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Background Acute ischemic stroke (AIS) is a serious cerebrovascular disease, which causes a heavy burden on society and patients. Ligustrazine injection has been widely used in the treatment of AIS with significant efficacy, but there is still a lack of direct or indirect comparison between ligustrazine injections. Objective To systematically evaluate the efficacy and safety of ligustrazine injection in the adjuvant treatment of AIS within 72 hours. Methods CNKI, Wanfang Data Knowledge Service Platform, VIP, PubMed, Cochrane Library, Embase, and Web of Science databases were searched for randomized controlled trials (RCTs) about the efficacy and safety of ligustrazine injection in the treatment of AIS from inception to April 2023. Literature was independently screened, extracted and quality assessed by 2 investigators using the Cochrane Evaluation Tool. RevMan 5.3, Stata 17, Addis and RStudio software were used to statistically compare and rank the efficacy and safety of different types of ligustrazine injection. Results A total of 71 papers involving 7 304 cases were included, and the interventions included Salvia Miltiorrhiza Ligustrazine Injection (DSCXQ), Shenxiong Glucose Injection (SXPTT), Xingxiong Sodium Chloride Injection (XXLHN), Ligustrazine Phosphate Injection (LSCXQ) and Ligustrazine Hydrochloride Injection (YSCXQ) combined with conventional western medical therapy (CT), respectively, and CT alone. Direct Meta-analysis results showed that in improving all the outcome indicators of AIS, the total effective rate, NIHSS score, fibrinogen level, and incidence of adverse reactions of ligustrazine injection combined with CT were better than those of CT alone (PYSCXQ+CT (0.20) >LSCXQ+CT (0.15) >DSCXQ+CT (0.03) >XXLHN+CT (0.02) >CT (0) ; the order of cumulative probability in improving NIHSS score was SXPTT+CT (0.55) >XXLHN+CT (0.26) >YSCXQ+CT (0.12) >DSCXQ+CT (0.07) >CT (0) ; the order of cumulative probability in reducing fibrinogen level was XXLHN+CT (0.32) >LSCXQ+CT (0.22) >DSCXQ+CT (0.17) >SXPTT+CT (0.15) >YSCXQ+CT (0.14) >CT (0) ; the order of cumulative probability in safety was SXPTT+CT (0.79) >XXLHN+CT (0.13) >CT (0.04) >DSCXQ+CT (0.03) >YSCXQ+CT (0.01) . Conclusion Ligustrazine injection is effective and safe in adjuvant treatment of AIS, among which Shenxiong glucose injection was the best in total effective rate and improving NIHSS scores, with the least adverse reactions; Xingxiong sodium chloride injection has the most advantages in fibrinogen level.

Large forgings are crucial in aerospace applications; however, the residual stresses generated during their forming and heat treatment seriously affect their serviceability. Therefore, the non-destructive detection of residual stresses in large forgings is of far-reaching significance for ensuring the quality of forgings and realising precision machining. Although a variety of detection methods are available, there is still a lack of a programme that can comprehensively, accurately and non-destructively measure the residual stresses in large forgings. This study is dedicated to exploring the application of the bouncing impact indentation method in the non-destructive testing of residual stresses in large forgings. Through in-depth finite element simulations and orthogonal scheme analyses, we found that the elastic modulus, yield strength and work hardening indexes have significant effects on the impact indentation process. Further, we establish the dimensionless function of residual stress and indentation parameters, and successfully obtain the inversion algorithm of residual stress. The relative error of the calculated values of the indentation curves hm and hr in the simulation with reference values is not more than 3%, and the relative error of the corrected Pm inversion values for most virtual materials is not more than 5%. The folding elastic modulus and apparent elastic modulus obtained by inversion are controlled within 10%, which demonstrates a high value for engineering applications. In addition, we innovatively express the research results in the form of 3D stress diagrams, realising the digital expression of 3D residual stresses in large forgings based on feature point measurements and contour surface configurations, which provides intuitive and comprehensive data support for engineering practice. [ABSTRACT FROM AUTHOR]

To investigate the seroprevalence of Toxoplasma gondii infection in domestic cats in central China, 843 serum samples were collected in Henan province between March 2015 and May 2016 and tested for IgG antibodies against T. gondii using the enzyme-linked immunosorbent assay (ELISA). The overall seroprevalence of T. gondii was 21% (178/843). No significant difference was observed based on the sex of cats (p > 0.05). Significantly higher seroprevalence (p