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Abstract The COVID-19 pandemic has been a life-altering experience. It compelled individuals to alter their attitudes and habits and adopt measures to prevent the risks of infection. This research discusses factors that determine adherence to these measures, with the aim of enhancing compliance in future pandemics. A descriptive cross-sectional study was conducted using snowball non-random sampling through an online Qualtrics survey targeting Bahraini residents, aged 18 and older. The sample included 1,008 participants, and data were analyzed using SPSS, and presented in tables and graphs. The majority of the participants were Bahraini females with a bachelor’s degree, between the ages of 20–29 (43.2%). Awareness of COVID-19 transmission was high, with 87.7%. The adherence rates for preventive measures were high: mask usage at 98.8%, hygiene practices at 93.7%, and social distancing at 92.2%. Older adults aged 50 + showed the highest consistency in compliance (p = 0.001). Individuals with chronic diseases were more likely to adhere to mask use (p

Background Thyroid disease is known to be one of the most common endocrine diseases globally and has serious health implications if left untreated. Objective This study aimed to gain a better understanding of common thyroid diseases and to explore the associated risk factors in the Kingdom of Bahrain. Methods A case-control study was carried out after obtaining all thyroid stimulating hormone (TSH) results done in a primary healthcare setting from January 1, 2022 to December 31, 2022 from the Health Information Department. In total, 500 participants were randomly selected from each group: the abnormal thyroid test group (cases) and the normal thyroid test group (controls). Participants were interviewed using a structured list of associated risk factors with the following sections: sociodemographic characteristics, comorbidities, family history of thyroid disease, BMI, previous radiation therapy, and certain medications. Results The prevalence of abnormal thyroid tests was found to be 11%. Cases were categorized into four groups: hyperthyroidism (26.4%), hypothyroidism (64.6%), hyperthyroidism (4.5%), and subclinical hypothyroidism 13 (4.5%). The results showed significant differences between case and control in the following risk factors: female sex, increasing age, BMI, dyslipidemia, family history of thyroid disease, and previous radiation therapy (P =

Background: In recent years, Big Data has invaded many technical sectors, enabling extraordinary advances, notably in robotics. Large amounts of data from many areas may improve robotic system functionality and adaptability. Objective: This article examines Big Data's effects on robotic learning, decision-making, and adaptability to help explain how it advances robotic capabilities and provide a thorough review of integrated data-driven robotic systems. Methods: A thorough evaluation and synthesis of the literature was undertaken to examine the integration and implementation of Big Data in robotics. Case studies, and theoretical frameworks on Big Data analytics and robotics were sought from databases and academic publications. Results: Big Data analytics in robots improves learning in predictive analytics and machine learning algorithms, improving decision-making. Industrial robots and autonomous vehicles boost operational efficiency and flexibility by improving data processing, anomaly detection, and real-time decision-making. Conclusion: Technology such as Big Data and robotics makes robots more adaptive and decision-making. Integration improves robotic capabilities and allows for innovative applications across domains, supporting data-driven robotic ability and improvement decisions. The findings propose using Big Data analytics to improve robotics and study future applications, contributing to the conversation on technological convergences and societal implications.

Abstract Introduction Data on child functioning and disability are important for public policy development which aimed at reducing child disability prevalence and strengthening the provision of appropriate and timely health care services. This study reports the prevalence of functional difficulty in Malaysian children aged 2–17 years and its associated sociodemographic factors and epilepsy. Methods Data on children aged 2–17 years (n = 4576) were generated from the National Health and Morbidity Survey (NHMS) 2019, a population-based cross-sectional survey. Functional difficulty in children was assessed using the United Nations Children’s Fund (UNICEF)/Washington Group on Disability Statistics (WG) Child Functioning Module (CFM). The questionnaires were administered to the parents or guardians of the children via face-to-face interviews. Functional difficulty, defined as having difficulty in at least one domain, was examined for its prevalence and associations with sociodemographic variables and the epilepsy variable in children using descriptive analysis and multiple logistic regression. Results The overall prevalence of functional difficulty among children aged 2–17 years was 4.7%. Multiple logistic regression analysis revealed that older children, children from households whose heads of household had a lower education level and children who have epilepsy were significantly more likely to experience functional difficulty (p

Abstract The atmosphere’s fine articulate Matter (PM2.5) poses various health-related risks. Even though multiple efforts have been made to lower the emissions of these substances, the mortality rate is continuously increasing, requiring immediate inclination of the scientific community towards the design and development of advanced predictive models. Conventional statistical approaches have become dormant due to their limitations in capturing the innate relationships between the pollutants, particularly for predicting PM2.5 concentrations. In contrast, machine and deep learning techniques have shown great potential for forecasting air quality, providing more accuracy than its predecessor techniques. The present study investigates the utilization of hybrid approaches by integrating machine learning models with deep learning models to improve the prediction capabilities of PM2.5 concentration. It uses datasets from the World Air Quality Index (WAQI) and the State of Global Air (SOGA) to analyze the performance of the models on both the daily and annual data, respectively. This ensures the model’s effectiveness on a diversified dataset. The present study implements Random Forest (RF), Polynomial Regression (PR), XGBoost, and Extra Tree Regressor (ETR) coupled with Fully Connected Neural Network (FCNN), Long Short-Term Memory (LSTM), and Bi-directional LSTM (Bi-LSTM) for obtaining optimized results. Finally, after a thorough investigation, the hybrid PR model coupled with FCNN (PR-FCNN) is found to be the best model with improved R-squared (R2) values, portraying its potential for predicting PM2.5 concentration accurately. Based on the experimentation, the preset study recommends implementing hybrid approaches, offering better predictive accuracy in forecasting air pollutants, especially PM2.5.

Purpose – Studies showed that a proactive delivery system employing innovative artificial intelligence (AI) in urban services might perform better. This has become an important national policy for many countries. Thus, this study aims to explore the influence of AI in urban services in Malaysia. Design/methodology/approach – Official documents such as Structure Plan and Government Transformation Programme Policy Document covering various levels of cities in Malaysia, articles related to urban studies mostly written by researchers regarding urban growth in Malaysia and the Urban Development Bulletin from the Federal Department of Town and Country Planning from 1957 to date were reviewed and analysed. Findings – The findings show that the influence of AI in urban services has long existed and been carefully planned by local authorities since colonial times. The development of global digital technology influences the upgrading of AI in urban services in Malaysia. Also, the success of AI in these municipal services is influenced by the rate of information technology literacy among the urban population. These developments have led to the definition of a conceptual city. Research limitations/implications – This paper's findings and conclusion were based on reviewed literature but did not compromise the strength of this paper. Thus, as part of the implications for future research, mixed-methods research design has been suggested. Practical implications – As part of the implications, this article intends to promote AI in urban services in Malaysia and other developing countries with similar urban services challenges. Originality/value – This paper encourages AI applications in urban services because it enhances service delivery performance. This intends to key stakeholders to promote AI via policies across Malaysia's urban services as part of the study implications.

