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1. Rheumatology

Author

Pilkington, Clarissa, primary, Nistala, Kiran, additional, Lachman, Helen, additional, and Brogan, Paul, additional

Published
2019
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2. Contributors

Author

Abramson, Steven, primary, An, KaiNan, additional, Andrade, Felipe, additional, Ardoin, Stacy P., additional, Barton, Anne, additional, Baughman, Robert P., additional, Beaton, Dorcas E., additional, Beere, Helen M., additional, Beltran, Javier, additional, Bending, David, additional, Bennett, Robert M., additional, Bermas, Bonnie L., additional, Bertsias, George, additional, Bhardwaj, Nina, additional, Bijlsma, Johannes W.J., additional, Bockenstedt, Linda K., additional, Boers, Maarten, additional, Boilard, Eric, additional, Boin, Francesco, additional, Boumpas, Dimitrios T., additional, Boyle, David L., additional, Bradley, Sean, additional, Brown, Matthew, additional, Buch, Maya, additional, Buckley, Christopher D., additional, Budd, Ralph C., additional, Burg, Nathalie, additional, Burns, Christopher M., additional, Cannella, Amy C., additional, Carter, John D., additional, Chakravarty, Eliza F., additional, Chakravarty, Soumya D., additional, Chang, Christopher, additional, Cheng, Joseph S., additional, Chiodo, Christopher P., additional, Chung, Sharon, additional, Cleland, Leslie G., additional, Cohen, Stanley, additional, Colbert, Robert A., additional, Cook, Paul P., additional, Craft, Joseph E., additional, Crofford, Leslie J., additional, Cronstein, Bruce N., additional, Crow, Mary K., additional, Crowson, Cynthia S., additional, Culley, Kirsty L., additional, Cunnane, Gaye, additional, Dall'Era, Maria, additional, Darrah, Erika, additional, Davis, John M., additional, Bari, Cosimo De, additional, Dell'Accio, Francesco, additional, Diamond, Betty, additional, Di Cesare, Paul E., additional, Dixit, Rajiv, additional, Drenth, Joost P.H., additional, Dustin, Michael L., additional, El-Gabalawy, Hani S., additional, Elmamoun, Musaab, additional, Erickson, Alan R., additional, Erkan, Doruk, additional, Eyre, Stephen, additional, Fanouriakis, Antonis, additional, Felson, David T., additional, Field, Max, additional, Filer, Andrew, additional, Firestein, Gary S., additional, Fishman, Felicity G., additional, FitzGerald, Oliver, additional, Flaherty, John P., additional, Fors, César E., additional, Fortner, Karen A., additional, Gabriel, Sherine E., additional, Gasque, Philippe, additional, Gershwin, M. Eric, additional, Gladue, Heather S., additional, Goldring, Mary B., additional, Goldring, Steven R., additional, Golightly, Yvonne M., additional, Goodman, Stuart, additional, Gordon, Siamon, additional, Grassi, Walter, additional, Green, Douglas R., additional, Greenspan, Adam, additional, Gregersen, Peter, additional, Grimaldi, Christine, additional, Guilherme, Luiza, additional, Hajj-Ali, Rula A., additional, Haudenschild, Dominik R., additional, Hellmann, David B., additional, Holmdahl, Rikard, additional, Hsu, Joyce J., additional, Huddleston, James I., additional, Hudson, Alan P., additional, Huizinga, Thomas W.J., additional, Hunder, Gene G., additional, Iversen, Maura D., additional, Jacobs, Johannes W.G., additional, Jen, Ho, additional, Jordan, Joanne M., additional, Jorizzo, Joseph L., additional, Kalil, Jorge, additional, Kaufman, Kenton, additional, Kaufman, William S., additional, Kavanaugh, Arthur, additional, Keenan, Robert T., additional, Kenna, Tony, additional, Kerr, Darcy A., additional, Koch, Alisa E., additional, Kono, Dwight H., additional, Korsten, Peter, additional, Krakow, Deborah, additional, Krasnokutsky, Svetlana, additional, Lafeber, Floris P.J.G., additional, Lambert, Robert G.W., additional, Lane, Nancy E., additional, Langford, Carol A., additional, Laskin, Daniel M., additional, Layh-Schmitt, Gerlinde, additional, Lee, Lela A., additional, Lee, Tzielan C., additional, Lockshin, Michael D., additional, Lozada, Carlos J., additional, Lundberg, Ingrid E., additional, Luqmani, Raashid, additional, Luyten, Frank P., additional, Mader, Reuven, additional, Maksymowych, Walter, additional, Markenson, Joseph A., additional, Martin, Scott David, additional, Matteson, Eric L., additional, McGregor, Laura, additional, McInnes, Iain B., additional, McNamara, Elizabeth K., additional, Mikuls, Ted R., additional, Miller, Mark S., additional, Ming, Pedro Azevedo, additional, Moder, Kevin G., additional, Monach, Paul A., additional, Moulton, Vaishali R., additional, Nagaraju, Kanneboyina, additional, Nelson, Amanda E., additional, Nigrovic, Peter A., additional, Nistala, Kiran, additional, O'Dell, James R., additional, Okada, Yasunori, additional, Østergaard, Mikkel, additional, Otero, Miguel, additional, Palmer, Bradley M., additional, Panush, Richard S., additional, Peng, Stanford L., additional, Pillai, Shiv, additional, Pillinger, Michael H., additional, Plüddemann, Annette, additional, Polston, Gregory R., additional, Porcelli, Steven A., additional, Price, Mark D., additional, Reed, Ann M., additional, Reveille, John D., additional, Robinson, Angela B., additional, Robinson, Philip, additional, Robinson, William H., additional, Roosendaal, Goris, additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rosenberg, Andrew E., additional, Ruderman, Eric M., additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Sammaritano, Lisa R., additional, Samuels, Jonathan, additional, Sandborg, Christy I., additional, Sawalha, Amr H., additional, Saxena, Amit, additional, Schett, Georg, additional, Schutgens, Roger E.G., additional, Seldin, David C., additional, Shah, Binita, additional, Sikora, Keith A., additional, Simon, Anna, additional, Siraj, Dawd S., additional, Sorkin, Linda S., additional, St. Clair, E. William, additional, Stamp, Lisa K., additional, Stone, John H., additional, Suarez-Fueyo, Abel, additional, Svensson, Camilla I., additional, Sweiss, Nadera J., additional, Swigart, Carrie R., additional, Szekanecz, Zoltán, additional, Tait, Stephen, additional, Tanne, Antoine, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Theofilopoulos, Argyrios N., additional, Thornhill, Thomas S., additional, Torok, Kathryn S., additional, Toth, Michael J., additional, Tozman, Elaine C., additional, Trouw, Leendert A., additional, Tsokos, George C., additional, Tugwell, Peter, additional, Tutuncu, Zuhre, additional, Upadhyaya, Shivam, additional, Van, Annette H.M., additional, van der Linden, Sjef, additional, Van, Jos W.M., additional, Van, Jacob M., additional, Meter, Heather Van, additional, van Vollenhoven, Ronald F., additional, van Vulpen, Lize F.D., additional, Varga, John, additional, Vaseer, Samera, additional, Vasquez-Castellanos, Raul, additional, Veale, Douglas J., additional, Wakefield, Richard J., additional, Wallace, Mark S., additional, Wang, Ruoning, additional, Wang, Tingting, additional, Warshaw, David M., additional, Wedderburn, Lucy R., additional, Werth, Victoria P., additional, Wigley, Fredrick M., additional, Wofsy, David, additional, Wollheim, Frank A., additional, Wondimu, Elisabeth, additional, Wong, Cyrus, additional, Wortmann, Robert L., additional, Yelin, Edward, additional, Zayat, Ahmed, additional, Zou, Yong-Rui, additional, and Zurier, Robert B., additional

