-4823), Nista E. C., Del Gaudio, Angelo, Covello, Carlo, Di Vincenzo, Federica, De Lucia, Sara Sofia, Mezza, Teresa, Nicoletti, Alberto, Siciliano, V., Candelli, Marcello, Gasbarrini, Antonio, Nista, Enrico Celestino, Del Gaudio A., Covello C., Di Vincenzo F., De Lucia S. S., Mezza T. (ORCID:0000-0001-5407-9576), Nicoletti A., Candelli M. (ORCID:0000-0001-8443-7880), Gasbarrini A. (ORCID:0000-0002-7278-4823), and Nista E. C. more...
- Abstract
Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can be caused by drugs, with a prevalence of up to 5%. Causal associations between drugs and pancreatitis are largely based on case reports or case series with limited evidence. We reviewed the available data on drug-induced AP, focusing on antimicrobial drugs and antivirals, and discussed the current evidence in relation to the classification systems available in the literature. We found 51 suspected associations between antimicrobial and antiviral drugs and AP. The drugs with the most evidence of correlation are didanosine, protease inhibitors, and metronidazole. In addition, other drugs have been described in case reports demonstrating positive rechallenge. However, there are major differences between the various classifications available, where the same drug being assigned to different probability classes. It is likely that the presence in multiple case reports of an association between acute pancreatitis and a drug should serve as a basis for conducting prospective randomized controlled trials to improve the quality of the evidence. more...
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- 2023
32. Antibiotic Utilization in Acute Pancreatitis: A Narrative Review
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Severino, Andrea, Varca, Simone, Airola, Carlo, Mezza, Teresa, Gasbarrini, Antonio, Franceschi, Francesco, Candelli, Marcello, Nista, Enrico Celestino, Severino A., Varca S., Airola C., Mezza T. (ORCID:0000-0001-5407-9576), Gasbarrini A. (ORCID:0000-0002-7278-4823), Franceschi F. (ORCID:0000-0001-6266-445X), Candelli M. (ORCID:0000-0001-8443-7880), Nista E. C., Severino, Andrea, Varca, Simone, Airola, Carlo, Mezza, Teresa, Gasbarrini, Antonio, Franceschi, Francesco, Candelli, Marcello, Nista, Enrico Celestino, Severino A., Varca S., Airola C., Mezza T. (ORCID:0000-0001-5407-9576), Gasbarrini A. (ORCID:0000-0002-7278-4823), Franceschi F. (ORCID:0000-0001-6266-445X), Candelli M. (ORCID:0000-0001-8443-7880), and Nista E. C. more...
- Abstract
Acute pancreatitis is a complex inflammatory disease with significant morbidity and mortality. Despite advances in its management, the role of antibiotics in the prophylaxis and treatment of acute pancreatitis remains controversial. The aim of this comprehensive review is to analyze current evidence on the use of antibiotics in acute pancreatitis, focusing on prophylactic and therapeutic strategies. Prophylactic use aims to prevent local and systemic infections. However, recent studies have questioned the routine use of antibiotics for prophylaxis and highlighted the potential risks of antibiotic resistance and adverse effects. In selected high-risk cases, such as infected necrotizing pancreatitis, prophylactic antibiotic therapy may still be beneficial. As for therapeutic use, antibiotics are usually used to treat infected pancreatic necrosis and extrapancreatic infections. When selecting an antibiotic, the microbiologic profile and local resistance patterns should be considered. Combination therapy with broad-spectrum antibiotics is often recommended to cover both Gram-positive and Gram-negative pathogens. Recent research has highlighted the importance of individualized approaches to antibiotic use in acute pancreatitis and underscored the need for a tailored approach based on patient-specific factors. This review also highlights the potential role of new antimicrobial agents and alternative strategies, such as probiotics, in the management of acute pancreatitis. more...