Abstract Background Necrotic enteritis (NE) is an economically important disease of broiler chickens caused by Clostridium perfringens (CP). The pathogenesis, or disease process, of NE is still not clear. This study aimed to identify the alterations of metabolites and metabolic pathways associated with subclinical or clinical NE in CP infected birds and to investigate the possible variations in the metabolic profile of birds infected with different isolates of CP. Methodology Using a well-established NE model, the protein content of feed was changed abruptly before exposing birds to CP isolates with different toxin genes combinations (cpa, cpb2, netB, tpeL; cpa, cpb2, netB; or cpa, cpb2). Metabolomics analysis of jejunal contents was performed by a targeted, fully quantitative LC-MS/MS based assay. Results This study detected statistically significant differential expression of 34 metabolites including organic acids, amino acids, fatty acids, and biogenic amines, including elevation of butyric acid at onset of NE in broiler chickens. Subsequent analysis of broilers infected with CP isolates with different toxin gene combinations confirmed an elevation of butyric acid consistently among 21 differentially expressed metabolites including organic acids, amino acids, and biogenic amines, underscoring its potential role during the development of NE. Furthermore, protein-metabolite network analysis revealed significant alterations in butyric acid and arginine-proline metabolisms. Conclusion This study indicates a significant metabolic difference between CP-infected and non-infected broiler chickens. Among all the metabolites, butyric acid increased significantly in CP-infected birds compared to non-infected healthy broilers. Logistic regression analysis revealed a positive association between butyric acid (coefficient: 1.23, P

Background Preterm infants are at risk of developing nutritional deficiencies, which is further compounded by the fact that providing them with adequate nutrition is often challenging. Enteral feeding (EF) practices vary across neonatal units and can be impacted by the setting and geographical region. There is also a lack of evidence on best practices. Objective To investigate EF practices and related nutrition factors, patterns, and outcomes in preterm infants in Saudi Arabia by examining studies published in this area. Methods A search was conducted for articles on EF practices among preterm infants in Saudi Arabia that were published between January 2010 and May 2024. Searches were carried out across five electronic databases and through searching inward and backward citation and reference lists of relevant papers. Studies that described or assessed EF practices used in preterm infants from any region of Saudi Arabia and were published in English or Arabic were included. Results The database and manual search resulted in 1905 articles. After removing duplicates and applying the inclusion/exclusion criteria, 14 publications were included: 12 were observational studies, 1 was a conference abstract (with retrospective analysis), and 1 was a commentary. Of these, 7 studies were conducted in the Central Province, 6 in the Western Province, and 1 in the Eastern Province. More than half of the publications (8 of 14) were published between 2021 and 2023. The studies included were categorized to three themes based on their aim: studies describing practices on mother–infant bond to encourage breastfeeding, assessing nutritional status and EF, and assessing EF as a risk factor for developing prematurity complications. Conclusion While research activity on EF practices in Saudi Arabia has increased very recently, yet there is a paucity of studies, particularly experimental studies that focus on both short- and long-term health outcomes.

Zinc oxide (ZnO), iron oxide (Fe3O4) NPs, and ZnO/Fe3O4 nanocomposites (NCs) were synthesized using Nigella sativa (NS) seed extracts. These nanomaterials (NMs) were characterized by multiple analytical techniques like UV-visible spectrophotometers, FTIR spectroscopy, SEM, and XRD spectroscopy. The UV-visible spectrum showed 364 nm, 330 nm, and 331nm for ZnO NPs, Fe3O4 NPs, and ZnO/Fe3O4 NCs, respectively. Moreover, it was confirmed when the samples were run through FTIR techniques, and it was observed that the availability of bioactive functional groups was involved in the decline of bulk compounds to NPs. XRD showed their average nanoparticle size based on applying the formula of full width at half maximum (FWHM) for ZnO NPs, Fe3O4 NPs, and ZnO/Fe3O4 NCs at 29.52 nm, 22.08 nm, and 12.82 nm, respectively. In this study, the reduction of Methylene Blue (MB) dye was done by NPs and NCs, and their catalytic activities were investigated by a UV-visible spectrophotometer. MB dye showed the maximum absorption peak at 664 nm, and the reaction of MB was reduced using synthesized products with an accompanying color change reaction from blue to colorless within 60 min at 84%, 86%, and 99.5% degradation for ZnO NPs, Fe3O4 NPs, and ZnO/Fe3O4 NCs with rate constants of 0.00035, 0.00065, and 0.0015 Lmol-1S-1. The 2nd order rate constant was observed in this study. The agar disc diffusion method was used to investigate the potential antibacterial activity of synthesized NPs and NCs. This study is best suited for Gram-positive bacteria. NS seed extract-based synthesis of NCs could be an excellent catalyst and biological application for environmental pollution.

Abstract Background Cardiovascular disease (CVD) is the leading cause of premature mortality worldwide. Despite existing research on CVD risk factors, the study of premature CVD mortality in Malaysia remains limited. This study employs survival analysis to model modifiable risk factors associated with premature CVD mortality among Malaysian adults. Method We utilised data from Malaysia’s National Health and Morbidity Survey (NHMS) conducted in 2006, 2011, and 2015, linked with mortality records. The cohort comprised individuals aged 18 to 70 during the NHMS interview. Follow-up extended to 2021, focusing on CVD-related premature mortality between ages 30 and 70. We employed six survival models: a semi-parametric Cox proportional hazard (PH) and five parametric survival models, which were Exponential, Weibull, Gompertz, log-normal and log-logistic distributions using R software. The age standardized incidence rate (ASIR) of premature CVD mortality was calculated per 1000 person-years. Results Among 63,722 participants, 886 (1.4%) experienced premature CVD mortality, with an ASIR of 1.80 per 1000 person-years. The best-fit models (based on AIC value) were the stratified Cox model by age (semi-parametric) and the log-normal accelerated failure time (AFT) model (parametric). Males had higher risk (Hazard Ratio, HR = 2.68) and experienced 49% shorter survival time (Event Time Ratio, ETR = 0.51) compared to females. Compared to Chinese ethnicity, Indians, Malays, and other Bumiputera had higher HR and lower survival times. Rural residents and those with lower education also faced increased HRs and reduced survival times. Diabetes (diagnosed: HR = 3.26, ETR = 0.37; undiagnosed: HR = 1.63, ETR = 0.63), hypertension (diagnosed: HR = 1.84, ETR = 0.53; undiagnosed: HR = 1.46, ETR = 0.68), and undiagnosed hypercholesterolemia (HR = 1.31, ETR = 0.80) increased risk and decreased survival times. Additionally, current smoking and abdominal obesity elevated risk (HR = 1.38, 1.60) and shortened survival (ETR = 0.81, 0.71). Conclusion The semi-parametric and parametric survival models both highlight the considerable impact of socioeconomic status and modifiable risk factors on premature CVD mortality, underscoring the imperative for targeted interventions to effectively mitigate these effects.

This study aims to investigate the impact of organizational culture (i.e., rational, hierarchical, and group) on healthcare supply chain resilience (SCR) in Jordan. This paper further examines the moderating role of technology integration on the relationship between organizational culture and healthcare SCR. Cross-sectional research was conducted, and participants were recruited from different hospitals in Jordan. An electronic survey was employed to collect the responses from 304 participants, including senior professionals designated as doctors, nurses, ray technicians, physical therapists, procurement officers, pharmacists, and lab technicians with more than three years of work experience. There was no statistically significant influence of rational culture on healthcare SCR (p-value = 0.156) and an adverse impact of hierarchical culture on healthcare SCR (p-value = 0.030). Group culture had a statistically significant impact on healthcare SCR (p-value = 0.007). Technology integration had an influential moderating influence on the association between rational culture and healthcare SCR (p-value = 0.042) and the association between hierarchical culture and healthcare SCR (p-value = 0.0129). However, technology integration had no moderating influence on the association between group culture and healthcare SCR (p-value = 0.331). The analysis revealed that group culture has an influential impact on healthcare SCR, while hierarchical culture has a negative impact on healthcare SCR. Moreover, technological integration was observed to improve the beneficial influence of rational culture and the negative effects of hierarchical culture on healthcare SCR. However, the technology integration was not observed to moderate the relationship between group culture and healthcare SCR. Acknowledgment The author acknowledges all the associated personnel who, in any reference, contributed to the completion of this study.

Abstract This study explores the effectiveness of image restoration strategies in pandemic crisis communication at the highest levels of administration. By integrating corpus-assisted discourse analysis with Image Repair Theory, it aims to uncover the prevailing strategies adopted by Chinese and American leaders to restore or enhance a positive national image in the post-COVID era. Lancsbox 6.0 was utilized to extract excerpts and analyze linguistic devices from a self-built corpus of 144 political speeches delivered by top leaders in China and the United States. The results reveal that Chinese leaders, through the use of shared image restoration strategies such as bolstering and transcendence, shape a positive national image of a responsible country. In contrast, American leaders construct a confident and ambitious national image, projecting a leading geopolitical role in the world. These strategies have distinct features that contribute to the image restoration process. Apart from contributing significantly to the comparative research on Chinese and American pandemic-related political speeches, the research findings carry implications for the practice and promotion of national ideologies. The study also highlights the diverse ways in which credible and accurate crisis messages are employed, providing valuable insights for handling pandemics or other crises in the foreseeable or distant future.