Published
2017
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5. Consensus-based recommendations for the management of juvenile dermatomyositis

Author

Enders, Felicitas Bellutti, Bader-Meunier, Brigitte, Baildam, Eileen, Constantin, Tamas, Dolezalova, Pavla, Feldman, Brian M, Lahdenne, Pekka, Magnusson, Bo, Nistala, Kiran, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Russo, Ricardo, Uziel, Yosef, van Brussel, Marco, van der Net, Janjaap, Vastert, Sebastiaan, Wedderburn, Lucy R, Wulffraat, Nicolaas, McCann, Liza J, and van Royen-Kerkhof, Annet

Published
2017
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12. Contributors

Author

Abramson, Steven B., primary, An, Kai-Nan, additional, Andrade, Felipe, additional, Atkinson, John P., additional, Baeten, Dominique, additional, Baughman, Robert P., additional, Beaton, Dorcas E., additional, Bennett, Robert, additional, Benseler, Susanne M., additional, Bertsias, George, additional, Bhardwaj, Nina, additional, Bijlsma, Johannes W.J., additional, Bockenstedt, Linda K., additional, Boers, Maarten, additional, Boin, Francesco, additional, Boumpas, Dimitrios T., additional, Bresnihan, Barry, additional, Brettler, Doreen B., additional, Buckley, Christopher D., additional, Budd, Ralph C., additional, Burns, Christopher M., additional, Cannella, Amy C., additional, Chakravarty, Eliza F., additional, Chang, Christopher, additional, Cheng, Joseph S., additional, Chiodo, Christopher P., additional, Cleland, Leslie G., additional, Clowse, Megan E., additional, Cook, Paul P., additional, Craft, Joseph E., additional, Crofford, Leslie J., additional, Cronstein, Bruce N., additional, Crow, Mary K., additional, Cunnane, Gaye, additional, Cush, John J., additional, Cutolo, Maurizio, additional, Dall'Era, Maria, additional, Dao, Kathryn H., additional, Darrah, Erika, additional, Davis, John M., additional, DeGroot, Jeroen, additional, Devin, Clint, additional, Diamond, Betty, additional, Díaz-González, Federico, additional, Di Cesare, Paul E., additional, Dixit, Rajiv, additional, Drenth, Joost P.H., additional, Dustin, Michael L., additional, El-Gabalawy, Hani S., additional, Elkon, Keith B., additional, Erkan, Doruk, additional, Fanouriakis, Antonios, additional, Field, Max, additional, Filer, Andrew, additional, Firestein, Gary S., additional, Fitzgerald, Oliver, additional, Flaherty, John P., additional, Flanagan, Adrienne M., additional, Fortner, Karen A., additional, Gabriel, Sherine E., additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gershwin, M. Eric, additional, Gibofsky, Allan, additional, Ginsberg, Mark H., additional, Goldring, Mary B., additional, Goldring, Steven R., additional, Golightly, Yvonne M., additional, Goodman, Stuart, additional, Gordon, Siamon, additional, Grassi, Walter, additional, Greenspan, Adam, additional, Gregersen, Peter K., additional, Grimaldi, Christine, additional, Hajj-Ali, Rula A., additional, Harper, Lorraine, additional, Harris, Edward D., additional, Haudenschild, Dominik R., additional, Hellmann, David B., additional, Holmdahl, Rikard, additional, Hsu, Joyce J., additional, Huddleston, James I., additional, Huizinga, Thomas W.J., additional, Hunder, Gene G., additional, Hung, Emily W., additional, Inman, Robert D., additional, Iversen, Maura Daly, additional, Jacobs, Johannes W.G., additional, Jordan, Joanne M., additional, Jorizzo, Joseph L., additional, Kaufman, Kenton R., additional, Kaufman, William S., additional, Kavanaugh, Arthur, additional, Keenan, Robert T., additional, Khan, Shaukat, additional, Koch, Alisa E., additional, Kono, Dwight H., additional, Krakow, Deborah, additional, Lambert, Robert G.W., additional, Landewé, Robert B.M., additional, Lane, Nancy E., additional, Langford, Carol A., additional, Laskin, Daniel M., additional, Laxer, Ronald M., additional, Lee, David M., additional, Lee, Lela A., additional, Lee, Tzielan Chang, additional, Lockshin, Michael D., additional, Lories, Rik, additional, Lozada, Carlos J., additional, Lundberg, Ingrid E., additional, Luqmani, Raashid, additional, Luyten, Frank P., additional, Mader, Reuven, additional, Maksymowych, Walter P., additional, Mandell, Brian, additional, Martin, Scott David, additional, Matteson, Eric L., additional, McGirt, Matthew J., additional, McInnes, Iain B., additional, McNamara, Elizabeth Kaufman, additional, Mikuls, Ted R., additional, Miller, Mark S., additional, Moder, Kevin G., additional, Nagaraju, Kanneboyina, additional, Naides, Stanley J., additional, Nelson, Amanda E., additional, Nigrovic, Peter A., additional, Nistala, Kiran, additional, Nowatzky, Johannes, additional, O'Dell, James R., additional, Okada, Yasunori, additional, Orduño, Nataly Manjarrez, additional, Ospelt, Caroline, additional, Østergaard, Mikkel, additional, Palmer, Bradley M., additional, Panush, Richard S., additional, Peng, Stanford L., additional, Pillinger, Michael H., additional, Polston, Gregory R., additional, Porcelli, Steven A., additional, Price, Mark D., additional, Rasker, Johannes J., additional, Reveille, John D., additional, Roberts, W. Neal, additional, Ronneberger, Monika, additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rosenberg, Andrew E., additional, Ruderman, Eric M., additional, Ruutu, Merja, additional, Salmon, Jane E., additional, Samuels, Jonathan, additional, Sandborg, Christy I., additional, Savage, Caroline O.S., additional, Saxena, Amit, additional, Scher, Jose U., additional, Schett, Georg, additional, Seldin, David C., additional, Simon, Anna, additional, Siraj, Dawd S., additional, Skinner, Martha, additional, St. Clair, E. William, additional, Stamp, Lisa K., additional, Stone, John H., additional, Straub, Rainer H., additional, Sweeney, Susan E., additional, Sweiss, Nadera J., additional, Swigart, Carrie R., additional, Symmons, Deborah, additional, Szekanecz, Zoltan, additional, Tak, Paul-Peter, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Theofilopoulos, Argyrios N., additional, Thomas, Ranjeny, additional, Thornhill, Thomas S., additional, Torralba, Karina D., additional, Toth, Michael J., additional, Tugwell, Peter, additional, Tutuncu, Zuhre, additional, Upchurch, Katherine S., additional, van der Heijde, Désirée M.F.M., additional, van der Helm-van Mil, Annette H.M., additional, van der Linden, Sjef M., additional, van der Meer, Jos W.M., additional, van Laar, Jacob M., additional, Varga, John, additional, Wallace, Mark S., additional, Warshaw, David M., additional, Wedderburn, Lucy R., additional, Werth, Victoria P., additional, Wigley, Fredrick M., additional, Wise, Christopher M., additional, Wofsy, David, additional, Wolfe, Frederick, additional, Wollheim, Frank A., additional, Wortmann, Robert L., additional, Yelin, Edward, additional, Yu, David, additional, Zabriskie, John B., additional, Zurier, Robert B., additional, and Zuurmond, Anne-Marie, additional

