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15. Manejo de corpos em suspeitos ou confirmados COVID-19: um apoio aos municípios em caso de óbitos

Author

Rosa Pereira, Barbara Letícia, primary, CORADASSI, CARLOS EDUARDO, additional, DUARTE, C. R., additional, SILVA, C. S., additional, COMEL, D. D., additional, MÜLLER, E.V, additional, PINTO, E. B., additional, MANSANI, F. P., additional, FREITAS NETTO, F., additional, BENASSI, G., additional, PINTO, H. S., additional, SANTOS, J. F. L. P., additional, FLORIANO, Lara Simone Messias, additional, PREUSS, Lislei Teresinha, additional, NOGUEIRA, L. S., additional, SANTOS, M. C. A. O., additional, GASPAR, Maria Dagmar da Rocha, additional, Ribeiro de Souza, Mauriceia, additional, Alves dos Santos, Mateus, additional, BORGES, P.K.O, additional, and GOMES, Ricardo Zanetti, additional

Published
2021
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19. International incidence of childhood cancer, 2001–10: a population-based registry study

Author

Bouzbid, S, Hamdi-Cherif, M, Hablas, A, Chirpaz, E, Buziba, N, Chesumbai, GC, Manraj, SS, Reynders, D, Wabinga, HR, Chokunonga, E, Moreno, F, Lima, CA, Asturian Laporte, C, de Oliveira, JC, de Aquino, JA Pontes, Gallagher, SM Vargas, Uribe, CJ, Bravo, LE, Yepez Chamorro, MC, Torres Alvarado, G, Galán Alvarez, YH, Martinez Reyes, FC, Castillo Calvas, JC, Mendoza Alava, M, Cueva Ayala, P, Hanchard, B, Fajardo-Gutiérrez, A, Zavala Zegarra, DE, Barrios, E, Nikiforuk, C, Woods, R, Turner, D, MacIntyre, M, Corriveau, A, Navaneelan, T, Bertrand, C, Stuart-Panko, H, Wilson, RJ, Kosary, C, Shen, X, Brockhouse, J, Yee, GA, Mitchell, TC, Snipes, K, West, D, Rao, C, Bolick, S, Rycroft, RK, Mueller, L, Zheng, Y, Dosch, K, Brown, H, Vargas, A, Levin, GM, Bayakly, R, Johnson, C, Shen, T, Ruppert, L, Lynch, CF, Lai, SM, Tucker, TC, Wu, XC, Schwenn, M, Stern, K, Gershman, S, Copeland, G, Bushhouse, S, Rogers, DB, Jackson Thompson, J, Lemons, D, Frederick, S, Harris, JA, Riddle, B, Stroup, A, Wiggins, C, Schymura, MJ, Giljahn, LK, Sheikh, A, Schubert, S, Aldinger, W, Fulton, JP, Whiteside, M, Nogueira, L, Sweeney, C, Johnson, A, Martin, J, Farley, S, Harrelson, D, Malicki, R, Espinoza, JR, Hernandez, BY, Abulfateh, N, Wang, N, Ngan, RKC, Lingegowda, KB, Swaminathan, R, Koyande, SS, Silverman, B, Ozasa, K, Kanemura, S, Soda, M, Miyashiro, I, Shibata, A, Nimri, O, Won, YJ, Kim, CH, Hong, NS, Nam, HS, Kweon, S, Kim, WC, Huh, JS, Jung, KW, Yoo, CI, Elbasmy, A, Laudico, AV, Lumague, MR, AlMutlag, H, Buasom, R, Srisukho, S, Tanabodee, J, Wiangnon, S, Pongnikorn, D, Sriplung, H, Dirican, O, Eser, S, Le Hoang, M, Hackl, M, Zborovskaya, A, Dimitrova, N, Valerianova, Z, Sekerija, M, Pavlou, P, Dušek, M, Mägi, M, Clavel, J, Lacour, B, Guizard, AV, Bouvier, V, Troussard, X, Woronoff, AS, Tretarre, B, Colonna, M, Molinié, F, Bara, S, Velten, M, Marrer, E, Ganry, O, Grosclaude, P, Kaatsch, P, Zeissig, SR, Holleczek, B, Katalinic, A, Jakab, Z, Birgisson, H, Walsh, PM, Mangone, L, Merletti, F, Magoni, M, Ferretti, S, Serraino, D, Spagnoli, G, Fusco, M, Michiara, M, Tumino, R, Falcini, F, Sensi, F, Tisano, F, Piffer, S, Stracci, F, Tagliabue, G, Smailyte, G, Agius, D, Visser, O, Ursin, G, Didkowska, J, Trojanowski, M, Wojciechowska, U, Forjaz de Lacerda, G, Silva, MA, Laranja Pontes, J, da Costa Miranda, A, Kaiserova, E, Primic Žakelj, M, Peris-Bonet, R, Vicente Raneda, ML, Almar Marqués, E, Quirós Garcia, JR, Ramos Monserrat, M, Errezola Saizar, M, Alemán Herrera, A, Díaz García, JM, Marcos-Gragera, R, Sanchez-Perez, MJ, Ardanaz Aicua, E, Galceran, J, Klint, A, Kuehni, CE, Bouchardy, C, Levi, F, Bordoni, A, Konzelmann, I, Rohrmann, S, Stiller, CA, Gavin, AT, Brewster, DH, Phung, H, Rushton, S, Guthridge, S, Aitken, J, D'Onise, K, Venn, A, Farrugian, H, Threlfall, TJ, Laumond, S, Yen Kai Sun, L, Hendrix, J, Ballantine, K, Colombet, M, Dolya, A, Masuyer, E, Steliarova-Foucher, E, Steliarova-Foucher, Eva, Colombet, Murielle, Ries, Lynn A G, Moreno, Florencia, Dolya, Anastasia, Bray, Freddie, Hesseling, Peter, Shin, Hee Young, and Stiller, Charles A