Background:Binding immunoglobulin protein (BiP) is a protein marker associated with endoplasmic reticulum (E.R.) stress and is upregulated by metabolic alterations at the tissue level. There is growing proof that changes in the microbiota’s makeup that cause infections may have a significant impact on the development of associated diseases such as autoimmune diseases by E.R. stress-inducing and a change in cell surface components. Objective:To investigate the role of urinary tract infections (UTIs) in inducing an increase in E.R. stress represented and the innate immune response to this stress. Materials and Methods:A total of 160 male and female children, whose ages ranged between 5 and 10 years participated in this study. Cultivation urine on UTI ChromoSelect Agar used to identify patients with UTI. The levels of BiP and IL-1β concentration were measured using ELISA assay. Lymphocyte and granulocyte cell count and ratio were measured by Complete Blood Count. Results:The major findings of the study were (1) The serum levels of BiP were significantly higher in patients with UTI compared to controls. (2) Upon bacterial stimulation, happened higher increase of IL-1β concentration. (3) The lymphocyte count and ratio were significantly higher but granulocyte ratio was significantly lower in the UTI patients. (4) The most frequent bacteria isolated were Escherichia coli (31.7%), followed by Proteus mirabilis (22.1%), Klebsiella (21.2%), Staphylococcus aureus (12.7%), and Enterococcus faecalis (12.3%). Conclusions:BiP plasma concentrations are increased in UTI patients that suggest the virulence factors of uropathogenic bacteria may be stimulated by epithelial cell stress which leads to activation of the immune system. BiP could be a useful marker to predict the risk of bacterial infections.

Background:A programed death ligand L1 is the particular PD-1 ligand that is primarily found in lymphoid, epithelial, and myeloid cells. In order to activate the PD-1/PD-L1 pathway, which suppresses the production of cytokines and controls immune function, PD-1 must bind to PD-L1. Objectives:Estimating the concentration of PDL_1 in serum and breast tissue of patients with breast tumors. Materials and Methods:Case–control study included 100 women (17–60 years old) undergoing breast surgery at Babylon Province’s Al-Hilla Teaching Hospital and Al-Fayhaa Al Ahly Hospital provided blood and breast tissue samples. Hospital histology lab performed histological confirmation of breast diseases, including benign and malignant tumors. Twenty blood samples were taken as controls from women and men who appeared to be in good health. The enzyme-linked immunosorbent assay was used to determine PDL_1 in both patient and control serum and in the cell supernatant from the patient’s breast tissues. Results:The mean level of PDL_1 in serum of patient was 549.37 ng/L while control was 594.22 ng/L with found significant differences where P value was 0.05. While tissue of patients was 464.97 ng/L. The results appeared concentrations of PDL-L1 were significantly higher in serum compared with tissues at P ≥ 0.05. The results found no significantly differences in concentrations of PDL_1 among types of diseases in sera of patients except in fat necrosis patients. Perhaps as a result of our small sample size, the difference in PD-L1 expression between the various subtypes was not statistically significant. Conclusion:This study found concentration of PDL-1 decreased with primary breast diseases and it might be diagnostic marker.

Concerns regarding man‐made organic chemicals pervading our ecosystem and having adverse and detrimental effects upon organisms, including man, have now been studied for several decades. Since the 1970s, some environmental pollutants were identified as having endocrine disrupting affects. These endocrine disrupting chemicals (EDC) were initially shown to have estrogenic or anti‐estrogenic properties and some were also shown to bind to a variety of hormone receptors. However, since the 1990s it has also been identified that many of these EDC additionally, have the ability of causing abnormal alterations in Ca2+ signalling pathways (also commonly involved in hormone signalling), leading to exaggerated elevations in cytosolic [Ca2+] levels, that is known to cause activation of a number of cell death pathways. The major emphasis of this review is to present a personal perspective of the evidence for some types of EDC, specifically alkylphenols and brominated flame retardants (BFRs), causing direct effects on Ca2+ transporters (mainly the SERCA Ca2+ ATPases), culminating in acute cytotoxicity and cell death. Evidence is also presented to indicate that this Ca2+ATPase inhibition, which leads to abnormally elevated cytosolic [Ca2+], as well as a decreased luminal ER [Ca2+], which triggers the ER stress response, are both involved in acute cytotoxicity.

Background: Staphylococcus spp. are widely distributed in nature and can cause nosocomial, skin infections, and foodborne illness, and it may lead to severe financial losses in birds by causing systemic infection in numerous organs. Aim: This study was conducted to determine the prevalence of Staphylococcus spp. in humans and birds in Baghdad city. Methods: Seventy-six oral cavity swabs were collected, including 41 from birds and 35 from breeders. All samples were examined by bacteriological methods and identified by using the VITEK technique, the samples were then further studied to test the ability of biofilm formation, and MDR factors and MAR index were tested with the use of seven antibiotics. Results: Among the 76 oral swabs, 37 samples were positive (48.68%) for Staphylococcus spp.: 7 human samples (20%) and 30 bird samples (73.17%). In humans, S. lentus was the most prevalent (42.85%) followed by S. aureus (28.57%), S. hominis and S. sciuri were at (14.29%) to each. In birds, S. pseudintermedius, S. gallinarum, S. lentus, S. haemolyticus, Staphylococcus spp, S. sciuri and S. xylosus were detected in 36.67%, 16.67%, 10%, 10%, 13.33%, 3.33% and 3.33% respectively. Staphylococcus isolates from the human samples demonstrated that only S. lentus was resistant 33.33% to ME, OX, and SXT. Furthermore, one of them was MDR and high MAR index value. The antimicrobial pattern of Staphylococcus spp. isolated from birds was as follows: S. pseudintermedius isolates demonstrated 100% resistance to CN, CIP, SXT, and MDR (100%) and high MAR indices value; S. xylosus was resistant 100% against ME, CN, SXT and Do and it was MDR with high MAR index;S. lentus was resistant 25% against ME, OX, C, and SXT, whereas, S. gallinarum was resistant 33.33% against ME and OX. The results demonstrated that biofilm formation of the Staphylococcus spp. isolated from human samples were weak biofilm formers: S. lentus, S. hominis, and S. aureus, while other S. aureus (50%) was moderate. In birds, the majority of the isolates had non biofilm-producing capabilities, while 80% of S. lentus and 100% of S. xylosus showed moderate biofilm formation. Conclusion: Healthcare problem was observed in this study due to high MDR and MAR index among Staphylococcus spp. isolated from pet birds to their owners and vice versa. [Open Vet J 2024; 14(9.000): 2215-2223]

Background: Theileriosis infection is a tick-borne disease that leads to global animal morbidity, mortality and economic losses. Aim: This study aimed to examine Theileriosis infection by traditional and molecular methods Methods: A total of 100 blood samples of local breed cows were examined by Giemsa smearing under a microscope, amplified-PCR in region 18SrRNA PCR at 600bp, and DNA sequencing analysis the genetic relationships. Results: The clinical signs showed that an elevated fever [40.3-41.5°C], an asymmetrical extension of superficially prescapular lymph nodes, lacrimation, icteric mucus membranes eyes, ecchymotic haemorrhages on sclera, dullness, lethargy, salivation, and ticks presence. Giemsa-stained blood smear and conventional PCR were revealed 24% and 73% for infection respectively. Phylogenetic tree was constructed with DNA sequencing analysis of accession number: OQ779946.1, OQ779947.1, OQ779949.1, OQ779952.1, OQ779953.1 and OQ779953.1, belonging to T. annulata; acc. nos.: OQ779950.1, OQ779951.1 belong to T. parva; acc. nos.: OQ779948.1, OQ779960.1 belongs to Theileria species; acc. no.: OQ779955.1, OQ779957.1, OQ779958.1 belong to T. sergenti; and OQ779956.1, OQ779959.1 belong to T. orientalis. Nucleotide substitutions of transversion and transitions occurred in 11 types containing gaps and missing are A>T; A>C; A>G; C>A; C>G; C>T; G>A; G>C; G>T; T>A; T>C for 254 positions in final dataset. Conclusion: This study showed theileriosis infection is highly endemic and represent a first investigation into use of molecular phylogeny to classify Theileria in Al-Fallujah City, West Region of Iraq. [Open Vet J 2024; 14(9.000): 2261-2268]

