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7. Supplementary Figure 4 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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8. Supplementary Figure 1 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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9. Supplementary Figure Legend from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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10. Supplementary Table 1 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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11. Supplementary Figure 3 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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12. Data from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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13. Supplementary Figure 5 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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14. Supplementary Table 2 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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15. Supplementary Figure 2 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

Author

Miyajima, Naoto, primary, Tsutsumi, Shinji, primary, Sourbier, Carole, primary, Beebe, Kristin, primary, Mollapour, Mehdi, primary, Rivas, Candy, primary, Yoshida, Soichiro, primary, Trepel, Jane B., primary, Huang, Ying, primary, Tatokoro, Manabu, primary, Shinohara, Nobuo, primary, Nonomura, Katsuya, primary, and Neckers, Len, primary

Published
2023
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38. Prolonged treatment with three-weekly docetaxel plus daily prednisolone for metastatic castration-resistant prostate cancer: a multicenter, phase II, open-label, non-comparative, extension study in Japan

Author

Nishimura, Kazuo, Nonomura, Norio, Hashine, Katsuyoshi, Kanayama, Hiro-omi, Ozono, Seiichiro, Miura, Takeshi, Miki, Tsuneharu, Kakehi, Yoshiyuki, Arai, Yoichi, Ogawa, Osamu, Fujita, Ryuji, Nonomura, Katsuya, Mizokami, Atsushi, Hoshi, Senji, and Akaza, Hideyuki

Published
2013
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49. The association of prenatal exposure to perfluorinated chemicals with glucocorticoid and androgenic hormones in cord blood samples: the Hokkaido study

Author

Goudarzi, Houman, Araki, Atsuko, Itoh, Sachiko, Sasaki, Seiko, Miyashita, Chihiro, Mitsui, Takahiko, Nakazawa, Hiroyuki, Nonomura, Katsuya, and Kishi, Reiko

Subjects
Organofluorine compounds -- Health aspects, Maternal-fetal exchange -- Health aspects, Corticosteroids -- Properties, Fetal blood -- Testing, Androgens -- Properties, Environmental issues, Health
Abstract

BACKGROUND: Perfluorinated chemicals (PFCs) disrupt cholesterol homeostasis. All steroid hormones are derived from cholesterol, and steroid hormones such as glucocorticoids and androgenic hormones mediate several vital physiologic functions. However, the in utero effects of PFCs exposure on the homeostasis of these steroid hormones are not well understood in humans. OBJECTIVES: We examined the relationship between prenatal exposure to perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) and cord blood levels of glucocorticoid and androgenic hormones. METHODS: We conducted a hospital-based birth cohort study between July 2002 and October 2005 in Sapporo, Japan (n = 514). In total, 185 mother-infant pairs were included in the present study. Prenatal PFOS and PFOA levels in maternal serum samples were measured using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Cord blood levels of glucocorticoid (cortisol and cortisone) and androgenic hormones [dehydroepiandrosterone (DHEA) and androstenedione] were also measured in the same way. RESULTS: We found a dose-response relationship of prenatal PFOS, but not PFOA, exposure with glucocorticoid levels after adjusting for potential confounders. Cortisol and cortisone concentrations were -23.98-ng/mL (95% CI: -0.47.12, -11.99; p for trend = 0.006) and -63.21-ng/mL (95% CI: -132.56, -26.72; p for trend < 0.001) lower, respectively, in infants with prenatal PFOS exposure in the fourth quartile compared with those in the first quartile. The highest quartile of prenatal PFOS exposure was positively associated with a 1.33-ng/mL higher DHEA level compared with the lowest quartile (95% CI: 0.17, 1.82; p for trend = 0.017), whereas PFOA showed a negative association with DHEA levels (quartile 4 vs. quartile 1: -1.23 ng/mL, 95% CI: -1.72, -0.25; p for trend = 0.004). We observed no significant association between PFCs and androstenedione levels. CONCLUSIONS: Our results indicate that prenatal exposure to PFCs is significantly associated with glucocorticoid and DHEA levels in cord blood. http://dx.doi.org/10.1289/EHP142, Introduction Perfluorinated chemicals (PFCs) are human-made chemicals that have been widely used in different types of industry for the past 60 years. They are ubiquitous and widely detected in the [...]

Published
2017
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