Published
2017
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21. NOTAS INTRODUTÓRIAS SOBRE O LAZER NA REGIÃO DO CARIRI

Author

PESSOA, Amanda Raquel Rodrigues, primary, FLORO, E. F., additional, MOURA, M. M. M., additional, SANTOS, A. R., additional, GONÇALVES, A. M. A., additional, LIMA, A. C. L., additional, LIRA, B. G., additional, ARRAES, C. T., additional, FLÔR, C. R. B., additional, MOREIRA, F. A., additional, NUNES, J. S., additional, FERREIRA, J. D. F., additional, OLIVEIRA, L. V., additional, NOGUEIRA, L. U., additional, FIGUEIRÊDO, M. T. A., additional, GOMES, R. M. U., additional, SOUSA, S. M., additional, and GUEDES, S. P., additional

Published
2019
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25. Fatigue behaviour of a self-healing dental composite.

Author

Ning, K., Yang, F., Bronkhorst, E.M., Ruben, J.L., Nogueira, L., Haugen, H., Loomans, B.A.C., Leeuwenburgh, S.C.G., Ning, K., Yang, F., Bronkhorst, E.M., Ruben, J.L., Nogueira, L., Haugen, H., Loomans, B.A.C., and Leeuwenburgh, S.C.G.

Abstract

Contains fulltext : 296918.pdf (Publisher’s version ) (Open Access), OBJECTIVE: Novel self-healing resin-based composites containing microcapsules have been developed to improve the mechanical performance of dental restorations. However, the long-term fatigue behaviour of these self-healing composites has still been hardly investigated. Therefore, this manuscript studied the fatigue behaviour of self-healing composites containing microcapsules by subjecting the specimens to traditional staircase tests and ageing in a custom-designed chewing simulator (Rub&Roll) to simulate oral ageing physiologically relevant conditions. METHODS: To prepare self-healing composite, poly(urea-formaldehyde) microcapsules containing acrylic self-healing liquids were synthesized. Subsequently, these microcapsules (10 wt%) and initiator (benzoyl peroxide, BPO, 2 wt%) were incorporated into a commercial flowable resin-based composite. Microcapsule-free resin-based composites with and without BPO were also prepared as control specimens. A three-point flexural test was used to measure the initial flexural strength (S(initial)). Subsequently, half of the specimens were used for fatigue testing using a common staircase approach to measure the fatigue strengths (FS). In addition, the other specimens were aged in the Rub&Roll machine for four weeks where after the final flexural strength (S(final)) was measured. RESULTS: Compared to S(initial), FS of all tested specimens significantly decreased as measured through staircase testing. After 4 weeks of ageing in the Rub&Roll machine, S(final) was significantly reduced compared to S(initial) for microcapsule-free resin-based composites, but not for the self-healing composites (p = 0.3658). However, the self-healing composites are still in the experimental phase characterized by a low mechanical strength, which still impedes further clinical translation. SIGNIFICANCE: Self-healing composites containing microcapsules exhibit improved fatigue resistance compared to microcapsule-free non-self-healing composites.