Abstract Methamphetamine is a synthetic psychostimulant that is showing a rising trend of usage among adolescents and youths. Its harmful side effects and high risk of developing addiction is a public health problem. Recognizing the knowledge, attitudes, and practices (KAP) on methamphetamine is critical in the planning of an intervention strategy. Currently there is a lack of KAP questionnaires on methamphetamine. The study aims to develop and validate a KAP questionnaire on methamphetamine-use for use among Malaysian adolescents. Following an extensive literature review, face and content validity were carried out among healthcare workers, the public, students, and local subject matter experts. A pilot study was conducted amongst 50 students to assess the test-retest reliability. The questionnaire was then distributed to two groups of 269 and 331 individuals for the Exploratory (EFA) and Confirmatory Factor Analysis (CFA), respectively. The internal reliability was also assessed among these groups. The content validation consisting of Item Content Validity Index (I-CVI, ranging from 0.875 to 1.00), and Scale Content Validity Index (S-CVI/Ave = 0.941) both showed good validation scores. Test-retest reliability showcased an Intraclass Correlation Coefficient (ICC) of > 0.7, indicating its reliability. The model was constructed via the EFA resulting in four constructs, and the model’s goodness of fit was confirmed with CFA. An internal reliability was calculated with Cronbach’s Alpha and showed acceptable reliability (α-values > 0.6) for all constructs. The KAP questionnaire of methamphetamine use is a valid and reliable tool that can be used among Malaysian adolescents. The model arising from this study, can also be used as a guide for future intervention models for adolescent methamphetamine-use disorder.

Global Navigation Satellite Systems (GNSS) has become an essential component in modern times for positioning, navigation, and timing. A fast-growing economic region in Malaysia required a GNSS-based augmentation positioning and navigation service. To improve navigation solution, several augmentation techniques exist, such as a differential Global Positioning System (DGPS) assisted by reference station, or augmentation service provided by commercial communication satellite. The DGPS correction is applied through a real-time communication medium and can be received at the user side by several communication methods including internet-based, and this method is favourable for land and near-coast areas. This case study aims to investigate the reliability of internet-based DGPS and SBAS along the Peninsular Malaysia. A test was conducted and data were collected over 15 hours at a rate of 1 Hz from the available GNSS satellite using a geodetic-grade receiver mounted on a moving vehicle. The obtained results showed that DGPS and SBAS perform better than the navigation solution with an accuracy of 1.536 m and 0.955 m respectively, compared to the navigation solution with an accuracy of 3.159 m. The limitations of both augmentation techniques were also analysed and discussed in this study.

Long COVID comprises persistent symptoms that extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long COVID and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries, where high endorsement of these theories has been reported. This study aimed to explore the association between endorsing COVID-19 conspiracy theories and the prevalence of self-reported long COVID symptoms among adults in Jordan and Kuwait in addition to other Arab countries. The study employed a cross-sectional design using Computer-Assisted Web Interviewing (CAWI), conducted in Arabic. Recruitment utilized convenience-based snowball sampling via social media and the survey was distributed in July 2024. Long COVID manifestations were assessed across ten recognized symptoms, and belief in conspiracy theories was measured using a five-point Likert scale across five items. The final study sample comprised 755 respondents, the majority of whom self-reported a history of confirmed COVID-19 diagnosis at least once (n = 493, 65.2%). The results indicated a neutral average attitude towards COVID-19 conspiracy theories (mean score = 15.18 ± 4.64 out of 30.00). Participants with high COVID-19 conspiracy theories scores were more likely to report high (aOR = 6.85, p < 0.001) or middle long COVID symptoms (aOR = 2.82, p = 0.008) compared to those with lower scores. Additional predictors of higher long COVID reporting included female sex, lower household income, frequent COVID-19 infections, and hospitalizations. The study results revealed a significant correlation between the endorsement of COVID-19 conspiracy theories and a higher frequency and magnitude of long COVID symptom reporting. The findings also highlighted the influence of sociodemographic factors and COVID-19 infection history on long COVID reporting, which suggests that public health strategies should address these factors to mitigate long COVID challenges effectively.

Abstract Background The rapid evolution of nanotechnology has fundamentally transformed both medical and dental fields. By harnessing nanomaterials, researchers have unlocked the ability to replicate natural tissue structures and properties, significantly enhancing integration processes. Notably, nanostructures have emerged as pivotal elements in oral medicine, particularly in combating dental caries and enhancing outcomes in dental implants and maxillofacial surgeries. Main body of the abstract Nanostructures play multifaceted roles in oral health, promoting osseointegration and expediting healing processes in dental procedures. The impact of these materials extends to improving the adhesive strength and overall properties of dental composites. This review critically evaluates the influence of nanointerfaces on the longevity of dental restorations, exploring innovative nanotechnological interventions aimed at augmenting restoration durability. Furthermore, recent strides in nanodentistry are discussed, highlighting breakthroughs in oral health diagnostics, preventative strategies, and treatment modalities essential for achieving and sustaining optimal oral health. Short conclusion Incorporating nanotechnology into dental practice presents exciting prospects for advancing oral healthcare. From enhancing restoration durability to revolutionizing diagnostics and treatments, nanotechnology offers transformative solutions that hold significant promise for the future of oral health management.

This study aims to explore the interaction effects of the audit committee (AC), the internal audit function (IAF), as well as the external auditors (EA) toward earnings management between government-linked companies (GLCs) in Malaysia. This study used regression analysis on 340 firm-year-based observations with Malaysian GLCs available on the Bursa Malaysia main board during the 2009 – 2018. This study found that the interaction between the AC and the IAF is significantly and negatively correlated with EM. However, the AC's interaction with the EA shows an insignificant relationship in reducing EM. Additionally, the interaction between EA and the IAF negatively affects EM. It is one of the first papers to explore the complementary impact of external and internal corporate governance functionality or mechanisms on EM.

With the intensifying challenge of global warming driven largely by anthropogenic activities, effective greenhouse gas capture techniques are critical. This paper focuses on the role of deep eutectic solvents (DES) as promising agents for such capture at the source. We review the key DES-based methods for greenhouse gas capture, drawing conclusions from a thorough analysis of the existing literature. In particular, we examine the effect of DES structure on gas solubilities and explore the mechanism of gas solubility in DES through molecular simulation. We present a synthesis of state-of-the-art results in this area, assessing the potential of DES as an alternative to current industrial gas capture methods. Furthermore, we propose future research directions for the design of novel DES tailored to more specific applications.

Environmental monitoring of pesticide residues has become increasingly crucial for ensuring food safety and environmental sustainability. Current demands are not met by traditional analytical tools, but the integration of smartphones, due to their small size, high accessibility, fast processing speed, and powerful imaging capacity, holds significant potential for on-site detection of pesticide residues. This review provides a comprehensive overview of the latest developments in the application of molecularly imprinted polymer (MIP) sensors equipped with smartphones for the detection of pesticide residues in environmental samples, covering the period from 2018 to 2024. The review encompasses recent advancements in MIP synthesis, sensor fabrication, and the incorporation of principles for improved signal precision with the integration of smartphones based on sensing signals (optical and electrochemical signals). Additionally, the diverse range of environmental samples were explored, including water, soil, and crops, where MIP sensors have demonstrated their efficacy in detecting pesticides. The potential for real-time monitoring and the challenges associated with deploying these sensors at lab scale are discussed. Overall, this review highlights the transformative impact of MIP sensors with smartphone-based detection in the field of pesticide residue analysis, paving the way for enhanced environmental monitoring practices.