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- 2023
33. Effects of functional foods, nutraceuticals, and herbal products on pancreas
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Saviano, Angela, Zanza, C., Longhitano, Y., Nista, Enrico Celestino, Franceschi, Francesco, Ojetti, Veronica, Saviano A. (ORCID:0000-0002-2820-7180), Nista E. C., Franceschi F. (ORCID:0000-0001-6266-445X), Ojetti V. (ORCID:0000-0002-8953-0707), Saviano, Angela, Zanza, C., Longhitano, Y., Nista, Enrico Celestino, Franceschi, Francesco, Ojetti, Veronica, Saviano A. (ORCID:0000-0002-2820-7180), Nista E. C., Franceschi F. (ORCID:0000-0001-6266-445X), and Ojetti V. (ORCID:0000-0002-8953-0707) more...
- Abstract
N/A
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- 2023
34. Nutrition in Acute Pancreatitis: From the Old Paradigm to the New Evidence
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De Lucia, Sara Sofia, primary, Candelli, Marcello, additional, Polito, Giorgia, additional, Maresca, Rossella, additional, Mezza, Teresa, additional, Schepis, Tommaso, additional, Pellegrino, Antonio, additional, Zileri Dal Verme, Lorenzo, additional, Nicoletti, Alberto, additional, Franceschi, Francesco, additional, Gasbarrini, Antonio, additional, and Nista, Enrico Celestino, additional more...
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- 2023
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35. Effects of functional foods, nutraceuticals, and herbal products on pancreas?
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Saviano, Angela, primary, Zanza, Christian, additional, Longhitano, Yaroslava, additional, Nista, Enrico Celestino, additional, Franceschi, Francesco, additional, and Ojetti, Veronica, additional
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- 2023
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36. Pancreatic Cancer Resistance to Treatment: The Role of Microbiota
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Nista, Enrico Celestino, primary, Del Gaudio, Angelo, additional, Del Vecchio, Livio Enrico, additional, Mezza, Teresa, additional, Pignataro, Giulia, additional, Piccioni, Andrea, additional, Gasbarrini, Antonio, additional, Franceschi, Francesco, additional, and Candelli, Marcello, additional more...
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- 2023
- Full Text
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37. Diagnostic and Prognostic Role of Extracellular Vesicles in Pancreatic Cancer: Current Evidence and Future Perspectives
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Nicoletti, Alberto, primary, Negri, Marcantonio, additional, Paratore, Mattia, additional, Vitale, Federica, additional, Ainora, Maria Elena, additional, Nista, Enrico Celestino, additional, Gasbarrini, Antonio, additional, Zocco, Maria Assunta, additional, and Zileri Dal Verme, Lorenzo, additional more...
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- 2023
- Full Text
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38. Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features
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Capece, Umberto, primary, Moffa, Simona, additional, Improta, Ilaria, additional, Di Giuseppe, Gianfranco, additional, Nista, Enrico Celestino, additional, Cefalo, Chiara M. A., additional, Cinti, Francesca, additional, Pontecorvi, Alfredo, additional, Gasbarrini, Antonio, additional, Giaccari, Andrea, additional, and Mezza, Teresa, additional more...
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- 2022
- Full Text
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39. A single bout of physical exercise improves 1-hour post-load plasma glucose in healthy young adults
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Moffa, Simona, Sorice, Gian Pio, Di Giuseppe, Gianfranco, Cinti, Francesca, Ciccarelli, Gea, Soldovieri, Laura, Brunetti, Michela, Sonnino, Rebecca, Nista, Enrico C., Gasbarrini, Antonio, Pontecorvi, Alfredo, Mezza, Teresa, and Giaccari, Andrea more...
- Abstract
Purpose: Physical exercise is a key component in the treatment of type 2 diabetes and plays an important role in maintaining a healthy glucose metabolism even in healthy subjects. To date, no studies have investigated the effect of a single bout of aerobic physical exercise on glucose metabolism in young, moderately active, healthy adults. Methods: We performed an OGTT 7 days before and 24 h after a single bout of physical exercise, to evaluate 1-hour post-load plasma glucose and surrogate indexes of insulin sensitivity and insulin secretion. Results: Glucose levels were significantly reduced after exercise at baseline and one hour after glucose load; similarly, insulin was significantly lower 1 h after glucose load. We found a significant increase in the Matsuda index, confirmed by OGIS index, QUICKI index, and by significant reduction in HOMA-IR. Conversely, we observed a trend to increase in HOMA-B. Conclusion: This is the first study to evaluate the effect of a single bout of exercise on 1-hour glucose levels following OGTT. We found a significant reduction in 1-hour glucose levels following OGTT together with an increased insulin sensitivity. A single 30-minute bout of aerobic exercise also seemed to improve the insulin secretion pattern. Modifications in beta cell secretory capacity during exercise are likely secondary to an improvement in insulin action in insulin dependent tissues. more...