Published
2023

27. Investigation of Rhodnius prolixus head anatomy using microtomography

Author

Sena, Gabriela, primary, da Silva, Ademir X., additional, Nogueira, L. P., additional, Colaço, M. V., additional, Mestcher, Brian, additional, Fidalgo, G., additional, Pickler, A., additional, Azambuja, P., additional, Gonzalez, M. S., additional, Mattos, D. P, additional, and Barroso, Regina.Cely., additional

Published
2023
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29. Deliverable 7.2: Full Project Knowledge Integration Report with Results, Procedures and Recommendations

Author

Mangalagiu, D., Biddau, F., Brisudová, L., Cappello, E., Chakraborty, S., Codina, G., Costa, C., Cots, F., Dale, B., Flamos, A., Fosse, J., Frajer, J., Frankowski, J., Frantál, B., Greene, C., Groome, P., Ismail, C., Katiforis, Z., Kleanthis, N., Lilliestam, J., Maier, R., Mandel, A., Martinát, S., Mazurkiewicz, J., Hansen, A., Mey, F., Michas, S., Møller, R., Nogueira, L., Pearce, B., Pujol, D., Sarrica, M., Sokolowski, J., Steininger, K., Steiro, V., Sveinsdóttir, A., Tuerk, A., Tàbara, J., Takama, T., Todor, A., Țăranu, A., Udrea, R., Veland, S., and Virla, L.

Abstract

The Deliverable 7.2 “Full Project Knowledge Integration Report with Results, Procedures and Recommendations” aims to present the operational process of knowledge integration and key project results and recommendations on Social-Ecological Tipping Points (SETPs) to accelerate low-carbon, clean energy transitions in CCIRs.

Published
2023

32. Role of SHP2 (PTPN11) in glycoprotein VI-dependent thrombus formation: Improved platelet responsiveness by the allosteric drug SHP099 in Noonan syndrome patients

Author

Fernández, D.I., Diender, M.G., Hermida-Nogueira, L., Huang, Jingnan, Veiras, S., Henskens, Y.M.C., Loo, M. te, Heemskerk, J.W.M., Kuijpers, M.J.E., and García, Á.

Subjects
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Contains fulltext : 294565.pdf (Publisher’s version ) (Open Access) INTRODUCTION: The protein tyrosine phosphatase SHP2 (PTPN11) is a negative regulator of glycoprotein VI (GPVI)-induced platelet signal under certain conditions. Clinical trials with derivatives of the allosteric drug SHP099, inhibiting SHP2, are ongoing as potential therapy for solid cancers. Gain-of-function mutations of the PTPN11 gene are observed in part of the patients with the Noonan syndrome, associated with a mild bleeding disorder. Assessment of the effects of SHP2 inhibition in platelets from controls and Noonan syndrome patients. MATERIALS AND METHODS: Washed human platelets were incubated with SHP099 and stimulated with collagen-related peptide (CRP) for stirred aggregation and flow cytometric measurements. Whole-blood microfluidics assays using a dosed collagen and tissue factor coating were performed to assess shear-dependent thrombus and fibrin formation. Effects on clot formation were evaluated by thromboelastometry. RESULTS: Pharmacological inhibition of SHP2 did not alter GPVI-dependent platelet aggregation under stirring, but it enhanced integrin αIIbβ3 activation in response to CRP. Using whole-blood microfluidics, SHP099 increased the thrombus buildup on collagen surfaces. In the presence of tissue factor and coagulation, SHP099 increased thrombus size and reduced time to fibrin formation. Blood from PTPN11-mutated Noonan syndrome patients, with low platelet responsiveness, after ex vivo treatment with SHP099 showed a normalized platelet function. In thromboelastometry, SHP2 inhibition tended to increase tissue factor-induced blood clotting profiles with tranexamic acid, preventing fibrinolysis. CONCLUSION: Pharmacological inhibition of SHP2 by the allosteric drug SHP099 enhances GPVI-induced platelet activation under shear conditions with a potential to improve platelet functions of Noonan syndrome patients.