It is widely known that the impact of atmospheric humidity on tribological phenomena is significant, particularly in the context of dry sliding. Previous reviews have comprehensively addressed various cases within this domain and this article aims to complement these reviews with recent findings. The review covers a wide spectrum of humidity levels, ranging from trace amounts of water in the order of a few vol ppb to the relative humidity levels experienced in daily life. It delineates the forms of adsorbed water on solid surfaces within each humidity range and explores the potential physical lubrication mechanism of the adsorbed water and its effects on tribological phenomena. In the past, explanations for this influence have tended to be qualitative, primarily viewed from the perspective of chemical reactions. This discussion seeks to broaden the understanding by considering the influences from a physical lubrication perspective. Concluding the review, recent research findings are presented, shedding light on instances where trace amounts of water present in gases such as hydrogen exert an influence on tribological phenomena.

Encapsulation plays a vital role in the food industry, known for its multifunction constituents’ preservation, covering undesirable food components (taste, color, flavor), nutritional and functional components incorporation, and under controlled conditions (time and rate) release of encapsulation ingredients. Milk proteins are highly demanding encapsulating material and are investigated at large scale to design encapsulating devices. Polyphenols, flavorings, fatty acids, minerals, and hydrophobic vitamins are within encapsulating bioactives. Milk protein is widely used in the microencapsulation (ME) of probiotics and in comparison to other biomaterials offers more benefits. Milk protein includes whey protein and casein and several techniques are developed to make use of them in the ME of multiple probiotic strains (Bifidobacterium, Lactobacillus). This review will cover all the possible aspects of dairy proteins and their properties that enabled them to be used as encapsulating material. This review will also discuss the range of hydrophobic and hydrophilic components delivered from milk protein and their utilization in the formation of encapsulating agents. Overall, this study aimed to explore the emerging role of encapsulation in the food industry, characterize milk proteins as effective encapsulation agents, investigate their synergism with nondairy encapsulating materials, and evaluate various encapsulation techniques.

In this study, tempeh was developed using a probiotic culture of Lactobacillus rhamnosus adjunct culture. Purposely, soybean seeds were soaked overnight at room temperature and then boiled at 100°C for 10 to 15 min. The hot beans were then spread out in a thin layer and allowed to cool to room temperature. The Lactobacillus rhamnosus culture was added to the soybeans, which were then tightly packed in perforated plastic bags and incubated at 30°C for 24 h to produce fresh tempeh. The tempeh was then analyzed for its physical, chemical, microbial, and sensory characteristics, and the data obtained was statistically analyzed. The results of the physical and chemical analysis showed that the probiotic tempeh had a slight increase in pH, ash, and protein content, while there was a significant decrease in acidity, moisture, and fat content during storage. The microbial analysis revealed that both the total plate count and probiotic count increased over time, with treatment T4, which contained a high amount of culture, exhibiting the maximum plate count and probiotic count. The sensory evaluation showed that both the treatment and storage duration significantly impacted the aroma, color, taste, and overall acceptability of the tempeh, with all sensory attributes decreasing over time. The sensory panelists rated treatment T4 the highest for overall acceptance. In conclusion, the study suggests that probiotic soybean tempeh could be a beneficial carrier for producing a product with good physicochemical properties, acceptability, high probiotic viability, and storage durability.

Abstract Background Diabetes is a major public health problem in Qatar and is associated with an increased risk of depression. However, no study has been conducted in Qatar on the relationship between dietary patterns and depression symptoms in adults. The aim of this study was to assess the association between dietary patterns and depression symptoms among adults with or without diabetes in Qatar. Methods A total of 1000 participants from the Qatar Biobank (QBB) were included in this cross-sectional study. Food intake was assessed using a computer-administered food frequency questionnaire (FFQ), and dietary patterns were identified using factor analysis. Depression symptoms were evaluated using the Patient Health Questionnaire-9 (PHQ-9). Results Depression symptoms were present in 13.5% of the sample. Two dietary patterns were identified: “unhealthy” (high consumption of fast food, biryani, mixed dish (chicken/meat/fish), croissant) and “prudent” (high consumption of fresh fruit, salads/raw vegetables, canned/dried fruit, and dates). After adjusting for sociodemographic, lifestyle factors (smoking and physical activity), diabetes and medication use for diabetes and hypertension, a high intake of “unhealthy” pattern was associated with an increased prevalence of depressive symptoms in individuals with diabetes (prevalence ratio, PR = 1.41; 95% CI = 1.28, 1.56; p-value

Abstract Background A logbook system is essential to ensure standardized competency in medical education. This survey will provide the first overview of our current logbook and can serve as an initial proposal for improvement to a more relevant and valuable tool to assess our postgraduate training programme. Methods This survey was conducted among all Universiti Kebangsaan Malaysia (UKM) anaesthetic trainees. The data for this survey was collected by using Google Forms. A link to the form was distributed to all UKM anaesthetic trainees. The survey questionnaire consisted of five sections, demographic data, strengths and weaknesses of logbook content, evaluation of logbook usage experience, perception of the feedback received regarding the logbook performance, and potential improvements that can be made. Results 107 anaesthetic trainees participated in this study. All of the sections in the logbook were deemed relevant by more than 60% of the trainees except for the on-call section which was seen as relevant only by 37.4% of them. 53.3% agreed that the logbook is useful for learning during the course. However, only 43.9% of them perceived that the logbook was easy and convenient to use. Only 59 respondents received feedback regarding their logbook performance. The analysis of open-ended answers highlights the necessity of transitioning to a fully digitalized logbook system for easy accessibility. It also reveals the need to re-evaluate specific logbook contents and incorporate additional teaching and learning tools to enhance the overall training process. Moreover, the findings emphasize the importance of effectively implementing feedback mechanisms within the logbook system to optimize student learning. Conclusion Serving as a foundational step towards developing a more efficient and structured educational tool, this research provides valuable insights for future advancements in medical education, particularly in anaesthesiology.

This study aims to explore the impact of coronavirus pandemic-related variables and non-pharmaceutical interventions on fluctuations in the Malaysian stock market during the period from January 7, 2020, to March 31, 2021. By employing GARCH-M (1,1) family models (GARCH-M, EGARCH-M, and PGARCH-M), the study seeks to understand the intricate dynamics of market volatility amidst the pandemic and associated interventions. The findings suggest that while past market volatility and conditional variance continue to influence current market fluctuations, their effects have diminished over time during the study period. Additionally, the EGARCH-M (1,1) model reveals a leverage effect, indicating increased market volatility following negative news compared to positive news. Interestingly, the EGARCH-M (1,1) model emerges as the optimal choice for accurately capturing data dynamics. Conversely, the PGARCH-M (1,1) model does not exhibit a statistically significant leverage effect. These insights contribute to a better understanding of market behavior during crises, informing future research and risk management strategies. AcknowledgmentThe authors are grateful to the Middle East University, Amman, Jordan, for the full financial support granted to this research paper.

Abstract Background Substance use disorders are a widely recognized problem among hepatitis C-infected patients; moreover, substance abuse by intravenous injection is a common mode of transmission of the hepatitis C virus worldwide. The frequency of substance use disorders and their relation to hepatitis C infection are still unknown in Iraq. This cross-sectional study, conducted among a sample of hepatitis C- infected patients attending the Gastrointestinal Tract Center in Baghdad Medical City, aimed to examine the prevalence of substance use disorders, the sociodemographic characteristics of the abusers, and the relation between intravenous drug abuse and hepatitis C virus infection. All participants were subjected to an Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) questionnaire and a data form to determine sociodemographic characteristics and hepatitis C virus-related risk factors. Results In a total of 300 hepatitis C virus-infected patients, the prevalence of substance use disorders was 53.6%. Among these patients, 43.6% abused nicotine, 6% abused licit drugs, and 4% abused alcohol. No one reported illicit drug abuse. Intravenous drug abuse was rare, and there was no relationship found between intravenous drug abuse and hepatitis C infection. Cupping (23%) and blood transfusion (20.3%) were both significantly associated with hepatitis C transmission in this study (p > 0.001). Conclusion This study revealed a high prevalence (53.6%) of substance abuse in this sample of hepatitis C-infected patients, with nicotine being the most commonly abused substance. However, there was no relationship between hepatitis C infection and intravenous drug abuse. Common risk factors that might contribute to hepatitis C transmission among this population include cupping and blood transfusion.