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- 2024
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40. Clinical Implications of Helicobacter pylori Antibiotic Resistance in Italy: A Review of the Literature
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Nista, Enrico Celestino, primary, Pellegrino, Antonio, additional, Giuli, Lucia, additional, Candelli, Marcello, additional, Schepis, Tommaso, additional, De Lucia, Sara Sofia, additional, Ojetti, Veronica, additional, Franceschi, Francesco, additional, and Gasbarrini, Antonio, additional more...
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- 2022
- Full Text
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41. Autoimmune Pancreatitis: From Pathogenesis to Treatment
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Nista, Enrico Celestino, primary, De Lucia, Sara Sofia, additional, Manilla, Vittoria, additional, Schepis, Tommaso, additional, Pellegrino, Antonio, additional, Ojetti, Veronica, additional, Pignataro, Giulia, additional, Zileri dal Verme, Lorenzo, additional, Franceschi, Francesco, additional, Gasbarrini, Antonio, additional, and Candelli, Marcello, additional more...
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- 2022
- Full Text
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42. Risk factors for the occurrence of ampullary tumors: A case‐control study
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Zaccari, Piera, primary, Archibugi, Livia, additional, Belfiori, Giulio, additional, Nista, Enrico, additional, dell'Anna, Giuseppe, additional, Crippa, Stefano, additional, Schepis, Tommaso, additional, Tacelli, Matteo, additional, Aleotti, Francesca, additional, Petrone, Maria Chiara, additional, Mariani, Alberto, additional, Costamagna, Guido, additional, Gasbarrini, Antonio, additional, Larghi, Alberto, additional, Falconi, Massimo, additional, Arcidiacono, Paolo Giorgio, additional, and Capurso, Gabriele, additional more...
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- 2022
- Full Text
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43. Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features
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Capece, Umberto, Moffa, Simona, Improta, I., Di Giuseppe, Gianfranco, Nista, Enrico Celestino, Cefalo, Chiara Maria Assunta, Cinti, Francesca, Pontecorvi, Alfredo, Gasbarrini, Antonio, Giaccari, Andrea, Mezza, Teresa, Capece U., Moffa S., Di Giuseppe G., Nista E. C., Cefalo C. M. A., Cinti F. (ORCID:0000-0001-5170-7055), Pontecorvi A. (ORCID:0000-0003-0570-6865), Gasbarrini A. (ORCID:0000-0002-7278-4823), Giaccari A. (ORCID:0000-0002-7462-7792), Mezza T. (ORCID:0000-0001-5407-9576), Capece, Umberto, Moffa, Simona, Improta, I., Di Giuseppe, Gianfranco, Nista, Enrico Celestino, Cefalo, Chiara Maria Assunta, Cinti, Francesca, Pontecorvi, Alfredo, Gasbarrini, Antonio, Giaccari, Andrea, Mezza, Teresa, Capece U., Moffa S., Di Giuseppe G., Nista E. C., Cefalo C. M. A., Cinti F. (ORCID:0000-0001-5170-7055), Pontecorvi A. (ORCID:0000-0003-0570-6865), Gasbarrini A. (ORCID:0000-0002-7278-4823), Giaccari A. (ORCID:0000-0002-7462-7792), and Mezza T. (ORCID:0000-0001-5407-9576) more...
- Abstract
Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in patients with diabetic polyneuropathy due to its positive effects on nerve conduction and alleviation of symptoms. It is, moreover, also prescribed in other insulin resistance conditions such as metabolic syndrome (SM), polycystic ovary syndrome (PCOS) and obesity. However, several cases of Insulin Autoimmune Syndrome (IAS) have been reported in subjects taking ALA. The aim of the present review is to describe the main chemical and biological functions of ALA in glucose metabolism, focusing on its antioxidant activity, its role in modulating insulin sensitivity and secretion and in symptomatic peripheral diabetic polyneuropathy. We also provide a potential explanation for increased risk for the development of IAS. more...