Published
2013
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15. Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis

Author

Ruperto, Nicolino, Brunner, Hermine I., Quartier, Pierre, Constantin, Tamás, Wulffraat, Nico, Horneff, Gerd, Brik, Riva, McCann, Liza, Kasapcopur, Ozgur, Rutkowska-Sak, Lidia, Schneider, Rayfel, Berkun, Yackov, Calvo, Inmaculada, Erguven, Muferet, Goffin, Laurence, Hofer, Michael, Kallinich, Tilmann, Oliveira, Sheila K., Uziel, Yosef, Viola, Stefania, Nistala, Kiran, Wouters, Carine, Cimaz, Rolando, Ferrandiz, Manuel A., Flato, Berit, Gamir, Maria Luz, Kone-Paut, Isabelle, Grom, Alexei, Magnusson, Bo, Ozen, Seza, Sztajnbok, Flavio, Lheritier, Karine, Abrams, Ken, Kim, Dennis, Martini, Alberto, and Lovell, Daniel J.

Published
2012
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17. Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates

Author

Laffan, Susan B., primary, Thomson, Andrew S., additional, Mai, Shing, additional, Fishman, Cindy, additional, Kambara, Takahito, additional, Nistala, Kiran, additional, Raymond, James T., additional, Chen, Shugui, additional, Ramani, Thulasi, additional, Pageon, Laura, additional, Polsky, Rodd, additional, Watkins, Mark, additional, Ottolangui, Gemma, additional, White, John R., additional, Maier, Curtis, additional, Herdman, Michael, additional, and Bouma, Gerben, additional

Published
2020
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22. Development and validation of a composite disease activity score for measurement of muscle and skin involvement in juvenile dermatomyositis

Author

Rosina, Silvia, Consolaro, Alessandro, van Dijkhuizen, Pieter, Pistorio, Angela, Varnier, Giulia Camilla, Bovis, Francesca, Nistala, Kiran, Maillard, Susan, Civino, Adele, Tsitsami, Elena, de Inocencio, Jaime, Jelusic, Marija, Vojinovic, Jelena, Espada, Graciela, Makay, Balahan, Katsicas, Maria Martha, Pratsidou-Gertsi, Polixeni, Lazarevic, Dragana, Rao, Anand Prahalad, Pires Marafon, Denise, Martini, Alberto, Pilkington, Clarissa, Ruperto, Nicolino, Ravelli, Angelo, Rosina, Silvia, Consolaro, Alessandro, van Dijkhuizen, Pieter, Pistorio, Angela, Varnier, Giulia Camilla, Bovis, Francesca, Nistala, Kiran, Maillard, Susan, Civino, Adele, Tsitsami, Elena, de Inocencio, Jaime, Jelusic, Marija, Vojinovic, Jelena, Espada, Graciela, Makay, Balahan, Katsicas, Maria Martha, Pratsidou-Gertsi, Polixeni, Lazarevic, Dragana, Rao, Anand Prahalad, Pires Marafon, Denise, Martini, Alberto, Pilkington, Clarissa, Ruperto, Nicolino, and Ravelli, Angelo

Published
2019

23. Galectin-9 and CXCL10 as biomarkers for disease activity in juvenile dermatomyositis : a longitudinal cohort study and multi-cohort validation

Author

Wienke, Judith, Bellutti Enders, Felicitas, Lim, Johan, Mertens, Jorre S., van den Hoogen, Luuk L., Wijngaarde, Camiel A., Yeo, Joo Guan, Meyer, Alain, Otten, Henny G., Fritsch-Stork, Ruth D.E., Kamphuis, Sylvia S.M., Hoppenreijs, Esther P.A.H., Armbrust, Wineke, van den Berg, J. Merlijn, Hissink Muller, Petra C.E., Tekstra, Janneke, Hoogendijk, Jessica E., Deakin, Claire T., de Jager, Wilco, van Roon, Joël A.G., van der Pol, W. Ludo, Nistala, Kiran, Pilkington, Clarissa, de Visser, Marianne, Arkachaisri, Thaschawee, Radstake, Timothy R.D.J., van der Kooi, Anneke J., Nierkens, Stefan, Wedderburn, Lucy R., van Royen-Kerkhof, Annet, van Wijk, Femke, Wienke, Judith, Bellutti Enders, Felicitas, Lim, Johan, Mertens, Jorre S., van den Hoogen, Luuk L., Wijngaarde, Camiel A., Yeo, Joo Guan, Meyer, Alain, Otten, Henny G., Fritsch-Stork, Ruth D.E., Kamphuis, Sylvia S.M., Hoppenreijs, Esther P.A.H., Armbrust, Wineke, van den Berg, J. Merlijn, Hissink Muller, Petra C.E., Tekstra, Janneke, Hoogendijk, Jessica E., Deakin, Claire T., de Jager, Wilco, van Roon, Joël A.G., van der Pol, W. Ludo, Nistala, Kiran, Pilkington, Clarissa, de Visser, Marianne, Arkachaisri, Thaschawee, Radstake, Timothy R.D.J., van der Kooi, Anneke J., Nierkens, Stefan, Wedderburn, Lucy R., van Royen-Kerkhof, Annet, and van Wijk, Femke

Published
2019

24. Development and validation of a composite disease activity score for measurement of muscle and skin involvement in juvenile dermatomyositis

Author

Arts-assistenten Kinderen, Rosina, Silvia, Consolaro, Alessandro, van Dijkhuizen, Pieter, Pistorio, Angela, Varnier, Giulia Camilla, Bovis, Francesca, Nistala, Kiran, Maillard, Susan, Civino, Adele, Tsitsami, Elena, de Inocencio, Jaime, Jelusic, Marija, Vojinovic, Jelena, Espada, Graciela, Makay, Balahan, Katsicas, Maria Martha, Pratsidou-Gertsi, Polixeni, Lazarevic, Dragana, Rao, Anand Prahalad, Pires Marafon, Denise, Martini, Alberto, Pilkington, Clarissa, Ruperto, Nicolino, Ravelli, Angelo, Arts-assistenten Kinderen, Rosina, Silvia, Consolaro, Alessandro, van Dijkhuizen, Pieter, Pistorio, Angela, Varnier, Giulia Camilla, Bovis, Francesca, Nistala, Kiran, Maillard, Susan, Civino, Adele, Tsitsami, Elena, de Inocencio, Jaime, Jelusic, Marija, Vojinovic, Jelena, Espada, Graciela, Makay, Balahan, Katsicas, Maria Martha, Pratsidou-Gertsi, Polixeni, Lazarevic, Dragana, Rao, Anand Prahalad, Pires Marafon, Denise, Martini, Alberto, Pilkington, Clarissa, Ruperto, Nicolino, and Ravelli, Angelo

