1. Effect of nonpharmacological interventions on nutrition status, complications and quality of life in head and neck cancer patients undergoing radiotherapy: A systematic review and meta‐analysis.
- Author
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Jin, Xiaolei, Fan, Yuying, Guo, Conghui, Yang, Jianrong, Zeng, Ying‐chun, and Zhang, Jun‐e
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HEAD & neck cancer treatment , *PSYCHOTHERAPY , *WEIGHT loss , *STOMATITIS , *MEDICAL information storage & retrieval systems , *STATISTICAL models , *THERAPEUTICS , *BODY mass index , *MALNUTRITION , *COMPUTER software , *RESEARCH funding , *HEAD & neck cancer , *EXERCISE therapy , *CANCER patients , *META-analysis , *RELATIVE medical risk , *DESCRIPTIVE statistics , *SYSTEMATIC reviews , *LASER therapy , *MEDLINE , *NUTRITIONAL status , *QUALITY of life , *MEDICAL databases , *DEGLUTITION , *ONLINE information services , *DATA analysis software , *CONFIDENCE intervals , *DIET therapy , *GASTROINTESTINAL diseases , *SENSITIVITY & specificity (Statistics) , *PUBLICATION bias , *PATIENT aftercare , *EVALUATION , *DISEASE risk factors , *DISEASE complications - Abstract
Purpose: To evaluate the effect of nonpharmacological therapies on nutrition status, complications and quality of life in head and neck cancer patients and to provide a basis for clinical practice. Methods: This systematic review was reported in accordance with the Preferred Reporting Items for Systematic Review and Meta‐analysis statement. Ten databases were systematically searched for all available articles from construction to November 2023. Two researchers independently conducted literature screening, data extraction and quality evaluation. Cochrane Review Manager 5.3 was used for meta‐analysis. Results: Finally, 27 RCT studies including 2814 patients with head and neck cancer were included. Five categories of interventions were used: nutritional support, exercise, swallowing function training, psychological intervention and low‐level laser therapy. Nonpharmacological interventions can improve body weight loss in patients with HNC at the end of treatment (MD: 1.66 kg; 95% CI: 0.80 to 2.51), and subgroup analysis showed that nutritional support, psychological intervention and low‐level laser therapy were effective. Nonpharmacological interventions can also ameliorate decreases in BMI (MD: 0.71; 95% CI: 0.16 to 1.26) and reduce the incidence of malnutrition (RR: 0.76; 95% CI: 0.67 to 0.86), oral mucositis (RR: 0.54; 95% CI: 0.37 to 0.80) and gastrointestinal complications (RR: 0.61; 95% CI: 0.38 to 0.96) during radiotherapy; however, no significant differences were found in other complications and quality of life. Conclusion: Nonpharmacological interventions can improve the nutrition status of patients with head and neck cancer and reduce the incidence of severe oral mucositis and gastrointestinal complications during radiotherapy but have no significant impact on quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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