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- 2022
44. Clinical Implications of Helicobacter pylori Antibiotic Resistance in Italy: A Review of the Literature
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Nista, Enrico Celestino, Pellegrino, Antonio Agostino, Giuli, Lucia, Candelli, Marcello, Schepis, Tommaso, De Lucia, Sara Sofia, Ojetti, Veronica, Franceschi, Francesco, Gasbarrini, Antonio, Pellegrino, Antonio, Candelli, Marcello (ORCID:0000-0001-8443-7880), Ojetti, Veronica (ORCID:0000-0002-8953-0707), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Nista, Enrico Celestino, Pellegrino, Antonio Agostino, Giuli, Lucia, Candelli, Marcello, Schepis, Tommaso, De Lucia, Sara Sofia, Ojetti, Veronica, Franceschi, Francesco, Gasbarrini, Antonio, Pellegrino, Antonio, Candelli, Marcello (ORCID:0000-0001-8443-7880), Ojetti, Veronica (ORCID:0000-0002-8953-0707), Franceschi, Francesco (ORCID:0000-0001-6266-445X), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823) more...
- Abstract
Helicobacter pylori (H. pylori) resistance to antibiotics has increased worldwide in recent decades, especially to clarithromycin. As a result, the World Health Organization (WHO) identified clarithromycin-resistant H. pylori as a "high priority" pathogen in 2017. As international guidelines recommend empirical therapy as first-line treatment, it is crucial to know local resistance rates and history of antibiotic use to determine the most appropriate first-line antibiotic treatment. Italy is one of the European countries with the highest prevalence of H. pylori infection and the highest percentage of antibiotic-resistant H. pylori. The aim of this review is to summarize all data on H. pylori antibiotic resistance in Italy in order to quantify the current rate and determine the most effective therapeutic approach. The study confirms an elevated level of resistance to clarithromycin, metronidazole, and levofloxacin in Italy. In addition, our results show a satisfactory eradication rate for a bismuth-based regimen when used as first- or second-line treatment. Naive patients are also successfully treated with clarithromycin-based quadruple therapies. Considering the good results of bismuth-based therapy as recovery therapy, this argues for the potential use of clarithromycin quadruple therapy as a first-line treatment. more...
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- 2022
45. Autoimmune Pancreatitis: From Pathogenesis to Treatment
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Nista, Enrico Celestino, De Lucia, Sara Sofia, Manilla, Vittoria, Schepis, Tommaso, Pellegrino, Antonio Agostino, Ojetti, Veronica, Pignataro, Giulia, Zileri Dal Verme, Lorenzo, Franceschi, Francesco, Gasbarrini, Antonio, Candelli, Marcello, Pellegrino, Antonio, Ojetti, Veronica (ORCID:0000-0002-8953-0707), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Candelli, Marcello (ORCID:0000-0001-8443-7880), Nista, Enrico Celestino, De Lucia, Sara Sofia, Manilla, Vittoria, Schepis, Tommaso, Pellegrino, Antonio Agostino, Ojetti, Veronica, Pignataro, Giulia, Zileri Dal Verme, Lorenzo, Franceschi, Francesco, Gasbarrini, Antonio, Candelli, Marcello, Pellegrino, Antonio, Ojetti, Veronica (ORCID:0000-0002-8953-0707), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Candelli, Marcello (ORCID:0000-0001-8443-7880) more...