Published
2019

25. Galectin-9 and CXCL10 as biomarkers for disease activity in juvenile dermatomyositis: a longitudinal cohort study and multi-cohort validation

Author

UMC Utrecht, CTI Van Wijk, Translationele immunologie, Infection & Immunity, Opleiding Neurologie, Brain, CDL Patiëntenzorg MI, CDL Celdiagnostiek, MS Reumatologie/Immunologie/Infectie, ZL Neuromusculaire Ziekten Medisch, CTI, CTI Radstake, CTI Research, CTI Nierkens, CTI UDAIR, Immuno/reuma patientenzorg, Child Health, Immuno/reuma onderzoek 4, Wienke, Judith, Bellutti Enders, Felicitas, Lim, Johan, Mertens, Jorre S., van den Hoogen, Luuk L., Wijngaarde, Camiel A., Yeo, Joo Guan, Meyer, Alain, Otten, Henny G., Fritsch-Stork, Ruth D.E., Kamphuis, Sylvia S.M., Hoppenreijs, Esther P.A.H., Armbrust, Wineke, van den Berg, J. Merlijn, Hissink Muller, Petra C.E., Tekstra, Janneke, Hoogendijk, Jessica E., Deakin, Claire T., de Jager, Wilco, van Roon, Joël A.G., van der Pol, W. Ludo, Nistala, Kiran, Pilkington, Clarissa, de Visser, Marianne, Arkachaisri, Thaschawee, Radstake, Timothy R.D.J., van der Kooi, Anneke J., Nierkens, Stefan, Wedderburn, Lucy R., van Royen-Kerkhof, Annet, van Wijk, Femke, UMC Utrecht, CTI Van Wijk, Translationele immunologie, Infection & Immunity, Opleiding Neurologie, Brain, CDL Patiëntenzorg MI, CDL Celdiagnostiek, MS Reumatologie/Immunologie/Infectie, ZL Neuromusculaire Ziekten Medisch, CTI, CTI Radstake, CTI Research, CTI Nierkens, CTI UDAIR, Immuno/reuma patientenzorg, Child Health, Immuno/reuma onderzoek 4, Wienke, Judith, Bellutti Enders, Felicitas, Lim, Johan, Mertens, Jorre S., van den Hoogen, Luuk L., Wijngaarde, Camiel A., Yeo, Joo Guan, Meyer, Alain, Otten, Henny G., Fritsch-Stork, Ruth D.E., Kamphuis, Sylvia S.M., Hoppenreijs, Esther P.A.H., Armbrust, Wineke, van den Berg, J. Merlijn, Hissink Muller, Petra C.E., Tekstra, Janneke, Hoogendijk, Jessica E., Deakin, Claire T., de Jager, Wilco, van Roon, Joël A.G., van der Pol, W. Ludo, Nistala, Kiran, Pilkington, Clarissa, de Visser, Marianne, Arkachaisri, Thaschawee, Radstake, Timothy R.D.J., van der Kooi, Anneke J., Nierkens, Stefan, Wedderburn, Lucy R., van Royen-Kerkhof, Annet, and van Wijk, Femke

Published
2019

27. Muscle Biopsy Findings in Combination With Myositis‐Specific Autoantibodies Aid Prediction of Outcomes in Juvenile Dermatomyositis

Author

Deakin, Claire T., Yasin, Shireena A., Simou, Stefania, Arnold, Katie A., Tansley, Sarah L., Betteridge, Zoe E., McHugh, Neil J., Varsani, Hemlata, Holton, Janice L., Jacques, Thomas S., Pilkington, Clarissa A., Nistala, Kiran, Wedderburn, Lucy R., Armon, Kate, Ellis‐Gage, Joe, Roper, Holly, Briggs, Vanja, Watts, Joanna, McCann, Liza, Roberts, Ian, Baildam, Eileen, Hanna, Louise, Lloyd, Olivia, Wadeson, Susan, Riley, Phil, McGovern, Ann, Ryder, Clive, Scott, Janis, Thomas, Beverley, Southwood, Taunton, Al‐Abadi, Eslam, Wyatt, Sue, Jackson, Gillian, Amin, Tania, Wood, Mark, VanRooyen, Vanessa, Burton, Deborah, Davidson, Joyce, Gardner‐Medwin, Janet, Martin, Neil, Ferguson, Sue, Waxman, Liz, Browne, Michael, Friswell, Mark, Swift, Alison, Jandial, Sharmila, Stevenson, Vicky, Wade, Debbie, Sen, Ethan, Smith, Eve, Qiao, Lisa, Watson, Stuart, Duong, Claire, Venning, Helen, Satyapal, Rangaraj, Stretton, Elizabeth, Jordan, Mary, Mosley, Ellen, Frost, Anna, Crate, Lindsay, Warrier, Kishore, Stafford, Stefanie, Hasson, Nathan, Maillard, Sue, Halkon, Elizabeth, Brown, Virginia, Juggins, Audrey, Smith, Sally, Lunt, Sian, Enayat, Elli, Kassoumeri, Laura, Beard, Laura, Glackin, Yvonne, Almeida, Beverley, Marques, Raquel, Dowle, Stefanie, Papadopoulou, Charis, Murray, Kevin, Ioannou, John, Suffield, Linda, Al‐Obaidi, Muthana, Lee, Helen, Leach, Sam, Smith, Helen, McMahon, Anne‐Marie, Chisem, Heather, Kingshott, Ruth, Wilkinson, Nick, Inness, Emma, Kendall, Eunice, Mayers, David, Etherton, Ruth, Bailey, Kathryn, Clinch, Jacqui, Fineman, Natalie, Pluess‐Hall, Helen, Vallance, Lindsay, Akeroyd, Louise, Leahy, Alice, Collier, Amy, Cutts, Rebecca, De Graaf, Hans, Davidson, Brian, Hartfree, Sarah, and Pratt, Danny

Subjects
Male, Interferon-Induced Helicase, IFIH1, Severity of Illness Index, Dermatomyositis, Quadriceps Muscle, Cohort Studies, Adrenal Cortex Hormones, Risk Factors, Odds Ratio, Threonine-tRNA Ligase, Humans, Longitudinal Studies, Child, Muscle, Skeletal, Autoantibodies, Myositis, Protective Factors, Prognosis, Pediatric Rheumatology, United Kingdom, DNA-Binding Proteins, Methotrexate, Child, Preschool, Female, Signal Recognition Particle, DNA Topoisomerases, Immunosuppressive Agents, Transcription Factors
Abstract