Abstract Background Equitable geographical distribution of health resources, such as hospital beds, is fundamental in ensuring public accessibility to healthcare services. This study examines the distribution of hospital beds across Saudi Arabia's 20 health regions. Methods A secondary data analysis was conducted using the 2022 Saudi Ministry of Health Statistical Yearbook. The study focused on calculating the hospital beds-per-1,000-people ratio across Saudi Arabia's 20 health regions. The analysis involved comparing regional bed distributions using the Gini index and Lorenz curve to assess the distribution of hospital beds. Results The national average beds-per-1,000-people ratio was 2.43, serving a population of approximately 32.2 million. The calculated mean Gini index for bed distribution was 0.15, which indicates a relatively equitable distribution. Further analysis revealed some regional disparities, with health regions like Makkah and Jeddah displaying critically low bed-to-population ratios. In contrast, others like Al-Jouf and the Northern region reported higher ratios. The study also identified the need for an additional 17,062 beds to meet international standards of 2.9 beds per 1,000 people. Conclusions The findings revealed a national average beds-per-1,000-people ratio of 2.43, with some regional disparities. The study highlights the critical need for targeted healthcare planning and policy interventions to address the uneven distribution of hospital beds across Saudi Arabia. Trial registration Not applicable.

Abstract Targeting brain insulin resistance (BIR) has become an attractive alternative to traditional therapeutic treatments for Alzheimer’s disease (AD). Incretin receptor agonists (IRAs), targeting either or both of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, have proven to reverse BIR and improve cognition in mouse models of AD. We previously showed that many, but not all, IRAs can cross the blood-brain barrier (BBB) after intravenous (IV) delivery. Here we determined if widespread brain uptake of IRAs could be achieved by circumventing the BBB using intranasal (IN) delivery, which has the added advantage of minimizing adverse gastrointestinal effects of systemically delivered IRAs. Of the 5 radiolabeled IRAs tested (exenatide, dulaglutide, semaglutide, DA4-JC, and DA5-CH) in CD-1 mice, exenatide, dulaglutide, and DA4-JC were successfully distributed throughout the brain following IN delivery. We observed significant sex differences in uptake for DA4-JC. Dulaglutide and DA4-JC exhibited high uptake by the hippocampus and multiple neocortical areas. We further tested and found the presence of AD-associated Aβ pathology minimally affected uptake of dulaglutide and DA4-JC. Of the 5 tested IRAs, dulaglutide and DA4-JC are best capable of accessing brain regions most vulnerable in AD (neocortex and hippocampus) after IN administration. Future studies will need to be performed to determine if IN IRA delivery can reduce BIR in AD or animal models of that disorder.

Law enforcement against exhibitionists is crucial in maintaining public order and morality. This study examines law enforcement against exhibitionists based on criminal law and Islamic criminal law. The research method used is normative legal research with a statute and conceptual approach. The statute approach is employed to review existing laws and regulations. In contrast, the conceptual approach explores the principles of Islamic criminal law related to law enforcement against exhibitionism. The results of this study show that in the context of general criminal law, the Indonesian Penal Code (KUHP) regulates articles that can be applied to exhibitionists. Criminal sanctions stipulated in Articles 281 and 282 of the Penal Code include imprisonment and fines for those who distribute, create, or store obscene images, including those involving exhibitionism. Article 335 of the Penal Code also regulates indecent acts in public, which can include exhibitionism. According to Islamic criminal law, the form of punishment for exhibitionist behavior is jarimah ta'zir. Among the Syafi'iyah and Hanabillah scholars, it is argued that the maximum punishment is ten lashes. Meanwhile, according to the Malikiyyah scholars, the punishment of lashes may exceed this limit as long as it serves a beneficial purpose. This study concludes that law enforcement against exhibitionism requires integrating general and Islamic criminal law to create a balanced legal framework that aligns with societal values. Additionally, the importance of public awareness of the social impact of exhibitionism and participation in law enforcement is emphasized

Abstract Genetic heterogeneity in ovarian cancer indicates the need for personalised treatment approaches. Currently, very few G-protein coupled receptors (GPCRs) have been investigated for active targeting with nanomedicines such as antibody-conjugated drugs and drug-loaded nanoparticles, highlighting a neglected potential to develop personalised treatment. To address the genetic heterogeneity of ovarian cancer, a future personalised approach could include the identification of unique GPCRs expressed in cancer biopsies, matched with personalised GPCR-targeted nanomedicines, for the delivery of lethal drugs to tumour tissue before, during and after surgery. Here we report on the systematic analysis of public ribonucleic acid-sequencing (RNA-seq) gene expression data, which led to prioritisation of 13 GPCRs as candidates with frequent overexpression in ovarian cancer tissues. Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used to confirm frequent gene expression for the selected GPCRs. However, the expression levels showed high variability within our selection of samples, therefore, supporting and emphasising the need for the future development of case-to-case personalised targeting approaches.

Abstract Dombi operations based on the Dombi t-norm (TN) and t-conorm (TCN) have the advantage in terms of operational parameter flexibility in dealing with varying degrees of uncertainty and aggregation requirements. Meanwhile, Heronian mean (HM) operator is an effective technique for capturing the interrelationship between any number of inputs. Bipolar neutrosophic set (BNS) offers the ability to represent both positive and negative information as well as indeterminate information. It is beneficial in cases where there is uncertainty or insufficient information. However, the existing Dombi operator under BNS do not take into account the interrelationship between input arguments. To overcome this limitation, this study incorporates Dombi operator into HM and propose the bipolar neutrosophic Dombi Heronian mean aggregation operator. This paper introduces two type of aggregation operators namely bipolar neutrosophic Dombi-based generalized weighted Heronian mean (BND-GWHM), and bipolar neutrosophic Dombi-based improved generalized weighted Heronian mean (BND-IGWHM). The proposed operators are integrated into MCDM procedure. The influence of different parameter values on decision-making results is discussed. Finally, a comparison analysis with existing methods is also provided.

Abstract Many studies have investigated the coronary risk factors (CRFs) among premature coronary artery disease (PCAD) patients. However, reports on the proportion and CRFs of PCAD according to different age cut-offs for PCAD is globally under-reported. This study aimed to determine the proportion of PCAD patients and analyse the significant CRFs according to different age cut-offs among percutaneous coronary intervention (PCI)-treated patients. Patients who underwent PCI between 2007 and 2018 in two cardiology centres were included (n = 29,241) and were grouped into four age cut-off groups that defines PCAD: (A) Males/females:

Abstract Background Interprofessional education (IPE) is essential to foster collaboration among healthcare professionals for holistic patient care. However, Malaysian dental education remains discipline-centric, hindering multidisciplinary learning approaches. Hence, this study aimed to explore Malaysian undergraduate dental students’ perceptions of IPE. Methods The present cross-sectional study employed convenience sampling to survey undergraduate dental students from four Malaysian institutions using a modified questionnaire with 20 close-ended and 2 open-ended questions. The questionnaire covered three domains (effectiveness, preference, importance) to assess students’ perceptions using a five-point Likert scale. Psychometric validation was performed to assure validity and reliability of the modified questionnaire. Quantitative analysis (descriptive and inferential statistics), and qualitative analysis (content analysis) were subsequently performed. Results 397 students responded, and positive perceptions were generally noted with mean scores ranging from 4.13 to 4.35 across all domains. Questions 2 and 3, assessing the improvement in understanding the roles and responsibilities, and communication among healthcare professionals, received the highest mean scores. Meanwhile, Question 15 concerning the incorporation of IPE into educational goals received the lowest mean score. Regression analysis identified gender and clinical phase as significant factors, with females and preclinical students exhibiting more favourable perceptions. Motivators for IPE included a keen interest in diverse perspectives and recognising the importance of teamwork, while barriers encompassed tightly packed schedules, lack of understanding about IPE, misconceptions regarding dental education, and students’ nervousness and fear of participation. Conclusion This study produced a valid and reliable instrument to measure undergraduate dental students’ perceptions towards IPE. Strategic planning, such as overcoming logistical challenges, improving awareness, and creating a supportive learning environment are crucial for successful IPE integration into existing curricula, especially in resource-constrained developing countries like Malaysia.