- Abstract
Autoimmune pancreatitis (AIP) is a rare disease. The diagnosis of AIP is difficult and should be made by a comprehensive evaluation of clinical, radiological, serological, and pathological findings. Two different types of AIP have been identified: autoimmune pancreatitis type 1 (AIP-1), which is considered a pancreatic manifestation of multiorgan disease related to IgG4, and autoimmune pancreatitis type 2 (AIP-2), which is considered a pancreas-specific disease not related to IgG4. Although the pathophysiological conditions seem to differ between type 1 and type 2 pancreatitis, both respond well to steroid medications. In this review, we focused on the pathogenesis of the disease to develop a tool that could facilitate diagnosis and lead to the discovery of new therapeutic strategies to combat autoimmune pancreatitis and its relapses. The standard therapy for AIP is oral administration of corticosteroids. Rituximab (RTX) has also been proposed for induction of remission and maintenance therapy in relapsing AIP-1. In selected patients, immunomodulators such as azathioprine are used to maintain remission. The strength of this review, compared with previous studies, is that it focuses on the clear difference between the two types of autoimmune pancreatitis with a clearly delineated and separate pathogenesis. In addition, the review also considers various therapeutic options, including biologic drugs, such as anti-tumor necrosis factor (TNF) therapy, a well-tolerated and effective second-line therapy for AIP type 2 relapses or steroid dependence. Other biologic therapies are also being explored that could provide a useful therapeutic alternative to corticosteroids and immunosuppressants, which are poorly tolerated due to significant side effects. more...
- Published
- 2022
46. Metabolic implications of pancreatic steatosis: insights and correlation analysis with mri findings.
- Author
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De Lucia, Sara Sofia, Nista, Enrico Celestino, Soldovieri, Laura, Genco, Enza, Brizi, Maria Gabriella, Sessa, Filippo Maria, Gori, Elisabetta, Di Giuseppe, Gianfranco, Palumbo, Giulia, Gasbarrini, Antonio, and Mezza, Teresa more...
- Published
- 2024
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47. Microbiota in Pancreatic Diseases: A Review of the Literature
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Schepis, Tommaso, primary, De Lucia, Sara S., additional, Nista, Enrico C., additional, Manilla, Vittoria, additional, Pignataro, Giulia, additional, Ojetti, Veronica, additional, Piccioni, Andrea, additional, Gasbarrini, Antonio, additional, Franceschi, Francesco, additional, and Candelli, Marcello, additional more...
- Published
- 2021
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48. Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features.
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Capece, Umberto, Moffa, Simona, Improta, Ilaria, Di Giuseppe, Gianfranco, Nista, Enrico Celestino, Cefalo, Chiara M. A., Cinti, Francesca, Pontecorvi, Alfredo, Gasbarrini, Antonio, Giaccari, Andrea, and Mezza, Teresa more...
- Abstract
Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in patients with diabetic polyneuropathy due to its positive effects on nerve conduction and alleviation of symptoms. It is, moreover, also prescribed in other insulin resistance conditions such as metabolic syndrome (SM), polycystic ovary syndrome (PCOS) and obesity. However, several cases of Insulin Autoimmune Syndrome (IAS) have been reported in subjects taking ALA. The aim of the present review is to describe the main chemical and biological functions of ALA in glucose metabolism, focusing on its antioxidant activity, its role in modulating insulin sensitivity and secretion and in symptomatic peripheral diabetic polyneuropathy. We also provide a potential explanation for increased risk for the development of IAS. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
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49. Humoral Predictors of Malignancy in IPMN: A Review of the Literature
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Nista, Enrico C., primary, Schepis, Tommaso, additional, Candelli, Marcello, additional, Giuli, Lucia, additional, Pignataro, Giulia, additional, Franceschi, Francesco, additional, Gasbarrini, Antonio, additional, and Ojetti, Veronica, additional more...