Objective Juvenile dermatomyositis (DM) is a rare and severe autoimmune condition characterized by rash and proximal muscle weakness. While some patients respond to standard treatment, others do not. This study was carried out to investigate whether histopathologic findings and myositis‐specific autoantibodies (MSAs) have prognostic significance in juvenile DM. Methods Muscle biopsy samples (n = 101) from patients in the UK Juvenile Dermatomyositis Cohort and Biomarker Study were stained, analyzed, and scored for severity of histopathologic features. In addition, autoantibodies were measured in the serum or plasma of patients (n = 90) and longitudinal clinical data were collected (median duration of follow‐up 4.9 years). Long‐term treatment status (on or off medication over time) was modeled using generalized estimating equations. Results Muscle biopsy scores differed according to MSA subgroup. When the effects of MSA subgroup were accounted for, increased severity of muscle histopathologic features was predictive of an increased risk of remaining on treatment over time: for the global pathology score (histopathologist's visual analog scale [hVAS] score), 1.48‐fold higher odds (95% confidence interval [95% CI] 1.12–1.96; P = 0.0058), and for the total biopsy score (determined with the standardized score tool), 1.10‐fold higher odds (95% CI 1.01–1.21; P = 0.038). A protective effect was identified in patients with anti–Mi‐2 autoantibodies, in whom the odds of remaining on treatment were 7.06‐fold lower (95% CI 1.41–35.36; P = 0.018) despite muscle biopsy scores indicating more severe disease. In patients with anti–nuclear matrix protein 2 autoantibodies, anti–transcription intermediary factor 1γ autoantibodies, or no detectable autoantibody, increased histopathologic severity alone, without adjustment for the effect of MSA subtype, was predictive of the risk of remaining on treatment: for the hVAS global pathology score, 1.61‐fold higher odds (95% CI 1.16–2.22; P = 0.004), and for the total biopsy score, 1.13‐fold higher odds (95% CI 1.03–1.24; P = 0.013). Conclusion Histopathologic severity, in combination with MSA subtype, is predictive of the risk of remaining on treatment in patients with juvenile DM and may be useful for discussing probable treatment length with parents and patients. Understanding these associations may identify patients at greater risk of severe disease.

Published
2016

28. Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

Author

Piper, Christopher J.M., primary, Rosser, Elizabeth C., additional, Oleinika, Kristine, additional, Nistala, Kiran, additional, Krausgruber, Thomas, additional, Rendeiro, André F., additional, Banos, Aggelos, additional, Drozdov, Ignat, additional, Villa, Matteo, additional, Thomson, Scott, additional, Xanthou, Georgina, additional, Bock, Christoph, additional, Stockinger, Brigitta, additional, and Mauri, Claudia, additional

Published
2019
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29. Galectin‐9 and CXCL10 as Biomarkers for Disease Activity in Juvenile Dermatomyositis: A Longitudinal Cohort Study and Multicohort Validation

Author

Wienke, Judith, primary, Bellutti Enders, Felicitas, additional, Lim, Johan, additional, Mertens, Jorre S., additional, Hoogen, Luuk L., additional, Wijngaarde, Camiel A., additional, Yeo, Joo Guan, additional, Meyer, Alain, additional, Otten, Henny G., additional, Fritsch‐Stork, Ruth D. E., additional, Kamphuis, Sylvia S. M., additional, Hoppenreijs, Esther P. A. H., additional, Armbrust, Wineke, additional, Berg, J. Merlijn, additional, Hissink Muller, Petra C. E., additional, Tekstra, Janneke, additional, Hoogendijk, Jessica E., additional, Deakin, Claire T., additional, Jager, Wilco, additional, Roon, Joël A. G., additional, Pol, W. Ludo, additional, Nistala, Kiran, additional, Pilkington, Clarissa, additional, Visser, Marianne, additional, Arkachaisri, Thaschawee, additional, Radstake, Timothy R. D. J., additional, Kooi, Anneke J., additional, Nierkens, Stefan, additional, Wedderburn, Lucy R., additional, Royen‐Kerkhof, Annet, additional, and Wijk, Femke, additional

Published
2019
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30. Development and validation of a composite disease activity score for measurement of muscle and skin involvement in juvenile dermatomyositis

Author

Rosina, Silvia, primary, Consolaro, Alessandro, additional, van Dijkhuizen, Pieter, additional, Pistorio, Angela, additional, Varnier, Giulia Camilla, additional, Bovis, Francesca, additional, Nistala, Kiran, additional, Maillard, Susan, additional, Civino, Adele, additional, Tsitsami, Elena, additional, de Inocencio, Jaime, additional, Jelusic, Marija, additional, Vojinovic, Jelena, additional, Espada, Graciela, additional, Makay, Balahan, additional, Katsicas, Maria Martha, additional, Pratsidou-Gertsi, Polixeni, additional, Lazarevic, Dragana, additional, Rao, Anand Prahalad, additional, Pires Marafon, Denise, additional, Martini, Alberto, additional, Pilkington, Clarissa, additional, Ruperto, Nicolino, additional, and Ravelli, Angelo, additional

Published
2019
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32. Effective induction therapy for anti-SRP associated myositis in childhood:A small case series and review of the literature

Author

Binns, E L, Moraitis, Elena, Maillard, S, Tansley, S, McHugh, N, Jacques, Thomas S, Wedderburn, L R, Pilkington, Clarissa, Yasin, S A, and Nistala, Kiran

Subjects
Journal Article
Abstract

BACKGROUND: Anti-Signal Recognition Particle associated myopathy is a clinically and histopathologically distinct subgroup of Juvenile Idiopathic Inflammatory Myositis, which is under-recognised in children and fails to respond to conventional first line therapies. We present three cases where remission was successfully induced using combination therapy with intensive rehabilitation.CASE PRESENTATIONS: Three new patients are reported. All 3 cases presented with profound, rapid-onset, proximal myopathy and markedly raised CK, but no rash. Histology revealed a destructive myopathy characterized by scattered atrophic and necrotic fibres with little or no inflammatory infiltrate. All 3 patients responded to induction with cyclophosphamide, IVIG and rituximab, in conjunction with intensive physiotherapy and methotrexate as the maintenance agent. Our patients regained near-normal strength (MMT > 70/80), in contrast with the current literature where >50% of cases reported severe residual weakness. A literature search on paediatric anti-SRP myositis was performed to June 2016; PubMed was screened using a combination of the following terms: signal recognition particle, autoantibodies, antibodies, myositis, muscular diseases, skeletal muscle, childhood, paediatric, juvenile. Articles in a foreign language were excluded. Nine case studies were found.CONCLUSION: This paper supports the hypothesis that anti-SRP myositis is distinct from other JIIM. It is an important differential to JDM and should be considered where there is severe weakness without rash or if highly elevated muscle enzymes (CK > 10,000 U/l) are found. Early identification is essential to initiate aggressive medical and physical therapy. Greater international collaboration and long-term follow-up data is needed to establish the most effective treatment strategy for this rare group of patients.

Published
2017
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33. CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α

Author

Piper, Christopher J. M., primary, Wilkinson, Meredyth G. Ll., additional, Deakin, Claire T., additional, Otto, Georg W., additional, Dowle, Stefanie, additional, Duurland, Chantal L., additional, Adams, Stuart, additional, Marasco, Emiliano, additional, Rosser, Elizabeth C., additional, Radziszewska, Anna, additional, Carsetti, Rita, additional, Ioannou, Yiannis, additional, Beales, Philip L., additional, Kelberman, Daniel, additional, Isenberg, David A., additional, Mauri, Claudia, additional, Nistala, Kiran, additional, and Wedderburn, Lucy R., additional

Published
2018
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34. Consensus-based recommendations for the management of juvenile dermatomyositis