Abstract Newborn screening (NBS) programs are believed to play an important role in the decrease of infant mortality rates in many countries. This is achieved through offering early detection and treatment of many genetic as well as metabolic disorders prior to the onset of symptoms. Our paper examines NBS across seven diverse nations: Saudi Arabia, the United States, Japan, Singapore, Canada, Australia, and the United Kingdom. This paper discusses the diseases screened for by each country, latest additions, as well as future recommendations, when applicable. Employing a comparative approach, we conducted a comprehensive review of the most recent published literature on NBS programs in each country and subsequently examined their latest implemented NBS guidelines as outlined on their respective official government health sector websites. We then reviewed the economic feasibility of each of these programs and factors that affect implementation and overall benefit. While all six countries employ well-developed programs, variations are observed. Those variations are mainly attributed to disparities in access, resource scarcity, financial availability, as well as ethical and cultural considerations. From a local perspective, we recommend conducting further population-based studies to assess the epidemiological data in relation to the disease burden on the country’s economy. Moreover, we recommend updating national and international guidelines to contain a more comprehensive approach on policies, operation, and sustainability to deliver a service through the lens of value-based healthcare.

The era of disruption significantly engineered a classic testing system into an adaptive testing system where each test taker takes a unique test. However, the carrying capacity of the adaptive testing system engineering is experiencing obstacles in terms of the method of presenting the test questions. The study aims to introduce the low-high adaptive tracking method with the item response theory approach, where the difficulty level of the questions is adapted to the test takers' abilities. The number of test questions in the question bank is 400 questions. Data analysis used the Bilog-MG program. The range of the difficulty level of the questions and the ability level of the test takers was determined [-3.3]. The initialization of the ability of each test taker is set flexibly. The test taker's response uses the pattern of all wrong, all true, and normal responses. The research results show that the low-high method with the IRT approach matches the pattern of the method of giving adaptive test questions. The low-high method requires about 17 test questions to find the ability of the test takers. Another characteristic of the low-high method is that if the responses of the test takers' three to five questions are all correct, then the calculation of divergent abilities is positive, and if the responses of the test takers' three to five questions are all wrong, then the calculation of convergent abilities is negative. Teachers can use the low-high method to design and assemble adaptive tests in schools electronically and manually.

This study examines the utilization of process optimization as a viable strategy for addressing the issue of global warming through the conversion of carbon dioxide into methanol. In the realm of computational chemistry, the response surface methodology approach has evolved as an alternative for optimizing the reaction parameters through the utilization of statistical models. In the present study, promoted copper/zinc oxide/alumina catalyst was used for carbon dioxide conversion to methanol. The primary objective of the study was to enhance the overall methanol yield by optimizing the various factors in the methanol synthesis. This was accomplished by employing a combination of response surface methodology and one factor at a time techniques. The creation of statistical models was used to optimize the essential factors, and subsequently, one factor at a time. This helps in determining the optimum pressure, temperature, and hydrogen/carbon dioxide molar ratio. Impregnation technique was employed for the synthesis of promoted copper/zinc oxide/alumina catalyst. The analysis of variance results suggested the reduced quadratic model for carbon dioxide conversion, methanol selectivity and methanol yield as responses. The optimum process operating conditions were found to be the hydrogen/carbon dioxide ratio of 10, temperature of 300°C, pressure of 31 bar and gas hourly space velocity of 2160 mL/g.h, in which 28.6% carbon dioxide conversion, 59.2% methanol selectivity and 16.4% methanol yield were achieved. The catalytic performance was then investigated for high pressure range of 40 – 80 bar with other conditions were fixed at optimal value. The carbon dioxide conversion and methanol selectivity were found to increase with increasing pressure. The highest catalytic performance was achieved at 80 bar with carbon dioxide conversion of 68.35%, methanol selectivity of 93%, and methanol yield of 63.57%.

This study includes the stratigraphic development of the Late Jurassic succession in eight boreholes namely, Si-1, Sal-1, Sa-1, Dn-1, Ki-1, R-172, WQ-15, and KSK -1, within the Mesopotamian Zone. The present study is concluded that the current area represents as part of the northern Arabian plate that was subjected to severe structural deformations prior to the beginning of the Late Jurassic sedimentation, which led to the formation of a vast depression (half graben) that formed a starved basin. This graben was created because of rift-related tectonism called extensional tectonic phase in the latest Middle Jurassic period, which led to the accumulation of high organic matter and formed the source rock (Naokelekan Formation) in the middle part of the graben during their highest and settings. Then this phase was followed by the occupation of the sedimentations (evaporates) in the center of the studied basin during the lowest conditions of the (Gotnia Formation) in the southern Iraq, Kuwait, and southwest Iran. During the highest and system tract after transgressive stage of the Sargelu Formation, the horst surrounding the graben, represents carbonate platforms, which consist of coral structures deposition that follow by Ooids deposits (non-skeletal) and then covered by evaporates sabkha type sediment (cap rock), this succession of sediments called the Najmah Formation. The lowstands stage conditions which are underlying by the sequence boundary type-I, which overlie the Najmah Formation and has been penetrated by Si-1, Sal-1, Sa-1 and Dn-1 wells in the southwestern of Iraq, the sequence boundary considered to be the time equivalent of the Gotnia Formation. The system of the north Arabian plate (Iraq, Kuwait) characterized by an extensional tectonic setting that formed a graben surrounded by shallow water carbonate (horst), while a relatively stable tectonic system predominant at the south-west of the Arabian plate due to its proximity to the Arabian shield, which led to the formation of a wide and flat carbonate platform (Najmah Formation) were covered by Sabkha evaporates.

In this study, multi-structured coatings of biocompatible and antibacterial materials on a 316L stainless steel (SS) implant have been electrophoretically deposited for orthopedic applications. Two layers of composite coatings have been deposited; the first layer of composite coating biopolymer layer consists of (chitosan with Gelatin) and the second composite coating layer of bio-ceramic comprises Hydroxyapatite with chitosan. The first layer was deposited at (3 g/L concentration of Gelatin, 20 voltage, and 3 min and 0.5 g/L chitosan) parameters, and the second layer was deposited at (6 g/L, 40 voltage, 1 min, and 0.5 g/L chitosan) parameters. In this study, the stability of the suspension was evaluated using the Zeta potential test, which manifested good stability. The adhesion strength between the composite coatings' first layer and the 316L stainless steel substrate, as well as between the coating layers themselves, was determined using the Tape test, and the removal area for the first layer was 8.06% while for the second layer was 6.01%. The wettability test elucidated for the 316L stainless steel and first coating layer and the second coating layer, the second composite coating layer became super hydrophilic, and a very high wettability was exhibited with multilayer coating. Scanning electron microscopy showed that the surface's topology revealed a homogenous and defect-free composite coating. The result of the antibacterial efficiency of the 316L SS substrate improved as the number of coating composite layers increased, and the resistance to corrosion of 316L SS enhanced as the number of coating composite layers increased.

Abstract Multiple Sclerosis (MS) is a complex autoimmune disorder that significantly impacts the central nervous system, leading to a range of complications. While intracranial haemorrhage (ICH) is a rare but highly morbid complication, more common CNS complications include progressive multifocal leukoencephalopathy (PML) and other CNS infections. This severe form of stroke, known for its high morbidity and mortality rates, presents a critical challenge in the management of MS. The use of disease-modifying drugs (DMDs) in treating MS introduces a nuanced aspect to patient care, with certain medications like Dimethyl Fumarate and Fingolimod showing potential in reducing the risk of ICH, while others such as Alemtuzumab and Mitoxantrone are associated with an increased risk. Understanding the intricate relationship between these DMDs, the pathophysiological mechanisms of ICH, and the individualised aspects of each patient's condition is paramount. Factors such as genetic predispositions, existing comorbidities, and lifestyle choices play a crucial role in tailoring treatment approaches, emphasising the importance of a personalised, vigilant therapeutic strategy. The necessity for ongoing and detailed research cannot be overstated. It is crucial to explore the long-term effects of DMDs on ICH occurrence and prognosis in MS patients, aiming to refine clinical practices and promote patient-centric, informed therapeutic decisions. This approach ensures that the management of MS is not only comprehensive but also adaptable to the evolving understanding of the disease and its treatments.