Published
2023

38. Highly elastic and bioactive bone biomimetic scaffolds based on platelet lysate and biomineralized cellulose nanocrystals

Author

Ribeiro, J. P., Domingues, R. M. A., Babo, P. S., Nogueira, L., Reseland, J., Reis, R. L., Gomez-Florit, Manuel, Gomes, Manuela E., and Universidade do Minho

Subjects
Nanoscale biomineralization, cryogels, Science & Technology, Calcium Phosphate, Cellulose nanocrystals, hydroxyapatite, Platelet lysate, Non-collagenous proteins
Abstract

Bone is a vascularized organic-inorganic composite tissue that shows a heavily-mineralized extracellular matrix (ECM) on the nanoscale. Herein, the nucleation of calcium phosphates during the biomineralization process was mimicked using negatively-charged cellulose nanocrystals (CNCs). These mineralized-CNCs were combined with platelet lysate to produce nanocomposite scaffolds through cryogelation to mimic bone ECM protein-mineral composite nature and take advantage of the bioactivity steaming from platelet-derived biomolecules. The nanocomposite scaffolds showed high microporosity (94â 95%), high elasticity (recover from 75% strain cycles), injectability, and modulated platelet-derived growth factors sequestration and release. Furthermore, they increased alkaline phosphatase activity (up to 10-fold) and up-regulated the expression of bone-related markers (up to 2-fold), without osteogenic supplementation, demonstrating their osteoinductive properties. Also, the scaffolds promoted the chemotaxis of endothelial cells and enhanced the expression of endothelial markers, showing proangiogenic potential. These results suggest that the mineralized nanocomposite scaffolds can enhance bone regeneration by simultaneously promoting osteogenesis and angiogenesis., We acknowledge the financial support from Research Council of Norway for project no. 287953 and from Portuguese Foundation for Science and Technology (FCT) for CEECIND/01375/2017 to MGF and 2020.03410.CEECIND to RMAD. We also acknowledge Dr. Margarida Miranda (3B's Research Group, University of Minho) for the TGA analysis.

Published
2022

40. A reply to “Relevant factors in the eutrophication of the Uruguay River and the Río Negro”

Author

Alcántara, I., Somma, A., Chalar, G., Fabre, A., Segura, A., Achkar, M., Arocena, R., Aubriot, L., Baladán, C., Barrios, M., Bonilla, S., Burwood, M., Calliari, D.L., Calvo, C., Capurro, L., Carballo, C., Céspedes-Payret, C., Conde, D., Corrales, N., Cremella, B., Crisci, C., Cuevas, J., De Giacomi, S., De León, L., Delbene, L., Díaz, I., Fleitas, V., González-Bergonzoni, I., González-Madina, L., González-Piana, M., Goyenola, G., Gutiérrez, O., Haakonsson, S., Iglesias, C., Kruk, C., Lacerot, G., Langone, J., Lepillanca, F., Lucas, C., Martigani, F., Martínez de la Escalera, G., Meerhoff, M., Nogueira, L., Olano, H., Pacheco, J.P., Panario, D., Piccini, C., Quintans, F., Teixeira de Mello, F., Terradas, L., Tesitore, G., Vidal, L., and García-Rodríguez, F.

Published
2022
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41. Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Author

Delaby, C, Teunissen, CE, Blennow, K, Alcolea, D, Arisi, I, Amar, EB, Beaume, A, Bedel, A, Bellomo, G, Bigot-Corbel, E, Bjerke, M, Blanc-Quintin, M-C, Boada, M, Bousiges, O, Chapman, MD, DeMarco, ML, D'Onofrio, M, Dumurgier, J, Dufour-Rainfray, D, Engelborghs, S, Esselmann, H, Fogli, A, Gabelle, A, Galloni, E, Gondolf, C, Grandhomme, F, Grau-Rivera, O, Hart, M, Ikeuchi, T, Jeromin, A, Kasuga, K, Keshavan, A, Khalil, M, Koertvelyessy, P, Kulczynska-Przybik, A, Laplanche, J-L, Lewczuk, P, Li, Q-X, Lleo, A, Malaplate, C, Marquie, M, Masters, CL, Mroczko, B, Nogueira, L, Orellana, A, Otto, M, Oudart, J-B, Paquet, C, Paoletti, FP, Parnetti, L, Perret-Liaudet, A, Peoc'h, K, Poesen, K, Puig-Pijoan, A, Quadrio, I, Quillard-Muraine, M, Rucheton, B, Schraen, S, Schott, JM, Shaw, LM, Suarez-Calvet, M, Tsolaki, M, Tumani, H, Udeh-Momoh, CT, Vaudran, L, Verbeek, MM, Verde, F, Vermunt, L, Vogelgsang, J, Wiltfang, J, Zetterberg, H, Lehmann, S, Delaby, C, Teunissen, CE, Blennow, K, Alcolea, D, Arisi, I, Amar, EB, Beaume, A, Bedel, A, Bellomo, G, Bigot-Corbel, E, Bjerke, M, Blanc-Quintin, M-C, Boada, M, Bousiges, O, Chapman, MD, DeMarco, ML, D'Onofrio, M, Dumurgier, J, Dufour-Rainfray, D, Engelborghs, S, Esselmann, H, Fogli, A, Gabelle, A, Galloni, E, Gondolf, C, Grandhomme, F, Grau-Rivera, O, Hart, M, Ikeuchi, T, Jeromin, A, Kasuga, K, Keshavan, A, Khalil, M, Koertvelyessy, P, Kulczynska-Przybik, A, Laplanche, J-L, Lewczuk, P, Li, Q-X, Lleo, A, Malaplate, C, Marquie, M, Masters, CL, Mroczko, B, Nogueira, L, Orellana, A, Otto, M, Oudart, J-B, Paquet, C, Paoletti, FP, Parnetti, L, Perret-Liaudet, A, Peoc'h, K, Poesen, K, Puig-Pijoan, A, Quadrio, I, Quillard-Muraine, M, Rucheton, B, Schraen, S, Schott, JM, Shaw, LM, Suarez-Calvet, M, Tsolaki, M, Tumani, H, Udeh-Momoh, CT, Vaudran, L, Verbeek, MM, Verde, F, Vermunt, L, Vogelgsang, J, Wiltfang, J, Zetterberg, H, and Lehmann, S