Author

Bellutti Enders, Felicitas, Bader-Meunier, Brigitte, Baildam, Eileen, Constantin, Tamas, Dolezalova, Pavla, Feldman, Brian M., Lahdenne, Pekka, Magnusson, Bo, Nistala, Kiran, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Russo, Ricardo, Uziel, Yosef, van Brussel, Marco, van der Net, Janjaap, Vastert, Sebastiaan, Wedderburn, Lucy R., Wulffraat, Nicolaas, McCann, Liza J., van Royen-Kerkhof, Annet, Bellutti Enders, Felicitas, Bader-Meunier, Brigitte, Baildam, Eileen, Constantin, Tamas, Dolezalova, Pavla, Feldman, Brian M., Lahdenne, Pekka, Magnusson, Bo, Nistala, Kiran, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Russo, Ricardo, Uziel, Yosef, van Brussel, Marco, van der Net, Janjaap, Vastert, Sebastiaan, Wedderburn, Lucy R., Wulffraat, Nicolaas, McCann, Liza J., and van Royen-Kerkhof, Annet

Published
2017

35. Consensus-based recommendations for the management of juvenile dermatomyositis

Author

University of Helsinki, Hospital for Children and Adolescents, Enders, Felicitas Bellutti, Bader-Meunier, Brigitte, Baildam, Eileen, Constantin, Tamas, Dolezalova, Pavia, Feldman, Brian M., Lahdenne, Pekka, Magnusson, Bo, Nistala, Kiran, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Russo, Ricardo, Uziel, Yosef, van Brussel, Marco, van der Net, Janjaap, Vastert, Sebastiaan, Wedderburn, Lucy R., Wulffraat, Nicolaas, McCann, Liza J., van Royen-Kerkhof, Annet, University of Helsinki, Hospital for Children and Adolescents, Enders, Felicitas Bellutti, Bader-Meunier, Brigitte, Baildam, Eileen, Constantin, Tamas, Dolezalova, Pavia, Feldman, Brian M., Lahdenne, Pekka, Magnusson, Bo, Nistala, Kiran, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Russo, Ricardo, Uziel, Yosef, van Brussel, Marco, van der Net, Janjaap, Vastert, Sebastiaan, Wedderburn, Lucy R., Wulffraat, Nicolaas, McCann, Liza J., and van Royen-Kerkhof, Annet

Abstract

Background In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile dermatomyositis (JDM) is a rare disease within the group of paediatric rheumatic diseases (PRDs) and can lead to significant morbidity. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. Consequently, treatment regimens differ throughout Europe. Objectives To provide recommendations for diagnosis and treatment of JDM. Methods Recommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was constituted, consisting of 19 experienced paediatric rheumatologists and 2 experts in paediatric exercise physiology and physical therapy, mainly from Europe. Recommendations derived from a validated systematic literature review were evaluated by an online survey and subsequently discussed at two consensus meetings using nominal group technique. Recommendations were accepted if > 80% agreement was reached. Results In total, 7 overarching principles, 33 recommendations on diagnosis and 19 recommendations on therapy were accepted with > 80% agreement among experts. Topics covered include assessment of skin, muscle and major organ involvement and suggested treatment pathways. Conclusions The SHARE initiative aims to identify best practices for treatment of patients suffering from PRD. Within this remit, recommendations for the diagnosis and treatment of JDM have been formulated by an evidenceinformed consensus process to produce a standard of care for patients with JDM throughout Europe.

Published
2017

36. Consensus-based recommendations for the management of juvenile dermatomyositis

Author

CTI Vastert, Kinderbewegingszorg patientenzorg, Child Health, Cluster Ontwikkelingsgerichte zorg, Reumatologie patientenzorg, Infection & Immunity, Cluster B, Regenerative Medicine and Stem Cells, Reumatologie, Bellutti Enders, Felicitas, Bader-Meunier, Brigitte, Baildam, Eileen, Constantin, Tamas, Dolezalova, Pavla, Feldman, Brian M., Lahdenne, Pekka, Magnusson, Bo, Nistala, Kiran, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Russo, Ricardo, Uziel, Yosef, van Brussel, Marco, van der Net, Janjaap, Vastert, Sebastiaan, Wedderburn, Lucy R., Wulffraat, Nicolaas, McCann, Liza J., van Royen-Kerkhof, Annet, CTI Vastert, Kinderbewegingszorg patientenzorg, Child Health, Cluster Ontwikkelingsgerichte zorg, Reumatologie patientenzorg, Infection & Immunity, Cluster B, Regenerative Medicine and Stem Cells, Reumatologie, Bellutti Enders, Felicitas, Bader-Meunier, Brigitte, Baildam, Eileen, Constantin, Tamas, Dolezalova, Pavla, Feldman, Brian M., Lahdenne, Pekka, Magnusson, Bo, Nistala, Kiran, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Russo, Ricardo, Uziel, Yosef, van Brussel, Marco, van der Net, Janjaap, Vastert, Sebastiaan, Wedderburn, Lucy R., Wulffraat, Nicolaas, McCann, Liza J., and van Royen-Kerkhof, Annet

Published
2017

37. Muscle biopsy in combination with myositis-specific autoantibodies aids prediction of outcomes in juvenile dermatomyositis

Author

Deakin, Claire T., Yasin, Shireena A., Simou, Stefania, Arnold, Katie A., Tansley, Sarah L., Betteridge, Zoe E., McHugh, Neil J., Varsani, Hemlata, Holton, Janice L., Jacques, Thomas S., Pilkington, Clarissa A., Nistala, Kiran, and Wedderburn, Lucy R.

Subjects
SDG 3 - Good Health and Well-being
Abstract

ObjectiveJuvenile dermatomyositis (DM) is a rare and severe autoimmune condition characterized by rash and proximal muscle weakness. While some patients respond to standard treatment, others do not. This study was carried out to investigate whether histopathologic findings and myositis‐specific autoantibodies (MSAs) have prognostic significance in juvenile DM.MethodsMuscle biopsy samples (n = 101) from patients in the UK Juvenile Dermatomyositis Cohort and Biomarker Study were stained, analyzed, and scored for severity of histopathologic features. In addition, autoantibodies were measured in the serum or plasma of patients (n = 90) and longitudinal clinical data were collected (median duration of follow‐up 4.9 years). Long‐term treatment status (on or off medication over time) was modeled using generalized estimating equations.ResultsMuscle biopsy scores differed according to MSA subgroup. When the effects of MSA subgroup were accounted for, increased severity of muscle histopathologic features was predictive of an increased risk of remaining on treatment over time: for the global pathology score (histopathologist's visual analog scale [hVAS] score), 1.48‐fold higher odds (95% confidence interval [95% CI] 1.12–1.96; P = 0.0058), and for the total biopsy score (determined with the standardized score tool), 1.10‐fold higher odds (95% CI 1.01–1.21; P = 0.038). A protective effect was identified in patients with anti–Mi‐2 autoantibodies, in whom the odds of remaining on treatment were 7.06‐fold lower (95% CI 1.41–35.36; P = 0.018) despite muscle biopsy scores indicating more severe disease. In patients with anti–nuclear matrix protein 2 autoantibodies, anti–transcription intermediary factor 1γ autoantibodies, or no detectable autoantibody, increased histopathologic severity alone, without adjustment for the effect of MSA subtype, was predictive of the risk of remaining on treatment: for the hVAS global pathology score, 1.61‐fold higher odds (95% CI 1.16–2.22; P = 0.004), and for the total biopsy score, 1.13‐fold higher odds (95% CI 1.03–1.24; P = 0.013).ConclusionHistopathologic severity, in combination with MSA subtype, is predictive of the risk of remaining on treatment in patients with juvenile DM and may be useful for discussing probable treatment length with parents and patients. Understanding these associations may identify patients at greater risk of severe disease.