- Published
- 2021
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50. COVID-19 and intestinal inflammation: Role of fecal calprotectin
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Abbate, Valeria, Acampora, Nicola, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Antonelli, Mariangela, Antonucci, Gabriele, Anzellotti, Gian Marco, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Barone, Fabiana, Bellantone, Rocco Domenico Alfonso, Bellieni, Andrea, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Bibbò, Stefano, Bini, Alessandra, Bisanti, Alessandra, Biscetti, Federico, Bocci, Maria Grazia, Bonadia, Nicola, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Bruni, Teresa, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Burzo, Livia, Calabrese, Angelo, Calvello, Maria Rosaria, Cambieri, Andrea, Cambise, Chiara, Cammà, Giulia, Candelli, Marcello, Canistro, Gennaro, Cantanale, Antonello, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Cardone, Silvia, Carelli, Simone, Carfì, Angelo, Carnicelli, Annamaria, Caruso, Cristiano, Casciaro, Francesco Antonio, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Cesarano, Melania, Chiarito, Annalisa, Cianci, Rossella, Cicchinelli, Sara, Ciccullo, Arturo, Cicetti, Marta, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Maria Ludovica, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Costanzi, Matteo, Covino, Marcello, Crupi, Davide, Cutuli, Salvatore Lucio, D'Addio, Stefano, D'Alessandro, Alessia, D'AlfonsoD'Angelo, Maria ElenaEmanuela, D'Aversa, Francesca, Damiano, Fernando, De Berardinis, Gian Maria, De Cunzo, Tommaso, De Gaetano, Donati Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Santis, Paolo, De Siena, Martina, De Vito, Francesco, Del Gatto, Valeria, Del Giacomo, Paola, Del Zompo, Fabio, Dell'Anna, Antonio Maria, Polla, Davide Della, Di Gialleonardo, Luca, Di Giambenedetto, Simona, Di Luca, Roberta, Di Maurizio, Luca, Di Muro, Mariangela, Dusina, Alex, Eleuteri, Davide, Esperide, Alessandra, Fachechi, Daniele, Faliero, Domenico, Falsiroli, Cinzia, Fantoni, Massimo, Fedele, Annalaura, Feliciani, Daniela, Ferrante, Cristina, Ferrone, Giuliano, Festa, Rossano, Fiore, Maria Chiara, Flex, Andrea, Forte, Evelina, Franceschi, Francesco, Francesconi, Alessandra, Franza, Laura, Funaro, Barbara, Fuorlo, Mariella, Fusco, Domenico, Gabrielli, Maurizio, Gaetani, Eleonora, Galletta, Claudia, Gallo, Antonella, Gambassi, Giovanni, Garcovich, Matteo, Gasbarrini, Antonio, Gasparrini, Irene, Gelli, Silvia, Giampietro, Antonella, Gigante, Laura, Giuliano, Gabriele, Giuliano, Giorgia, Giupponi, Bianca, Gremese, Elisa, Grieco, Domenico Luca, Guerrera, Manuel, Guglielmi, Valeria, Guidone, Caterina, Gullì, Antonio, Iaconelli, Amerigo, Iafrati, Aurora, Ianiro, Gianluca, Iaquinta, Angela, Impagnatiello, Michele, Inchingolo, Riccardo, Intini, Enrica, Iorio, Raffaele, Izzi, Immacolata Maria, Jovanovic, Tamara, Kadhim, Cristina, La Macchia, Rosa, La Milia, Daniele Ignazio, Landi, Francesco, Landi, Giovanni, Landi, Rosario, Landolfi, Raffaele, Leo, Massimo, Leone, Paolo Maria, Levantesi, Laura, Liguori, Antonio, Liperoti, Rosa, Lizzio, Marco Maria, Monaco, Maria Rita Lo, Locantore, Pietro, Lombardi, Francesco, Lombardi, Gianmarco, Lopetuso, Loris, Loria, Valentina, Losito, Angela Raffaella, Lucia, Mothanje Barbara Patricia, Macagno, Francesco, Macerola, Noemi, Maggi, Giampaolo, Maiuro, Giuseppe, Mancarella, Francesco, Mangiola, Francesca, Manno, Alberto, Marchesini, Debora, Maresca, Gian