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395 results on '"Niu, Lizhi"'

17. Pembrolizumab plus allogeneic NK cells in advanced non-small cell lung cancer patients

Author

Lin, Mao, Luo, Haihua, Liang, Shuzhen, Chen, Jibing, Liu, Aihua, Niu, Lizhi, and Jiang, Yong

Subjects
Apoptosis, Killer cells, Medical research, Pembrolizumab, Non-small cell lung cancer -- Development and progression -- Care and treatment, T cells, Small cell lung cancer, Biochemistry, Toxicity, Tumors, Cell death, Antibodies, Retirement benefits, Lung cancer, Health care industry
Abstract

BACKGROUND. The anti-programmed cell death 1 (anti-PD-1) antibody pembrolizumab is clinically active against nonsmall cell lung cancer (NSCLC). In addition to T cells, human natural killer (NK) cells, reported to have the potential to prolong the survival of patients with advanced NSCLC, also express PD-1. This study aimed to investigate the safety and efficacy of pembrolizumab plus allogeneic NK cells in patients with previously treated advanced NSCLC. METHODS. In total, 109 enrolled patients with a programmed death ligand 1 (PD-L1) tumor proportion score (TPS) of 1% or higher were randomly allocated to group A (n = 55 patients given pembrolizumab plus NK cells) or group B (n = 54 patients given pembrolizumab alone). The patients received i.v. pembrolizumab (10 mg/kg) once every 3 weeks and continued treatment until the occurrence of tumor progression or unacceptable toxicity. The patients in group A continuously received 2 cycles of NK cell therapy as 1 course of treatment. RESULTS. In our study, patients in group A had longer survival than did patients in group B (median overall survival [OS]: 15.5 months vs. 13.3 months; median progression-free survival [PFS]: 6.5 months vs. 4.3 months; P < 0.05). In group A patients with a TPS of 50% or higher, the median OS and PFS was significantly longer. Moreover, the patients in group A treated with multiple courses of NK cell infusion had better OS (18.5 months) than did those who received a single course of NK cell infusion (13.5 months). CONCLUSION. Pembrolizumab plus NK cell therapy yielded improved survival benefits in patients with previously treated [PD-L1.sup.+] advanced NSCLC. TRIAL REGISTRATION. ClinicalTrials.gov NCT02843204. FUNDING. This work was supported by grants from the National Natural Science Foundation of China (NSFC) - Guangdong Joint Foundation of China (no. U1601225); the NSFC (no. 81671965); the Guangdong Provincial Key Laboratory Construction Project of China (no. 2017B030314034); and the Key Scientific and Technological Program of Guangzhou City (no. 201607020016)., Introduction In the past few years, the incidence of lung cancer has increased at a rate of 7.5%, making it the most common malignancy and a serious danger to human [...]

Published
2020
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19. Clinical practice guidelines on image-guided thermal ablation of primary and metastatic lung tumors (2022 edition)

Author

Ye, Xin, Fan, Weijun, Wang, Zhongmin, Wang, Junjie, Wang, Hui, Niu, Lizhi, Fang, Yong, Gu, Shanzhi, Liu, Lingxiao, Liu, Baodong, Zhuang, Yiping, Wei, Zhigang, Li, Xiao, Li, Xiaoguang, Li, Yuliang, Li, Chunhai, Yang, Xia, Yang, Wuwei, Yang, Po, Lin, Zhengyu, Meng, Zhiqiang, Hu, Kaiwen, Liu, Chen, Huang, Yong, Huang, Guanghui, Huang, Kaiwen, Peng, Zhongmin, Han, Yue, Jin, Yong, Lei, Guangyan, Zhai, Bo, Li, Hailiang, Pan, Jie, Filippiadis, Dimitris, Kelekis, Alexis, Pua, Uei, Futacsi, Balazs, Yumchinserchin, N., Iezzi, Roberto, Tang, Alex, and Roy, Shuvro

Subjects
Metastasis -- Care and treatment, Practice guidelines (Medicine), Ablation (Surgery) -- Methods, Computer-assisted surgery -- Methods, Lung cancer -- Care and treatment, Health
Abstract

Byline: Xin. Ye, Weijun. Fan, Zhongmin. Wang, Junjie. Wang, Hui. Wang, Lizhi. Niu, Yong. Fang, Shanzhi. Gu, Lingxiao. Liu, Baodong. Liu, Yiping. Zhuang, Zhigang. Wei, Xiao. Li, Xiaoguang. Li, Yuliang. [...]