Published
2016
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38. Interleukin-35 takes the 'B' line

Author

Mauri, Claudia and Nistala, Kiran

Subjects
Autoimmunity -- Development and progression -- Genetic aspects -- Research, B cells -- Physiological aspects -- Genetic aspects -- Research, Interleukins -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Regulatory B cells exert an immunosuppressive role by secreting the cytokine interleukin-10 (IL-10). Two studies have now identified B cell-derived IL-35 as both an inducer and a mediator of regulatory B cell function. IL-35 switched off inflammation in mouse models of autoimmunity, whereas its absence in B cells in mice enhanced survival after Salmonella enterica serovar Typhimurium infection. IL-35 could therefore be targeted for treating human autoimmune and infectious disease., There is an established role for B cells in the maintenance of host defense; however, it is now clear that B cells can also suppress immune reactions and therefore act [...]

Published
2014

40. Consensus-based recommendations for the management of juvenile dermatomyositis

Author

Bellutti Enders, Felicitas, primary, Bader-Meunier, Brigitte, additional, Baildam, Eileen, additional, Constantin, Tamas, additional, Dolezalova, Pavla, additional, Feldman, Brian M, additional, Lahdenne, Pekka, additional, Magnusson, Bo, additional, Nistala, Kiran, additional, Ozen, Seza, additional, Pilkington, Clarissa, additional, Ravelli, Angelo, additional, Russo, Ricardo, additional, Uziel, Yosef, additional, van Brussel, Marco, additional, van der Net, Janjaap, additional, Vastert, Sebastiaan, additional, Wedderburn, Lucy R, additional, Wulffraat, Nicolaas, additional, McCann, Liza J, additional, and van Royen-Kerkhof, Annet, additional

Published
2016
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41. Colaboradores

Author

Abramson, Steven, An, KaiNan, Andrade, Felipe, Ardoin, Stacy P., Barton, Anne, Baughman, Robert P., Beaton, Dorcas E., Beere, Helen M., Beltran, Javier, Bending, David, Bennett, Robert M., Bermas, Bonnie L., Bertsias, George, Bhardwaj, Nina, Bijlsma, Johannes W.J., Bockenstedt, Linda K., Boers, Maarten, Boilard, Eric, Boin, Francesco, Boumpas, Dimitrios T., Boyle, David L., Bradley, Sean, Brown, Matthew, Buch, Maya, Buckley, Christopher D., Budd, Ralph C., Burg, Nathalie, Burns, Christopher M., Cannella, Amy C., Carter, John D., Chakravarty, Eliza F., Chakravarty, Soumya D., Chang, Christopher, Cheng, Joseph S., Chiodo, Christopher P., Chung, Sharon, Cleland, Leslie G., Cohen, Stanley, Colbert, Robert A., Cook, Paul P., Craft, Joseph E., Crofford, Leslie J., Cronstein, Bruce N., Crow, Mary K., Crowson, Cynthia S., Culley, Kirsty L., Cunnane, Gaye, Dall’Era, Maria, Darrah, Erika, Davis, John M., III, De Bari, Cosimo, Dell’Accio, Francesco, Diamond, Betty, Di Cesare, Paul E., Dixit, Rajiv, Drenth, Joost P.H., Dustin, Michael L., El-Gabalawy, Hani S., Elmamoun, Musaab, Erickson, Alan R., Erkan, Doruk, Eyre, Stephen, Fanouriakis, Antonis, Felson, David T., Field, Max, Filer, Andrew, Firestein, Gary S., Fishman, Felicity G., FitzGerald, Oliver, Flaherty, John P., Nieves, César E. Fors, Fortner, Karen A., Gabriel, Sherine E., Gasque, Philippe, Gershwin, M. Eric, Gladue, Heather S., Goldring, Mary B., Goldring, Steven R., Golightly, Yvonne M., Goodman, Stuart, Gordon, Siamon, Grassi, Walter, Green, Douglas R., Greenspan, Adam, Gregersen, Peter, Grimaldi, Christine, Guilherme, Luiza, Hajj-Ali, Rula A., Haudenschild, Dominik R., Hellmann, David B., Holmdahl, Rikard, Hsu, Joyce J., Huddleston, James I., III, Hudson, Alan P., Huizinga, Thomas W.J., Hunder, Gene G., Iversen, Maura D., Jacobs, Johannes W.G., Jen, Ho, Jordan, Joanne M., Jorizzo, Joseph L., Kalil, Jorge, Kaufman, Kenton, Kaufman, William S., Kavanaugh, Arthur, Keenan, Robert T., Kenna, Tony, Kerr, Darcy A., Koch, Alisa E., Kono, Dwight H., Korsten, Peter, Krakow, Deborah, Krasnokutsky, Svetlana, Lafeber, Floris P.J.G., Lambert, Robert G.W., Lane, Nancy E., Langford, Carol A., Laskin, Daniel M., Layh-Schmitt, Gerlinde, Lee, Lela A., Lee, Tzielan C., Lockshin, Michael D., Lozada, Carlos J., Lundberg, Ingrid E., Luqmani, Raashid, Luyten, Frank P., Mader, Reuven, Maksymowych, Walter, Markenson, Joseph A., Martin, Scott David, Matteson, Eric L., McGregor, Laura, McInnes, Iain B., McNamara, Elizabeth K., Mikuls, Ted R., Miller, Mark S., Ming, Pedro Azevedo, Moder, Kevin G., Monach, Paul A., Moulton, Vaishali R., Nagaraju, Kanneboyina, Nelson, Amanda E., Nigrovic, Peter A., Nistala, Kiran, O’Dell, James R., Okada, Yasunori, Østergaard, Mikkel, Otero, Miguel, Palmer, Bradley M., Panush, Richard S., Peng, Stanford L., Pillai, Shiv, Pillinger, Michael H., Plüddemann, Annette, Polston, Gregory R., Porcelli, Steven A., Price, Mark D., Reed, Ann M., Reveille, John D., Robinson, Angela B., Robinson, Philip, Robinson, William H., Roosendaal, Goris, Rosen, Antony, Rosenbaum, James T., Rosenberg, Andrew E., Ruderman, Eric M., Saag, Kenneth G., Salmon, Jane E., Sammaritano, Lisa R., Samuels, Jonathan, Sandborg, Christy I., Sawalha, Amr H., Saxena, Amit, Schett, Georg, Schutgens, Roger E.G., Seldin, David C., Shah, Binita, Sikora, Keith A., Simon, Anna, Siraj, Dawd S., Sorkin, Linda S., Clair, E. William St., Stamp, Lisa K., Stone, John H., Suarez-Fueyo, Abel, Svensson, Camilla I., Sweiss, Nadera J., Swigart, Carrie R., Szekanecz, Zoltán, Tait, Stephen, Tanne, Antoine, Taylor, Peter C., Terkeltaub, Robert, Theofilopoulos, Argyrios N., Thornhill, Thomas S., Torok, Kathryn S., Toth, Michael J., Tozman, Elaine C., Trouw, Leendert A., Tsokos, George C., Tugwell, Peter, Tutuncu, Zuhre, Upadhyaya, Shivam, Van Der Helm-Van Mil, Annette H.M., van der Linden, Sjef, Van Der Meer, Jos W.M., Van Laar, Jacob M., Van Meter, Heather, van Vollenhoven, Ronald F., van Vulpen, Lize F.D., Varga, John, Vaseer, Samera, Vasquez-Castellanos, Raul, Veale, Douglas J., Wakefield, Richard J., Wallace, Mark S., Wang, Ruoning, Wang, Tingting, Warshaw, David M., Wedderburn, Lucy R., Werth, Victoria P., Wigley, Fredrick M., Wofsy, David, Wollheim, Frank A., Wondimu, Elisabeth, Wong, Cyrus, Wortmann, Robert L., Yelin, Edward, Zayat, Ahmed, Zou, Yong-Rui, and Zurier, Robert B.