Abstract

INTRODUCTION: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. METHODS: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. RESULTS: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. DISCUSSION: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.

Published
2022

42. Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Author

Delaby, C., Teunissen, C.E., Blennow, K., Alcolea, D., Arisi, I., Amar, E.B., Beaume, A., Bedel, A., Bellomo, G., Bigot-Corbel, E., Bjerke, M., Blanc-Quintin, M.C., Boada, M., Bousiges, O., Chapman, M.D., DeMarco, M.L., D'Onofrio, M., Dumurgier, J., Dufour-Rainfray, D., Engelborghs, S., Esselmann, H., Fogli, A., Gabelle, A., Galloni, E., Gondolf, C., Grandhomme, F., Grau-Rivera, O., Hart, M., Ikeuchi, T., Jeromin, A., Kasuga, K., Keshavan, A., Khalil, M., Körtvelyessy, P., Kulczynska-Przybik, A., Laplanche, J.L., Lewczuk, P., Li, Q.X., Lleó, A., Malaplate, C., Marquié, M., Masters, C.L., Mroczko, B., Nogueira, L., Orellana, A., Otto, M., Oudart, J.B., Paquet, C., Paoletti, F.P., Parnetti, L., Perret-Liaudet, A., Peoc'h, K., Poesen, K., Puig-Pijoan, A., Quadrio, I., Quillard-Muraine, M., Rucheton, B., Schraen, S., Schott, J.M., Shaw, L.M., Suárez-Calvet, M., Tsolaki, M., Tumani, H., Udeh-Momoh, C.T., Vaudran, L., Verbeek, M.M., Verde, F., Vermunt, L., Vogelgsang, J., Wiltfang, J., Zetterberg, H., Lehmann, S., Delaby, C., Teunissen, C.E., Blennow, K., Alcolea, D., Arisi, I., Amar, E.B., Beaume, A., Bedel, A., Bellomo, G., Bigot-Corbel, E., Bjerke, M., Blanc-Quintin, M.C., Boada, M., Bousiges, O., Chapman, M.D., DeMarco, M.L., D'Onofrio, M., Dumurgier, J., Dufour-Rainfray, D., Engelborghs, S., Esselmann, H., Fogli, A., Gabelle, A., Galloni, E., Gondolf, C., Grandhomme, F., Grau-Rivera, O., Hart, M., Ikeuchi, T., Jeromin, A., Kasuga, K., Keshavan, A., Khalil, M., Körtvelyessy, P., Kulczynska-Przybik, A., Laplanche, J.L., Lewczuk, P., Li, Q.X., Lleó, A., Malaplate, C., Marquié, M., Masters, C.L., Mroczko, B., Nogueira, L., Orellana, A., Otto, M., Oudart, J.B., Paquet, C., Paoletti, F.P., Parnetti, L., Perret-Liaudet, A., Peoc'h, K., Poesen, K., Puig-Pijoan, A., Quadrio, I., Quillard-Muraine, M., Rucheton, B., Schraen, S., Schott, J.M., Shaw, L.M., Suárez-Calvet, M., Tsolaki, M., Tumani, H., Udeh-Momoh, C.T., Vaudran, L., Verbeek, M.M., Verde, F., Vermunt, L., Vogelgsang, J., Wiltfang, J., Zetterberg, H., and Lehmann, S.

Abstract

Item does not contain fulltext, INTRODUCTION: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. METHODS: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. RESULTS: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. DISCUSSION: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.

Published
2022

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