Published
2022

23. Expert consensus on thermal ablation therapy of pulmonary subsolid nodules (2021 Edition)

Author

Ye, Xin, Fan, Weijun, Wang, Zhongmin, Wang, Junjie, Wang, Hui, Wang, Jun, Wang, Chuntang, Niu, Lizhi, Fang, Yong, Gu, Shanzhi, Tian, Hui, Liu, Baodong, Liu, Lingxiao, Zhong, Lou, Zhuang, Yiping, Chi, Jiachang, Sun, Xichao, Yang, Nuo, Wei, Zhigang, Li, Xiao, Li, Xiaoguang, Li, Yuliang, Li, Chunhai, Li, Yan, Yang, Xia, Yang, Wuwei, Yang, Po, Yang, Zhengqiang, Xiao, Yueyong, Song, Xiaoming, Zhang, Kaixian, Chen, Shilin, Chen, Weisheng, Lin, Zhengyu, Lin, Dianjie, Meng, Zhiqiang, Zhao, Xiaojing, Hu, Kaiwen, Liu, Chen, Liu, Cheng, Gu, Chundong, Xu, Dong, Huang, Yong, Huang, Guanghui, Peng, Zhongmin, Dong, Liang, Jiang, Lei, Han, Yue, Zeng, Qingshi, Jin, Yong, Lei, Guangyan, Zhai, Bo, Li, Hailiang, and Pan, Jie

Subjects
Lung tumors -- Care and treatment -- Diagnosis, Ablation (Surgery) -- Usage -- Standards -- Complications and side effects, Health
Abstract

Byline: Xin. Ye, Weijun. Fan, Zhongmin. Wang, Junjie. Wang, Hui. Wang, Jun. Wang, Chuntang. Wang, Lizhi. Niu, Yong. Fang, Shanzhi. Gu, Hui. Tian, Baodong. Liu, Lingxiao. Liu, Lou. Zhong, Yiping. [...]

Published
2021

24. Chinese expert consensus of image-guided irreversible electroporation for pancreatic cancer

Author

Wei, Yingtian, Xiao, Yueyong, Wang, Zhongmin, Hu, Xiaokun, Chen, Guang, Ding, Xiaoyi, Fan, Yong, Han, Yue, Huang, Kaiwen, Huang, Xuequan, Kuang, Ming, Lang, Xu, Li, Hailiang, Li, Chengli, Li, Jiakai, Li, Jiaping, Li, Maoquan, Lu, Yinying, Ni, Caifang, Niu, Lizhi, Sun, Junhui, Tian, Jinlin, Wang, Hao, Wang, Liwei, Wu, Peihong, Xie, Xiaoyan, Xing, Wenge, Xu, Linfeng, Yang, Po, Yu, Haipeng, Yuan, Chunwang, Zhai, Bo, Zhang, Yanfang, Zheng, Jiasheng, Zhou, Zhigang, Zhu, Xiaoli, Jiang, Tianan, and Zhang, Yingxun

Subjects
Electroporation -- Usage, Ablation (Surgery) -- Methods, Pancreatic cancer -- Care and treatment, Health
Abstract

Byline: Yingtian. Wei, Yueyong. Xiao, Zhongmin. Wang, Xiaokun. Hu, Guang. Chen, Xiaoyi. Ding, Yong. Fan, Yue. Han, Kaiwen. Huang, Xuequan. Huang, Ming. Kuang, Xu. Lang, Hailiang. Li, Chengli. Li, Jiakai. [...]

Published
2021

25. Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder

Author

Zeng Jianying, Qin Zilin, Zhou Liang, Fang Gang, Chen Jibing, Li Jialiang, Niu Lizhi, Liang Bing, and Xu Kecheng

Subjects
cryoablation, irreversible electroporation, liver, gallbladder, ablation, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The ablation of liver tumors located close to the gallbladder is likely to lead to complications. The aim of this article is to compare the safety and efficacy of irreversible electroporation (IRE) and cryoablation in rabbit livers at a location close to the gallbladder.

Published
2016
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