Published
2018
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42. CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α.

Author

Piper, Christopher J. M., Wilkinson, Meredyth G. Ll., Deakin, Claire T., Otto, Georg W., Dowle, Stefanie, Duurland, Chantal L., Adams, Stuart, Marasco, Emiliano, Rosser, Elizabeth C., Radziszewska, Anna, Carsetti, Rita, Ioannou, Yiannis, Beales, Philip L., Kelberman, Daniel, Isenberg, David A., Mauri, Claudia, Nistala, Kiran, and Wedderburn, Lucy R.

Subjects
B cells, DERMATOMYOSITIS
Abstract

Juvenile dermatomyositis (JDM) is a rare form of childhood autoimmune myositis that presents with proximal muscle weakness and skin rash. B cells are strongly implicated in the pathogenesis of the disease, but the underlying mechanisms are unknown. Therefore, the main objective of our study was to investigate mechanisms driving B cell lymphocytosis and define pathological features of B cells in JDM patients. Patients were recruited through the UK JDM Cohort and Biomarker study. Peripheral blood B cell subpopulations were immunophenotyped by flow cytometry. The results identified that immature transitional B cells were significantly expanded in active JDM, actively dividing, and correlated positively with disease activity. Protein and RNAseq analysis revealed high interferon alpha (IFNα) and TLR7-pathway signatures pre-treatment. Stimulation of B cells through TLR7/8 promoted both IL-10 and IL-6 production in controls but failed to induce IL-10 in JDM patient cells. Interrogation of the CD40-CD40L pathway (known to induce B cell IL-10 and IL-6) revealed similar expression of IL-10 and IL-6 in B cells cultured with CD40L from both JDM patients and controls. In conclusion, JDM patients with active disease have a significantly expanded immature transitional B cell population which correlated with the type I IFN signature. Activation through TLR7 and IFNa may drive the expansion of immature transitional B cells in JDM and skew the cells toward a pro-inflammatory phenotype. [ABSTRACT FROM AUTHOR]

Published
2018
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45. Comparison of the Utility and Validity of Three Scoring Tools to Measure Skin Involvement in Patients With Juvenile Dermatomyositis

Author

Campanilho‐Marques, Raquel, Almeida, Beverley, Deakin, Claire, Arnold, Katie, Gallot, Natacha, de Iorio, Maria, Nistala, Kiran, Pilkington, Clarissa A., Wedderburn, Lucy R., Armon, Kate, Ellis‐Gage, Joe, Roper, Holly, Briggs, Vanja, Watts, Joanna, McCann, Liza, Roberts, Ian, Baildam, Eileen, Hanna, Louise, Lloyd, Olivia, Riley, Phil, McGovern, Ann, Ryder, Clive, Scott, Janis, Thomas, Beverley, Southwood, Taunton, Al‐Abadi, Eslam, Wyatt, Sue, Jackson, Gillian, Amin, Tania, Wood, Mark, VanRooyen, Vanessa, Burton, Deborah, Davidson, Joyce, Gardner‐Medwin, Janet, Martin, Neil, Ferguson, Sue, Waxman, Liz, Browne, Michael, Friswell, Mark, Foster, Helen, Swift, Alison, Jandial, Sharmila, Stevenson, Vicky, Wade, Debbie, Sen, Ethan, Smith, Eve, Qiao, Lisa, Watson, Stuart, Venning, Helen, Satyapal, Rangaraj, Stretton, Elizabeth, Jordan, Mary, Mosley, Ellen, Frost, Anna, Crate, Lindsay, Warrier, Kishore, Wedderburn, Lucy, Pilkington, Clarissa, Hasson, Nathan, Nistala, Kiran, Maillard, Sue, Halkon, Elizabeth, Brown, Virginia, Juggins, Audrey, Smith, Sally, Lunt, Sian, Enayat, Elli, Varsani, Hemlata, Kassoumeri, Laura, Beard, Laura, Arnold, Katie, Glackin, Yvonne, Simou, Stephanie, Campanilho‐Marques, Raquel, Almeida, Beverley, Murray, Kevin, Ioannou, John, Suffield, Linda, Al‐Obaidi, Muthana, Lee, Helen, Leach, Sam, Smith, Helen, Wilkinson, Nick, Inness, Emma, Kendall, Eunice, Mayers, David, Clinch, Jacqui, and Pluess‐Hall, Helen

Abstract

To compare the abbreviated Cutaneous Assessment Tool (CAT), Disease Activity Score (DAS), and Myositis Intention to Treat Activity Index (MITAX) and correlate them with the physician's 10‐cm skin visual analog scale (VAS) in order to define which tool best assesses skin disease in patients with juvenile dermatomyositis. A total of 71 patients recruited to the UK Juvenile Dermatomyositis Cohort and Biomarker Study were included and assessed for skin disease using the CAT, DAS, MITAX, and skin VAS. The Childhood Myositis Assessment Scale (CMAS), manual muscle testing of 8 groups (MMT8), muscle enzymes, inflammatory markers, and physician's global VAS were recorded. Relationships were evaluated using Spearman's correlations and predictors with linear regression. Interrater reliability was assessed using intraclass correlation coefficients. All 3 tools showed correlation with the physician's global VAS and skin VAS, with DAS skin showing the strongest correlation with skin VAS. DAS skin and CAT activity were inversely correlated with CMAS and MMT8, but these correlations were moderate. No correlations were found between the skin tools and inflammatory markers or muscle enzymes. DAS skin and CAT were the quickest to complete (mean ± SD 0.68 ± 0.1 minutes and 0.63 ± 0.1 minutes, respectively). The 3 skin tools were quick and easy to use. The DAS skin correlated best with the skin VAS. The addition of CAT in a bivariate model containing the physician's global VAS was a statistically significant estimator of skin VAS score. We propose that there is scope for a new skin tool to be devised and tested, which takes into account the strengths of the 3 existing tools.

Published
2016
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46. SHARE – workpackage 5: evidence based recommendations for diagnosis and treatment of juvenile dermatomyositis

Author

Enders, Felicitas Bellutti, primary, Bader-Meunier, Brigitte, additional, Baildam, Eileen, additional, Constantin, Tamas, additional, Dolezalova, Pavla, additional, Feldman, Brian, additional, Lahdenne, Pekka, additional, Magnusson, Bo, additional, Nistala, Kiran, additional, Pilkington, Clarissa, additional, Ravelli, Angelo, additional, Russo, Ricardo, additional, van Brussel, Marco, additional, van der Net, JanJaap, additional, Wedderburn, Lucy, additional, Vastert, Bas, additional, Wulffraat, Nico, additional, McCann, Liza, additional, and van Royen-Kerkhof, Annet, additional

Published
2014
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