Marco, Marrone, Giuseppe, Martis, Ilaria, Martone, Anna Maria, Marzetti, Emanuele, Mattana, Chiara, Matteo, Maria Valeria, Maviglia, Riccardo, Mazzarella, Ada, Memoli, Carmen, Miele, Luca, Migneco, Alessio, Mignini, Irene, Milani, Alessandro, Milardi, Domenico, Montalto, Massimo, Montemurro, Giuliano, Monti, Flavia, Montini, Luca, Morena, Tony Christian, Morra, Vincenzina, Morretta, Chiara, Moschese, Davide, Murace, Celeste Ambra, Murdolo, Martina, Murri, Rita, Napoli, Marco, Nardella, Elisabetta, Natalello, Gerlando, Natalini, Daniele, Navarra, Simone Maria, Nesci, Antonio, Nicoletti, Alberto, Nicoletti, Rocco, Nicoletti, Tommaso Filippo, Nicolò, Rebecca, Nicolotti, Nicola, Nista, Enrico Celestino, Nuzzo, Eugenia, Oggiano, Marco, Ojetti, Veronica, Pagano, Francesco Cosimo, Paiano, Gianfranco, Pais, Cristina, Pallavicini, Federico, Palombo, Andrea, Paolillo, Federico, Papa, Alfredo, Papanice, Domenico, Papparella, Luigi Giovanni, Paratore, Mattia, Parrinello, Giuseppe, Pasciuto, Giuliana, Pasculli, Pierpaolo, Pecorini, Giovanni, Perniola, Simone, Pero, Erika, Petricca, Luca, Petrucci, Martina, Picarelli, Chiara, Piccioni, Andrea, Piccolo, Annalisa, Piervincenzi, Edoardo, Pignataro, Giulia, Pignataro, Raffaele, Pintaudi, Gabriele, Pisapia, Luca, Pizzoferrato, Marco, Pizzolante, Fabrizio, Pola, Roberto, Policola, Caterina, Pompili, Maurizio, Pontecorvi, Flavia, Pontecorvi, Valerio, Ponziani, Francesca, Popolla, Valentina, Porceddu, Enrica, Porfidia, Angelo, Porro, Lucia Maria, Potenza, Annalisa, Pozzana, Francesca, Privitera, Giuseppe, Pugliese, Daniela, Pulcini, Gabriele, Racco, Simona, Raffaelli, Francesca, Ramunno, Vittoria, Rapaccini, Gian Ludovico, Richeldi, Luca, Rinninella, Emanuele, Rocchi, Sara, Romanò, Bruno, Romano, Stefano, Rosa, Federico, Rossi, Laura, Rossi, Raimondo, Rossini, Enrica, Rota, Elisabetta, Rovedi, Fabiana, Rubino, Carlotta, Rumi, Gabriele, Russo, Andrea, Sabia, Luca, Salerno, Andrea, Salini, Sara, Salvatore, Lucia, Samori, Dehara, Sandroni, Claudio, Sanguinetti, Maurizio, Santarelli, Luca, Santini, Paolo, Santolamazza, Danilo, Santoliquido, Angelo, Santopaolo, Francesco, Santoro, Michele Cosimo, Sardeo, Francesco, Sarnari, Caterina, Saviano, Angela, Saviano, Luisa, Scaldaferri, Franco, Scarascia, Roberta, Schepis, Tommaso, Schiavello, Francesca, Scoppettuolo, Giancarlo, Sedda, Davide, Sessa, Flaminio, Sestito, Luisa, Settanni, Carlo, Siciliano, Matteo, Siciliano, Valentina, Sicuranza, Rossella, Simeoni, Benedetta, Simonetti, Jacopo, Smargiassi, Andrea, Soave, Paolo Maurizio, Sonnino, Chiara, Staiti, Domenico, Stella, Claudia, Stella, Leonardo, Stival, Eleonora, Taddei, Eleonora, Talerico, Rossella, Tamburello, Elio, Tamburrini, Enrica, Tanzarella, Eloisa Sofia, Tarascio, Elena, Tarli, Claudia, Tersali, Alessandra, Tilli, Pietro, Timpano, Jacopo, Torelli, Enrico, Torrini, Flavia, Tosato, Matteo, Tosoni, Alberto, Tricoli, Luca, Tritto, Marcello, Tumbarello, Mario, Tummolo, Anita Maria, Vallecoccia, Maria Sole, Valletta, Federico, Varone, Francesco, Vassalli, Francesco, Ventura, Giulio, Verardi, Lucrezia, Vetrone, Lorenzo, Vetrugno, Giuseppe, Visconti, Elena, Visconti, Felicia, Viviani, Andrea, Zaccaria, Raffaella, Zaccone, Carmelina, Zelano, Lorenzo, Dal Verme, Lorenzo Zileri, Zuccalà, Giuseppe, and Troiani, Eliana more...
- Published
- 2020
- Full Text
- View/download PDF
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