Strength enhancement of non-seismic concrete beam–column joints (NSCBCJs) via carbon fiber-reinforced polymer composites (CFRPCs) integration has become a viable strategy. However, the implementation of these NSCBCJs without transverse reinforcement shows poor performance during earthquakes in seismic locations. Thus, strengthening the anti-seismic performance of NSCBCJs to meet the acceptance criteria of ACI 374.1-05 is fundamentally significant. Yet, in addition to limited experimental results, only a few numerical studies based on the finite element model have been performed to determine the anti-seismic behavior of NSCBCJs. Consequently, the stress contribution of CFRPCs to NSCBCJs is not clearly understood. Therefore, we used a finite element model to examine the strength contribution of CFRPCs to NSCBCJs. The performance of the proposed finite element model was validated using the experimental results, demonstrating a good agreement between them. It was shown that the strength of NSCBCJs was improved due to CFRPC incorporation, thereby achieving compliance with the seismic requirements of ACI 374.1-05. In addition, CFRPCs presence could enhance the confinement, reduce the deformation of the NSCBCJs and, thus, decrease their stiffness and strength degradation, while simultaneously improving the energy dissipation.

Bone diseases are a serious health problem such as arthritis and osteoporosis. Their effects on the bones, structures, and tissues affect human life. Therefore, developing novel materials to evolve bone damage therapy is required. Bio-ceramic synthesis witnessed increased interest and attention due to the progression of bio-ceramic as high-quality materials to enhance bone healing, replacement, or regeneration. Among the inorganic materials, bioglasses and ceramics showed promising applications in medicine fields due to their several biological properties; for example, biocompatible, their compositions are similar to those in bones osteoinductive and osteoconductive. Thus, they considered promising materials for scaffold manufacturing to promote bone healing. This review aims to present the recent advancements in various classes of bio-ceramics, including inert-ceramics, bioactive ceramics, and bio-resorbable ceramics, and their wide medical applications in bone regeneration, overhauling skeletomuscular, as well as their mechanical issues.

Abstract Background Curriculum integration is an important educational concept widely implemented by various educational institutions, particularly within the healthcare field. Its significance lies in enhancing the preparation of future healthcare professionals. The assessment of these integrated curricula is imperative to guarantee their effectiveness. Consequently, the aim of this systematic review is to delve into existing literature, with the goal of identifying instruments designed to assess the extent of curriculum integration in health professions’ education. Methods A comprehensive search was conducted to identify peer-reviewed papers and grey literature describing the development, validation, or use of instruments measuring the degree of integration in a curriculum. Eight databases were searched: PubMed, Scopus, Google Scholar, CINAHL Ultimate, Web of Science, Cochrane, ProQuest Central and EMBASE. Grey literature was also included. Titles, abstracts, and full text screening was conducted. Data extraction was done using a data extraction tool developed by our research team. Results The search resulted in the identification of 2094 references. After the removal of duplicates and title and abstract screening, 16 articles were deemed suitable for inclusion in this systematic review. Twenty-two instruments were extracted from these articles. The identified instruments assessed either integration attributes, perceptions about the integrated curriculum characteristics, process and outcomes, or curriculum integration level. Two of the instruments were focused on assessing horizontal integration (Basic Science Curriculum Assessment Instrument and the integration characteristic tool). In addition, one instrument was developed to assess integration within a single session only, while other instruments assessed curriculum integration level. Two of the integration instruments (The Session Integration Tool and Integration Ladder Questionnaire) provided scales for calculating integration levels. Validation of the integration assessment instruments was infrequent, with only 9 of 22 instruments validated for their psychometric properties. Conclusion Our findings reveal the existence of diverse instruments designed to assess the extent of curriculum integration within health professions’ curricula. The majority of identified instruments were focused on participants’ perceptions towards the attributes of the integrated curriculum, and a significant number of these tools lacked validation.

Abstract Treatment intensification is essential to ensure guideline targets are attained in diabetes patients. The failure to intensify treatment when the targets are not achieved is therapeutic inertia. This study aimed to determine the proportions and factors associated with treatment intensification and therapeutic inertia of antihypertensive therapy in type 2 diabetes patients with uncontrolled hypertension in Malaysia. A retrospective cohort analysis was conducted utilising registry data. Diabetes hypertensive patients with uncontrolled baseline systolic or diastolic blood pressure were included. Treatment intensification was the increase in the number of antihypertensive agents from the index treatment. Therapeutic inertia was the absence of treatment intensification when the second blood pressure reading was still uncontrolled. About 6956 patients were followed up over 2.5 ± 1.1 person-years. Treatment intensification was observed in 29.8% of patients, while 38.6% had therapeutic inertia. Chinese, Indian, and ‘others’ ethnic groups, retinopathy, more antihypertensive agents, and higher systolic blood pressure were associated with therapeutic inertia. Underweight, overweight patients and those with dyslipidaemia had lower risks for therapeutic inertia. The results indicate suboptimal quality of care in public health clinics in Malaysia. Further studies are needed to determine the underlying causes to formulate precise interventions to tackle the problem in Malaysia.

Objective: The study purpose was to examine the shear bonding strength of heat cure acrylic resin to thermoplastic resin and three-dimensional printed resin materials. Methods: A total of 30 acrylic specimens were fabricated in this study. Each specimen had a basal and top parts. The basal part was rectangular in shape. We had three different groups: 10 specimens of a basal part made of heat cured polymethylmethacrylate, 10 specimens of a basal part made of thermoplastic, and 10 specimens of three dimensionally printed resin. The top part of which is attached to the basal one was formed into a cylindrical shape made of heat cure poly methyl methacrylate in all three groups. Results: Significant differences were found between the heat cured polymethylmethacrylate and the other two groups (P

BackgroundColorectal cancer (CRC) is the leading cancer among Saudis, and mutations in BRAF, KRAS, and NRAS genes are therapeutically significant due to their association with pathways critical for cell cycle regulation. This study evaluates the prevalence and frequency of somatic mutations in these actionable genes in Saudi CRC patients and assesses their pathogenicity with bioinformatics methods.MethodologyThe study employed the TruSight Tumor 15 next-generation sequencing (NGS) panel on 86 colorectal cancer (CRC) samples to detect somatic mutations in BRAF, KRAS, and NRAS genes. Bioinformatic analyses of NGS sequences included variant annotation with ANNOVAR, pathogenicity prediction, variant reclassification with CancerVar, and extensive structural analysis. Additionally, molecular docking assessed the binding of Encorafenib to wild-type and mutant BRAF proteins, providing insights into the therapeutic relevance of pathogenic variants.ResultsOut of 86 tumor samples, 40 (46.5%) harbored somatic mutations within actionable genes (BRAF: 2.3%, KRAS: 43%, NRAS: 2.3%). Fourteen missense variants were identified (BRAF: n = 1, KRAS: n = 11, NRAS: n = 2). Variants with strong clinical significance included BRAF V600E (2.32%) and KRAS G12D (18.60%). Variants with potential clinical significance included several KRAS and an NRAS mutation, while variants of unknown significance included KRAS E49K and NRAS R102Q. One variant was novel: NRAS R102Q, and two were rare: KRAS E49K and G138E. We further extended the CancerVar prediction capability by adding new pathogenicity prediction tools. Molecular docking demonstrated that Encorafenib inhibits the V600E variant BRAF protein less effectively compared to its wild-type counterpart.ConclusionOverall, this study highlights the importance of comprehensive molecular screening and bioinformatics in understanding the mutational landscape of CRC in the Saudi population, ultimately improving targeted drug treatments.